PB0241

DATABASE

Click here to access PB0241 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0241	A1X283	SH3 and PX domain-containing protein 2B	SH3PXD2B	FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4, SH3 and PX domains 2B	Homo_sapiens	Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).

Domains

Gene Ontology

PF00018 (3_SH3_1) PF00787 (PX) PF07653 (SH3_2)

GO:0005515 (enables) protein binding GO:0010314 (enables) phosphatidylinositol-5-phosphate binding GO:0016176 (enables) superoxide-generating NADPH oxidase activator activity GO:0032266 (enables) phosphatidylinositol-3-phosphate binding GO:0035091 (enables) phosphatidylinositol binding GO:0042169 (enables) SH2 domain binding GO:0080025 (enables) phosphatidylinositol-3,5-bisphosphate binding GO:0001501 (involved in) skeletal system development GO:0001654 (involved in) eye development GO:0006801 (involved in) superoxide metabolic process GO:0007507 (involved in) heart development GO:0022617 (involved in) extracellular matrix disassembly GO:0030154 (involved in) cell differentiation GO:0042554 (involved in) superoxide anion generation GO:0050790 (involved in) regulation of catalytic activity GO:0060348 (involved in) bone development GO:0060612 (involved in) adipose tissue development GO:0071800 (involved in) podosome assembly GO:0072657 (involved in) protein localization to membrane GO:0002102 (located in) podosome GO:0005737 (located in) cytoplasm GO:0042995 (located in) cell projection GO:0070161 (located in) anchoring junction

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|A1X283|SPD2B_HUMAN SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG WIPSNYLRKKP
Selected proteins from model organisms >sp|A1X283|SPD2B_HUMAN SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3 MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFP MEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQ FFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVD IIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL DGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNL PKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDS GLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKSEGELLERE RERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGH KVLAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQ VDICNLRSKLRPAKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLS PKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRG PQCEGHESRAAPTPGRALLVPPKAKPFLSNSLGGQDDTRGKGSLGPWGTGKIGENREKAA AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEG WIPSNYLRKKP >NP_796338.2 SH3 and PX domain-containing protein 2B [Mus musculus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSG EPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPAT FIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKG GKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILP MIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQN LFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPG EGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSP LSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAAS FLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP >XP_017453105.1 SH3 and PX domain-containing protein 2B isoform X1 [Rattus norvegicus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPVEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEVSWRYCSLPRSVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGVVVEVIQ KNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRD GRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG LKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPE AVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKS EEELLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSKFPLRNDMGLECGHKVLAK EVKKPNLRPISRSKAELPEEKVEPNPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRPAKS QEKALLDGESHHAAGGHDTALGRSFLPGEGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPV PVQEATQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGSQREESRAIPASGRALLVPPKAKPFLSNSSVG QDDIRGKGGLGPRIAGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGW WFCRVLSGAPSWEGWIPSNYLRKKP >XP_025010804.2 SH3 and PX domain-containing protein 2B isoform X1 [Gallus gallus] MPRRSIAEVKVLDVQKRRIPNKHYVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQR IIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKK SGFIQRTTSFLQRGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQG WVPATCLEAQDGVQDELSMQPDEVPWRYWSLPRHVGRRRTLGDLYTSGWGQEEKYTVIYPYTARDQDEMN LDKGAVVVVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGEMFSQKLGSGSSAHSCALDLDGISRQQAVTS REKDGRFDNRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTIPDGIS FQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASRPNFLAPLPSEMAQLRLGDAAAESSA TEEATGPCRPLPEAPPNGMDCGMKRAKDWKGKEATESGDLAFTCGYEEISDRDVEEKPSLPPRKESIIKS EGELLERQRPPPKPPGMILPMIPPKQSAAPKDSKKPELKPEKGKLFQLKNEMGLECGHKVSAKEVKKPNL RPIVKPTKPKAEPVEDKTEPITQNPFLKSRPQIKPKPATAPRTDPPPADDKLDICSLRSKLRPAKCPEKP PEQDTAASESSCSTPAVAPEASGRFQERPSVESKALPKSPPGPAVAPAAREPTPQRPVVPPRRPPPPKKT TSPVAGPVPEARASPLPGRPMLVPPKARPFLSAAIQDEAKVKSSVGPKVISKAVERGEGRERTSAPFSNP DVSKEALYVAVADFEGDEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKKP >XP_016809693.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan troglodytes] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQ KNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSE ATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKS EGELLERERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKV LAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRP AKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGSGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKS VPVPLQEAPQQRPVVPPRRPPPPKKTSSSPRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSL GGQDDTRGKGSLGPWGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKN SSGWWFCQVLSGAPSWEGWIPSNYLRKKP >XP_546237.7 SH3 and PX domain-containing protein 2B isoform X1 [Canis lupus familiaris] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GMQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQ KNLEGWWKIRYQGKEGWAPASYLKKSSGEPLPPKPGTGSPAHTGILDLDGLSRQQSSVGRDRELLNNQRD GRFEGRPVPDGDIKQRSPKMRQRPPPRRDMTIPRGLHLPKPPVPPQVEEEYYTIAEFQTTIPDGISFQAG LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVTQLHLGDAAAMENNTGSE AIGPSRPLPDAPHGAMDSGMPWSKDWKGGKEVPRKASSDMSSCAGYEEISSPDLEEKPSLPPRKESIIKS EGELQERERQRMEQLRGSSPKPPGMILPMIPAKHTPPARDGRRSEPKPDKGKLLQLKNEMGLECGHKVLA KEVKKPNLRPISKSKADLPEEKPEGIPQNPFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAK SQEKPLLDGEGSQDVACSRSFLPGEGPGRTQDRTGKQDGLSPKEVPCRAPPKPVKTADPVPKNVPTPLQE ASPQRPVVLPRRPPPPKKTSSSRPLPEVRGPQREASEGKAAPAPGRALLVPPKAKPFLSNSSGGHDDMRG KGGLGPWLVGKIGENREKVAAAPFPSADGSKDSLYVAVANFEGDKDTSSFQEGTVFEVREKSSSGWWFCQ VLSGAPSWEGWIPSNYLKKKP >XP_024837195.1 SH3 and PX domain-containing protein 2B [Bos taurus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSG EPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKG GKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEEELQERQRMEQFRGSSPKPPGMILPMI PAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAVPQNL FLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPG EGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASLQRPVVPPRRPPPPKKTSSSSR PLPEVRGPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKG GLGPRMMGKTGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQS GAPSWEGWIPSNYLRKKP >XP_005170345.1 SH3 and PX domain-containing protein 2B isoform X1 [Danio rerio] MPRRTVLEVTVQDVQKRRNPNKHYVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKDPKRR IIPFLPGKILFRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPSGKKK SGIVERASSFLKRGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKNESGWWFVSTEDAQG WVPATCLEAQDDPDDFSLPAEEEEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQGKEGWA PASYLKKADILSQKMAAGAPVHASTNDLDVACKQQNANKENKENQRDRFSPFSDSKRKVGARQRPPPRRD LTIPRGVNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGLKVEVIEKNSSGWWYIQIEDKEGWAPVTF IDKYKKTSSASRPNFLAPLPGEMEQLKLEDTSSNSTNSEHTWSKPLPDEPSSNSDLSTRSKLREWKPNAA KSSSHFSGPLPPPPSSPTAEEKPALPPRRESINKSLELEDKPKAELSKPLPPKPPVPGVIAPLVTPKAAP LKPDKPPEMKKDDKNKQLFLRNEMGLECGHNISVKEVKKFNLKHVAKQPPTKPKPDLQEDKPESPNPAPF LKPKPVIRPKPAPAAKPEPVAKNELDITNLRSKLRPSKPPELNSSDANQQNDTSSSSPPNNSRTNEEPKC LPKQQNGHGPSETTKPPKEPPQRPSVAPRRPPPPKKSSEPASPTDTRAPQKDLPEAKPAPPPQSRPPPPK TKAFPLPAPKDKEKEEPKPKVPVPPKPLVKPDKPGPPRDKLPPLIKEPSKEELFLAVADFEGDEQTPGFK EGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTKKP >XP_017196747.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Oryctolagus cuniculus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLVPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGGDLASVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSMQSEEVSWRYWSLPRSVGRRRTLGDLNAISWRPEEKYTVIYPYTARDQDEMNLDRGAVVEVIQ KNLEGWWKIRYQGKEGWAPASYLKKSSGEPLPPKLGLSSAAHPGALDLDGVSRQQNAVGREKELLNNQRD GRFEGRPGPEGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG LKVKVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVAQLRLGDTAAMENSPGGE AVGPSRPLPEAPHGAVDLGMPWSKDWKGGKDVLRKASSDMSASAGYEEISDPDLEEKPSLPPRKESIIKS EGELLERERQRLEQLRGSSPKAPGMILPMVPAKHASPARDGRRLEPRPDKSKVFQLKNDMGLECGHKVLA KEVKKPNLRPVPKSKAEVPDEKPEAAPQNPFLKSRPQVRPKPSPSPRTEPPQGEDQVDICNLRSKLRPAK APEKASLDGEAHPAPGGQDAVFSRNFLSGEAPGRVQDRLGRQDGLSPKEAACRAPPRPAKNTEPTPKTVP VPLQEAQRPAVPPRRPPPPKKTSGSSSSRPLPEVRSPQREAHDSKAAPAPGRPLLVPPKAKPFLSNSPGG QEDVRGPWGAGRVGDHREKAIAASFPNADGPKDSLYVAVANFEGDADTSSFQEGTVFEVREKNSSGWWFC QVLSGAPSWEGWIPSNYLRKKL >XP_002816245.4 SH3 and PX domain-containing protein 2B [Pongo abelii] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSG EPLPPKPGPGSPSHPGALDLDGVSRQQNTVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGAMDSGLPWSKDWKG SKDVLRKASSDMSASAGYEEISDPDVEEKPSLPPRKESIIKSEGELLERERERQRTEQLRGPTPKPPGMI LPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAT PQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRPAKSQDKPLLDGEGPQAVGGQDVAFSRSF LPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPQQRPVVPPRRPPPPKKTSS SSRPLPEVRGTQCEGHESRAAPTPGRALLVPPKAKPFFSNSLGGQDDTRGKGSLGPRGTGKIGENREKAA AASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK P >XP_020932748.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Sus scrofa] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GGQDEFALQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSG EPSPPKPGPGSPAHAGVPELDGITRQTGREKELLNNQRDGRFDGRPAPDSDMKQRSPKMRQRPPPRRDMT IPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFID KYKKTSNASRPNFLAPLPNEVPQLRLGEAAAMENSVSSEATGPSRPLPEAPHGAADSGMPWSKDWKGGKE VLRKASSDMSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERERQRMEQLRGASPKPPGMILPMIP AKHAPPGRDSRRPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPVSKSKADPPEERPEAVPPNPF LKSKPQVRPKPAPSPRTEPAQGEDQVDICNLRSKLRPAKSQEKPSVDGEGGHQAGGGQDMAISRSFLPGE GPGRPQDRTSKQDGLSPKEPTCRAPPRPGKTAEPVPKNAPVPLPQASQQRPVVPPRRPPPPKKTSSSRPL PEVRGPQREASEVKAAPAPGPGRALLVPPKAKPFLSTSPGGQDDMRGKGGLGPRMTGKXGENKDKGAAAP CPGADGPKDSLYVAVADFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP >XP_019475954.2 SH3 and PX domain-containing protein 2B [Meleagris gallopavo] MRDAERSAGSAGRGNGAGFVGSVRAPLSAPGQRRKAHLSAALRVLNFKHNQEESEKIGFLMVYIIKVTWS NGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKA LIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKRSGFIQRTTSFLQRGADSASVDPLVLEQYVVVAN YQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDELSMQPDEVPWRYWSLPR HVGRRRTLGDLYTSGWGQEEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQGQEGWAPASY LKKGNGEFSQKLGSGSSTHSCALDLDGISRQQVVTSREKDGQRDGRFDNRPLPNADIRRKSPKMRQRPPP RRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAP ATFIDKYKKTSNASRPNFLAPLPSEMAQLRLGDAAAESSATEEATGPCRPLPEAPPNGMDCGTKWAKDWK GKEATESGDLAFTCGYEEISDRDVEEKPSLPPRKESIIKSEGELLERQRPPPKPPGMILPMIPPKQSAAP KDSKKPELKSEKSKLFQLKNEMGLECGHKVSAKEVKKPNLRPIVKPTKPKAEPVEDKPEPITQNPFLKSR PQIKPKPTAAPRTDPPPADDKLDICSLRSKLRPAKCPEKPPEQDTTASESSCSNPAVAPEASGRFQERPS IESKALPKSPPGPAVPLAARELAPQRPVVPPRRPPPPKKTTSPVAGPPPEARASPLPGRPMLVPPKARPF LSAAIQDEAKVKSSVGPKVISKAVERGEGRERTSAPFSNPDVSKEALYVAVADFEGDEETNSFREGTLFE VREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKKP >XP_034816856.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan paniscus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQ KNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSE ATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKS EGELLERERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKV LAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRP AKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGSGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKS VPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEVRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSL GGQDDTRGKGSLGPWGTGKIGENREKAAAASVPSADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKN SSGWWFCQVLSGAPSWEGWIPSNYLRKKP >XP_023115375.1 SH3 and PX domain-containing protein 2B [Felis catus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GMQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKSSG EPSPPKLGPGSSAHTGVLDLDGVSRQQSPVGRERELLNNQRDGRFEGRPGPDSDIKQRSPKMRQRPPPRR DMTIPRGLNLPKPPVPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPNEVTQLRLGDAAAAENNTGSEAVGPSRPLPDAPHGTADSGMPWSKDWKG GKEVLRKASSDMSSCAGYEEISSPDLEEKPSLPPRKESIVKSEGELQERGRQRMEQLRGSSPKPPGMILP MIPAKHTPPSRDSRRPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRPKAEPPEEKPEVVPQ NPFLKSKPQVRPKPTPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKPLLDGESGHQPAGGQDAAFSRGFL PGDGPGRTQDRTAKQDGLSPKEMSCRAPPRPAKTADPVPKSVPAPLQEASPQRPVVLPRRPPPPKKTTSS SRPLPEVRGPQREANEGKTAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGPGPRMAGKIGENREKVAA TPFPNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP >XP_027835791.2 SH3 and PX domain-containing protein 2B isoform X3 [Ovis aries] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSG EPSPPKLGPGSPAHVGVLELDGVSRQQNSAGREKELLNNQRDGRIEGRPAPDSDIKQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPSEVAQLRLGDTAATENSSGSEAGGPSRPLPDAPHGAGDSGTPWAKDWKG GKEMLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERQRMEQFRGSSPKPPGMILPMI PAKHAPPARDSRKAEPKPEKSKLFQPKNETGLECGHRVLAKEVKKPSLRPVSRSKAGPPEEKPEAVPQNL FLKSKPQVRPKPAPSPRTEPPQGEDPVDICNLRSKLRPAKSQEKASVDGESSLQAGGGQDGAFSRGFPPG EGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEASLQRPVVPPRRPPPPKKTSSSSR PLPEVRGPLPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKG GLGPRMMGKMGENKEKVAAGPFPSTDGPKDLYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQS GAPSWEGWIPSNYLRKKP >XP_030867156.1 SH3 and PX domain-containing protein 2B isoform X1 [Gorilla gorilla gorilla] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKK KSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEVSWRYWSLPRPVGRRRTLGDLYAISWRQEEKYTVIYPYTARDQDEMNLERGAVVEVIQ KNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRD GRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAG LKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSE ATGPSRPLPDAPHGVMDSGLPWSKDWKGSKDVLRKASSDMSASAGYEEISDPDMEEKPSLPPRKESIIKS EGELLERERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKV LAKEVKKPNLRPISKSKTDLPEEKPDATPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRP AKSQDKSLLDGEGPQAVGGQDVAFSRSFLPGEGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKS VPVPLQEAPQQRPVVPPRRPPPPKKTSSSSRPLPEIRGPQCEGHESRAAPTPGRALLVPPKAKPFLSNSL GGQDDTRGKGSLGPRGTGKIGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKN SSGWWFCQVLSGAPSWEGWIPSNYLRKKP >XP_043743513.1 SH3 and PX domain-containing protein 2B [Cervus elaphus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKI LFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGGDLTSVDPMVLEQYVVV ADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVSRQQNSGGREKELLNNQ RDGRFEGRPAPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEK NLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHGTGDS GTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERQRMEQFRGSSPKPPGMILPMI PAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPEAVPQNLFLKSKPQVRP KPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFGRGFPPGEGPGRPQDRTSKQEGPSPKE APCRAPPRPAKTTDPVPKSAPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPDVRGPLPEVRGPL PEVRGPQRESSESKAASAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGPGPRMMGKSGENKEKVAAGPFPNTDGPKDLYV AVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP >XP_043344822.1 SH3 and PX domain-containing protein 2B [Cervus canadensis] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKI LFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGGDLTSVDPMVLEQYVVV ADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEM NLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVSRQQNSGGREKELLNNQ RDGRFEGRPAPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEK NLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSTGDS GTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERQRMEQFRGSSPKPPGMILPMI PAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPEAVPQNLFLKSKPQVRP KPAPSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFGRGFPPGEGPGRPQDRTSKQEGPSPKE APCRAPPRPAKTTDPVPKSAPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRGPLPDVRGPLPEVRGPL PEVRGPQRESSESKAASAPGRALLVPPKAKPFLSNSSGGQDDMRGKGGPGPRMMGKSGENKEKVAAGPFPNTDGPKDLYV AVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP >KAB0369849.1 hypothetical protein FD755_018842 [Muntiacus reevesi] MLFIFIYAHAVSPAHSSLMESEALPMDSSASNNTQPLGFISVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGG QKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGG DLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEE KYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVS RQQNSGGREKELLNNQRDGRFEGRPVPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIP DGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEAS GPSRPLPDAPHGTGDSGTPWAKDWKGGKEVLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERQRMEQ FRGSSPKPPGMILPMIPAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPE AISQNLFLKSKPQVRPKPASSPRTEPPQGEDQVDICNLRSKLRPAKSQEKASVDGESSHQAGGGQDGAFSRGFPPGEGPG RPQDRTSKQEGPSPKEAPCRAPPRPTKTSDPVPKSAPVPLQEASLQRPVVPPRRPPPPKKTSSSSRPLPEVRGPLPEVRG SLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDVRGKGGPGPRMMGKSGENKEKVAAGPFPN TDGPKDLYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKKP >XP_018107654.1 SH3 and PX domain-containing protein 2B isoform X4 [Xenopus laevis] MPSRRSIVQVCVQDVQKRRSPNKHYVYIIKVTWSNGTTEVIYRRYSKFFDLQMQILDKFPVEGGQKDPKQRIIPFLPGKI LFRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARVEDFNPPKEEPFGRKKLGGDSSSSDALVLDQYVVA AAYDKQESSEISLQVGQVVDIIEKNESGWWFVSTADEQGWVPATCLEAQDGGQDDFTIQPEEEEKYIVVYPYTARDQDEI TLEKGYVVEVIQKNLEGWWKIRYKGSEGWAPASYLKKVSGDLLSQKLAAGSGANSSALDLDGITRQHSFTGQERESPAHL REGRIDTRPPHFADIKRKSPVLRQRPPPRRDLTIPRGLNLPTPPTPPHVEEEFYTIADFQTTIPDGISFQAGLKVEVIEK NHSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPNEMAQLCLGDANAENNTEEEATGPCRPLPEPPQNGTDST SKWSKDWKGKDPGLKGIQINGRDLGANSVYDEAAGDLEEKPNLPPRKESMLKTDDASERTSMHQLRVPPSKPPSSLMAPI PQKIIPSKETRKPELKNDKNKIFQLKNEMGIECGHKVSPKELKKPMLKPVANKPKPEPPTEKPDSIAPNAFLKPKPVVRP KPVTAPKTDPHNDDKVDISNLRSRLKPASKSIDKPNDQEFAGNGASSYPTSTSGAAGRPQDRPDLRPLQKQDGDGTREPP FKALPVPSRTVDSDLKGGMVSGKEPPQRPMIPPRRPPPPKKASVSSDTTEGKIQKDSELTSSPLGNRPIMVPPRARPFNL SSSNDDTKVKPSFVPKTQVPRQMDKEIREKPGFSLPTPEVSKETHYVAVADFDGDEDTSSFKEGTVFDVQEKSSGGWWFC RVLSGGPAWEGWIPSNYLRKKP >XP_023818605.1 SH3 and PX domain-containing protein 2B isoform X1 [Oryzias latipes] MPRRTVQEVTVQDVQKRRTPNKHYVYIIKVCWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRR IIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRIFFETRPEDLNPPKEELMVKKK PGFVERATTFLKRGDSTSGDALLLDQYVAVTDYEKQESSEISLRVGQVVEVIEKNESGWWFVSSEDAQGW VPATCLEVQDDPDDFTLPGEEVPRRFWSFPRHVGRRRTLGDLFSTGFGQEEKYSVIYPYSARDQDEIDLE RGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKSDIQSQRQSAGAAAHASANDLEGISKQSPQNNAKEN RLSLFSDNNKSKVGSRHRPPPRRDLTIPRGTNLPKPPVPPLVEEEFYTIADFQTTIPDGISFQAGVKVEV IEKNGSGWWYIQIEEKEGWAPANFIDKYKKTSNALRPNFLAPLPNEMEKLCLEDGGSSNVTDTDDTWSKP LPDEPTTAQDTHTRPKLRDWKSGFSGPLPPAPAAPPIEEKPALPPRRESINKSFEFEGVEKPRSDHPKPL PPKPPAPGVIVPLVTPKTAPFKPDKPPEAKKEDKSKALYLKNEMGLECGHKVSAKEVKKFNLKPVPKQPP KPKSDVQEEKPEVAGPAVLMKAKPVIRPKPAPAAKPEALAEKKVDITNLRSKLRPSKPLDQGSAEGNHQN ETVEPGNGSSPIQIPTLNSDKSSDESKITSKHRNALRKDSSSPPSKPGVPPHKEPPQRPTMGPRRPPPPK KAEQLGHTETKPQVMKEPQEIPKNGLPQLSRPPPPKPKGFPQPPASKEKDECKGNKLPIPPKPQLKSEKP GPPKDKLPPLLKDSSKEELYLAVADFEGDEQTSSFKVGTVFEVLEKNSSGWWFCKNVGEDSEGWIPSNYL SKKP >XP_021152892.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Columba livia] MAQLPGVPGLSWVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFR RSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEXPIGKKRSGADSASADPLV LEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDEFSMQPDEE EKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGEMFSPKLGSGSSA HSCALDLDGISRQQVMVSREKDGLAGQRDGRFDSRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKP PVPPQVEEEYYTIADFQTTIPDGISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASR PNFLAPLPNEMAQLRLGDATADSSTGEEVTGPCRPLPEAPPNGTDCGGKWAKDWKGKEAPESGDLALTSG YEEILDRDAEEKPSLPPRKESIIKSEGELLERQRPPPKPPGMILPMIPPKQSVAPKDSKKPELKPEKGKL FQLKNEMGLECGHKVSAKEVKKPNLRPIVKPTKPKAEPVEEKPEPIAQNPFLKSRPQIRPKPAAAPRTDP APADDKLDICSLRSKLRPAKCPEKPSEQDTAAGESSLANATVSSEASGRFQERPSVESKPLPKVDSHAMK EVLPKSPLGPANTPGARDPPPQRPVVPPXXXXXXAELRAPAREAPEIRSSPVPGRPMLVPPKAKPFLAAS IQDEAKVKGSISPKVISKPVERGEAKERTSAPVPSPDISRDALYVAVADFEGDEETNSFKEGTLFEVREK NSSGWWFCKVLTGGPCWEGWIPSNYLRKKP >XP_017921047.1 PREDICTED: SH3 and PX domain-containing protein 2B [Capra hircus] MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQ RIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKK KSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQD GVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSG EPLPSKLGPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRIEGRPAPDSDIKQRSPKMRQRPPPRR DMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPAT FIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAATENSSGGEAGGPSRPLPDAPHGAGDSGTPWAKDWKG GKEMLRKASSDTSSCAGYEEISDPDLEEKPSLPPRKESIIKSEGELQERQRMEQFRGSSPKPPGVILPMI PAKHAPPARDSRKAEPKPEKSKLFQPKNETGLECGHRVLAKEVKKPSLRPVSRSKVGPPEEKPEAVPQNL FLKSKPQVRPKPAPSPRTEPPQGEDPVDICNLRSKLRPAKSQEKASVDGESSLQAGGGQDGAFSRGFPPG EGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEASLQRPVVPPRRPPPPKKTSSSSR PLPEVRGPPPEVRGPLPEVRGPLPEVRGPQRESSEGKAAPAPGRALLVPPKAKPFLSNSSGGQDDMRGKG GLGPRMMGKTGENKEKVAAGSFPSTDGPKDLYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQS GAPSWEGWIPSNYLRKKP >XP_014374200.1 SH3 and PX domain-containing protein 2B [Alligator sinensis] MPLLKADEEMLRIPWVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKI LFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKKSGFIQRTAS YLQRGGDFASVDLVLEQYVVVADYQKQESSEISLCVGQTVDIIEKNESGWWFVSTSDEQGWVPATCLEAQ DGVQDEFSMQPEEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWAPASYLKKGS GEMFTQKLGSGSSTHSSALDLDGISRQQNSAGREKDGPNNQRDVRFDGRLQPNADIRRKSPKMRQRPPPR RDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGMKVEVIEKNLSGWWYIQIDEKEGWAPA TFIDKYKKTSNASRPNFLAPLPNEMVQLRLGDVTVEDSASEEATGPCRPLPEAPPNGMDCGTKWAKDWKG KDSLESGDLAVASGYEEIPDQDIEEKPSLPPRKESIIKSEGEFMERQRPPPKPPGMILPMIPPKQTPAPR DSKKPELKTEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPIIKPAKPKAEPLEDKPEPTTQNPFLKSRP QVRPKPAPAPRTDLPPVDDKLDICSLRSKLKPAKCQERSSEQDPGASENSFSNNALPADAPGWPQEQPSA ENRPLPKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPPPQRPVVPPRRPPPPKKATPCSSGSTSD LKAPQREVPDLRAASVPGRPMLVPPKAKPFLPALGQDEAKVKSNLGPKVTPRQVERGEAKERTAAPFPNP DISKEALYVAVADFEGDEETNSFKEGTLFEVREKNSSGWGFCKVLTGGACWEGWIPSNYLRKKP >XP_014453036.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Alligator mississippiensis] MPRRSLVEVKVLDVQKRRVPNKHYVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQR IIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKK SGFIQRTASYLQRGGDFASVDLVLEQYVVVADYQKQESSEISLCVGQMVDIIEKNESGWWFVSTSDEQGW VPATCLEAQDGVQDEFSMQPEEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWA PASYLKKGSGEMFTQKLGSGSSTHSSALDLDGISRQQNSAGREKDGPNNQRDVRFDGRLQPNADIRRKSP KMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTIPDGISFQAGMKVEVIEKNLSGWWYIQI DEKEGWAPATFIDKYKKTSNASRPNFLAPLPNEMVQLRLGDVTVEDSASEEATGPCRPLPEAPPNGMDCG TKWAKDWKGKDSLESGDLAVASGYEEIPDQDIEEKPSLPPRKESIIKSEGEFMERQRPPPKPPGMILPMI PPKQTPAPRDSKKPELKTEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPIIKPAKPKAEPLEDKPEPTT QNPFLKSRPQVRPKPAPAPRTDLPPVDDKLDICSLRSKLRPAKCQERSSEQDPGASENSFSNNALPADAP GWPQEQPSAENRPLPKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPPPQRPVVPPRRPPPPKKAT PCSSGSTSDLKAPQREVPDLRAAPVPGRPMLVPPKAKPFLPALGQDEAKVKSNLGPKVTPRQVERGEAKE RTAAPFPNPDISKEALYVAVADFEGDEETNSFKEGTLFEVREKNSSGWWFCKVLTGGSCWEGWIPSNYLR KKP >XP_015816888.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Nothobranchius furzeri] MPRRTAQEVIVQDVQKRRIPSKHYVYIIKVSWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRR IIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKR AGFVERTTTYLKRAGDSNSADPLLLEQYVAVTDYEKQESTEISLHVGQVVEVIEKNESGWWFVSSEDAQG WVPATCLEAQDDPDDFTLPGEEVPRRFWSLPRHVGRRRTLGDLFSTGFGQGGAHAFLFPTILKEKYSVIY PYSARDQDEIDLEKGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKADIQSQRQSAGAAAHASTNDLEA FSKQNQQNNAARENRDNQKENRLSFFSDNKKVGLRHRPPPRRDLTIPRGTNLPKPPVPPQVEEEYYTIAD FQTTIPDGISFQAGVKVEVIEKNASGWWYIQIDDTEGWAPATFVDKYKKTSNALRPNFLAPLPNEMEKLR QEDGGSSNVSGKDDTWSKPLPDEPTTGSESCARPKLRDWKSNPSKGTSAFSGPLPPAPAAPPAEEKPALP PRRESINKSFELEVAEKAKSDHSKPLPPKPPAPGVIMPHVAPKMPPFKPEKPTEVKKDDKNKALYLRNEM GLECGHKVSAKEVKKFNLKPVPKQPPKPKPEIQEEKPEAAGPASFIKAKPVIRPKPAPAAKPEGQADDSK LDITNLRSKLRPSKPADLGSASAEVNHQNDTSATGNGFHPSSPPSSPSVHIPSVNNGKCSEPKLPTKHTN GLSQERSSPSAKPAVPPHKELPQRPPTMAPRRPPPPKKTDPSSPTEPKSPPTLKEPQEVPRPGPPQLSRP PPPKPKGFVHPPVSKENNEPRVNKVPIPPKPQLKSEKPGPPKDKLPPLLKDSSKDELYLAVADFEGDEQT SSFKVGTVFEVLEKNSNGWWFCKNVGEEVEGWIPSNYLSKKP >XP_030294651.1 SH3 and PX domain-containing protein 2B isoform X1 [Sparus aurata] MPRRTVHEVTVQDVQKRRNPNKHYVYIIKVSWSDGSTEVIYRRYSKFFDLQMELLDKFPVEGGQKDPKRR IIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKK SGIVERATTFLKRGDSSAGDPLLLDQYVAVTDYEKQESSEVSLHVGQVVEVIEKNESGWWFVSSEDAQGW VPATCLEAQDDPDDFTFPGEEVPRRFWSLPRHMGRRRTLGDLFSTGFGQEEKYSVIYPYSARDEDEIDLE RGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKSDIQSQKQSAGGAVHASTNDLDSKQNQQNNAAKENR DNGHKENRLSFFSDKKVGSRHRPPPRRDLTIPRGANLPKPPIPPQVEEEFYTIADFQTTIPDGISFQAGI KVEVIEKNASGWWYIQIDDKEGWAPATFIDKYKKTSNALRPNFLAPLPNEMEKLSLADGVSSNASGTDDS WSKPLPDEPPTAPESCARPKLRDWKSGPSKGGCGPLPPAPAAPPVEDKPALPPRRESINKSFEVEVAEKP RPDHSKPLPPKPPAPGVIMPMVPPKAPPPLKQDKPPETKKEDKSKPLLLRNEMGLECGHKVSAKEVKKFN LKPVPKHPPKPKSEAPEEKPEAAGPAVFMKAKPVLRPKPPPAAKPDPPSENKLDITNLRSKLRPPKPADL ETPAAGNNPQPSPSSPVHIPSLNNGKHCDEPKLPPKHINGHSQESSSPPAKPAVPPHKEPPQRPPAMAPR RPPPPKKETPSSPTELKPPPAPKEIQDVPKIPPPQLNRPPPPKPKGFVAPPPNKEKEEPKVNKVPIPPKP MLKSEKPGPPKDKLPPLLKEPSKDELYLAVADFEGDDNTSSFKVGTVFEVLEKNGSGWWFCKNVREEVEG WIPSNYLSKKP >XP_040200471.1 SH3 and PX domain-containing protein 2B isoform X1 [Rana temporaria] MSRKSIVQVNVQDVQKRRSPNKHYVYIISVSWSNSSSEVVYRRYSKFFDLQMQLLDKFPVEGGQKDPKQR IIPFLPGKILFRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARLEDFNTPKEEHIGRRK FGADSASADPLVFDQYVVVAPYDEQESSEISLQVGQVVDIIEKNESGWWFVSTADEQGWVPATCLEAQDG GQDDFTIQPEEAPWRYWSLPRHVGRRRTLGDLYTSGWGPDEKYSVIYPYIARDQDEITLDKGVIVEVIQK NLEGWWKIRYKGAEGWAPASYLKKISGDLLAQKLASGSSANSSALDLDGLSRQQNFTSRDRDVPGRQAHV TDFKRKSPILRQRPPPRRDLTIPRGLNLPKPPTPPHVEEEYYTIADFQTTIPDGISFQAGLKVEVVEKNH SGWWYIQIDDKEGWAPATFIDKYKKTSNALRPNFLAPLPNEMAQLCLSNASTENTSVEEASGPCRPLPEP PQNGTDPVSKWSKELKNKDPGFKSSPLDGKEHFSNSVYDEAAVDDGEEKPSLPPRRESMLKTEEVSERPS MPQHRAPPPKPLTSMMASSPQKQLPSKEVKKPEIKNDKSKMFQLKNEMGLECGHKVSPKELKKPMLKPVA NKPKPEISSEKPELMVPNPFLKAKPQVKPKPVATTKTEGSSEDKVDISNLRSRLKPSGKSLDKGNEQEPC ASSGVSDTKVYNCIGAAGRPFDKPDQKHLYKQNNSIPGEPPSKALPVPLRTVDTEPKAARDLPQRPVIPP RRPPPPKKVSMSCETNEGRATQIKESSDFTVAHMANRPIMVPPKSKPLISLPGSDDTKVKNSFVPKMPAS RLADKSETKEKPVSSTPPSQYVAVADFDGDEDTSSFKEGTIFEVQEKSSNGWWFCRVLSGGPTWEGWIPS NYLRKKP >XP_038045303.1 SH3 and PX domain-containing protein 2A-like isoform X4 [Patiria miniata] MGRRTVQDAIVDDIQKRKYPTKHYEYVIHVSWSDGSVNVVYRRYSKFFDFQMKLLSIFPEEAGARNPTQRMIPFLPGKKL FGRSQTREVASRRLGQLNEYCQLLVRLPPKISESDEVLQFFTPTAEDINPVTERGVIKKGAKEIDVISDPIQPDPYIVIA DYKKQQKNEVDLHTGDNVEVFEKNDNGWWFVSSNDSQGWAPATFLSRADGGDDEDGLAGGGTEERYISNNSYKAQQEDEV SFETGVVLIVMQKSLDGWWKVRYKEKIGWVPAAFLQVYTGPADVTASTPTQRVGNVMSVSDIISRRQAADSSKNSPMLGR KDNLHSHGTEAKPTPPRRTTVRPGQKTDDERTVRKGATRKRRPTATKKTLEYYTVADFSDSAGDSISFKSGQKVQIIQET ESGWWLVKIGDEEGWAPSSYMEAKEETVAETRPQPSNRESLDEETGESSPRPPRPPPPTGRKISNGGATSSSSGTGGFRP VSTPGGSKSSGAASAFRPVSMPSSNNGRPLPVTPAFKPAPPALKPTPQTQPKPFRPSSGGGSNLIQNAQANLKPVRSQSK PPLVNRQKKPGAQPNGSPIGTPGSNVQPSQIADLQNQLKSLKTPSSGGVRDRRPSNAYVTTAAYENVDDDDGLSFEEGVQ VEVIEENDTGWWLVRIAGEEGWAPSTYLEKA >XP_030842214.1 SH3 and PX domain-containing protein 2A isoform X3 [Strongylocentrotus purpuratus] MGKRTVVNANVTDIEKRREPTKHYVYIIHVTWSDGSVNVVYRRYSTFFDFQNKLLSKFPEEAGANNPSSRCIPFLPGKKL FGRSHIREVALKRLSPIDEYCTALVKLPGKISDSKEVINFFTPTPEDVSPPSPDGGGESTRGRADIGNISEPIQAEQYIV VADYKKQQKNEVELTAGDLVEVFEKNDNGWWFVTVHDQHGWAPGTFLQNPDGQEEEDEETLIPGNDESYITNNAYQGQAE DEISFETGVVVTVIQKSLDGWWKVSYQGKQGWAPATFLQIYKGPSGVTPKHPTQSIGNVMLLKSGSDSKPKPGPGPGSSG RPQPPVQPRDEPGQLYSNYDAEVKPTPPRRATVKKSVRRGGVRQTKPKLKKVMEHYTTDSFQGAAGEGSISFESGQKVEV LEENDGGWWYVKMNGQEGWAPSNYIEKREVSSRINGKPSLGNLDEETGEDKVPPVLPARPAFGSGGSGAFKPVAKKSTPP PVDRSNSPSFTNRKAVTNNGRGGGDGVRRGSGGVGAGGNMMAALKKQLEKSSVGESSSPAIPARPGVAPKLSKPTAQPYC NRDAAYITTSSYVNDENDGLSFKEGQRVEVIKKDDSGWWSVRIGNTEGWVPNTFLEKI >XP_031561245.1 SH3 and PX domain-containing protein 2A-like [Actinia tenebrosa] MVKRTLTSVKIVDIQKRKVPSKHYVYVISVTWSDGSVNVVYRRYSKFFDLQTKLLEEFPVEGGVQNPSTRVIPFLPGKII FGRSHVRDVALKRKESIDEYCSKLIELDPKLSQSDLVLKFFEPSSDDIDIPAEKKKKKNETADNISDPISLDQYVAIADY QKQNRNEISMAAEDVVEVIDKNENGWWFVNLDEEQGWVPAAYLEPLDGPSDDMDFTDVSSVEENQFITTTSHIAELDDEI SFEMGVIVTVVKKNFDGWWLIRYQNKEGWAPAMYLKKPDPMQLHAAEIGGAVPKRDSVPVITHAPIMQQPTSNLARKGKG VPPRKASVKRSIRKPFSIANQSYEKHFEPVKETAAIHSEAEYVTIGDFRAVDIQSGLSFDKGEAVEILDKSPNGWWLGKI GGHEGWIPSSYVEKRNRSQKGNVVTPKPDRPQLPSSRLSISEIKPETSQSPDLKSDLNIALSSMRLKSCAASEPAEPSGQ SSTKEMYAAVSDFEDSSDGVVCLKEGDVVEVVDKSEGEWWLVRLNEKQGWVPSSYLTKQEIKNSPAPRRPKPPASKPSSS SQGASKPALPAIPSSKPVSSQKMNKKPLLPSVPSGKPGTLRKTDGKPLPSPVLSGKPATLQKTNGKPTPPPVPSAKPTLA QKPKAKPSPHPVPKGKPAFPQKTTAKPVPPPVPSTKPSVSQKPMALPVSSRNPQRDSLQNQQHKPVFPLKPVKQNSPVSN KKDDNINRPKKIGKLNTALFESKIPIFAPQLDETPKQAETPSKKIPPTTEKPTRNEPAKPSASQCVAIAAFTNTDQDGLS FSEGDLFDFLEDSGSGWWLVKTQATNREGWAPSSYLEMKTPDNITPIANQTNRPQRRDPPDPPKRPDSSKPAKQFYVAIA TFCEDDETSVSFQEGDTIEVLQQDDGGWWMVKVNDETGWAPSNYLQPL >CAE1310922.1 SH3PXD2 [Sepia pharaonis] MRKSVTAVEVVDVEKRRLPSKHYVYVIQVTWDDGSSITIYRRYSNFFDLQTSLLETFPEEGGQLNPDERTIPFLPGKKYF GRSHIREVAEKRLGPIDKYCKLLIKLDKKISQCHEVLTFFEPTADDLSPKSQEKKPGEAKISKPKVLEQYEAIFDYQKQA KDQVDLKVGQSVQVIEKYETGWWLVNTEYEEGYAPGTFLQKTDGQEEEQMFTCNGEKYICIQSYTAEVPDDHTLNIGAEV EVLQKSLDGWWWVRYKGKIGWAPATCLKVADSISRHSANIPVEIVSNLSDVSKLLKGNDTTADSPMTVSQRPKSAAETYT YFSSASVQDSDNYEEVEESHYSHINSIYGNTSHTVVPPPRQKSIRDKGKVPMNAEENKTKFITCAEYIDSVGDGISFSAG QEVEVQQKTDSGWYYIKLGNEFGWAPSSYLEEIPLDETHSSVRFDKIQEEKAEEDDDDDDDDDEYETINLCPAKQIENIL VSKLTPAHSPSNSQIDGLERNSSSSDELKLPLSSSPTGSSSSACPSTNSSLSRTAVKRPNSIPPAPPKRPDHPGGQPPLP SVPPVSSATKINPQLPPPPPPPSSVPKKPVPPSSTGLYKSSKTSATCPPQPPPPPPGRPYSGISHPLVTNSVADHSKETS NTSGNLATELQSRLAKLKANFDSGSSANTKKQQPLTKEKPVIIHGVNIKGGATSVAGNNSKVTKTKDIKKSQPQVFLPHV QKTTPILPASPSNVDNSPSQAEKDDIQRIPVPNVSDSSVVVPSSKFAEKLSVFQMNTNGDNAAATPKFSSPNVPLASNCR GLALLQRQKDKLMEEAESNCKASNESLEHEAKVSNLRNNFESSTCKLSTSSSVPPDQSTNVKPAPPTKPIHKVKPTTVPA KANPNLPVKPKVSPCKPKFGAVTNTGKKDSTTNIANKINKFGGNNMASPAKISAAEMEPPKFQLVKEKVMTPTNQTQQNT AKEMRTSNTDFNINSVIQRAPKSTDRSYKASSRYIAESEGEVSFEKGVDIEVLEKHESGWWLVHIGDEEGWAPSNHIAEL KPLPPTKPLPPNKPLPKLPSSPSTKSTGQTAKPVISINTTSPNLSFNCRDHRRPFPFVLFFFLHQKYL >XP_039260717.1 SH3 and PX domain-containing protein 2A-like isoform X2 [Styela clava] MPGTVGRRTLVKVEVGDAEKRRIPSKHYSYVIKVWWDDDSETVVYRRYSKFFEFQIILLETFPYEGGLKEPSARIIPFLP GKILFRRSHVRDVAMKRLKPIDEYCKALIKLPSHISKCNHVLDFFETRQEDLNPSREEGSRRRKRDDQEIGEISGPLLLE QYVAIADYNSTQQKELTMTIGQKVEVIEKNENGWWFVSNDEGERGWVPGVYLEKPDGTVEDLVTNRAEPGQGEHYVTTNA YVAENSDDISFGAGVIVEVLQKNLEGWWLVSYNGRQGNAPASYLEKSHNWVPENNKVEIISSIHDLKHRHSLPANSLSSI AFPSQRIVNFSSSNSKPIPAEVHSIPEEPKSPVSPSYFREKTVQPPPKKSSVKRTNKRRPMAPPPLPPSAAAEPTYEYTT VASFDSNIPDGISFKDDKKVEVLEKSPGGWWYVNIDGSEGWAPASYIEKKETKPKTIVPPSRPGPPKLLKNNSTNSFSIT AAGRSSPVHKVQSSDTVNHPVLGKVASIPILRNQSSMSPAKRPLPPLPTSVSSSNVQDCSDTYEEVATRPLSENIKFGAS KSIPPAVPKSTAKPNLNKTAIESQKVETTPVDFRSVLKSSLAKKNEIKTRSAQSPPRPSTNPSPLSNVMKPKIQPNNINL RPKTTTSTQKPSNVRNSVTRMNSNETSSAVNNLKPVFGGKTAEGPPRLPPKPKPGLNSVKAKPVQGNVPTNDDAITDFRS VLRSTQRKQSASTNGVGRSKSFNSDKVISTKKVEQGNKPPFVPKKPANMPLKPPVPTKMKELDEFSGGEENNPKAPGKRN TTTTRPPWNSGPGTKPVIRRFQTNNNSNVDEVQKKPVFTVGHLKIELKNPPDLTKSLPKRGSPDGQVDCKFEDTSKSNTI TPPTRTKKILKSKHNPKNSKSVSKTNLQKTESNDSSSNFCIAMSDYTGIEECEISFQSGDRAELLEKGDNDWWYIKMGEN VGWAPSTYFKLTCEEESSEKDYVAVDGSSNAKSDQESFYNKIEPERPSFPSKFVAVADFEADNHSMVSLHAGDEVTITQE ASGGWWYAILSNGNGEGWVPSSYLDPVE
Mafft alignment of selected proteins >sp|A1X283|SPD2B_HUMAN SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3 ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL---DGVSRQ--QNAVGREKELLSSQ RDGR-------FEGRPVPDGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VTQLRLGEAAAL--------------------------ENNTGSEATG PSRPLPDAPHGVMDSGL----------------------PWSKDWKGSKDVLR------K ASSDMSASAGYEEISDPD-------MEEKPSLPPR-KESIIKS--EGELLERERERQRTE QLRGPTPKPPGVILPMMPAKH-IPPARDSRRPEPKPDKSR-------LFQLKNDMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKTDLPEEKPDATPQN PFLKSRPQVRPKPAPSPKTEPPQGED---QVDICNLRSKLR--PA-KSQDKSLLDGE-G- PQAVGGQDVAFSR---SFLP------G-EGPGRAQDRTG--------------------- --------------KQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAP--QQR-PVV PPRRPPPPKKT---------------------SSSSR----------------------- -----PLPEVRGP--QCEGHESRAAPT-----PGRALLVPPKAKPFLSN-SLG-GQDDTR ----GKG-SLGPWGTGKI-----GENREKAA----AASVPNADGLKDSLYVAVADFEG-- DKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >NP_796338.2 SH3 and PX domain-containing protein 2B [Mus musculus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDL---DGVSRH--QNAMGREKELLNNQ RDGR-------FEGRLVPDGDVKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSA----SRPNFLAPLPH E-----------MTQLRLGDAAAT--------------------------ENNTGPEAVG PSRPLPEAPHGAVDSGM----------------------LWSKDWKGGKEAPR------K ASSDLSASTGYEEISDPT-------QEEKPSLPPR-KESIIKS--EEEL--LERERQKME PLRGSSPKPPGMILPMIPAKH-APLARDSRKPEPKLDKSK--------FPLRNDMGLECG HKVLAKEVKKPNLRPI--------------------------SRSKAELSEEKVDPTSQN LFMKSRPQVRPKPTPSPKTEPAQSED---HVDIYNLRSKLR--PA-KSQEKALLDGE-S- HHAAGSHDTALSR---SFLP------G-EGPGHGQDRSG--------------------- --------------RQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEAT-LQQR-PVV PPRRPPPPKKT---------------------SSSPL----------------------- --SCRPLPEVRGA--QRE--ESRVAPA-----AGRALLVPPKAKPFLSN-SSV-GQDDMR ----GKG-GLGPRVTGKV-----GETREK------AASFLNADGPKDSLYVAVANFEG-- DEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_017453105.1 SH3 and PX domain-containing protein 2B isoform X1 [Rattus norvegicus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPVEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEEVSWRYCSLPRSVGRRRTLGDLYA ISWRQ------------EEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQG KEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDL---DGVSRQ--QNAVGREKELLNNQ RDGR-------FEGRLAPDGDVKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSA----SRPNFLAPLPH E-----------MTQLRLGEAAAT--------------------------ENNTGPEAVG PSRPLPEAPHGAVDSGM----------------------LWSKDWKGGKEAPR------K ASSDLSASTGYEEISDPT-------QEEKPSLPPR-KESIIKS--EEEL--LERERQKME PHRGSSPKPPGVILPMIPAKH-APLARDSKKPEPKPDKSK--------FPLRNDMGLECG HKVLAKEVKKPNLRPI--------------------------SRSKAELPEEKVEPNPQN LFLKSRPQVRPKPTPSPKTEPAQGED---QVDIYNLRSKLR--PA-KSQEKALLDGE-S- HHAAGGHDTALGR---SFLP------G-EGPGRGQDRSG--------------------- --------------RQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEAT--QQR-PVV PPRRPPPPKKT---------------------SSSPL----------------------- --SCRPLPEVRGS--QRE--ESRAIPA-----SGRALLVPPKAKPFLSN-SSV-GQDDIR ----GKG-GLGPRIAGKV-----GETREK------AASFLNADGPKDSLYVAVANFEG-- DEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_025010804.2 SH3 and PX domain-containing protein 2B isoform X1 [Gallus gallus] ----------------------------MP----RRSI---AEVKVLDVQKRRIPNKH-- ---YVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKK SGFIQRTTSFLQRGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGW WFVSTSE-EQGWVPATCLEAQDGVQDEL---SMQPDEVPWRYWSLPRHVGRRRTLGDLYT SGWGQ------------EEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQG QEGWAPASYLKKGNGEMFSQKLGSGSSAHSCALDL---DGISRQ--QAVTSREK------ -DGR-------FDNRPLPNADIRRK--------------SPKMRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNA----SRPNFLAPLPS E-----------MAQLRLGDAAA---------------------------ESSATEEATG PCRPLPEAPPNGMDCGM----------------------KRAKDWKGKEAT--------- ESGDLAFTCGYEEISDRD-------VEEKPSLPPR-KESIIKS--EGEL--LERQR---- ----PPPKPPGMILPMIPPKQ-SAAPKDSKKPELKPEKGK-------LFQLKNEMGLECG HKVSAKEVKKPNLRPIVK-P----------------------TKPKAEPVEDKTEPITQN PFLKSRPQIKPKPATAPRTDPPPADD---KLDICSLRSKLR--PA-KCPEKPP------- EQDTAASESSCST---PAVA------P-EASGRFQERPSVESKA---------------- ------------L------------PKSPPGPAVA---------PAAREPT--PQR-PVV PPRRPPPPKKT---------------------TSPV------------------------ ---------------AGPVPEARASPL-----PGRPMLVPPKARPFLSA-A---IQDEAK ----VKS-SVGPKVISKA--VERGEGRERT-----SAPFSNPDVSKEALYVAVADFEG-- DEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_016809693.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan troglodytes] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEEVSWRYWSLPRPVGRRRTLGDLYA ISWRQ------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL---DGVSRQ--QNAVGREKELLSSQ RDGR-------FEGRPVPDGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VTQLRLGEAAAL--------------------------ENNTGSEATG PSRPLPDAPHGVMDSGL----------------------PWSKDWKGSKDVLR------K ASSDMSASAGYEEISDPD-------MEEKPSLPPR-KESIIKS--EGELLERERERQRTE QLRGPTPKPPGMILPMMPAKH-TPPARDSRRPEPKPDKSK-------LFQLKNDMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKTDLPEEKPDATPQN PFLKSRPQVRPKPAPSPKTEPPQGED---QVDICNLRSKLR--PA-KSQDKSLLDGE-G- PQAVGGQDVAFSR---SFLP------G-EGSGRAQDRTG--------------------- --------------KQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAP--QQR-PVV PPRRPPPPKKT---------------------SSSPR----------------------- -----PLPEVRGP--QCEGHESRAAPT-----PGRALLVPPKAKPFLSN-SLG-GQDDTR ----GKG-SLGPWGTGKI-----GENREKAA----AASVPNADGLKDSLYVAVADFEG-- DKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_546237.7 SH3 and PX domain-containing protein 2B isoform X1 [Canis lupus familiaris] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGMQDEF---SLQPEEVSWRYWSLPRPVGRRRTLGDLYA ISWRQ------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKSSGEPLPPKPGTGSPAHTGILDL---DGLSRQ--QSSVGRDRELLNNQ RDGR-------FEGRPVPDGDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLHLP---------------KPPVPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VTQLHLGDAAAM--------------------------ENNTGSEAIG PSRPLPDAPHGAMDSGM----------------------PWSKDWKGGKEVPR------K ASSDMSSCAGYEEISSPD-------LEEKPSLPPR-KESIIKS--EGEL--QERERQRME QLRGSSPKPPGMILPMIPAKH-TPPARDGRRSEPKPDKGK-------LLQLKNEMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKADLPEEKPEGIPQN PFLKSKPQVRPKPAPSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKPLLDGE--- ----GSQDVACSR---SFLP------G-EGPGRTQDRTG--------------------- --------------KQDGLSPKEVPCRAPPKPVKTADPVPKNVPTPLQEAS--PQR-PVV LPRRPPPPKKT---------------------SSSR------------------------ -----PLPEVRGP--QREASEGKAAPA-----PGRALLVPPKAKPFLSN-SSG-GHDDMR ----GKG-GLGPWLVGKI-----GENREKVA----AAPFPSADGSKDSLYVAVANFEG-- DKDTSSFQEGTVFEVREKSSSGWWFCQVLSGAPSWEGWIPSNYLKKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_024837195.1 SH3 and PX domain-containing protein 2B [Bos taurus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLEL---DGVSRQ--QNSVGREKELLNNQ RDGR-------LEGRPVPDGDIRQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VAQLRLGDAAAM--------------------------ENSSGSEASG PSRPLPDAPHSAGDSGT----------------------PWAKDWKGGKEVLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EEEL----QERQRME QFRGSSPKPPGMILPMIPAKH-ALPARDGRKAEPKPEKSK-------LFQLKNETGLECG HRVLAKEVKKPSLRPI--------------------------SKSKAGLPEEKPEAVPQN LFLKSKPQVRPKPAPSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKASVDGE-SS HQAGGGQDGAFSR---GFPP------G-EGPGRAQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPLPE-------VRGPL PEVRGPLPEVRGP--QRESSEGKAAPA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GLGPRMMGKT-----GENKEKVA----AGPFPSTDGPKD-LYVAVANFEG-- DQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_005170345.1 SH3 and PX domain-containing protein 2B isoform X1 [Danio rerio] ----------------------------MP----RRTV---LEVTVQDVQKRRNPNKH-- ---YVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKIL FRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPSGKKK SGIVERASSFLKRGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKNESGW WFVSTED-AQGWVPATCLEAQDD-PDDF---SLPAEE----------------------- -----------------EEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQG KEGWAPASYLKKA--DILSQKMAAGAPVHASTNDL---DVACKQ--QNANKENKE---NQ RD------------RFSPFSDSKR---------------KVGARQRP-PPRRDL------ -----TIPRGVNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGLKVEVIEKNSSGWWYIQIEDKEGWAPVTFIDKYKKTSSA----SRPNFLAPLPG E-----------MEQLKLEDTS----------------------------SNSTNSEHTW -SKPLPDEPSSNSDLST---------------------RSKLREWKPNAAK--------- -SSSHFSGPLPPPPSSPT-------AEEKPALPPR-RESINKS-LELE----DKPKAELS KPLPPKPPVPGVIAPLVTPKA-APLKPDKPPEMKKDDKNK-------QLFLRNEMGLECG HNISVKEVKKFNLKHVAKQPP---------------------TKPKPDLQEDKPESPNPA PFLKPKPVIRPKPAPAAKPE-PVAKN---ELDITNLRSKLR--PS-KPPELNSSDA--NQ QNDTS-----------SSSPP------------NNSRTN--------------------- --------------EEPKCLPKQQNGHGPS----------ETTKPP-KEP---PQR-PSV APRRPPPPKKSS--------------------EPAS------------------------ ------PTDTRAP--QKDLPEAKPAP------PPQSRPPPPKTKAFPLPAPKDKEKEEPK ----PKV-PVPPKPLVKP--DKPGPPRDKL-------PPLIKEPSKEELFLAVADFEG-- DEQTPGFKEGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_017196747.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Oryctolagus cuniculus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLVPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDLASVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SMQSEEVSWRYWSLPRSVGRRRTLGDLNA ISWRP------------EEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKSSGEPLPPKLGLSSAAHPGALDL---DGVSRQ--QNAVGREKELLNNQ RDGR-------FEGRPGPEGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVKVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VAQLRLGDTAAM--------------------------ENSPGGEAVG PSRPLPEAPHGAVDLGM----------------------PWSKDWKGGKDVLR------K ASSDMSASAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL--LERERQRLE QLRGSSPKAPGMILPMVPAKH-ASPARDGRRLEPRPDKSK-------VFQLKNDMGLECG HKVLAKEVKKPNLRPV--------------------------PKSKAEVPDEKPEAAPQN PFLKSRPQVRPKPSPSPRTEPPQGED---QVDICNLRSKLR--PA-KAPEKASLDGE-A- HPAPGGQDAVFSR---NFLS------G-EAPGRVQDRLG--------------------- --------------RQDGLSPKEAACRAPPRPAKNTEPTPKTVPVPLQEA----QR-PAV PPRRPPPPKKTS-------------------GSSSSR----------------------- -----PLPEVRSP--QREAHDSKAAPA-----PGRPLLVPPKAKPFLSN-SPG-GQEDVR ----GPW-G-----AGRV-----GDHREKAI----AASFPNADGPKDSLYVAVANFEG-- DADTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------L------------------ >XP_002816245.4 SH3 and PX domain-containing protein 2B [Pongo abelii] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL---DGVSRQ--QNTVGREKELLSSQ RDGR-------FEGRPVPDGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VTQLRLGEAAAL--------------------------ENNTGSEATG PSRPLPDAPHGAMDSGL----------------------PWSKDWKGSKDVLR------K ASSDMSASAGYEEISDPD-------VEEKPSLPPR-KESIIKS--EGELLERERERQRTE QLRGPTPKPPGMILPMMPAKH-TPPARDSRRPEPKPDKSK-------LFQLKNDMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKTDLPEEKPDATPQN PFLKSRPQVRPKPAPSPKTEPPQGED---QVDICNLRSKLR--PA-KSQDKPLLDGE-G- PQAVGGQDVAFSR---SFLP------G-EGPGRAQDRTG--------------------- --------------KQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAP--QQR-PVV PPRRPPPPKKT---------------------SSSSR----------------------- -----PLPEVRGT--QCEGHESRAAPT-----PGRALLVPPKAKPFFSN-SLG-GQDDTR ----GKG-SLGPRGTGKI-----GENREKAA----AASVPNADGLKDSLYVAVADFEG-- DKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_020932748.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Sus scrofa] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGGQDEF---ALQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPSPPKPGPGSPAHAGVPEL---DGITRQ-----TGREKELLNNQ RDGR-------FDGRPAPDSDMKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VPQLRLGEAAAM--------------------------ENSVSSEATG PSRPLPEAPHGAADSGM----------------------PWSKDWKGGKEVLR------K ASSDMSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL--QERERQRME QLRGASPKPPGMILPMIPAKH-APPGRDSRRPEPKPDKSK-------LFQLKNEMGLECG HKVLAKEVKKPNLRPV--------------------------SKSKADPPEERPEAVPPN PFLKSKPQVRPKPAPSPRTEPAQGED---QVDICNLRSKLR--PA-KSQEKPSVDGE-GG HQAGGGQDMAISR---SFLP------G-EGPGRPQDRTS--------------------- --------------KQDGLSPKEPTCRAPPRPGKTAEPVPKNAPVPLPQAS--QQR-PVV PPRRPPPPKKT---------------------SSSR------------------------ -----PLPEVRGP--QREASEVKAAPA---PGPGRALLVPPKAKPFLST-SPG-GQDDMR ----GKG-GLGPRMTGKX-----GENKDKGA----AAPCPGADGPKDSLYVAVADFEG-- DQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_019475954.2 SH3 and PX domain-containing protein 2B [Meleagris gallopavo] MRDAERSAGSAGRGNGAGFVGSVRAPLSAPG--QRRKAHLSAALRVLNFKHNQEESEK-I GFLMVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKR SGFIQRTTSFLQRGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGW WFVSTSE-EQGWVPATCLEAQDGVQDEL---SMQPDEVPWRYWSLPRHVGRRRTLGDLYT SGWGQ------------EEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQG QEGWAPASYLKKGNGE-FSQKLGSGSSTHSCALDL---DGISRQ--QVVTSREKD---GQ RDGR-------FDNRPLPNADIRRK--------------SPKMRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNA----SRPNFLAPLPS E-----------MAQLRLGDAAA---------------------------ESSATEEATG PCRPLPEAPPNGMDCGT----------------------KWAKDWKGKEAT--------- ESGDLAFTCGYEEISDRD-------VEEKPSLPPR-KESIIKS--EGEL--LERQR---- ----PPPKPPGMILPMIPPKQ-SAAPKDSKKPELKSEKSK-------LFQLKNEMGLECG HKVSAKEVKKPNLRPIVK-P----------------------TKPKAEPVEDKPEPITQN PFLKSRPQIKPKPTAAPRTDPPPADD---KLDICSLRSKLR--PA-KCPEKPP------- EQDTTASESSCSN---PAVA------P-EASGRFQERPSIESKA---------------- ------------L------------PKSPPGPAVP---------LAARELA--PQR-PVV PPRRPPPPKKT---------------------TSPV------------------------ ---------------AGPPPEARASPL-----PGRPMLVPPKARPFLSA-A---IQDEAK ----VKS-SVGPKVISKA--VERGEGRERT-----SAPFSNPDVSKEALYVAVADFEG-- DEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_034816856.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan paniscus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEEVSWRYWSLPRPVGRRRTLGDLYA ISWRQ------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL---DGVSRQ--QNAVGREKELLSSQ RDGR-------FEGRPVPDGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VTQLRLGEAAAL--------------------------ENNTGSEATG PSRPLPDAPHGVMDSGL----------------------PWSKDWKGSKDVLR------K ASSDMSASAGYEEISDPD-------MEEKPSLPPR-KESIIKS--EGELLERERERQRTE QLRGPTPKPPGMILPMMPAKH-TPPARDSRRPEPKPDKSK-------LFQLKNDMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKTDLPEEKPDATPQN PFLKSRPQVRPKPAPSPKTEPPQGED---QVDICNLRSKLR--PA-KSQDKSLLDGE-G- PQAVGGQDVAFSR---SFLP------G-EGSGRAQDRTG--------------------- --------------KQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAP--QQR-PVV PPRRPPPPKKT---------------------SSSSR----------------------- -----PLPEVRGP--QCEGHESRAAPT-----PGRALLVPPKAKPFLSN-SLG-GQDDTR ----GKG-SLGPWGTGKI-----GENREKAA----AASVPSADGLKDSLYVAVADFEG-- DKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_023115375.1 SH3 and PX domain-containing protein 2B [Felis catus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGMQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKSSGEPSPPKLGPGSSAHTGVLDL---DGVSRQ--QSPVGRERELLNNQ RDGR-------FEGRPGPDSDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VTQLRLGDAAAA--------------------------ENNTGSEAVG PSRPLPDAPHGTADSGM----------------------PWSKDWKGGKEVLR------K ASSDMSSCAGYEEISSPD-------LEEKPSLPPR-KESIVKS--EGEL--QERGRQRME QLRGSSPKPPGMILPMIPAKH-TPPSRDSRRPEPKPDKSK-------LFQLKNEMGLECG HKVLAKEVKKPNLRPI--------------------------SRPKAEPPEEKPEVVPQN PFLKSKPQVRPKPTPSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKPLLDGE-SG HQPAGGQDAAFSR---GFLP------G-DGPGRTQDRTA--------------------- --------------KQDGLSPKEMSCRAPPRPAKTADPVPKSVPAPLQEAS--PQR-PVV LPRRPPPPKKT---------------------TSSSR----------------------- -----PLPEVRGP--QREANEGKTAPA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GPGPRMAGKI-----GENREKVA----ATPFPNADGPKDSLYVAVANFEG-- DEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_027835791.2 SH3 and PX domain-containing protein 2B isoform X3 [Ovis aries] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPSPPKLGPGSPAHVGVLEL---DGVSRQ--QNSAGREKELLNNQ RDGR-------IEGRPAPDSDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPS E-----------VAQLRLGDTAAT--------------------------ENSSGSEAGG PSRPLPDAPHGAGDSGT----------------------PWAKDWKGGKEMLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL----QERQRME QFRGSSPKPPGMILPMIPAKH-APPARDSRKAEPKPEKSK-------LFQPKNETGLECG HRVLAKEVKKPSLRPV--------------------------SRSKAGPPEEKPEAVPQN LFLKSKPQVRPKPAPSPRTEPPQGED---PVDICNLRSKLR--PA-KSQEKASVDGE-SS LQAGGGQDGAFSR---GFPP------G-EGPGRAQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPLPE-------VRGPL PEVRGPLPEVRGP--QRESSEGKAAPA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GLGPRMMGKM-----GENKEKVA----AGPFPSTDGPKD-LYVAVANFEG-- DQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_030867156.1 SH3 and PX domain-containing protein 2B isoform X1 [Gorilla gorilla gorilla] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKK S------------GGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEEVSWRYWSLPRPVGRRRTLGDLYA ISWRQ------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDL---DGVSRQ--QNAVGREKELLSSQ RDGR-------FEGRPVPDGDAKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPH E-----------VTQLRLGEAAAL--------------------------ENNTGSEATG PSRPLPDAPHGVMDSGL----------------------PWSKDWKGSKDVLR------K ASSDMSASAGYEEISDPD-------MEEKPSLPPR-KESIIKS--EGELLERERERQRTE QLRGPTPKPPGMILPMMPAKH-TPPARDSRRPEPKPDKSK-------LFQLKNDMGLECG HKVLAKEVKKPNLRPI--------------------------SKSKTDLPEEKPDATPQN PFLKSRPQVRPKPAPSPKTEPPQGED---QVDICNLRSKLR--PA-KSQDKSLLDGE-G- PQAVGGQDVAFSR---SFLP------G-EGPGRAQDRTG--------------------- --------------KQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAP--QQR-PVV PPRRPPPPKKT---------------------SSSSR----------------------- -----PLPEIRGP--QCEGHESRAAPT-----PGRALLVPPKAKPFLSN-SLG-GQDDTR ----GKG-SLGPRGTGKI-----GENREKAA----AASVPNADGLKDSLYVAVADFEG-- DKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_043743513.1 SH3 and PX domain-containing protein 2B [Cervus elaphus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLEL---DGVSRQ--QNSGGREKELLNNQ RDGR-------FEGRPAPDGDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VAQLRLGDAAAM--------------------------ENSSGSEASG PSRPLPDAPHGTGDSGT----------------------PWAKDWKGGKEVLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL----QERQRME QFRGSSPKPPGMILPMIPAKH-APPARDSRKPEPKPDKSK-------LFQLKNEMGLECG HKVLAKEVKKPNLRPI--------------------------SRSKADPPEEKPEAVPQN LFLKSKPQVRPKPAPSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKASVDGE-SS HQAGGGQDGAFGR---GFPP------G-EGPGRPQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPAKTTDPVPKSAPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPLPEVRGPLPDVRGPL PEVRGPLPEVRGP--QRESSESKAASA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GPGPRMMGKS-----GENKEKVA----AGPFPNTDGPKD-LYVAVANFEG-- DQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_043344822.1 SH3 and PX domain-containing protein 2B [Cervus canadensis] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLEL---DGVSRQ--QNSGGREKELLNNQ RDGR-------FEGRPAPDGDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VAQLRLGDAAAM--------------------------ENSSGSEASG PSRPLPDAPHSTGDSGT----------------------PWAKDWKGGKEVLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL----QERQRME QFRGSSPKPPGMILPMIPAKH-APPARDSRKPEPKPDKSK-------LFQLKNEMGLECG HKVLAKEVKKPNLRPI--------------------------SRSKADPPEEKPEAVPQN LFLKSKPQVRPKPAPSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKASVDGE-SS HQAGGGQDGAFGR---GFPP------G-EGPGRPQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPAKTTDPVPKSAPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPLPEVRGPLPDVRGPL PEVRGPLPEVRGP--QRESSESKAASA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GPGPRMMGKS-----GENKEKVA----AGPFPNTDGPKD-LYVAVANFEG-- DQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >KAB0369849.1 hypothetical protein FD755_018842 [Muntiacus reevesi] ML----------------FI-FIYAHAVSP---AHSSL---MESEALPMDSSASNNTQPL GFISVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLEL---DGVSRQ--QNSGGREKELLNNQ RDGR-------FEGRPVPDGDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VAQLRLGDAAAM--------------------------ENSSGSEASG PSRPLPDAPHGTGDSGT----------------------PWAKDWKGGKEVLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL----QERQRME QFRGSSPKPPGMILPMIPAKH-APPARDSRKPEPKPDKSK-------LFQLKNEMGLECG HKVLAKEVKKPNLRPI--------------------------SRSKADPPEEKPEAISQN LFLKSKPQVRPKPASSPRTEPPQGED---QVDICNLRSKLR--PA-KSQEKASVDGE-SS HQAGGGQDGAFSR---GFPP------G-EGPGRPQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPTKTSDPVPKSAPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPLPE-------VRGSL PEVRGPLPEVRGP--QRESSEGKAAPA-----PGRALLVPPKAKPFLSN-SSG-GQDDVR ----GKG-GPGPRMMGKS-----GENKEKVA----AGPFPNTDGPKD-LYVAVANFEG-- DQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_018107654.1 SH3 and PX domain-containing protein 2B isoform X4 [Xenopus laevis] ----------------------------MP---SRRSI---VQVCVQDVQKRRSPNKH-- ---YVYIIKVTWSNGTTEVIYRRYSKFFDLQMQILDKFPVEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARVEDFNPPKEEPFGRKK L------------GGDSSSSDALVLDQYVVAAAYDKQESSEISLQVGQVVDIIEKNESGW WFVSTAD-EQGWVPATCLEAQDGGQDDF---TIQPEE----------------------- -----------------EEKYIVVYPYTARDQDEITLEKGYVVEVIQKNLEGWWKIRYKG SEGWAPASYLKKVSGDLLSQKLAAGSGANSSALDL---DGITRQ--HSFTGQERESPAHL REGR-------IDTRPPHFADIKRK--------------SPVLRQRP-PPRRDL------ -----TIPRGLNLP---------------TPPTPPHVEE----EFYTIADFQTT-IPDG- ISFQAGLKVEVIEKNHSGWWYIQMEDKEGWAPATFIDKYKKTSSA----SRPNFLAPLPN E-----------MAQLCLGDANA---------------------------ENNTEEEATG PCRPLPEPPQNGTDSTS----------------------KWSKDWKGKDPGLKGIQ---I NGRDLGANSVYDEAAG-D-------LEEKPNLPPR-KESMLKT--D-----DASERTSMH QLRVPPSKPPSSLMAPIPQKI-IP-SKETRKPELKNDKNK-------IFQLKNEMGIECG HKVSPKELKKPMLKPVA-------------------------NKPKPEPPTEKPDSIAPN AFLKPKPVVRPKPVTAPKTD-PHNDD---KVDISNLRSRLK--PASKSIDKPN------- DQE-FAGNGASSY---PTST------S-GAAGRPQDRPDL--RP---------------- ------------LQKQDGDGTREPPFKALPVPSRTVDSDLKGGMVSGKEP---PQR-PMI PPRRPPPPKKA---------------------SVSSD----------------------- ------TTEGK----IQKDSELTSSPL-----GNRPIMVPPRARPFNLS-S---SNDDTK ----VKP-SFVPKTQVPR--QMDKEIREKP-----GFSLPTPEVSKETHYVAVADFDG-- DEDTSSFKEGTVFDVQEKSSGGWWFCRVLSGGPAWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_023818605.1 SH3 and PX domain-containing protein 2B isoform X1 [Oryzias latipes] ----------------------------MP----RRTV---QEVTVQDVQKRRTPNKH-- ---YVYIIKVCWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKIL FRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRIFFETRPEDLNPPKEELMVKKK PGFVERATTFLKR-GDSTSGDALLLDQYVAVTDYEKQESSEISLRVGQVVEVIEKNESGW WFVSSED-AQGWVPATCLEVQDD-PDDF---TLPGEEVPRRFWSFPRHVGRRRTLGDLFS TGFGQ------------EEKYSVIYPYSARDQDEIDLERGMIVEVIQKNLEGWWKIRYQG REGWAPASYLKKS--DIQSQRQSAGAAAHASANDL---EGISKQSPQNNA---------- -----------KENRLSLFSDNNKS--------------KVGSRHRP-PPRRDL------ -----TIPRGTNLP---------------KPPVPPLVEE----EFYTIADFQTT-IPDG- ISFQAGVKVEVIEKNGSGWWYIQIEEKEGWAPANFIDKYKKTSNA----LRPNFLAPLPN E-----------MEKLCLEDGGS---------------------------SNVTDTDDTW -SKPLPDEPTTAQDTHT---------------------RPKLRDWKSG------------ -----FSGPLPPAPAAPP-------IEEKPALPPR-RESINKS-FEFEG--VEKPRSDHP KPLPPKPPAPGVIVPLVTPKT-APFKPDKPPEAKKEDKSK-------ALYLKNEMGLECG HKVSAKEVKKFNLKPVPKQP----------------------PKPKSDVQEEKPEVAGPA VLMKAKPVIRPKPAPAAKPE-ALAEK---KVDITNLRSKLR--PS-KPLDQGSAEG--NH QNETVEPGN-------GSSP-------IQIPTLNSDKSS--------------------- --------------DESKITSKHRNALRKD----SSSPPSKPGVPPHKEP---PQR-PTM GPRRPPPPKKA---------------------EQLG------------------------ ------HTETK-PQVMKEPQEIPKNGL-----PQLSRPPPPKPKGFPQP-PASKEKDECK G---NKL-PIPPKPQLKS--EKPGPPKDKL-------PPLLKDSSKEELYLAVADFEG-- DEQTSSFKVGTVFEVLEKNSSGWWFCKNV--GEDSEGWIPSNYLSKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_021152892.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Columba livia] ----------------------------M-------------------AQLPGVPGLS-- ---WVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEXPIGKKR S------------GADSASADPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGW WFVSTSE-EQGWVPATCLEAQDGVQDEF---SMQPDE----------------------- -----------------EEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQG QEGWAPASYLKKGNGEMFSPKLGSGSSAHSCALDL---DGISRQ--QVMVSREKDGLAGQ RDGR-------FDSRPLPNADIRRK--------------SPKMRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------MAQLRLGDATA---------------------------DSSTGEEVTG PCRPLPEAPPNGTDCGG----------------------KWAKDWKGKEAP--------- ESGDLALTSGYEEILDRD-------AEEKPSLPPR-KESIIKS--EGEL--LERQR---- ----PPPKPPGMILPMIPPKQ-SVAPKDSKKPELKPEKGK-------LFQLKNEMGLECG HKVSAKEVKKPNLRPIVK-P----------------------TKPKAEPVEEKPEPIAQN PFLKSRPQIRPKPAAAPRTDPAPADD---KLDICSLRSKLR--PA-KCPEKPS------- EQDTAAGESSLAN---ATVS------S-EASGRFQERPSVESKP---------------- ------------LPKVDSHAMKEVLPKSPLGPANT---------PGARDPP--PQR-PVV PPXXXXXXA--------------------------------------------------- --------ELRAP--AREAPEIRSSPV-----PGRPMLVPPKAKPFLAA-S---IQDEAK ----VKG-SISPKVISKP--VERGEAKERT-----SAPVPSPDISRDALYVAVADFEG-- DEETNSFKEGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_017921047.1 PREDICTED: SH3 and PX domain-containing protein 2B [Capra hircus] ----------------------------MP---PRRSI---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKK S------------GGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGW WFVSTAE-EQGWVPATCLEGQDGVQDEF---SLQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQG KEGWAPASYLRKSSGEPLPSKLGPGSPAHVGVLEL---DGVSRQ--QNSVGREKELLNNQ RDGR-------IEGRPAPDSDIKQR--------------SPKMRQRP-PPRRDM------ -----TIPRGLNLP---------------KPPIPPQVEE----EYYTIAEFQTT-IPDG- ISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------VAQLRLGDAAAT--------------------------ENSSGGEAGG PSRPLPDAPHGAGDSGT----------------------PWAKDWKGGKEMLR------K ASSDTSSCAGYEEISDPD-------LEEKPSLPPR-KESIIKS--EGEL----QERQRME QFRGSSPKPPGVILPMIPAKH-APPARDSRKAEPKPEKSK-------LFQPKNETGLECG HRVLAKEVKKPSLRPV--------------------------SRSKVGPPEEKPEAVPQN LFLKSKPQVRPKPAPSPRTEPPQGED---PVDICNLRSKLR--PA-KSQEKASVDGE-SS LQAGGGQDGAFSR---GFPP------G-EGPGRAQDRTS--------------------- --------------KQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEAS--LQR-PVV PPRRPPPPKKT---------------------SSSSRPLPEVRGPPPE-------VRGPL PEVRGPLPEVRGP--QRESSEGKAAPA-----PGRALLVPPKAKPFLSN-SSG-GQDDMR ----GKG-GLGPRMMGKT-----GENKEKVA----AGSFPSTDGPKD-LYVAVANFEG-- DQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_014374200.1 SH3 and PX domain-containing protein 2B [Alligator sinensis] ----------------------------MP-------------LLKADEEMLRIP----- ---WVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKK SGFIQRTASYLQRGGDFASVD-LVLEQYVVVADYQKQESSEISLCVGQTVDIIEKNESGW WFVSTSD-EQGWVPATCLEAQDGVQDEF---SMQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQG QEGWAPASYLKKGSGEMFTQKLGSGSSTHSSALDL---DGISRQ--QNSAGREKDGPNNQ RDVR-------FDGRLQPNADIRRK--------------SPKMRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGMKVEVIEKNLSGWWYIQIDEKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------MVQLRLGDVTV---------------------------EDSASEEATG PCRPLPEAPPNGMDCGT----------------------KWAKDWKGKDSL--------- ESGDLAVASGYEEIPDQD-------IEEKPSLPPR-KESIIKS--EGEF--MERQR---- ----PPPKPPGMILPMIPPKQ-TPAPRDSKKPELKTEKGK-------LFQLKNEMGLECG HKVSAKEVKKPNLRPIIK-P----------------------AKPKAEPLEDKPEPTTQN PFLKSRPQVRPKPAPAPRTDLPPVDD---KLDICSLRSKLK--PA-KCQERSS------- EQDPGASENSFSN---NALP------A-DAPGWPQEQPSAENRP---------------- ------------LPKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPP--PQR-PVV PPRRPPPPKKA---------------------TPCSS----------------------- ----GSTSDLKAP--QREVPDLRAASV-----PGRPMLVPPKAKPFLPA-L---GQDEAK ----VKS-NLGPKVTPRQ--VERGEAKERT-----AAPFPNPDISKEALYVAVADFEG-- DEETNSFKEGTLFEVREKNSSGWGFCKVLTGGACWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_014453036.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Alligator mississippiensis] ----------------------------MP----RRSL---VEVKVLDVQKRRVPNKH-- ---YVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKK SGFIQRTASYLQRGGDFASVD-LVLEQYVVVADYQKQESSEISLCVGQMVDIIEKNESGW WFVSTSD-EQGWVPATCLEAQDGVQDEF---SMQPEE----------------------- -----------------EEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQG QEGWAPASYLKKGSGEMFTQKLGSGSSTHSSALDL---DGISRQ--QNSAGREKDGPNNQ RDVR-------FDGRLQPNADIRRK--------------SPKMRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGMKVEVIEKNLSGWWYIQIDEKEGWAPATFIDKYKKTSNA----SRPNFLAPLPN E-----------MVQLRLGDVTV---------------------------EDSASEEATG PCRPLPEAPPNGMDCGT----------------------KWAKDWKGKDSL--------- ESGDLAVASGYEEIPDQD-------IEEKPSLPPR-KESIIKS--EGEF--MERQR---- ----PPPKPPGMILPMIPPKQ-TPAPRDSKKPELKTEKGK-------LFQLKNEMGLECG HKVSAKEVKKPNLRPIIK-P----------------------AKPKAEPLEDKPEPTTQN PFLKSRPQVRPKPAPAPRTDLPPVDD---KLDICSLRSKLR--PA-KCQERSS------- EQDPGASENSFSN---NALP------A-DAPGWPQEQPSAENRP---------------- ------------LPKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPP--PQR-PVV PPRRPPPPKKA---------------------TPCSS----------------------- ----GSTSDLKAP--QREVPDLRAAPV-----PGRPMLVPPKAKPFLPA-L---GQDEAK ----VKS-NLGPKVTPRQ--VERGEAKERT-----AAPFPNPDISKEALYVAVADFEG-- DEETNSFKEGTLFEVREKNSSGWWFCKVLTGGSCWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_015816888.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Nothobranchius furzeri] ----------------------------MP----RRTA---QEVIVQDVQKRRIPSKH-- ---YVYIIKVSWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKIL FRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKR AGFVERTTTYLKRAGDSNSADPLLLEQYVAVTDYEKQESTEISLHVGQVVEVIEKNESGW WFVSSED-AQGWVPATCLEAQDD-PDDF---TLPGEEVPRRFWSLPRHVGRRRTLGDLFS TGFGQGGAHAFLFPTILKEKYSVIYPYSARDQDEIDLEKGMIVEVIQKNLEGWWKIRYQG REGWAPASYLKKA--DIQSQRQSAGAAAHASTNDL---EAFSKQNQQNNAARE-----NR DN-Q-------KENRLSFFSDNK----------------KVGLRHRP-PPRRDL------ -----TIPRGTNLP---------------KPPVPPQVEE----EYYTIADFQTT-IPDG- ISFQAGVKVEVIEKNASGWWYIQIDDTEGWAPATFVDKYKKTSNA----LRPNFLAPLPN E-----------MEKLRQEDGGS---------------------------SNVSGKDDTW -SKPLPDEPTTGSESCA---------------------RPKLRDWKSNPSK--------- -GTSAFSGPLPPAPAAPP-------AEEKPALPPR-RESINKS-FELEV--AEKAKSDHS KPLPPKPPAPGVIMPHVAPKM-PPFKPEKPTEVKKDDKNK-------ALYLRNEMGLECG HKVSAKEVKKFNLKPVPKQP----------------------PKPKPEIQEEKPEAAGPA SFIKAKPVIRPKPAPAAKPE-GQADD--SKLDITNLRSKLR--PS-KPADLGSASAEVNH QNDTSATGNGFHPSSPPSSP------SVHIPSVNNGKCS--------------------- ---------------EPKLPTKHTNGLSQE----RSSPSAKPAVPPHKEL---PQRPPTM APRRPPPPKKT---------------------DPSS------------------------ ------PTEPKSPPTLKEPQEVPRPGP-----PQLSRPPPPKPKGFVHP-PVSKENNEPR V---NKV-PIPPKPQLKS--EKPGPPKDKL-------PPLLKDSSKDELYLAVADFEG-- DEQTSSFKVGTVFEVLEKNSNGWWFCKNV--GEEVEGWIPSNYLSKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_030294651.1 SH3 and PX domain-containing protein 2B isoform X1 [Sparus aurata] ----------------------------MP----RRTV---HEVTVQDVQKRRNPNKH-- ---YVYIIKVSWSDGSTEVIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKIL FRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKK SGIVERATTFLKR-GDSSAGDPLLLDQYVAVTDYEKQESSEVSLHVGQVVEVIEKNESGW WFVSSED-AQGWVPATCLEAQDD-PDDF---TFPGEEVPRRFWSLPRHMGRRRTLGDLFS TGFGQ------------EEKYSVIYPYSARDEDEIDLERGMIVEVIQKNLEGWWKIRYQG REGWAPASYLKKS--DIQSQKQSAGGAVHASTNDL---D--SKQNQQNNAAKE-----NR DNGH-------KENRLSFFSDK-----------------KVGSRHRP-PPRRDL------ -----TIPRGANLP---------------KPPIPPQVEE----EFYTIADFQTT-IPDG- ISFQAGIKVEVIEKNASGWWYIQIDDKEGWAPATFIDKYKKTSNA----LRPNFLAPLPN E-----------MEKLSLADGVS---------------------------SNASGTDDSW -SKPLPDEPPTAPESCA---------------------RPKLRDWKSGPSK--------- -GG---CGPLPPAPAAPP-------VEDKPALPPR-RESINKS-FEVEV--AEKPRPDHS KPLPPKPPAPGVIMPMVPPKAPPPLKQDKPPETKKEDKSK-------PLLLRNEMGLECG HKVSAKEVKKFNLKPVPKHP----------------------PKPKSEAPEEKPEAAGPA VFMKAKPVLRPKPPPAAKPD-PPSEN---KLDITNLRSKLR--PP-KPADL--------- --ETPAAGNNPQPS--PSSP-------VHIPSLNNGKHC--------------------- --------------DEPKLPPKHINGHSQE----SSSPPAKPAVPPHKEP---PQRPPAM APRRPPPPKKE---------------------TPSS------------------------ ------PTELKPPPAPKEIQDVPKIPP-----PQLNRPPPPKPKGFVAP-PPNKEKEEPK V---NKV-PIPPKPMLKS--EKPGPPKDKL-------PPLLKEPSKDELYLAVADFEG-- DDNTSSFKVGTVFEVLEKNGSGWWFCKNV--REEVEGWIPSNYLSKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_040200471.1 SH3 and PX domain-containing protein 2B isoform X1 [Rana temporaria] ----------------------------MS----RKSI---VQVNVQDVQKRRSPNKH-- ---YVYIISVSWSNSSSEVVYRRYSKFFDLQMQLLDKFPVEGGQKDPKQRIIPFLPGKIL FRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARLEDFNTPKEEHIGRRK F------------GADSASADPLVFDQYVVVAPYDEQESSEISLQVGQVVDIIEKNESGW WFVSTAD-EQGWVPATCLEAQDGGQDDF---TIQPEEAPWRYWSLPRHVGRRRTLGDLYT SGWGP------------DEKYSVIYPYIARDQDEITLDKGVIVEVIQKNLEGWWKIRYKG AEGWAPASYLKKISGDLLAQKLASGSSANSSALDL---DGLSRQ--QNFTSRDRDVP--- -------------GRQAHVTDFKRK--------------SPILRQRP-PPRRDL------ -----TIPRGLNLP---------------KPPTPPHVEE----EYYTIADFQTT-IPDG- ISFQAGLKVEVVEKNHSGWWYIQIDDKEGWAPATFIDKYKKTSNA----LRPNFLAPLPN E-----------MAQLCLSNAST---------------------------ENTSVEEASG PCRPLPEPPQNGTDPVS----------------------KWSKELKNKDPGFKSSP---L DGKEHFSNSVYDEAAVDD-------GEEKPSLPPR-RESMLKT--E-----EVSERPSMP QHRAPPPKPLTSMMASSPQKQ-LP-SKEVKKPEIKNDKSK-------MFQLKNEMGLECG HKVSPKELKKPMLKPVA-------------------------NKPKPEISSEKPELMVPN PFLKAKPQVKPKPVATTKTE-GSSED---KVDISNLRSRLK--PSGKSLDKGN------- EQEPCASSGVSDT---KVYN------CIGAAGRPFDKPDQ--KH---------------- ------------LYKQNNSIPGEPPSKALPVPLRTVDTEPK----AARDL---PQR-PVI PPRRPPPPKKV---------------------SMSCE----------------------- ------TNEGRAT-QIKESSDFTVAHM-----ANRPIMVPPKSKPLISL-P---GSDDTK ----VKN-SFVPKMPASR-LADKSETKEKP-----VSSTP------PSQYVAVADFDG-- DEDTSSFKEGTIFEVQEKSSNGWWFCRVLSGGPTWEGWIPSNYLRKK------------- ------------------------------------------------------------ ------------------P------------------ >XP_038045303.1 SH3 and PX domain-containing protein 2A-like isoform X4 [Patiria miniata] ----------------------------MG----RRTV---QDAIVDDIQKRKYPTKH-- ---YEYVIHVSWSDGSVNVVYRRYSKFFDFQMKLLSIFPEEAGARNPTQRMIPFLPGKKL FGRSQTREVASRRLGQLNEYCQLLVRLPPKISESDEVLQFFTPTAEDINPVTERGVIKKG A------------KEIDVISDPIQPDPYIVIADYKKQQKNEVDLHTGDNVEVFEKNDNGW WFVSSND-SQGWAPATFLSRADGGDDED--GLAGGGT----------------------- -----------------EERYISNNSYKAQQEDEVSFETGVVLIVMQKSLDGWWKVRYKE KIGWVPAAFLQVYTG---PADVTASTPTQRVGNVMSVSDIISRR--QAAD---------- ------------SSKNSPMLGRKDN-----------LH-SHGTEAKPTPPRRTTVRPGQK TDDERTVRKGATRK---------------RRPTATKKTL----EYYTVADFSDS-AGDS- ISFKSGQKVQIIQETESGWWLVKIGDEEGWAPSSYMEAKEETVAE----TRPQ-----PS N-----------RESL----------------------------------DEETGESSP- -RPPRPPPPTGRKISNG----------------------GATSSSSGTGGFRP-V----- ------------------------------STPG-------------------------- ------GSKSSGAASAFRPVS-MPSS---------------------------------- ----------NNGRPL----------------------------------PVTPAFKPAP PALKPTPQTQPKPFRPSSGG---GSN-----LIQNAQANLK--PV-RSQSKPPLVNR--- ------------------------------------------------------------ -----------------------------------------------------QKK-PGA QPNGSPIGT--------------------------------------------------- ------------------------------------------------------------ -----------PGSNVQP--SQIADLQNQLKSLKTPSSGGVRDRRPSNAYVTTAAYENVD DDDGLSFEEGVQVEVIEENDTGWWLVRI----AGEEGWAPSTYLEKA------------- ------------------------------------------------------------ ------------------------------------- >XP_030842214.1 SH3 and PX domain-containing protein 2A isoform X3 [Strongylocentrotus purpuratus] ----------------------------MG----KRTV---VNANVTDIEKRREPTKH-- ---YVYIIHVTWSDGSVNVVYRRYSTFFDFQNKLLSKFPEEAGANNPSSRCIPFLPGKKL FGRSHIREVALKRLSPIDEYCTALVKLPGKISDSKEVINFFTPTPEDVSPPSPDGGGEST RG----------RADIGNISEPIQAEQYIVVADYKKQQKNEVELTAGDLVEVFEKNDNGW WFVTVHD-QHGWAPGTFLQNPDGQEEED-EETLIPGN----------------------- -----------------DESYITNNAYQGQAEDEISFETGVVVTVIQKSLDGWWKVSYQG KQGWAPATFLQIYKG---PSGVTPKHPTQSIGNVMLL--------KSGSDSKPKP---GP GPGS--------SGRPQPPVQPRDE--------PGQLYSNYDAEVKPTPPRRATVK---- ----KSVRRGGVRQT--------------KPKLKKVM------EHYTTDSFQGA-AGEGS ISFESGQKVEVLEENDGGWWYVKMNGQEGWAPSNYIEKREVSSRI----NGKPSLGNL-- --------------------------------------------------DEETGEDKV- -PPVLPARPAF--------------------------------GSGGSGAFKP------- --------------------------VAKKSTPP-------------------------- ------PVDRSNSPSFTNRKA-VT------------------------------------ ----------NNGRGG-------------------------------------------- ----------GDGVRRGSGGVGAGGN-----MMAALKKQLEKSSV-GESSSPAI------ ------------------------------------------------------------ -----------------------------------------------------PAR-PGV APKLSKPTAQ-------------------------------------------------- ------------------------------------------------------------ -----------PYC------------------------------NRDAAYITTSSYVN-D ENDGLSFKEGQRVEVIKKDDSGWWSVRI----GNTEGWVPNTFLEKI------------- ------------------------------------------------------------ ------------------------------------- >XP_031561245.1 SH3 and PX domain-containing protein 2A-like [Actinia tenebrosa] ----------------------------MV----KRTL---TSVKIVDIQKRKVPSKH-- ---YVYVISVTWSDGSVNVVYRRYSKFFDLQTKLLEEFPVEGGVQNPSTRVIPFLPGKII FGRSHVRDVALKRKESIDEYCSKLIELDPKLSQSDLVLKFFEPSSDDIDIPAEKK--KKK N------------ETADNISDPISLDQYVAIADYQKQNRNEISMAAEDVVEVIDKNENGW WFVNLDE-EQGWVPAAYLEPLDGPSDDMDFTDVSSVE----------------------- -----------------ENQFITTTSHIAELDDEISFEMGVIVTVVKKNFDGWWLIRYQN KEGWAPAMYLKKPDP---MQLHAAEIG-----------GAVPKRDSVPVITHAPIM---Q QPTS-----------------------------------NLARKGKGVPPRKAS------ ------VKRSIRKPFSIANQSYEKHFEPVKETAAIHSEA----EYVTIGDFRAVDIQSG- LSFDKGEAVEILDKSPNGWWLGKIGGHEGWIPSSYVEKRNRSQKG-------NVVTPKPD R-------PQLPSSRLSISEIKP----------ETSQSPDLKSDLNIALSSMRLKSCAA- -SEPAEPSGQSSTKEMY----------------------AAVSDFEDSSDGVVCL----- --KEGDVVEVVDKSEGEWWLVR---LNEKQGWVP--SSYLTKQ--------EIKNSPAPR RPK-PPASKPSSSSQGASKPA-LPAIP-SSKPVSSQKMNKKPLLPSVPSGKPGTLRKTDG KPLPS---PVLSGKPA--------------------------TLQKTNGKPTPPPVPSAK PTLAQKPKAKPSPHPVPKGK-----------------------PA--------------- ------------------------------------------------------------ ----------------------------------------------------FPQK-TTA KPVPPPVPSTKP--------------------SVSQKP--------------M------- ----ALPVSSRNP-QRDSLQNQQHKPVFPLKPVKQNSPVSNKKDDNINR-PKKIGKLNTA LFE-SKIPIFAPQLDETP--KQAETPSKKIPPTTEKPTRNEPAKPSASQCVAIAAFTN-T DQDGLSFSEGDLFDFLEDSGSGWWLVKTQA--TNREGWAPSSYLEMKTPDN--------I TPIANQTNRPQRRDPPDPPKRPDSSKPAKQFYVAIATFCEDDETSVSFQEGDTIEVLQQD DGGWW--MVKVNDETGWAP----------SNYLQPL- >CAE1310922.1 SH3PXD2 [Sepia pharaonis] ----------------------------M-----RKSV---TAVEVVDVEKRRLPSKH-- ---YVYVIQVTWDDGSSITIYRRYSNFFDLQTSLLETFPEEGGQLNPDERTIPFLPGKKY FGRSHIREVAEKRLGPIDKYCKLLIKLDKKISQCHEVLTFFEPTADDLSPKSQEK----- ------------KPGEAKISKPKVLEQYEAIFDYQKQAKDQVDLKVGQSVQVIEKYETGW WLVNTEY-EEGYAPGTFLQKTDGQEEEQ----MFTCN----------------------- -----------------GEKYICIQSYTAEVPDDHTLNIGAEVEVLQKSLDGWWWVRYKG KIGWAPATCLKVADS---ISRHSANIPVEIVSNL----SDVSKLLKGNDTTADSPMTVSQ RPKSAAETYTYFSSASVQDSDNYEEVEESHYSHINSIYGNTSHTVVP-PPRQKS------ -----IRDKG---------------------KVPMNAEE-NKTKFITCAEYIDS-VGDG- ISFSAGQEVEVQQKTDSGWYYIKLGNEFGWAPSSYLEEIPLDETH--SSVRFDKIQEEKA EEDDDDDDDDDEYETINLCPAKQIENI-LVSKLTPAHSPSNSQIDGLE--RNSSSSDEL- -KLPLSSSPTGSSSSACPSTNSSLSRTAVKRPNSIPPAPPKRPDHPGGQPPLPSV--PPV SSATKINPQLPPPPPPPS-------SVPKKPVPPS-STGLYKS-----------SKTSAT CPPQPPPPPPGRPYSGISHPLVTNSVADHSKETSNTSGNL-------ATELQSRLAKLKA NFDSGSSANTKKQQPLTKEKPVIIHGVNIKGGATSVAGNNSKVTKTKDIKKSQPQVFLPH -VQKTTPILPASPSNVDNSPSQAEKDDIQRIPVPNVSDSSVVVPSSKFAEKLSVFQM-NT NGDNAAATPKFSS---PNVPLASNCRGLALLQRQKDKLMEEAESNCKASNESLEHEAKVS NLRNNFESSTCKLSTSSSVPPDQSTNVKPAPPTKPIHK-VKPTTVPAKANPNLPVK-PKV SPCKPKFGAVTN---------------TGKKDSTTNIA---------------------- ----NKINKFGGN-NMASPAKISAAEM-----------EPPKFQLVKEK----------- --------VMTPTNQTQQ--NTAKEMRTSNTDFNINSVIQRAPKSTDRSYKASSRYIA-E SEGEVSFEKGVDIEVLEKHESGWWLVHI----GDEEGWAPSNHIAEL------------- --------------KPLPPTKP--LPPNK----PLPKLPSSPSTKSTGQTAKPVISINTT S-----PNLSFNCRDHRRPFPFVLFFFLHQKYL---- >XP_039260717.1 SH3 and PX domain-containing protein 2A-like isoform X2 [Styela clava] ----------------------------MPGTVGRRTL---VKVEVGDAEKRRIPSKH-- ---YSYVIKVWWDDDSETVVYRRYSKFFEFQIILLETFPYEGGLKEPSARIIPFLPGKIL FRRSHVRDVAMKRLKPIDEYCKALIKLPSHISKCNHVLDFFETRQEDLNPSREEGSRRRK RD----------DQEIGEISGPLLLEQYVAIADYNSTQQKELTMTIGQKVEVIEKNENGW WFVSNDEGERGWVPGVYLEKPDGTVEDLVTNRAEPGQ----------------------- -----------------GEHYVTTNAYVAENSDDISFGAGVIVEVLQKNLEGWWLVSYNG RQGNAPASYLEKS-----HNWVPENNKVEIISSI----HDLKHRHSLPANSLSSIAFPSQ RIVN------FSSSNSKPIPAEVHSIPEEPKSPVSPSY-FREKTVQP-PPKKSS------ -----VKRTNKRRPM-------------APPPLPPSAAAEPTYEYTTVASFDSN-IPDG- ISFKDDKKVEVLEKSPGGWWYVNIDGSEGWAPASYIEKKETKPKTIVPPSRPGPPKLLKN N----------STNSFSITAAGRSSPVHKVQSSDTVNHPVLGKVASIPILRNQSSMSPA- -KRPLPPLPTSVSSSNV----------------------QDCSDTYEEVATRP-LSENIK FGASKSIPPAVPKSTAKPNLNKTAIESQKVETTPVDFRSVLKSSLAKKN--EIKTRSAQS PPR--PSTNPSPLSNVMKPKI-QPNNI-NLRPKTTTSTQK-------PSNVRNSVTRMNS NETSS---AVNNLKPVF-------------------------GGKTAEGPPRLPP----- ---KPKPGLNSVKAKPVQGNVPTNDD-----AITDFRSVLR--ST-QRKQSASTNGV--- --------------------------G-RSKSFNSDKVI--------------------- -------------------------------STKKVEQGNKPPFV--------PKK-PAN MPLKPPVPTKMKELDEFSGGEENNPKAPGKRNTTTTRP-PWNSG---------------- PGTKPVIRRFQTN-NNSNVDEVQKKPVFTVGHLKIELKNPPDLTKSLPKRGSPDGQVDCK FEDTSKSNTITPPTRTKKILKSKHNPKNSKSVSKTNLQKTESNDSSSNFCIAMSDYTG-I EECEISFQSGDRAELLEKGDNDWWYIKM----GENVGWAPSTYFKLTCEEESSEKDYVAV DGSSNAKSDQESFYNKIEPERP--SFPSK--FVAVADFEADNHSMVSLHAGDEVTITQEA SGGWWYAILSNGNGEGWVP----------SSYLDPVE
BMGE Cleaned alignment of selected proteins >sp|A1X283|SPD2B_HUMAN SH3 and PX domain-containing protein 2B OS=Homo sapiens OX=9606 GN=SH3PXD2B PE=1 SV=3 PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKKASSDMSAGYEEISDPDMEEKPSLPPRKESIIKSRERERQRTEQLRGPTPKPPGVILPMMPAKHIPPARDSRRPEPKPDKSRLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRKSQDKSLLDGEPQAVGGQDVAFSREGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPPVVPPRRPPPPKKTSSSSRPLPEVRGPCEGHESRAAPTPGRALLVPPKAKPFLSNGQDDTRSLGPWGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >NP_796338.2 SH3 and PX domain-containing protein 2B [Mus musculus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKKASSDLSTGYEEISDPTQEEKPSLPPRKESIIKSLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSK-FPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRKSQEKALLDGEHHAAGSHDTALSREGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATPVVPPRRPPPPKKTSSSPLPLPEVRGARE--ESRVAPAAGRALLVPPKAKPFLSNGQDDMRGLGPRGETREK--AASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_017453105.1 SH3 and PX domain-containing protein 2B isoform X1 [Rattus norvegicus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPVEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGSDPTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGVVVEVIQKNLEGWWKIRFQGKEGWAPASYLKKSSGEPLPPKLGPSSSAHSGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRLAPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGEAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKKASSDLSTGYEEISDPTQEEKPSLPPRKESIIKSLERERQKMEPHRGSSPKPPGVILPMIPAKHAPLARDSKKPEPKPDKSK-FPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELPEEKVEPPQNLFLKSRPQVRPKPTPSPKTEPAQGEDQVDIYNLRSKLRKSQEKALLDGEHHAAGGHDTALGREGPGRGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATPVVPPRRPPPPKKTSSSPLPLPEVRGSRE--ESRAIPASGRALLVPPKAKPFLSNGQDDIRGLGPRGETREK--AASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCRVLSGAPSWEGWIPSNYLRKK >XP_025010804.2 SH3 and PX domain-containing protein 2B isoform X1 [Gallus gallus] -RRSIAEVKVLDVQKRRIPNKHYVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKKSGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDELSMQPDEEEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGEMFSQKLGSGSSAHSCALDLDGISRQQAVTSREK-------DGRFDNRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASRPNFLAPLPSEMAQLRLGDAAA-ESSATEEATGPCRPLPEAPPNGMDCGMKRAKDWKGKE-ESGDLACGYEEISDRDVEEKPSLPPRKESIIKSLERQR--------PPPKPPGMILPMIPPKQSAAPKDSKKPELKPEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPITKPKAEPVEDKTEPTQNPFLKSRPQIKPKPATAPRTDPPPADDKLDICSLRSKLRKCPEKPP----EQDTAASESSCSTEASGRFQERPS-----------PKSPPGPAVA---------PAAREPTPVVPPRRPPPPKKTTSPV---------GPVPEARASPLPGRPMLVPPKARPFLSAIQDEAKSVGPKGEGRERT-SAPFSNPDVSKEALYVAVADFEGDEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK >XP_016809693.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan troglodytes] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKKASSDMSAGYEEISDPDMEEKPSLPPRKESIIKSRERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRKSQDKSLLDGEPQAVGGQDVAFSREGSGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPPVVPPRRPPPPKKTSSSPRPLPEVRGPCEGHESRAAPTPGRALLVPPKAKPFLSNGQDDTRSLGPWGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_546237.7 SH3 and PX domain-containing protein 2B isoform X1 [Canis lupus familiaris] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGMQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKSSGEPLPPKPGTGSPAHTGILDLDGLSRQQSSVGRDRELLNNQRDGRFEGRPVPDGDIKQRSPKMRQRPPPRRDMTIPRGLHLPKPPVPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVTQLHLGDAAAMENNTGSEAIGPSRPLPDAPHGAMDSGMPWSKDWKGGKKASSDMSAGYEEISSPDLEEKPSLPPRKESIIKSQERERQRMEQLRGSSPKPPGMILPMIPAKHTPPARDGRRSEPKPDKGKLLQLKNEMGLECGHKVLAKEVKKPNLRPISKSKADLPEEKPEGPQNPFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRKSQEKPLLDGE----GSQDVACSREGPGRTQDRTGKQDGLSPKEVPCRAPPKPVKTADPVPKNVPTPLQEASPVVLPRRPPPPKKTSSSR-PLPEVRGPREASEGKAAPAPGRALLVPPKAKPFLSNGHDDMRGLGPWGENREKVAAAPFPSADGSKDSLYVAVANFEGDKDTSSFQEGTVFEVREKSSSGWWFCQVLSGAPSWEGWIPSNYLKKK >XP_024837195.1 SH3 and PX domain-containing protein 2B [Bos taurus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLAPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRLEGRPVPDGDIRQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSAGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGMILPMIPAKHALPARDGRKAEPKPEKSKLFQLKNETGLECGHRVLAKEVKKPSLRPISKSKAGLPEEKPEAPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRKSQEKASVDGEHQAGGGQDGAFSREGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKATPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSEGKAAPAPGRALLVPPKAKPFLSNGQDDMRGLGPRGENKEKVAAGPFPSTDGPKD-LYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_005170345.1 SH3 and PX domain-containing protein 2B isoform X1 [Danio rerio] -RRTVLEVTVQDVQKRRNPNKHYVYIIKVAWSDGSTEVIFRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLKPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPSGKKKSGGDSSSADPLLLDQYVAVTDYEKQESSEISLYVGQVVEVIEKNESGWWFVSTEDAQGWVPATCLEAQDD-PDDFSLPAEEEEKYTAIYPYSARDQDEIDLERGMTVEVIQKNLEGWWKIRYQGKEGWAPASYLKKA--DILSQKMAAGAPVHASTNDLDVACKQQNANKENKE---NQRD-----RFSPFSDSKR-KVGARQRPPPRRDLTIPRGVNLPKPPVPPQVEEEYYTIADFQTTISFQAGLKVEVIEKNSSGWWYIQIEDKEGWAPVTFIDKYKKTSSASRPNFLAPLPGEMEQLKLEDTS--SNSTNSEHTW-SKPLPDEPSSNSDLSTSKLREWKPNA--SSSHFPLPPPPSSPTAEEKPALPPRRESINKS-DKPKAELSKPLPPKPPVPGVIAPLVTPKAAPLKPDKPPEMKKDDKNKQLFLRNEMGLECGHNISVKEVKKFNLKHVTKPKPDLQEDKPESNPAPFLKPKPVIRPKPAPAAKPE-PVAKNELDITNLRSKLRKPPELNSSDA-QNDTS-------------NNSRTNEEPKCLPKQQNGHGPS----------ETTKPP-KEP-PSVAPRRPPPPKKSEPAS--PTDTRAPKDLPEAKPAP-PPQSRPPPPKTKAFPLPEKEEPKPVPPKGPPRDKL---PPLIKEPSKEELFLAVADFEGDEQTPGFKEGAVFEVMERNTSGWWFCKNVSDGPVMEGWIPSNYLTKK >XP_017196747.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Oryctolagus cuniculus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLVPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDLASVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSMQSEEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKSSGEPLPPKLGLSSAAHPGALDLDGVSRQQNAVGREKELLNNQRDGRFEGRPGPEGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVKVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVAQLRLGDTAAMENSPGGEAVGPSRPLPEAPHGAVDLGMPWSKDWKGGKKASSDMSAGYEEISDPDLEEKPSLPPRKESIIKSLERERQRLEQLRGSSPKAPGMILPMVPAKHASPARDGRRLEPRPDKSKVFQLKNDMGLECGHKVLAKEVKKPNLRPVPKSKAEVPDEKPEAPQNPFLKSRPQVRPKPSPSPRTEPPQGEDQVDICNLRSKLRKAPEKASLDGEHPAPGGQDAVFSREAPGRVQDRLGRQDGLSPKEAACRAPPRPAKNTEPTPKTVPVPLQEA-PAVPPRRPPPPKKTSSSSRPLPEVRSPREAHDSKAAPAPGRPLLVPPKAKPFLSNGQEDVRG----GDHREKAIAASFPNADGPKDSLYVAVANFEGDADTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_002816245.4 SH3 and PX domain-containing protein 2B [Pongo abelii] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNTVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGAMDSGLPWSKDWKGSKKASSDMSAGYEEISDPDVEEKPSLPPRKESIIKSRERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRKSQDKPLLDGEPQAVGGQDVAFSREGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPPVVPPRRPPPPKKTSSSSRPLPEVRGTCEGHESRAAPTPGRALLVPPKAKPFFSNGQDDTRSLGPRGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_020932748.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Sus scrofa] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGGQDEFALQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPSPPKPGPGSPAHAGVPELDGITRQ---TGREKELLNNQRDGRFDGRPAPDSDMKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVPQLRLGEAAAMENSVSSEATGPSRPLPEAPHGAADSGMPWSKDWKGGKKASSDMSAGYEEISDPDLEEKPSLPPRKESIIKSQERERQRMEQLRGASPKPPGMILPMIPAKHAPPGRDSRRPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPVSKSKADPPEERPEAPPNPFLKSKPQVRPKPAPSPRTEPAQGEDQVDICNLRSKLRKSQEKPSVDGEHQAGGGQDMAISREGPGRPQDRTSKQDGLSPKEPTCRAPPRPGKTAEPVPKNAPVPLPQASPVVPPRRPPPPKKTSSSR-PLPEVRGPREASEVKAAPAPGRALLVPPKAKPFLSTGQDDMRGLGPRGENKDKGAAAPCPGADGPKDSLYVAVADFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_019475954.2 SH3 and PX domain-containing protein 2B [Meleagris gallopavo] QRRKAAALRVLNFKHNQEESEKMVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEEPIGKKRSGADSASVDPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDELSMQPDEEEKYTVIYPYTARDQDEMNLDKGAVVVVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGE-FSQKLGSGSSTHSCALDLDGISRQQVVTSREKD---GQRDGRFDNRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASRPNFLAPLPSEMAQLRLGDAAA-ESSATEEATGPCRPLPEAPPNGMDCGTKWAKDWKGKE-ESGDLACGYEEISDRDVEEKPSLPPRKESIIKSLERQR--------PPPKPPGMILPMIPPKQSAAPKDSKKPELKSEKSKLFQLKNEMGLECGHKVSAKEVKKPNLRPITKPKAEPVEDKPEPTQNPFLKSRPQIKPKPTAAPRTDPPPADDKLDICSLRSKLRKCPEKPP----EQDTTASESSCSNEASGRFQERPS-----------PKSPPGPAVP---------LAARELAPVVPPRRPPPPKKTTSPV---------GPPPEARASPLPGRPMLVPPKARPFLSAIQDEAKSVGPKGEGRERT-SAPFSNPDVSKEALYVAVADFEGDEETNSFREGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK >XP_034816856.1 SH3 and PX domain-containing protein 2B isoform X1 [Pan paniscus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKKASSDMSAGYEEISDPDMEEKPSLPPRKESIIKSRERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRKSQDKSLLDGEPQAVGGQDVAFSREGSGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPPVVPPRRPPPPKKTSSSSRPLPEVRGPCEGHESRAAPTPGRALLVPPKAKPFLSNGQDDTRSLGPWGENREKAAAASVPSADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_023115375.1 SH3 and PX domain-containing protein 2B [Felis catus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGMQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKSSGEPSPPKLGPGSSAHTGVLDLDGVSRQQSPVGRERELLNNQRDGRFEGRPGPDSDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPVPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVTQLRLGDAAAAENNTGSEAVGPSRPLPDAPHGTADSGMPWSKDWKGGKKASSDMSAGYEEISSPDLEEKPSLPPRKESIVKSQERGRQRMEQLRGSSPKPPGMILPMIPAKHTPPSRDSRRPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRPKAEPPEEKPEVPQNPFLKSKPQVRPKPTPSPRTEPPQGEDQVDICNLRSKLRKSQEKPLLDGEHQPAGGQDAAFSRDGPGRTQDRTAKQDGLSPKEMSCRAPPRPAKTADPVPKSVPAPLQEASPVVLPRRPPPPKKTTSSSRPLPEVRGPREANEGKTAPAPGRALLVPPKAKPFLSNGQDDMRGPGPRGENREKVAATPFPNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_027835791.2 SH3 and PX domain-containing protein 2B isoform X3 [Ovis aries] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPSPPKLGPGSPAHVGVLELDGVSRQQNSAGREKELLNNQRDGRIEGRPAPDSDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPSEVAQLRLGDTAATENSSGSEAGGPSRPLPDAPHGAGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGMILPMIPAKHAPPARDSRKAEPKPEKSKLFQPKNETGLECGHRVLAKEVKKPSLRPVSRSKAGPPEEKPEAPQNLFLKSKPQVRPKPAPSPRTEPPQGEDPVDICNLRSKLRKSQEKASVDGELQAGGGQDGAFSREGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSEGKAAPAPGRALLVPPKAKPFLSNGQDDMRGLGPRGENKEKVAAGPFPSTDGPKD-LYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_030867156.1 SH3 and PX domain-containing protein 2B isoform X1 [Gorilla gorilla gorilla] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGGDQTSVDPMVLEQYVVVANYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKPGPGSPSHPGALDLDGVSRQQNAVGREKELLSSQRDGRFEGRPVPDGDAKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPHEVTQLRLGEAAALENNTGSEATGPSRPLPDAPHGVMDSGLPWSKDWKGSKKASSDMSAGYEEISDPDMEEKPSLPPRKESIIKSRERERQRTEQLRGPTPKPPGMILPMMPAKHTPPARDSRRPEPKPDKSKLFQLKNDMGLECGHKVLAKEVKKPNLRPISKSKTDLPEEKPDAPQNPFLKSRPQVRPKPAPSPKTEPPQGEDQVDICNLRSKLRKSQDKSLLDGEPQAVGGQDVAFSREGPGRAQDRTGKQDGLSPKEISCRAPPRPAKTTDPVSKSVPVPLQEAPPVVPPRRPPPPKKTSSSSRPLPEIRGPCEGHESRAAPTPGRALLVPPKAKPFLSNGQDDTRSLGPRGENREKAAAASVPNADGLKDSLYVAVADFEGDKDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKK >XP_043743513.1 SH3 and PX domain-containing protein 2B [Cervus elaphus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVSRQQNSGGREKELLNNQRDGRFEGRPAPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHGTGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGMILPMIPAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPEAPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRKSQEKASVDGEHQAGGGQDGAFGREGPGRPQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKSAPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSESKAASAPGRALLVPPKAKPFLSNGQDDMRGPGPRGENKEKVAAGPFPNTDGPKD-LYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_043344822.1 SH3 and PX domain-containing protein 2B [Cervus canadensis] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVSRQQNSGGREKELLNNQRDGRFEGRPAPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHSTGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGMILPMIPAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPEAPQNLFLKSKPQVRPKPAPSPRTEPPQGEDQVDICNLRSKLRKSQEKASVDGEHQAGGGQDGAFGREGPGRPQDRTSKQEGPSPKEAPCRAPPRPAKTTDPVPKSAPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSESKAASAPGRALLVPPKAKPFLSNGQDDMRGPGPRGENKEKVAAGPFPNTDGPKD-LYVAVANFEGDQDTSSFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >KAB0369849.1 hypothetical protein FD755_018842 [Muntiacus reevesi] AHSSLMESEALPMDSSASNNTQSVYIIRVTWSSGSTEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPREEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPPKLGPGSPAHVGVLELDGVSRQQNSGGREKELLNNQRDGRFEGRPVPDGDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAAMENSSGSEASGPSRPLPDAPHGTGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGMILPMIPAKHAPPARDSRKPEPKPDKSKLFQLKNEMGLECGHKVLAKEVKKPNLRPISRSKADPPEEKPEASQNLFLKSKPQVRPKPASSPRTEPPQGEDQVDICNLRSKLRKSQEKASVDGEHQAGGGQDGAFSREGPGRPQDRTSKQEGPSPKEAPCRAPPRPTKTSDPVPKSAPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSEGKAAPAPGRALLVPPKAKPFLSNGQDDVRGPGPRGENKEKVAAGPFPNTDGPKD-LYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_018107654.1 SH3 and PX domain-containing protein 2B isoform X4 [Xenopus laevis] SRRSIVQVCVQDVQKRRSPNKHYVYIIKVTWSNGTTEVIYRRYSKFFDLQMQILDKFPVEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARVEDFNPPKEEPFGRKKLGGDSSSSDALVLDQYVVAAAYDKQESSEISLQVGQVVDIIEKNESGWWFVSTADEQGWVPATCLEAQDGGQDDFTIQPEEEEKYIVVYPYTARDQDEITLEKGYVVEVIQKNLEGWWKIRYKGSEGWAPASYLKKVSGDLLSQKLAAGSGANSSALDLDGITRQHSFTGQERESPAHLREGRIDTRPPHFADIKRKSPVLRQRPPPRRDLTIPRGLNLPTPPTPPHVEEEFYTIADFQTTISFQAGLKVEVIEKNHSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPNEMAQLCLGDANA-ENNTEEEATGPCRPLPEPPQNGTDSTSKWSKDWKGKDINGRDLGSVYDEAAG-DLEEKPNLPPRKESMLKTDASERTSMHQLRVPPSKPPSSLMAPIPQKIIP-SKETRKPELKNDKNKIFQLKNEMGIECGHKVSPKELKKPMLKPVNKPKPEPPTEKPDSAPNAFLKPKPVVRPKPVTAPKTD-PHNDDKVDISNLRSRLKKSIDKPN----DQE-FAGNGASSYGAAGRPQDRPDKQDGDGTREPPFKALPVPSRTVDSDLKGGMVSGKEP-PMIPPRRPPPPKKASVSSD-TTEGK--QKDSELTSSPLGNRPIMVPPRARPFNLSSNDDTKSFVPKKEIREKP-GFSLPTPEVSKETHYVAVADFDGDEDTSSFKEGTVFDVQEKSSGGWWFCRVLSGGPAWEGWIPSNYLRKK >XP_023818605.1 SH3 and PX domain-containing protein 2B isoform X1 [Oryzias latipes] -RRTVQEVTVQDVQKRRTPNKHYVYIIKVCWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRIFFETRPEDLNPPKEELMVKKKP-GDSTSGDALLLDQYVAVTDYEKQESSEISLRVGQVVEVIEKNESGWWFVSSEDAQGWVPATCLEVQDD-PDDFTLPGEEEEKYSVIYPYSARDQDEIDLERGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKS--DIQSQRQSAGAAAHASANDLEGISKQQNNA--------------KENRLSLFSDNNKSKVGSRHRPPPRRDLTIPRGTNLPKPPVPPLVEEEFYTIADFQTTISFQAGVKVEVIEKNGSGWWYIQIEEKEGWAPANFIDKYKKTSNALRPNFLAPLPNEMEKLCLEDGGS-SNVTDTDDTW-SKPLPDEPTTAQDTHTPKLRDWKSG-------FPLPPAPAAPPIEEKPALPPRRESINKSVEKPRSDHPKPLPPKPPAPGVIVPLVTPKTAPFKPDKPPEAKKEDKSKALYLKNEMGLECGHKVSAKEVKKFNLKPVPKPKSDVQEEKPEVGPAVLMKAKPVIRPKPAPAAKPE-ALAEKKVDITNLRSKLRKPLDQGSAEG-QNETVEPGN----QIPTLNSDKSSDESKITSKHRNALRKD----SSSPPSKPGVPPHKEP-PTMGPRRPPPPKKAEQLG--HTETK-PKEPQEIPKNGLPQLSRPPPPKPKGFPQPEKDECKPIPPKGPPKDKL---PPLLKDSSKEELYLAVADFEGDEQTSSFKVGTVFEVLEKNSSGWWFCKNV--GEDSEGWIPSNYLSKK >XP_021152892.1 LOW QUALITY PROTEIN: SH3 and PX domain-containing protein 2B [Columba livia] ------------AQLPGVPGLSWVYIIKVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPDDLTPPKEXPIGKKRSGADSASADPLVLEQYVVVANYQKQESSEISLCVGQLVDIIEKNESGWWFVSTSEEQGWVPATCLEAQDGVQDEFSMQPDEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWAPASYLKKGNGEMFSPKLGSGSSAHSCALDLDGISRQQVMVSREKDGLAGQRDGRFDSRPLPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTISFQAGMKVEVIEKNLSGWWYIQIEEKEGWAPATFIDKYKKTSNASRPNFLAPLPNEMAQLRLGDATA-DSSTGEEVTGPCRPLPEAPPNGTDCGGKWAKDWKGKE-ESGDLASGYEEILDRDAEEKPSLPPRKESIIKSLERQR--------PPPKPPGMILPMIPPKQSVAPKDSKKPELKPEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPITKPKAEPVEEKPEPAQNPFLKSRPQIRPKPAAAPRTDPAPADDKLDICSLRSKLRKCPEKPS----EQDTAAGESSLANEASGRFQERPSKVDSHAMKEVLPKSPLGPANT---------PGARDPPPVVPPXXXXXXA----------ELRAPREAPEIRSSPVPGRPMLVPPKAKPFLAAIQDEAKSISPKGEAKERT-SAPVPSPDISRDALYVAVADFEGDEETNSFKEGTLFEVREKNSSGWWFCKVLTGGPCWEGWIPSNYLRKK >XP_017921047.1 PREDICTED: SH3 and PX domain-containing protein 2B [Capra hircus] PRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGSTEAIYRRYSRFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHVGKKKSGGDLTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQGKEGWAPASYLRKSSGEPLPSKLGPGSPAHVGVLELDGVSRQQNSVGREKELLNNQRDGRIEGRPAPDSDIKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTISFQAGLKVEVIEKNLSGWWYIQIEDKEGWAPATFIDKYKKTSNASRPNFLAPLPNEVAQLRLGDAAATENSSGGEAGGPSRPLPDAPHGAGDSGTPWAKDWKGGKKASSDTSAGYEEISDPDLEEKPSLPPRKESIIKS--QERQRMEQFRGSSPKPPGVILPMIPAKHAPPARDSRKAEPKPEKSKLFQPKNETGLECGHRVLAKEVKKPSLRPVSRSKVGPPEEKPEAPQNLFLKSKPQVRPKPAPSPRTEPPQGEDPVDICNLRSKLRKSQEKASVDGELQAGGGQDGAFSREGPGRAQDRTSKQEGPSPKEAPCRAPPRPAKTADPVPKGAPVPLQEASPVVPPRRPPPPKKTSSSSRPLPEVRGPRESSEGKAAPAPGRALLVPPKAKPFLSNGQDDMRGLGPRGENKEKVAAGSFPSTDGPKD-LYVAVANFEGDQDTSGFQEGTVFEVREKNSSGWWFCQVQSGAPSWEGWIPSNYLRKK >XP_014374200.1 SH3 and PX domain-containing protein 2B [Alligator sinensis] -------LLKADEEMLRIP---WVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKKSGGDFASVD-LVLEQYVVVADYQKQESSEISLCVGQTVDIIEKNESGWWFVSTSDEQGWVPATCLEAQDGVQDEFSMQPEEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWAPASYLKKGSGEMFTQKLGSGSSTHSSALDLDGISRQQNSAGREKDGPNNQRDVRFDGRLQPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTISFQAGMKVEVIEKNLSGWWYIQIDEKEGWAPATFIDKYKKTSNASRPNFLAPLPNEMVQLRLGDVTV-EDSASEEATGPCRPLPEAPPNGMDCGTKWAKDWKGKD-ESGDLASGYEEIPDQDIEEKPSLPPRKESIIKSMERQR--------PPPKPPGMILPMIPPKQTPAPRDSKKPELKTEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPIAKPKAEPLEDKPEPTQNPFLKSRPQVRPKPAPAPRTDLPPVDDKLDICSLRSKLKKCQERSS----EQDPGASENSFSNDAPGWPQEQPSKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPPPVVPPRRPPPPKKATPCSSSTSDLKAPREVPDLRAASVPGRPMLVPPKAKPFLPAGQDEAKNLGPKGEAKERT-AAPFPNPDISKEALYVAVADFEGDEETNSFKEGTLFEVREKNSSGWGFCKVLTGGACWEGWIPSNYLRKK >XP_014453036.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Alligator mississippiensis] -RRSLVEVKVLDVQKRRVPNKHYVYIIRVTWSNGSTEVIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCEEVLQFFETRPEDLNPPKEEPIGKKKSGGDFASVD-LVLEQYVVVADYQKQESSEISLCVGQMVDIIEKNESGWWFVSTSDEQGWVPATCLEAQDGVQDEFSMQPEEEEKYTVIYPYTARDQDEMNLDRGAVVEVIQKNLEGWWKIRYQGQEGWAPASYLKKGSGEMFTQKLGSGSSTHSSALDLDGISRQQNSAGREKDGPNNQRDVRFDGRLQPNADIRRKSPKMRQRPPPRRDLTIPRGLNLPKPPVPPQVEEEYYTIADFQTTISFQAGMKVEVIEKNLSGWWYIQIDEKEGWAPATFIDKYKKTSNASRPNFLAPLPNEMVQLRLGDVTV-EDSASEEATGPCRPLPEAPPNGMDCGTKWAKDWKGKD-ESGDLASGYEEIPDQDIEEKPSLPPRKESIIKSMERQR--------PPPKPPGMILPMIPPKQTPAPRDSKKPELKTEKGKLFQLKNEMGLECGHKVSAKEVKKPNLRPIAKPKAEPLEDKPEPTQNPFLKSRPQVRPKPAPAPRTDLPPVDDKLDICSLRSKLRKCQERSS----EQDPGASENSFSNDAPGWPQEQPSKQDSQIPKEAPPKAPFGPAKTTDSEPKNGFPIVREPPPVVPPRRPPPPKKATPCSSSTSDLKAPREVPDLRAAPVPGRPMLVPPKAKPFLPAGQDEAKNLGPKGEAKERT-AAPFPNPDISKEALYVAVADFEGDEETNSFKEGTLFEVREKNSSGWWFCKVLTGGSCWEGWIPSNYLRKK >XP_015816888.1 PREDICTED: SH3 and PX domain-containing protein 2B isoform X1 [Nothobranchius furzeri] -RRTAQEVIVQDVQKRRIPSKHYVYIIKVSWSDGSTETIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKRAAGDSNSADPLLLEQYVAVTDYEKQESTEISLHVGQVVEVIEKNESGWWFVSSEDAQGWVPATCLEAQDD-PDDFTLPGEEKEKYSVIYPYSARDQDEIDLEKGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKA--DIQSQRQSAGAAAHASTNDLEAFSKQQNNAARE-----NRDN-QKENRLSFFSDNK--KVGLRHRPPPRRDLTIPRGTNLPKPPVPPQVEEEYYTIADFQTTISFQAGVKVEVIEKNASGWWYIQIDDTEGWAPATFVDKYKKTSNALRPNFLAPLPNEMEKLRQEDGGS-SNVSGKDDTW-SKPLPDEPTTGSESCAPKLRDWKSNP--GTSAFPLPPAPAAPPAEEKPALPPRRESINKSAEKAKSDHSKPLPPKPPAPGVIMPHVAPKMPPFKPEKPTEVKKDDKNKALYLRNEMGLECGHKVSAKEVKKFNLKPVPKPKPEIQEEKPEAGPASFIKAKPVIRPKPAPAAKPE-GQADDKLDITNLRSKLRKPADLGSASAEQNDTSATGNGFHPHIPSVNNGKCS-EPKLPTKHTNGLSQE----RSSPSAKPAVPPHKEL-PTMAPRRPPPPKKTDPSS--PTEPKSPKEPQEVPRPGPPQLSRPPPPKPKGFVHPENNEPRPIPPKGPPKDKL---PPLLKDSSKDELYLAVADFEGDEQTSSFKVGTVFEVLEKNSNGWWFCKNV--GEEVEGWIPSNYLSKK >XP_030294651.1 SH3 and PX domain-containing protein 2B isoform X1 [Sparus aurata] -RRTVHEVTVQDVQKRRNPNKHYVYIIKVSWSDGSTEVIYRRYSKFFDLQMELLDKFPVEGGQKDPKRRIIPFLPGKILFRRSHIRDVAMKRLRPINEYCRALIQLPVYISQCEEVRVFFETRPEDLNPPKEEPIGKKKS-GDSSAGDPLLLDQYVAVTDYEKQESSEVSLHVGQVVEVIEKNESGWWFVSSEDAQGWVPATCLEAQDD-PDDFTFPGEEEEKYSVIYPYSARDEDEIDLERGMIVEVIQKNLEGWWKIRYQGREGWAPASYLKKS--DIQSQKQSAGGAVHASTNDLD--SKQQNNAAKE-----NRDNGHKENRLSFFSDK---KVGSRHRPPPRRDLTIPRGANLPKPPIPPQVEEEFYTIADFQTTISFQAGIKVEVIEKNASGWWYIQIDDKEGWAPATFIDKYKKTSNALRPNFLAPLPNEMEKLSLADGVS-SNASGTDDSW-SKPLPDEPPTAPESCAPKLRDWKSGP--GG---PLPPAPAAPPVEDKPALPPRRESINKSAEKPRPDHSKPLPPKPPAPGVIMPMVPPKAPPLKQDKPPETKKEDKSKPLLLRNEMGLECGHKVSAKEVKKFNLKPVPKPKSEAPEEKPEAGPAVFMKAKPVLRPKPPPAAKPD-PPSENKLDITNLRSKLRKPADL--------ETPAAGNNPQPHIPSLNNGKHCDEPKLPPKHINGHSQE----SSSPPAKPAVPPHKEP-PAMAPRRPPPPKKETPSS--PTELKPPKEIQDVPKIPPPQLNRPPPPKPKGFVAPEKEEPKPIPPKGPPKDKL---PPLLKEPSKDELYLAVADFEGDDNTSSFKVGTVFEVLEKNGSGWWFCKNV--REEVEGWIPSNYLSKK >XP_040200471.1 SH3 and PX domain-containing protein 2B isoform X1 [Rana temporaria] -RKSIVQVNVQDVQKRRSPNKHYVYIISVSWSNSSSEVVYRRYSKFFDLQMQLLDKFPVEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVRRLIPIDEYCKALIRLPAYISQCDEVLQFFEARLEDFNTPKEEHIGRRKFGADSASADPLVFDQYVVVAPYDEQESSEISLQVGQVVDIIEKNESGWWFVSTADEQGWVPATCLEAQDGGQDDFTIQPEEDEKYSVIYPYIARDQDEITLDKGVIVEVIQKNLEGWWKIRYKGAEGWAPASYLKKISGDLLAQKLASGSSANSSALDLDGLSRQQNFTSRDRDVP---------GRQAHVTDFKRKSPILRQRPPPRRDLTIPRGLNLPKPPTPPHVEEEYYTIADFQTTISFQAGLKVEVVEKNHSGWWYIQIDDKEGWAPATFIDKYKKTSNALRPNFLAPLPNEMAQLCLSNAST-ENTSVEEASGPCRPLPEPPQNGTDPVSKWSKELKNKDLDGKEHFSVYDEAAVDDGEEKPSLPPRRESMLKTEVSERPSMPQHRAPPPKPLTSMMASSPQKQLP-SKEVKKPEIKNDKSKMFQLKNEMGLECGHKVSPKELKKPMLKPVNKPKPEISSEKPELVPNPFLKAKPQVKPKPVATTKTE-GSSEDKVDISNLRSRLKKSLDKGN----EQEPCASSGVSDTGAAGRPFDKPDKQNNSIPGEPPSKALPVPLRTVDTEPK----AARDL-PVIPPRRPPPPKKVSMSCE-TNEGRATKESSDFTVAHMANRPIMVPPKSKPLISLGSDDTKSFVPKSETKEKP-VSSTP------PSQYVAVADFDGDEDTSSFKEGTIFEVQEKSSNGWWFCRVLSGGPTWEGWIPSNYLRKK >XP_038045303.1 SH3 and PX domain-containing protein 2A-like isoform X4 [Patiria miniata] -RRTVQDAIVDDIQKRKYPTKHYEYVIHVSWSDGSVNVVYRRYSKFFDFQMKLLSIFPEEAGARNPTQRMIPFLPGKKLFGRSQTREVASRRLGQLNEYCQLLVRLPPKISESDEVLQFFTPTAEDINPVTERGVIKKGAKEIDVISDPIQPDPYIVIADYKKQQKNEVDLHTGDNVEVFEKNDNGWWFVSSNDSQGWAPATFLSRADGGDDEDLAGGGTEERYISNNSYKAQQEDEVSFETGVVLIVMQKSLDGWWKVRYKEKIGWVPAAFLQVYTG---PADVTASTPTQRVGNVMDIISRRQAAD---------------SSKNSPMLGRKDNSHGTEAKPPPRRTTTVRKGATRKRRPTATKKTLEYYTVADFSDSISFKSGQKVQIIQETESGWWLVKIGDEEGWAPSSYMEAKEETVAETRPQ-----PSNRESL--------DEETGESSP--RPPRPPPPTGRKISNGGATSSSSGTG----------------------STPG-----------------------GSKSSGAASAFRPVSMPSS-------------------------------------NNGRPL--------PVTPAFPAPPALKPTPQTQPKPFRPSSGG---GSN--LIQNAQANLKRSQSKPPLVNR-------------------------------------------------------------PGAQPNGSPIGT----------------------------------------------------PGADLQNQLKPSSGGVRDRRPSNAYVTTAAYENDDDGLSFEEGVQVEVIEENDTGWWLVRI----AGEEGWAPSTYLEKA >XP_030842214.1 SH3 and PX domain-containing protein 2A isoform X3 [Strongylocentrotus purpuratus] -KRTVVNANVTDIEKRREPTKHYVYIIHVTWSDGSVNVVYRRYSTFFDFQNKLLSKFPEEAGANNPSSRCIPFLPGKKLFGRSHIREVALKRLSPIDEYCTALVKLPGKISDSKEVINFFTPTPEDVSPPSPDGGGESTRADIGNISEPIQAEQYIVVADYKKQQKNEVELTAGDLVEVFEKNDNGWWFVTVHDQHGWAPGTFLQNPDGQEEEDTLIPGNDESYITNNAYQGQAEDEISFETGVVVTVIQKSLDGWWKVSYQGKQGWAPATFLQIYKG---PSGVTPKHPTQSIGNVM------SGSDSKPKP---GPGPGS-SGRPQPPVQPRDENYDAEVKPPPRRATSVRRGGVRQKPKLKKVM--EHYTTDSFQGAISFESGQKVEVLEENDGGWWYVKMNGQEGWAPSNYIEKREVSSRINGKPSLGNL---------------DEETGEDKV--PPVLPARPAF----------GSGGSG------------------VAKKSTPP-----------------------PVDRSNSPSFTNRKAVT---------------------------------------NNGRGG---------------------------GDGVRRGSGGVGAGGN--MMAALKKQLEGESSSPAI----------------------------------------------------------------PGVAPKLSKPTAQ---------------------------------------------------PY-----------------NRDAAYITTSSYVNENDGLSFKEGQRVEVIKKDDSGWWSVRI----GNTEGWVPNTFLEKI >XP_031561245.1 SH3 and PX domain-containing protein 2A-like [Actinia tenebrosa] -KRTLTSVKIVDIQKRKVPSKHYVYVISVTWSDGSVNVVYRRYSKFFDLQTKLLEEFPVEGGVQNPSTRVIPFLPGKIIFGRSHVRDVALKRKESIDEYCSKLIELDPKLSQSDLVLKFFEPSSDDIDIPAEKK--KKKNETADNISDPISLDQYVAIADYQKQNRNEISMAAEDVVEVIDKNENGWWFVNLDEEQGWVPAAYLEPLDGPSDDMDVSSVEENQFITTTSHIAELDDEISFEMGVIVTVVKKNFDGWWLIRYQNKEGWAPAMYLKKPDP---MQLHAAEIG--------GAVPKRVPVITHAPIM---QQPTS--------------NLARKGKGPPRKAS-VKRSIRKPKETAAIHSEAEYVTIGDFRAVLSFDKGEAVEILDKSPNGWWLGKIGGHEGWIPSSYVEKRNRSQKG---NVVTPKPDRSSRLSISEIKP-SMRLKSCAA--SEPAEPSGQSSTKEMYAAVSDFEDSS---KEGDEVVDKSEGEWLNEKQGWVP-SSYLTKQEIKNSPAPRRPK-PPASKPSSSSQGASKPALPAIP-SSKPVSSQKMNKPSGKPGTLRKTDGKPLPS---PVLSGKPATLQKTNGKPTPPPVSAKPTLAQKPKAKPSPHPVPKGK------------------------------------------------------------------------------------------TTAKPVPPPVPSTKSVSQKLPVSSRNPDSLQNQQHKPVVKQNSPVSNKKDDNINRGKLNTAIFAPQETPSKKIPKPTRNEPAKPSASQCVAIAAFTNDQDGLSFSEGDLFDFLEDSGSGWWLVKTQA--TNREGWAPSSYLEMK >CAE1310922.1 SH3PXD2 [Sepia pharaonis] -RKSVTAVEVVDVEKRRLPSKHYVYVIQVTWDDGSSITIYRRYSNFFDLQTSLLETFPEEGGQLNPDERTIPFLPGKKYFGRSHIREVAEKRLGPIDKYCKLLIKLDKKISQCHEVLTFFEPTADDLSPKSQEK------PGEAKISKPKVLEQYEAIFDYQKQAKDQVDLKVGQSVQVIEKYETGWWLVNTEYEEGYAPGTFLQKTDGQEEEQ-MFTCNGEKYICIQSYTAEVPDDHTLNIGAEVEVLQKSLDGWWWVRYKGKIGWAPATCLKVADS---ISRHSANIPVEIVSNL-SDVSKLGNDTTADSPMTVSQRPKSFSSASVQDSDNYEENTSHTVVPPPRQKSIRDKG------KVPMNAEEKFITCAEYIDSISFSAGQEVEVQQKTDSGWYYIKLGNEFGWAPSSYLEEIPLDETHVRFDKIQEEKAEYETINLCPAKQIRNSSSSDEL--KLPLSSSPTGSSSSACPKRPDHPGGQVSSATKIQLPPPPPPPSSVPKKPVPPSSTGLYKS---SKTSATCPPQPPPPPPGRPYSGISHPLTNSVADHSKETSNTSGNLATELQSRLAKLKANFDSGSSANTKKQQPLVTKTKDIKKSQPQVLPH-VQKTTPILPASPSNVDNSPSQAEKDRIPVPNVSDSSVKFAEKLSVFQMNGDNAAATPKFSSALLQRQKDKLMTSSSVPPDQSTNVKPAPPTKPIHK-VKPTTVPAKANPPKVSPCKPKFGAVTSTTNIKINKFGGNASPAKISAAEM------EPPKFQLVKEK------VMTPTKEMRTSNTNSVIQRAPKSTDRSYKASSRYIASEGEVSFEKGVDIEVLEKHESGWWLVHI----GDEEGWAPSNHIAEL >XP_039260717.1 SH3 and PX domain-containing protein 2A-like isoform X2 [Styela clava] GRRTLVKVEVGDAEKRRIPSKHYSYVIKVWWDDDSETVVYRRYSKFFEFQIILLETFPYEGGLKEPSARIIPFLPGKILFRRSHVRDVAMKRLKPIDEYCKALIKLPSHISKCNHVLDFFETRQEDLNPSREEGSRRRKRQEIGEISGPLLLEQYVAIADYNSTQQKELTMTIGQKVEVIEKNENGWWFVSNDEERGWVPGVYLEKPDGTVEDLRAEPGQGEHYVTTNAYVAENSDDISFGAGVIVEVLQKNLEGWWLVSYNGRQGNAPASYLEKS-----HNWVPENNKVEIISSI-HDLKHRLPANSLSSIAFPSQRIVNSSSNSKPIPAEVHSFREKTVQPPPKKSSVKRTNKRRPPPPLPPSAAAEYTTVASFDSNISFKDDKKVEVLEKSPGGWWYVNIDGSEGWAPASYIEKKETKPKTSRPGPPKLLKNNTNSFSITAAGRSRNQSSMSPA--KRPLPPLPTSVSSSNVQDCSDTYEEVKFGASKSPAVPKSTAKPESQKVETTPVFRSVLKSEIKTRSAQSPPR--PSTNPSPLSNVMKPKIQPNNI-NLRPKTTTSTQKPSNVRNSVTRMNSNETSS---AVNNLKPVGGKTAEGPPRLPP-------KPKPGLNSVKAKPVQGNVPTNDD--AITDFRSVLRQRKQSASTNGV-------------RSKSFNSDKVI-----------------STKKVEQGNKPPFV------PANMPLKPPVPTKMTTTTRVIRRFQTNSNVDEVQKKPVLKIELKNPPDLTKSLPKGQVDCKTITPPHNPKNSKSNLQKTESNDSSSNFCIAMSDYTGEECEISFQSGDRAELLEKGDNDWWYIKM----GENVGWAPSTYFKLT
PhyML tree of selected proteins (XP_030842214_1_SH3_and_PX_domain_containing_protein_2A_isoform_X3__Strongylocentrotus_purpuratus_:0.85980682,XP_038045303_1_SH3_and_PX_domain_containing_protein_2A_like_isoform_X4__Patiria_miniata_:0.69997661,(CAE1310922_1_SH3PXD2__Sepia_pharaonis_:1.78789621,((XP_031561245_1_SH3_and_PX_domain_containing_protein_2A_like__Actinia_tenebrosa_:1.53409295,XP_039260717_1_SH3_and_PX_domain_containing_protein_2A_like_isoform_X2__Styela_clava_:1.26051321):0.17986736,((XP_005170345_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Danio_rerio_:0.16520009,(XP_030294651_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Sparus_aurata_:0.0874632,(XP_023818605_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Oryzias_latipes_:0.13306796,XP_015816888_1_PREDICTED__SH3_and_PX_domain_containing_protein_2B_isoform_X1__Nothobranchius_furzeri_:0.08899366):0.02996248):0.1392584):0.32497862,((XP_018107654_1_SH3_and_PX_domain_containing_protein_2B_isoform_X4__Xenopus_laevis_:0.1458429,XP_040200471_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Rana_temporaria_:0.19450677):0.23366894,((((XP_546237_7_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Canis_lupus_familiaris_:0.04077078,XP_023115375_1_SH3_and_PX_domain_containing_protein_2B__Felis_catus_:0.03623258):0.01287219,((XP_002816245_4_SH3_and_PX_domain_containing_protein_2B__Pongo_abelii_:0.00516421,(XP_030867156_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Gorilla_gorilla_gorilla_:0.00127289,(sp_A1X283_SPD2B_HUMAN_SH3_and_PX_domain_containing_protein_2B_OS_Homo_sapiens_OX_9606_GN_SH3PXD2B_PE_1_SV_3:0.00386798,(XP_034816856_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Pan_paniscus_:0.00127727,XP_016809693_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Pan_troglodytes_:0.00128045):0.00128012):0.00128809):0.00265487):0.05493269,(XP_017196747_1_PREDICTED__SH3_and_PX_domain_containing_protein_2B_isoform_X1__Oryctolagus_cuniculus_:0.07806608,(NP_796338_2_SH3_and_PX_domain_containing_protein_2B__Mus_musculus_:0.02360829,XP_017453105_1_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Rattus_norvegicus_:0.01809185):0.06718604):0.01063905):0.02085324):0.01312937,(XP_020932748_1_LOW_QUALITY_PROTEIN__SH3_and_PX_domain_containing_protein_2B__Sus_scrofa_:0.05701381,((KAB0369849_1_hypothetical_protein_FD755_018842__Muntiacus_reevesi_:0.03590312,(XP_043743513_1_SH3_and_PX_domain_containing_protein_2B__Cervus_elaphus_:0.00000001,XP_043344822_1_SH3_and_PX_domain_containing_protein_2B__Cervus_canadensis_:0.00130476):0.00384671):0.00562599,(XP_024837195_1_SH3_and_PX_domain_containing_protein_2B__Bos_taurus_:0.01284027,(XP_027835791_2_SH3_and_PX_domain_containing_protein_2B_isoform_X3__Ovis_aries_:0.00525009,XP_017921047_1_PREDICTED__SH3_and_PX_domain_containing_protein_2B__Capra_hircus_:0.00661191):0.01570589):0.01259816):0.02567586):0.00865517):0.19261076,((XP_014453036_1_PREDICTED__SH3_and_PX_domain_containing_protein_2B_isoform_X1__Alligator_mississippiensis_:0.00000001,XP_014374200_1_SH3_and_PX_domain_containing_protein_2B__Alligator_sinensis_:0.02044133):0.06326255,(XP_021152892_1_LOW_QUALITY_PROTEIN__SH3_and_PX_domain_containing_protein_2B__Columba_livia_:0.06919466,(XP_025010804_2_SH3_and_PX_domain_containing_protein_2B_isoform_X1__Gallus_gallus_:0.01000783,XP_019475954_2_SH3_and_PX_domain_containing_protein_2B__Meleagris_gallopavo_:0.04209939):0.04171161):0.06529644):0.09224986):0.08139089):0.20546434):0.94600115):0.28026083):0.52560541);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)