Click here to access PB0234 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0234 P08648 Integrin alpha-5 ITGA5 CD49e, FNRA, VLA-5, VLA5A, integrin subunit alpha 5 Homo_sapiens (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

DomainsGene Ontology
PF01839 (2_FG-GAP)
PF08441 (Integrin_alpha2)
GO:0005911 (colocalizes with) cell-cell junction
GO:0032587 (colocalizes with) ruffle membrane
GO:0001618 (enables) virus receptor activity
GO:0005154 (enables) epidermal growth factor receptor binding
GO:0005161 (enables) platelet-derived growth factor receptor binding
GO:0005178 (enables) integrin binding
GO:0005515 (enables) protein binding
GO:0043184 (enables) vascular endothelial growth factor receptor 2 binding
GO:0046872 (enables) metal ion binding
GO:0050839 (enables) cell adhesion molecule binding
GO:0001525 (involved in) angiogenesis
GO:0007044 (involved in) cell-substrate junction assembly
GO:0007155 (involved in) cell adhesion
GO:0007157 (involved in) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO:0007159 (involved in) leukocyte cell-cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0007229 (involved in) integrin-mediated signaling pathway
GO:0007565 (involved in) female pregnancy
GO:0007613 (involved in) memory
GO:0010811 (involved in) positive regulation of cell-substrate adhesion
GO:0023035 (involved in) CD40 signaling pathway
GO:0030335 (involved in) positive regulation of cell migration
GO:0030949 (involved in) positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031589 (involved in) cell-substrate adhesion
GO:0033627 (involved in) cell adhesion mediated by integrin
GO:0033631 (involved in) cell-cell adhesion mediated by integrin
GO:0034113 (involved in) heterotypic cell-cell adhesion
GO:0035313 (involved in) wound healing, spreading of epidermal cells
GO:0035987 (involved in) endodermal cell differentiation
GO:0045765 (involved in) regulation of angiogenesis
GO:0046718 (involved in) viral entry into host cell
GO:0050731 (involved in) positive regulation of peptidyl-tyrosine phosphorylation
GO:0098609 (involved in) cell-cell adhesion
GO:1903672 (involved in) positive regulation of sprouting angiogenesis
GO:2000811 (involved in) negative regulation of anoikis
GO:0001726 (located in) ruffle
GO:0005737 (located in) cytoplasm
GO:0005783 (located in) endoplasmic reticulum
GO:0005794 (located in) Golgi apparatus
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0009897 (located in) external side of plasma membrane
GO:0009986 (located in) cell surface
GO:0016020 (located in) membrane
GO:0016021 (located in) integral component of membrane
GO:0031410 (located in) cytoplasmic vesicle
GO:0045202 (located in) synapse
GO:0070161 (located in) anchoring junction
GO:0008305 (part of) integrin complex
GO:0034674 (part of) integrin alpha5-beta1 complex
GO:0071062 (part of) alphav-beta3 integrin-vitronectin complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)