Click here to access PB0226 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0226 P17655 Calpain-2 catalytic subunit CAPN2 CANP2, CANPL2, CANPml, mCANP Homo_sapiens Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity).

DomainsGene Ontology
PF00648 (Peptidase_C2)
PF01067 (Calpain_III)
PF13833 (EF-hand_8)
GO:0045121 (colocalizes with) membrane raft
GO:0004198 (enables) calcium-dependent cysteine-type endopeptidase activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008092 (enables) cytoskeletal protein binding
GO:0008233 (enables) peptidase activity
GO:0008234 (enables) cysteine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0019899 (enables) enzyme binding
GO:0044877 (enables) protein-containing complex binding
GO:0046872 (enables) metal ion binding
GO:0001666 (involved in) response to hypoxia
GO:0001824 (involved in) blastocyst development
GO:0006508 (involved in) proteolysis
GO:0007520 (involved in) myoblast fusion
GO:0007565 (involved in) female pregnancy
GO:0009612 (involved in) response to mechanical stimulus
GO:0010666 (involved in) positive regulation of cardiac muscle cell apoptotic process
GO:0016540 (involved in) protein autoprocessing
GO:0030163 (involved in) protein catabolic process
GO:0032675 (involved in) regulation of interleukin-6 production
GO:0035458 (involved in) cellular response to interferon-beta
GO:0042542 (involved in) response to hydrogen peroxide
GO:0048266 (involved in) behavioral response to pain
GO:0051493 (involved in) regulation of cytoskeleton organization
GO:0051603 (involved in) proteolysis involved in protein catabolic process
GO:0071222 (involved in) cellular response to lipopolysaccharide
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:1901216 (involved in) positive regulation of neuron death
GO:1901741 (involved in) positive regulation of myoblast fusion
GO:2001247 (involved in) positive regulation of phosphatidylcholine biosynthetic process
GO:0000785 (located in) chromatin
GO:0005634 (located in) nucleus
GO:0005737 (located in) cytoplasm
GO:0005758 (located in) mitochondrial intermembrane space
GO:0005764 (located in) lysosome
GO:0005783 (located in) endoplasmic reticulum
GO:0005794 (located in) Golgi apparatus
GO:0005829 (located in) cytosol
GO:0005886 (located in) plasma membrane
GO:0005925 (located in) focal adhesion
GO:0009897 (located in) external side of plasma membrane
GO:0016020 (located in) membrane
GO:0030425 (located in) dendrite
GO:0030864 (located in) cortical actin cytoskeleton
GO:0031143 (located in) pseudopodium
GO:0042995 (located in) cell projection
GO:0043025 (located in) neuronal cell body
GO:0070062 (located in) extracellular exosome
GO:0097038 (located in) perinuclear endoplasmic reticulum
GO:0110158 (located in) calpain complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)