PB0213

DATABASE

Click here to access PB0213 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0213	O60565	Gremlin-1	GREM1v	C15DUPq, CKTSF1B1, CRAC1, CRCS4, DAND2, DRM, DUP15q, GREMLIN, HMPS, HMPS1, IHG-2, MPSH, PIG2, DAN family BMP antagonist	Homo_sapiens	Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity).

Domains

Gene Ontology

PF03045 (DAN)

GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0005125 (enables) cytokine activity GO:0005515 (enables) protein binding GO:0016015 (enables) morphogen activity GO:0030297 (enables) transmembrane receptor protein tyrosine kinase activator activity GO:0036122 (enables) BMP binding GO:0042803 (enables) protein homodimerization activity GO:0043184 (enables) vascular endothelial growth factor receptor 2 binding GO:0048018 (enables) receptor ligand activity GO:0000902 (involved in) cell morphogenesis GO:0001525 (involved in) angiogenesis GO:0002042 (involved in) cell migration involved in sprouting angiogenesis GO:0002092 (involved in) positive regulation of receptor internalization GO:0002689 (involved in) negative regulation of leukocyte chemotaxis GO:0003337 (involved in) mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0006915 (involved in) apoptotic process GO:0007165 (involved in) signal transduction GO:0007171 (involved in) activation of transmembrane receptor protein tyrosine kinase activity GO:0007267 (involved in) cell-cell signaling GO:0008284 (involved in) positive regulation of cell population proliferation GO:0009887 (involved in) animal organ morphogenesis GO:0009954 (involved in) proximal/distal pattern formation GO:0010717 (involved in) regulation of epithelial to mesenchymal transition GO:0030199 (involved in) collagen fibril organization GO:0030308 (involved in) negative regulation of cell growth GO:0030326 (involved in) embryonic limb morphogenesis GO:0030502 (involved in) negative regulation of bone mineralization GO:0030514 (involved in) negative regulation of BMP signaling pathway GO:0032331 (involved in) negative regulation of chondrocyte differentiation GO:0033689 (involved in) negative regulation of osteoblast proliferation GO:0038098 (involved in) sequestering of BMP from receptor via BMP binding GO:0043066 (involved in) negative regulation of apoptotic process GO:0043542 (involved in) endothelial cell migration GO:0045668 (involved in) negative regulation of osteoblast differentiation GO:0045766 (involved in) positive regulation of angiogenesis GO:0045892 (involved in) negative regulation of DNA-templated transcription GO:0045893 (involved in) positive regulation of DNA-templated transcription GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II GO:0046851 (involved in) negative regulation of bone remodeling GO:0048263 (involved in) determination of dorsal identity GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity GO:0051893 (involved in) regulation of focal adhesion assembly GO:0051973 (involved in) positive regulation of telomerase activity GO:0055007 (involved in) cardiac muscle cell differentiation GO:0060173 (involved in) limb development GO:0060379 (involved in) cardiac muscle cell myoblast differentiation GO:0060394 (involved in) negative regulation of pathway-restricted SMAD protein phosphorylation GO:0060676 (involved in) ureteric bud formation GO:0061098 (involved in) positive regulation of protein tyrosine kinase activity GO:0090027 (involved in) negative regulation of monocyte chemotaxis GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:0090190 (involved in) positive regulation of branching involved in ureteric bud morphogenesis GO:0090291 (involved in) negative regulation of osteoclast proliferation GO:1900086 (involved in) positive regulation of peptidyl-tyrosine autophosphorylation GO:1900155 (involved in) negative regulation of bone trabecula formation GO:1900158 (involved in) negative regulation of bone mineralization involved in bone maturation GO:1901224 (involved in) positive regulation of NIK/NF-kappaB signaling GO:2000273 (involved in) positive regulation of signaling receptor activity GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0009986 (located in) cell surface

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|O60565|GREM1_HUMAN Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 PE=1 SV=1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS IDLD >sp|O60565-2|GREM1_HUMAN Isoform 2 of Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKALHVTERKYLKRDWCKTQPLKQ TIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPEL QPPTKKKRVTRVKQCRCISIDLD >tr|Q6T937|Q6T937_DANRE Gremlin OS=Danio rerio OX=7955 GN=grem1a PE=2 SV=1 MTKDALAVTIVVLWLLCNPARIRGTGGFQGAIPHPNKYSPNQSEQSPQTPQAGSRGMGPP SAGDEVLDSSQEALHVTERRYLKLDWCKTQPLKLMIYEDGCQPRAIINRFCYGQCNSFYI PRHIYQEDGAFQSCSVCKPKSFTTVTYTLFCPGQTPNTKKKRVRRVKQCRCTSVDLD
Selected proteins from model organisms >sp|O60565|GREM1_HUMAN Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 PE=1 SV=1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS IDLD >sp|O60565-2|GREM1_HUMAN Isoform 2 of Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKALHVTERKYLKRDWCKTQPLKQ TIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPEL QPPTKKKRVTRVKQCRCISIDLD >tr|Q6T937|Q6T937_DANRE Gremlin OS=Danio rerio OX=7955 GN=grem1a PE=2 SV=1 MTKDALAVTIVVLWLLCNPARIRGTGGFQGAIPHPNKYSPNQSEQSPQTPQAGSRGMGPP SAGDEVLDSSQEALHVTERRYLKLDWCKTQPLKLMIYEDGCQPRAIINRFCYGQCNSFYI PRHIYQEDGAFQSCSVCKPKSFTTVTYTLFCPGQTPNTKKKRVRRVKQCRCTSVDLD >NP_035954.1 gremlin-1 precursor [Mus musculus] MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >NP_062155.1 gremlin-1 precursor [Rattus norvegicus] MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >NP_990309.1 gremlin-1 precursor [Gallus gallus] MVRTLYAIGAVFLLTGFLLPTAEGRKRNRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERGKGTSMPA EEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVRKEEGSFQS CSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISIDLD >XP_523036.4 gremlin-1 [Pan troglodytes] MPGTRCAFRGPGDPVHGRRVTLGPADPAPSPGGSGRGRTQRHASKAQAPRTRRTDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_005638258.1 gremlin-1 [Canis lupus familiaris] MSRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_024853495.1 gremlin-1 isoform X1 [Bos taurus] MPLTRCALRGPGDPVCRKSGTLCPADPTRSPGGSGRGRTPRHASRAQAPKARCIDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_020953969.1 gremlin-1 isoform X2 [Sus scrofa] MPCTRCALRGPGDPVCGESGTLCPAEPAPSPGGSGRGRAHRHASRAQAPKARRTDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_008267474.1 PREDICTED: gremlin-1 [Oryctolagus cuniculus] MPDTRCALRGPGDPVHSRSLPLGSADPTPSPGGSGRGRTQRHASRAQAPKPRRPDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSLQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_002825289.3 gremlin-1 [Pongo abelii] MPGTRCAFRGPGDPVHGRCVTLGLADPAPSPGGSGRGRTQRHASKAQAPRTRRTDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_010709901.1 gremlin-1 [Meleagris gallopavo] MVRTLYAIGAVFLLMGFLLPTAEGRKRNRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERGKGTSMPA EEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVRKEEGSFQS CSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISIDLD >XP_017909987.1 PREDICTED: gremlin-1 [Capra hircus] MPLTRCALRGPGDPVCRKSGPLCPADPTRSPGGSGRGRTPRHASRAQAPKARRVDSMSRTAYTVGALLLL LGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVT ERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMV TLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_003805004.2 gremlin-1 [Pan paniscus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_011281387.1 gremlin-1 [Felis catus] MSRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_012036542.3 gremlin-1 isoform X1 [Ovis aries] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_030858273.1 gremlin-1 isoform X1 [Gorilla gorilla gorilla] MCLRRRAGCGGVLGRPLESAGWSIRRIHDACICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAI PPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTI HEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRV KQCRCISIDLD >XP_005502506.1 gremlin-1 [Columba livia] MVRTLYAIGAVFLLTGFLLLAAEGRKRNRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERGKGTSMPA EEVLESSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVRKEEGSFQS CSFCKPKKFTTMTVTLNCPELQPPRKKKRITYRLGLS >XP_006018557.1 gremlin-1 [Alligator sinensis] MGRTVYAVGALLLLLGLLFPTGEGRKRNRGSQGAIPPPDKDQPNDSEQTQTQQQSGSRNRERGKGTSMPA EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVHKEEGSFQS CSFCKPKKFTAMTVTLNCPELQPPRKKKRITRVKECRCISIDLD >XP_006276353.1 PREDICTED: gremlin-1 [Alligator mississippiensis] MGRTVYAVGALLLLLGVLLPTGEGRKRNRGSQGAIPPPDKDQPNDSEQTQTQQQSGSRNRERGKGTSVPA EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHVHKEEGSFQS CSFCKPKKFTAMTVTLNCPELQPPRKKKRITRVKECRCISIDLD >XP_015803163.1 PREDICTED: gremlin-1 [Nothobranchius furzeri] MMQPHSLRIFAAVFAMFHIPPSSADTGAVQGAFPHPNKYNPNESEGCLMPPIGGLLSRGTASATSSTDEV LESSQEALLVTERRYLRLDWCKTQPLKQTIQEEGCLSRTIINRFCYGQCNSFYIPRHTHQDGSVFQSCSA CKPKTFSTVTYTLFCPGKTPSTRRKRVQRVKQCRCTTVKTE >XP_020761931.1 gremlin-1 [Odocoileus virginianus texanus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPG EEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQS CSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_030261039.1 gremlin-1 [Sparus aurata] MKTPSVLISTAVLALLLSSPRSTDADTFQGAIPHPNKYDPQEPDRCQQPAIGGLISRGAGPVTSTDEVLE SSQEALHVTERRYLRLDWCKTQPLKQTIREEGCLSRTIINRFCYGQCNSFYIPRHNYQDGDVFQSCSACK PKTFSTVTYTLFCPGQTPSTRKKRIQRVKLCRCTTIDTD >XP_040188088.1 gremlin-1 [Rana temporaria] MNRLVYTLGPMFLLFGLLLPNTEGNKKVRGSQGAIPPPDKGQANDSEQSQTHPGNRNGGKGKGQALVAEE VLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCIKRTILNRFCYGQCNSFYIPRHIRREEGSFQSCS FCKPKKFTSMVVTLNCPELQPPIKKKRITRVKQCRCISIDLD >XP_043776518.1 gremlin-1 isoform X2 [Cervus elaphus] MSDVSICLSSSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMP GEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKF TTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >XP_043327329.1 gremlin-1 isoform X1 [Cervus canadensis] MPLTRCALRGPGDPVCRKSGALCPADPTRSPRGSGRGRTPRHASRAQAPKARRIDSMSRTAYTVGALLLLLGTLLPAAEG KKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIH EEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD >NP_001083746.1 gremlin-1 precursor [Xenopus laevis] MNCLVYALGSLFLLSGLLLPSSEGKKKVSGSQGAIPPPDKGQPNDSEQGQAQPGDRVRGKGKGQALAAEEVLESSQEALH VTERKYLKRDWCKTQPLKQTIHEDGCNSRTIINRFCYGQCNSFYIPRHIRREEGSFQSCSFCKPKKFTTMVVTLNCPELQ PPTKKKRITRVKQCRCISIDLD >XP_004082395.1 gremlin-1-like [Oryzias latipes] MAFSWRIFCGMVFITGLLFSPVDSKRNRGSQGAIPHPDKNNPNESEQQPQPSQAGGSGSRQKPGSSSPADEVLESSQEAL HVTERQYLKRDWCKTQPLKQTIHEEGCISRTIINRFCYGQCNSFYIPRHIRKEEGAFQSCSFCKPKRFTAMTFTLNCPDQ QPPRKRKRIMRVKQCRCISIDLD >XP_038071726.1 gremlin-2-like [Patiria miniata] MMSGVCRHLGTLPCLSGNRVSIPARSMFVCSVLLCLMTTQSLITAASTTGRRLPHTNPLILLDAEEEDSTTSSHRGGSNE RGTGVGGPLAPEEVLTPVGDEPYEVTEKQYLRGDWCKTLPLKQRIDVEGCISRTITNRLCYGQCNSFYIPKQSSDFNDAF RSCSFCKPYRITTFTVSLRCPGQTPSIQRKRVEKVKQCRCVAVDVS >XP_039261207.1 gremlin-1-like [Styela clava] MKSYSGDSCTKRACLHCGQSERSAMENKSAGCREPHPRSNSTTKSPSFIRFGLVALVFISLIILSSVHTTESRRLRKNKN KDAGENDIVVNEEAKASRRRAGKEKGRGKILKTSEKALIITEKRYLKSDWCKSRPLKLVVRSKNGCKGFFINNFCYGQCN SFYIPRNLTPDEKEPAAFKSCSFCKPHIIEKVSVTLTCSRNRGKRGKYIKRIVNKIKECRCIAVPDVESHVAEPSPSTSS TSDSTTSSEPKR >CAE1254612.1 GREM [Sepia pharaonis] MFRRIVFPGAIIAIFFTYLSAQPTISPVPPDELLRPESVAFTVPVNSTPPPTWMPTPGFRSLRSGLVRNGHVKLRRDRER FPLRGTKSAVIFTRKSYLRKEMCKAQSIKQVVKEKGCSRQIVINRFCYGQCNSFYIPRTDKQNIMEPAFKSCSFCSPHRY TWLRVTLRCHNSKSQRFKRIKVKVIKRCKCMAIEANLLS >NP_001256342.1 Bursicon [Caenorhabditis elegans] MNQRCDGQKFKQRIRVDGCLTKVVVNRLCHGACASIFIPRMHSKKLKAAFRSCAACAPAEYDYVDITLDCPGRTPPTATK TIVKVKSCKCKEVRIAPF >XP_031562882.1 gremlin-2-like [Actinia tenebrosa] MLVVPKSKTGIIILLIVMLKASLNNGRSLSQDSLYSTNDLESQGSMRKVPLQNKFPLSPKNHMPSGTSVVVQPSSSSATS QKTHNKKFPLKGGSTLLVLPFLRTAIPKDWCKTRKFLQKIHHHGCNSTYITNNVCVGQCLSVFIPNHFVSCSYCTPVEKN VISVELKCPGLQKPVVKKVSIVKSCRCMPCRKNYPS >XP_030843473.1 gremlin-1-like [Strongylocentrotus purpuratus] MIAAVLWISSLLACALMTSSVPHADVASRVFHHRVSSQGSNDLPTDTQKRHDQDHVTMSPQSDSSDTHYGAHLIDRTVLF PHDTTWCVARPISQVIESPGCTARTIPNKMCAGQCYSFTVPKIFPHDIRSQFKSCDCCQPSRVTWVTIPLSCNAVDGDTV LHKHVEVVEECECKPCSFYTSTSSWSTESTTTNDTEYSDEQSSYVESPSAP
Mafft alignment of selected proteins >sp|O60565|GREM1_HUMAN Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 PE=1 SV=1 ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >sp|O60565-2|GREM1_HUMAN Isoform 2 of Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---- ----------------------------------------------ALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >tr|Q6T937|Q6T937_DANRE Gremlin OS=Danio rerio OX=7955 GN=grem1a PE=2 SV=1 ------------------------------------------------------------ -MTKDALAV----TIVVLWLLCNPARIRG--------------TGGFQGAIPHPNK---Y SPNQSEQSPQ---TPQAG----SR--G-MGPPSAGDEV-LDS-SQEALHVT-ERRYL--- KLDWCKTQPLKLMIYEDGCQPRAIINRFCYGQCNSFYIPR-HI---YQE--DGAFQSCSV CKPKSFTTVTYTLFCP---GQTPNTK-KKRVRRVKQCRCTSV-DLD-------------- -------------------- >NP_035954.1 gremlin-1 precursor [Mus musculus] ------------------------------------------------------------ -MNRTAYTVG--ALLLLLGTLLPTAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PPQPGSRTRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >NP_062155.1 gremlin-1 precursor [Rattus norvegicus] ------------------------------------------------------------ -MNRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PPQPGSRTRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >NP_990309.1 gremlin-1 precursor [Gallus gallus] ------------------------------------------------------------ -MVRTLYAIG--AVFLLTGFLLPTAEGRKR-------------NRGSQGAIPPPDK---D QPNDSEQMQT---QQQSGSRHRER--G-KGTSMPAEEV-LES-SQEALHIT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HV---RKE--EGSFQSCSF CKPKKFTTMTVTLNCP---ELQPPRK-KKRITRVKECRCISI-DLD-------------- -------------------- >XP_523036.4 gremlin-1 [Pan troglodytes] MPG---TRCAFRGPGDPVHGRRVTLGPADPAPSPGGSGRGRT-QRHAS-KAQAPRTRRTD SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_005638258.1 gremlin-1 [Canis lupus familiaris] ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPTAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_024853495.1 gremlin-1 isoform X1 [Bos taurus] MPL---TRCALRGPGDPVCRKSGTLCPADPTRSPGGSGRGRT-PRHAS-RAQAPKARCID SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_020953969.1 gremlin-1 isoform X2 [Sus scrofa] MPC---TRCALRGPGDPVCGESGTLCPAEPAPSPGGSGRGRA-HRHAS-RAQAPKARRTD SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_008267474.1 PREDICTED: gremlin-1 [Oryctolagus cuniculus] MPD---TRCALRGPGDPVHSRSLPLGSADPTPSPGGSGRGRT-QRHAS-RAQAPKPRRPD SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---LQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_002825289.3 gremlin-1 [Pongo abelii] MPG---TRCAFRGPGDPVHGRCVTLGLADPAPSPGGSGRGRT-QRHAS-KAQAPRTRRTD SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_010709901.1 gremlin-1 [Meleagris gallopavo] ------------------------------------------------------------ -MVRTLYAIG--AVFLLMGFLLPTAEGRKR-------------NRGSQGAIPPPDK---D QPNDSEQMQT---QQQSGSRHRER--G-KGTSMPAEEV-LES-SQEALHIT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HV---RKE--EGSFQSCSF CKPKKFTTMTVTLNCP---ELQPPRK-KKRITRVKECRCISI-DLD-------------- -------------------- >XP_017909987.1 PREDICTED: gremlin-1 [Capra hircus] MPL---TRCALRGPGDPVCRKSGPLCPADPTRSPGGSGRGRT-PRHAS-RAQAPKARRVD SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_003805004.2 gremlin-1 [Pan paniscus] ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_011281387.1 gremlin-1 [Felis catus] ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPTAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_012036542.3 gremlin-1 isoform X1 [Ovis aries] ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_030858273.1 gremlin-1 isoform X1 [Gorilla gorilla gorilla] MCL---RRRA--GCGGVLGR---------PLESAGWSIR----------RIHDACICRSP SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_005502506.1 gremlin-1 [Columba livia] ------------------------------------------------------------ -MVRTLYAIG--AVFLLTGFLLLAAEGRKR-------------NRGSQGAIPPPDK---D QPNDSEQMQT---QQQSGSRHRER--G-KGTSMPAEEV-LES-SQEALHIT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HV---RKE--EGSFQSCSF CKPKKFTTMTVTLNCP---ELQPPRK-KKRIT-------YRL-GLS-------------- -------------------- >XP_006018557.1 gremlin-1 [Alligator sinensis] ------------------------------------------------------------ -MGRTVYAVG--ALLLLLGLLFPTGEGRKR-------------NRGSQGAIPPPDK---D QPNDSEQTQT---QQQSGSRNRER--G-KGTSMPAEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HV---HKE--EGSFQSCSF CKPKKFTAMTVTLNCP---ELQPPRK-KKRITRVKECRCISI-DLD-------------- -------------------- >XP_006276353.1 PREDICTED: gremlin-1 [Alligator mississippiensis] ------------------------------------------------------------ -MGRTVYAVG--ALLLLLGVLLPTGEGRKR-------------NRGSQGAIPPPDK---D QPNDSEQTQT---QQQSGSRNRER--G-KGTSVPAEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HV---HKE--EGSFQSCSF CKPKKFTAMTVTLNCP---ELQPPRK-KKRITRVKECRCISI-DLD-------------- -------------------- >XP_015803163.1 PREDICTED: gremlin-1 [Nothobranchius furzeri] M----------------------------------------------------------- -MQPHSLRI----FAAVFAMFHIPPSSAD--------------TGAVQGAFPHPNK---Y NPNESEGCLM---PPIGGLL--SR--GTASATSSTDEV-LES-SQEALLVT-ERRYL--- RLDWCKTQPLKQTIQEEGCLSRTIINRFCYGQCNSFYIPR-HT---HQD--GSVFQSCSA CKPKTFSTVTYTLFCP---GKTPSTR-RKRVQRVKQCRCTTV-KTE-------------- -------------------- >XP_020761931.1 gremlin-1 [Odocoileus virginianus texanus] ------------------------------------------------------------ -MSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_030261039.1 gremlin-1 [Sparus aurata] ------------------------------------------------------------ -MKTPSVLI----STAVLALLLSSPRSTD--------------ADTFQGAIPHPNK---Y DPQEPDRCQQ---PAIGGLI--SR--G-AGPVTSTDEV-LES-SQEALHVT-ERRYL--- RLDWCKTQPLKQTIREEGCLSRTIINRFCYGQCNSFYIPR-HN---YQD--GDVFQSCSA CKPKTFSTVTYTLFCP---GQTPSTR-KKRIQRVKLCRCTTI-DTD-------------- -------------------- >XP_040188088.1 gremlin-1 [Rana temporaria] ------------------------------------------------------------ -MNRLVYTLG--PMFLLFGLLLPNTEGNKK-------------VRGSQGAIPPPDK---G QANDSEQSQT-----HPGNRNGGK--G-KGQALVAEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCIKRTILNRFCYGQCNSFYIPR-HI---RRE--EGSFQSCSF CKPKKFTSMVVTLNCP---ELQPPIK-KKRITRVKQCRCISI-DLD-------------- -------------------- >XP_043776518.1 gremlin-1 isoform X2 [Cervus elaphus] MSD---VSICL-----------------------------------------------SS SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >XP_043327329.1 gremlin-1 isoform X1 [Cervus canadensis] MPL---TRCALRGPGDPVCRKSGALCPADPTRSPRGSGRGRT-PRHAS-RAQAPKARRID SMSRTAYTVG--ALLLLLGTLLPAAEGKK---------------KGSQGAIPPPDK---A QHNDSEQTQS---PQQPGSRNRGRGQG-RGTAMPGEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPR-HI---RKE--EGSFQSCSF CKPKKFTTMMVTLNCP---ELQPPTK-KKRVTRVKQCRCISI-DLD-------------- -------------------- >NP_001083746.1 gremlin-1 precursor [Xenopus laevis] ------------------------------------------------------------ -MNCLVYALG--SLFLLSGLLLPSSEGKKK-------------VSGSQGAIPPPDK---G QPNDSEQGQA-----QPGDRVRGK--G-KGQALAAEEV-LES-SQEALHVT-ERKYL--- KRDWCKTQPLKQTIHEDGCNSRTIINRFCYGQCNSFYIPR-HI---RRE--EGSFQSCSF CKPKKFTTMVVTLNCP---ELQPPTK-KKRITRVKQCRCISI-DLD-------------- -------------------- >XP_004082395.1 gremlin-1-like [Oryzias latipes] ------------------------------------------------------------ -MAFSWRIFC--GMVFITGLLFSPVDSKR--------------NRGSQGAIPHPDK---N NPNESEQQPQ---PSQAGGSGSRQ--K-PGSSSPADEV-LES-SQEALHVT-ERQYL--- KRDWCKTQPLKQTIHEEGCISRTIINRFCYGQCNSFYIPR-HI---RKE--EGAFQSCSF CKPKRFTAMTFTLNCP---DQQPPRK-RKRIMRVKQCRCISI-DLD-------------- -------------------- >XP_038071726.1 gremlin-2-like [Patiria miniata] MMS---GVC-----------------------------------RHLG-TLPCLSGNRV- SIPARSMFV----CSVLLCLMTTQSLITA--------------ASTTGRRLPHTNPLILL DAEEEDSTTS---SHRGGSNERGT--G-VGGPLAPEEV-LTPVGDEPYEVT-EKQYL--- RGDWCKTLPLKQRIDVEGCISRTITNRLCYGQCNSFYIPK-QS---SDF--NDAFRSCSF CKPYRITTFTVSLRCP---GQTPSIQ-RKRVEKVKQCRCVAV-DVS-------------- -------------------- >XP_039261207.1 gremlin-1-like [Styela clava] MKSYSGDSCTKRA-----------------CLHCGQSERSAMENKSAGCREPHPRSNST- TKSPSFIRFGLVALVFISLIILSSVHTTE-----------------SRRLRKNKNK---D AGENDIVVNE---EAKAS----RR--R-AGKEKGRGKI-LKT-SEKALIIT-EKRYL--- KSDWCKSRPLKLVVRSKNGCKGFFINNFCYGQCNSFYIPR-NLTPDEKE--PAAFKSCSF CKPHIIEKVSVTLTCSRNRGKRGKYI-KRIVNKIKECRCIAVPDVESHVAEPSPSTSSTS DSTTSSE----------PKR >CAE1254612.1 GREM [Sepia pharaonis] ------------------------------------------------------------ -MFRRIVFPG--AIIAIFFTYLSAQPTISPVPPDEL-------LRPESVAFTVPVN---S TPPPTWMPTPGFRSLRSGLV--RN--GHVKLRRDRERFPLRG-TKSAVIFT-RKSYL--- RKEMCKAQSIKQVVKEKGCSRQIVINRFCYGQCNSFYIPR-TD---KQNIMEPAFKSCSF CSPHRYTWLRVTLRCH---NSKSQRFKRIKVKVIKRCKCMAI-EAN-------------- --LLS--------------- >NP_001256342.1 Bursicon [Caenorhabditis elegans] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MNQRCDGQKFKQRIRVDGCLTKVVVNRLCHGACASIFIPRMHS---KKL--KAAFRSCAA CAPAEYDYVDITLDCP---GRTPPTA-TKTIVKVKSCKCKEV-RIA-------------- -----------------PF- >XP_031562882.1 gremlin-2-like [Actinia tenebrosa] M----------------------------------------------------------- -LVVPKSKTG--IIILLIVMLKASLNNGRSLSQDSLYSTNDLESQGSMRKVPLQNKFPLS PKNHMPSGTSVVVQPSSSSA--------TSQKTHNKKFPLKG-GSTLLVLPFLRTAI--- PKDWCKTRKFLQKIHHHGCNSTYITNNVCVGQCLSVFIPN-H------------FVSCSY CTPVEKNVISVELKCP---GLQKPVV-KK-VSIVKSCRCMPC-RKN-------------- --YPS--------------- >XP_030843473.1 gremlin-1-like [Strongylocentrotus purpuratus] ------------------------------------------------------------ -------MIA--AVLWISSLLACALMTSSV-PH----------ADVASRVFHHRVS---S QGSNDLPTDT---QKRHDQ---------DHVTMSPQSD-SSD-THYGAHLI-DRTVLFPH DTTWCVARPISQVIESPGCTARTIPNKMCAGQCYSFTVPK-IF---PHDI-RSQFKSCDC CQPSRVTWVTIPLSCN---AVDGDTVLHKHVEVVEECECKPCSFYTSTSSWSTEST-TTN DTEYSDEQSSYVESPSAP--
BMGE Cleaned alignment of selected proteins >sp|O60565|GREM1_HUMAN Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 PE=1 SV=1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >sp|O60565-2|GREM1_HUMAN Isoform 2 of Gremlin-1 OS=Homo sapiens OX=9606 GN=GREM1 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-----------------------------------ALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >tr|Q6T937|Q6T937_DANRE Gremlin OS=Danio rerio OX=7955 GN=grem1a PE=2 SV=1 MTKDALAV--TIVVLWLLCNPARIRGGGFQGAIPHPNKYSPNQSEQSPQTPQAG----SRMGPPSAGDEVSQEALHVTERRYLKLDWCKTQPLKLMIYEDGCQPRAIINRFCYGQCNSFYIPRDGAFQSCSVCKPKSFTTVTYTLFCPGQTPNTKKKRVRRVKQCRCTSV >NP_035954.1 gremlin-1 precursor [Mus musculus] MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >NP_062155.1 gremlin-1 precursor [Rattus norvegicus] MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >NP_990309.1 gremlin-1 precursor [Gallus gallus] MVRTLYAIGAVFLLTGFLLPTAEGRKRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERKGTSMPAEEVSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISI >XP_523036.4 gremlin-1 [Pan troglodytes] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_005638258.1 gremlin-1 [Canis lupus familiaris] MSRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_024853495.1 gremlin-1 isoform X1 [Bos taurus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_020953969.1 gremlin-1 isoform X2 [Sus scrofa] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_008267474.1 PREDICTED: gremlin-1 [Oryctolagus cuniculus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSLQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_002825289.3 gremlin-1 [Pongo abelii] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_010709901.1 gremlin-1 [Meleagris gallopavo] MVRTLYAIGAVFLLMGFLLPTAEGRKRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERKGTSMPAEEVSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMTVTLNCPELQPPRKKKRITRVKECRCISI >XP_017909987.1 PREDICTED: gremlin-1 [Capra hircus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_003805004.2 gremlin-1 [Pan paniscus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_011281387.1 gremlin-1 [Felis catus] MSRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_012036542.3 gremlin-1 isoform X1 [Ovis aries] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_030858273.1 gremlin-1 isoform X1 [Gorilla gorilla gorilla] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_005502506.1 gremlin-1 [Columba livia] MVRTLYAIGAVFLLTGFLLLAAEGRKRGSQGAIPPPDKDQPNDSEQMQTQQQSGSRHRERKGTSMPAEEVSQEALHITERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMTVTLNCPELQPPRKKKRIT-------YRL >XP_006018557.1 gremlin-1 [Alligator sinensis] MGRTVYAVGALLLLLGLLFPTGEGRKRGSQGAIPPPDKDQPNDSEQTQTQQQSGSRNRERKGTSMPAEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTAMTVTLNCPELQPPRKKKRITRVKECRCISI >XP_006276353.1 PREDICTED: gremlin-1 [Alligator mississippiensis] MGRTVYAVGALLLLLGVLLPTGEGRKRGSQGAIPPPDKDQPNDSEQTQTQQQSGSRNRERKGTSVPAEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTAMTVTLNCPELQPPRKKKRITRVKECRCISI >XP_015803163.1 PREDICTED: gremlin-1 [Nothobranchius furzeri] MQPHSLRI--FAAVFAMFHIPPSSADGAVQGAFPHPNKYNPNESEGCLMPPIGGLL--SRASATSSTDEVSQEALLVTERRYLRLDWCKTQPLKQTIQEEGCLSRTIINRFCYGQCNSFYIPRGSVFQSCSACKPKTFSTVTYTLFCPGKTPSTRRKRVQRVKQCRCTTV >XP_020761931.1 gremlin-1 [Odocoileus virginianus texanus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_030261039.1 gremlin-1 [Sparus aurata] MKTPSVLI--STAVLALLLSSPRSTDDTFQGAIPHPNKYDPQEPDRCQQPAIGGLI--SRAGPVTSTDEVSQEALHVTERRYLRLDWCKTQPLKQTIREEGCLSRTIINRFCYGQCNSFYIPRGDVFQSCSACKPKTFSTVTYTLFCPGQTPSTRKKRIQRVKLCRCTTI >XP_040188088.1 gremlin-1 [Rana temporaria] MNRLVYTLGPMFLLFGLLLPNTEGNKRGSQGAIPPPDKGQANDSEQSQT--HPGNRNGGKKGQALVAEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCIKRTILNRFCYGQCNSFYIPREGSFQSCSFCKPKKFTSMVVTLNCPELQPPIKKKRITRVKQCRCISI >XP_043776518.1 gremlin-1 isoform X2 [Cervus elaphus] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >XP_043327329.1 gremlin-1 isoform X1 [Cervus canadensis] MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRRGTAMPGEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISI >NP_001083746.1 gremlin-1 precursor [Xenopus laevis] MNCLVYALGSLFLLSGLLLPSSEGKKSGSQGAIPPPDKGQPNDSEQGQA--QPGDRVRGKKGQALAAEEVSQEALHVTERKYLKRDWCKTQPLKQTIHEDGCNSRTIINRFCYGQCNSFYIPREGSFQSCSFCKPKKFTTMVVTLNCPELQPPTKKKRITRVKQCRCISI >XP_004082395.1 gremlin-1-like [Oryzias latipes] MAFSWRIFCGMVFITGLLFSPVDSKRRGSQGAIPHPDKNNPNESEQQPQPSQAGGSGSRQPGSSSPADEVSQEALHVTERQYLKRDWCKTQPLKQTIHEEGCISRTIINRFCYGQCNSFYIPREGAFQSCSFCKPKRFTAMTFTLNCPDQQPPRKRKRIMRVKQCRCISI >XP_038071726.1 gremlin-2-like [Patiria miniata] IPARSMFV--CSVLLCLMTTQSLITASTTGRRLPHTNPLDAEEEDSTTSSHRGGSNERGTVGGPLAPEEVGDEPYEVTEKQYLRGDWCKTLPLKQRIDVEGCISRTITNRLCYGQCNSFYIPKNDAFRSCSFCKPYRITTFTVSLRCPGQTPSIQRKRVEKVKQCRCVAV >XP_039261207.1 gremlin-1-like [Styela clava] KSPSFIRFGALVFISLIILSSVHTTE--SRRLRKNKNKDAGENDIVVNEEAKAS----RRAGKEKGRGKISEKALIITEKRYLKSDWCKSRPLKLVVRSKNGCKGFFINNFCYGQCNSFYIPRPAAFKSCSFCKPHIIEKVSVTLTCSGKRGKYIKRIVNKIKECRCIAV >CAE1254612.1 GREM [Sepia pharaonis] MFRRIVFPGAIIAIFFTYLSAQPTISRPESVAFTVPVNSTPPPTWMPTPSLRSGLV--RNVKLRRDRERFTKSAVIFTRKSYLRKEMCKAQSIKQVVKEKGCSRQIVINRFCYGQCNSFYIPREPAFKSCSFCSPHRYTWLRVTLRCHNSKSQRFRIKVKVIKRCKCMAI >NP_001256342.1 Bursicon [Caenorhabditis elegans] -----------------------------------------------------------------------------------MNQRCDGQKFKQRIRVDGCLTKVVVNRLCHGACASIFIPRKAAFRSCAACAPAEYDYVDITLDCPGRTPPTATKTIVKVKSCKCKEV >XP_031562882.1 gremlin-2-like [Actinia tenebrosa] LVVPKSKTGIIILLIVMLKASLNNGRQGSMRKVPLQNKSPKNHMPSGTSQPSSSSA----TSQKTHNKKFGSTLLVLPLRTAIPKDWCKTRKFLQKIHHHGCNSTYITNNVCVGQCLSVFIPN---FVSCSYCTPVEKNVISVELKCPGLQKPVVKK-VSIVKSCRCMPC >XP_030843473.1 gremlin-1-like [Strongylocentrotus purpuratus] ------MIAAVLWISSLLACALMTSSDVASRVFHHRVSSQGSNDLPTDTQKRHDQ-----DHVTMSPQSDTHYGAHLIDRTVLDTTWCVARPISQVIESPGCTARTIPNKMCAGQCYSFTVPKRSQFKSCDCCQPSRVTWVTIPLSCNAVDGDTVHKHVEVVEECECKPC
PhyML tree of selected proteins (NP_001256342_1_Bursicon__Caenorhabditis_elegans_:2.15267085,XP_031562882_1_gremlin_2_like__Actinia_tenebrosa_:2.60604181,(XP_038071726_1_gremlin_2_like__Patiria_miniata_:0.93701069,(((tr_Q6T937_Q6T937_DANRE_Gremlin_OS_Danio_rerio_OX_7955_GN_grem1a_PE_2_SV_1:0.24251055,(XP_015803163_1_PREDICTED__gremlin_1__Nothobranchius_furzeri_:0.21905083,XP_030261039_1_gremlin_1__Sparus_aurata_:0.15816477):0.27707664):0.24994432,(XP_004082395_1_gremlin_1_like__Oryzias_latipes_:0.22025485,((((XP_005638258_1_gremlin_1__Canis_lupus_familiaris_:0.00000001,XP_011281387_1_gremlin_1__Felis_catus_:0.00000001):0.00000001,((sp_O60565_2_GREM1_HUMAN_Isoform_2_of_Gremlin_1_OS_Homo_sapiens_OX_9606_GN_GREM1:0.00000001,(NP_062155_1_gremlin_1_precursor__Rattus_norvegicus_:0.00000001,NP_035954_1_gremlin_1_precursor__Mus_musculus_:0.00648662):0.01959302):0.00000001,((XP_043776518_1_gremlin_1_isoform_X2__Cervus_elaphus_:0.00000001,(XP_020761931_1_gremlin_1__Odocoileus_virginianus_texanus_:0.00000001,(XP_030858273_1_gremlin_1_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001,(XP_012036542_3_gremlin_1_isoform_X1__Ovis_aries_:0.00000001,(XP_003805004_2_gremlin_1__Pan_paniscus_:0.00000001,(XP_017909987_1_PREDICTED__gremlin_1__Capra_hircus_:0.00000001,(XP_002825289_3_gremlin_1__Pongo_abelii_:0.00000001,(XP_020953969_1_gremlin_1_isoform_X2__Sus_scrofa_:0.00000001,(XP_024853495_1_gremlin_1_isoform_X1__Bos_taurus_:0.00000001,(XP_523036_4_gremlin_1__Pan_troglodytes_:0.00000001,(sp_O60565_GREM1_HUMAN_Gremlin_1_OS_Homo_sapiens_OX_9606_GN_GREM1_PE_1_SV_1:0.00000001,XP_043327329_1_gremlin_1_isoform_X1__Cervus_canadensis_:0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001):0.00000001,XP_008267474_1_PREDICTED__gremlin_1__Oryctolagus_cuniculus_:0.00634868):0.00000001):0.00638658):0.07199955,(XP_040188088_1_gremlin_1__Rana_temporaria_:0.1158209,NP_001083746_1_gremlin_1_precursor__Xenopus_laevis_:0.07395263):0.10662671):0.03174686,((XP_010709901_1_gremlin_1__Meleagris_gallopavo_:0.00000001,(XP_005502506_1_gremlin_1__Columba_livia_:0.0326396,NP_990309_1_gremlin_1_precursor__Gallus_gallus_:0.00000001):0.00621053):0.06715189,(XP_006276353_1_PREDICTED__gremlin_1__Alligator_mississippiensis_:0.01335806,XP_006018557_1_gremlin_1__Alligator_sinensis_:0.00630418):0.01840767):0.0377102):0.29209607):0.17706178):0.18332808,(XP_039261207_1_gremlin_1_like__Styela_clava_:1.4634094,(CAE1254612_1_GREM__Sepia_pharaonis_:1.41874471,XP_030843473_1_gremlin_1_like__Strongylocentrotus_purpuratus_:3.58940511):0.5266704):0.59739956):0.2781199):0.83922514);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)