PB0212

DATABASE

Click here to access PB0212 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0212	P02753	Retinol-binding protein 4	RBP4	MCOPCB10, RDCCAS	Homo_sapiens	Delivers retinol from the liver stores to the peripheral tissues (Probable). Transfers the bound all-trans retinol to STRA6, that then facilitates retinol transport across the cell membrane (PubMed:22665496).

Domains

Gene Ontology

PF00061 (Lipocalin)

GO:0005501 (enables) retinoid binding GO:0005515 (enables) protein binding GO:0016918 (enables) retinal binding GO:0019841 (enables) retinol binding GO:0034632 (enables) retinol transmembrane transporter activity GO:0001654 (involved in) eye development GO:0002639 (involved in) positive regulation of immunoglobulin production GO:0006094 (involved in) gluconeogenesis GO:0007507 (involved in) heart development GO:0007601 (involved in) visual perception GO:0030277 (involved in) maintenance of gastrointestinal epithelium GO:0030324 (involved in) lung development GO:0032024 (involved in) positive regulation of insulin secretion GO:0032526 (involved in) response to retinoic acid GO:0034633 (involved in) retinol transport GO:0042572 (involved in) retinol metabolic process GO:0042593 (involved in) glucose homeostasis GO:0048562 (involved in) embryonic organ morphogenesis GO:0048706 (involved in) embryonic skeletal system development GO:0048738 (involved in) cardiac muscle tissue development GO:0048807 (involved in) female genitalia morphogenesis GO:0050896 (involved in) response to stimulus GO:0060044 (involved in) negative regulation of cardiac muscle cell proliferation GO:0060059 (involved in) embryonic retina morphogenesis in camera-type eye GO:0060065 (involved in) uterus development GO:0060068 (involved in) vagina development GO:0060157 (involved in) urinary bladder development GO:0060347 (involved in) heart trabecula formation GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P02753|RET4_HUMAN Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3 MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA RQYRLIVHNGYCDGRSERNLL >tr|Q6PC07|Q6PC07_DANRE Purpurin OS=Danio rerio OX=7955 GN=rbp4l PE=1 SV=1 MGFYKFALLVVFLSYIERCFSASCAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDN ISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSVPDPTTPAKMFMNYQGLASYLS SGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDE ICMAGQFQPVLQSGAC
Selected proteins from model organisms >sp|P02753|RET4_HUMAN Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3 MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIV AEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGND DHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLA RQYRLIVHNGYCDGRSERNLL >tr|Q6PC07|Q6PC07_DANRE Purpurin OS=Danio rerio OX=7955 GN=rbp4l PE=1 SV=1 MGFYKFALLVVFLSYIERCFSASCAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDN ISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSVPDPTTPAKMFMNYQGLASYLS SGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDE ICMAGQFQPVLQSGAC >NP_035385.1 retinol-binding protein 4 isoform 2 precursor [Mus musculus] MEWVWALVLLAALGGGSAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGH MSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRL QNLDGTCADSYSFVFSRDPNGLSPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL >NP_037294.1 retinol-binding protein 4 precursor [Rattus norvegicus] MEWVWALVLLAALGGGSAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGH MSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRL QNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL >NP_001035565.2 retinol-binding protein 4 precursor [Bos taurus] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETFAVQYSCRL LNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL >XP_025007256.1 retinol-binding protein 4 isoform X1 [Gallus gallus] MQDRMAYTWRALLLLALAFLGSSMAERDCRVSSFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQF TVDENGQMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYA LHYSCRELNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS >NP_999222.1 retinol-binding protein 4 precursor [Sus scrofa] MEWVWALVLLAALGSAQAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAAQYSCRL QNLDGTCADSYSFVFARDPHGFSPEVQKIVRQRQEELCLARQYRLITHNGYCDGKSERNIL >NP_001038960.1 retinol-binding protein 4 precursor [Pan troglodytes] MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_534969.3 retinol-binding protein 4 [Canis lupus familiaris] MEWVWALVLLAALGSARAESDCRVSNFQVKKNFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGR MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPLEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSEPNTL >NP_001075790.1 retinol-binding protein 4 precursor [Oryctolagus cuniculus] MEWVWALVLLAALGSGRGERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFAVQYSCRL LNFDGTCADSYSFVFSRDPHGLPPDVQKLVRQRQEELCLSRQYRLIVHNGYCDDKSVRNLL >XP_002821040.1 retinol-binding protein 4 isoform X1 [Pongo abelii] MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_003208093.1 retinol-binding protein 4 [Meleagris gallopavo] MAYTRRSLLLLALAFLGSSMAERDCRVSNFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDE NGQMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYS CRELNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS >XP_008948942.1 retinol-binding protein 4 [Pan paniscus] MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >NP_001277178.1 retinol binding protein 4 precursor [Felis catus] MAWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRL LNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELCLARQYRLIVHNGYCDGKSEQNIL >XP_027815955.1 retinol-binding protein 4 [Ovis aries] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRL LNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL >XP_018890983.2 retinol-binding protein 4 [Gorilla gorilla gorilla] MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQ MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRL LNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_004080296.1 retinol-binding protein 4 [Oryzias latipes] MLRYVVALCFLASSVFSTELEPLENNCQIANFQVKQDFDRTRYAGVWYAVGKKDPEGLFLLDNVVAEFKV EDDGRMTATAKGRVIILNNWEMCAHMFATFEDTPEPAKFRMKYWGAASYLQTGNDEHWVIDTDYDNYAIH YSCRLLDSDGTCLDSYSFVFSRHPTGLRAEDQAIITQKKNDICLLGKYRRVAHNGFCDNTADLSQQ >XP_005507020.2 retinol-binding protein 4 isoform X1 [Columba livia] MGQGQRPPEPTGVTQKAVVKQPQPAACTNPPSYAPSNAGFVPRGVAKASGLHKALPVWLPYHCTQTDTWA PRGYRDQHCLDRMAHTERALSYLLLLALALLGSSTAERDCRVSSFKVKENFDKSRYSGIWYAMAKKDPEG LFLQDNVVAEFTVDENGQMTATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDH WVVDTDYDTYALHYSCRQLNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQVDLCLERKYRVIVHNGFC S >XP_017896583.1 PREDICTED: retinol-binding protein 4 isoform X1 [Capra hircus] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRL LNLDGTCADSYSFVFARDPSGFAPEVQKIVRQRQEELCLARQYRLIPHKVTVMASQKETFCSNMEGVLSL GNFPLTLLSLQLFGV >XP_006259744.1 PREDICTED: retinol-binding protein 4 [Alligator mississippiensis] MAGARTALAGLLLLVLLAPLPRGGRAERDCRVSGFRVQDNFDKARYSGIWYAMAKKDPEGLFLQDNVVAE FSVDEYGQMSATAKGRVRLFNNWDICADMIGSFTDTEDPAKFKMKYWGVAAYLQRGNDDHWIVDTDYDTY AIHYSCRELNDDGTCADSYSFVFSRDINGLSPEAQRIVRQRQVELCLDRKYRLIVHNGYCS >XP_015818632.1 PREDICTED: retinol-binding protein 4 [Nothobranchius furzeri] MLRYFVVLCLLALSWANDCQVANFQVKQDFDKTRYAGTWYAVGKKDPEGLFLLDNVVAEFTVDEEGKMTA TAKGRVIILNNWEMCAHMFATFEETPEPAKLKMKYWGAASYLQTGNDEHWVIDTDYDNYAIHYSCRALDT TGTCLDSYSFVFSRHSAGLRPEDQAIITQRKTELCLLGKYRRVEHNGFCDVPQ >XP_020764164.1 retinol-binding protein 4 [Odocoileus virginianus texanus] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGH MSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRL LNLDGTCADSYSFVFARDPSGFSPEVQRIVRQRQEELCLARQYRLIPHNGYCDGRSERNTL >XP_030256003.1 retinol-binding protein 4 isoform X1 [Sparus aurata] MTSRMLRYVVALCLLAVSWAQDCQVANIQVMQNFDKTRYAGTWYAVGKKDPEGLFLIDNIVAQFTIHEDG AMTATAKGRVIILNNWEMCADMMATFETTPDPAKFRMRYWGAASYLQTGNDDHWVIATDYDNYAIHYSCR VVDSDGTCLDSYSFVFSRHATGLRQEDVEIIVQKKTELCLLHKYRRVAHTGFCDSS >XP_040217704.1 retinol-binding protein 4 [Rana temporaria] MDLKIFGLFIALFCLSSAERDCRVSTFKTMETFDRQRYAGTWYAVAKKDPEGLFLYDDIVAHFSIDEEGK MTATARGRVFLMGTIEVCADMVGLFQDTDDPAKFVMKYYGLASYLEKGVDNHWVVDTDYDNYAIVYSCRE MGDNGDCLDDYSFIFSRNQNGLTPEAQRNVRRKQSELCLDRKYRIVPQNGVCNQIY >XP_043332130.1 retinol-binding protein 4 [Cervus canadensis] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVR LLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPS GFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNTL >KAB0346979.1 hypothetical protein FD754_011836 [Muntiacus muntjak] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVR LLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPS GFSPEVQRIVRQRQEELCLARQYRLIPHNGKFKTERTLLYTADPLLSAYTPFAPQRNQRVQKTSKMFMYYNYI >KAB0384699.1 hypothetical protein FD755_006616 [Muntiacus reevesi] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVR LLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPS GFSPEVQRIVRQRQEELCLARQYRLIPHNGHSEQSIKLLKE >KAF4019100.1 hypothetical protein G4228_010897 [Cervus hanglu yarkandensis] MEWVWALVLLAALGSARAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVR LLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPS GFSPEVQKIVRQRQEELCLARQYRLIPHNGEWRVGAGSLGLQALRCVTSACRRKQGSLGAHLSPSLRPS >NP_001081195.1 retinol-binding protein 4 precursor [Xenopus laevis] MERKVLGLLIALGFLGSCLAEKNCRVDNFEVMKDFNKERYAGVWYAVAKKDPEGLFLLDNIVANFKIEDNGKMTATAKGR VRILDKLELCANMVGTFIETNDPAKYRMKYHGALAILERGLDDHWVVDTDYTTYAITYACRRRNLDGTCRDSYSFVFSRD INGLPSESQRIVRRRQEQLCLDRKYRVVVHNGYCETN >XP_030854074.1 uncharacterized protein LOC115929361 isoform X2 [Strongylocentrotus purpuratus] MEFVAEAHVPEGSTTPSKLLLQPRGVPVPAEDYWVIYTDYVDHALVYSCSQRNEDGTCPEDRARVWFLGRAGTLSVDARH HMESLLSGLCVEVSRMQDISTGCDAELGVPTSVEAMPHAHGGMVSSTCLVNDIHTMANFDKNQYTGTWYVISHLQGDIYP YHRISHYTLDEQNSFRMLTHRITSPGECSTAWKFEGQAYNPDTSETTSKLVLKPFGMPVYGEDYWVIYTDYTDHALIYSC RETNEDGTCKAEASHAWMMSRDPTLTPAARSHMEMLLTEMCVDVSRLVDTPHECDELLGPESLIDQGRIIAPLHVFLWRN VLKVLSL
Mafft alignment of selected proteins >sp|P02753|RET4_HUMAN Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3 ------------------------------------------------------------ ----------------------MKWVWA-------------------------------- -----------------------------------------------LLLL--------- ------AALG-SGR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL-------------------- -------------- >tr|Q6PC07|Q6PC07_DANRE Purpurin OS=Danio rerio OX=7955 GN=rbp4l PE=1 SV=1 ------------------------------------------------------------ ----------------------MGFYKFAL------------------------------ ----------------------------------------------LVVFL--------- ------SYIE-RC--------------FSASCAVESFTVKDDFDPKRYAGKWYAQQKKDP EGLFLQDNISAEYTIDDDGTMTA-----SSKGRVTLFGFWVVCADMAAQYSVPDPTTPAK MFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKDDGSCD--DGYSLVFSRNPRG LPPAIQRLVRQKQDEICMAGQFQPVLQSGAC----------------------------- -------------- >NP_035385.1 retinol-binding protein 4 isoform 2 precursor [Mus musculus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-GGS-------------AERDCRVSSFRVKENFDKARFSGLWYAIAKKDP EGLFLQDNIIAEFSVDEKGHMSA-----TAKGRVRLLSNWEVCADMVGTFT--DTEDPAK FKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCA--DSYSFVFSRDPNG LSPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL-------------------- -------------- >NP_037294.1 retinol-binding protein 4 precursor [Rattus norvegicus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-GGS-------------AERDCRVSSFRVKENFDKARFSGLWYAIAKKDP EGLFLQDNIIAEFSVDEKGHMSA-----TAKGRVRLLSNWEVCADMVGTFT--DTEDPAK FKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCA--DSYSFVFSRDPNG LTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL-------------------- -------------- >NP_001035565.2 retinol-binding protein 4 precursor [Bos taurus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETFAVQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL-------------------- -------------- >XP_025007256.1 retinol-binding protein 4 isoform X1 [Gallus gallus] MQ---------------------------------------------------------- --------------------DRMAYTWRA------------------------------- -----------------------------------L----------LLLAL--------- ------AFLG-SSM-------------AERDCRVSSFKVKENFDKNRYSGTWYAMAKKDP EGLFLQDNVVAQFTVDENGQMSA-----TAKGRVRLFNNWDVCADMIGSFT--DTEDPAK FKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNEDGTCA--DSYSFVFSRDPKG LPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS---------------------------- -------------- >NP_999222.1 retinol-binding protein 4 precursor [Sus scrofa] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAQ-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYDTYAAQYSCRLQNLDGTCA--DSYSFVFARDPHG FSPEVQKIVRQRQEELCLARQYRLITHNGYCDGKSERNIL-------------------- -------------- >NP_001038960.1 retinol-binding protein 4 precursor [Pan troglodytes] ------------------------------------------------------------ ----------------------MKWVWA-------------------------------- -----------------------------------------------LLLL--------- ------AALG-SGR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL-------------------- -------------- >XP_534969.3 retinol-binding protein 4 [Canis lupus familiaris] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AESDCRVSNFQVKKNFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGRMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPLEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSEPNTL-------------------- -------------- >NP_001075790.1 retinol-binding protein 4 precursor [Oryctolagus cuniculus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SGR-------------GERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQRGNDDHWIIDTDYDTFAVQYSCRLLNFDGTCA--DSYSFVFSRDPHG LPPDVQKLVRQRQEELCLSRQYRLIVHNGYCDDKSVRNLL-------------------- -------------- >XP_002821040.1 retinol-binding protein 4 isoform X1 [Pongo abelii] ------------------------------------------------------------ ----------------------MKWVWA-------------------------------- -----------------------------------------------LLLL--------- ------AALG-SGR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL-------------------- -------------- >XP_003208093.1 retinol-binding protein 4 [Meleagris gallopavo] ------------------------------------------------------------ ----------------------MAYTRRS------------------------------- -----------------------------------L----------LLLAL--------- ------AFLG-SSM-------------AERDCRVSNFKVKENFDKNRYSGTWYAMAKKDP EGLFLQDNVVAQFTVDENGQMSA-----TAKGRVRLFNNWDVCADMIGSFT--DTEDPAK FKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNEDGTCA--DSYSFVFSRDPKG LPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS---------------------------- -------------- >XP_008948942.1 retinol-binding protein 4 [Pan paniscus] ------------------------------------------------------------ ----------------------MKWVWA-------------------------------- -----------------------------------------------LLLL--------- ------AALG-SGR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL-------------------- -------------- >NP_001277178.1 retinol binding protein 4 precursor [Felis catus] ------------------------------------------------------------ ----------------------MAWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDENGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDSAK FKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFARDPNG LPPDVQKIVRQRQDELCLARQYRLIVHNGYCDGKSEQNIL-------------------- -------------- >XP_027815955.1 retinol-binding protein 4 [Ovis aries] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL-------------------- -------------- >XP_018890983.2 retinol-binding protein 4 [Gorilla gorilla gorilla] ------------------------------------------------------------ ----------------------MKWVWA-------------------------------- -----------------------------------------------LLLL--------- ------AALG-SGR-------------AERDCRVSSFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCA--DSYSFVFSRDPNG LPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL-------------------- -------------- >XP_004080296.1 retinol-binding protein 4 [Oryzias latipes] ------------------------------------------------------------ ----------------------------MLR----------------------------- ----------------------------------------------YVVAL--------- ------CFLA-SSVFSTELEP------LENNCQIANFQVKQDFDRTRYAGVWYAVGKKDP EGLFLLDNVVAEFKVEDDGRMTA-----TAKGRVIILNNWEMCAHMFATFE--DTPEPAK FRMKYWGAASYLQTGNDEHWVIDTDYDNYAIHYSCRLLDSDGTCL--DSYSFVFSRHPTG LRAEDQAIITQKKNDICLLGKYRRVAHNGFCDNTADLSQQ-------------------- -------------- >XP_005507020.2 retinol-binding protein 4 isoform X1 [Columba livia] MGQGQRPPEPTGVTQKAVVKQPQPAACTNPPSYAPSNAGFVPRGVAKASGLHKALPVWLP YHCTQTDTWAPRGYRDQHCLDRMAHTERALS----------------------------- ---------------------------------Y-L----------LLLAL--------- ------ALLG-SST-------------AERDCRVSSFKVKENFDKSRYSGIWYAMAKKDP EGLFLQDNVVAEFTVDENGQMTA-----TAKGRVRLFNNWDVCADMIGSFT--DTEDPAK FKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRQLNEDGTCA--DSYSFVFSRDPKG LPPEAQKIVRQRQVDLCLERKYRVIVHNGFCS---------------------------- -------------- >XP_017896583.1 PREDICTED: retinol-binding protein 4 isoform X1 [Capra hircus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRLLNLDGTCA--DSYSFVFARDPSG FAPEVQKIVRQRQEELCLARQYRLIPHKVTV--MASQKETFCSN----MEGVLSLGNFPL TLLSLQLFGV---- >XP_006259744.1 PREDICTED: retinol-binding protein 4 [Alligator mississippiensis] ------------------------------------------------------------ ----------------------MAGARTALA----------------------------- ---------------------------------GLL----------LLVLL--------- ------APLPRGGR-------------AERDCRVSGFRVQDNFDKARYSGIWYAMAKKDP EGLFLQDNVVAEFSVDEYGQMSA-----TAKGRVRLFNNWDICADMIGSFT--DTEDPAK FKMKYWGVAAYLQRGNDDHWIVDTDYDTYAIHYSCRELNDDGTCA--DSYSFVFSRDING LSPEAQRIVRQRQVELCLDRKYRLIVHNGYCS---------------------------- -------------- >XP_015818632.1 PREDICTED: retinol-binding protein 4 [Nothobranchius furzeri] ------------------------------------------------------------ ----------------------------MLR----------------------------- ----------------------------------------------YFVVL--------- ------CLLA-LS--------------WANDCQVANFQVKQDFDKTRYAGTWYAVGKKDP EGLFLLDNVVAEFTVDEEGKMTA-----TAKGRVIILNNWEMCAHMFATFE--ETPEPAK LKMKYWGAASYLQTGNDEHWVIDTDYDNYAIHYSCRALDTTGTCL--DSYSFVFSRHSAG LRPEDQAIITQRKTELCLLGKYRRVEHNGFCDVPQ------------------------- -------------- >XP_020764164.1 retinol-binding protein 4 [Odocoileus virginianus texanus] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQRIVRQRQEELCLARQYRLIPHNGYCDGRSERNTL-------------------- -------------- >XP_030256003.1 retinol-binding protein 4 isoform X1 [Sparus aurata] ------------------------------------------------------------ ----------------------MT--SRMLR----------------------------- ----------------------------------------------YVVAL--------- ------CLLA-VS--------------WAQDCQVANIQVMQNFDKTRYAGTWYAVGKKDP EGLFLIDNIVAQFTIHEDGAMTA-----TAKGRVIILNNWEMCADMMATFE--TTPDPAK FRMRYWGAASYLQTGNDDHWVIATDYDNYAIHYSCRVVDSDGTCL--DSYSFVFSRHATG LRQEDVEIIVQKKTELCLLHKYRRVAHTGFCDSS-------------------------- -------------- >XP_040217704.1 retinol-binding protein 4 [Rana temporaria] ------------------------------------------------------------ ----------------------MD--LKIFG----------------------------- ------------------------------------------------LFI--------- ------ALFC-LSS-------------AERDCRVSTFKTMETFDRQRYAGTWYAVAKKDP EGLFLYDDIVAHFSIDEEGKMTA-----TARGRVFLMGTIEVCADMVGLFQ--DTDDPAK FVMKYYGLASYLEKGVDNHWVVDTDYDNYAIVYSCREMGDNGDCL--DDYSFIFSRNQNG LTPEAQRNVRRKQSELCLDRKYRIVPQNGVCNQIY------------------------- -------------- >XP_043332130.1 retinol-binding protein 4 [Cervus canadensis] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNTL-------------------- -------------- >KAB0346979.1 hypothetical protein FD754_011836 [Muntiacus muntjak] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQRIVRQRQEELCLARQYRLIPHNGKF--KTERTLLYTADPLLSAYTPFAPQRNQR VQKTSKMFMYYNYI >KAB0384699.1 hypothetical protein FD755_006616 [Muntiacus reevesi] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQRIVRQRQEELCLARQYRLIPHNGHS--EQSIKLLKE------------------ -------------- >KAF4019100.1 hypothetical protein G4228_010897 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ----------------------MEWVWA-------------------------------- -----------------------------------------------LVLL--------- ------AALG-SAR-------------AERDCRVSSFRVKENFDKARFAGTWYAMAKKDP EGLFLQDNIVAEFSVDENGHMSA-----TAKGRVRLLNNWDVCADMVGTFT--DTEDPAK FKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCA--DSYSFVFARDPSG FSPEVQKIVRQRQEELCLARQYRLIPHNGEW--RVGAGSL----GLQALRCVTSACRRKQ GSLGAHLSPSLRPS >NP_001081195.1 retinol-binding protein 4 precursor [Xenopus laevis] ------------------------------------------------------------ ----------------------ME--RKVLG----------------------------- ----------------------------------------------LLIAL--------- ------GFLG-SCL-------------AEKNCRVDNFEVMKDFNKERYAGVWYAVAKKDP EGLFLLDNIVANFKIEDNGKMTA-----TAKGRVRILDKLELCANMVGTFI--ETNDPAK YRMKYHGALAILERGLDDHWVVDTDYTTYAITYACRRRNLDGTCR--DSYSFVFSRDING LPSESQRIVRRRQEQLCLDRKYRVVVHNGYCETN-------------------------- -------------- >XP_030854074.1 uncharacterized protein LOC115929361 isoform X2 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ----------------------MEFVAEAHVPEGSTTPSKLLLQPRGVPVPAEDYWVIYT DYVDHALVYSCSQRNEDGTCPEDRARVWFLGRAGTLSVDARHHMESLLSGLCVEVSRMQD ISTGCDAELG-VPTS-VEAMPHAHGGMVSSTCLVNDIHTMANFDKNQYTGTWYVISHL-- QGDIYPYHRISHYTLDEQNSFRMLTHRITSPGECSTAWKFEGQAYNPDT-----SETTSK LVLKPFGMPVY----GEDYWVIYTDYTDHALIYSCRETNEDGTCKAEASHAWMMSRDPT- LTPAARSHMEMLLTEMCVDVS-RLVDTPHECDELLGPESLIDQGRIIAPLHVF-LWRNVL KVLSL---------
BMGE Cleaned alignment of selected proteins >sp|P02753|RET4_HUMAN Retinol-binding protein 4 OS=Homo sapiens OX=9606 GN=RBP4 PE=1 SV=3 MKWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >tr|Q6PC07|Q6PC07_DANRE Purpurin OS=Danio rerio OX=7955 GN=rbp4l PE=1 SV=1 MGFYKFFSASCAVESFTVKDDFDPKRYAGKWYAQQKKDPEGLFLQDNISAEYTIDDDGTMTASSKGRVTLFGFWVVCADMAAQYSDPTTPAKMFMNYQGLASYLSSGGDNYWVIDTDYDNYAITYACRTLKDDGSCDDGYSLVFSRNPRGLPPAIQRLVRQKQDEICMAGQFQPVLQSGAC--------- >NP_035385.1 retinol-binding protein 4 isoform 2 precursor [Mus musculus] MEWVWAAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPNGLSPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL >NP_037294.1 retinol-binding protein 4 precursor [Rattus norvegicus] MEWVWAAERDCRVSSFRVKENFDKARFSGLWYAIAKKDPEGLFLQDNIIAEFSVDEKGHMSATAKGRVRLLSNWEVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFALQYSCRLQNLDGTCADSYSFVFSRDPNGLTPETRRLVRQRQEELCLERQYRWIEHNGYCQSRPSRNSL >NP_001035565.2 retinol-binding protein 4 precursor [Bos taurus] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETFAVQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL >XP_025007256.1 retinol-binding protein 4 isoform X1 [Gallus gallus] MAYTWRAERDCRVSSFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDENGQMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS-------- >NP_999222.1 retinol-binding protein 4 precursor [Sus scrofa] MEWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAAQYSCRLQNLDGTCADSYSFVFARDPHGFSPEVQKIVRQRQEELCLARQYRLITHNGYCDGKSERNIL >NP_001038960.1 retinol-binding protein 4 precursor [Pan troglodytes] MKWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_534969.3 retinol-binding protein 4 [Canis lupus familiaris] MEWVWAAESDCRVSNFQVKKNFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGRMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPLEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSEPNTL >NP_001075790.1 retinol-binding protein 4 precursor [Oryctolagus cuniculus] MEWVWAGERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQRGNDDHWIIDTDYDTFAVQYSCRLLNFDGTCADSYSFVFSRDPHGLPPDVQKLVRQRQEELCLSRQYRLIVHNGYCDDKSVRNLL >XP_002821040.1 retinol-binding protein 4 isoform X1 [Pongo abelii] MKWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_003208093.1 retinol-binding protein 4 [Meleagris gallopavo] MAYTRRAERDCRVSNFKVKENFDKNRYSGTWYAMAKKDPEGLFLQDNVVAQFTVDENGQMSATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRELNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQIDLCLDRKYRVIVHNGFCS-------- >XP_008948942.1 retinol-binding protein 4 [Pan paniscus] MKWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >NP_001277178.1 retinol binding protein 4 precursor [Felis catus] MAWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDENGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDSAKFKMKYWGVASFLQKGNDDHWIIDTDYDTYAVQYSCRLLNLDGTCADSYSFVFARDPNGLPPDVQKIVRQRQDELCLARQYRLIVHNGYCDGKSEQNIL >XP_027815955.1 retinol-binding protein 4 [Ovis aries] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNIL >XP_018890983.2 retinol-binding protein 4 [Gorilla gorilla gorilla] MKWVWAAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL >XP_004080296.1 retinol-binding protein 4 [Oryzias latipes] ------LENNCQIANFQVKQDFDRTRYAGVWYAVGKKDPEGLFLLDNVVAEFKVEDDGRMTATAKGRVIILNNWEMCAHMFATFEDTPEPAKFRMKYWGAASYLQTGNDEHWVIDTDYDNYAIHYSCRLLDSDGTCLDSYSFVFSRHPTGLRAEDQAIITQKKNDICLLGKYRRVAHNGFCDNTADLSQQ >XP_005507020.2 retinol-binding protein 4 isoform X1 [Columba livia] MAHTERAERDCRVSSFKVKENFDKSRYSGIWYAMAKKDPEGLFLQDNVVAEFTVDENGQMTATAKGRVRLFNNWDVCADMIGSFTDTEDPAKFKMKYWGVASFLQKGNDDHWVVDTDYDTYALHYSCRQLNEDGTCADSYSFVFSRDPKGLPPEAQKIVRQRQVDLCLERKYRVIVHNGFCS-------- >XP_017896583.1 PREDICTED: retinol-binding protein 4 isoform X1 [Capra hircus] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYAVQYSCRLLNLDGTCADSYSFVFARDPSGFAPEVQKIVRQRQEELCLARQYRLIPHKVTV--MASQKET >XP_006259744.1 PREDICTED: retinol-binding protein 4 [Alligator mississippiensis] MAGARTAERDCRVSGFRVQDNFDKARYSGIWYAMAKKDPEGLFLQDNVVAEFSVDEYGQMSATAKGRVRLFNNWDICADMIGSFTDTEDPAKFKMKYWGVAAYLQRGNDDHWIVDTDYDTYAIHYSCRELNDDGTCADSYSFVFSRDINGLSPEAQRIVRQRQVELCLDRKYRLIVHNGYCS-------- >XP_015818632.1 PREDICTED: retinol-binding protein 4 [Nothobranchius furzeri] ------WANDCQVANFQVKQDFDKTRYAGTWYAVGKKDPEGLFLLDNVVAEFTVDEEGKMTATAKGRVIILNNWEMCAHMFATFEETPEPAKLKMKYWGAASYLQTGNDEHWVIDTDYDNYAIHYSCRALDTTGTCLDSYSFVFSRHSAGLRPEDQAIITQRKTELCLLGKYRRVEHNGFCDVPQ----- >XP_020764164.1 retinol-binding protein 4 [Odocoileus virginianus texanus] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQRIVRQRQEELCLARQYRLIPHNGYCDGRSERNTL >XP_030256003.1 retinol-binding protein 4 isoform X1 [Sparus aurata] MT--SRWAQDCQVANIQVMQNFDKTRYAGTWYAVGKKDPEGLFLIDNIVAQFTIHEDGAMTATAKGRVIILNNWEMCADMMATFETTPDPAKFRMRYWGAASYLQTGNDDHWVIATDYDNYAIHYSCRVVDSDGTCLDSYSFVFSRHATGLRQEDVEIIVQKKTELCLLHKYRRVAHTGFCDSS------ >XP_040217704.1 retinol-binding protein 4 [Rana temporaria] MD--LKAERDCRVSTFKTMETFDRQRYAGTWYAVAKKDPEGLFLYDDIVAHFSIDEEGKMTATARGRVFLMGTIEVCADMVGLFQDTDDPAKFVMKYYGLASYLEKGVDNHWVVDTDYDNYAIVYSCREMGDNGDCLDDYSFIFSRNQNGLTPEAQRNVRRKQSELCLDRKYRIVPQNGVCNQIY----- >XP_043332130.1 retinol-binding protein 4 [Cervus canadensis] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGYCDGKSERNTL >KAB0346979.1 hypothetical protein FD754_011836 [Muntiacus muntjak] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQRIVRQRQEELCLARQYRLIPHNGKF--KTERTLL >KAB0384699.1 hypothetical protein FD755_006616 [Muntiacus reevesi] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQRIVRQRQEELCLARQYRLIPHNGHS--EQSIKLL >KAF4019100.1 hypothetical protein G4228_010897 [Cervus hanglu yarkandensis] MEWVWAAERDCRVSSFRVKENFDKARFAGTWYAMAKKDPEGLFLQDNIVAEFSVDENGHMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIIDTDYETYALQYSCRLLNLDGTCADSYSFVFARDPSGFSPEVQKIVRQRQEELCLARQYRLIPHNGEW--RVGAGSL >NP_001081195.1 retinol-binding protein 4 precursor [Xenopus laevis] ME--RKAEKNCRVDNFEVMKDFNKERYAGVWYAVAKKDPEGLFLLDNIVANFKIEDNGKMTATAKGRVRILDKLELCANMVGTFIETNDPAKYRMKYHGALAILERGLDDHWVVDTDYTTYAITYACRRRNLDGTCRDSYSFVFSRDINGLPSESQRIVRRRQEQLCLDRKYRVVVHNGYCETN------ >XP_030854074.1 uncharacterized protein LOC115929361 isoform X2 [Strongylocentrotus purpuratus] MEFVAEVSSTCLVNDIHTMANFDKNQYTGTWYVISHL--QGDIYPYHRISHYTLDEQNSFRMTSPGECSTAWKFEGQAYNPDT---SETTSKLVLKPFGMPVY----GEDYWVIYTDYTDHALIYSCRETNEDGTCKASHAWMMSRDPT-LTPAARSHMEMLLTEMCVDVS-RLVDTPHECDELLGPESL
PhyML tree of selected proteins (XP_030854074_1_uncharacterized_protein_LOC115929361_isoform_X2__Strongylocentrotus_purpuratus_:3.09919782,XP_040217704_1_retinol_binding_protein_4__Rana_temporaria_:0.42073264,(NP_001081195_1_retinol_binding_protein_4_precursor__Xenopus_laevis_:0.49243611,((((XP_008948942_1_retinol_binding_protein_4__Pan_paniscus_:0.00000001,(XP_002821040_1_retinol_binding_protein_4_isoform_X1__Pongo_abelii_:0.00000001,(NP_001038960_1_retinol_binding_protein_4_precursor__Pan_troglodytes_:0.00000001,(sp_P02753_RET4_HUMAN_Retinol_binding_protein_4_OS_Homo_sapiens_OX_9606_GN_RBP4_PE_1_SV_3:0.00000001,XP_018890983_2_retinol_binding_protein_4__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.01401975,(XP_534969_3_retinol_binding_protein_4__Canis_lupus_familiaris_:0.06250426,((NP_001277178_1_retinol_binding_protein_4_precursor__Felis_catus_:0.03719899,(NP_999222_1_retinol_binding_protein_4_precursor__Sus_scrofa_:0.02033514,(NP_001035565_2_retinol_binding_protein_4_precursor__Bos_taurus_:0.00632152,(XP_027815955_1_retinol_binding_protein_4__Ovis_aries_:0.00000001,(XP_017896583_1_PREDICTED__retinol_binding_protein_4_isoform_X1__Capra_hircus_:0.08787324,(XP_043332130_1_retinol_binding_protein_4__Cervus_canadensis_:0.00000001,((KAB0346979_1_hypothetical_protein_FD754_011836__Muntiacus_muntjak_:0.02156191,KAB0384699_1_hypothetical_protein_FD755_006616__Muntiacus_reevesi_:0.04225226):0.01934383,(KAF4019100_1_hypothetical_protein_G4228_010897__Cervus_hanglu_yarkandensis_:0.06056689,XP_020764164_1_retinol_binding_protein_4__Odocoileus_virginianus_texanus_:0.00000001):0.0063408):0.00644957):0.00725664):0.00571073):0.00000001):0.02443286):0.02171341):0.01260687,(NP_001075790_1_retinol_binding_protein_4_precursor__Oryctolagus_cuniculus_:0.0530148,(NP_035385_1_retinol_binding_protein_4_isoform_2_precursor__Mus_musculus_:0.00000001,NP_037294_1_retinol_binding_protein_4_precursor__Rattus_norvegicus_:0.00637026):0.16295039):0.02958786):0.0143078):0.00969056):0.1123646,(XP_006259744_1_PREDICTED__retinol_binding_protein_4__Alligator_mississippiensis_:0.13975645,(XP_005507020_2_retinol_binding_protein_4_isoform_X1__Columba_livia_:0.04376479,(XP_003208093_1_retinol_binding_protein_4__Meleagris_gallopavo_:0.00744809,XP_025007256_1_retinol_binding_protein_4_isoform_X1__Gallus_gallus_:0.00668257):0.02294938):0.07417147):0.06016776):0.12835368,(tr_Q6PC07_Q6PC07_DANRE_Purpurin_OS_Danio_rerio_OX_7955_GN_rbp4l_PE_1_SV_1:1.1230968,(XP_030256003_1_retinol_binding_protein_4_isoform_X1__Sparus_aurata_:0.19175684,(XP_015818632_1_PREDICTED__retinol_binding_protein_4__Nothobranchius_furzeri_:0.10472468,XP_004080296_1_retinol_binding_protein_4__Oryzias_latipes_:0.14374577):0.05168076):0.38579782):0.14291196):0.12281063):0.10013701);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)