PB0207

DATABASE

Click here to access PB0207 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0207	Q15165	Serum paraoxonase/arylesterase 2	PON2	paraoxonase 2	Homo_sapiens	Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.

Domains

Gene Ontology

PF01731 (Arylesterase)

GO:0004064 (enables) arylesterase activity GO:0016787 (enables) hydrolase activity GO:0042802 (enables) identical protein binding GO:0046872 (enables) metal ion binding GO:0102007 (enables) acyl-L-homoserine-lactone lactonohydrolase activity GO:0006979 (involved in) response to oxidative stress GO:0009636 (involved in) response to toxic substance GO:0019439 (involved in) aromatic compound catabolic process GO:0005576 (located in) extracellular region GO:0005634 (located in) nucleus GO:0005739 (located in) mitochondrion GO:0005764 (located in) lysosome GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0043231 (located in) intracellular membrane-bounded organelle

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q15165|PON2_HUMAN Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 PE=1 SV=4 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-1|PON2_HUMAN Isoform 1 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-3|PON2_HUMAN Isoform 3 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKY LETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTN MNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSE KPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >tr|Q6NXA5|Q6NXA5_DANRE Paraoxonase OS=Danio rerio OX=7955 GN=pon2 PE=1 SV=1 MGTLAFLSLAVVAFAVLIGERLISLRHVALSYRELTQNYLPNCNFIEGIDFGAEDITILD GLAFLSTGLKYPGVPSYSEDPGKIYTLNLLDSEQKIKVLHIRGDFDKDSFNPHGISVYTD DKDGAIYLFVVNHPQGKSQVEIFRFLENENALEYLKTIRHELLHNVNDIVAVGTESFYAT NDHYFTNDILKIVEPFLSLPWCDVVYYSPETVQVVAGGFLSANGINISPDKRHLYVSHIL KHTIAVLEIQKNTVLSHVKEIDVGSLCDNIEVDRETGDLWIGCHPNGLKCVFHDPNDPPG SEVIRIENILSEKPQVTQVYSDDGSVIIASSVAAPYREKLLIGTVYQKALICDLK
Selected proteins from model organisms >sp|Q15165|PON2_HUMAN Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 PE=1 SV=4 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-1|PON2_HUMAN Isoform 1 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 MGAWVGCGLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADIL AHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPS SEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-3|PON2_HUMAN Isoform 3 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 MGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFI DNEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKY LETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTN MNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSE KPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >tr|Q6NXA5|Q6NXA5_DANRE Paraoxonase OS=Danio rerio OX=7955 GN=pon2 PE=1 SV=1 MGTLAFLSLAVVAFAVLIGERLISLRHVALSYRELTQNYLPNCNFIEGIDFGAEDITILD GLAFLSTGLKYPGVPSYSEDPGKIYTLNLLDSEQKIKVLHIRGDFDKDSFNPHGISVYTD DKDGAIYLFVVNHPQGKSQVEIFRFLENENALEYLKTIRHELLHNVNDIVAVGTESFYAT NDHYFTNDILKIVEPFLSLPWCDVVYYSPETVQVVAGGFLSANGINISPDKRHLYVSHIL KHTIAVLEIQKNTVLSHVKEIDVGSLCDNIEVDRETGDLWIGCHPNGLKCVFHDPNDPPG SEVIRIENILSEKPQVTQVYSDDGSVIIASSVAAPYREKLLIGTVYQKALICDLK >NP_001013606.1 serum paraoxonase/arylesterase 2 precursor [Bos taurus] MGRLLALSLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVGLK CPGLHSFAPDKPGGILMMDLNEENPRALELRVSRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPN EVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVL VGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRAL YCEL >NP_899131.1 serum paraoxonase/arylesterase 2 [Mus musculus] MGRMVALSLLGIGLALLGERFLALRSRLKASREVESVDLPNCHLIKGIETGAEDIDILPNGLAFFSVGLK FPGLHSFAPDKPGGILMMDLKDERPRALELRVSWGFDLASFNPHGISTFIDDDDTVYLFVVNHPQFKSTV EIFKFQEEENSLLHLKTIKHELLPSVNDIIAVGPTHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPE EVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVLQLGTLVDNLSIDPSSGDIW VGCHPNGQRLFVYHPNHPPASEVLRIQNILSEKPSVTTVYINNGSVLQGSSVATIYDRKLLVGTLYQKAL YCEL >NP_001003205.2 serum paraoxonase/arylesterase 2 precursor [Canis lupus familiaris] MGRLLAVGLLGLALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGADDIDILPNGLAFFSVGLK CPGLHSFSPDKPGGILLMDLKKENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPD EVKVVAEGFDAANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDIL VGCHPNGQKLFIYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDRKLLIGTLYHRAL YCEL >XP_519213.3 serum paraoxonase/arylesterase 2 isoform X1 [Pan troglodytes] MAPPTELLARPERSSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIE AGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPF LKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLK VLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQG SSVASVYDGKLLIGTLYHRALYCEL >NP_001116695.1 serum paraoxonase/arylesterase 2 precursor [Sus scrofa] MGRLLALSLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGSEDIDILPSGLAFFSVGLK CPGLHSFAPDKPGGILMMDLKEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPN EVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKQPNMNLTXLKVLELDTLVDNISIDPSSGDIL VGCHPNGQKLFVYDANNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRAL YCEL >NP_001119820.1 serum paraoxonase/arylesterase 2 precursor [Ovis aries] MGRLLALSLLGIALALLGERLLTLRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVGLK CPGLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHYFSDPFLKYLETYLNLRWTNVVYYSPN EVKVVVEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVL VGCHPNGQKLFVYDPKNPPSSEVLRIQDILSEKPTVTTVYANNGSVLQGSSAASVYDKKLLIGTLYHRAL YCEL >XP_002713838.1 PREDICTED: serum paraoxonase/arylesterase 2 [Oryctolagus cuniculus] MGRLVAVSVLGIALALLGERLLALRNRLKASREIESVDLPNCHLIKGIEAGSEDIDILPNGLAFFSVGLK CPGLHSFAPDKPGGILMMDLKEERPRALELRISRGFDLASFNPHGISTFIDDDDTIYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIRHELLPSVNDVIAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVIYYSPN EVKVVADGFDSANGINISPDKKYIYVADILAHEIHVLDKHSNMNLTQLKVLQLDTLVDNLSVDPSSGDIW AGCHPNGQKVYVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRAL YCEL >XP_002818289.1 serum paraoxonase/arylesterase 2 [Pongo abelii] MAPPTELLARPERGSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIE AGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPF LKYLETYLNLHWANVVYYSPNEVKVVAEGYDSANGINISPDNKYIYVADILAHEIHVLEKHPNMNLTQLK VLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQG SSVASVYDGKLLIGTLYHRALYCEL >XP_003809757.2 serum paraoxonase/arylesterase 2 isoform X1 [Pan paniscus] MAPPTELLARPERSSAPGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIE AGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPF LKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLK VLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQG SSVASVYDGKLLIGTLYHRALYCEL >XP_023106134.1 serum paraoxonase/arylesterase 2 [Felis catus] MGRLVALSLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGADDIDILPNGLAFFSVGLK CPGLHSFSPDKPGGILMMDLKEENPRALELRISRGFNLASFNPHGISTFIDRDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKYLETYLNLHWANVVYYSPD EVKVVAEGFDAANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDIF VGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDRKLLIGTLYHRAL YCEL >XP_018886552.1 serum paraoxonase/arylesterase 2 isoform X1 [Gorilla gorilla gorilla] MAPPTELLARPERGSARGSRAMGRLVAVGLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIE AGSEDIDILPNGLAFFSVGLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTF IDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPF LKYLETYLNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLK VLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQG SSVASVYDGKLLIGTLYHRALYCEL >XP_017902886.1 PREDICTED: serum paraoxonase/arylesterase 2 [Capra hircus] MGRLLALSLLGIALALLGERLLTLRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVGLK CPGLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHYFSDPFLKYLETYLNLRWTNVVYYSPN EVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVL VGCHPNGQKLFVYDPKNPPSSEVLRIQDILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRAL YCEL >XP_020738325.1 serum paraoxonase/arylesterase 2 [Odocoileus virginianus texanus] MGRLLALSLLGIALALLGERFLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVGLK CPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTV EIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPN EVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVL VGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRAL YCEL >XP_043318581.1 serum paraoxonase/arylesterase 2 [Cervus canadensis] MGRLLALSLLGIALALLGERFLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVGLKCPSLHSFAPD KPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKH ELLPSVNDIIAVGPEHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKFIYVADIL AHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVY ANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >NP_001013100.1 serum paraoxonase/arylesterase 2 [Rattus norvegicus] MGRLVALSLLGIGLALLGERFLALRSRLKASREVESVDLPNCRLIKGIETGAEDIDILPNGLAFFSVGLKFPGLHSFAPD KPGGILMMDLKEEKPRALELRVSWGFDLASFNPHGISTFIDDDDTVYLFVVNHPEFKNTVEIFKFQEEENSLLHLKTIKH ELLPSVNDVIAVGPSHFYATNDHYFSDPFLKYLETYLNLRWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADIL AHEIHVLEKQPNMNLTQLKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNHPPSSEVLRIQNILSEKPSVTTVY INNGSVLQGSSVATIYDRKLLVGTLYQRALYCEL >KAB0375885.1 hypothetical protein FD755_012528 [Muntiacus reevesi] MESYWGFPGSPTGKESACSAGDLGSIPGLERPSGERLGYSLQKTKSATVSTVSLSICHEVMGPDAMILGGVICISEVIDI SPGNLDSSLCFFQPSGLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVN HPEFKNTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPNEV KVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFV YDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >KAB0344076.1 hypothetical protein FD754_021002 [Muntiacus muntjak] MTIGKTIALTRRTFVGKVMSLLFNMLLVILEPRKTKSATVSTVSLSICQEVMGPDAMILGGVICISEVIDISPGNLDSSL CFFQPSISHEGLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFK NTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKYLETYLNLHWTNVVYYSPNEVKVVAE GFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKN PPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >NP_001188397.2 serum paraoxonase/arylesterase 2 precursor [Gallus gallus] MGKVLAAALVGIAAALAAERLLAFRNRLNATREVDPVALPNCHLIKGIETGSEDIDILPNGLAFISSGLKYPGLKSFAPD KPGEIFLMDLNEKKPKASELRISRGFDLGSFNPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFMEDDNSLVHLKTIRH DLLTSVNDVVAVGPDSFYATNDHYFSDFILMFLEMYLGLTWSNVVYYSPKEVKEVAAGFYSANGINISPDKKYIYIADIL DHNVHVMEKHADWNLTHVKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYDDPDNPPASEVLRIQNILAEQPTVTRVY AENGSVLQGTSVATVYDGKLLIGTVFHRALYCEL >XP_006258517.1 PREDICTED: serum paraoxonase/arylesterase 2 isoform X4 [Alligator mississippiensis] MGKLLALALAGIAAAFLAGRFVAFRNKLNASREMEPVELPNCHLIKGIEAGAEDIDILPNGLVFISSGLKYPGLKSFAPD KPGEILLMDLNEKNPKARELRISRGFDLASFNPHGISTYIDKDDSVYLFVVNHPHQKSTVEVFTFVEDDNSLKHLKTIKH DLLPSVNDILAVGPDGFYATNDHYFFDSVLMFLEMFLGLTWSNVVYYSPTEVKEVAGGFYSANGINMSPDEKYIYIADLL GHNIHVMEKHANWNLTQVKMLQLDTLIDNLFLDHSTGDIWAGCHPNGMKVFFYDPENPPGSEVLRIQNILSEKPLVSRVY AENGSVLQGSSVAAVHDGKLLIGTVFHKALYCEL >NP_001290116.1 serum paraoxonase/arylesterase 2 precursor [Meleagris gallopavo] MGKVLAAALIGIAAALAAERLLAFRNRLNATREVDPVALPNCRLIKGIEAGSEDIDILPNGLAFISSGLKYPGLKSLAPD KPGEIFLMDLNEKKPKASELRISRGFDLGSFNPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFMEEDNSLLHLKTIRH DLLTSVNDVVAVGPDSFYATNDHYFYDFILMFLEMYLGLTWSNVVYYSPKEVKEVAAGFYSANGINISPDKKYIYIADIF DHNVHVMEKHADWNLTHVKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYNDPDNPPASEVLRIQNILAEQPTVTRVY AENGSVLQGTSVATVYNRKLLIGTVYHRALYCEL >XP_025064812.1 serum paraoxonase/arylesterase 2 isoform X2 [Alligator sinensis] MEPVELPNCHLIKGIEAGAEDIDILPNGLVFISSGLKYPGVKSFAPDKPGEILLMDLNEKNPKARELRISRGFDLASFNP HGISTYIDKDDSVYLYVVNHPHQKSTVEVFTFVEDDNSLKHLKTIKHDLLPSVNDLLAVGPDGFYATNDHYFFDSVLMFL EMFLGLTWSNVVYYSPTEVKEVAGGFYSANGINMSPDEKYIYIADLLGHNIHVMEKHANWNLTQVKVLQLDTLIDNLFLD HSTGDIWAGCHPNGMKVFLYDPENPPGSEVLRIQNILSEKPLVSRVYAENGSVLQGSSVAAVHDGKLLIGTVFHKALYCE L >XP_005504977.1 serum paraoxonase/arylesterase 2 [Columba livia] MRFSLKEHRLLRLNRLNASREIAPVTLPNCRLIKGIEAGSEDIDILPNGLAFISSGLKYPVLKNPELDKPGEIFLMDLNE DNPKAVELRISRGFDLASFVPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFVEDDNALVHVKTIRHDLLTSVNDVVAV GPDSFYATNDHYFFDHILMFLEMLLGLTWSNVVYYSPKEVKEVASGFYSANGINISPDRKYIYVADIFDHNIHVMEKHAN WSLTHVKTVQLDTMVDNLSIDPHTGDVWLGCHPDGMKLVYNDPENPPGSEVLRIQNILSEEPVVTCVYSDNGSVLQGTSV ASVYEGKLLIGTVFHRALYCEL >XP_043728287.1 serum paraoxonase/arylesterase 1 [Cervus elaphus] MAKLLVLTLLGLGLAFFKDHRSSYLARMNASREVKSVELPNCKLIKGIETGAEDLEILHNGLAFISAGLRYPGIKSFEPD KPGKILLMDLNEEDPTVLELKMTGSNFDASSFNPHGISTFTDEDNTVYLLVVSHPDFKSTVELFKFQEEEKSLLHLKTIK HELLPNLNDLVAVGPEHFYATNDHYFVDHYMRSWELYLGLAWSNVVYYSPDDIRVVASGFDFANGISMSPDSKYVYIAEL LAHKIHVYEKHANWTLTPLKSLDCNTLVDNLSVDPVTGDLWVGCHPNGMKIFSYDPENPPGSEVLQIQNILTEEPKVTVV YAEDGKVLHGSTVASVYKGKMLVGTVFHKALYCEL >XP_018122811.1 serum paraoxonase/arylesterase 2-like [Xenopus laevis] MGKLLKVTLIGILLAFIGERIVQFCHRVNMNREVDPVDLPNCQLVKGIEFGSEDIEILPNGLAFISSGLKFPGVMSLQPD KPSIIFLLDLNDEKLRPVSLRLSRGFDVSTFNPHGMSTYIDPKDDTVYLFVVNHPQYKTTIELFKFEEEENALLHLKTIE HDLLWSINDIVAVGPESFYATNDLYFTDFTMKQLEILLGIAWSNVVYYSPTEVKQVSSGYYYANGIAMSTDNKYIYVADI MGHTIDILEKQADWSLTPVKVLQLDSLVDNLFVDPNTGDLWTGAHPNGWKLFSYNSDDLPGSEVIRVQNIHSDNPIVTQV YVNNGSVIQASSSAAVYEGKLLIGTVFHKALCCELS >XP_040208238.1 serum paraoxonase/arylesterase 2-like [Rana temporaria] MGKLLKITLFGVFLAFLGERIVHFTDRINLVRDIEPVELPNCQLLAGIEYGSEDIEILPNGLAFISSGLKYPGMFSFAPS RPGEIFLLDLNDEELRPSSLRISRGFDISSFSPHGISIYIDETDDTVYLFVVNHPHISKSTVEIFKFAEDENVLVHLKTI KHASLYNVNDLVAVGPESFYATNDHYFTDFILRFVEMFLGLRWTNVVYYSPSDIREVATGFYSANGIAMSNDERFIYVAD VSGKAINVLEKHANFSLSPVKVLQLGALVDNLSVDPVTGDIWIGAHPNGFKLFKYSEEDPPGSEVIRVQNIHSDNPVVTT VYANDGSVLQASTCAAVWENNLLVGTIFHKALHCKLE >KAF7225980.1 serum paraoxonase/arylesterase 2-like [Nothobranchius furzeri] MGXLVFISIXVAVVAVLIGXRIINISKRYLAFREVTLNHLPNCVALKNLDHGTEDITILGHGLAFISTGLKYPGVPSGDV PGKIYTVDLNDPLLRPVELRMPRNFDLESFNPHGISIYIDPSDDAVFLFVVNHPQHKSQVELFKYVEENRSLIHLKTIKH ELLHSVNDIVAVGPESFYATNDHYFTNEILKSLEIYLLPPWTNVVYYSPKEVKVVSDGYTFANGINVSPDQKYIYVAAIF DHHVHVLERKEDNSLVPVKSVAVGSLCDNIEVEPETGDLWMGCHPNARKIFLFDPKDPPGSEVIRIQNIHSDHPVVTQVY ADDGQVIMGSSVAAPYGGKLLIGSVFHKGLCCDLK >XP_030250112.1 serum paraoxonase/arylesterase 2-like isoform X2 [Sparus aurata] MGKLVCLSIVVAALAALFGERVVNLRKRTLATRELVQNHLPNCVELKNLDYGSEDITILGNGLAFISTGLKYPGLPSQDV TAKLFVVDMKDSRKKPVELRMPRNFDLESFNPHGISLFTDPSDDAVYLFVVNHPQHKSQVELFKFAEEDFSLLHLKTITH ELLHSVNDIVAVGVDAFYATNDHYFSHHLLKAFVETFLVQPWCNVVYYSPEGVKVVSEGYYFPNGINLSPDKKHVYVVDL FDHNVHVLERKDDNGLVSVKSMHVGSLCDNVEVDPETGDLWLGCHPNAWKAFMLDPNDPPGSEVIRIQNIHSDKPAVTQV YADDGQVIVGSSVATTYEGKLLIGTVYHKALCCDLK >XP_004077858.1 serum paraoxonase/arylesterase 2 [Oryzias latipes] MAAVRKALIAAAVAAFAALFGRTFLKLKDISLASREIPVKRLNCQYLKNIDYGAEDITILKDGLAFLSTGLKYPGLHSFS DEPGKMYVLDLLHPKMTPVELQIKGQLDLSSFNPHGISVYEDEADDSIYVFVVNHPEHKSQVEIFRFVEEDTLMHLKTIT HPLLHSVNDIVAVGAEHFYATNDHYFHHEALQLLTFMFDLSWCDVVYYSPHEVRVVAGGFKSANGINISPDRQYIYVSDI MDHEIDIFRRNEGEQLAYVKSVAVGSLCDNIEVDRRTGDIWLGCHPNGLKLLKFDPEDPPGSEVIRIKNIHSERPVVSLE YGDDGRQLIASTVAVPYEGKLLIGSVFHKALLCIL >XP_038044970.1 serum paraoxonase/arylesterase 2-like isoform X2 [Patiria miniata] MFRNILIGISAALILQHILSVIYSLGFHKRAYNHRPGSCRVVTGIDSGSEDIHVLRNGLALITSGIDLTPLGHLMDPSGL TWKGRIYLFDFKQPNANVTELPILGSFDHSDFRPHGISVWEEETQTTVFVVNHKQHREAIEVLSLNQDNKSLQYLYSITD PLMRSVNDVVAVGSNSFYFTNDGYNNQLFKRFLERFLKFPWGNVIYYDGDAGRGQVVVSRGLEPNGINRSPDGRYIYVSS PIVGTVTVYEQQADHALQPIQVIDLSTSPDNIYVDSTSGDLWLGCHMIGYQSMLHFQNFTQPAASQVLHIQLNSKVAPYT YDIREAYVDDGRQVSGSSVAAYYNKQLLIGSVAHKLAHCQVVAF >CAE1156049.1 PON [Sepia pharaonis] MQHIFSLVSMFLFKGTIHNHSPGPCKYVPGVENGAEDLHTLPNGLTFISSGLTLDNPDVPSVSGRILLYDMSQSGENGAI ELEIENFDQREFVPHGISAWVDKTGEITIFVVNHHKQRERIESFQYQPEKKTLLHLKTYKDGSMRHMNDVLATSNKTFYF TNWSHSKSLWGLFLESFLLLPWTNVYYHDGEIYKLVAEDMVMANGLAMSADGKYVYVACTMTKDLKVFRRETDNSLTFHQ EHLVDTLVDNPTVDENGDVWIGCHPKILPAWVYMLNPIYGAPSQVIKLEIQDGLVKSMKEVYANDGTMLAASTVASFYKN QTLIGSLREKLLLCDVLYV >XP_031555871.1 serum paraoxonase/arylesterase 2-like [Actinia tenebrosa] MKLASFGRAVDLAVIVFVSSVIAHVFNTIVSFGYFKQVLGHSPGPCRAINVNGSEDVEILSNGMALFSSGLRYTVQLTTD PIINQRTGNIYLLDLNEHEPEPMIVTLKSFNRSDFNPHGISIYEDPTTGQVTFFVVNHKHNDQAVEIFSFDKKKKCMYHR RTVVDGKMYSPNDILAVGPESFYVTNDHYFHFSRPFLRMLEVAFLNIFLRSNVVYYDGSKSHLAVTGLVGPNGIIFDRSK RYVLVSAGFSNAIHVYKRQRDNSLLLSQKINIGTHADNINVDIDTGSFWIAGVPKGLDFAEYTRNLKHPAPSQVLNLRLN EERSGAIPFPDYELREVYLNDGREHRGSTSAAHFRGKLLIGGIYDKMLMCEVRAF >XP_001175598.3 serum paraoxonase/arylesterase 1-like [Strongylocentrotus purpuratus] MWKRLILVVLVAAVVRHVFTFLKVLGLEKTVYNHKPGNCQFVRGIEHGSEDLELLSDGIVIISEGYLTFKDRVEGAPRGH LFAYDINHHNNGATELKITGDYDVEKLHPHGITAFEDKKTKKTFLLVINHHVRFDVVDVFEFHRSSMSLSFIKSMRDPLM TSVNNLIATGPEEFYITNEAYFLHPRMRDLENFLVMRMGSVLYCDVTGCKKATESLNNPNGIDLSRDGRYLYVSQPFTRQ VRIYKRDPSDNTLTANEGVHVIDLGTVADNVYVDESGDVWLGCLPVAHKALTYIDTKKGLVPSQVLRVRVGPKDYELSEV YSEDGRNITVSTSAVHHKGILLIGSLHERMMRCQVNAI >NP_491306.1 PON (paraoxonase) and MEC-6 Like [Caenorhabditis elegans] MLVKVVLFGLLGVSIHFIFNTLLTLDINKRVYNHRPGECRKIEGPVHGSEDIEVIDKLQIAFISSGLVYLPNSASDVKWK GQIFLYDLTKRSYKAEPIPVLNLEDVDGFHPHGLSHWILNNRTVRLFVVVHSKTFKHSIVILDYNSAKRELNHVKTIRGE KFVRPNDIVATGENSFLVSNDGGAQTALGNVWEILSGFYKGGLVYYNGKKSQFLMENNIANGIILSRDQKTLFVSHINQE TIGVYTWNQKDGEIQKISEIETLTGCDNFYVDTQDHLWAGCHPVVKDAAGHLGNVSDSTLYGPSQVLRVSFSKDLKTAEI VEVLADDGRFVSASTIAIPFDDGKQMIVGTVARPAIHCDINVSLNLY
Mafft alignment of selected proteins >sp|Q15165|PON2_HUMAN Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 PE=1 SV=4 ---------------------MGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >sp|Q15165-1|PON2_HUMAN Isoform 1 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 ---------------------MGAW--VGC---GLAGDRAGF---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >sp|Q15165-3|PON2_HUMAN Isoform 3 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 ---------------------MGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-N--- ---------EF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >tr|Q6NXA5|Q6NXA5_DANRE Paraoxonase OS=Danio rerio OX=7955 GN=pon2 PE=1 SV=1 ---------------------MGTL--AFLS--LAVVAFAVL---IGERLIS-LRHVALS YRELTQNYL--------PNCNFIEGIDFGAEDITIL-----DGLAFLST-----G-LKYP GV----PSYSED-PGKIYTLNLLDSEQK-IKVLHIR-GDFDKDSFNPHGISVYTDDKDGA IYLFVVNHPQG-KSQVEIFRFLENENALEYLKTIRHELLHNVNDIVAVGTESFYATNDHY FT--NDILK-IVE-PFL-SLPWCDVVYYSPETVQ--VVAGGFLSANGINISPDKRHLYVS HILKHTIAVLEIQ-KNTVLSH---VKEIDVGSLCDNIEVDRETGDLWIGCHPNGLKCVFH --DPNDP---PGSEVIRIENILSEKP-------QVTQVYSDDGSVIIASSVAAPYRE--K LLIGTVYQKALICDLK------ >NP_001013606.1 serum paraoxonase/arylesterase 2 precursor [Bos taurus] ---------------------MGRL--LAL---SLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGAEDIDILP----NGLAFFSV-----G-LKCP GL----HSFAPDKPGGILMMDLNEENPR-ALELRVS-RGFNLASFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >NP_899131.1 serum paraoxonase/arylesterase 2 [Mus musculus] ---------------------MGRM--VAL---SLLGIGLAL---LGERFLA-LRSRLKA SREVESVDL--------PNCHLIKGIETGAEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKDERPR-ALELRVS-WGFDLASFNPHGISTFID-DDDT VYLFVVNHPQF-KSTVEIFKFQEEENSLLHLKTIKHELLPSVNDIIAVGPTHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPEEVK--LVAEGFDSANGINISPDKKYVYVA DILAHEIHVLEKQ-PNMNLTQ---LKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQRLFVY --HPNHP---PASEVLRIQNILSEKP-------SVTTVYINNGSVLQGSSVATIYDR--K LLVGTLYQKALYCEL------- >NP_001003205.2 serum paraoxonase/arylesterase 2 precursor [Canis lupus familiaris] ---------------------MGRL--LAV---GLLGLALAL---LGERLLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGADDIDILP----NGLAFFSV-----G-LKCP GL----HSFSPDKPGGILLMDLKKENPR-ALELRIS-RGFNLASFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPDEVK--VVAEGFDAANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDILVGCHPNGQKLFIY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDR--K LLIGTLYHRALYCEL------- >XP_519213.3 serum paraoxonase/arylesterase 2 isoform X1 [Pan troglodytes] MAPPTELLARPERSSAPGSRAMGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >NP_001116695.1 serum paraoxonase/arylesterase 2 precursor [Sus scrofa] ---------------------MGRL--LAL---SLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGSEDIDILP----SGLAFFSV-----G-LKCP GL----HSFAPDKPGGILMMDLKEENPR-ALELRIS-RGFNLASFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKQ-PNMNLTX---LKVLELDTLVDNISIDPSSGDILVGCHPNGQKLFVY --DANNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >NP_001119820.1 serum paraoxonase/arylesterase 2 precursor [Ovis aries] ---------------------MGRL--LAL---SLLGIALAL---LGERLLT-LRNRLKA SREVESVDL--------PNCHLIKGIEAGAEDIDILP----NGLAFFSV-----G-LKCP GL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLASFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLRWTNVVYYSPNEVK--VVVEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQDILSEKP-------TVTTVYANNGSVLQGSSAASVYDK--K LLIGTLYHRALYCEL------- >XP_002713838.1 PREDICTED: serum paraoxonase/arylesterase 2 [Oryctolagus cuniculus] ---------------------MGRL--VAV---SVLGIALAL---LGERLLA-LRNRLKA SREIESVDL--------PNCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKCP GL----HSFAPDKPGGILMMDLKEERPR-ALELRIS-RGFDLASFNPHGISTFID-DDDT IYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIRHELLPSVNDVIAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVIYYSPNEVK--VVADGFDSANGINISPDKKYIYVA DILAHEIHVLDKH-SNMNLTQ---LKVLQLDTLVDNLSVDPSSGDIWAGCHPNGQKVYVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >XP_002818289.1 serum paraoxonase/arylesterase 2 [Pongo abelii] MAPPTELLARPERGSAPGSRAMGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGYDSANGINISPDNKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >XP_003809757.2 serum paraoxonase/arylesterase 2 isoform X1 [Pan paniscus] MAPPTELLARPERSSAPGSRAMGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >XP_023106134.1 serum paraoxonase/arylesterase 2 [Felis catus] ---------------------MGRL--VAL---SLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGADDIDILP----NGLAFFSV-----G-LKCP GL----HSFSPDKPGGILMMDLKEENPR-ALELRIS-RGFNLASFNPHGISTFID-RDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPDEVK--VVAEGFDAANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDIFVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDR--K LLIGTLYHRALYCEL------- >XP_018886552.1 serum paraoxonase/arylesterase 2 isoform X1 [Gorilla gorilla gorilla] MAPPTELLARPERGSARGSRAMGRL--VAV---GLLGIALAL---LGERLLA-LRNRLKA SREVESVDL--------PHCHLIKGIEAGSEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ARELRIS-RGFDLASFNPHGISTFID-NDDT VYLFVVNHPEF-KNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHY FS--DPFLK-YLE-TYL-NLHWANVVYYSPNEVK--VVAEGFDSANGINISPDDKYIYVA DILAHEIHVLEKH-TNMNLTQ---LKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDG--K LLIGTLYHRALYCEL------- >XP_017902886.1 PREDICTED: serum paraoxonase/arylesterase 2 [Capra hircus] ---------------------MGRL--LAL---SLLGIALAL---LGERLLT-LRNRLKA SREVESVDL--------PNCHLIKGIEAGAEDIDILP----NGLAFFSV-----G-LKCP GL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLASFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLRWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQDILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >XP_020738325.1 serum paraoxonase/arylesterase 2 [Odocoileus virginianus texanus] ---------------------MGRL--LAL---SLLGIALAL---LGERFLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGAEDIDILP----NGLAFFSV-----G-LKCP SL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLALFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >XP_043318581.1 serum paraoxonase/arylesterase 2 [Cervus canadensis] ---------------------MGRL--LAL---SLLGIALAL---LGERFLA-LRNRLKA SREVESVDL--------PNCHLIKGIEAGAEDIDILP----NGLAFFSV-----G-LKCP SL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLALFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKFIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >NP_001013100.1 serum paraoxonase/arylesterase 2 [Rattus norvegicus] ---------------------MGRL--VAL---SLLGIGLAL---LGERFLA-LRSRLKA SREVESVDL--------PNCRLIKGIETGAEDIDILP----NGLAFFSV-----G-LKFP GL----HSFAPDKPGGILMMDLKEEKPR-ALELRVS-WGFDLASFNPHGISTFID-DDDT VYLFVVNHPEF-KNTVEIFKFQEEENSLLHLKTIKHELLPSVNDVIAVGPSHFYATNDHY FS--DPFLK-YLE-TYL-NLRWANVVYYSPEEVK--LVAEGFDSANGINISPDKKYVYVA DILAHEIHVLEKQ-PNMNLTQ---LKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQKLFVY --DPNHP---PSSEVLRIQNILSEKP-------SVTTVYINNGSVLQGSSVATIYDR--K LLVGTLYQRALYCEL------- >KAB0375885.1 hypothetical protein FD755_012528 [Muntiacus reevesi] MESYWGF-----PGSP-----TGKE--SACSA-GDLGSIPGLERPSGERLG--YSLQKTK SATVSTVSLSICHEVMGPDAMILGGVICISEVIDISPGNLDSSLCFFQPS----G-LKCP SL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLALFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >KAB0344076.1 hypothetical protein FD754_021002 [Muntiacus muntjak] MT-------------------IGKT--IALTRRTFVGKVMSL---LFNMLLVILEPRKTK SATVSTVSLSICQEVMGPDAMILGGVICISEVIDISPGNLDSSLCFFQPSISHEG-LKCP SL----HSFAPDKPGGILMMDLNEENPR-ALELRIS-RGFNLALFNPHGISTFID-SDDT VYLFVVNHPEF-KNTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHY FS--DPFLK-YLE-TYL-NLHWTNVVYYSPNEVK--VVAEGFDSANGINISPDKKYIYVA DILAHEIHVLEKH-PNMNLTQ---LKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVY --DPKNP---PSSEVLRIQNILSEKP-------TVTTVYANNGSVLQGSSVASVYDK--K LLIGTLYHRALYCEL------- >NP_001188397.2 serum paraoxonase/arylesterase 2 precursor [Gallus gallus] ---------------------MGKV--LAA---ALVGIAAAL---AAERLLA-FRNRLNA TREVDPVAL--------PNCHLIKGIETGSEDIDILP----NGLAFISS-----G-LKYP GL----KSFAPDKPGEIFLMDLNEKKPK-ASELRIS-RGFDLGSFNPHGISTYID-KDDT VYLFVVNHPHQ-KSTVELFKFMEDDNSLVHLKTIRHDLLTSVNDVVAVGPDSFYATNDHY FS--DFILM-FLE-MYL-GLTWSNVVYYSPKEVK--EVAAGFYSANGINISPDKKYIYIA DILDHNVHVMEKH-ADWNLTH---VKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYD --DPDNP---PASEVLRIQNILAEQP-------TVTRVYAENGSVLQGTSVATVYDG--K LLIGTVFHRALYCEL------- >XP_006258517.1 PREDICTED: serum paraoxonase/arylesterase 2 isoform X4 [Alligator mississippiensis] ---------------------MGKL--LAL---ALAGIAAAF---LAGRFVA-FRNKLNA SREMEPVEL--------PNCHLIKGIEAGAEDIDILP----NGLVFISS-----G-LKYP GL----KSFAPDKPGEILLMDLNEKNPK-ARELRIS-RGFDLASFNPHGISTYID-KDDS VYLFVVNHPHQ-KSTVEVFTFVEDDNSLKHLKTIKHDLLPSVNDILAVGPDGFYATNDHY FF--DSVLM-FLE-MFL-GLTWSNVVYYSPTEVK--EVAGGFYSANGINMSPDEKYIYIA DLLGHNIHVMEKH-ANWNLTQ---VKMLQLDTLIDNLFLDHSTGDIWAGCHPNGMKVFFY --DPENP---PGSEVLRIQNILSEKP-------LVSRVYAENGSVLQGSSVAAVHDG--K LLIGTVFHKALYCEL------- >NP_001290116.1 serum paraoxonase/arylesterase 2 precursor [Meleagris gallopavo] ---------------------MGKV--LAA---ALIGIAAAL---AAERLLA-FRNRLNA TREVDPVAL--------PNCRLIKGIEAGSEDIDILP----NGLAFISS-----G-LKYP GL----KSLAPDKPGEIFLMDLNEKKPK-ASELRIS-RGFDLGSFNPHGISTYID-KDDT VYLFVVNHPHQ-KSTVELFKFMEEDNSLLHLKTIRHDLLTSVNDVVAVGPDSFYATNDHY FY--DFILM-FLE-MYL-GLTWSNVVYYSPKEVK--EVAAGFYSANGINISPDKKYIYIA DIFDHNVHVMEKH-ADWNLTH---VKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYN --DPDNP---PASEVLRIQNILAEQP-------TVTRVYAENGSVLQGTSVATVYNR--K LLIGTVYHRALYCEL------- >XP_025064812.1 serum paraoxonase/arylesterase 2 isoform X2 [Alligator sinensis] ------------------------------------------------------------ ---MEPVEL--------PNCHLIKGIEAGAEDIDILP----NGLVFISS-----G-LKYP GV----KSFAPDKPGEILLMDLNEKNPK-ARELRIS-RGFDLASFNPHGISTYID-KDDS VYLYVVNHPHQ-KSTVEVFTFVEDDNSLKHLKTIKHDLLPSVNDLLAVGPDGFYATNDHY FF--DSVLM-FLE-MFL-GLTWSNVVYYSPTEVK--EVAGGFYSANGINMSPDEKYIYIA DLLGHNIHVMEKH-ANWNLTQ---VKVLQLDTLIDNLFLDHSTGDIWAGCHPNGMKVFLY --DPENP---PGSEVLRIQNILSEKP-------LVSRVYAENGSVLQGSSVAAVHDG--K LLIGTVFHKALYCEL------- >XP_005504977.1 serum paraoxonase/arylesterase 2 [Columba livia] -------------------------------------MRFSL---KEHRLLR-L-NRLNA SREIAPVTL--------PNCRLIKGIEAGSEDIDILP----NGLAFISS-----G-LKYP VL----KNPELDKPGEIFLMDLNEDNPK-AVELRIS-RGFDLASFVPHGISTYID-KDDT VYLFVVNHPHQ-KSTVELFKFVEDDNALVHVKTIRHDLLTSVNDVVAVGPDSFYATNDHY FF--DHILM-FLE-MLL-GLTWSNVVYYSPKEVK--EVASGFYSANGINISPDRKYIYVA DIFDHNIHVMEKH-ANWSLTH---VKTVQLDTMVDNLSIDPHTGDVWLGCHPDGMKLVYN --DPENP---PGSEVLRIQNILSEEP-------VVTCVYSDNGSVLQGTSVASVYEG--K LLIGTVFHRALYCEL------- >XP_043728287.1 serum paraoxonase/arylesterase 1 [Cervus elaphus] ---------------------MAKL--LVL---TLLGLGLAF---FKDHRSS-YLARMNA SREVKSVEL--------PNCKLIKGIETGAEDLEILH----NGLAFISA-----G-LRYP GI----KSFEPDKPGKILLMDLNEEDPT-VLELKMTGSNFDASSFNPHGISTFTD-EDNT VYLLVVSHPDF-KSTVELFKFQEEEKSLLHLKTIKHELLPNLNDLVAVGPEHFYATNDHY FV--DHYMR-SWE-LYL-GLAWSNVVYYSPDDIR--VVASGFDFANGISMSPDSKYVYIA ELLAHKIHVYEKH-ANWTLTP---LKSLDCNTLVDNLSVDPVTGDLWVGCHPNGMKIFSY --DPENP---PGSEVLQIQNILTEEP-------KVTVVYAEDGKVLHGSTVASVYKG--K MLVGTVFHKALYCEL------- >XP_018122811.1 serum paraoxonase/arylesterase 2-like [Xenopus laevis] ---------------------MGKL--LKV---TLIGILLAF---IGERIVQ-FCHRVNM NREVDPVDL--------PNCQLVKGIEFGSEDIEILP----NGLAFISS-----G-LKFP GV----MSLQPDKPSIIFLLDLNDEKLR-PVSLRLS-RGFDVSTFNPHGMSTYIDPKDDT VYLFVVNHPQY-KTTIELFKFEEEENALLHLKTIEHDLLWSINDIVAVGPESFYATNDLY FT--DFTMK-QLE-ILL-GIAWSNVVYYSPTEVK--QVSSGYYYANGIAMSTDNKYIYVA DIMGHTIDILEKQ-ADWSLTP---VKVLQLDSLVDNLFVDPNTGDLWTGAHPNGWKLFSY --NSDDL---PGSEVIRVQNIHSDNP-------IVTQVYVNNGSVIQASSSAAVYEG--K LLIGTVFHKALCCELS------ >XP_040208238.1 serum paraoxonase/arylesterase 2-like [Rana temporaria] ---------------------MGKL--LKI---TLFGVFLAF---LGERIVH-FTDRINL VRDIEPVEL--------PNCQLLAGIEYGSEDIEILP----NGLAFISS-----G-LKYP GM----FSFAPSRPGEIFLLDLNDEELR-PSSLRIS-RGFDISSFSPHGISIYIDETDDT VYLFVVNHPHISKSTVEIFKFAEDENVLVHLKTIKHASLYNVNDLVAVGPESFYATNDHY FT--DFILR-FVE-MFL-GLRWTNVVYYSPSDIR--EVATGFYSANGIAMSNDERFIYVA DVSGKAINVLEKH-ANFSLSP---VKVLQLGALVDNLSVDPVTGDIWIGAHPNGFKLFKY --SEEDP---PGSEVIRVQNIHSDNP-------VVTTVYANDGSVLQASTCAAVWEN--N LLVGTIFHKALHCKLE------ >KAF7225980.1 serum paraoxonase/arylesterase 2-like [Nothobranchius furzeri] ---------------------MGXL--VFIS--IXVAVVAVL---IGXRIIN-ISKRYLA FREVTLNHL--------PNCVALKNLDHGTEDITILG----HGLAFIST-----G-LKYP GV----PS--GDVPGKIYTVDLNDPLLR-PVELRMP-RNFDLESFNPHGISIYIDPSDDA VFLFVVNHPQH-KSQVELFKYVEENRSLIHLKTIKHELLHSVNDIVAVGPESFYATNDHY FT--NEILK-SLE-IYL-LPPWTNVVYYSPKEVK--VVSDGYTFANGINVSPDQKYIYVA AIFDHHVHVLERK-EDNSLVP---VKSVAVGSLCDNIEVEPETGDLWMGCHPNARKIFLF --DPKDP---PGSEVIRIQNIHSDHP-------VVTQVYADDGQVIMGSSVAAPYGG--K LLIGSVFHKGLCCDLK------ >XP_030250112.1 serum paraoxonase/arylesterase 2-like isoform X2 [Sparus aurata] ---------------------MGKL--VCLS--IVVAALAAL---FGERVVN-LRKRTLA TRELVQNHL--------PNCVELKNLDYGSEDITILG----NGLAFIST-----G-LKYP GL----PS--QDVTAKLFVVDMKDSRKK-PVELRMP-RNFDLESFNPHGISLFTDPSDDA VYLFVVNHPQH-KSQVELFKFAEEDFSLLHLKTITHELLHSVNDIVAVGVDAFYATNDHY FS--HHLLKAFVE-TFL-VQPWCNVVYYSPEGVK--VVSEGYYFPNGINLSPDKKHVYVV DLFDHNVHVLERK-DDNGLVS---VKSMHVGSLCDNVEVDPETGDLWLGCHPNAWKAFML --DPNDP---PGSEVIRIQNIHSDKP-------AVTQVYADDGQVIVGSSVATTYEG--K LLIGTVYHKALCCDLK------ >XP_004077858.1 serum paraoxonase/arylesterase 2 [Oryzias latipes] ---------------------MAAVRKALIA--AAVAAFAAL---FGRTFLK-LKDISLA SREIPVKRL---------NCQYLKNIDYGAEDITILK----DGLAFLST-----G-LKYP GL----HSFS-DEPGKMYVLDLLHPKMT-PVELQIK-GQLDLSSFNPHGISVYEDEADDS IYVFVVNHPEH-KSQVEIFRFVEED-TLMHLKTITHPLLHSVNDIVAVGAEHFYATNDHY FH--HEALQ-LLT-FMF-DLSWCDVVYYSPHEVR--VVAGGFKSANGINISPDRQYIYVS DIMDHEIDIFRRN-EGEQLAY---VKSVAVGSLCDNIEVDRRTGDIWLGCHPNGLKLLKF --DPEDP---PGSEVIRIKNIHSERP-------VVSLEYGDDGRQLIASTVAVPYEG--K LLIGSVFHKALLCIL------- >XP_038044970.1 serum paraoxonase/arylesterase 2-like isoform X2 [Patiria miniata] ---------------------MFRN--------ILIGISAAL---ILQHILS-VIYSLGF HKRAYNHRP--------GSCRVVTGIDSGSEDIHVLR----NGLALITS-----G-IDLT PLGHLMDPSGLTWKGRIYLFDFKQPNAN-VTELPIL-GSFDHSDFRPHGISVWEEET--Q TTVFVVNHKQH-REAIEVLSLNQDNKSLQYLYSITDPLMRSVNDVVAVGSNSFYFTNDGY NN--QLFKR-FLE-RFL-KFPWGNVIYYDGDAGRGQVVVSRGLEPNGINRSPDGRYIYVS SPIVGTVTVYEQQ-ADHALQP---IQVIDLSTSPDNIYVDSTSGDLWLGCHMIGYQSMLH FQNFTQP---AASQVLHIQLNSKVAPY----TYDIREAYVDDGRQVSGSSVAAYYNK--Q LLIGSVAHKLAHCQVVA----F >CAE1156049.1 PON [Sepia pharaonis] ----------------------------------------------MQHIFS-LVSMFLF KGTIHNHSP--------GPCKYVPGVENGAEDLHTLP----NGLTFISS-----G-LTLD ------NPDVPSVSGRILLYDMSQSGENGAIELEI--ENFDQREFVPHGISAWVD-KTGE ITIFVVNHHKQ-RERIESFQYQPEKKTLLHLKTYKDGSMRHMNDVLATSNKTFYFTNWSH SK--SLWGL-FLE-SFL-LLPWTNVYYHDGEIYK--LVAEDMVMANGLAMSADGKYVYVA CTMTKDLKVFRRE-TDNSLTF---HQEHLVDTLVDNPTVDE-NGDVWIGCHPKILPAWVY MLNPIYG---APSQVIKLEIQDGLVK-------SMKEVYANDGTMLAASTVASFYKN--Q TLIGSLREKLLLCDVLY----V >XP_031555871.1 serum paraoxonase/arylesterase 2-like [Actinia tenebrosa] MK----------LAS------FGRA--VD----LAVIVFVSS---VIAHVFN-TIVSFGY FKQVLGHSP--------GPCRAIN--VNGSEDVEILS----NGMALFSS-----G-LRYT VQ-LTTDPIINQRTGNIYLLDLNEHEPE-PMIVTL--KSFNRSDFNPHGISIYEDPTTGQ VTFFVVNHKHN-DQAVEIFSFDKKKKCMYHRRTVVDGKMYSPNDILAVGPESFYVTNDHY FHFSRPFLR-MLEVAFLNIFLRSNVVYYDGSKSH--LAVTGLVGPNGIIFDRSKRYVLVS AGFSNAIHVYKRQ-RDNSLLL---SQKINIGTHADNINVDIDTGSFWIAGVPKGLDFAEY TRNLKHP---APSQVLNLRLNEERSGAIPFPDYELREVYLNDGREHRGSTSAAHFRG--K LLIGGIYDKMLMCEVRA----F >XP_001175598.3 serum paraoxonase/arylesterase 1-like [Strongylocentrotus purpuratus] ---------------------MWKR--------LILVVLVAA---VVRHVFT-FLKVLGL EKTVYNHKP--------GNCQFVRGIEHGSEDLELLS----DGIVIISE-----GYLTFK ------DRVEGAPRGHLFAYDINHHNNG-ATELKIT-GDYDVEKLHPHGITAFEDKKTKK TFLLVINHHVR-FDVVDVFEFHRSSMSLSFIKSMRDPLMTSVNNLIATGPEEFYITNEAY FL--HPRMR-DLE-NFL-VMRMGSVLYCDVTGCK--KATESLNNPNGIDLSRDGRYLYVS QPFTRQVRIYKRDPSDNTLTANEGVHVIDLGTVADNVYVDE-SGDVWLGCLPVAHKALTY IDTKKGL---VPSQVLRVRVGPK--------DYELSEVYSEDGRNITVSTSAVHHKG--I LLIGSLHERMMRCQVNA----I >NP_491306.1 PON (paraoxonase) and MEC-6 Like [Caenorhabditis elegans] ---------------------MLVK--------VVLFGLLGV---SIHFIFN-TLLTLDI NKRVYNHRP--------GECRKIEGPVHGSEDIEVID---KLQIAFISS-----G-LVYL PN----SASDVKWKGQIFLYDLTKRSYK-AEPIPVL-NLEDVDGFHPHGLSHWIL-NNRT VRLFVVVHSKTFKHSIVILDYNSAKRELNHVKTIRGEKFVRPNDIVATGENSFLVSNDGG AQ--TALGN-VWE-ILS-GFYKGGLVYYNGKKSQ--FLMENNI-ANGIILSRDQKTLFVS HINQETIGVYTWNQKDGEIQK---ISEIETLTGCDNFYVDT-QDHLWAGCHPVVKDAAGH LGNVSDSTLYGPSQVLRVSFSKDLKTA------EIVEVLADDGRFVSASTIAIPFDDGKQ MIVGTVARPAIHCDINVSLNLY
BMGE Cleaned alignment of selected proteins >sp|Q15165|PON2_HUMAN Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 PE=1 SV=4 GLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-1|PON2_HUMAN Isoform 1 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 GLAGDRAGFLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >sp|Q15165-3|PON2_HUMAN Isoform 3 of Serum paraoxonase/arylesterase 2 OS=Homo sapiens OX=9606 GN=PON2 GLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDN------------EFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >tr|Q6NXA5|Q6NXA5_DANRE Paraoxonase OS=Danio rerio OX=7955 GN=pon2 PE=1 SV=1 LAVVAFAVLIGERLISLRHVALSYRELTQNYLPNCNFIEGIDFGAEDITIL-DGLAFLSTLKYPGVPSYSED-PGKIYTLNLLDSEQKIKVLHIRGDFDKDSFNPHGISVYTDKDGAIYLFVVNHPQGKSQVEIFRFLENENALEYLKTIRHELLHNVNDIVAVGTESFYATNDHYFTNDILKSLPWCDVVYYSPETVQVVAGGFLSANGINISPDKRHLYVSHILKHTIAVLEIQKNTVLSHVKEIDVGSLCDNIEVDRETGDLWIGCHPNGLKCVFHDPNDPPGSEVIRIENILSEKPQVTQVYSDDGSVIIASSVAAPYREKLLIGTVYQKALICDL >NP_001013606.1 serum paraoxonase/arylesterase 2 precursor [Bos taurus] SLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVLKCPGLHSFAPDKPGGILMMDLNEENPRALELRVSRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >NP_899131.1 serum paraoxonase/arylesterase 2 [Mus musculus] SLLGIGLALLGERFLALRSRLKASREVESVDLPNCHLIKGIETGAEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKDERPRALELRVSWGFDLASFNPHGISTFIDDDDTVYLFVVNHPQFKSTVEIFKFQEEENSLLHLKTIKHELLPSVNDIIAVGPTHFYATNDHYFSDPFLKNLHWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQRLFVYHPNHPPASEVLRIQNILSEKPSVTTVYINNGSVLQGSSVATIYDRKLLVGTLYQKALYCEL >NP_001003205.2 serum paraoxonase/arylesterase 2 precursor [Canis lupus familiaris] GLLGLALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGADDIDILPNGLAFFSVLKCPGLHSFSPDKPGGILLMDLKKENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPDEVKVVAEGFDAANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDILVGCHPNGQKLFIYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDRKLLIGTLYHRALYCEL >XP_519213.3 serum paraoxonase/arylesterase 2 isoform X1 [Pan troglodytes] GLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >NP_001116695.1 serum paraoxonase/arylesterase 2 precursor [Sus scrofa] SLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGSEDIDILPSGLAFFSVLKCPGLHSFAPDKPGGILMMDLKEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKQPNMNLTXLKVLELDTLVDNISIDPSSGDILVGCHPNGQKLFVYDANNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >NP_001119820.1 serum paraoxonase/arylesterase 2 precursor [Ovis aries] SLLGIALALLGERLLTLRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVLKCPGLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHYFSDPFLKNLRWTNVVYYSPNEVKVVVEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQDILSEKPTVTTVYANNGSVLQGSSAASVYDKKLLIGTLYHRALYCEL >XP_002713838.1 PREDICTED: serum paraoxonase/arylesterase 2 [Oryctolagus cuniculus] SVLGIALALLGERLLALRNRLKASREIESVDLPNCHLIKGIEAGSEDIDILPNGLAFFSVLKCPGLHSFAPDKPGGILMMDLKEERPRALELRISRGFDLASFNPHGISTFIDDDDTIYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIRHELLPSVNDVIAVGPAHFYATNDHYFSDPFLKNLHWANVIYYSPNEVKVVADGFDSANGINISPDKKYIYVADILAHEIHVLDKHSNMNLTQLKVLQLDTLVDNLSVDPSSGDIWAGCHPNGQKVYVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >XP_002818289.1 serum paraoxonase/arylesterase 2 [Pongo abelii] GLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGYDSANGINISPDNKYIYVADILAHEIHVLEKHPNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >XP_003809757.2 serum paraoxonase/arylesterase 2 isoform X1 [Pan paniscus] GLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >XP_023106134.1 serum paraoxonase/arylesterase 2 [Felis catus] SLLGIALALLGERLLALRNRLKASREVESVDLPNCHLIKGIEAGADDIDILPNGLAFFSVLKCPGLHSFSPDKPGGILMMDLKEENPRALELRISRGFNLASFNPHGISTFIDRDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPDEVKVVAEGFDAANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDIFVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDRKLLIGTLYHRALYCEL >XP_018886552.1 serum paraoxonase/arylesterase 2 isoform X1 [Gorilla gorilla gorilla] GLLGIALALLGERLLALRNRLKASREVESVDLPHCHLIKGIEAGSEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRARELRISRGFDLASFNPHGISTFIDNDDTVYLFVVNHPEFKNTVEIFKFEEAENSLLHLKTVKHELLPSVNDITAVGPAHFYATNDHYFSDPFLKNLHWANVVYYSPNEVKVVAEGFDSANGINISPDDKYIYVADILAHEIHVLEKHTNMNLTQLKVLELDTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDGKLLIGTLYHRALYCEL >XP_017902886.1 PREDICTED: serum paraoxonase/arylesterase 2 [Capra hircus] SLLGIALALLGERLLTLRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVLKCPGLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLASFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDVIAVGPEHFYATNDHYFSDPFLKNLRWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQDILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >XP_020738325.1 serum paraoxonase/arylesterase 2 [Odocoileus virginianus texanus] SLLGIALALLGERFLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >XP_043318581.1 serum paraoxonase/arylesterase 2 [Cervus canadensis] SLLGIALALLGERFLALRNRLKASREVESVDLPNCHLIKGIEAGAEDIDILPNGLAFFSVLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLLHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKFIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >NP_001013100.1 serum paraoxonase/arylesterase 2 [Rattus norvegicus] SLLGIGLALLGERFLALRSRLKASREVESVDLPNCRLIKGIETGAEDIDILPNGLAFFSVLKFPGLHSFAPDKPGGILMMDLKEEKPRALELRVSWGFDLASFNPHGISTFIDDDDTVYLFVVNHPEFKNTVEIFKFQEEENSLLHLKTIKHELLPSVNDVIAVGPSHFYATNDHYFSDPFLKNLRWANVVYYSPEEVKLVAEGFDSANGINISPDKKYVYVADILAHEIHVLEKQPNMNLTQLKVLQLGTLVDNLSIDPSSGDIWVGCHPNGQKLFVYDPNHPPSSEVLRIQNILSEKPSVTTVYINNGSVLQGSSVATIYDRKLLVGTLYQRALYCEL >KAB0375885.1 hypothetical protein FD755_012528 [Muntiacus reevesi] GDLGSIPGLSGERLG-YSLQKTKSATVSTVSLPDAMILGGVICISEVIDISPSSLCFFQPLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >KAB0344076.1 hypothetical protein FD754_021002 [Muntiacus muntjak] TFVGKVMSLLFNMLLVLEPRKTKSATVSTVSLPDAMILGGVICISEVIDISPSSLCFFQPLKCPSLHSFAPDKPGGILMMDLNEENPRALELRISRGFNLALFNPHGISTFIDSDDTVYLFVVNHPEFKNTVEIFKFEEEENSLWHLKTIKHELLPSVNDIIAVGPEHFYATNDHYFSDPFLKNLHWTNVVYYSPNEVKVVAEGFDSANGINISPDKKYIYVADILAHEIHVLEKHPNMNLTQLKVLKLDTLVDNLSIDPSSGDVLVGCHPNGQKLFVYDPKNPPSSEVLRIQNILSEKPTVTTVYANNGSVLQGSSVASVYDKKLLIGTLYHRALYCEL >NP_001188397.2 serum paraoxonase/arylesterase 2 precursor [Gallus gallus] ALVGIAAALAAERLLAFRNRLNATREVDPVALPNCHLIKGIETGSEDIDILPNGLAFISSLKYPGLKSFAPDKPGEIFLMDLNEKKPKASELRISRGFDLGSFNPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFMEDDNSLVHLKTIRHDLLTSVNDVVAVGPDSFYATNDHYFSDFILMGLTWSNVVYYSPKEVKEVAAGFYSANGINISPDKKYIYIADILDHNVHVMEKHADWNLTHVKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYDDPDNPPASEVLRIQNILAEQPTVTRVYAENGSVLQGTSVATVYDGKLLIGTVFHRALYCEL >XP_006258517.1 PREDICTED: serum paraoxonase/arylesterase 2 isoform X4 [Alligator mississippiensis] ALAGIAAAFLAGRFVAFRNKLNASREMEPVELPNCHLIKGIEAGAEDIDILPNGLVFISSLKYPGLKSFAPDKPGEILLMDLNEKNPKARELRISRGFDLASFNPHGISTYIDKDDSVYLFVVNHPHQKSTVEVFTFVEDDNSLKHLKTIKHDLLPSVNDILAVGPDGFYATNDHYFFDSVLMGLTWSNVVYYSPTEVKEVAGGFYSANGINMSPDEKYIYIADLLGHNIHVMEKHANWNLTQVKMLQLDTLIDNLFLDHSTGDIWAGCHPNGMKVFFYDPENPPGSEVLRIQNILSEKPLVSRVYAENGSVLQGSSVAAVHDGKLLIGTVFHKALYCEL >NP_001290116.1 serum paraoxonase/arylesterase 2 precursor [Meleagris gallopavo] ALIGIAAALAAERLLAFRNRLNATREVDPVALPNCRLIKGIEAGSEDIDILPNGLAFISSLKYPGLKSLAPDKPGEIFLMDLNEKKPKASELRISRGFDLGSFNPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFMEEDNSLLHLKTIRHDLLTSVNDVVAVGPDSFYATNDHYFYDFILMGLTWSNVVYYSPKEVKEVAAGFYSANGINISPDKKYIYIADIFDHNVHVMEKHADWNLTHVKTLQLDTLADNLSVDPDTGDIWTGCHPNGMKLFYNDPDNPPASEVLRIQNILAEQPTVTRVYAENGSVLQGTSVATVYNRKLLIGTVYHRALYCEL >XP_025064812.1 serum paraoxonase/arylesterase 2 isoform X2 [Alligator sinensis] --------------------------MEPVELPNCHLIKGIEAGAEDIDILPNGLVFISSLKYPGVKSFAPDKPGEILLMDLNEKNPKARELRISRGFDLASFNPHGISTYIDKDDSVYLYVVNHPHQKSTVEVFTFVEDDNSLKHLKTIKHDLLPSVNDLLAVGPDGFYATNDHYFFDSVLMGLTWSNVVYYSPTEVKEVAGGFYSANGINMSPDEKYIYIADLLGHNIHVMEKHANWNLTQVKVLQLDTLIDNLFLDHSTGDIWAGCHPNGMKVFLYDPENPPGSEVLRIQNILSEKPLVSRVYAENGSVLQGSSVAAVHDGKLLIGTVFHKALYCEL >XP_005504977.1 serum paraoxonase/arylesterase 2 [Columba livia] ----MRFSLKEHRLLRL-NRLNASREIAPVTLPNCRLIKGIEAGSEDIDILPNGLAFISSLKYPVLKNPELDKPGEIFLMDLNEDNPKAVELRISRGFDLASFVPHGISTYIDKDDTVYLFVVNHPHQKSTVELFKFVEDDNALVHVKTIRHDLLTSVNDVVAVGPDSFYATNDHYFFDHILMGLTWSNVVYYSPKEVKEVASGFYSANGINISPDRKYIYVADIFDHNIHVMEKHANWSLTHVKTVQLDTMVDNLSIDPHTGDVWLGCHPDGMKLVYNDPENPPGSEVLRIQNILSEEPVVTCVYSDNGSVLQGTSVASVYEGKLLIGTVFHRALYCEL >XP_043728287.1 serum paraoxonase/arylesterase 1 [Cervus elaphus] TLLGLGLAFFKDHRSSYLARMNASREVKSVELPNCKLIKGIETGAEDLEILHNGLAFISALRYPGIKSFEPDKPGKILLMDLNEEDPTVLELKMTSNFDASSFNPHGISTFTDEDNTVYLLVVSHPDFKSTVELFKFQEEEKSLLHLKTIKHELLPNLNDLVAVGPEHFYATNDHYFVDHYMRGLAWSNVVYYSPDDIRVVASGFDFANGISMSPDSKYVYIAELLAHKIHVYEKHANWTLTPLKSLDCNTLVDNLSVDPVTGDLWVGCHPNGMKIFSYDPENPPGSEVLQIQNILTEEPKVTVVYAEDGKVLHGSTVASVYKGKMLVGTVFHKALYCEL >XP_018122811.1 serum paraoxonase/arylesterase 2-like [Xenopus laevis] TLIGILLAFIGERIVQFCHRVNMNREVDPVDLPNCQLVKGIEFGSEDIEILPNGLAFISSLKFPGVMSLQPDKPSIIFLLDLNDEKLRPVSLRLSRGFDVSTFNPHGMSTYIDKDDTVYLFVVNHPQYKTTIELFKFEEEENALLHLKTIEHDLLWSINDIVAVGPESFYATNDLYFTDFTMKGIAWSNVVYYSPTEVKQVSSGYYYANGIAMSTDNKYIYVADIMGHTIDILEKQADWSLTPVKVLQLDSLVDNLFVDPNTGDLWTGAHPNGWKLFSYNSDDLPGSEVIRVQNIHSDNPIVTQVYVNNGSVIQASSSAAVYEGKLLIGTVFHKALCCEL >XP_040208238.1 serum paraoxonase/arylesterase 2-like [Rana temporaria] TLFGVFLAFLGERIVHFTDRINLVRDIEPVELPNCQLLAGIEYGSEDIEILPNGLAFISSLKYPGMFSFAPSRPGEIFLLDLNDEELRPSSLRISRGFDISSFSPHGISIYIDTDDTVYLFVVNHPHIKSTVEIFKFAEDENVLVHLKTIKHASLYNVNDLVAVGPESFYATNDHYFTDFILRGLRWTNVVYYSPSDIREVATGFYSANGIAMSNDERFIYVADVSGKAINVLEKHANFSLSPVKVLQLGALVDNLSVDPVTGDIWIGAHPNGFKLFKYSEEDPPGSEVIRVQNIHSDNPVVTTVYANDGSVLQASTCAAVWENNLLVGTIFHKALHCKL >KAF7225980.1 serum paraoxonase/arylesterase 2-like [Nothobranchius furzeri] IXVAVVAVLIGXRIINISKRYLAFREVTLNHLPNCVALKNLDHGTEDITILGHGLAFISTLKYPGVPS--GDVPGKIYTVDLNDPLLRPVELRMPRNFDLESFNPHGISIYIDSDDAVFLFVVNHPQHKSQVELFKYVEENRSLIHLKTIKHELLHSVNDIVAVGPESFYATNDHYFTNEILKLPPWTNVVYYSPKEVKVVSDGYTFANGINVSPDQKYIYVAAIFDHHVHVLERKEDNSLVPVKSVAVGSLCDNIEVEPETGDLWMGCHPNARKIFLFDPKDPPGSEVIRIQNIHSDHPVVTQVYADDGQVIMGSSVAAPYGGKLLIGSVFHKGLCCDL >XP_030250112.1 serum paraoxonase/arylesterase 2-like isoform X2 [Sparus aurata] IVVAALAALFGERVVNLRKRTLATRELVQNHLPNCVELKNLDYGSEDITILGNGLAFISTLKYPGLPS--QDVTAKLFVVDMKDSRKKPVELRMPRNFDLESFNPHGISLFTDSDDAVYLFVVNHPQHKSQVELFKFAEEDFSLLHLKTITHELLHSVNDIVAVGVDAFYATNDHYFSHHLLKVQPWCNVVYYSPEGVKVVSEGYYFPNGINLSPDKKHVYVVDLFDHNVHVLERKDDNGLVSVKSMHVGSLCDNVEVDPETGDLWLGCHPNAWKAFMLDPNDPPGSEVIRIQNIHSDKPAVTQVYADDGQVIVGSSVATTYEGKLLIGTVYHKALCCDL >XP_004077858.1 serum paraoxonase/arylesterase 2 [Oryzias latipes] AAVAAFAALFGRTFLKLKDISLASREIPVKRL-NCQYLKNIDYGAEDITILKDGLAFLSTLKYPGLHSFS-DEPGKMYVLDLLHPKMTPVELQIKGQLDLSSFNPHGISVYEDADDSIYVFVVNHPEHKSQVEIFRFVEED-TLMHLKTITHPLLHSVNDIVAVGAEHFYATNDHYFHHEALQDLSWCDVVYYSPHEVRVVAGGFKSANGINISPDRQYIYVSDIMDHEIDIFRRNEGEQLAYVKSVAVGSLCDNIEVDRRTGDIWLGCHPNGLKLLKFDPEDPPGSEVIRIKNIHSERPVVSLEYGDDGRQLIASTVAVPYEGKLLIGSVFHKALLCIL >XP_038044970.1 serum paraoxonase/arylesterase 2-like isoform X2 [Patiria miniata] ILIGISAALILQHILSVIYSLGFHKRAYNHRPGSCRVVTGIDSGSEDIHVLRNGLALITSIDLTPLDPSGLTWKGRIYLFDFKQPNANVTELPILGSFDHSDFRPHGISVWEET--QTTVFVVNHKQHREAIEVLSLNQDNKSLQYLYSITDPLMRSVNDVVAVGSNSFYFTNDGYNNQLFKRKFPWGNVIYYDGDAGRVVVSRGLEPNGINRSPDGRYIYVSSPIVGTVTVYEQQADHALQPIQVIDLSTSPDNIYVDSTSGDLWLGCHMIGYQSMLHNFTQPAASQVLHIQLNSKVAPDIREAYVDDGRQVSGSSVAAYYNKQLLIGSVAHKLAHCQV >CAE1156049.1 PON [Sepia pharaonis] ----------MQHIFSLVSMFLFKGTIHNHSPGPCKYVPGVENGAEDLHTLPNGLTFISSLTLD--NPDVPSVSGRILLYDMSQSGENAIELEI-ENFDQREFVPHGISAWVDKTGEITIFVVNHHKQRERIESFQYQPEKKTLLHLKTYKDGSMRHMNDVLATSNKTFYFTNWSHSKSLWGLLLPWTNVYYHDGEIYKLVAEDMVMANGLAMSADGKYVYVACTMTKDLKVFRRETDNSLTFHQEHLVDTLVDNPTVDE-NGDVWIGCHPKILPAWVYNPIYGAPSQVIKLEIQDGLVKSMKEVYANDGTMLAASTVASFYKNQTLIGSLREKLLLCDV >XP_031555871.1 serum paraoxonase/arylesterase 2-like [Actinia tenebrosa] LAVIVFVSSVIAHVFNTIVSFGYFKQVLGHSPGPCRAIN--VNGSEDVEILSNGMALFSSLRYTVQDPIINQRTGNIYLLDLNEHEPEPMIVTL-KSFNRSDFNPHGISIYEDTTGQVTFFVVNHKHNDQAVEIFSFDKKKKCMYHRRTVVDGKMYSPNDILAVGPESFYVTNDHYFHRPFLRIFLRSNVVYYDGSKSHLAVTGLVGPNGIIFDRSKRYVLVSAGFSNAIHVYKRQRDNSLLLSQKINIGTHADNINVDIDTGSFWIAGVPKGLDFAEYNLKHPAPSQVLNLRLNEERSGELREVYLNDGREHRGSTSAAHFRGKLLIGGIYDKMLMCEV >XP_001175598.3 serum paraoxonase/arylesterase 1-like [Strongylocentrotus purpuratus] LILVVLVAAVVRHVFTFLKVLGLEKTVYNHKPGNCQFVRGIEHGSEDLELLSDGIVIISELTFK--DRVEGAPRGHLFAYDINHHNNGATELKITGDYDVEKLHPHGITAFEDKTKKTFLLVINHHVRFDVVDVFEFHRSSMSLSFIKSMRDPLMTSVNNLIATGPEEFYITNEAYFLHPRMRVMRMGSVLYCDVTGCKKATESLNNPNGIDLSRDGRYLYVSQPFTRQVRIYKRDSDNTLTAVHVIDLGTVADNVYVDE-SGDVWLGCLPVAHKALTYTKKGLVPSQVLRVRVGPK---ELSEVYSEDGRNITVSTSAVHHKGILLIGSLHERMMRCQV >NP_491306.1 PON (paraoxonase) and MEC-6 Like [Caenorhabditis elegans] VVLFGLLGVSIHFIFNTLLTLDINKRVYNHRPGECRKIEGPVHGSEDIEVIDLQIAFISSLVYLPNSASDVKWKGQIFLYDLTKRSYKAEPIPVLNLEDVDGFHPHGLSHWILNNRTVRLFVVVHSKTKHSIVILDYNSAKRELNHVKTIRGEKFVRPNDIVATGENSFLVSNDGGAQTALGNGFYKGGLVYYNGKKSQFLMENNI-ANGIILSRDQKTLFVSHINQETIGVYTWNKDGEIQKISEIETLTGCDNFYVDT-QDHLWAGCHPVVKDAAGHNVSDSGPSQVLRVSFSKDLKTEIVEVLADDGRFVSASTIAIPFDDQMIVGTVARPAIHCDI
PhyML tree of selected proteins (XP_038044970_1_serum_paraoxonase_arylesterase_2_like_isoform_X2__Patiria_miniata_:0.51966166,NP_491306_1_PON__paraoxonase__and_MEC_6_Like__Caenorhabditis_elegans_:1.76415985,(CAE1156049_1_PON__Sepia_pharaonis_:1.17170162,(XP_001175598_3_serum_paraoxonase_arylesterase_1_like__Strongylocentrotus_purpuratus_:1.02306639,(XP_031555871_1_serum_paraoxonase_arylesterase_2_like__Actinia_tenebrosa_:0.87461863,(((((XP_005504977_1_serum_paraoxonase_arylesterase_2__Columba_livia_:0.15728546,(NP_001188397_2_serum_paraoxonase_arylesterase_2_precursor__Gallus_gallus_:0.0115305,NP_001290116_1_serum_paraoxonase_arylesterase_2_precursor__Meleagris_gallopavo_:0.02665669):0.05684108):0.05383037,(XP_006258517_1_PREDICTED__serum_paraoxonase_arylesterase_2_isoform_X4__Alligator_mississippiensis_:0.00000001,XP_025064812_1_serum_paraoxonase_arylesterase_2_isoform_X2__Alligator_sinensis_:0.0180895):0.12739993):0.06177383,(XP_043728287_1_serum_paraoxonase_arylesterase_1__Cervus_elaphus_:0.37439464,(((XP_002713838_1_PREDICTED__serum_paraoxonase_arylesterase_2__Oryctolagus_cuniculus_:0.04582371,(NP_001116695_1_serum_paraoxonase_arylesterase_2_precursor__Sus_scrofa_:0.01563103,(((NP_001013606_1_serum_paraoxonase_arylesterase_2_precursor__Bos_taurus_:0.00307599,((XP_020738325_1_serum_paraoxonase_arylesterase_2__Odocoileus_virginianus_texanus_:0.00000001,XP_043318581_1_serum_paraoxonase_arylesterase_2__Cervus_canadensis_:0.0030678):0.00274382,(KAB0344076_1_hypothetical_protein_FD754_021002__Muntiacus_muntjak_:0.02196871,KAB0375885_1_hypothetical_protein_FD755_012528__Muntiacus_reevesi_:0.03655917):0.1236993):0.00652087):0.00000001,(NP_001119820_1_serum_paraoxonase_arylesterase_2_precursor__Ovis_aries_:0.00617183,XP_017902886_1_PREDICTED__serum_paraoxonase_arylesterase_2__Capra_hircus_:0.00000001):0.01241989):0.0155279,(NP_001003205_2_serum_paraoxonase_arylesterase_2_precursor__Canis_lupus_familiaris_:0.01564693,XP_023106134_1_serum_paraoxonase_arylesterase_2__Felis_catus_:0.00626346):0.01579506):0.00832855):0.01564678):0.00335842,(NP_001013100_1_serum_paraoxonase_arylesterase_2__Rattus_norvegicus_:0.00963073,NP_899131_1_serum_paraoxonase_arylesterase_2__Mus_musculus_:0.02824232):0.07606453):0.00000001,(XP_002818289_1_serum_paraoxonase_arylesterase_2__Pongo_abelii_:0.00318172,((XP_003809757_2_serum_paraoxonase_arylesterase_2_isoform_X1__Pan_paniscus_:0.00000001,(XP_519213_3_serum_paraoxonase_arylesterase_2_isoform_X1__Pan_troglodytes_:0.00000001,(sp_Q15165_PON2_HUMAN_Serum_paraoxonase_arylesterase_2_OS_Homo_sapiens_OX_9606_GN_PON2_PE_1_SV_4:0.00000001,XP_018886552_1_serum_paraoxonase_arylesterase_2_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001,(sp_Q15165_3_PON2_HUMAN_Isoform_3_of_Serum_paraoxonase_arylesterase_2_OS_Homo_sapiens_OX_9606_GN_PON2:0.00000001,sp_Q15165_1_PON2_HUMAN_Isoform_1_of_Serum_paraoxonase_arylesterase_2_OS_Homo_sapiens_OX_9606_GN_PON2:0.01977185):0.00000001):0.00932505):0.02396761):0.1473733):0.06802774):0.11036067,(XP_018122811_1_serum_paraoxonase_arylesterase_2_like__Xenopus_laevis_:0.19184299,XP_040208238_1_serum_paraoxonase_arylesterase_2_like__Rana_temporaria_:0.26799697):0.104994):0.21055576,((XP_004077858_1_serum_paraoxonase_arylesterase_2__Oryzias_latipes_:0.3640575,tr_Q6NXA5_Q6NXA5_DANRE_Paraoxonase_OS_Danio_rerio_OX_7955_GN_pon2_PE_1_SV_1:0.32630342):0.13355286,(KAF7225980_1_serum_paraoxonase_arylesterase_2_like__Nothobranchius_furzeri_:0.16798346,XP_030250112_1_serum_paraoxonase_arylesterase_2_like_isoform_X2__Sparus_aurata_:0.19059634):0.11943594):0.11461505):0.91300487):0.13456502):0.10023912):0.10066996);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)