PB0204

DATABASE

Click here to access PB0204 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0204	P08253	72 kDa type IV collagenase	MMP2	CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1, matrix metallopeptidase 2	Homo_sapiens	Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Domains

Gene Ontology

PF00040 (3_fn2) PF00045 (4_Hemopexin) PF00413 (Peptidase_M10) PF01471 (PG_binding_1)

GO:0001968 (enables) fibronectin binding GO:0004175 (enables) endopeptidase activity GO:0004222 (enables) metalloendopeptidase activity GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0008233 (enables) peptidase activity GO:0008237 (enables) metallopeptidase activity GO:0008270 (enables) zinc ion binding GO:0016787 (enables) hydrolase activity GO:0046872 (enables) metal ion binding GO:0001525 (involved in) angiogenesis GO:0001541 (involved in) ovarian follicle development GO:0001542 (involved in) ovulation from ovarian follicle GO:0001553 (involved in) luteinization GO:0001666 (involved in) response to hypoxia GO:0001955 (involved in) blood vessel maturation GO:0001957 (involved in) intramembranous ossification GO:0006508 (involved in) proteolysis GO:0006979 (involved in) response to oxidative stress GO:0007162 (involved in) negative regulation of cell adhesion GO:0007507 (involved in) heart development GO:0007565 (involved in) female pregnancy GO:0007566 (involved in) embryo implantation GO:0007567 (involved in) parturition GO:0007568 (involved in) aging GO:0009314 (involved in) response to radiation GO:0009410 (involved in) response to xenobiotic stimulus GO:0009612 (involved in) response to mechanical stimulus GO:0014012 (involved in) peripheral nervous system axon regeneration GO:0014823 (involved in) response to activity GO:0016477 (involved in) cell migration GO:0022617 (involved in) extracellular matrix disassembly GO:0030163 (involved in) protein catabolic process GO:0030198 (involved in) extracellular matrix organization GO:0030335 (involved in) positive regulation of cell migration GO:0030574 (involved in) collagen catabolic process GO:0032502 (involved in) developmental process GO:0032526 (involved in) response to retinoic acid GO:0034097 (involved in) response to cytokine GO:0034614 (involved in) cellular response to reactive oxygen species GO:0035094 (involved in) response to nicotine GO:0035987 (involved in) endodermal cell differentiation GO:0042542 (involved in) response to hydrogen peroxide GO:0043065 (involved in) positive regulation of apoptotic process GO:0043627 (involved in) response to estrogen GO:0045906 (involved in) negative regulation of vasoconstriction GO:0048013 (involved in) ephrin receptor signaling pathway GO:0048661 (involved in) positive regulation of smooth muscle cell proliferation GO:0048705 (involved in) skeletal system morphogenesis GO:0048771 (involved in) tissue remodeling GO:0050896 (involved in) response to stimulus GO:0051602 (involved in) response to electrical stimulus GO:0055093 (involved in) response to hyperoxia GO:0060325 (involved in) face morphogenesis GO:0060346 (involved in) bone trabecula formation GO:0060740 (involved in) prostate gland epithelium morphogenesis GO:0071230 (involved in) cellular response to amino acid stimulus GO:0071345 (involved in) cellular response to cytokine stimulus GO:0071347 (involved in) cellular response to interleukin-1 GO:0071392 (involved in) cellular response to estradiol stimulus GO:0071492 (involved in) cellular response to UV-A GO:0071498 (involved in) cellular response to fluid shear stress GO:1904645 (involved in) response to amyloid-beta GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005739 (located in) mitochondrion GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0030017 (located in) sarcomere GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2 MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-2|MMP2_HUMAN Isoform 2 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLD PETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFA PGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGF LWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRW CGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCA TTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN LDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-3|MMP2_HUMAN Isoform 3 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIM INFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQP CKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICK QDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEE KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF GSIKSDWLGC >tr|Q6DG10|Q6DG10_DANRE 72 kDa type IV collagenase OS=Danio rerio OX=7955 GN=mmp2 PE=2 SV=1 MMSVKFFSCRHIVLKVFLVQFLASLQTFAAPSPIIKFPGDDTAHTDKEVALHYLNKFYGC PKDRCNLMVLKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGVPDVANYNFFHRKPKWG QKNVTYRILGHTPDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDGEADIMINFGRNEHGD GYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKYGNAEGEFCKFPFLFM GKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADGAPCKFPFTFQGD KYDSCTTSGRDDGYRWCATTEDYDKDKTYGFCPETAMSTSGGNSDGAPCVFPFKFLGDSY DSCTTSGRNDGKMWCAVTKSFDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGAL MAPIYTFTKTLRLSDDDVKGIQELYGEPTDKPLPTHTPPVTPMDVCNENIIFDAVAQIRG EIFFFKDRFLFRTADVRKKPTGPMLVATFWSELPEKIDAAYENPLEERTVFFAGDEMWVY SASTLEREYPKKISSMGLPSDLHGIDAAYSFHKTKKTYIFAGNKFWRYNEAKKKMDPGFP KIIADSWTAVPDDLDGALSLNGDGHSYFFKDSHYLKMDDSTLKIIKVGEVKKDWLRC
Selected proteins from model organisms >sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2 MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-2|MMP2_HUMAN Isoform 2 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLD PETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFA PGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGF LWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRW CGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCA TTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQD DIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRT VTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPL TSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDN LDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-3|MMP2_HUMAN Isoform 3 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANY NFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIM INFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADG EYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQP CKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMG LEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICK QDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEE KAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWR YNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKF GSIKSDWLGC >tr|Q6DG10|Q6DG10_DANRE 72 kDa type IV collagenase OS=Danio rerio OX=7955 GN=mmp2 PE=2 SV=1 MMSVKFFSCRHIVLKVFLVQFLASLQTFAAPSPIIKFPGDDTAHTDKEVALHYLNKFYGC PKDRCNLMVLKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGVPDVANYNFFHRKPKWG QKNVTYRILGHTPDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDGEADIMINFGRNEHGD GYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKYGNAEGEFCKFPFLFM GKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADGAPCKFPFTFQGD KYDSCTTSGRDDGYRWCATTEDYDKDKTYGFCPETAMSTSGGNSDGAPCVFPFKFLGDSY DSCTTSGRNDGKMWCAVTKSFDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGAL MAPIYTFTKTLRLSDDDVKGIQELYGEPTDKPLPTHTPPVTPMDVCNENIIFDAVAQIRG EIFFFKDRFLFRTADVRKKPTGPMLVATFWSELPEKIDAAYENPLEERTVFFAGDEMWVY SASTLEREYPKKISSMGLPSDLHGIDAAYSFHKTKKTYIFAGNKFWRYNEAKKKMDPGFP KIIADSWTAVPDDLDGALSLNGDGHSYFFKDSHYLKMDDSTLKIIKVGEVKKDWLRC >NP_032636.1 72 kDa type IV collagenase preproprotein [Mus musculus] MEARVAWGALAGPLRVLCVLCCLLGRAIAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRNDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSHDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFF KDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTS LGLPPDVQQVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGH SYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_112316.2 72 kDa type IV collagenase precursor [Rattus norvegicus] MEARLVWGVLVGPLRVLCVLCCLLGHAIAAPSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFF KDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTS LGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFPKLIADSWNAIPDNLDAVVDLQGGGH SYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_777170.1 72 kDa type IV collagenase precursor [Bos taurus] MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFV LKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQT VDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDD DELRTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEAL FTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPC VLPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFK DRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHS YFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_989751.1 72 kDa type IV collagenase preproprotein [Gallus gallus] MKTHSVFGFFFKVLLIQVYLFNKTLAAPSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDT LKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDA FARAFKVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELW TLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTKDFDADGKYGFCPHESLFTMG GNGDGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPF IFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAP IYTYTKNFRLSQDDIKGIQELYEVSPDVEPGPGPGPGPGPRPTLGPVTPELCKHDIVFDGVAQIRGEIFF FKDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQDEKAVFFAGNEYWVYTASNLDRGYPKKLT SLGLPPDVQRIDAAFNWGRNKKTYIFSGDRYWKYNEEKKKMELATPKFIADSWNGVPDNLDAVLGLTDSG YTYFFKDQYYLQMEDKSLKIVKIGKISSDWLGC >NP_999357.2 72 kDa type IV collagenase precursor [Sus scrofa] MTEARGARGALAGPLRALCVLGCLLSRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFV LKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKTQITYRIIGYTPDLDPET VDDAFARAFRVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDD DELWTLGEGQVVRVKYGNADGEYCKFPFSFNGKEYNSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEAL FTMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPC VFPFTFLGNKHESCTSAGRSDGKLWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGA LMAPIYTYTKNFRLSHDDVKGIQELYGASPDIDTGTGPTPTLGPVTPEICKQDIVFDGISQIRGEIFFFK DRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHS YFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_038316879.1 72 kDa type IV collagenase [Canis lupus familiaris] MQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFAR AFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLG EGQVVRVKYGNADGEYCKFPFLFNGREYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNA DGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFL GNKHESCTSAGRSDGKVWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYT YTKNFRLSQDDIKGIQELYGASPDAGTGTGPTPTLGPVTPEICKQDIVFDGISQIRGEIFFFKDRFIWRT VTPRNKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQ RVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGSGHSYFFKGAY YLKLENQSLKSVKFGSIKSDWLGC >NP_001159652.1 72 kDa type IV collagenase precursor [Ovis aries] MTEARVSRGALAAPLRALCVLGCLLGPAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFV LKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQT VDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDD DELWTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEAL FTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPC VFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFK DRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHS YFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_016785345.1 72 kDa type IV collagenase isoform X1 [Pan troglodytes] MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGSGHSY FFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_001075678.1 72 kDa type IV collagenase precursor [Oryctolagus cuniculus] MEALGARGALAGFLRALCVLGCLLGRATAPPSPVIKFPGDVAPKTDKELAVQYLNTFYGCPKDSCNLFVL KDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSNVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNADGQPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDAGTDAGTGPTPTLGPVTPEICTQDIVFDGIAQIRGEIFFF KDRFIWRTVTPGDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTS LGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPRLIADAWNAIPDHLDAVVDLQGSGH SYFFKGTYYLKLENQSLKSVKVGSIKTDWLGC >NP_001290134.1 72 kDa type IV collagenase precursor [Meleagris gallopavo] MKTHSVFGFVFKVLLIQVYLFNKTLAAPSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDT LKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDA FARAFKVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELW TLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTQDFDADGKYGFCPMSLFTMGG NGDGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFI FLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPI YTYTKNFRLSQDDIKGIQELYEVSPDVEPGPGPGPGPGPRPTLGPVTPELCKHDIVFDGVAQIRGEIFFF KDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQDEKAVFFAGNEYWVYTASNLDRGYPKKLTS LGLPPDVQRVDAVFNWGRNKKTYIFSGDRYWKYNEEKKKMELASPKFIADSWNGVPDNLDAVLGLTDSGY TYFFKDQYYLQMEDKSLKIVKMAR >NP_001098349.1 72 kDa type IV collagenase precursor [Oryzias latipes] MTTPIVRSCRGIVLKVFVLLFIVFQLSNARPSPIIRFPGDDTPKTDKEVALDYLNKFYGCPQDSCNLMVL KDTLKTMQKFFTLPETGEIDAQTVAIMKKPRCGVPDVANYNFFHNKPKWQKKDITYRILGYSPDLDEEVI NDAFYRAFKVWSDVTPLSFTRIMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGGGIGGDSHFDDD EQWTLGEGQVVKAKFGNADGEFCKFPFLFMGTEYKSCTAQGRDDGFLWCSTTYNFDEDGKYGFCPHELLF TLGGNGDGAPCKFPFTFQGKQYDSCTTEGRDDGYRWCATTEDYDRDTSYGFCPETAMSTVGGNGEGSPCV FPFTFLGDTYESCTTSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGAL MAPVYTFTKDFRLPQDDIQGIQELYGVPTDKPLPPTQGPVTPMDICKESIVFDAVAQIRGETFFFKDRFL FRSVNFRSKPKGPLLVATYWPDLPAKIDAAYENPAEEKTVFFAGNQFWVYRADELQSGYPRRLSNLDLPD DVQRIDAAFNFRRNRKTYLFSGDKFWRYDEDRKTMDPGFPKLIADSWNGIPDDLDSAFSLNGIDYSYFFK GNHYFKLEDNTLKIVKLGEIKTDWLGC >XP_024088998.1 72 kDa type IV collagenase [Pongo abelii] MEALMSRGALTGTLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGSGHSY FFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_008962127.2 72 kDa type IV collagenase [Pan paniscus] MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGSGHSY FFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_003998091.2 72 kDa type IV collagenase [Felis catus] MTEARGARGALAGPLRALCVLGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFV LKDTLKKMQKFFGLPQTGDLDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPET VDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDD DELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEAL FTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPC VFPFTFLGSKHESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA LMAPIYTYTKNFRLSHDDIKGIQELYGASPDIDTGTGPTPTLGPVTPEICKQDIVFDGISQIRGEIFFFK DRFIWRTVTPRSKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPPDVQRVDAAFNWSKNRKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHS YFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_004057705.3 72 kDa type IV collagenase isoform X1 [Gorilla gorilla gorilla] MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETV DDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALF TMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKD RFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLG LPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGSGHSY FFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_005504753.1 72 kDa type IV collagenase [Columba livia] MKTHIVCGFVFKVLLIQVYLLNKTLAAPSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDT LKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDA FARAFQVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELW TLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRSDGFLWCSTTKDFDADGKYGFCPHESLFTMG GNGEGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPF IFLGNKYESCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAP IYTYTKNFRLSQDDIKGIQELYEVSPDVEPGPGPGPGPRPTLGPVTPELCKHDIVFDGVAQIRGETFFFK DRFMWRTVNPRAKPTGPLLVATFWPDLPEKIDAVYEAPQDEKAVFFSGNEYWVYSASNLERGYPKKLTAL GLPPDVQRVDAAFNWGRNKRTYIFAGDRYWKYNEEKKKMEIASPKFIADSWNGVPDNLDAVLGLGDSGYT YFFKDQYYLQMEDKSLKIVKIGKINSDWLGC >XP_005692042.2 PREDICTED: 72 kDa type IV collagenase [Capra hircus] MTEARVSRGALAAPLRALCVLGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFV LKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQT VDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDD DELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEAL FTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPC VFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGA LMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFK DRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHS YFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_006019137.1 72 kDa type IV collagenase [Alligator sinensis] MKTHVIFTPFGFIFKVLLIQQHIFYQTLAAPSPIIKFPGDSPPKTDKELAVQYLNTFYGCPKDNCNLFVL KDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNLVTYRILGYTPDLDPETV DDAFGRAFKVWSDVTPLKFSRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLF TMGGNGEGQPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGAL MAPIYTYTKNFRLSQDDIQGIQELYGGSTDVGPGPGPGPSPTLGPVTPEICKNDIIFDGVAQIRGETFFF KDRFMWRTVNPRNKPTGPLLVATFWPDLPDKIDAVYEAPQEEKTIFFSGNEYWVYSASNLERGYPKKLTN LGLPPDVQRVNAAFNWGRNKKTYIFAGEKFWKYNEEKKKMEPGFPKFIADSWNGIPDNLDAVLSPSDSGY SYFFKERYYLKMEDTSVKIIQIGNIKSDWLGC >XP_006273079.1 PREDICTED: 72 kDa type IV collagenase [Alligator mississippiensis] MKTHVIFTPFGFIFKVLLIQQHIFYQTLAAPSPIIKFPGDSPPKTDKELAVQYLNTFYGCPKDNCNLFVL KDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNLVTYRILGYTPDLDPETV DDAFGRAFKVWSDVTPLKFSRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDD ELWTLGEGQVVRVKYGNADGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLF TMGGNGEGQPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCV FPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGAL MAPIYTYTKNFRLSQDDIQGIQELYGGSTDVGPGPGPGPSPTLGPVTPEICKNDIIFDGVAQIRGETFFF KDRFMWRTVNPRNKPTGPLLVATFWPDLPDKIDAVYEAPQEEKTIFFSGNEYWVYSASNLERGYPKKLTN LGLPPDVQRVNAAFNWGRNKKTYIFAGEKFWKYNEEKKKMEPGFPKFIADSWNGIPDNLDAVLSPSDSGY SYFFKERYYLKMEDTSVKIIQIGNIKSDWLGC >XP_015808328.1 PREDICTED: 72 kDa type IV collagenase [Nothobranchius furzeri] MGFPTIVNCRRLVLKVCLLQLIAFLTANARPSPIIRFPGDDSPTTDKEVALHYLNKFYGCPQDRCNLMVL KDTLKKMQKFFALQETGEIDDKTVEVMKKPRCGVPDVANYNFFHRKPKWQKKDITYRILGYSLDLDEEVI NDAFFRAFKVWSDVTPLTFTRIMDGEADIMVNFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDD EQWTLGEGQVVKAKFGNADGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDSKYGFCPHELLF TLGGNGDGAPCKFPFTFQGEKYDSCTTAGRDDGYRWCATTEDYDRDKSYGFCPETAMSTVGGNADGSPCA FPFTFLGDSYDSCTSSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGAL MAPIYTFTKDFRLSHDDVQGIQELYGVPTDKPVSPTQGPVTPMDICREPVIFDAVAQIRGETFFFKDRFL FRSVNFRSKPNGPMLVATYWPDLPAKIDAAYENPVDEKTVFFAGNEMWIYKADELERGYPKRLSSLGLPS DLQQIDAAFNFRKNRKTYLFSGDQFWRYDEDRATMDPGFPKPIAESWNGVPDGIDAAFSLNGIDYSYFFK GNHYFKLEDSSLKIIKLGEITKDWLGC >XP_020756186.1 72 kDa type IV collagenase [Odocoileus virginianus texanus] MINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLF NGKEYTSCTDTGRTDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEG RTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTS NYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP DIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEK IDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPSDVQKVDAAFNWSKNKKTYIFAGDKFW RYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLG C >XP_030269668.1 72 kDa type IV collagenase [Sparus aurata] MGSPTIFSCRRIVLKVFLLQFIAFQATYAAPSPIIRFPGDDTTPKTDKEVALHYLNKFYGCPQDRCNLMV LKDTLKKMQKFFSLQETGEIDAKTVDIMKKPRCGVPDVANYNFFHRKPMWQKKDVTYRILGYTPDLDEEV INDAFFRAFKVWSDVTPLSFTRLMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDD DEQWTLGDGQVVKVKFGNADGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDGKYGFCPHELL FTLGGNAEGAPCKFPFNFQGEKYDSCTTSGRDDGYRWCATTEDYDRDKSFGFCPETAMSTVGGNAEGSPC VFPFTFLGDTYESCTTSGRSDGKMWCAASKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGA LMAPIYTYTKDFRLSQDDIKGIQELYGVSGDRPSSPTQGPVTPMDICKEPVIFDAVAQIRGETFFFKDRF LFRSVNFRSKPNGPMLVATYWPDLPSKIDAAYENPVDEKTVFFAGNEMWVYKADELEKGYPKRLSSLELP TDLQKIDAVFNFRKNRKTYLFSDDKFWRYDEDSKRMDPGFPKLIADSWNGIPDGIDAAFSLNNIDYSYFF KGDHYFKLEDSSLKIVKLGEITKDWLGC >XP_040184680.1 72 kDa type IV collagenase [Rana temporaria] MKCIQAIHLCAFYFQFFDLIDQNTAAPSPIIKFPGDTSPKTDKELVTQYLLKYYGCPKDGCIMVLKDTLK KMQKFFHISETGEIDQKTIDTMKKPRCGNPDVSNYQFFPRKPKWEKNHITYRILGYTTDLDSETVDDAFA RAFQVWSDVTPLKFNRLKDGDADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGSGIGGDSHFDDDELWTL GEGQVVKVKYGNADGEFCKFPFKFNDKEYNSCTDAGRNDGFIWCSTTYDFDKDQKYGFCPHELLFTLAGN ADGKPCKFPFKFQGNTYDSCTTEGRTDGYRWCATTEDYDKDTTYGFCPETTLSTVGGNSDGSPCVFPFTF LGNNYNSCTSTGRSDGKLWCATTSNYDNDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGALMAPIY TYTKNFRLSQDDISGIQDLYGRGEGKEPRPGPDPYPTEGPVTPDLCTSDIVFDGISQIRGEIFFFKDRFI WRSVNRREKPSGPLLVATFWSELPEKIDAVYEDPEEEKTVFFAGDEYWIYSTSALERGYPKKLTNLGLPP DLKRVDAAFNWGRNKKTYLFAGDKFWRYNEAKKKMDPGFPKLIADSWNGVHDNLDAVVDVRGSGYSYFFK DQYYHEMEDRILKIVKVGNIKNDWLSC >KAB0351673.1 hypothetical protein FD754_016530 [Muntiacus muntjak] MTEARVSRGALAAPLRALCVLGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQK FFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRF SRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLF NGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGT TEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFL VAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGIS QIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLK LENQSLKSVKFGSIKSDWLGC >XP_043290763.1 72 kDa type IV collagenase [Cervus canadensis] MTEARVSRRALAAPLRALCVLGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQK FFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRF SRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLF NGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGT TEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFL VAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGIS QIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSL GLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVLDLQGGGHSYFFKGAYYLK LENQSLKSVKFGSIKSDWLGC >OWK15608.1 MMP2 [Cervus elaphus hippelaphus] MQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTP LRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFP FLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRW CGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYS LFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFD GISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPL TSLGLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVLDLQGGGHSYFFKGAY YLKLENQSLKSVKFGSIKSDWLGC >NP_001080697.1 72 kDa type IV collagenase [Xenopus laevis] MRTIKIINVLVLIFNSFSIFYYVSPAPSPIIKFPGDKSPKTDVELAAQYLNQFYGCPKEKCHLMVLKDALKKMQSFFGLP ETGEFDQNTIETMKKPRCGNPDVANYNFFPRKPKWDKNHLTYRILGYTTDLDSETVDDAFARAFKVWSDVTPLEFNRIHD GEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGSGVGGDSHFDDDELWTLGEGQVVKVKYGNADGEFCNFPFLFNDKEY NSCTDSGRSDGFLWCSTTYDFDKDGKYGFCPHELLFTLTGNAEGKPCKFPFKFQGNTYNSCTTEGRTDGYRWCATTEDYD KDKMYGFCPETALSTVGGNAEGSPCVFPFTFLGNKYDSCTSSGRSDGKLWCASSSNYDDDRKWGFCPDQGYSLFLVAAHE FGHALGLEHSQDPGALMAPIYTYIKNFRLSQDDITGIQELYGQGSKEKPGPGPIPTMGPVTPDLCSKDVVLDGMSQIRGE TFFFKDRFIWRTPNIRNKPSGPLLIATFWPELPDKIDAVYEEPQEEKTVFFAGNEYWVYSSSTLERGYPKKLTSLGLPPD VDRVDAAFNWSKNKKTYFFAGDKFWRYNEVKKKMDTGFPKLIADAWNGVPDNLDAVLDQTGSGYSYFFKDWYYFQVEGKS VKIVKVGNVKNDWLRC >XP_039256683.1 72 kDa type IV collagenase-like [Styela clava] MYKYSRTVITGLLCFALLVCYCNARPRNRHGGAPGFRAPKFMRSTSYGRKQENKFRLGVDNTGLIQGWTIKSPYQQSRLR SEAEPIQYISPRAQLNGNFGKSPAAPQRLGRRQYIPKHFEAPEAGLESAPHALKIMTESQKNAIAQEFFLKYKYAKENAL NDKGDMIRTVQRNYGLNITGELNDETVVAMMRPRCGVPDAPAEYNLFPNREHWTHKDITYKIEGYTPDMSQCQIRNAFKR AFRVWEEVTDLNFEKVDRDDADIIIYFGYEEHGDGYPFDGPNGLLAHAFTPGTTAISGDSHFDEGEFWTLGKGRVFDTYN GNSGGDPCVFPFYFEGASYSACTSAGRSDGLEWCATTADYDADEKWAFCPHELLFTYAGNGDNDPCVFPFVFLGKSYDEC TPEGRSDGYLWCATTSNYDTDSRWGFCPSRAHGTDGGNSGGAACTFPFKFEGYTYVDCTTVGRTDYKLWCATTDDYDKDG MWGFCNGEGYSLFLVATHEFGHAIGLDHSNVADALMYPMYSYHADFILPDDDKRGVRDLYGPRRRYLPPLQLETCGGDLT KSEPTATRPPRTSTPTVTPRTTPRGRTSTPTQSTTTHSGDRCDGVVPPTDMCQRKVDAVMLYQNEFFVFQGPFVWRVSGR GKNQVQTPERISNHWPTLKCGIDGVYQNPIDLKLMFFKGSQYFLFDGENILPGYPREVTELGLPARTVVDDVVFMKGRNP KTRRTENRLYYYVREKVYRADPKTGILMEGFKPSTLGVKGTAWEGIPPNIDAVFSDAQNRRYTIFVKGMKIFRYMNVRGQ LDYSRGFKKFFTCPIKVEEFIPLPLRE >XP_030848086.1 matrix metalloproteinase-24 [Strongylocentrotus purpuratus] MDEETRRLMSYPRCGMPDVIPNGDPGQTRFRRYSDSGDKWDHQEITYRILNFTPDLTEAEVVDSFERAFKVWSDVTPLTF RRVFDVPGDIHIQFSEYDHGDGVAFDGLGGTLAHAYFPGGSIGGDAHFDDSEIFSVFLSDDDKTDLFMVAAHEFGHSLGL GHSSDIHALMAPFYVGYDPGFSLGYDDLHGIQSIYGINSSPRPGDRFIPLRPQPSPPDPEVERCSKSFNAVAFIRNELFL FKGKNFWRMREQGKPLEGYPVEMGQFWHGLPPKVDASYERHDGKIVFLKGSHYWVYEGVDMDPDYPRPLRELGLPADIDG ALPWGQTGKTYFFKGDVYYRYDEFDHRMDKGYPKLIKENWLGVPINIDAVFRHYDGYSWNTYFIRHRRYWQFDESRGQVD LGFPRNFGVDWMGCKEEDAKVDQPEGPGQLRAEVTMISSMTTENSSPLTLSHSSLCLCLSISFALLLNRS >XP_038075032.1 collagenase 3-like [Patiria miniata] MDATHVPNQTQRTWNIQNRRAMNAAWTCVVRLSLGLVLLLGPYITQAAPTSTLLPGEGDAGPENLVTPGQLRTGFNYLTK YGFLPKPNPVAGSLRSQAEFYDGIRAFQTFYGLPVTGALDGRTEALMAMPRCGLPDIMRDDDGSRKRRYVHTGATWDHQD LTYRMKNYSPDLTRSEIDEAIAGALKIWSDVIPLNFEKREMGPADIDISFARGLHHDDYPFDGPGGTLAHAFFPGDDLGG DAHFDDDEQFTVKSYEGTNLLIVAAHEFGHSLGFGHSSDLTALMAPFYQGYKPNYVLPYDDHVGAQHLYGARPGSVPSRG ESPGGEAPGPPADPTSPPDQNPTCGGSYNAIAKIRGELMLFKGKTFWRMLEKGHPLEGYPIDTSRFWDQLPVKVDAAYER IDDKILFFKGASYWEYTGTDRDPSFPRPIRELGLPDDIDAALPWGETGKTYFFRGDQYWRYDEMERQVDTGYPKEVKEKW DADVPSNMDTAFRFVDENGLWYTYFVRNKKYWRFDESRGKVDKGFPRSFDVDWMGCPEPANNLVSTDETDIVVEPPKTEK MTGSGANPTRGFCYKAHIFLLVLLTWMLMG >XP_031568071.1 stromelysin-2-like isoform X2 [Actinia tenebrosa] MSGPQTRPREGKDATYFMDQNGKKKDLTYKILNYSPDLSRKEIDDTIRDAFNVWAAVTPLTFKKVNSGKADIDIKFATYE HGDGYPFDGRGQTLAHAFYPQDNSEDIYGDAHFDDDEPFTLKGKRGIDLFWVAVHEFGHSLGLDHSNHLDAIMYPFYGGY KADFKLHSDDVNGIQAIYGKPTSPSQSTLAPTPTGRVTPTPHTRTDAPGVPDKCSSPVDAFVTTEAGLTYAFKGEYFWPI AESGSWTSALKIADFWPLVEDNVDAAFLRRSDKVNFIFKGDKFWMLKDRSALKSKPLPITDPELNLPADLANMDAAFQWG RNNKVYFFKGDKYWRYDPDRKEIDIGYPKLITDGWRXNIPYNLDAALQWENGKTYFFKGLEYFAIDDYTLEIPKVDPPYP RKISTYWMGCSPEGVIGGKISPVESSAFTFLPXLVATVSTLILAKLL >KAG6797835.1 Matrix metalloproteinase-14 [Apis mellifera caucasica] MTLPRCGVKDKVGPGFGRSKRYALQGSRWRVKKLSYKISKYPRNLPQHKVDAELNKAFKVWSEYTDLVFVQKKSGQVHIE IRFEKGEHGDGDPFDGPGGTLAHAYFPVYGGDAHFDDAEQWTIDSFRGTNLFQVAAHEFGHSLGLSHSDVKSALMAPFYR GYEPYFRLDEDDIQGIQALYGTKTSNNGGVPSGPKPTTTASPSEEDSELCTNSKVDTMFNSAEGHMYVFKGDRYWRLTSD GVAIGYPKLISHSWKGLPGNIDAAFTYKNGKTYFFKGSKYWRYVGKKMDGDYPKEISEGFTGIPDNIDTVTVWTGNGKLY FYKGSKFWRFDPSQKPPVKNTYPKLISNWEGLPDNLDASIVYRGYTYFFKGDAYYRFNDRTFSVDIADPAFPRSTAYWWF GCRSANKGTLGNGSMNRWYNSQCNGNECLWFPENAINTFLNGGDFFIPDSVDGDNNDVGDIILDAGIKASFESDQILTSP >NP_001189004.1 matrix metalloproteinase 1, isoform J [Drosophila melanogaster] MTNCQSSVFIVVGTLFSIMAAAQSAPVSTTTQAEIYLSQFGYLPASARNPASSGLHDQRTWVSAIEEFQSFAGLNITGEL DAETMKLMSLPRCGVRDRVGTGDSRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKT SGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFPVFGGDAHFDDAELWTIGSPRGTNLFQVAAHEFGHSLGLSHSDQSSA LMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQLRPTNVYPATTQRPYSPPKVPLDDSICKDSKVDTLFNSAQGETYAFK GDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYKNGKTYFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHLDAA MVWGGNGKIYFFKGSKFWRFDPAKRPPVKASYPKPISNWEGVPNNLDAALKYTNGYTYFFKGDKYYRFHDARFAVDSATP PFPRPTAHWWFGCKNTPSSTGFKRRGYKNKNN >CAE1318974.1 MMP14 [Sepia pharaonis] MKQWRLNRIRSVHRNYDLLNSSVKMNEPEALSDFLRWVERTRHSGPNELFSARLGRTNCSLPAWVERTVLCLPGSNELFS ARLGSKWAKRDLTYKIQQVTPRLPRLKVEREIARAFKVWSEVTSLTFTQKDMDPVDIEVLFARNHHGDRHPFDGSGGTLA HAFFPQFGGDAHFDDSESWSVASRQGVNLFQVAAHEIGHSLGLAHSDVRNALMAPFYRGYIPNFKLSRDDVAAVQELYGG RTDTRRFDPPPNPLPTQGRVSRPPICNDASIDAITRLRDGTTHVFKGEEYYRLSRTGIDNGYPRKIHWDWRGVQGPIDAA VTWDDSFTFIFKDDKYWKFDGMKPVSGYPRKIREGFKGLPDKIDAAFVWSGNGKTYFIKGDRYWRWAKYGIDFGYPKQLN VWVNLPPRVTAAFKWQNGRTYFFNGDTYYRFNDKNFRVDDDYPRKVSYWWLGCADETQNQQVHDVHSVITTRPRYPDKPR TVHVSPTQDKDKDWKVIRKGNDNGGLRMQATRLMLAGSLFVAFLRHQ
Mafft alignment of selected proteins >sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2 -MEALM----------------ARGALTGPLRAL-------------------------- -----------------CLLGCLL--------SHAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >sp|P08253-2|MMP2_HUMAN Isoform 2 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >sp|P08253-3|MMP2_HUMAN Isoform 3 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------MQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >tr|Q6DG10|Q6DG10_DANRE 72 kDa type IV collagenase OS=Danio rerio OX=7955 GN=mmp2 PE=2 SV=1 -MMSVK----------------FFSCRHIVLKVF-------------------------- -----------------LVQFLAS--------LQTFAAP----SPIIKFPGDD------- ------------------------------TAHTDKEVALHYLNKFYGCPKDRCNL---- ----MVLKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGVPDV------------ANYN FFHRKPKWGQKNVTYRILGHTPDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDGEADIMI NFGRNEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDEQWTLGEGQVVKVKYGNA EGEFCKFPFLFMGKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADG APCKFPFTFQGDKYDSCTTSGRDDGYRWCATTEDYDKDKTYGFCPETAMSTSGGNSDGAP CVFPFKFLGDSYDSCTTSGRNDGKMWCAVTKSFDDDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSDDPGALMAPIYT-FTKTLRLSDDDVKGIQELYGEPTDK---------------- --------------------------PLP--THTPPVTPM------------DVCNENII FDAVAQIR-GEIFFFKDRFLFRTADVRKK-PTGPMLVATFWSELPEKIDAAYENPLEERT VFFAGDEMWVYSASTLEREYPKKISS--MGLPSDLHGIDAAYSFHKTKKT-------YIF AGNKFWRYNEAKK-KMDPGF-PKII---ADSW-TAVPDDLDGALSLNGD---GHSYFFKD SHYLKMDDSTLKIIKV-----GEVKKDWLRC----------------------------- ---------------------------------------------------------- >NP_032636.1 72 kDa type IV collagenase preproprotein [Mus musculus] -MEARV----------------AWGALAGPLRVL-------------------------- -----------------CVLCCLL--------GRAIAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRNDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIKGIQELYGPSPDA---------------- -----------------DTDTG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQQVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADSW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_112316.2 72 kDa type IV collagenase precursor [Rattus norvegicus] -MEARL----------------VWGVLVGPLRVL-------------------------- -----------------CVLCCLL--------GHAIAAP----SPIIKFPGDV------- ------------------------------SPKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDG QPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSNDDIKGIQELYGPSPDA---------------- -----------------DTDTG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQQVDAAFNWSKNKKT-------YIF SGDKFWRYNEVKK-KMDPGF-PKLI---ADSW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_777170.1 72 kDa type IV collagenase precursor [Bos taurus] MTEARV----------------SRGALAALLRAL-------------------------- -----------------CALGCLL--------GRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELRTLGEGQVVRVKYGNA DGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAP CVLPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPGVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_989751.1 72 kDa type IV collagenase preproprotein [Gallus gallus] -MKTHS----------------V---FGFFFKVL-------------------------- -----------------LIQVYLF--------NKTLAAP----SPIIKFPGDS------- ------------------------------TPKTDKELAVQYLNKYYGCPKDNCNL---- ----FVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFKVWSDVTPLRFNRINDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTKDFDADGKYGFCPHESLFTMGGNGDG QPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFIFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIKGIQELYEVSPDVEP-------------- ---------------GPGPGPG----PGP-RPTLGPVTP-------------ELCKHDIV FDGVAQIR-GEIFFFKDRFMWRTVNPRGK-PTGPLLVATFWPDLPEKIDAVYESPQDEKA VFFAGNEYWVYTASNLDRGYPKKLTS--LGLPPDVQRIDAAFNWGRNKKT-------YIF SGDRYWKYNEEKK-KMELAT-PKFI---ADSW-NGVPDNLDAVLGLTDS---GYTYFFKD QYYLQMEDKSLKIVKI-----GKISSDWLGC----------------------------- ---------------------------------------------------------- >NP_999357.2 72 kDa type IV collagenase precursor [Sus scrofa] MTEARG----------------ARGALAGPLRAL-------------------------- -----------------CVLGCLL--------SRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKTQITYRIIGYTPDLDPETVDDAFARAFRVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFSFNGKEYNSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSHDDVKGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------EICKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_038316879.1 72 kDa type IV collagenase [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGREYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKVWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DAGTG----TGP-TPTLGPVTP-------------EICKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRNK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGS---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_001159652.1 72 kDa type IV collagenase precursor [Ovis aries] MTEARV----------------SRGALAAPLRAL-------------------------- -----------------CVLGCLL--------GPAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_016785345.1 72 kDa type IV collagenase isoform X1 [Pan troglodytes] -MEALM----------------ARGALTGPLRAL-------------------------- -----------------CLLGCLL--------SHAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGS---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_001075678.1 72 kDa type IV collagenase precursor [Oryctolagus cuniculus] -MEALG----------------ARGALAGFLRAL-------------------------- -----------------CVLGCLL--------GRATAPP----SPVIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKDSCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSNVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASPDA---------------- -----------------GTDAG----TGP-TPTLGPVTP-------------EICTQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPGDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PRLI---ADAW-NAIPDHLDAVVDLQGS---GHSYFFKG TYYLKLENQSLKSVKV-----GSIKTDWLGC----------------------------- ---------------------------------------------------------- >NP_001290134.1 72 kDa type IV collagenase precursor [Meleagris gallopavo] -MKTHS----------------V---FGFVFKVL-------------------------- -----------------LIQVYLF--------NKTLAAP----SPIIKFPGDS------- ------------------------------TPKTDKELAVQYLNKYYGCPKDNCNL---- ----FVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFKVWSDVTPLRFNRINDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTQDFDADGKYGFCPM-SLFTMGGNGDG QPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFIFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIKGIQELYEVSPDVEP-------------- ---------------GPGPGPG----PGP-RPTLGPVTP-------------ELCKHDIV FDGVAQIR-GEIFFFKDRFMWRTVNPRGK-PTGPLLVATFWPDLPEKIDAVYESPQDEKA VFFAGNEYWVYTASNLDRGYPKKLTS--LGLPPDVQRVDAVFNWGRNKKT-------YIF SGDRYWKYNEEKK-KMELAS-PKFI---ADSW-NGVPDNLDAVLGLTDS---GYTYFFKD QYYLQMEDKSLKIVKM-----AR------------------------------------- ---------------------------------------------------------- >NP_001098349.1 72 kDa type IV collagenase precursor [Oryzias latipes] -MTTPI----------------VRSCRGIVLKVF-------------------------- -----------------VLLFIVF--------QLSNARP----SPIIRFPGDD------- ------------------------------TPKTDKEVALDYLNKFYGCPQDSCNL---- ----MVLKDTLKTMQKFFTLPETGEIDAQTVAIMKKPRCGVPDV------------ANYN FFHNKPKWQKKDITYRILGYSPDLDEEVINDAFYRAFKVWSDVTPLSFTRIMDGEADIMI NFGRNEHGDGYPFDGKDGLLAHAFAPGG---GIGGDSHFDDDEQWTLGEGQVVKAKFGNA DGEFCKFPFLFMGTEYKSCTAQGRDDGFLWCSTTYNFDEDGKYGFCPHELLFTLGGNGDG APCKFPFTFQGKQYDSCTTEGRDDGYRWCATTEDYDRDTSYGFCPETAMSTVGGNGEGSP CVFPFTFLGDTYESCTTSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSQDPGALMAPVYT-FTKDFRLPQDDIQGIQELYGVPTDK---------------- --------------------------PLP--PTQGPVTPM------------DICKESIV FDAVAQIR-GETFFFKDRFLFRSVNFRSK-PKGPLLVATYWPDLPAKIDAAYENPAEEKT VFFAGNQFWVYRADELQSGYPRRLSN--LDLPDDVQRIDAAFNFRRNRKT-------YLF SGDKFWRYDEDRK-TMDPGF-PKLI---ADSW-NGIPDDLDSAFSLNGI---DYSYFFKG NHYFKLEDNTLKIVKL-----GEIKTDWLGC----------------------------- ---------------------------------------------------------- >XP_024088998.1 72 kDa type IV collagenase [Pongo abelii] -MEALM----------------SRGALTGTLRAL-------------------------- -----------------CLLGCLL--------SHAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGS---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_008962127.2 72 kDa type IV collagenase [Pan paniscus] -MEALM----------------ARGALTGPLRAL-------------------------- -----------------CLLGCLL--------SHAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGS---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_003998091.2 72 kDa type IV collagenase [Felis catus] MTEARG----------------ARGALAGPLRAL-------------------------- -----------------CVLGCLL--------GRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGSKHESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIKGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------EICKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRSK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNRKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_004057705.3 72 kDa type IV collagenase isoform X1 [Gorilla gorilla gorilla] -MEALM----------------ARGALTGPLRAL-------------------------- -----------------CLLGCLL--------SHAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGT---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSQDDIKGIQELYGASP------------------ -----------------DIDLG----TGP-TPTLGPVTP-------------EICKQDIV FDGIAQIR-GEIFFFKDRFIWRTVTPRDK-PMGPLLVATFWPELPEKIDAVYEAPQEEKA VFFAGNEYWIYSASTLERGYPKPLTS--LGLPPDVQRVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGS---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_005504753.1 72 kDa type IV collagenase [Columba livia] -MKTHI----------------V---CGFVFKVL-------------------------- -----------------LIQVYLL--------NKTLAAP----SPIIKFPGDS------- ------------------------------TPKTDKELAVQYLNKYYGCPKDNCNL---- ----FVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFNRINDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFWFNGKEYNSCTDAGRSDGFLWCSTTKDFDADGKYGFCPHESLFTMGGNGEG QPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFIFLGNKYESCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIKGIQELYEVSPDVE--------------- ----------------PGPGPG----PGP-RPTLGPVTP-------------ELCKHDIV FDGVAQIR-GETFFFKDRFMWRTVNPRAK-PTGPLLVATFWPDLPEKIDAVYEAPQDEKA VFFSGNEYWVYSASNLERGYPKKLTA--LGLPPDVQRVDAAFNWGRNKRT-------YIF AGDRYWKYNEEKK-KMEIAS-PKFI---ADSW-NGVPDNLDAVLGLGDS---GYTYFFKD QYYLQMEDKSLKIVKI-----GKINSDWLGC----------------------------- ---------------------------------------------------------- >XP_005692042.2 PREDICTED: 72 kDa type IV collagenase [Capra hircus] MTEARV----------------SRGALAAPLRAL-------------------------- -----------------CVLGCLL--------GRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPPDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_006019137.1 72 kDa type IV collagenase [Alligator sinensis] -MKTHV----------------IFTPFGFIFKVL-------------------------- -----------------LIQQHIF--------YQTLAAP----SPIIKFPGDS------- ------------------------------PPKTDKELAVQYLNTFYGCPKDNCNL---- ----FVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWEKNLVTYRILGYTPDLDPETVDDAFGRAFKVWSDVTPLKFSRINDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLFTMGGNGEG QPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIQGIQELYGGSTDV---------------- -----------------GPGPG----PGP-SPTLGPVTP-------------EICKNDII FDGVAQIR-GETFFFKDRFMWRTVNPRNK-PTGPLLVATFWPDLPDKIDAVYEAPQEEKT IFFSGNEYWVYSASNLERGYPKKLTN--LGLPPDVQRVNAAFNWGRNKKT-------YIF AGEKFWKYNEEKK-KMEPGF-PKFI---ADSW-NGIPDNLDAVLSPSDS---GYSYFFKE RYYLKMEDTSVKIIQI-----GNIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_006273079.1 PREDICTED: 72 kDa type IV collagenase [Alligator mississippiensis] -MKTHV----------------IFTPFGFIFKVL-------------------------- -----------------LIQQHIF--------YQTLAAP----SPIIKFPGDS------- ------------------------------PPKTDKELAVQYLNTFYGCPKDNCNL---- ----FVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWEKNLVTYRILGYTPDLDPETVDDAFGRAFKVWSDVTPLKFSRINDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLFTMGGNGEG QPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSEDPGALMAPIYT-YTKNFRLSQDDIQGIQELYGGSTDV---------------- -----------------GPGPG----PGP-SPTLGPVTP-------------EICKNDII FDGVAQIR-GETFFFKDRFMWRTVNPRNK-PTGPLLVATFWPDLPDKIDAVYEAPQEEKT IFFSGNEYWVYSASNLERGYPKKLTN--LGLPPDVQRVNAAFNWGRNKKT-------YIF AGEKFWKYNEEKK-KMEPGF-PKFI---ADSW-NGIPDNLDAVLSPSDS---GYSYFFKE RYYLKMEDTSVKIIQI-----GNIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_015808328.1 PREDICTED: 72 kDa type IV collagenase [Nothobranchius furzeri] -MGFPT----------------IVNCRRLVLKVC-------------------------- -----------------LLQLIAF--------LTANARP----SPIIRFPGDD------- ------------------------------SPTTDKEVALHYLNKFYGCPQDRCNL---- ----MVLKDTLKKMQKFFALQETGEIDDKTVEVMKKPRCGVPDV------------ANYN FFHRKPKWQKKDITYRILGYSLDLDEEVINDAFFRAFKVWSDVTPLTFTRIMDGEADIMV NFGRNEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDEQWTLGEGQVVKAKFGNA DGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDSKYGFCPHELLFTLGGNGDG APCKFPFTFQGEKYDSCTTAGRDDGYRWCATTEDYDRDKSYGFCPETAMSTVGGNADGSP CAFPFTFLGDSYDSCTSSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSQDPGALMAPIYT-FTKDFRLSHDDVQGIQELYGVPTDK---------------- --------------------------PVS--PTQGPVTPM------------DICREPVI FDAVAQIR-GETFFFKDRFLFRSVNFRSK-PNGPMLVATYWPDLPAKIDAAYENPVDEKT VFFAGNEMWIYKADELERGYPKRLSS--LGLPSDLQQIDAAFNFRKNRKT-------YLF SGDQFWRYDEDRA-TMDPGF-PKPI---AESW-NGVPDGIDAAFSLNGI---DYSYFFKG NHYFKLEDSSLKIIKL-----GEITKDWLGC----------------------------- ---------------------------------------------------------- >XP_020756186.1 72 kDa type IV collagenase [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------------MI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRTDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPSDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_030269668.1 72 kDa type IV collagenase [Sparus aurata] -MGSPT----------------IFSCRRIVLKVF-------------------------- -----------------LLQFIAF--------QATYAAP----SPIIRFPGDD------- -----------------------------TTPKTDKEVALHYLNKFYGCPQDRCNL---- ----MVLKDTLKKMQKFFSLQETGEIDAKTVDIMKKPRCGVPDV------------ANYN FFHRKPMWQKKDVTYRILGYTPDLDEEVINDAFFRAFKVWSDVTPLSFTRLMDGEADIMI NFGRNEHGDGYPFDGKDGLLAHAFAPGP---GIGGDSHFDDDEQWTLGDGQVVKVKFGNA DGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDGKYGFCPHELLFTLGGNAEG APCKFPFNFQGEKYDSCTTSGRDDGYRWCATTEDYDRDKSFGFCPETAMSTVGGNAEGSP CVFPFTFLGDTYESCTTSGRSDGKMWCAASKSYDDDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSQDPGALMAPIYT-YTKDFRLSQDDIKGIQELYGVSGDR---------------- --------------------------PSS--PTQGPVTPM------------DICKEPVI FDAVAQIR-GETFFFKDRFLFRSVNFRSK-PNGPMLVATYWPDLPSKIDAAYENPVDEKT VFFAGNEMWVYKADELEKGYPKRLSS--LELPTDLQKIDAVFNFRKNRKT-------YLF SDDKFWRYDEDSK-RMDPGF-PKLI---ADSW-NGIPDGIDAAFSLNNI---DYSYFFKG DHYFKLEDSSLKIVKL-----GEITKDWLGC----------------------------- ---------------------------------------------------------- >XP_040184680.1 72 kDa type IV collagenase [Rana temporaria] -MKCIQ----------------AIHLCAFYFQFF-------------------------- ---------------------DLI--------DQNTAAP----SPIIKFPGDT------- ------------------------------SPKTDKELVTQYLLKYYGCPKDGC-I---- ----MVLKDTLKKMQKFFHISETGEIDQKTIDTMKKPRCGNPDV------------SNYQ FFPRKPKWEKNHITYRILGYTTDLDSETVDDAFARAFQVWSDVTPLKFNRLKDGDADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGS---GIGGDSHFDDDELWTLGEGQVVKVKYGNA DGEFCKFPFKFNDKEYNSCTDAGRNDGFIWCSTTYDFDKDQKYGFCPHELLFTLAGNADG KPCKFPFKFQGNTYDSCTTEGRTDGYRWCATTEDYDKDTTYGFCPETTLSTVGGNSDGSP CVFPFTFLGNNYNSCTSTGRSDGKLWCATTSNYDNDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSDDPGALMAPIYT-YTKNFRLSQDDISGIQDLYGRGEGK---------------- -----------------EPRPG----PDP-YPTEGPVTP-------------DLCTSDIV FDGISQIR-GEIFFFKDRFIWRSVNRREK-PSGPLLVATFWSELPEKIDAVYEDPEEEKT VFFAGDEYWIYSTSALERGYPKKLTN--LGLPPDLKRVDAAFNWGRNKKT-------YLF AGDKFWRYNEAKK-KMDPGF-PKLI---ADSW-NGVHDNLDAVVDVRGS---GYSYFFKD QYYHEMEDRILKIVKV-----GNIKNDWLSC----------------------------- ---------------------------------------------------------- >KAB0351673.1 hypothetical protein FD754_016530 [Muntiacus muntjak] MTEARV----------------SRGALAAPLRAL-------------------------- -----------------CVLGCLL--------GRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPRDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVVDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >XP_043290763.1 72 kDa type IV collagenase [Cervus canadensis] MTEARV----------------SRRALAAPLRAL-------------------------- -----------------CVLGCLL--------GRAAAAP----SPIIKFPGDV------- ------------------------------APKTDKELAVQYLNTFYGCPKESCNL---- ----FVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPRDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVLDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >OWK15608.1 MMP2 [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MQKFFGLPQTGELDQSTIETMRKPRCGNPDV------------ANYN FFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGP---GVGGDSHFDDDELWTLGEGQVVRVKYGNA DGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADG QPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAP CVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA MGLEHSQDPGALMAPIYT-YTKNFRLSHDDIQGIQELYGASP------------------ -----------------DIDTG----TGP-TPTLGPVTP-------------ELCKQDIV FDGISQIR-GEIFFFKDRFIWRTVTPRDK-PTGPLLVATFWPELPEKIDAVYEDPQEEKA VFFAGNEYWVYSASTLERGYPKPLTS--LGLPRDVQKVDAAFNWSKNKKT-------YIF AGDKFWRYNEVKK-KMDPGF-PKLI---ADAW-NAIPDNLDAVLDLQGG---GHSYFFKG AYYLKLENQSLKSVKF-----GSIKSDWLGC----------------------------- ---------------------------------------------------------- >NP_001080697.1 72 kDa type IV collagenase [Xenopus laevis] -MRTIK----------------IINVLVLIFNSF-------------------------- ---------------------SIF--------YYVSPAP----SPIIKFPGDK------- ------------------------------SPKTDVELAAQYLNQFYGCPKEKCHL---- ----MVLKDALKKMQSFFGLPETGEFDQNTIETMKKPRCGNPDV------------ANYN FFPRKPKWDKNHLTYRILGYTTDLDSETVDDAFARAFKVWSDVTPLEFNRIHDGEADIMI NFGRWEHGDGYPFDGKDGLLAHAFAPGS---GVGGDSHFDDDELWTLGEGQVVKVKYGNA DGEFCNFPFLFNDKEYNSCTDSGRSDGFLWCSTTYDFDKDGKYGFCPHELLFTLTGNAEG KPCKFPFKFQGNTYNSCTTEGRTDGYRWCATTEDYDKDKMYGFCPETALSTVGGNAEGSP CVFPFTFLGNKYDSCTSSGRSDGKLWCASSSNYDDDRKWGFCPDQGYSLFLVAAHEFGHA LGLEHSQDPGALMAPIYT-YIKNFRLSQDDITGIQELYGQGS------------------ -----------------KEKPG----PGP-IPTMGPVTP-------------DLCSKDVV LDGMSQIR-GETFFFKDRFIWRTPNIRNK-PSGPLLIATFWPELPDKIDAVYEEPQEEKT VFFAGNEYWVYSSSTLERGYPKKLTS--LGLPPDVDRVDAAFNWSKNKKT-------YFF AGDKFWRYNEVKK-KMDTGF-PKLI---ADAW-NGVPDNLDAVLDQTGS---GYSYFFKD WYYFQVEGKSVKIVKV-----GNVKNDWLRC----------------------------- ---------------------------------------------------------- >XP_039256683.1 72 kDa type IV collagenase-like [Styela clava] -MYKYSRT-------------VITGLLCFALLVCYCNARPRNRHGGAPGFRAPKFMRSTS YGRKQENKFRLGVDNTGLIQGWTIKSPYQQSRLRSEAEPIQYISPRAQLNGNFGKSPAAP QRLGRRQYIPKHFEAPEAGLESAPHALKIMTESQKNAIAQEFFLKYKYAKENALN----- -----DKGDMIRTVQRNYGLNITGELNDETVVAMMRPRCGVPDAP-----------AEYN LFPNREHWTHKDITYKIEGYTPDMSQCQIRNAFKRAFRVWEEVTDLNFEKVDRDDADIII YFGYEEHGDGYPFDGPNGLLAHAFTPGTT--AISGDSHFDEGEFWTLGKGRVFDTYNGNS GGDPCVFPFYFEGASYSACTSAGRSDGLEWCATTADYDADEKWAFCPHELLFTYAGNGDN DPCVFPFVFLGKSYDECTPEGRSDGYLWCATTSNYDTDSRWGFCPSRAHGTDGGNSGGAA CTFPFKFEGYTYVDCTTVGRTDYKLWCATTDDYDKDGMWGFCNGEGYSLFLVATHEFGHA IGLDHSNVADALMYPMYS-YHADFILPDDDKRGVRDLYGPRRRYLPPLQLETCGGDLTKS EPTATRPPRTSTPTVTPRTTPRG---RTS-TPTQSTTTHSGDRCDGVVP-PTDMCQRKV- -DAVMLYQ-NEFFVFQGPFVWRVSGRGKNQVQTPERISNHWPTLKCGIDGVYQNPIDLKL MFFKGSQYFLFDGENILPGYPREVTE--LGLPARTVVDDVVFMKGRNPKTRRTENRLYYY VREKVYRADPKTG-ILMEGFKPSTLGVKGTAW-EGIPPNIDAVFSDAQNR--RYTIFVKG MKIFRYMNVRGQLDYS-----RGFKK-FFTCPIKVEE----------------------- ---------------------------------------------FIPLPLRE----- >XP_030848086.1 matrix metalloproteinase-24 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------MDEETRRLMSYPRCGMPDVIPNGD---PGQTRFRR YSDSGDKWDHQEITYRILNFTPDLTEAEVVDSFERAFKVWSDVTPLTFRRVFDVPGDIHI QFSEYDHGDGVAFDGLGGTLAHAYFPGG---SIGGDAHFDDSEIFSV------------- ------------------------------------------------------------ ------------------------------------------------------------ ------FL---------------------------------SDDDKTDLFMVAAHEFGHS LGLGHSSDIHALMAPFYVGYDPGFSLGYDDLHGIQSIYGINSSPRP-------------- ---------------GDRFIPLR---PQP-SPPDPEV---------------ERCSKSF- -NAVAFIR-NELFLFKGKNFWRMREQGKPLEGYPVEMGQFWHGLPPKVDASYERH-DGKI VFLKGSHYWVYEGVDMDPDYPRPLRE--LGLPADI---DGALPWGQTGKT-------YFF KGDVYYRYDEFDH-RMDKGY-PKLI---KENW-LGVPINIDAVFRHYDGYS-WNTYFIRH RRYWQFDESRGQVDL---GFPRNFGVDWMGCKEEDAKVDQPEGPGQLRAEVTMISSMTT- --------------------------ENSSPLTLSHSSLCLCLSISFALLLNR---S- >XP_038075032.1 collagenase 3-like [Patiria miniata] -MDATHVPNQTQRTWNIQNRRAMNAAWTCVVRLS-------------------------- -----------------LGLVLLLGP------YITQAAPT---STLLPGEGDAG-----P ENL---------------------------VTPGQLRTGFNYLTKYGFLPKPNPVA--GS LRSQAEFYDGIRAFQTFYGLPVTGALDGRTEALMAMPRCGLPDIMRDDD-----GSRKRR YVHTGATWDHQDLTYRMKNYSPDLTRSEIDEAIAGALKIWSDVIPLNFEKREMGPADIDI SFARGLHHDDYPFDGPGGTLAHAFFPGD---DLGGDAHFDDDEQFTV------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KSYEGTNLLIVAAHEFGHS LGFGHSSDLTALMAPFYQGYKPNYVLPYDDHVGAQHLYGARPGSVP-------------- ---------------SRGESPGG---EAP-GPPADPTSPPD---------QNPTCGGSY- -NAIAKIR-GELMLFKGKTFWRMLEKGHPLEGYPIDTSRFWDQLPVKVDAAYERI-DDKI LFFKGASYWEYTGTDRDPSFPRPIRE--LGLPDDI---DAALPWGETGKT-------YFF RGDQYWRYDEMER-QVDTGY-PKEV---KEKWDADVPSNMDTAFRFVDENGLWYTYFVRN KKYWRFDESRGKVDK---GFPRSFDVDWMGCPEPANNLVSTD-ETDIVVEPPKTEKMTG- --------------------------SGANPTR----GFCYKAHIFLLVLLTWMLMG- >XP_031568071.1 stromelysin-2-like isoform X2 [Actinia tenebrosa] ------------------------------------------------------------ -----------------------------------MSGP--------------------- ------------------------------------------------------------ ---------------------------------QTRPREG----------------KDAT YFMDQ-NGKKKDLTYKILNYSPDLSRKEIDDTIRDAFNVWAAVTPLTFKKVNSGKADIDI KFATYEHGDGYPFDGRGQTLAHAFYPQDNSEDIYGDAHFDDDEPFTL------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------KGKRGIDLFWVAVHEFGHS LGLDHSNHLDAIMYPFYGGYKADFKLHSDDVNGIQAIYGKPTSPSQS------------- ---------------TLAPTPTGRVTPTPHTRTDAPGVP-------------DKCSSPV- -DAFVTTEAGLTYAFKGEYFWPIAESGSW--TSALKIADFWPLVEDNVDAAFLRRSDKVN FIFKGDKFWMLKDRSALKSKPLPITDPELNLPADLANMDAAFQWGRNNKV-------YFF KGDKYWRYDPDRK-EIDIGY-PKLI---TDGWRXNIPYNLDAALQWENG----KTYFFKG LEYFAIDDYTLEIPKVDPPYPRKISTYWMGCSPE----------GVIGGKISPVESSAF- --------------------------TFLPXLVATVSTLILAKLL------------- >KAG6797835.1 Matrix metalloproteinase-14 [Apis mellifera caucasica] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------MTLPRCGVKDKVGPGF------GRSKR YALQGSRWRVKKLSYKISKYPRNLPQHKVDAELNKAFKVWSEYTDLVFVQKKSGQVHIEI RFEKGEHGDGDPFDGPGGTLAHAYFP-----VYGGDAHFDDAEQWTI------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------DSFRGTNLFQVAAHEFGHS LGLSHSDVKSALMAPFYRGYEPYFRLDEDDIQGIQALYGTKTSNN--------------- -----------------GGVPSG---PKP-TTTASPSEE-----------DSELCTNSKV DTMFNSAE-GHMYVFKGDRYWRLTSDGVA-IGYPKLISHSWKGLPGNIDAAFTYK-NGKT YFFKGSKYWRYVGKKMDGDYPKEISEGFTGIPDNI---DTVTVWTGNGKL-------YFY KGSKFWRFDPSQKPPVKNTY-PKLI----SNW-EGLPDNLDASIVYR-G----YTYFFKG DAYYRFNDRTFSVDIADPAFPRSTAYWWFGCRSANKGTLGN------GSMNRWYNSQCNG NECLWFPENAINTFLNGGDFFIP---DSVDGDNNDVGDIILDAGIKASFESDQILTSP >NP_001189004.1 matrix metalloproteinase 1, isoform J [Drosophila melanogaster] ----------------------MTNCQSSVFIVV-------------------------- -----------------GTLFSIM--------AAAQSAPV-------------------- ------------------------------STTTQAEI---YLSQFGYLPASARNPASSG LHDQRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRVGTGD------SRSKR YALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEI KFVESEHGDGDAFDGQGGTLAHAFFP-----VFGGDAHFDDAELWTI------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------GSPRGTNLFQVAAHEFGHS LGLSHSDQSSALMAPFYRGFEPVFKLDEDDKAAIQSLYGRKTNQL--------------- -------------------RPTN---VYP-ATTQRPYSPPK------VPLDDSICKDSKV DTLFNSAQ-GETYAFKGDKYYKLTTDSVE-EGYPQLISKGWPGLPGNIDAAFTYK-NGKT YFFKGTQYWRYQGRQMDGVYPKEISEGFTGIPDHL---DAAMVWGGNGKI-------YFF KGSKFWRFDPAKRPPVKASY-PKPI----SNW-EGVPNNLDAALKYTNG----YTYFFKG DKYYRFHDARFAVDSATPPFPRPTAHWWFGCKNTPSST---------GFKRRGYKNKNN- ---------------------------------------------------------- >CAE1318974.1 MMP14 [Sepia pharaonis] -MKQWR----------------LNRIRSV------------------------------- -----------------HRNYDLLNS------SVKMNEP--------------------- ------------------------------------------------------------ --------EALSDFLRWVERTRHSGPNELFSARLGRTNCSLPAWVERTVLCLP-GSNELF SARLGSKWAKRDLTYKIQQVTPRLPRLKVEREIARAFKVWSEVTSLTFTQKDMDPVDIEV LFARNHHGDRHPFDGSGGTLAHAFFP-----QFGGDAHFDDSESWSV------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------ASRQGVNLFQVAAHEIGHS LGLAHSDVRNALMAPFYRGYIPNFKLSRDDVAAVQELYGGRTDTR--------------- -----------------RFDPP----PNP-LPTQGRVSRP------------PICNDASI -DAITRLRDGTTHVFKGEEYYRLSRTGID-NGYPRKIHWDWRGVQGPIDAAVTWD-DSFT FIFKDDKYWKFDGMKPVSGYPRKIREGFKGLPDKI---DAAFVWSGNGKT-------YFI KGDRYWRW--AKY-GIDFGY-PKQL----NVW-VNLPPRVTAAFKWQNG----RTYFFNG DTYYRFNDKNFRVDD---DYPRKVSYWWLGCADETQNQQVHDVHSVITTRPRYPDKPRTV --------HVSPTQDKDKDWKVIRKGNDNGGLRMQATRLMLAGSLFVAFLRHQ-----
BMGE Cleaned alignment of selected proteins >sp|P08253|MMP2_HUMAN 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 PE=1 SV=2 ARGALTGPLRALCLLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-2|MMP2_HUMAN Isoform 2 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 ----------------------------------------------------------------MQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >sp|P08253-3|MMP2_HUMAN Isoform 3 of 72 kDa type IV collagenase OS=Homo sapiens OX=9606 GN=MMP2 --------------------------------------MQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >tr|Q6DG10|Q6DG10_DANRE 72 kDa type IV collagenase OS=Danio rerio OX=7955 GN=mmp2 PE=2 SV=1 FFSCRHIVLKVFLVQFLASSPIIKFPGDDTAHTDKEVALHYLNKFYGCPKDRCNLMVLKDTLKKMQKFFALPETGEIDQKTVEIMKKPRCGVPDVANYNFFHRKPKWGQKNVTYRILGHTPDLDEDTIDDAFYRAFKVWSDVTPLKFTRIMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKVKYGNAEGEFCKFPFLFMGKEYNSCTSQGRDDGFLWCSTTYNFDDDGKYGFCPHELLFTLGGNADGAPCKFPFTFQGDKYDSCTTSGRDDGYRWCATTEDYDKDKTYGFCPETAMSTSGGNSDGAPCVFPFKFLGDSYDSCTTSGRNDGKMWCAVTKSFDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGALMAPIYTFTKTLRLSDDDVKGIQELYGEPTDK------THTPPVTPDVCNENIIFDAVAQIRGEIFFFKDRFLFRTADVRKKPTGPMLVATFWSELPEKIDAAYENPLEERTVFFAGDEMWVYSASTLEREYPKKISSMGLPSDLHGIDAAYSFHKTKKTYIFAGNKFWRYNEAKKKMDPGFTAVPDDLDGALSLNGDGHSYFFKDSHYLKMDDSTLKIIKVGEVKKDWLRC >NP_032636.1 72 kDa type IV collagenase preproprotein [Mus musculus] AWGALAGPLRVLCVLCCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRNDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIKGIQELYGPSPDADTDTGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_112316.2 72 kDa type IV collagenase precursor [Rattus norvegicus] VWGVLVGPLRVLCVLCCLLSPIIKFPGDVSPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARALKVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYSSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNGDGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKVWCATTTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSNDDIKGIQELYGPSPDADTDTGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQQVDAAFNWSKNKKTYIFSGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_777170.1 72 kDa type IV collagenase precursor [Bos taurus] SRGALAALLRALCALGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_989751.1 72 kDa type IV collagenase preproprotein [Gallus gallus] V---FGFFFKVLLIQVYLFSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFKVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTKDFDADGKYGFCPHESLFTMGGNGDGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFIFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIKGIQELYEVSPDVGPGPGRPTLGPVTPELCKHDIVFDGVAQIRGEIFFFKDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQDEKAVFFAGNEYWVYTASNLDRGYPKKLTSLGLPPDVQRIDAAFNWGRNKKTYIFSGDRYWKYNEEKKKMELATNGVPDNLDAVLGLTDSGYTYFFKDQYYLQMEDKSLKIVKIGKISSDWLGC >NP_999357.2 72 kDa type IV collagenase precursor [Sus scrofa] ARGALAGPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKTQITYRIIGYTPDLDPETVDDAFARAFRVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFSFNGKEYNSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYNSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSHDDVKGIQELYGASP--DIDTGTPTLGPVTPEICKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_038316879.1 72 kDa type IV collagenase [Canis lupus familiaris] ----------------------------------------------------------------MQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGREYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKVWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DAGTGTPTLGPVTPEICKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRNKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGSGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_001159652.1 72 kDa type IV collagenase precursor [Ovis aries] SRGALAAPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_016785345.1 72 kDa type IV collagenase isoform X1 [Pan troglodytes] ARGALTGPLRALCLLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGSGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_001075678.1 72 kDa type IV collagenase precursor [Oryctolagus cuniculus] ARGALAGFLRALCVLGCLLSPVIKFPGDVAPKTDKELAVQYLNTFYGCPKDSCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSNVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYSSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTIGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATSTNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDAGTDAGTPTLGPVTPEICTQDIVFDGIAQIRGEIFFFKDRFIWRTVTPGDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDHLDAVVDLQGSGHSYFFKGTYYLKLENQSLKSVKVGSIKTDWLGC >NP_001290134.1 72 kDa type IV collagenase precursor [Meleagris gallopavo] V---FGFVFKVLLIQVYLFSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFKVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRNDGFLWCSTTQDFDADGKYGFCPM-SLFTMGGNGDGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFIFLGNKYDSCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIKGIQELYEVSPDVGPGPGRPTLGPVTPELCKHDIVFDGVAQIRGEIFFFKDRFMWRTVNPRGKPTGPLLVATFWPDLPEKIDAVYESPQDEKAVFFAGNEYWVYTASNLDRGYPKKLTSLGLPPDVQRVDAVFNWGRNKKTYIFSGDRYWKYNEEKKKMELASNGVPDNLDAVLGLTDSGYTYFFKDQYYLQMEDKSLKIVKMAR-------- >NP_001098349.1 72 kDa type IV collagenase precursor [Oryzias latipes] VRSCRGIVLKVFVLLFIVFSPIIRFPGDDTPKTDKEVALDYLNKFYGCPQDSCNLMVLKDTLKTMQKFFTLPETGEIDAQTVAIMKKPRCGVPDVANYNFFHNKPKWQKKDITYRILGYSPDLDEEVINDAFYRAFKVWSDVTPLSFTRIMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGGGIGGDSHFDDDEQWTLGEGQVVKAKFGNADGEFCKFPFLFMGTEYKSCTAQGRDDGFLWCSTTYNFDEDGKYGFCPHELLFTLGGNGDGAPCKFPFTFQGKQYDSCTTEGRDDGYRWCATTEDYDRDTSYGFCPETAMSTVGGNGEGSPCVFPFTFLGDTYESCTTSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGALMAPVYTFTKDFRLPQDDIQGIQELYGVPTDK------PTQGPVTPDICKESIVFDAVAQIRGETFFFKDRFLFRSVNFRSKPKGPLLVATYWPDLPAKIDAAYENPAEEKTVFFAGNQFWVYRADELQSGYPRRLSNLDLPDDVQRIDAAFNFRRNRKTYLFSGDKFWRYDEDRKTMDPGFNGIPDDLDSAFSLNGIDYSYFFKGNHYFKLEDNTLKIVKLGEIKTDWLGC >XP_024088998.1 72 kDa type IV collagenase [Pongo abelii] SRGALTGTLRALCLLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGSGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_008962127.2 72 kDa type IV collagenase [Pan paniscus] ARGALTGPLRALCLLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGSGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_003998091.2 72 kDa type IV collagenase [Felis catus] ARGALAGPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGSKHESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIKGIQELYGASP--DIDTGTPTLGPVTPEICKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRSKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNRKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_004057705.3 72 kDa type IV collagenase isoform X1 [Gorilla gorilla gorilla] ARGALTGPLRALCLLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASP--DIDLGTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGSGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_005504753.1 72 kDa type IV collagenase [Columba livia] V---CGFVFKVLLIQVYLLSPIIKFPGDSTPKTDKELAVQYLNKYYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNHITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFNRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFWFNGKEYNSCTDAGRSDGFLWCSTTKDFDADGKYGFCPHESLFTMGGNGEGQPCKFPFKFQGQSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFIFLGNKYESCTSAGRNDGKLWCASTSSYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIKGIQELYEVSPDVGPGPGRPTLGPVTPELCKHDIVFDGVAQIRGETFFFKDRFMWRTVNPRAKPTGPLLVATFWPDLPEKIDAVYEAPQDEKAVFFSGNEYWVYSASNLERGYPKKLTALGLPPDVQRVDAAFNWGRNKRTYIFAGDRYWKYNEEKKKMEIASNGVPDNLDAVLGLGDSGYTYFFKDQYYLQMEDKSLKIVKIGKINSDWLGC >XP_005692042.2 PREDICTED: 72 kDa type IV collagenase [Capra hircus] SRGALAAPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_006019137.1 72 kDa type IV collagenase [Alligator sinensis] IFTPFGFIFKVLLIQQHIFSPIIKFPGDSPPKTDKELAVQYLNTFYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNLVTYRILGYTPDLDPETVDDAFGRAFKVWSDVTPLKFSRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLFTMGGNGEGQPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIQGIQELYGGSTDVGPGPGSPTLGPVTPEICKNDIIFDGVAQIRGETFFFKDRFMWRTVNPRNKPTGPLLVATFWPDLPDKIDAVYEAPQEEKTIFFSGNEYWVYSASNLERGYPKKLTNLGLPPDVQRVNAAFNWGRNKKTYIFAGEKFWKYNEEKKKMEPGFNGIPDNLDAVLSPSDSGYSYFFKERYYLKMEDTSVKIIQIGNIKSDWLGC >XP_006273079.1 PREDICTED: 72 kDa type IV collagenase [Alligator mississippiensis] IFTPFGFIFKVLLIQQHIFSPIIKFPGDSPPKTDKELAVQYLNTFYGCPKDNCNLFVLKDTLKKMQKFFGLPETGDLDQNTIETMKKPRCGNPDVANYNFFPRKPKWEKNLVTYRILGYTPDLDPETVDDAFGRAFKVWSDVTPLKFSRINDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNDKEYNSCTNEGRSDGFLWCSTTSNFDADGKYGFCPHESLFTMGGNGEGQPCKFPFKFQGVSYDQCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRNDGKMWCASTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSEDPGALMAPIYTYTKNFRLSQDDIQGIQELYGGSTDVGPGPGSPTLGPVTPEICKNDIIFDGVAQIRGETFFFKDRFMWRTVNPRNKPTGPLLVATFWPDLPDKIDAVYEAPQEEKTIFFSGNEYWVYSASNLERGYPKKLTNLGLPPDVQRVNAAFNWGRNKKTYIFAGEKFWKYNEEKKKMEPGFNGIPDNLDAVLSPSDSGYSYFFKERYYLKMEDTSVKIIQIGNIKSDWLGC >XP_015808328.1 PREDICTED: 72 kDa type IV collagenase [Nothobranchius furzeri] IVNCRRLVLKVCLLQLIAFSPIIRFPGDDSPTTDKEVALHYLNKFYGCPQDRCNLMVLKDTLKKMQKFFALQETGEIDDKTVEVMKKPRCGVPDVANYNFFHRKPKWQKKDITYRILGYSLDLDEEVINDAFFRAFKVWSDVTPLTFTRIMDGEADIMVNFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGEGQVVKAKFGNADGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDSKYGFCPHELLFTLGGNGDGAPCKFPFTFQGEKYDSCTTAGRDDGYRWCATTEDYDRDKSYGFCPETAMSTVGGNADGSPCAFPFTFLGDSYDSCTSSGRSDGKMWCATTKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGALMAPIYTFTKDFRLSHDDVQGIQELYGVPTDK------PTQGPVTPDICREPVIFDAVAQIRGETFFFKDRFLFRSVNFRSKPNGPMLVATYWPDLPAKIDAAYENPVDEKTVFFAGNEMWIYKADELERGYPKRLSSLGLPSDLQQIDAAFNFRKNRKTYLFSGDQFWRYDEDRATMDPGFNGVPDGIDAAFSLNGIDYSYFFKGNHYFKLEDSSLKIIKLGEITKDWLGC >XP_020756186.1 72 kDa type IV collagenase [Odocoileus virginianus texanus] -------------------------------------------------------------------------------------------------------------------------------------------------------------MINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRTDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPSDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_030269668.1 72 kDa type IV collagenase [Sparus aurata] IFSCRRIVLKVFLLQFIAFSPIIRFPGDDTPKTDKEVALHYLNKFYGCPQDRCNLMVLKDTLKKMQKFFSLQETGEIDAKTVDIMKKPRCGVPDVANYNFFHRKPMWQKKDVTYRILGYTPDLDEEVINDAFFRAFKVWSDVTPLSFTRLMDGEADIMINFGRNEHGDGYPFDGKDGLLAHAFAPGPGIGGDSHFDDDEQWTLGDGQVVKVKFGNADGEFCKFPFLFMGTEYNSCTSQGRDDGFLWCSTTYNFDEDGKYGFCPHELLFTLGGNAEGAPCKFPFNFQGEKYDSCTTSGRDDGYRWCATTEDYDRDKSFGFCPETAMSTVGGNAEGSPCVFPFTFLGDTYESCTTSGRSDGKMWCAASKSYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGALMAPIYTYTKDFRLSQDDIKGIQELYGVSGDR------PTQGPVTPDICKEPVIFDAVAQIRGETFFFKDRFLFRSVNFRSKPNGPMLVATYWPDLPSKIDAAYENPVDEKTVFFAGNEMWVYKADELEKGYPKRLSSLELPTDLQKIDAVFNFRKNRKTYLFSDDKFWRYDEDSKRMDPGFNGIPDGIDAAFSLNNIDYSYFFKGDHYFKLEDSSLKIVKLGEITKDWLGC >XP_040184680.1 72 kDa type IV collagenase [Rana temporaria] AIHLCAFYFQFF----DLISPIIKFPGDTSPKTDKELVTQYLLKYYGCPKDGC-IMVLKDTLKKMQKFFHISETGEIDQKTIDTMKKPRCGNPDVSNYQFFPRKPKWEKNHITYRILGYTTDLDSETVDDAFARAFQVWSDVTPLKFNRLKDGDADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGSGIGGDSHFDDDELWTLGEGQVVKVKYGNADGEFCKFPFKFNDKEYNSCTDAGRNDGFIWCSTTYDFDKDQKYGFCPHELLFTLAGNADGKPCKFPFKFQGNTYDSCTTEGRTDGYRWCATTEDYDKDTTYGFCPETTLSTVGGNSDGSPCVFPFTFLGNNYNSCTSTGRSDGKLWCATTSNYDNDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSDDPGALMAPIYTYTKNFRLSQDDISGIQDLYGRGEGKEPRPGYPTEGPVTPDLCTSDIVFDGISQIRGEIFFFKDRFIWRSVNRREKPSGPLLVATFWSELPEKIDAVYEDPEEEKTVFFAGDEYWIYSTSALERGYPKKLTNLGLPPDLKRVDAAFNWGRNKKTYLFAGDKFWRYNEAKKKMDPGFNGVHDNLDAVVDVRGSGYSYFFKDQYYHEMEDRILKIVKVGNIKNDWLSC >KAB0351673.1 hypothetical protein FD754_016530 [Muntiacus muntjak] SRGALAAPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >XP_043290763.1 72 kDa type IV collagenase [Cervus canadensis] SRRALAAPLRALCVLGCLLSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVLDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >OWK15608.1 MMP2 [Cervus elaphus hippelaphus] ----------------------------------------------------------------MQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDGCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASP--DIDTGTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPRDVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFNAIPDNLDAVLDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC >NP_001080697.1 72 kDa type IV collagenase [Xenopus laevis] IINVLVLIFNSF----SIFSPIIKFPGDKSPKTDVELAAQYLNQFYGCPKEKCHLMVLKDALKKMQSFFGLPETGEFDQNTIETMKKPRCGNPDVANYNFFPRKPKWDKNHLTYRILGYTTDLDSETVDDAFARAFKVWSDVTPLEFNRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGSGVGGDSHFDDDELWTLGEGQVVKVKYGNADGEFCNFPFLFNDKEYNSCTDSGRSDGFLWCSTTYDFDKDGKYGFCPHELLFTLTGNAEGKPCKFPFKFQGNTYNSCTTEGRTDGYRWCATTEDYDKDKMYGFCPETALSTVGGNAEGSPCVFPFTFLGNKYDSCTSSGRSDGKLWCASSSNYDDDRKWGFCPDQGYSLFLVAAHEFGHALGLEHSQDPGALMAPIYTYIKNFRLSQDDITGIQELYGQGS--KEKPGIPTMGPVTPDLCSKDVVLDGMSQIRGETFFFKDRFIWRTPNIRNKPSGPLLIATFWPELPDKIDAVYEEPQEEKTVFFAGNEYWVYSSSTLERGYPKKLTSLGLPPDVDRVDAAFNWSKNKKTYFFAGDKFWRYNEVKKKMDTGFNGVPDNLDAVLDQTGSGYSYFFKDWYYFQVEGKSVKIVKVGNVKNDWLRC >XP_039256683.1 72 kDa type IV collagenase-like [Styela clava] ITGLLCFALLVCLIQGWTISPRAQLNGNFTESQKNAIAQEFFLKYKYAKENALN--DKGDMIRTVQRNYGLNITGELNDETVVAMMRPRCGVPDAAEYNLFPNREHWTHKDITYKIEGYTPDMSQCQIRNAFKRAFRVWEEVTDLNFEKVDRDDADIIIYFGYEEHGDGYPFDGPNGLLAHAFTPGTAISGDSHFDEGEFWTLGKGRVFDTYNGNSGGDPCVFPFYFEGASYSACTSAGRSDGLEWCATTADYDADEKWAFCPHELLFTYAGNGDNDPCVFPFVFLGKSYDECTPEGRSDGYLWCATTSNYDTDSRWGFCPSRAHGTDGGNSGGAACTFPFKFEGYTYVDCTTVGRTDYKLWCATTDDYDKDGMWGFCNGEGYSLFLVATHEFGHAIGLDHSNVADALMYPMYSYHADFILPDDDKRGVRDLYGPRRRYRTTPRTPTQSTTTHDMCQRKV--DAVMLYQNEFFVFQGPFVWRVSGRGKNVQTPERISNHWPTLKCGIDGVYQNPIDLKLMFFKGSQYFLFDGENILPGYPREVTELGLPARTVVDDVVFMKGRNPKTYYYVREKVYRADPKTGILMEGFEGIPPNIDAVFSDAQNRYTIFVKGMKIFRYMNVRGQLDYSRGFKK-FFTC >XP_030848086.1 matrix metalloproteinase-24 [Strongylocentrotus purpuratus] ----------------------------------------------------------------------------MDEETRRLMSYPRCGMPDVRFRRYSDSGDKWDHQEITYRILNFTPDLTEAEVVDSFERAFKVWSDVTPLTFRRVFDVPGDIHIQFSEYDHGDGVAFDGLGGTLAHAYFPGGSIGGDAHFDDSEIFSV-------------------------------------------------------------------------------------------------------------------------------------------FL---------------------------------SDDDKTDLFMVAAHEFGHSLGLGHSSDIHALMAPFYVYDPGFSLGYDDLHGIQSIYGINSSPRFIPLSPPDPEV--ERCSKSF--NAVAFIRNELFLFKGKNFWRMREQGKPEGYPVEMGQFWHGLPPKVDASYERH-DGKIVFLKGSHYWVYEGVDMDPDYPRPLRELGLPADI---DGALPWGQTGKTYFFKGDVYYRYDEFDHRMDKGYLGVPINIDAVFRHYDGWNTYFIRHRRYWQFDESRGQVDL-RNFGVDWMGC >XP_038075032.1 collagenase 3-like [Patiria miniata] MNAAWTCVVRLSLGLVLLLSTLLPGEGDAVTPGQLRTGFNYLTKYGFLPKPNPVAAEFYDGIRAFQTFYGLPVTGALDGRTEALMAMPRCGLPDIRKRRYVHTGATWDHQDLTYRMKNYSPDLTRSEIDEAIAGALKIWSDVIPLNFEKREMGPADIDISFARGLHHDDYPFDGPGGTLAHAFFPGDDLGGDAHFDDDEQFTV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KSYEGTNLLIVAAHEFGHSLGFGHSSDLTALMAPFYQYKPNYVLPYDDHVGAQHLYGARPGSGESPGGPPADPTSPPTCGGSY--NAIAKIRGELMLFKGKTFWRMLEKGHPEGYPIDTSRFWDQLPVKVDAAYERI-DDKILFFKGASYWEYTGTDRDPSFPRPIRELGLPDDI---DAALPWGETGKTYFFRGDQYWRYDEMERQVDTGYADVPSNMDTAFRFVDEWYTYFVRNKKYWRFDESRGKVDK-RSFDVDWMGC >XP_031568071.1 stromelysin-2-like isoform X2 [Actinia tenebrosa] ------------------------------------------------------------------------------------QTRPREG----KDATYFMDQ-NGKKKDLTYKILNYSPDLSRKEIDDTIRDAFNVWAAVTPLTFKKVNSGKADIDIKFATYEHGDGYPFDGRGQTLAHAFYPQDDIYGDAHFDDDEPFTL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KGKRGIDLFWVAVHEFGHSLGLDHSNHLDAIMYPFYGYKADFKLHSDDVNGIQAIYGKPTSPAPTPTTRTDAPGVPDKCSSPV--DAFVTTEGLTYAFKGEYFWPIAESGSW-TSALKIADFWPLVEDNVDAAFLRRSDKVNFIFKGDKFWMLKDRSALKSKPLPITDLNLPADLANMDAAFQWGRNNKVYFFKGDKYWRYDPDRKEIDIGYXNIPYNLDAALQWENG-KTYFFKGLEYFAIDDYTLEIPKVRKISTYWMGC >KAG6797835.1 Matrix metalloproteinase-14 [Apis mellifera caucasica] ------------------------------------------------------------------------------------MTLPRCGVKDKRSKRYALQGSRWRVKKLSYKISKYPRNLPQHKVDAELNKAFKVWSEYTDLVFVQKKSGQVHIEIRFEKGEHGDGDPFDGPGGTLAHAYFP--VYGGDAHFDDAEQWTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DSFRGTNLFQVAAHEFGHSLGLSHSDVKSALMAPFYRYEPYFRLDEDDIQGIQALYGTKTSNGGVPSTTTASPSEEELCTNSKVDTMFNSAEGHMYVFKGDRYWRLTSDGVAIGYPKLISHSWKGLPGNIDAAFTYK-NGKTYFFKGSKYWRYVGKKMDGDYPKEISETGIPDNI---DTVTVWTGNGKLYFYKGSKFWRFDPSQKPVKNTYEGLPDNLDASIVYR-G-YTYFFKGDAYYRFNDRTFSVDIARSTAYWWFGC >NP_001189004.1 matrix metalloproteinase 1, isoform J [Drosophila melanogaster] MTNCQSSVFIVVGTLFSIM----------STTTQAEI---YLSQFGYLPASARNPRTWVSAIEEFQSFAGLNITGELDAETMKLMSLPRCGVRDRRSKRYALQGSRWRVKNLTYKISKYPKRLKRVDVDAEIGRAFAVWSEDTDLTFTRKTSGPVHIEIKFVESEHGDGDAFDGQGGTLAHAFFP--VFGGDAHFDDAELWTI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GSPRGTNLFQVAAHEFGHSLGLSHSDQSSALMAPFYRFEPVFKLDEDDKAAIQSLYGRKTNQ--RPTATTQRPYSPSICKDSKVDTLFNSAQGETYAFKGDKYYKLTTDSVEEGYPQLISKGWPGLPGNIDAAFTYK-NGKTYFFKGTQYWRYQGRQMDGVYPKEISETGIPDHL---DAAMVWGGNGKIYFFKGSKFWRFDPAKRPVKASYEGVPNNLDAALKYTNG-YTYFFKGDKYYRFHDARFAVDSARPTAHWWFGC >CAE1318974.1 MMP14 [Sepia pharaonis] LNRIRSV-----HRNYDLL----------------------------------------EALSDFLRWVERTRHSGPNELFSARLGRTNCSLPAWNELFSARLGSKWAKRDLTYKIQQVTPRLPRLKVEREIARAFKVWSEVTSLTFTQKDMDPVDIEVLFARNHHGDRHPFDGSGGTLAHAFFP--QFGGDAHFDDSESWSV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ASRQGVNLFQVAAHEIGHSLGLAHSDVRNALMAPFYRYIPNFKLSRDDVAAVQELYGGRTDTRFDPPLPTQGRVSRPICNDASI-DAITRLRGTTHVFKGEEYYRLSRTGIDNGYPRKIHWDWRGVQGPIDAAVTWD-DSFTFIFKDDKYWKFDGMKPVSGYPRKIREKGLPDKI---DAAFVWSGNGKTYFIKGDRYWRW--AKYGIDFGYVNLPPRVTAAFKWQNG-RTYFFNGDTYYRFNDKNFRVDD-RKVSYWWLGC
PhyML tree of selected proteins (CAE1318974_1_MMP14__Sepia_pharaonis_:0.92871136,((XP_031568071_1_stromelysin_2_like_isoform_X2__Actinia_tenebrosa_:0.95712277,(XP_039256683_1_72_kDa_type_IV_collagenase_like__Styela_clava_:1.23689122,(((((NP_001075678_1_72_kDa_type_IV_collagenase_precursor__Oryctolagus_cuniculus_:0.03178956,((XP_003998091_2_72_kDa_type_IV_collagenase__Felis_catus_:0.00532538,(XP_038316879_1_72_kDa_type_IV_collagenase__Canis_lupus_familiaris_:0.01867643,(NP_999357_2_72_kDa_type_IV_collagenase_precursor__Sus_scrofa_:0.01225699,((XP_005692042_2_PREDICTED__72_kDa_type_IV_collagenase__Capra_hircus_:0.00000001,(NP_001159652_1_72_kDa_type_IV_collagenase_precursor__Ovis_aries_:0.00000001,NP_777170_1_72_kDa_type_IV_collagenase_precursor__Bos_taurus_:0.01040441):0.00172557):0.00000001,(XP_020756186_1_72_kDa_type_IV_collagenase__Odocoileus_virginianus_texanus_:0.00383082,(KAB0351673_1_hypothetical_protein_FD754_016530__Muntiacus_muntjak_:0.00000001,(OWK15608_1_MMP2__Cervus_elaphus_hippelaphus_:0.00000001,XP_043290763_1_72_kDa_type_IV_collagenase__Cervus_canadensis_:0.00000001):0.00346529):0.00107995):0.00310385):0.0142798):0.00474832):0.00238899):0.0079295,(sp_P08253_3_MMP2_HUMAN_Isoform_3_of_72_kDa_type_IV_collagenase_OS_Homo_sapiens_OX_9606_GN_MMP2:0.00190601,(sp_P08253_2_MMP2_HUMAN_Isoform_2_of_72_kDa_type_IV_collagenase_OS_Homo_sapiens_OX_9606_GN_MMP2:0.00000001,(sp_P08253_MMP2_HUMAN_72_kDa_type_IV_collagenase_OS_Homo_sapiens_OX_9606_GN_MMP2_PE_1_SV_2:0.00000001,((XP_008962127_2_72_kDa_type_IV_collagenase__Pan_paniscus_:0.00000001,(XP_016785345_1_72_kDa_type_IV_collagenase_isoform_X1__Pan_troglodytes_:0.00000001,XP_004057705_3_72_kDa_type_IV_collagenase_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001,XP_024088998_1_72_kDa_type_IV_collagenase__Pongo_abelii_:0.00344436):0.00172394):0.00000001):0.00000001):0.0112557):0.00354156):0.01032296,(NP_032636_1_72_kDa_type_IV_collagenase_preproprotein__Mus_musculus_:0.00172625,NP_112316_2_72_kDa_type_IV_collagenase_precursor__Rattus_norvegicus_:0.01212767):0.01267688):0.1120172,((XP_006019137_1_72_kDa_type_IV_collagenase__Alligator_sinensis_:0.00000001,XP_006273079_1_PREDICTED__72_kDa_type_IV_collagenase__Alligator_mississippiensis_:0.00000001):0.06590989,(XP_005504753_1_72_kDa_type_IV_collagenase__Columba_livia_:0.01651636,(NP_001290134_1_72_kDa_type_IV_collagenase_precursor__Meleagris_gallopavo_:0.01081886,NP_989751_1_72_kDa_type_IV_collagenase_preproprotein__Gallus_gallus_:0.00562769):0.01649705):0.05477727):0.04964581):0.05657296,(XP_040184680_1_72_kDa_type_IV_collagenase__Rana_temporaria_:0.15074567,NP_001080697_1_72_kDa_type_IV_collagenase__Xenopus_laevis_:0.1134812):0.05699689):0.07795457,(tr_Q6DG10_Q6DG10_DANRE_72_kDa_type_IV_collagenase_OS_Danio_rerio_OX_7955_GN_mmp2_PE_2_SV_1:0.1349839,(NP_001098349_1_72_kDa_type_IV_collagenase_precursor__Oryzias_latipes_:0.08403289,(XP_015808328_1_PREDICTED__72_kDa_type_IV_collagenase__Nothobranchius_furzeri_:0.05136799,XP_030269668_1_72_kDa_type_IV_collagenase__Sparus_aurata_:0.05331727):0.01711656):0.08687672):0.10205389):0.48776525):0.36986792):0.18101166,(XP_038075032_1_collagenase_3_like__Patiria_miniata_:0.47443604,XP_030848086_1_matrix_metalloproteinase_24__Strongylocentrotus_purpuratus_:0.59118694):0.4151237):0.37596939,(KAG6797835_1_Matrix_metalloproteinase_14__Apis_mellifera_caucasica_:0.31644802,NP_001189004_1_matrix_metalloproteinase_1__isoform_J__Drosophila_melanogaster_:0.17326246):0.43563486);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)