PB0200

DATABASE

Click here to access PB0200 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0200	P10909	Clusterin	CLU		Homo_sapiens	Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed:21567405).

Domains

Gene Ontology

PF01093 (Clusterin)

GO:0005856 (colocalizes with) cytoskeleton GO:0071944 (colocalizes with) cell periphery GO:0001540 (enables) amyloid-beta binding GO:0005102 (enables) signaling receptor binding GO:0005515 (enables) protein binding GO:0031625 (enables) ubiquitin protein ligase binding GO:0044877 (enables) protein-containing complex binding GO:0048156 (enables) tau protein binding GO:0050750 (enables) low-density lipoprotein particle receptor binding GO:0051082 (enables) unfolded protein binding GO:0051087 (enables) chaperone binding GO:0051787 (enables) misfolded protein binding GO:0140597 (enables) protein carrier chaperone GO:0000902 (involved in) cell morphogenesis GO:0001774 (involved in) microglial cell activation GO:0001836 (involved in) release of cytochrome c from mitochondria GO:0002376 (involved in) immune system process GO:0002434 (involved in) immune complex clearance GO:0006629 (involved in) lipid metabolic process GO:0006915 (involved in) apoptotic process GO:0006956 (involved in) complement activation GO:0006958 (involved in) complement activation, classical pathway GO:0009615 (involved in) response to virus GO:0010628 (involved in) positive regulation of gene expression GO:0017038 (involved in) protein import GO:0031333 (involved in) negative regulation of protein-containing complex assembly GO:0031334 (involved in) positive regulation of protein-containing complex assembly GO:0032286 (involved in) central nervous system myelin maintenance GO:0032436 (involved in) positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032760 (involved in) positive regulation of tumor necrosis factor production GO:0042127 (involved in) regulation of cell population proliferation GO:0042981 (involved in) regulation of apoptotic process GO:0043065 (involved in) positive regulation of apoptotic process GO:0043691 (involved in) reverse cholesterol transport GO:0045087 (involved in) innate immune response GO:0045429 (involved in) positive regulation of nitric oxide biosynthetic process GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis GO:0050821 (involved in) protein stabilization GO:0051092 (involved in) positive regulation of NF-kappaB transcription factor activity GO:0051131 (involved in) chaperone-mediated protein complex assembly GO:0051788 (involved in) response to misfolded protein GO:0060548 (involved in) negative regulation of cell death GO:0061077 (involved in) chaperone-mediated protein folding GO:0061518 (involved in) microglial cell proliferation GO:0061740 (involved in) protein targeting to lysosome involved in chaperone-mediated autophagy GO:0090201 (involved in) negative regulation of release of cytochrome c from mitochondria GO:1900221 (involved in) regulation of amyloid-beta clearance GO:1901214 (involved in) regulation of neuron death GO:1901216 (involved in) positive regulation of neuron death GO:1902004 (involved in) positive regulation of amyloid-beta formation GO:1902230 (involved in) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:1902430 (involved in) negative regulation of amyloid-beta formation GO:1902847 (involved in) regulation of neuronal signal transduction GO:1902949 (involved in) positive regulation of tau-protein kinase activity GO:1902998 (involved in) positive regulation of neurofibrillary tangle assembly GO:1903573 (involved in) negative regulation of response to endoplasmic reticulum stress GO:1905892 (involved in) negative regulation of cellular response to thapsigargin GO:1905895 (involved in) negative regulation of cellular response to tunicamycin GO:1905907 (involved in) negative regulation of amyloid fibril formation GO:1905908 (involved in) positive regulation of amyloid fibril formation GO:2000060 (involved in) positive regulation of ubiquitin-dependent protein catabolic process GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005739 (located in) mitochondrion GO:0005743 (located in) mitochondrial inner membrane GO:0005783 (located in) endoplasmic reticulum GO:0005794 (located in) Golgi apparatus GO:0005829 (located in) cytosol GO:0009986 (located in) cell surface GO:0016020 (located in) membrane GO:0031093 (located in) platelet alpha granule lumen GO:0031410 (located in) cytoplasmic vesicle GO:0031966 (located in) mitochondrial membrane GO:0042583 (located in) chromaffin granule GO:0043231 (located in) intracellular membrane-bounded organelle GO:0045202 (located in) synapse GO:0048471 (located in) perinuclear region of cytoplasm GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:0072562 (located in) blood microparticle GO:0097418 (located in) neurofibrillary tangle GO:0097440 (located in) apical dendrite GO:0099020 (located in) perinuclear endoplasmic reticulum lumen GO:0032991 (part of) protein-containing complex GO:0034366 (part of) spherical high-density lipoprotein particle

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P10909|CLUS_HUMAN Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1 MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLI EKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQT CMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHF SRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNF HAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKD QCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLE QLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVP VEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-2|CLUS_HUMAN Isoform 2 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MQVCSQPQRGCVREQSAINTAPPSAHNAASPGGARGHRVPLTEACKDSRIGGMMKTLLLF VGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERK TLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARV CRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIID ELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFL EMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREI LSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNW VSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNP KFMETVAEKALQEYRKKHREE >sp|P10909-3|CLUS_HUMAN Isoform 3 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPY EPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGC LRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNT SSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPI TVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-4|CLUS_HUMAN Isoform 4 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESET KLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFW MNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPH RRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTE FIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQV AERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHT SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-5|CLUS_HUMAN Isoform 5 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNA VNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMAL WEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQ THMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSL MPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIR HNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQ WKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKL FDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-6|CLUS_HUMAN Isoform 6 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKK KEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQL EEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREP QDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDI HFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQ AKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGED QYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQ EYRKKHREE >tr|Q5SPR2|Q5SPR2_DANRE Clusterin OS=Danio rerio OX=7955 GN=clu PE=3 SV=1 MMKVLWSLLGLFLLYLSTECLLPPSKEELNQMSQVGEKYLDRQIENAISGVKEMKTVMER SEEEHKRMLSEMEKTQKEKENALKMAQEMKEKLSEEQSVCNETMEALWEECKPCLRKTCV KFYSRTCRSGSGLVGRQLEEILNRTSPISIFINGQSIETLLSEDQQQTRHFQDLEESYTE VSDGVENMFTDSMKVFDHMQMFHHPGFFPSRFQFPSMFGGHEGSTHAGRIYRSPMHDSLF HSLQSLFRPMERSMSMFGKNEERNFTSEGWKLNEKVTTDDKMTCKEIRRNSFGCVKLKDE CEKCQQIQHIDCSGKRPLEGPLKEELERALGKAEEFTQEFNNLLNIFQEQMFNTSSLLDL FNKQFGWVSSLANHTQNEDGFFQIQAVMSKGSDNAENPADTRVSVKLFDGPDMIYTVPGD IPWSDPKFSEVVAQEALDRYKQNAVITKL
Selected proteins from model organisms >sp|P10909|CLUS_HUMAN Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1 MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLI EKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQT CMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHF SRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNF HAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKD QCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLE QLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVP VEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-2|CLUS_HUMAN Isoform 2 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MQVCSQPQRGCVREQSAINTAPPSAHNAASPGGARGHRVPLTEACKDSRIGGMMKTLLLF VGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERK TLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARV CRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIID ELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFL EMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREI LSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNW VSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNP KFMETVAEKALQEYRKKHREE >sp|P10909-3|CLUS_HUMAN Isoform 3 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPY EPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGC LRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNT SSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPI TVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-4|CLUS_HUMAN Isoform 4 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESET KLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFW MNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPH RRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTE FIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQV AERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHT SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-5|CLUS_HUMAN Isoform 5 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSNQGSKYVNKEIQNA VNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMAL WEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQ THMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSL MPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIR HNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQ WKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPSGVTEVVVKL FDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-6|CLUS_HUMAN Isoform 6 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKK KEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQL EEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREP QDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDI HFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQ AKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGED QYYLRVTTVASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQ EYRKKHREE >tr|Q5SPR2|Q5SPR2_DANRE Clusterin OS=Danio rerio OX=7955 GN=clu PE=3 SV=1 MMKVLWSLLGLFLLYLSTECLLPPSKEELNQMSQVGEKYLDRQIENAISGVKEMKTVMER SEEEHKRMLSEMEKTQKEKENALKMAQEMKEKLSEEQSVCNETMEALWEECKPCLRKTCV KFYSRTCRSGSGLVGRQLEEILNRTSPISIFINGQSIETLLSEDQQQTRHFQDLEESYTE VSDGVENMFTDSMKVFDHMQMFHHPGFFPSRFQFPSMFGGHEGSTHAGRIYRSPMHDSLF HSLQSLFRPMERSMSMFGKNEERNFTSEGWKLNEKVTTDDKMTCKEIRRNSFGCVKLKDE CEKCQQIQHIDCSGKRPLEGPLKEELERALGKAEEFTQEFNNLLNIFQEQMFNTSSLLDL FNKQFGWVSSLANHTQNEDGFFQIQAVMSKGSDNAENPADTRVSVKLFDGPDMIYTVPGD IPWSDPKFSEVVAQEALDRYKQNAVITKL >XP_015803151.1 PREDICTED: clusterin [Nothobranchius furzeri] MLIIMMMMKKKGSKESLAVMALALLSSASCILPPSREDLNEISVQGERYLDKQIENAIGGVKEMKNVMQKSSEDHKKFLD ALEKTKQQKEEAIRTAEEMEAKLEKEEEVCNETMKALWEECKPCLKNTCIKYYSRTCSSGSGLVGRQLEDVLNRTSPFSI WINGERIDTLEQEGRRQSKKFRNVEEKYTEMSEGVESIFSDSMKVADHVHPPMFFFPRFLAPVMRRSRSIHTLFHDPFHN FQSLFSPMMGRNLFGSMDAMTDLDSDTPTNQDGSVNEDVIITRPFGSGKMTCREIRRNSAGCIKFRDECEKCKEIQHLDC SGKKPLEGPLKEELEEALAMAERFTQQYNVLLKRFEEQMFNTSSILDLLNKQFGWVSSLANNTQDGIFHVKVVATGPEVQ SGEKEPADTRVSVQLFDSPSMNFTISGDIPWTDPKFSEVVAQEALDRYKETSVLVK >XP_030261895.1 clusterin isoform X1 [Sparus aurata] MLMMMMMMKKKKASKILAVVALLVATVNGVLLPTKEDLYQISLQGEKYLDRQIENAVNGVKEMKTVMQKSSEDHQKLLDA LEKTKEQKEEAMRAAQEMETKLEQEEEVCNETMKTLWEECKPCLKNTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIW INGEKIDVLEQEGQRQSKEFRNLEEKYTEMADGVDSIFTDSMKVADHVHYNPPVFYLPNFLGPYARQTRSIRSLFRDPFH GFQNLFSPMSGMSRNFFSSMGSMMDMDSDTPPNEDGSVNEDVVITKPFGNGRMTCREIRRNSAGCLRFREECQKCKEIQH IDCSGKRPLEGPLKEELEEALAMAERFTQLYNNLLTRFEEQMVNTSSLLDMLNSQFGWVSSLANNTKDNIFQVQTVLCKD TEEKPAGEEKQHEETAVSVQVFDSPPMNVSVPGDIPWTDPKFSEVVAQKALDRYKETSVMVK >XP_011490335.1 clusterin isoform X2 [Oryzias latipes] MLMMMMMMRKKGSKESLAMLALLLASASSILPPSEKDLNEISQQGERYLDTQIENAITGVKKMKEVMQKSTEDHNKFLDA LQKKKQQKEEAIREAQEMEAKLVHEEEACNETMKALWEECKPCLKTTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIW VNGERIDTLEQEGQQQNKEFKNLEERYTEMADGVDSIFSDSMKVADHIHLNPPVFFFPHFLSPYARRARSIRSLFQDPFH NFQSLFSPMMGRNFFDSMMDMSSDPVPNEDGDVNEDVVVTKPFGNGRMTCREIRRNSAGCIKFRNECEKCKEIQHLDCDG KKPLEGPLKEELEEALATAERFTQQYTSLLQRMEEQLFNTSSILDMFNKQFGWVSTLANSTKDGLFRVKAVISRDSPTEE KPAETSVEVQLFDSPPMTFTVPGEIPWTDPKFSEVVAQEALDRYKEISVVVK >XP_006033945.1 clusterin [Alligator sinensis] MALLLLSLLGLLLTWEGGQAVIPTSELKQLSVAGSKYLDTEIENAINGVKQMKTLMDKTSKDHQAILDTLEETKQQKEEA MRQARQKEQLLSETRDVCNETVLALWEECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWVDGERVDSLLD EDKQQGRWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFAGGFQEALRSPFRSPRLPSTRVVRDLPSPFFRLHD PTQSFQHLFQPLFEMTQRMFEGAQRAMENDRHWFGKGWDSLPGGVSTETYNTSDARMVCREIRRNSAGCLKMKDRCEKCK EILAVDCSDPAHSQLREQFEDALRIAERFSHRYDELLEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGSGRDDGFFQ VTTVLSKTPDPRDPSLPADTQVTVQIFDSEPLVLTVPGDISWDDPKFMEVVADEALRLYKQNNVV >KYO32283.1 clusterin [Alligator mississippiensis] MQALGRGGAQLGRSPEQRAQPGSYRVCELKQLSVAGSKYLDTEIENAINGVKQMKSLMDKTSKDHQAILDTLEETKQQKE EAMRQARQKEQLLSETRDVCNETVLALWEECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWMDGERVDSL LDEDKQQSRWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFAGGFQEALRSPFRSPRLPSTRVVRDLPSPFFRL HDPTQSFQHLFQPLFEMTQRMFEGAQRAMENDRHWFGKGWDSLPGGVSTETYNTSDARMVCREIRRNSAGCLKMKDQCEK CKEILAVDCSDPAHSQLREQFEDALRIAERFSHRYDELMEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGSGRNDGF FQVTTVLSKTPDPRDPSLPADTQVTVQIFDSEPLVLTVPGDISWDDPKFMEVVADEALRLYKQNNVV >NP_001383106.1 clusterin precursor [Gallus gallus] MALPLLALLSLGLVCQGGQGLVPPSELKQLSAAGSKYIDTEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKRRKEEA VKLALEKEKQLAEKQEVCNETMLSLWEECKPCLKHTCMRVYSKICHSGSGLVGRQLEELLNRSSPFSIWVNGERIDALLD REQRQERRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFGGFREAFVPPVQRVRLVPPRRRLSRELHPFLQHP VHGFHRLFEMTQRMLDGGHGAWDHLLGGFESESRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQ LREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLGNLTQGTDGFLQVTTVFSKTPNLEDPSAPA DTQVTVQLFDSEPLSLTVPGDISWDDPRFMEIVAEQALQHFKQNNTIE >XP_010706357.1 LOW QUALITY PROTEIN: clusterin [Meleagris gallopavo] MALLLLALLSLGLVCQGGQGLMPPSELKQLSAAGSKYIDTEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKRKKEEA VKLALEKEKQLAEKQDVCNESMLSLWEECKPCLKHTCMRVYSKICHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDELLD REQRQERRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFGGFREXFVPPVQRVHLVPRRRLSRELHPFFQHPV HGFHRLFQPLFEMTQRMLDGGHGAWEHPLGGFASEPRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPV QSQLREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLKNLTQGTDGFLQVTTVFSKTPNLEDPS APADTQVTVQLFDSEPLSLTVPGDISWDDPRFMEIVAEQALQHYKQKNTIE >XP_040204262.1 clusterin [Rana temporaria] MRMVPLSLLLVAVLLNFTGALLPPESLKKISEEGRKYITEQFENAVNGVRQMKKLMDQTGEEHQKILRTLEETKKNKEDA LKQALESEQQLSETQEICNDTMLALWEECKPCLKQTCVRFYSKTCRSGSGLVGRQLEDFLNRSSPFAIWVNGERIDTLNK QDEQQHMALEDLEDGYSIVEDSVHELFQDSMKAFDHMKPLFSKPFHGFSFPQWEQFPFQKISTPVSAMRIRKERSPLFEP FFTSNFDSLFEAAQKMMEKHRQMIQQGPQFDGMNNSTDDKTVCRELRRNTAGCLRMKDKCEKCKEILAVDCSGKNTMQEK LREKFEDSVRLAEKYTTLYDDLLQRFREKMLNTTGLLEDLSHQYSWVSKLANLTDNDLKGIFQMSTAYSSSGGAPSDTTV TVKLFDSESFTFTVPGHISMEDPTFGELVAEEALKRFKKEVIEAA >NP_001080775.1 clusterin precursor [Xenopus laevis] MNMYKFPFLLVGLLVGLSAAVLPPENLNQISIEGSRYITEQVENAVNGVKKMKSIMDQTGKEHQEIMRNLEETKKNKEEA LKRALDTEQELEEKKEVCNETMLALWEECKPCLKQTCVRFYSKTCRSGSGLVGRQFEEFLNRSSPFSIFINGEKINSLTQ EGEQQHMTLDDLEGGYSLVEDSVDELFRESIKAFGQMKPFFSNSFHNGFFESQWNPFPFQRVGFPFSESRQARSPTFNPY FSGNFESLIEAAQKMMERSHHFVPRLDGLGSIRGNGNDSDDKLVCKELRRNSASCLKMQEKCEKCKEILAVDCTGKDPVQ EHLQEVFQDSLRLAEKFTRQYDDLLEQFREKMFNTTGILEQLNKQFGWLSKFANMTQSGKNGIFQVSTIYSKEGESPSDT KVTVNVFDSDPITFTLPGYISMDDPMFGELVAEEALKKFKTEVVEAA >XP_004046872.3 clusterin isoform X1 [Gorilla gorilla gorilla] MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKK KEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRID SLLENDRQQTHMLDVMQDHFSRVSSIMDKLFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNF HAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQ AQLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDVPS GVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >NP_001075518.1 clusterin precursor [Oryctolagus cuniculus] MKTLLLCVGLLLSWERGQVLGDQLVSDNELQEMSTQGSKYIDREIQNAVKGVQEIKTLIEKTNEERKTLLSVLEEAKKNK EDALNETRDSETKLKAFPEVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWINGDRIDS LLENDRQQSHVLDVMQDSFNRATGIMDELFQDRFFTHKPQDTFYHSPFSYFRRPPLHYAKSRLVRNIMPLSLYGPLNFQD MFQPFFEMIHQAQQAMDVHLHSPAYQTPNVEFITGGPDDRAVCKEIRHNSTGCLRMKDQCAKCQEILSVDCSANNPSQNQ LRQELNDSLRLAEELTKRYNELLQSYQWKMLNTSSLLDQPNEQFNWVSQLANLTQGPDQYYLRVSTVTSHTSESEAPSRV TEVVVKLFDSDPITITIPEEVSRDNPKFMETVAEKALQEYRKKKRVE >XP_003984849.1 clusterin [Felis catus] MKTLLLLVGLLLTCENGRVLGDKAVSDAELQEMSTEGSKYINKEIKNALKGVKQIKTLIEQTNEERKSLLSNLEEAKKKK EDALSDTKDSEMKLKASEGVCNDTMMALWEECKPCLKQTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWINGDRIDS LLENDRQQTHALDVMQDSFNRASRIMDELFQDRFFTREPQDTYHYSPFSSLQRRPFFFNPKSRFARNVMPFPAFQPLNFH DMFQPFFDMIHQAQQAMDINLQRIPYHFPMEFTEEDNQDRMVCKEIRHNSTGCLRMKDQCDKCQEILSVDCSASNPSQVL LRQELNNSLQMAEKFTKLYDELLRSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSEDPFYLQVTTVSSQTSDSNVPSGF TKVVVKLFDSDPISVMVPEEVSRNNPKFMETVAEKALQEYRQKNGEK >XP_003777274.1 clusterin isoform X2 [Pongo abelii] MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKK KEDALNETRESETKLKEFPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRID SLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAQEPQDTYHYLPFSLPHRRPHFFFPKSRIIRSLMPFSPYEPLNF HAMFQPFLEMIHEAQQAMDVHFHSPAFQLPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQ AQLRRELNESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANVTQGKDQYYLRVTTVASHTSDSDVPS GVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >XP_001164647.1 clusterin isoform X2 [Pan troglodytes] MMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKK KEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRID SLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNF HAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSASNPSQ AQLRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASHTSDSDIPS GVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >XP_034821769.1 clusterin isoform X2 [Pan paniscus] MEACKDSRIGGMMKTLLLFVGLLLTWESGQVLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKT LLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSP FYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSL MPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPTEFIREGDDDRTVCREIRHNSTGCLRMKDQCDKCREIL SVDCSASNPSQAQLRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTV ASHTSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >NP_001003370.1 clusterin precursor [Canis lupus familiaris] MMKTLLLLVGLLLTWDNGRVLGDQAVSDTELQEMSTEGSKYINKEIKNALKGVKQIKTLIEQTNEERKSLLSNLEEAKKK KEDALNDTKDSETKLKASQGVCNDTMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWMNGDRID SLLENDRQQTHALDVMQDSFNRASSIMDELFQDRFFTREPQDTYHYSPFSLFQRRPFFNPKFRIARNIIPFPRFQPLNFH DMFQPFFDMIHQAQQAMDVNLHRIPYHFPIEFPEEDNRTVCKEIRHNSTGCLKMKDQCEKCQEILSVDCSSNNPAQVQLR QELSNSLQIAEKFTKLYDELLQSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSEDPFYLQVTTVGSQTSDSNVPVGFTK VVVKLFDSDPITVMIPEAVSRNNPKFMETVAEKALQEYRQKHREE >NP_999136.1 clusterin precursor [Sus scrofa] MKTLLLLVGLLLTWENGPWVLGDKAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTLIEQSNEERKSLLSSLEEAKKK KEDALNDTRDTETKLKGSQGLCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRID SLMENDRQQSHVMDIMEDSFNRASNIMDELFQDRFFNREPFDTQFFSPFGSSHRGSLFFNPKSRFARNIMPFPLFTDLNY HDMFQPFFDMIHQAQQAMDAHLHRIPYHFPEAGVPENSNDRAVCKEIRHNSTGCLRMKDQCEKCREILSVDCSASNSSQM QLRQELYTSLQMAEKFSKLYDQLLQSYQQKMLNTSSLLKQLNEQFSWVSQLANLTQNDDRYYLQVTTVNSHGSDPSVPSG LTKVVVKLFDSYPITLIIPQEVSDPKFMETVAEEALQQYRQRSREE >XP_038948927.1 clusterin isoform X2 [Rattus norvegicus] MKILLLCVALLLTWDNGMVLGEQEFSDNELQELSTQGSRYVNKEIQNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKK EGALDDTRDSEMKLKAFPEVCNETMMALWEECKPCLKHTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDS LLESDRQQSQVLDAMQDSFTRASGIIDTLFQDRFFTHEPQDIHHFSPMGFPHKRPHFLYPKSRLVRSLMPLSHYGPLSFH NMFQPFFDMIHQAQQAMDVQLHSPALQFPDVDFLKEGEDDRTVCKEIRHNSTGCLKMKGQCEKCQEILSVDCSTNNPAQA NLRQELNDSLQVAERLTQQYNELLHSLQSKMLNTSSLLEQLNDQFSWVSQLANLTQGDDQYLRVSTVTTHSSDSEVPSRV TEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSR >NP_038520.2 clusterin preproprotein [Mus musculus] MKILLLCVALLLIWDNGMVLGEQEVSDNELQELSTQGSRYINKEIQNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKK EDALEDTRDSEMKLKAFPEVCNETMMALWEECKPCLKHTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWMNGDRIDS LLESDRQQSQVLDAMQDSFARASGIIDTLFQDRFFARELHDPHYFSPIGFPHKRPHFLYPKSRLVRSLMSPSHYGPPSFH NMFQPFFEMIHQAQQAMDVQLHSPAFQFPDVDFLREGEDDRTVCKEIRRNSTGCLKMKGQCEKCQEILSVDCSTNNPAQA NLRQELNDSLQVAERLTEQYKELLQSFQSKMLNTSSLLEQLNDQFNWVSQLANLTQGEDKYYLRVSTVTTHSSDSEVPSR VTEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSRAE >XP_017907364.1 PREDICTED: clusterin [Capra hircus] MKTLLLLVGLLLSWESGRAISDKELQEMSAEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND REQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARSVMPFPLLEPLNFHDVFQP FYDMIRQAQQAMDAHLQRTPYHFPVTEFTENNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTLLRQQLN ASLQLAEKFSRLYDQLLQSYQQKMLDTSALLKQLNEQFTWVSQLANLTQSDDQYYLQVFTVNSHSSDPSIPSGLTKVVVK LFNSLPITVTVPQEVSNPNFMENVAEKALQQYRRKSHEE >KAF4025298.1 hypothetical protein G4228_017406 [Cervus hanglu yarkandensis] MKTLLLLVGLLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKSLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND RQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQP FYDMIYQAQQAMDAHLRRSPYQFPMEEFTANNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLN ASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSHNSDPSIPSGLTKVVVK LFNSFPITVMVPQEVSSPRFMENVAEKALQQYRRKSL >XP_004004480.1 clusterin [Ovis aries] MKTLLLLVGLLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND REQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPLNFHDVFQP FYDMIRQAQQAMDAHLQRTPYHFPVTEFTENNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTLLRQQLN TSLQLAEKFSRLYDQLLQSYQQKMLDTSTLLKQLNEQFTWVSQLANLTQSDDQYYLQVFTVNSHSSDPSIPSGLTKVVVK LFNSFPITVTVPQEVSSPNFMENVAEKALQQYRRKSHEE >XP_043343022.1 clusterin [Cervus canadensis] MKTLLLLVGLLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKSLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND RQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQP FYDMIYQAQQAMDAHLRRSPYQFPMEEFTANNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLN ASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSHNSDPSIPSGLTKVVVK LFNSFPITVMVPQEVSSPHFMEDVAEKALQQYRRKSLEE >XP_043747136.1 clusterin [Cervus elaphus] MKTLLLLVGLLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND RQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQP FYDMIYQAQQAMDAHLRRSPYQFPMEEFTANNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLN ASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSHNSDPSIPSGLTKVVVK LFNSFPITVMVPQEVSSPHFMEDVAEKALQQYRRKSLEE >KAB0368575.1 hypothetical protein FD755_019609 [Muntiacus reevesi] MKTLLLLVALLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND RQQSHVMDVMEDSFTRASSIMDEFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMI YQAQQAMDAHLRRSPYQFPMEEFTANNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQL AEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANVTQGDDQYYLQVSTVNSHNSDPSIPSGLTKVVVKLFNSF PITVMVPQEVSSPHFMENVAEKALQQYRRKSLEE >NP_776327.1 clusterin preproprotein [Bos taurus] MKTLLLLMGLLLSWESGWAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND REQSHVMDVMEDSFTRASSIMDELFQDRFFLRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPFNFHDVFQP FYDMIHQAQQAMDAHLQRTPYHFPTMEFTENNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASNPTQTLLRQQLN ASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQSDDQHYLQVFTVNSHNSDPSIPSGLTKVIVK LFNSFPITVTVPQEVSSPNFMENVAEKALQQYRRKSQEE >XP_020733543.1 clusterin isoform X2 [Odocoileus virginianus texanus] MKTLLLLVGLLLSWESGRAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALN DTRDSENKLKASQGVCNETMLALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMEND RQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTHYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQP FYDMIYQAQQAMDAHLRRSPYQFPMEEFTANNDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLN TSLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSHNSDPSVPSGLTKVVLK LFNFFPITVMVPQEVSSPHFMENVAEKALQQYRRKSLEE >KAB0365458.1 hypothetical protein FD754_009614 [Muntiacus muntjak] MSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEEC KPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDEFFPR RPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMEEFTANN DRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLK QLNEQFTWVSQLANVTQGDDQYYLQVSTVNSHNSDPSIPSGLTKVVVKLFNSFPVTVMVPQEVSSPHFMENVAEKALQQY RRKSLEE >XP_021135541.1 LOW QUALITY PROTEIN: clusterin [Columba livia] MSAAGSKYIDTEVENAINGVKQMKTLMDKTSKDHQAILHTLEETKRRKEVSEDEEGGGTRAGMDKEQQLAAKQEVCNETM LALWEECKPCLKHTCMRFYSRTCHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDSLLERDQRQERQFEDLEERFGLLEDE VDDIFQDSTQVYGRIHPFFPAPFGGFREAFRPPVQRVRLVPRSQRFSRELHPLFPHPHHSFHRLFQPLFEMTQRMLDEVQ GGWERPMGTLGSESRNFSDDRMVCREIRRNSAGCLRMRDEXEKCRDILAVAPFVRPPLFQVLSKAPNPSDPLAPPDTQVT VQLFDSEPLSLTVPGDISWDDPRFMELVAEQALRHYKQNAIE
Mafft alignment of selected proteins >sp|P10909|CLUS_HUMAN Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1 ----------------------------------------------------MM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSNQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >sp|P10909-2|CLUS_HUMAN Isoform 2 of Clusterin OS=Homo sapiens OX=9606 GN=CLU MQVCSQPQRGCVREQSAINTAPPSAHNAASPGGARGHRVPLTEACKDSRIGGMM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSNQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >sp|P10909-3|CLUS_HUMAN Isoform 3 of Clusterin OS=Homo sapiens OX=9606 GN=CLU ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----MQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >sp|P10909-4|CLUS_HUMAN Isoform 4 of Clusterin OS=Homo sapiens OX=9606 GN=CLU ------------------------------------------------------------ ------------------------------------MSNQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >sp|P10909-5|CLUS_HUMAN Isoform 5 of Clusterin OS=Homo sapiens OX=9606 GN=CLU -----------------------------------------MEACKDSRIGGMM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSNQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >sp|P10909-6|CLUS_HUMAN Isoform 6 of Clusterin OS=Homo sapiens OX=9606 GN=CLU ------------------------------------------------------------ -------------------MGDQTVSDN----ELQEMSNQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAK LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >tr|Q5SPR2|Q5SPR2_DANRE Clusterin OS=Danio rerio OX=7955 GN=clu PE=3 SV=1 ----------------------------------------------------MM-----K VLWSLLGL-FLLYL-----STECLLPPSK--EELNQMSQVGEKYLDRQIENAISGVKEMK TVMERSEEEHKRMLSEMEKTQKEKENA-------LKMAQEMKEKLSEEQSVCNETMEALW EECKPCLRKTCVKFYSRTCRSGSGLVGRQLEEILNRTSPISIFINGQSIETLLSEDQQQT RHFQDLEESYTEVSDGVENMFTDSMKVFDHMQMFHHPGF---------FPSRFQFPSMFG GHEGSTHAGRIYRSPMHD--SLFHSLQSLFRPM-----------ERSMSMFGKNEERNFT SEGWKLNE-----KVTTDDKMTCKEIRRNSFGCVKLKDECEKCQQIQHIDCSGKRPLEGP LKEELERALGKAEEFTQEFNNLLNIFQEQMFNTSSLLDLFNKQFGWVSSLANHTQNE--- -DGFFQIQAVMS--KG-----SDNAENPAD-TRVSVKLFDGPDMIYTVPGDIPWSDPKFS EVVAQEALDRYKQNAVITKL >XP_015803151.1 PREDICTED: clusterin [Nothobranchius furzeri] -----------------------------------------MLI-----IMMMMKKKGSK ESLAVMALALLS-------SASCILPPSR--EDLNEISVQGERYLDKQIENAIGGVKEMK NVMQKSSEDHKKFLDALEKTKQQKEEA-------IRTAEEMEAKLEKEEEVCNETMKALW EECKPCLKNTCIKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWINGERIDTLEQEGRRQS KKFRNVEEKYTEMSEGVESIFSDSMKVADHVH-----------------PPMFFFPRFLA ---PVMRRSRSI-HTLFH--DPFHNFQSLFSPM--MGRN----LFGSMDAMTDLDSDTPT NQDGSVNEDVIITRPFGSGKMTCREIRRNSAGCIKFRDECEKCKEIQHLDCSGKKPLEGP LKEELEEALAMAERFTQQYNVLLKRFEEQMFNTSSILDLLNKQFGWVSSLANNTQ----- -DGIFHVKVVATGPEV-----QSGEKEPAD-TRVSVQLFDSPSMNFTISGDIPWTDPKFS EVVAQEALDRYKETSVLVK- >XP_030261895.1 clusterin isoform X1 [Sparus aurata] -----------------------------------------MLM-----MMMMMKKKKAS KILAVVAL-LVA-------TVNGVLLPTK--EDLYQISLQGEKYLDRQIENAVNGVKEMK TVMQKSSEDHQKLLDALEKTKEQKEEA-------MRAAQEMETKLEQEEEVCNETMKTLW EECKPCLKNTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWINGEKIDVLEQEGQRQS KEFRNLEEKYTEMADGVDSIFTDSMKVADHVHY---------------NPPVFYLPNFLG ---PYARQTRSI-RSLFR--DPFHGFQNLFSPMSGMSRN----FFSSMGSMMDMDSDTPP NEDGSVNEDVVITKPFGNGRMTCREIRRNSAGCLRFREECQKCKEIQHIDCSGKRPLEGP LKEELEEALAMAERFTQLYNNLLTRFEEQMVNTSSLLDMLNSQFGWVSSLANNTK----- -DNIFQVQTVLC--KDTEEKPAGEEKQHEE-TAVSVQVFDSPPMNVSVPGDIPWTDPKFS EVVAQKALDRYKETSVMVK- >XP_011490335.1 clusterin isoform X2 [Oryzias latipes] -----------------------------------------MLM-----MMMMMRKKGSK ESLAMLAL-LLA-------SASSILPPSE--KDLNEISQQGERYLDTQIENAITGVKKMK EVMQKSTEDHNKFLDALQKKKQQKEEA-------IREAQEMEAKLVHEEEACNETMKALW EECKPCLKTTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWVNGERIDTLEQEGQQQN KEFKNLEERYTEMADGVDSIFSDSMKVADHIHL---------------NPPVFFFPHFLS ---PYARRARSI-RSLFQ--DPFHNFQSLFSPM--MGRN----FF---DSMMDMSSDPVP NEDGDVNEDVVVTKPFGNGRMTCREIRRNSAGCIKFRNECEKCKEIQHLDCDGKKPLEGP LKEELEEALATAERFTQQYTSLLQRMEEQLFNTSSILDMFNKQFGWVSTLANSTK----- -DGLFRVKAVIS--RD-----SPTEEKPAE-TSVEVQLFDSPPMTFTVPGEIPWTDPKFS EVVAQEALDRYKEISVVVK- >XP_006033945.1 clusterin [Alligator sinensis] ----------------------------------------------------MA-----L LLLSLLGL-LLTWE-----GGQAVIPTS----ELKQLSVAGSKYLDTEIENAINGVKQMK TLMDKTSKDHQAILDTLEETKQQKEEA-------MRQARQKEQLLSETRDVCNETVLALW EECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWVDGERVDSLLDEDKQQG RWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFAGGFQEA--LRSPFRSPRL-- ---PSTRVVRDLPSPFFRLHDPTQSFQHLFQPLFEMTQRMFEGAQRAMENDRHWFGKGWD SLPGGVSTE---TYNTSDARMVCREIRRNSAGCLKMKDRCEKCKEILAVDCS--DPAHSQ LREQFEDALRIAERFSHRYDELLEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGSGR DDGFFQVTTVLS--KTPD---PRDPSLPAD-TQVTVQIFDSEPLVLTVPGDISWDDPKFM EVVADEALRLYKQNNVV--- >KYO32283.1 clusterin [Alligator mississippiensis] -----------------------------------------------------------M QALGRGGA-QLGRS-----PEQRAQPGSYRVCELKQLSVAGSKYLDTEIENAINGVKQMK SLMDKTSKDHQAILDTLEETKQQKEEA-------MRQARQKEQLLSETRDVCNETVLALW EECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWMDGERVDSLLDEDKQQS RWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFAGGFQEA--LRSPFRSPRL-- ---PSTRVVRDLPSPFFRLHDPTQSFQHLFQPLFEMTQRMFEGAQRAMENDRHWFGKGWD SLPGGVSTE---TYNTSDARMVCREIRRNSAGCLKMKDQCEKCKEILAVDCS--DPAHSQ LREQFEDALRIAERFSHRYDELMEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGSGR NDGFFQVTTVLS--KTPD---PRDPSLPAD-TQVTVQIFDSEPLVLTVPGDISWDDPKFM EVVADEALRLYKQNNVV--- >NP_001383106.1 clusterin precursor [Gallus gallus] ----------------------------------------------------MA-----L PLLALLSL-GLVCQ-----GGQGLVPPS----ELKQLSAAGSKYIDTEVENAINGVKQMK TLMDKTSKEHQAMLHTLEETKRRKEEA-------VKLALEKEKQLAEKQEVCNETMLSLW EECKPCLKHTCMRVYSKICHSGSGLVGRQLEELLNRSSPFSIWVNGERIDALLDREQRQE RRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFGGFREA--FVPPVQRVRLVP ---PRRRLSREL-HPFLQ--HPVHGFHR----LFEMTQRMLDGGHGA-----------WD HLLGGFESE---SRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQ LREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLGNLTQGT--- -DGFLQVTTVFS--KTPN---LEDPSAPAD-TQVTVQLFDSEPLSLTVPGDISWDDPRFM EIVAEQALQHFKQNNTIE-- >XP_010706357.1 LOW QUALITY PROTEIN: clusterin [Meleagris gallopavo] ----------------------------------------------------MA-----L LLLALLSL-GLVCQ-----GGQGLMPPS----ELKQLSAAGSKYIDTEVENAINGVKQMK TLMDKTSKEHQAMLHTLEETKRKKEEA-------VKLALEKEKQLAEKQDVCNESMLSLW EECKPCLKHTCMRVYSKICHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDELLDREQRQE RRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFGGFREX--FVPPVQRVHLV- ---PRRRLSREL-HPFFQ--HPVHGFHRLFQPLFEMTQRMLDGGHGA-----------WE HPLGGFASE---PRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQ LREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLKNLTQGT--- -DGFLQVTTVFS--KTPN---LEDPSAPAD-TQVTVQLFDSEPLSLTVPGDISWDDPRFM EIVAEQALQHYKQKNTIE-- >XP_040204262.1 clusterin [Rana temporaria] --------------------------------------------------MRMV-----P LSLLLVAV-LLN-------FTGALLPPE----SLKKISEEGRKYITEQFENAVNGVRQMK KLMDQTGEEHQKILRTLEETKKNKEDA-------LKQALESEQQLSETQEICNDTMLALW EECKPCLKQTCVRFYSKTCRSGSGLVGRQLEDFLNRSSPFAIWVNGERIDTLNKQDEQQH MALEDLEDGYSIVEDSVHELFQDSMKAFDHMKPLFSKPFH-GFSFPQWEQFPFQKISTPV ---SAMRIRKER-SPLFE-PFFTSNFDSLFEA-----------AQKMMEKHRQMIQ-QGP QFDGM--------NNSTDDKTVCRELRRNTAGCLRMKDKCEKCKEILAVDCSGKNTMQEK LREKFEDSVRLAEKYTTLYDDLLQRFREKMLNTTGLLEDLSHQYSWVSKLANLTDND--- LKGIFQMSTAYS----------SSGGAPSD-TTVTVKLFDSESFTFTVPGHISMEDPTFG ELVAEEALKRFKKEVIEAA- >NP_001080775.1 clusterin precursor [Xenopus laevis] --------------------------------------------------MNMY-----K FPFLLVGL-LVG-------LSAAVLPPE----NLNQISIEGSRYITEQVENAVNGVKKMK SIMDQTGKEHQEIMRNLEETKKNKEEA-------LKRALDTEQELEEKKEVCNETMLALW EECKPCLKQTCVRFYSKTCRSGSGLVGRQFEEFLNRSSPFSIFINGEKINSLTQEGEQQH MTLDDLEGGYSLVEDSVDELFRESIKAFGQMKPFFSNSFHNGFFESQWNPFPFQRVGFPF ---SESRQAR---SPTFN-PYFSGNFESLIEA-----------AQKMMERSHHFV----P RLDGLGSIRG--NGNDSDDKLVCKELRRNSASCLKMQEKCEKCKEILAVDCTGKDPVQEH LQEVFQDSLRLAEKFTRQYDDLLEQFREKMFNTTGILEQLNKQFGWLSKFANMTQSG--- KNGIFQVSTIYS----------KEGESPSD-TKVTVNVFDSDPITFTLPGYISMDDPMFG ELVAEEALKKFKTEVVEAA- >XP_004046872.3 clusterin isoform X1 [Gorilla gorilla gorilla] ----------------------------------------------------MM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSDQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRVSSIMDKLFQDRFFTREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQAQ LRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >NP_001075518.1 clusterin precursor [Oryctolagus cuniculus] -----------------------------------------------------M-----K TLLLCVGL-LLSWERGQ-VLGDQLVSDN----ELQEMSTQGSKYIDREIQNAVKGVQEIK TLIEKTNEERKTLLSVLEEAKKNKEDA-------LNETRDSETKLKAFPEVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWINGDRIDSLLENDRQQS HVLDVMQDSFNRATGIMDELFQDRFFTHKPQDTFYHSPFS----------Y-FRRPPLHY ---AKSRLVRNI-MPLSL--YGPLNFQDMFQPFFEMIHQ----AQQAMDVHLHSPAYQTP NVEFI--------TGGPDDRAVCKEIRHNSTGCLRMKDQCAKCQEILSVDCSANNPSQNQ LRQELNDSLRLAEELTKRYNELLQSYQWKMLNTSSLLDQPNEQFNWVSQLANLTQGP--- DQYYLRVSTVTS--HT------SESEAPSRVTEVVVKLFDSDPITITIPEEVSRDNPKFM ETVAEKALQEYRKKKRVE-- >XP_003984849.1 clusterin [Felis catus] -----------------------------------------------------M-----K TLLLLVGL-LLTCENGR-VLGDKAVSDA----ELQEMSTEGSKYINKEIKNALKGVKQIK TLIEQTNEERKSLLSNLEEAKKKKEDA-------LSDTKDSEMKLKASEGVCNDTMMALW EECKPCLKQTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWINGDRIDSLLENDRQQT HALDVMQDSFNRASRIMDELFQDRFFTREPQDTYHYSPFS----------SLQRRPFFFN ---PKSRFARNV-MPFPA--FQPLNFHDMFQPFFDMIHQ----AQQAMDINLQRIPYHFP -MEFT--------EEDNQDRMVCKEIRHNSTGCLRMKDQCDKCQEILSVDCSASNPSQVL LRQELNNSLQMAEKFTKLYDELLRSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSE--- DPFYLQVTTVSS--QT------SDSNVPSGFTKVVVKLFDSDPISVMVPEEVSRNNPKFM ETVAEKALQEYRQKNGEK-- >XP_003777274.1 clusterin isoform X2 [Pongo abelii] ----------------------------------------------------MM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSDQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKEFPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIMDELFQDRFFAQEPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIIRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDVHFHSPAFQLP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQAQ LRRELNESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANVTQGK--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >XP_001164647.1 clusterin isoform X2 [Pan troglodytes] ----------------------------------------------------MM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSDQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSASNPSQAQ LRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDIPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >XP_034821769.1 clusterin isoform X2 [Pan paniscus] -----------------------------------------MEACKDSRIGGMM-----K TLLLFVGL-LLTWESGQ-VLGDQTVSDN----ELQEMSDQGSKYVNKEIQNAVNGVKQIK TLIEKTNEERKTLLSNLEEAKKKKEDA-------LNETRESETKLKELPGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFS----------LPHRRPHFFF ---PKSRIVRSL-MPFSP--YEPLNFHAMFQPFLEMIHE----AQQAMDIHFHSPAFQHP PTEFI--------REGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSASNPSQAQ LRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGE--- DQYYLRVTTVAS--HT------SDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFM ETVAEKALQEYRKKHREE-- >NP_001003370.1 clusterin precursor [Canis lupus familiaris] ----------------------------------------------------MM-----K TLLLLVGL-LLTWDNGR-VLGDQAVSDT----ELQEMSTEGSKYINKEIKNALKGVKQIK TLIEQTNEERKSLLSNLEEAKKKKEDA-------LNDTKDSETKLKASQGVCNDTMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQT HALDVMQDSFNRASSIMDELFQDRFFTREPQDTYHYSPFS----------LFQRRP-FFN ---PKFRIARNI-IPFPR--FQPLNFHDMFQPFFDMIHQ----AQQAMDVNLHRIPYHFP -IEFP--------EE--DNRTVCKEIRHNSTGCLKMKDQCEKCQEILSVDCSSNNPAQVQ LRQELSNSLQIAEKFTKLYDELLQSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSE--- DPFYLQVTTVGS--QT------SDSNVPVGFTKVVVKLFDSDPITVMIPEAVSRNNPKFM ETVAEKALQEYRQKHREE-- >NP_999136.1 clusterin precursor [Sus scrofa] -----------------------------------------------------M-----K TLLLLVGL-LLTWENGPWVLGDKAISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TLIEQSNEERKSLLSSLEEAKKKKEDA-------LNDTRDTETKLKGSQGLCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDIMEDSFNRASNIMDELFQDRFFNREPFDTQFFSPFG----------SSHRGSLFFN ---PKSRFARNI-MPFPL--FTDLNYHDMFQPFFDMIHQ----AQQAMDAHLHRIPYHFP EAGVP--------EN-SNDRAVCKEIRHNSTGCLRMKDQCEKCREILSVDCSASNSSQMQ LRQELYTSLQMAEKFSKLYDQLLQSYQQKMLNTSSLLKQLNEQFSWVSQLANLTQND--- DRYYLQVTTVNS--HG------SDPSVPSGLTKVVVKLFDSYPITLIIPQEVS--DPKFM ETVAEEALQQYRQRSREE-- >XP_038948927.1 clusterin isoform X2 [Rattus norvegicus] -----------------------------------------------------M-----K ILLLCVAL-LLTWDNGM-VLGEQEFSDN----ELQELSTQGSRYVNKEIQNAVQGVKHIK TLIEKTNAERKSLLNSLEEAKKKKEGA-------LDDTRDSEMKLKAFPEVCNETMMALW EECKPCLKHTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLESDRQQS QVLDAMQDSFTRASGIIDTLFQDRFFTHEPQDIHHFSPMG----------FPHKRPHFLY ---PKSRLVRSL-MPLSH--YGPLSFHNMFQPFFDMIHQ----AQQAMDVQLHSPALQFP DVDFL--------KEGEDDRTVCKEIRHNSTGCLKMKGQCEKCQEILSVDCSTNNPAQAN LRQELNDSLQVAERLTQQYNELLHSLQSKMLNTSSLLEQLNDQFSWVSQLANLTQGD--- DQ-YLRVSTVTT--HS------SDSEVPSRVTEVVVKLFDSDPITVVLPEEVSKDNPKFM DTVAEKALQEYRRKSR---- >NP_038520.2 clusterin preproprotein [Mus musculus] -----------------------------------------------------M-----K ILLLCVAL-LLIWDNGM-VLGEQEVSDN----ELQELSTQGSRYINKEIQNAVQGVKHIK TLIEKTNAERKSLLNSLEEAKKKKEDA-------LEDTRDSEMKLKAFPEVCNETMMALW EECKPCLKHTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWMNGDRIDSLLESDRQQS QVLDAMQDSFARASGIIDTLFQDRFFARELHDPHYFSPIG----------FPHKRPHFLY ---PKSRLVRSL-MSPSH--YGPPSFHNMFQPFFEMIHQ----AQQAMDVQLHSPAFQFP DVDFL--------REGEDDRTVCKEIRRNSTGCLKMKGQCEKCQEILSVDCSTNNPAQAN LRQELNDSLQVAERLTEQYKELLQSFQSKMLNTSSLLEQLNDQFNWVSQLANLTQGE--- DKYYLRVSTVTT--HS------SDSEVPSRVTEVVVKLFDSDPITVVLPEEVSKDNPKFM DTVAEKALQEYRRKSRAE-- >XP_017907364.1 PREDICTED: clusterin [Capra hircus] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSAEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMTALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARSV-MPFPL--LEPLNFHDVFQPFYDMIRQ----AQQAMDAHLQRTPYHFP VTEFT--------EN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLDTSALLKQLNEQFTWVSQLANLTQSD--- DQYYLQVFTVNS--HS------SDPSIPSGLTKVVVKLFNSLPITVTVPQEVS--NPNFM ENVAEKALQQYRRKSHEE-- >KAF4025298.1 hypothetical protein G4228_017406 [Cervus hanglu yarkandensis] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKSLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGD--- DQYYLQVSTVNS--HN------SDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPRFM ENVAEKALQQYRRKSL---- >XP_004004480.1 clusterin [Ovis aries] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMTALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPLNFHDVFQPFYDMIRQ----AQQAMDAHLQRTPYHFP VTEFT--------EN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTL LRQQLNTSLQLAEKFSRLYDQLLQSYQQKMLDTSTLLKQLNEQFTWVSQLANLTQSD--- DQYYLQVFTVNS--HS------SDPSIPSGLTKVVVKLFNSFPITVTVPQEVS--SPNFM ENVAEKALQQYRRKSHEE-- >XP_043343022.1 clusterin [Cervus canadensis] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKSLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGD--- DQYYLQVSTVNS--HN------SDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFM EDVAEKALQQYRRKSLEE-- >XP_043747136.1 clusterin [Cervus elaphus] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGD--- DQYYLQVSTVNS--HN------SDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFM EDVAEKALQQYRRKSLEE-- >KAB0368575.1 hypothetical protein FD755_019609 [Muntiacus reevesi] -----------------------------------------------------M-----K TLLLLVAL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDE-----FFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANVTQGD--- DQYYLQVSTVNS--HN------SDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFM ENVAEKALQQYRRKSLEE-- >NP_776327.1 clusterin preproprotein [Bos taurus] -----------------------------------------------------M-----K TLLLLMGL-LLSWESGW------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMTALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQS HVMDVMEDSFTRASSIMDELFQDRFFLRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPFNFHDVFQPFYDMIHQ----AQQAMDAHLQRTPYHFP TMEFT--------EN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASNPTQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQSD--- DQHYLQVFTVNS--HN------SDPSIPSGLTKVIVKLFNSFPITVTVPQEVS--SPNFM ENVAEKALQQYRRKSQEE-- >XP_020733543.1 clusterin isoform X2 [Odocoileus virginianus texanus] -----------------------------------------------------M-----K TLLLLVGL-LLSWESGR------AISDK----ELQEMSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMLALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTHYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNTSLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGD--- DQYYLQVSTVNS--HN------SDPSVPSGLTKVVLKLFNFFPITVMVPQEVS--SPHFM ENVAEKALQQYRRKSLEE-- >KAB0365458.1 hypothetical protein FD754_009614 [Muntiacus muntjak] ------------------------------------------------------------ ------------------------------------MSTEGSKYVNKEIKNALKEVKQIK TQIEQTNEERKLLLSSLEEAKKKKEDA-------LNDTRDSENKLKASQGVCNETMMALW EECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQS HVMDVMEDSFTRASSIMDE-----FFPRRPQDTQYYSPFS----------SFPRGSLFFN ---PKSRFARNV-MPFPL--LEPINFHDVFQPFYDMIYQ----AQQAMDAHLRRSPYQFP MEEFT--------AN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTL LRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANVTQGD--- DQYYLQVSTVNS--HN------SDPSIPSGLTKVVVKLFNSFPVTVMVPQEVS--SPHFM ENVAEKALQQYRRKSLEE-- >XP_021135541.1 LOW QUALITY PROTEIN: clusterin [Columba livia] ------------------------------------------------------------ ------------------------------------MSAAGSKYIDTEVENAINGVKQMK TLMDKTSKDHQAILHTLEETKRRKEVSEDEEGGGTRAGMDKEQQLAAKQEVCNETMLALW EECKPCLKHTCMRFYSRTCHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDSLLERDQRQE RQFEDLEERFGLLEDEVDDIFQDSTQVYGRIHPFFPAPF-GGFREA--FRPPVQRVRLVP ---RSQRFSREL-HPLFP--HPHHSFHRLFQPLFEMTQRMLDEVQGG-----------WE RPMGTLGSE---SRNFSDDRMVCREIRRNSAGCLRMRDEXEKCRDILAVAPFVRPPL--- ------------------------------------------------------------ ----FQ---VLS--KAPN---PSDPLAPPD-TQVTVQLFDSEPLSLTVPGDISWDDPRFM ELVAEQALRHYKQNAIE---
BMGE Cleaned alignment of selected proteins >sp|P10909|CLUS_HUMAN Clusterin OS=Homo sapiens OX=9606 GN=CLU PE=1 SV=1 KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-2|CLUS_HUMAN Isoform 2 of Clusterin OS=Homo sapiens OX=9606 GN=CLU KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-3|CLUS_HUMAN Isoform 3 of Clusterin OS=Homo sapiens OX=9606 GN=CLU ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------MQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-4|CLUS_HUMAN Isoform 4 of Clusterin OS=Homo sapiens OX=9606 GN=CLU ------------------------------MSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-5|CLUS_HUMAN Isoform 5 of Clusterin OS=Homo sapiens OX=9606 GN=CLU KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >sp|P10909-6|CLUS_HUMAN Isoform 6 of Clusterin OS=Homo sapiens OX=9606 GN=CLU -----------------MGDQTVSDNELQEMSNQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIIDELFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSTNNPSQAKLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >tr|Q5SPR2|Q5SPR2_DANRE Clusterin OS=Danio rerio OX=7955 GN=clu PE=3 SV=1 KVLWSLLGLFLLYL---STECLLPPSELNQMSQVGEKYLDRQIENAISGVKEMKTVMERSEEEHKRMLSEMEKTQKEKENALKMAQEMKEKLSEEQSVCNETMEALWEECKPCLRKTCVKFYSRTCRSGSGLVGRQLEEILNRTSPISIFINGQSIETLLSEDQQQTRHFQDLEESYTEVSDGVENMFTDSMKVFDHMQMFHHPGF-SRFQFPSMFGGSTHAGRIYSPMHDSLFHSLQSLFRPM-------ERSMSMFGKNEERNFTSKVTTDDKMTCKEIRRNSFGCVKLKDECEKCQQIQHIDCSGKRPLEGPLKEELERALGKAEEFTQEFNNLLNIFQEQMFNTSSLLDLFNKQFGWVSSLANHTQNE-DGFFQIQAVMSDNAENPAD-TRVSVKLFDGPDMIYTVPGDIPWSDPKFSEVVAQEALDRYKQNAVIT >XP_015803151.1 PREDICTED: clusterin [Nothobranchius furzeri] KESLAVMALLLS-----SASCILPPSDLNEISVQGERYLDKQIENAIGGVKEMKNVMQKSSEDHKKFLDALEKTKQQKEEAIRTAEEMEAKLEKEEEVCNETMKALWEECKPCLKNTCIKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWINGERIDTLEQEGRRQSKKFRNVEEKYTEMSEGVESIFSDSMKVADHVH--------PMFFFPRFLAPVMRRSRSIHTLFHDPFHNFQSLFSPM--MGRNLFGSMDAMTDLDSDTPTNRPFGSGKMTCREIRRNSAGCIKFRDECEKCKEIQHLDCSGKKPLEGPLKEELEEALAMAERFTQQYNVLLKRFEEQMFNTSSILDLLNKQFGWVSSLANNTQ---DGIFHVKVVATSGEKEPAD-TRVSVQLFDSPSMNFTISGDIPWTDPKFSEVVAQEALDRYKETSVLV >XP_030261895.1 clusterin isoform X1 [Sparus aurata] SKILAVVALLVA-----TVNGVLLPTDLYQISLQGEKYLDRQIENAVNGVKEMKTVMQKSSEDHQKLLDALEKTKEQKEEAMRAAQEMETKLEQEEEVCNETMKTLWEECKPCLKNTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWINGEKIDVLEQEGQRQSKEFRNLEEKYTEMADGVDSIFTDSMKVADHVHY-------PVFYLPNFLGPYARQTRSIRSLFRDPFHGFQNLFSPMSGMSRNFFSSMGSMMDMDSDTPPNKPFGNGRMTCREIRRNSAGCLRFREECQKCKEIQHIDCSGKRPLEGPLKEELEEALAMAERFTQLYNNLLTRFEEQMVNTSSLLDMLNSQFGWVSSLANNTK---DNIFQVQTVLCGEEKQHEE-TAVSVQVFDSPPMNVSVPGDIPWTDPKFSEVVAQKALDRYKETSVMV >XP_011490335.1 clusterin isoform X2 [Oryzias latipes] KESLAMLALLLA-----SASSILPPSDLNEISQQGERYLDTQIENAITGVKKMKEVMQKSTEDHNKFLDALQKKKQQKEEAIREAQEMEAKLVHEEEACNETMKALWEECKPCLKTTCVKYYSRTCSSGSGLVGRQLEDVLNRTSPFSIWVNGERIDTLEQEGQQQNKEFKNLEERYTEMADGVDSIFSDSMKVADHIHL-------PVFFFPHFLSPYARRARSIRSLFQDPFHNFQSLFSPM--MGRNFF---DSMMDMSSDPVPNKPFGNGRMTCREIRRNSAGCIKFRNECEKCKEIQHLDCDGKKPLEGPLKEELEEALATAERFTQQYTSLLQRMEEQLFNTSSILDMFNKQFGWVSTLANSTK---DGLFRVKAVISPTEEKPAE-TSVEVQLFDSPPMTFTVPGEIPWTDPKFSEVVAQEALDRYKEISVVV >XP_006033945.1 clusterin [Alligator sinensis] LLLLSLLGLLLTWE---GGQAVIPTSELKQLSVAGSKYLDTEIENAINGVKQMKTLMDKTSKDHQAILDTLEETKQQKEEAMRQARQKEQLLSETRDVCNETVLALWEECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWVDGERVDSLLDEDKQQGRWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFASPFRSPRL--PSTRVVRDLSPFFRDPTQSFQHLFQPLFEMTQRAQRAMENDRHWFGKGWDSYNTSDARMVCREIRRNSAGCLKMKDRCEKCKEILAVDCS--DPAHSQLREQFEDALRIAERFSHRYDELLEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGDDGFFQVTTVLSRDPSLPAD-TQVTVQIFDSEPLVLTVPGDISWDDPKFMEVVADEALRLYKQNNVV- >KYO32283.1 clusterin [Alligator mississippiensis] MQALGRGGAQLGRS---PEQRAQPGSELKQLSVAGSKYLDTEIENAINGVKQMKSLMDKTSKDHQAILDTLEETKQQKEEAMRQARQKEQLLSETRDVCNETVLALWEECKPCLKQTCMRFYSKTCHSGSGLVGRQLEELLNHSSPFSIWMDGERVDSLLDEDKQQSRWLEDLEERYGLVEDSVDDLFQESTRAYGHLHPFFHSPFASPFRSPRL--PSTRVVRDLSPFFRDPTQSFQHLFQPLFEMTQRAQRAMENDRHWFGKGWDSYNTSDARMVCREIRRNSAGCLKMKDQCEKCKEILAVDCS--DPAHSQLREQFEDALRIAERFSHRYDELMEAFQQEMLNTSRLLDQLNRQFGWVSRLANLTQNGNDGFFQVTTVLSRDPSLPAD-TQVTVQIFDSEPLVLTVPGDISWDDPKFMEVVADEALRLYKQNNVV- >NP_001383106.1 clusterin precursor [Gallus gallus] LPLLALLSLGLVCQ---GGQGLVPPSELKQLSAAGSKYIDTEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKRRKEEAVKLALEKEKQLAEKQEVCNETMLSLWEECKPCLKHTCMRVYSKICHSGSGLVGRQLEELLNRSSPFSIWVNGERIDALLDREQRQERRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFPPVQRVRLVPPRRRLSRELHPFLQHPVHGFHR----LFEMTQRGHGA-----------WDHRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQLREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLGNLTQGT-DGFLQVTTVFSEDPSAPAD-TQVTVQLFDSEPLSLTVPGDISWDDPRFMEIVAEQALQHFKQNNTIE >XP_010706357.1 LOW QUALITY PROTEIN: clusterin [Meleagris gallopavo] LLLLALLSLGLVCQ---GGQGLMPPSELKQLSAAGSKYIDTEVENAINGVKQMKTLMDKTSKEHQAMLHTLEETKRKKEEAVKLALEKEKQLAEKQDVCNESMLSLWEECKPCLKHTCMRVYSKICHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDELLDREQRQERRFEDLEERFGLMEDGVEDIFQDSTQLYGPAFPFFRTPPFPPVQRVHLV-PRRRLSRELHPFFQHPVHGFHRLFQPLFEMTQRGHGA-----------WEHRNFSTDRMVCREIRRNSAGCLRMRDECEKCREILAVDCSQTDPVQSQLREQFEDALRLAERFTRRYDDLLSAFQAEMLNTSSLLDQLNRQFGWVSRLKNLTQGT-DGFLQVTTVFSEDPSAPAD-TQVTVQLFDSEPLSLTVPGDISWDDPRFMEIVAEQALQHYKQKNTIE >XP_040204262.1 clusterin [Rana temporaria] PLSLLLVAVLLN-----FTGALLPPESLKKISEEGRKYITEQFENAVNGVRQMKKLMDQTGEEHQKILRTLEETKKNKEDALKQALESEQQLSETQEICNDTMLALWEECKPCLKQTCVRFYSKTCRSGSGLVGRQLEDFLNRSSPFAIWVNGERIDTLNKQDEQQHMALEDLEDGYSIVEDSVHELFQDSMKAFDHMKPLFSKPFHFPFQKISTPVSAMRIRKERSPLFEFFTSNFDSLFEA-------AQKMMEKHRQMIQ-QGPQNNSTDDKTVCRELRRNTAGCLRMKDKCEKCKEILAVDCSGKNTMQEKLREKFEDSVRLAEKYTTLYDDLLQRFREKMLNTTGLLEDLSHQYSWVSKLANLTDNDLKGIFQMSTAYSSSGGAPSD-TTVTVKLFDSESFTFTVPGHISMEDPTFGELVAEEALKRFKKEVIEA >NP_001080775.1 clusterin precursor [Xenopus laevis] KFPFLLVGLLVG-----LSAAVLPPENLNQISIEGSRYITEQVENAVNGVKKMKSIMDQTGKEHQEIMRNLEETKKNKEEALKRALDTEQELEEKKEVCNETMLALWEECKPCLKQTCVRFYSKTCRSGSGLVGRQFEEFLNRSSPFSIFINGEKINSLTQEGEQQHMTLDDLEGGYSLVEDSVDELFRESIKAFGQMKPFFSNSFHFPFQRVGFPFSESRQAR--SPTFNYFSGNFESLIEA-------AQKMMERSHHFV----PRGNDSDDKLVCKELRRNSASCLKMQEKCEKCKEILAVDCTGKDPVQEHLQEVFQDSLRLAEKFTRQYDDLLEQFREKMFNTTGILEQLNKQFGWLSKFANMTQSGKNGIFQVSTIYSKEGESPSD-TKVTVNVFDSDPITFTLPGYISMDDPMFGELVAEEALKKFKTEVVEA >XP_004046872.3 clusterin isoform X1 [Gorilla gorilla gorilla] KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRVSSIMDKLFQDRFFTREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQAQLRRELDESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >NP_001075518.1 clusterin precursor [Oryctolagus cuniculus] KTLLLCVGLLLSWERGQLGDQLVSDNELQEMSTQGSKYIDREIQNAVKGVQEIKTLIEKTNEERKTLLSVLEEAKKNKEDALNETRDSETKLKAFPEVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWINGDRIDSLLENDRQQSHVLDVMQDSFNRATGIMDELFQDRFFTHKPQDTFYHSPFSY-FRRPPLHYAKSRLVRNIMPLSLYGPLNFQDMFQPFFEMIHQAQQAMDVHLHSPAYQTPNTGGPDDRAVCKEIRHNSTGCLRMKDQCAKCQEILSVDCSANNPSQNQLRQELNDSLRLAEELTKRYNELLQSYQWKMLNTSSLLDQPNEQFNWVSQLANLTQGPDQYYLRVSTVTSSESEAPSRVTEVVVKLFDSDPITITIPEEVSRDNPKFMETVAEKALQEYRKKKRVE >XP_003984849.1 clusterin [Felis catus] KTLLLLVGLLLTCENGRLGDKAVSDAELQEMSTEGSKYINKEIKNALKGVKQIKTLIEQTNEERKSLLSNLEEAKKKKEDALSDTKDSEMKLKASEGVCNDTMMALWEECKPCLKQTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWINGDRIDSLLENDRQQTHALDVMQDSFNRASRIMDELFQDRFFTREPQDTYHYSPFSSLQRRPFFFNPKSRFARNVMPFPAFQPLNFHDMFQPFFDMIHQAQQAMDINLQRIPYHFP-EEDNQDRMVCKEIRHNSTGCLRMKDQCDKCQEILSVDCSASNPSQVLLRQELNNSLQMAEKFTKLYDELLRSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSEDPFYLQVTTVSSSDSNVPSGFTKVVVKLFDSDPISVMVPEEVSRNNPKFMETVAEKALQEYRQKNGEK >XP_003777274.1 clusterin isoform X2 [Pongo abelii] KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKEFPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAQEPQDTYHYLPFSLPHRRPHFFFPKSRIIRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDVHFHSPAFQLPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSANNPSQAQLRRELNESLQVAERLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANVTQGKDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >XP_001164647.1 clusterin isoform X2 [Pan troglodytes] KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSASNPSQAQLRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDIPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >XP_034821769.1 clusterin isoform X2 [Pan paniscus] KTLLLFVGLLLTWESGQLGDQTVSDNELQEMSDQGSKYVNKEIQNAVNGVKQIKTLIEKTNEERKTLLSNLEEAKKKKEDALNETRESETKLKELPGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHMLDVMQDHFSRASSIMDELFQDRFFAREPQDTYHYLPFSLPHRRPHFFFPKSRIVRSLMPFSPYEPLNFHAMFQPFLEMIHEAQQAMDIHFHSPAFQHPPREGDDDRTVCREIRHNSTGCLRMKDQCDKCREILSVDCSASNPSQAQLRRELDESLQVAEKLTRKYNELLKSYQWKMLNTSSLLEQLNEQFNWVSRLANLTQGEDQYYLRVTTVASSDSDVPSGVTEVVVKLFDSDPITVTVPVEVSRKNPKFMETVAEKALQEYRKKHREE >NP_001003370.1 clusterin precursor [Canis lupus familiaris] KTLLLLVGLLLTWDNGRLGDQAVSDTELQEMSTEGSKYINKEIKNALKGVKQIKTLIEQTNEERKSLLSNLEEAKKKKEDALNDTKDSETKLKASQGVCNDTMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWMNGDRIDSLLENDRQQTHALDVMQDSFNRASSIMDELFQDRFFTREPQDTYHYSPFSLFQRRP-FFNPKFRIARNIIPFPRFQPLNFHDMFQPFFDMIHQAQQAMDVNLHRIPYHFP-EE--DNRTVCKEIRHNSTGCLKMKDQCEKCQEILSVDCSSNNPAQVQLRQELSNSLQIAEKFTKLYDELLQSYQEKMFNTSSLLKQLNEQFSWVSQLANLTQSEDPFYLQVTTVGSSDSNVPVGFTKVVVKLFDSDPITVMIPEAVSRNNPKFMETVAEKALQEYRQKHREE >NP_999136.1 clusterin precursor [Sus scrofa] KTLLLLVGLLLTWENGPLGDKAISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTLIEQSNEERKSLLSSLEEAKKKKEDALNDTRDTETKLKGSQGLCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDIMEDSFNRASNIMDELFQDRFFNREPFDTQFFSPFGSSHRGSLFFNPKSRFARNIMPFPLFTDLNYHDMFQPFFDMIHQAQQAMDAHLHRIPYHFPEEN-SNDRAVCKEIRHNSTGCLRMKDQCEKCREILSVDCSASNSSQMQLRQELYTSLQMAEKFSKLYDQLLQSYQQKMLNTSSLLKQLNEQFSWVSQLANLTQNDDRYYLQVTTVNSSDPSVPSGLTKVVVKLFDSYPITLIIPQEVS--DPKFMETVAEEALQQYRQRSREE >XP_038948927.1 clusterin isoform X2 [Rattus norvegicus] KILLLCVALLLTWDNGMLGEQEFSDNELQELSTQGSRYVNKEIQNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKKEGALDDTRDSEMKLKAFPEVCNETMMALWEECKPCLKHTCMKFYARVCRSGSGLVGRQLEEFLNQSSPFYFWMNGDRIDSLLESDRQQSQVLDAMQDSFTRASGIIDTLFQDRFFTHEPQDIHHFSPMGFPHKRPHFLYPKSRLVRSLMPLSHYGPLSFHNMFQPFFDMIHQAQQAMDVQLHSPALQFPDKEGEDDRTVCKEIRHNSTGCLKMKGQCEKCQEILSVDCSTNNPAQANLRQELNDSLQVAERLTQQYNELLHSLQSKMLNTSSLLEQLNDQFSWVSQLANLTQGDDQ-YLRVSTVTTSDSEVPSRVTEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSR-- >NP_038520.2 clusterin preproprotein [Mus musculus] KILLLCVALLLIWDNGMLGEQEVSDNELQELSTQGSRYINKEIQNAVQGVKHIKTLIEKTNAERKSLLNSLEEAKKKKEDALEDTRDSEMKLKAFPEVCNETMMALWEECKPCLKHTCMKFYARVCRSGSGLVGQQLEEFLNQSSPFYFWMNGDRIDSLLESDRQQSQVLDAMQDSFARASGIIDTLFQDRFFARELHDPHYFSPIGFPHKRPHFLYPKSRLVRSLMSPSHYGPPSFHNMFQPFFEMIHQAQQAMDVQLHSPAFQFPDREGEDDRTVCKEIRRNSTGCLKMKGQCEKCQEILSVDCSTNNPAQANLRQELNDSLQVAERLTEQYKELLQSFQSKMLNTSSLLEQLNDQFNWVSQLANLTQGEDKYYLRVSTVTTSDSEVPSRVTEVVVKLFDSDPITVVLPEEVSKDNPKFMDTVAEKALQEYRRKSRAE >XP_017907364.1 PREDICTED: clusterin [Capra hircus] KTLLLLVGLLLSWESGR----AISDKELQEMSAEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARSVMPFPLLEPLNFHDVFQPFYDMIRQAQQAMDAHLQRTPYHFPVEN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLDTSALLKQLNEQFTWVSQLANLTQSDDQYYLQVFTVNSSDPSIPSGLTKVVVKLFNSLPITVTVPQEVS--NPNFMENVAEKALQQYRRKSHEE >KAF4025298.1 hypothetical protein G4228_017406 [Cervus hanglu yarkandensis] KTLLLLVGLLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKSLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSSDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPRFMENVAEKALQQYRRKSL-- >XP_004004480.1 clusterin [Ovis aries] KTLLLLVGLLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPLNFHDVFQPFYDMIRQAQQAMDAHLQRTPYHFPVEN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASSPTQTLLRQQLNTSLQLAEKFSRLYDQLLQSYQQKMLDTSTLLKQLNEQFTWVSQLANLTQSDDQYYLQVFTVNSSDPSIPSGLTKVVVKLFNSFPITVTVPQEVS--SPNFMENVAEKALQQYRRKSHEE >XP_043343022.1 clusterin [Cervus canadensis] KTLLLLVGLLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKSLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSSDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFMEDVAEKALQQYRRKSLEE >XP_043747136.1 clusterin [Cervus elaphus] KTLLLLVGLLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSSDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFMEDVAEKALQQYRRKSLEE >KAB0368575.1 hypothetical protein FD755_019609 [Muntiacus reevesi] KTLLLLVALLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDE-----FFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANVTQGDDQYYLQVSTVNSSDPSIPSGLTKVVVKLFNSFPITVMVPQEVS--SPHFMENVAEKALQQYRRKSLEE >NP_776327.1 clusterin preproprotein [Bos taurus] KTLLLLMGLLLSWESGW----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMTALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDREQSHVMDVMEDSFTRASSIMDELFQDRFFLRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPFNFHDVFQPFYDMIHQAQQAMDAHLQRTPYHFPTEN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSASNPTQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQSDDQHYLQVFTVNSSDPSIPSGLTKVIVKLFNSFPITVTVPQEVS--SPNFMENVAEKALQQYRRKSQEE >XP_020733543.1 clusterin isoform X2 [Odocoileus virginianus texanus] KTLLLLVGLLLSWESGR----AISDKELQEMSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMLALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDELFQDRFFPRRPQDTHYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNTSLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANLTQGDDQYYLQVSTVNSSDPSVPSGLTKVVLKLFNFFPITVMVPQEVS--SPHFMENVAEKALQQYRRKSLEE >KAB0365458.1 hypothetical protein FD754_009614 [Muntiacus muntjak] ------------------------------MSTEGSKYVNKEIKNALKEVKQIKTQIEQTNEERKLLLSSLEEAKKKKEDALNDTRDSENKLKASQGVCNETMMALWEECKPCLKQTCMKFYARVCRSGSGLVGHQLEEFLNQSSPFYFWINGDRIDSLMENDRQQSHVMDVMEDSFTRASSIMDE-----FFPRRPQDTQYYSPFSSFPRGSLFFNPKSRFARNVMPFPLLEPINFHDVFQPFYDMIYQAQQAMDAHLRRSPYQFPMAN--NDRTVCKEIRHNSTGCLRMKDQCEKCQEILEVDCSTSDPSQTLLRQQLNASLQLAEKFSRLYDQLLQSYQQKMLNTSALLKQLNEQFTWVSQLANVTQGDDQYYLQVSTVNSSDPSIPSGLTKVVVKLFNSFPVTVMVPQEVS--SPHFMENVAEKALQQYRRKSLEE >XP_021135541.1 LOW QUALITY PROTEIN: clusterin [Columba livia] ------------------------------MSAAGSKYIDTEVENAINGVKQMKTLMDKTSKDHQAILHTLEETKRRKEVSTRAGMDKEQQLAAKQEVCNETMLALWEECKPCLKHTCMRFYSRTCHSGSGLVGRQLEEFLNRSSPFSIWVNGERIDSLLERDQRQERQFEDLEERFGLLEDEVDDIFQDSTQVYGRIHPFFPAPF-PPVQRVRLVPRSQRFSRELHPLFPHPHHSFHRLFQPLFEMTQRVQGG-----------WERRNFSDDRMVCREIRRNSAGCLRMRDEXEKCRDILAVAPFVRPPL----------------------------------------------------------------FQ---VLSSDPLAPPD-TQVTVQLFDSEPLSLTVPGDISWDDPRFMELVAEQALRHYKQNAIE-
PhyML tree of selected proteins (((((NP_001080775_1_clusterin_precursor__Xenopus_laevis_:0.2709292,XP_040204262_1_clusterin__Rana_temporaria_:0.25100004):0.30526672,(((NP_001003370_1_clusterin_precursor__Canis_lupus_familiaris_:0.04087718,XP_003984849_1_clusterin__Felis_catus_:0.05728344):0.03133237,(NP_999136_1_clusterin_precursor__Sus_scrofa_:0.07404271,((XP_020733543_1_clusterin_isoform_X2__Odocoileus_virginianus_texanus_:0.01397999,((KAB0368575_1_hypothetical_protein_FD755_019609__Muntiacus_reevesi_:0.00000001,KAB0365458_1_hypothetical_protein_FD754_009614__Muntiacus_muntjak_:0.00251917):0.00465082,(XP_043747136_1_clusterin__Cervus_elaphus_:0.00000001,(XP_043343022_1_clusterin__Cervus_canadensis_:0.00000001,KAF4025298_1_hypothetical_protein_G4228_017406__Cervus_hanglu_yarkandensis_:0.00463886):0.00231864):0.00230711):0.00000001):0.02746956,(NP_776327_1_clusterin_preproprotein__Bos_taurus_:0.01626613,(XP_017907364_1_PREDICTED__clusterin__Capra_hircus_:0.00934787,XP_004004480_1_clusterin__Ovis_aries_:0.00463733):0.00979761):0.01347513):0.08602979):0.07967631):0.07432798,((NP_001075518_1_clusterin_precursor__Oryctolagus_cuniculus_:0.12019135,(NP_038520_2_clusterin_preproprotein__Mus_musculus_:0.04319477,XP_038948927_1_clusterin_isoform_X2__Rattus_norvegicus_:0.02552542):0.14012531):0.02509611,(XP_003777274_1_clusterin_isoform_X2__Pongo_abelii_:0.01023572,((XP_004046872_3_clusterin_isoform_X1__Gorilla_gorilla_gorilla_:0.00460697,((sp_P10909_2_CLUS_HUMAN_Isoform_2_of_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU:0.00000001,(sp_P10909_CLUS_HUMAN_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU_PE_1_SV_1:0.00000001,sp_P10909_5_CLUS_HUMAN_Isoform_5_of_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU:0.00000001):0.00000001):0.00000001,(sp_P10909_3_CLUS_HUMAN_Isoform_3_of_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU:0,(sp_P10909_6_CLUS_HUMAN_Isoform_6_of_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU:0.00000001,sp_P10909_4_CLUS_HUMAN_Isoform_4_of_Clusterin_OS_Homo_sapiens_OX_9606_GN_CLU:0.00000001):0):0.00242468):0.00925754):0.00166586,(XP_001164647_1_clusterin_isoform_X2__Pan_troglodytes_:0.0022942,XP_034821769_1_clusterin_isoform_X2__Pan_paniscus_:0.00000001):0.00524293):0.00935293):0.10162821):0.0559625):0.67101089):0.08484731,(tr_Q5SPR2_Q5SPR2_DANRE_Clusterin_OS_Danio_rerio_OX_7955_GN_clu_PE_3_SV_1:0.36248597,(XP_030261895_1_clusterin_isoform_X1__Sparus_aurata_:0.16046953,(XP_015803151_1_PREDICTED__clusterin__Nothobranchius_furzeri_:0.12387546,XP_011490335_1_clusterin_isoform_X2__Oryzias_latipes_:0.1434792):0.03893087):0.2915068):0.46488274):0.10731237,(XP_006033945_1_clusterin__Alligator_sinensis_:0.00000001,KYO32283_1_clusterin__Alligator_mississippiensis_:0.06249449):0.1730222):0.14116216,XP_021135541_1_LOW_QUALITY_PROTEIN__clusterin__Columba_livia_:0.14940615,(XP_010706357_1_LOW_QUALITY_PROTEIN__clusterin__Meleagris_gallopavo_:0.01975462,NP_001383106_1_clusterin_precursor__Gallus_gallus_:0.01443905):0.12742314);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)