PB0193

DATABASE

Click here to access PB0193 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0193	Q99972	Myocilin	MYOC	GLC1A, GPOA, JOAG, JOAG1, TIGR	Homo_sapiens	Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork.

Domains

Gene Ontology

PF02191 (OLF)

GO:0001968 (enables) fibronectin binding GO:0005109 (enables) frizzled binding GO:0005515 (enables) protein binding GO:0030971 (enables) receptor tyrosine kinase binding GO:0032027 (enables) myosin light chain binding GO:0046872 (enables) metal ion binding GO:0001649 (involved in) osteoblast differentiation GO:0001952 (involved in) regulation of cell-matrix adhesion GO:0001953 (involved in) negative regulation of cell-matrix adhesion GO:0007165 (involved in) signal transduction GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling GO:0014734 (involved in) skeletal muscle hypertrophy GO:0022011 (involved in) myelination in peripheral nervous system GO:0030335 (involved in) positive regulation of cell migration GO:0031175 (involved in) neuron projection development GO:0035024 (involved in) negative regulation of Rho protein signal transduction GO:0038031 (involved in) non-canonical Wnt signaling pathway via JNK cascade GO:0038133 (involved in) ERBB2-ERBB3 signaling pathway GO:0043408 (involved in) regulation of MAPK cascade GO:0045162 (involved in) clustering of voltage-gated sodium channels GO:0051492 (involved in) regulation of stress fiber assembly GO:0051496 (involved in) positive regulation of stress fiber assembly GO:0051497 (involved in) negative regulation of stress fiber assembly GO:0051894 (involved in) positive regulation of focal adhesion assembly GO:0051897 (involved in) positive regulation of protein kinase B signaling GO:0051901 (involved in) positive regulation of mitochondrial depolarization GO:0060348 (involved in) bone development GO:1900026 (involved in) positive regulation of substrate adhesion-dependent cell spreading GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005739 (located in) mitochondrion GO:0005741 (located in) mitochondrial outer membrane GO:0005743 (located in) mitochondrial inner membrane GO:0005758 (located in) mitochondrial intermembrane space GO:0005783 (located in) endoplasmic reticulum GO:0005791 (located in) rough endoplasmic reticulum GO:0005794 (located in) Golgi apparatus GO:0005929 (located in) cilium GO:0016020 (located in) membrane GO:0031410 (located in) cytoplasmic vesicle GO:0033268 (located in) node of Ranvier GO:0042995 (located in) cell projection GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q99972|MYOC_HUMAN Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2 MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESS CPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRE LGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARL RRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGE GDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEI PGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETN IRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYN PLEKKLFAWDNLNMVTYDIKLSKM >tr|Q5F0G5|Q5F0G5_DANRE Myocilin OS=Danio rerio OX=7955 GN=myoc PE=2 SV=1 MWFLAVLWISSLLMGSQVQSSANLRRANAGNGRCQYTFMVDSPTEASCPSPGSTPEMEAL MSRLGLLEALVARLVGGEAMPESSQSSGSGLQDSYNQVMGENAQLKREKQRLDRQVQDLQ QRMEELRQEAERLRSRPCMQQTSSRVPQKDNSFRPGSGHVPSNLASRPGNPQEDKSSLRD PAWQYSNPGYQELTAVVTEVTAPNQDGPADISGCGDLVWVENPEVHRKADSIAGKYGVWM QDPEAKEPYGPDMVWRIDSVGSEVRQLFGYENMDQLTRGFPTKVLLLPESVESTGATMYK GSLYYQRRLSRTLIRYDLHAESIAARRDLPHAGFHGQFPYSWGGYTDIDLAIDENGLWAI YSTNKAKGAIVISQLDPHNLEVKGTWETKIRKTSVANAFMICGKLYTVASYTSPNTTVNY MFDTATSQGKAISVPFKNRYRYNSMVDYNSAKRKLYAWDNYYMVSYSVRLGKQE
Selected proteins from model organisms >sp|Q99972|MYOC_HUMAN Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2 MRFFCARCCSFGPEMPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESS CPEQSQAMSVIHNLQRDSSTQRLDLEATKARLSSLESLLHQLTLDQAARPQETQEGLQRE LGTLRRERDQLETQTRELETAYSNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARL RRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPASRILKESPSGYLRSGE GDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFE YDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEI PGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETN IRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYN PLEKKLFAWDNLNMVTYDIKLSKM >tr|Q5F0G5|Q5F0G5_DANRE Myocilin OS=Danio rerio OX=7955 GN=myoc PE=2 SV=1 MWFLAVLWISSLLMGSQVQSSANLRRANAGNGRCQYTFMVDSPTEASCPSPGSTPEMEAL MSRLGLLEALVARLVGGEAMPESSQSSGSGLQDSYNQVMGENAQLKREKQRLDRQVQDLQ QRMEELRQEAERLRSRPCMQQTSSRVPQKDNSFRPGSGHVPSNLASRPGNPQEDKSSLRD PAWQYSNPGYQELTAVVTEVTAPNQDGPADISGCGDLVWVENPEVHRKADSIAGKYGVWM QDPEAKEPYGPDMVWRIDSVGSEVRQLFGYENMDQLTRGFPTKVLLLPESVESTGATMYK GSLYYQRRLSRTLIRYDLHAESIAARRDLPHAGFHGQFPYSWGGYTDIDLAIDENGLWAI YSTNKAKGAIVISQLDPHNLEVKGTWETKIRKTSVANAFMICGKLYTVASYTSPNTTVNY MFDTATSQGKAISVPFKNRYRYNSMVDYNSAKRKLYAWDNYYMVSYSVRLGKQE >NP_034995.3 myocilin precursor [Mus musculus] MPALHLLFLACLVWGMGARTAQFRKANDRSGRCQYTFTVASPNESSCPREDQAMSAIQDLQRDSSIQHAD LESTKARVRSLESLLHQMTLGRVTGTQEAQEGLQGQLGALRRERDQLETQTRDLEAAYNNLLRDKSALEE EKRQLEQENEDLARRLESSSEEVTRLRRGQCPSTQYPSQDMLPGSREVSQWNLDTLAFQELKSELTEVPA SQILKENPSGRPRSKEGDKGCGALVWVGEPVTLRTAETIAGKYGVWMRDPKPTHPYTQESTWRIDTVGTE IRQVFEYSQISQFEQGYPSKVHVLPRALESTGAVVYAGSLYFQGAESRTVVRYELDTETVKAEKEIPGAG YHGHFPYAWGGYTDIDLAVDESGLWVIYSTEEAKGAIVLSKLNPANLELERTWETNIRKQSVANAFVICG ILYTVSSYSSAHATVNFAYDTKTGTSKTLTIPFTNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLLEM >KAB0377578.1 hypothetical protein FD755_012022 [Muntiacus reevesi] MPAVQLLLLACLVGGVGARTAQFQKANDQSGRCQYTFRVASPTESSCPVQDQAMSAIQELQRDSSDQRATLEATKARLSS LEAVLHRLTSGQPTGPLETQQGLQRELEALRREREQLETQTRELESAFSNLIRDKSALEEEKRRLQAENEDLARRLESSS QEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENVDFQELKSELTEVPASQILKESLSGHPRNEEEGTGCGELVWVGEP VTLRRAETITGKYGVWMRDPQAADPYTAETTWRIDTVGTDIRQVFEYDLRRQFAQGYPSKVHVLPRPVESTGAVVYRGSL YFQAAESRTLLRYDLRAETLRAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELE QTWETNIRKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNM VTYDIKLSRV >KAB0345677.1 hypothetical protein FD754_022603 [Muntiacus muntjak] MPAVQLLLLACLVGGVGARTAQFQKANDQSGRCQYTFRVASPTESSCPVQDQAMSAIQELQRDSSDQRATLEATKARLSS LEAVLHRLTSGQPAGPLETQQGLQRELEALRREREQLETQTRELESAFSNLIRDKSALEEEKRRLQAENEDLARRLESSS QEVASLRRGQCPQAHSSSQDVPSGSREGKDSGFNLESETTQQTKSGMLHIRITDEREATMRQRCGELVWVGEPVTLRRAE TITGKYGVWMRDPQAADPYTAETTWRIDTVGTDIRQVFEYDLRRQFAQGYPSKVHVLPRPVESTGAVVYRGSLYFQAAES RTLLRYDLRAETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNI RKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKL SRV >XP_043341789.1 myocilin [Cervus canadensis] MPAVQLLLLACLVGGVGARTAKFQKANDQSGRCQYTFRVASPSESSCPEQDQAMSAIQELQRDSSDQRATLEATKARLSS LEAILHRLTSGQPTGPLETQQGLQKELEALRREREQLETQTRELESAFSNLVRDKSALEEEKRRLQAENKDLARRLESSS QVVASLRRGQCPQAHSSSQDVPSGSREVAKWNLEKVDFQELKSELTEVPASQILKESLSGHPRNEEEGTGCGELVWVGEP VTLRTAETITGKYGVWMRDPEAAYPYTRETTWRIDTVGTDIRQVFEYDLSRQFAQGYPSKVHVLPRPLESTGAVVYRGSL YFQAAESRTLLRYDLRAETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELE QTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNM VTYDIKLSRM >OCT82906.1 hypothetical protein XELAEV_18025441mg [Xenopus laevis] MGSLALHIVVTLWVAQGISGQFSRSSDLNGQCTYSFTVPSATEASCTEPGQAKSVIQELQLELSVRHKDMETLNTRLGLL EKIVNRFLGGEGPLKPSTGPQAGADLQVEVQKLRMEKDEWEGQRASLEMAYADLLKEKDSLQEEKLQLNQRLETVLQGQC PQVSDPSRTQVPDPSRTQVPDPSRTRVPDTFKAKDQQAPSRQVSRWGADPVGYQELKSELTALPASQMIPETHLANHSSE TTRAEGTCGELTWIGEPTTYRKADNIAGKYGVWMRDPKPLAPYTMDTVWRVNTVGADIRQVFEYENIDQLIKGYPGKVYV LPRSMESNGAVIYKGSLYYPRRKSRILVKYDFKTESVAVQKELPNAGYHGQYPYSWGGYTDIDLAVDEVGLWAIYSTEKA KGSIVLSLLDSESLEVKQSWESQIRKQSVANAFMICGTLYTVGSYSSSSTTVNFAFDTSTGAQRPVGIPFKNQYGYASMI DYNPTEKKIYGWDNFNMVSYDVRLSKM >OWK08457.1 MYOC [Cervus elaphus hippelaphus] MTGRVSPKMPAVQLLLLACLVGGVGARTAKFQKANDQSGRCQYTFRVASPSESSCPEQDQAMSAIQELQRDSSDQRATLE ATKARLSSLEAILHRLTSGQPTGPLETQQGLQKELEALRREREQLETQTRELESAFSNLVRDKSALEEEKRRLQAENKDL ARRLESSSQVVASLRRGQCPQAHSSSQDLPSGSREGCGELVWVGEPVTLRTAETITGKYGVWMRDPEAAYPYTRETTWRI DTVGTDLRQVFEYDLSRQFAQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTLLRYDLRAETLKAEKEIPGAGYHGQ FPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDAT VNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRIYCFHFGTEEESKERRRKGH >NP_110492.2 myocilin precursor [Rattus norvegicus] MPSCAYCCSCGPKMPALQLLFLACLVWGMGARTAQFRKANDRSGRCQYTFTVASPSESSCPREDQAMSAI QDLQRDSSIQHADLESTKARVRSLESLLHQMTSGGVTGTQEVQEGLQGQLGALRRERDQLETQTRDLEVA YNNLLRDKSALEEEKRQLEQENKDLARRLEGSSQEVARLRRGQCPSTHHPSQDMLPGSREVSQWNLDTLA FQELKSELTEVPASQILKNQSGHPRSKEGDKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTHPYTQ ETTWRIDTVGTGIRQVFEYSQISQFEQGYPSKVHVLPQALESTGAVVYAGSLYFQGAESRTVLRYELNTE TVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYSTEENRGAIVLSKLNPENLELESTWETNIR KQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGISKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNF NMVTYDIKLSEM >NP_776543.2 myocilin precursor [Bos taurus] MPAVQLLLLACLLGGVGARTAQFQKANDRSGRCQYTFSVASPSESSCPEQGQAMLAIQELQRDSSEQRAT LESTKARLSSLEALLHRLTSGQPAGPLETHQGLQRELEALRREREQLETQTQELESAYSNLVRDKSALEE EKRRLQAENEDLARRLESSSQEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENMDFQELKSELTEVPA SQILKESPSGHPRNEEGGTGCGELVWVGEPITLRTAETITGKYGVWMRDPQATFPYTGETTWRIDTVGTD IRQVFEYDHIRQFTQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTETLKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSRL >NP_999151.1 myocilin precursor [Sus scrofa] MPAVQLLLLACLVWSAGARTAQLWKANDRSGQCQYTFKVASPNESSCPEQGQTMSALQDLQRDSSEQRAA LESTKARLSSLEALLHRLILGQATGPWEAQEGLEKELGTLRREREQLETQNRELETTYNNLTRDKSALEE EKRQLETENEDLARRLESSSQELAKLKVQCPQAHSMSQDVPLGSREVSKWNVENLDFQELKSELTEVPAA RILKESVSGHSGSEEGGSGCGELVWVGEPVTLRTAETITGKYGVWMRDPKATYPYTQETTWRIDTVGTDI RQVFEYDRISQFAQGYPSKVHVLPRRLESTGAVVYQGSLYFQGASSRTVIRYELSTETLKAEKEIPGAGY HGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPENLELERTWETNIRKQSVANAFIICGT LYTVSSYSSPEATINFAYDTSTGSSKALTIPFKNRYEYSSMIDYNPLEKKLFAWDNFNMVTYDIRLSRM >XP_015145920.3 myocilin [Gallus gallus] MPGAWLSLLLAGGLALSARGDPAALLRRDNDASGRCTYSFTVASPGEVSCPEAGSVAQLREELAALAARL SRLEGAGGVGGSGPRGADVSGAWSRGPQRAAPGGCEELQRAKERLEEEKGRLEREKEELGRRLESSAQEI TRLRAARCPSGTGGVPGRDALRSASKATRWEPEPLGYQELKSERTELPASRLLEETALGRPRAEDSGCGE LAWVGEPVVLGRADTIAGKYGVWMKDPEPVAPFTRETTWRVDTVGTEVRQLFQYEAAEQLARGYPAKVHV LPRPLESTGAVVYRGGLFFQPRRSRALARYDLRAEAISAERELPGAGYHGQYPYSWGGYTDIDLAVDETG LWVVYSTEKAKGAIVLSKLDPETLEIRRTWETNIRKQSVANSFIICGTLYTVSSYSAPNATVNFAYDTAT STSRSLSIPFENRFRYLSMVDYNPAERRLFAWDSYNMVAYPVRLAHA >XP_513995.2 myocilin [Pan troglodytes] MPAVQLLLLACLVWDVGARTARLRKANDQSGRCHYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLD LEATKARLSSLESLLHQLTLDQAARPQETQEGLQKELGTLRRERDQLETQIRELETAYSNLLRDKSVLEE EKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPV SRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTD VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM >NP_001041495.2 myocilin precursor [Canis lupus familiaris] MPTAQLLLLACLLWGLEARTAQLRKANDRSGRCQYIFSVASPNESSCPEQGQAMSAIQDLQRDLESTKAR LSSLEGLLHQLTLGQAAGPSESQEGLHRELGTLRKEREQLETQARELEVAYSNLLRDKSALEEEKRRLGE ENEDLAQRLEHSSQEVARLRRGQCPQAHSSSQDVPAGSREVSKWNVETVNFQELKSELTEVPASRILKES PSGHPRNEEGDSGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPHTRETTWRIDTVGTDIRQVFEY ELASQFLQGYPSKVHVLPRPLESTGAVVYRGSLYFQGAGSGTVVRYELTAETVKAEREIPGAGYHGQFPY SWGGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFVICGHLYTISS YSSPDATVNFAYDTGTGRSRVLSIPFKNRYKYSSMIDYNPLEKKLFAWDNFNMVTYDIRLSKM >NP_001075619.1 myocilin precursor [Oryctolagus cuniculus] MPAVQLLLLAGLVWGAGARTAQLRKANDRSGRCQYTFSVASPSESSCPEQGQTMSAIQDLQRDSSTQRAD LESTKARLSSLESLLHRLTLAQTSGPQEIQEELQKELGTLRRERDQLESQTRELEAAYSNLLRDKSALEE EKRRLMQENEDLARRLESSSQEVARLARGQCPQARDTSQDVPAGSREASQWNLDTLAFQELKSELTEVPA SRILKENPPVLPRGEEGDNGCGELVWVGQPVTLRTAETITGKYGVWMRDPKPTSPHTQETTWRIDTVGTD IRQVFEYDRISQFVQGYPSKVYVLPRSLESTGAVVYAGSLYFQGAGSRTVIRFELNTETVKAEKEIPGAG YRGQFPYSWGGYTDIDLAVDETGLWVIYSTEEARGAIVLSKLNPENLELEKTWETNIRKQSVANAFIICG TLYTVSSYSSADATVNFAYDTGTGISKPLAIPFKNRYKYSSMIDYNPLERKLFAWDSFNMVTYDIKLSKI >XP_002809846.1 myocilin [Pongo abelii] MPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVVSPNESSCPEQSQAMSVIRNLQRDSSTQRLD LEATKARLSSLESLLHQLTLDQAARPQDTQEGLQRELGTLRRERDQLETQTRELETAYNNLLRDKSVLEE EKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSKLTEVPA SRILKESPSGYLRSREGDNGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTD VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPDNLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSADATINFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKI >XP_003824704.1 myocilin [Pan paniscus] MPAVQLLLLACLVWDVGARTARLRKANDQSGRCHYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLD LEATKARLSSLESLLHQLTLDQAARPQETQEGLQKELGTLRRERDQLETQIRELETAYSNLLRDKSVLEE EKKRLSQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPV SRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTD VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSADATVNFAYDTGTGISKTLTIPFKNHYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM >NP_001265779.1 myocilin precursor [Felis catus] MPATQLLLLACLVWGLGARTAQLRKANDRSGRCQYTFSVASPNESSCPEQGQAMSAIQDLQRDSSAQRAD LESTKARLRSLESLVHQLTLDEAAGPSATQEGLQRELGALRREREQLESQNRELEASYSNLLRDKSALEE EKRRLREENEDLARRLDSSSQEVARLRRGQCPQARGTPQDVPSGSREVSKWNVETVNFQELKSELTEVPA SRILKESPSGHPRSEEGDPGCGELVWVGEPLTLRRAETITGKYGVWMRDPKPAYPYTQETTWRIDTVGTD IRQVFEYDLSSQFLQGYPSKVHVLPRPLESTGAVVYWGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKLNPESLELERTWETNIRKQSVANAFIICG RLYTVSSYSAPDATINFAYDTGTGRSRALTVPFKNRYKYSSMVDYNPLEKKLFAWDNFNMVTYDLRLSEM >XP_004013742.4 myocilin isoform X1 [Ovis aries] MPAVQLLLLACLVGGVGARTAQFQKANDRSGRCQYTFSVASPSESSCPEQGQAMSAIQELQRESSEQRAT LESTKARLSSLEALLHRLTSGQPAGPLETQQGLQSELEALRREREQLETQTRELESAYSNLVRDKSALEE EKRQLQAENEDLARRLESSSQEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENVDFQELKSELTEVPA SQILKESPSGHPRNEEGGTGCGELVWVGEPITLRTAETITGKYGVWMRDPQAAFPYTQETTWRIDTVGTD IRQVFEYDLIRQFTQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTEALKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSRM >XP_004027946.2 myocilin [Gorilla gorilla gorilla] MPAVQLLLLACLVWDVGARTAQLRKANDQSGRCQYTFSVASPNESSCPEQSQAMSVIHNLQRDSSTQRLD LEATKARLSSVESLLHQLTLDQAARPQETQEGLQRELGTLRQERDQLETQTRELETAYSNLLRDKSVLEE EKKRLRQENENLARRLESSSQEVARLRRGQCPQTRDTARAVPPGSREVSTWNLDTLAFQELKSELTEVPA SRILKESPSGYLRSGEGDTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTD VRQVFEYDLISQFMQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICG TLYTISSYSSADATVNFAYDTGTGISKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM >XP_023809784.1 myocilin [Oryzias latipes] MFLLLLLAGLLLQGDAQDQASLWRGNDRSGRCVYSFTVPSPVEASCPQPAAPEVEALKVRLGVLEMLVSQ LSGKSLQPPGGRQGAGDRAQAELQDALNRAVAERSLLQGEKERLKREMKALQLRMEEMRRETERLRKRPC PQTPAAPPSHPQRDRAPTRPLEDSAWQYGSPAFQELKAEVTEVPVPDSKQNQTGCGDLLSVGEPVSHRRA DNIAGKYGVWMQDPEPVSPYGPNMVWRIDTVGTEVRQLFGYEDLEQLSKGFPSKVLLLLDPLESTGATLY RGSLYYQRRLSRTLIRYELAAEHVAARRELPHAGFHGQFPYSWGGYTDIDLAVDEKGLWAVYSTSKAQGA IVISLLDPLSLEVRRSWETNIRKSSVANSFIICGKMYTVASYSAPDSTINYVYDTETSQGKAVSIPFKNK YRYNSMIDYSLAQRKLFAWDNFHLVSYDIRMSHSPAT >XP_013223602.1 myocilin [Columba livia] MVRTAGREEMPGGRCRERPGHPNRVTPPGPGRTETSARRSSAGPRSLQPSGPGGAGERRKDEAALGDELG RRLESSAQEIARLRASRCHPGGGGPHRDTLRAPGKAPRWDPQPLAYQELQSERTEVPASRLLEETGLGRP GSEDLGTATGCGELVWVGEPVVFGRADSIAGKYGVWMKDPEPVPPFTRDTTWRVDTVGTEVRQLFQYEAA EQLAQGYPTKVHILPQPLESTGAVVYRGGLFFQPRRSRAVARYDLRGETVTAEREIPGAGYHGQYPYSWG GYTDIDLAVDETGLWVIYSTEKARGAIVLSKLDPETLEIRRTWETKIRKRGVANSFVICGTLYTVSSYSA PNATINFAYDTATSTSRALSIPFENRFRYLSMVDYNPTERQLFAWDSFNMVTYPIRLSQA >XP_005690701.2 PREDICTED: myocilin isoform X1 [Capra hircus] MPAVQLLLLACLVGGVGARTAKFQKANDRSGRCQYTFSVASPSESSCPEQGQAMSAIQELQRESSEQRAT LESTKARLSSLEALLHRLTSGQPAAPLETQQGLQTELEALRREREQLETQTRELESAYSNLVRDKSALEE EKRQLQAENEDLARRLESSSQEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENVDFQELKSELTEVPA SQILKESPSGHPRNEEGGTGCGELVWVGEPITLRTAETITGKYGVWMRDPQAAFPYTPETTWRIDTVGTA IRQVFEYDLIRQFTQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTETLKAEKEIPGAG YHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSPM >XP_006017807.1 myocilin isoform X1 [Alligator sinensis] MLVACLLLSLSLLQGALGSTVHLRRANDRHGRCTYSFTVPSPHEASCPGSDQAMPAILDLQRESNMQRSE LESAKARLSLLESLVTQSHAMEDSSASTVESLQRQLASLRMETTQQKSQASRMETAYRDLLRNKSSLEEE KRHLEREKEELERRLENSSQEITQLRANQCPQVRDTPVPDSLQRSKKVSRWDMESPDYQELKSEMTEVSA SSLFQERSSHSRLGAEDTGTAGCGELVWVGEPVTLRKAETIVGKYGVWMKDPEPASPYTRETTWRIDTVG TDIRQVFEYDSADQFMQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLRKETITVQKDLTN AGYHGQFPYSWGGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTLDPETLEIRQTWETNIRKQSVANSFMI CGTLYTISSYSSPDAMIHFAYNTATSTRKLLKIHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLS KM >XP_014460702.1 PREDICTED: myocilin isoform X1 [Alligator mississippiensis] MLVACLLLSLSLLQGALGSTVHLRRANDRHGRCTYSFTVPSPHEASCPGSDQAMPAILDLQRESNMQRSE LESAKARLSLLESLVTQSHAMEGSSASTVESLQRQLASLRMETTQQKSQASRMETAYRDLLRNKSSLEEE KRHLEREKEELERRLENSSQEIAQLRANQCPQVSDTPVPDSLQRSKKVSRWDMESPDYQELKSEMTEVSA SSLFQEHSSHSRLGAEDTGTAGCGELVWVGEPVTLRKAETIAGKYGVWMKDPEPASPYTRETTWRIDTVG TDIRQVFEYDSTDQFIQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLRKETITVQKDLTN AGYHGQFPYSWGGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTLDPETLEIRQTWETNIRKQSVANSFMI CGTLYTISSYSSPDAMIHFAYNTATSTRKLLKIHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLS KM >XP_015832476.1 PREDICTED: myocilin [Nothobranchius furzeri] MFFLLSLCIFGLLLRGDAQERASLWRGNDRSGQCQYTFTVPSPAEASCPQASAPEVEGLKARLSILEALV SQLSGKDTQSPGGQRGASVRGHSELQETLNRAVGERNLLQGEKERLEMELEGLRLRMEEMRRETERLRNR PCLPQNPVVPPSFPQRDRSPVRPAVGSNQMSHLMTRPNRQGDSSSLRDSAWQYGSQGFQELKADVTEVPA PDSHQDNTGCGTLVSVGDPVTHRKADSIAGKYGVWMQDPEAVSPYGPSMVWRIDTIGTDVRQLFGYDDME QLSKGFPSKVLLLPDPLESTGATLYRGSLYYQRRLSRSLIRYDLAAEHVAARRELPHAGFHGQFPYSWGG YTDIDLSVDEKGLWAVYSTNKAQGAIVISQLDPQTLEVKKSWETNIRKASVANSFIICGKMYTVASYAAH NTVINYMFDTETSQGRAVSIPFKNRYGYNSMVDYSMAQRKLFAWDNFHLVTYDISLGRQQVN >XP_020727692.1 myocilin [Odocoileus virginianus texanus] MPAVQLLLLACLVGGVGARTAQFQKANDQSGRCQYTFRVASPSESSCPEQDQAMSAIQELQRDSRDQRAT LEATKARLSSLEAVLHRLTSGQPTGPLEAQQGLQKELEALRREREQLETQTRELESAFSNLVRDKSALEE EKRQLQAENEDLARRLESSSQEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENVDFQELKSELTEVPA SQILKEGLSGHPRSEEEGTGCGELVWVGEPVTLRTAETITGKYGVWMRDPQAAYPYTRETTWRIDTVGTD IRQVFEYDLSGQFAQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAKSRTLLRYDLRTETLQAEKEIPGAG YHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICG TLYTVSSYSSPDATVNFAYDTGTGSSKALTIPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRM >XP_030289193.1 myocilin [Sparus aurata] MFLLLSLCVSGLLLNADAQERASLWRGNDRAGRCQYTFSVPSPVESSCPQTGGPEMEGLKARLGMLEVLV ARLTGGETVAPQRAGARAQTELQEALNRATGERNLLQGEKERLERELMGLQGRMEEMRKETERLRNRPCP PLIPVVQPSPSLQGGGLMRPAGGSSAMSHLMTRPNRQGDSSSLRDSAWQYRSPGFQELKAEVTEVPAPDG SEENTGCGELVSVGEPVTHRKADNIEGKYGVWMQDPEAASIYGPNMIWRIDTIGSDVRKLFGYDDMEQLA KGFPSKVLLLPEQVESTGATVYRGSLYFQRRLSRTLIRYDLASESVAARRELPHAGFHGQFPYSWGGYTD IDLAVDEQGLWAVYSTSKAKGAIVISKLDPGSLEVKKSWETNIRKSSVANSFIICGKLYTVASYTAPDTI INYMYDTETSQGKAVSIPFRNKHRYNSMIDYNRAQRKLFAWDNYHMVSYDIKLGRQQAN >XP_040216066.1 myocilin [Rana temporaria] MGFFTLNILVPLVFCLAQGSPQLRRANDRQGQCTYTFTVPSPSEGSCTEPGEAMTSIRELQLENAARTQE TAGLQTRVSLLENMVNKFLGGKDLQQATSSPQSWSDNQKEMETLRMQKDEWEGQRVSLEMAYSDLLKEKT SLEEDKQRLTERLERVQGQCPPVTEVSRNRDQRVSPRQGPSPAEIHGTGGRTSPVAARDGTADLSRWGAD GMGYQELKSELTALPASRMIPENRSAVESLQNIKMGGSCGEITWVGEPTTYRKADNIAGKYGVWMRDPEP VSPFNEETIWRINTVGADIRQVFEYENLDQLVKGYPTKVYVVPRSMESNGAVIYKSSLYYVRRKSRIIVK YDFKTETVAIQKELSDAGYHGQHPYSWGGYTDIDLAVDELGMWAIYSTDKTKGSIVISQLNPKTLEVNQS WETTIRKHSVANAFMACGTLYTVGSYSSTNTTINFAYDTHTGVQKQISVPFKNQYGYGSMVDYNPREKKI YGWDNYNMVSYDVRLSKM >XP_039269227.1 myocilin-like [Styela clava] MLLRYSSKSVAILLMTMQTLAISKSEDIVGDDDSSNIVDELDRPLSFNQNFKTTAPQGPSTTALTDNVHNGDPVTTLLMS PDQYGQVASSEVIHQPARPGVGPNRPLMGQQSRRNSNIFYTTGQQSSNARQSGRTCQYIFTVENADHCTHTTTEIAVNHV ARTTLPMQQSKNILDEYSERLRKLERTVYGETAGQQSENIQRDSSMITEVVAHNMEMPGQTTSPDESTQTKPISLVEIAQ QMIKQLATLEKGIVRSEKEREDLRKQNKNLIFTLRRSSAARKNLASSKSELEKNLLKEKDKYMQLCNSNRSLSLQNEALR SHKAKLETVQESFRKRIHVLETEKEQLSRTATHWQRKHSELEIANDVLKMRVHNFSGTLENCNKLTAKGELLQQQIELEQ EKNKILVVNNSQLMKQLENATSRIKLLQEEIARDTIFSSGGQDLPVYTSGVRRMNDQDYSYCGRITSISMPETVRGPQSY SNRIFEKYGVWMTDPLEAMGKGIVWSIDTTKERAKVLKQYESLQMYILNRPQQIIALTIPVESTGGVVYNGSFYYQRRNS RKLVRYDLRTRRVMRERPVHHAGFHGMFAYQWGGFTDIDLAVDEFGLWVIYSTRQNDGNIVVSRLNPVSLRSLMTMKTSI PKRTVANAFMACGILYTVDSYDAANASLNYEFDTFRKKLKRISIPFANQHRYNVMIDYNPQTREIYSWDNSHQVKYYVTL DKTMGKISQLTQRNGRIHRG >XP_011677256.1 amassin 4 isoform X1 [Strongylocentrotus purpuratus] MAFSRIMISPAALAMLFIVAFRCMSNANAQCNEYAHVNSSVTENGDCVCGVTSSLSSSCGSGVSSAEFQQMIRDLDQQVC TIVDINVELITLRVTFNQQGEDIIAMHEQMDNINAIKERIIDNKIVISSPEYDVIRMDLQDMETLISYLEDQNADQFIIV KLREEIANISYNLDSLEVNNDGDIESLLRDIADLQQQIAECEADNDPDSEIGFPYPWENFETKDSCGTIRGLSEPYTLRG NLASTGVWFMDPIVDVDRPWYQVGVTTASSILRYLSIEQFQTEGIHETYLPGYTLEGCSVVAYNGALFYNMYGSATIIRY DYREGSVTNQRALPNAGYKTNYVYLSGGYTSMDFAVDEQGLWVIYGKSTNSGLMSVSKIDPLTLEVEETYNTNTLKANFG ECFMVCGKLYCTDSFNKHDGRIVMMYDTTTQTSTTLNVPFDSKYLATRALKYNPRDQRLYAFNNGHALVYEIEFQVDE >XP_038073533.1 collagen alpha-1(I) chain-like [Patiria miniata] MTTCALLKMAGDKTNVCAHALHVKILYFGLALLFVFSATCFGVTYVFVASLSAELGQKCSCPDGEILLDITVLPPSGSTG DSPRGPRQAAAARHGSDNQQVRAELGLKTANIVADKPGTADLRGLNRVRRGFTHGDQESSSPRATSIEAYARLPITISLD SITAFCNKTTSRCPPGPQGPAGKEGGLGIQGPPGNQGDEGPVGAPGRPGEDGKNCNCSTDDFAVLLEKTAELAGNIGQPG PKGDTGQPGPKGESGDPGIPGPQGLSGEAGPKGVKGDTGYRGPMGQTGGQGTIGPVGEKGAPGDRGLQGFDGPQGRRGEP GRKGEVGEPGPTGPPGLTGPKGDPGSPGDHGRHGKHGEKGDRGLRGEKGVSGFPGSIGLRGSRGDIGLPGVQGPQGEAGR DGSNCSCIDPDGDMMTKFLIPTSAVEKQQLTGPPGPPGPEGPKGDIGDRGLQGPPGPNGTAAVKGQKGDIGETGPIGPLG SRGRRGDPGQTGARGDKGDTGREGPTGPEGAAGQKGEKGEPGVMGDTGPIRQPGTRETVSEACNVTAFLEELMELDNRTL KLIQGPPGPRGSPGPSGPEGKQGKQGPQGLKGDPGELGRAGPQGPIGPPGAKGTPGAKGLAGSFGYPGDPGEKGATGPPG PRGSTGDPGLPGPPGIDGRPGSKGEMGDKGDRGVDGLPGQTGAQGLPGADGTQGSAGQTGDKGARGKLGPAGQPGEDGAS GPKGEKGEKGDRGIASGMVELGNAGDDEKPASGKATYGPTPTAKPSKPQPSPDVDSSPNSECVLTKIGFPVDHKFGNKYW GSWMQDTAPNPPYPDKIWVTKHLVGDGIYEYKNMAALMSDSYTQYHRLTGAWAGTGHVVYNNALYFHNGGSGKIVQYDLT LETVTAQATIPEALYQRSNGHRYLYDSDYTYLDLAVDDNGLWVIYKTAENHQNLVVSQLDPENLSVIKTVVSNHPQSSAG DAFIICGRLYTTKSSKNFHSTVDFAVNLFTGEVLPDVDISYQNGHMKMTMMSYNPRKRLIYAWDKGYMVTYNVTLTEP >NP_573262.2 uncharacterized protein Dmel_CG6867 [Drosophila melanogaster] MFLAVNQSLQNTSKKKRKRRTAEDDPQEDSGEGTPPVRPLEPSASSDQLVGVGNGATCRVCKCPGRQSLTLVYIYLGALT LILASLSIVFYTHTQDVESLSQVEDNYSSKSFRVQFQAELMRSEEELRRLVNRIIEEEQELVGSTTASSTTQSRDPLKNE RKFTDNLISHTTRPTGKRMRRDIASSAPASMHADPLIEFFNPNHRKVLEEQDTEIRKRTGQKGAAPGGDEWIYLNTYCRV PEKIITGFCKGTQDYCPPAPQGPTGEVGPKGPPGNPGLPGIPGPKGNRGDVGLPGAPGVDGVGHLGPAGPRGPKGDAGAT GRAGLDGRDGVPGEPGLDGVPGRAGADGKNGLPGRDGKDGLHGKDGKDGLSITGPKGAQGPPGERGLKGIAGPRGRPGKP GTNGIPGVPGINAWKLQYPNGSSSNDLLIPPSITDIQVPDFQRTVIVEEGRSLNLSCTATGTPTPQVEWRREDGRTINVN GVEMASISGQFLRFTNITRHQMAAYTCFANNGIAPVANATYLVEVQFAPMISVYRQMIYAEYQSSATLECLVEAFPEAIR YWERAYDGKILDPSDKYGIESYPEGFKTTMRLTISNLRKDDFGYYHCVARNELNATMVNFEIAPQDPNSETPYVGNNMKV YGQRPPESECPVCDQCPDPSLYQCKDSILNNFEIQATGNLSYPGLPKRPKTCYLYAVGKPVFHKVVNEKFGSWLRDPSPD SDREKTFVTNENDPYNLFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSLKKITTQLP YAGVAAANRLYTTDYNYMDFNVDEVGLWVIYSTYNSNNTLVAKLDAETLKMQYNFNITLDHHQFGEMFIVCGNLYAIDSG TDKNTQIRYVVDLYKGKLLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRYNEQRLISDNS >NP_491804.2 Olfactomedin-like domain-containing protein [Caenorhabditis elegans] MEENLHYCNLAITLIAVLAFSHIHYRIWTLESECQSLTELNFRSKRDIPLSRGKNASDILWLTSLSSVKIGELMHKCTEI HEYCSEQDDVRGKPGPVGPVGPPGKSGPAGPQGRRGLMGIPGHPGPVGPPGNIGKDADCSSCPIRDELLMEREFKCPTIE NLECPNREAIPTTPWPSVTHQPMPGLVQQILSNYSEVEGCVKICLKNYTLDEEIEETITTPVAYIQGVTAHCRLQNVGKP VFHSHSTTYYGSWMRDAYPPTGDDARKRYVMNHFQGHELIEFRNEAEMRRDHVGKVHRLPYIFDGTNHVIFNASLFYQRA GYPIIAKYEFNSKQYSQFEIPGAAYRGDQYLYNNSMNYFDLAIDENALWVMFHYQEEAFLSVAKVDINNLTIYEAFNLTT VNHTDVANGIVVCGTIYLVESASEQSTYISTAYDFYRNTYSQPLIKWINLYKNANMISYNAYDKRIYIYDHGYMLSVPPL LHWLAK
Mafft alignment of selected proteins >sp|Q99972|MYOC_HUMAN Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2 MRF--FCARCCSFGPEMPAVQ--------------------------------------- ----------------------------LLLLACLVWDV-GA------------------ -------------RTAQLRKANDQSGR-CQY----------TFSVASPNESSC-----PE QSQAM---SVIHNLQRDSSTQ-RLDLEATK-------------------------ARLSS LESLLHQLTLDQ----------------------------------------AARPQETQ EG-----------------------------------------------------LQREL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQTREL-------ETAYSNLLRDKSVLEE---------- -----------------------EKKRLR------------------------------- ------------------------------------------------------------ ---------------------QENENLARRLESSSQEVARLRRGQCPQTRDT-------- ------------------------------------------------------------ --------------------------------------ARAVPPGSRE------------ ---------------------------------------------VSTWNLDTLAFQELK S--ELTEVPASRIL--------KESPSGYLR-----------------SGE--------- -----GDTGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPYTQETTWRIDTV GTDVRQVFEYDLISQF-MQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKL NPENLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGIS-KTLT IPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM-------------------- - >tr|Q5F0G5|Q5F0G5_DANRE Myocilin OS=Danio rerio OX=7955 GN=myoc PE=2 SV=1 ----------------MWFLA--------------------------------------- ---------------------------VLWISSLLMGSQ-VQ------------------ -------------SSANLRRANAGNGR-CQY----------TFMVDSPTEASC-----PS PGST-------------------PEMEALM-------------------------SRLGL LEALVARLVGGE----------------------------------------AMPESSQS SG---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------SGL-------QDSYNQVMGENAQLKR---------- -----------------------EKQRLD------------------------------- ------------------------------------------------------------ ---------------------RQVQDLQQRMEELRQEAERLRSRPCMQQTSSR------V P----QKDNSFRPGSGHVP-SN-------------------------------------- --------------------------------LASRPGNPQEDKSSLR------------ ---------------------------------------------DPAWQYSNPGYQELT A--VVTEVTAPN-----------------QD-----------------GPA--------- -----DISGCGDLVWVENPEVHRKADS----IAGKYGVWMQDPEAKEPYGPDMVWRIDSV GSEVRQLFGYENMDQL-TRGFPTKVLLLPESVESTGATMYKGSLYYQRRLSRTLIRYDLH A-ESIAARRDLPHAGFHGQFPYSW---GGYTDIDLAIDENGLWAIYSTNKAKGAIVISQL DPHNLEVKGTWE-TKIRKTSVANAFMICGKLYTVASYTSPNTTVNYMFDTATSQG-KAIS VPFKNRYRYNSMVDYNSAKRKLYAWDNYYMVSYSVRLGKQ---------E---------- - >NP_034995.3 myocilin precursor [Mus musculus] ----------------MPALH--------------------------------------- ----------------------------LLFLACLVWGM-GA------------------ -------------RTAQFRKANDRSGR-CQY----------TFTVASPNESSC-----PR EDQAM---SAIQDLQRDSSIQ-HADLESTK-------------------------ARVRS LESLLHQMTLGR----------------------------------------VTGTQEAQ EG-----------------------------------------------------LQGQL GAL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQTRDL-------EAAYNNLLRDKSALEE---------- -----------------------EKRQLE------------------------------- ------------------------------------------------------------ ---------------------QENEDLARRLESSSEEVTRLRRGQCPSTQYP-------- ------------------------------------------------------------ --------------------------------------SQDMLPGSRE------------ ---------------------------------------------VSQWNLDTLAFQELK S--ELTEVPASQIL--------KENPSGRPR-----------------SKE--------- -----GDKGCGALVWVGEPVTLRTAET----IAGKYGVWMRDPKPTHPYTQESTWRIDTV GTEIRQVFEYSQISQF-EQGYPSKVHVLPRALESTGAVVYAGSLYFQGAESRTVVRYELD T-ETVKAEKEIPGAGYHGHFPYAW---GGYTDIDLAVDESGLWVIYSTEEAKGAIVLSKL NPANLELERTWE-TNIRKQSVANAFVICGILYTVSSYSSAHATVNFAYDTKTGTS-KTLT IPFTNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLLEM-------------------- - >KAB0377578.1 hypothetical protein FD755_012022 [Muntiacus reevesi] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAQFQKANDQSGR-CQY----------TFRVASPTESSC-----PV QDQAM---SAIQELQRDSSDQ-RATLEATK-------------------------ARLSS LEAVLHRLTSGQ----------------------------------------PTGPLETQ QG-----------------------------------------------------LQREL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAFSNLIRDKSALEE---------- -----------------------EKRRLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLENVDFQELK S--ELTEVPASQIL--------KESLSGHPR-----------------NEE--------- -----EGTGCGELVWVGEPVTLRRAET----ITGKYGVWMRDPQAADPYTAETTWRIDTV GTDIRQVFEYDLRRQF-AQGYPSKVHVLPRPVESTGAVVYRGSLYFQAAESRTLLRYDLR A-ETLRAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRV-------------------- - >KAB0345677.1 hypothetical protein FD754_022603 [Muntiacus muntjak] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAQFQKANDQSGR-CQY----------TFRVASPTESSC-----PV QDQAM---SAIQELQRDSSDQ-RATLEATK-------------------------ARLSS LEAVLHRLTSGQ----------------------------------------PAGPLETQ QG-----------------------------------------------------LQREL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAFSNLIRDKSALEE---------- -----------------------EKRRLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ -------------------------------------------GKDSGFNLESETTQQTK S--GMLHIRITD-----------------ER-----------------EAT--------- -----MRQRCGELVWVGEPVTLRRAET----ITGKYGVWMRDPQAADPYTAETTWRIDTV GTDIRQVFEYDLRRQF-AQGYPSKVHVLPRPVESTGAVVYRGSLYFQAAESRTLLRYDLR A-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSRV-------------------- - >XP_043341789.1 myocilin [Cervus canadensis] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAKFQKANDQSGR-CQY----------TFRVASPSESSC-----PE QDQAM---SAIQELQRDSSDQ-RATLEATK-------------------------ARLSS LEAILHRLTSGQ----------------------------------------PTGPLETQ QG-----------------------------------------------------LQKEL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAFSNLVRDKSALEE---------- -----------------------EKRRLQ------------------------------- ------------------------------------------------------------ ---------------------AENKDLARRLESSSQVVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLEKVDFQELK S--ELTEVPASQIL--------KESLSGHPR-----------------NEE--------- -----EGTGCGELVWVGEPVTLRTAET----ITGKYGVWMRDPEAAYPYTRETTWRIDTV GTDIRQVFEYDLSRQF-AQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTLLRYDLR A-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRM-------------------- - >OCT82906.1 hypothetical protein XELAEV_18025441mg [Xenopus laevis] ----------------MGSLA--------------------------------------- ----------------------------LHIVVTLWV---AQG----------------- -------------ISGQFSRSSDLNGQ-CTY----------SFTVPSATEASC-----TE PGQAK---SVIQELQLELSVR-HKDMETLN-------------------------TRLGL LEKIVNRFLGGEG------------------------------------PLKPSTGPQAG AD-----------------------------------------------------LQVEV QKL--------------------------------------------------------- ------------------------------------------------------------ --RMEKD-----------EWEGQRASL-------EMAYADLLKEKDSLQE---------- -----------------------EKLQLN------------------------------- ------------------------------------------------------------ ---------------------QRLE---TVLQGQCPQVSDPSRTQVPDPSRTQ------V PDPSRTR----------VP-DT-------------------------------------- -----------------------------------FK-AKDQQAPSRQ------------ ---------------------------------------------VSRWGADPVGYQELK S--ELTALPASQMI--------PETHLANHS-----------------SETT-------- ----RAEGTCGELTWIGEPTTYRKADN----IAGKYGVWMRDPKPLAPYTMDTVWRVNTV GADIRQVFEYENIDQL-IKGYPGKVYVLPRSMESNGAVIYKGSLYYPRRKSRILVKYDFK T-ESVAVQKELPNAGYHGQYPYSW---GGYTDIDLAVDEVGLWAIYSTEKAKGSIVLSLL DSESLEVKQSWE-SQIRKQSVANAFMICGTLYTVGSYSSSSTTVNFAFDTSTGAQ-RPVG IPFKNQYGYASMIDYNPTEKKIYGWDNFNMVSYDVRLSKM-------------------- - >OWK08457.1 MYOC [Cervus elaphus hippelaphus] MT--------GRVSPKMPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAKFQKANDQSGR-CQY----------TFRVASPSESSC-----PE QDQAM---SAIQELQRDSSDQ-RATLEATK-------------------------ARLSS LEAILHRLTSGQ----------------------------------------PTGPLETQ QG-----------------------------------------------------LQKEL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAFSNLVRDKSALEE---------- -----------------------EKRRLQ------------------------------- ------------------------------------------------------------ ---------------------AENKDLARRLESSSQVVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDLPSGSRE------------ ------------------------------------------------------------ ------------------------------------------------------------ --------GCGELVWVGEPVTLRTAET----ITGKYGVWMRDPEAAYPYTRETTWRIDTV GTDLRQVFEYDLSRQF-AQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTLLRYDLR A-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRIYCFHFGTEEESKERRRKGH- - >NP_110492.2 myocilin precursor [Rattus norvegicus] MP---SCAYCCSCGPKMPALQ--------------------------------------- ----------------------------LLFLACLVWGM-GA------------------ -------------RTAQFRKANDRSGR-CQY----------TFTVASPSESSC-----PR EDQAM---SAIQDLQRDSSIQ-HADLESTK-------------------------ARVRS LESLLHQMTSGG----------------------------------------VTGTQEVQ EG-----------------------------------------------------LQGQL GAL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQTRDL-------EVAYNNLLRDKSALEE---------- -----------------------EKRQLE------------------------------- ------------------------------------------------------------ ---------------------QENKDLARRLEGSSQEVARLRRGQCPSTHHP-------- ------------------------------------------------------------ --------------------------------------SQDMLPGSRE------------ ---------------------------------------------VSQWNLDTLAFQELK S--ELTEVPASQIL--------K-NQSGHPR-----------------SKE--------- -----GDKGCGVLMWVGEPVTLRTAET----ITGKYGVWMRDPKPTHPYTQETTWRIDTV GTGIRQVFEYSQISQF-EQGYPSKVHVLPQALESTGAVVYAGSLYFQGAESRTVLRYELN T-ETVKAEKEIPGAGYHGQFPYAW---GGYTDIDLAVDESGLWVIYSTEENRGAIVLSKL NPENLELESTWE-TNIRKQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGIS-KTLT IPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSEM-------------------- - >NP_776543.2 myocilin precursor [Bos taurus] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLLGGV-GA------------------ -------------RTAQFQKANDRSGR-CQY----------TFSVASPSESSC-----PE QGQAM---LAIQELQRDSSEQ-RATLESTK-------------------------ARLSS LEALLHRLTSGQ----------------------------------------PAGPLETH QG-----------------------------------------------------LQREL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTQEL-------ESAYSNLVRDKSALEE---------- -----------------------EKRRLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLENMDFQELK S--ELTEVPASQIL--------KESPSGHPR-----------------NEE--------- -----GGTGCGELVWVGEPITLRTAET----ITGKYGVWMRDPQATFPYTGETTWRIDTV GTDIRQVFEYDHIRQF-TQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLR T-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSRL-------------------- - >NP_999151.1 myocilin precursor [Sus scrofa] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVWSA-GA------------------ -------------RTAQLWKANDRSGQ-CQY----------TFKVASPNESSC-----PE QGQTM---SALQDLQRDSSEQ-RAALESTK-------------------------ARLSS LEALLHRLILGQ----------------------------------------ATGPWEAQ EG-----------------------------------------------------LEKEL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQNREL-------ETTYNNLTRDKSALEE---------- -----------------------EKRQLE------------------------------- ------------------------------------------------------------ ---------------------TENEDLARRLESSSQELAKLKV-QCPQAHSM-------- ------------------------------------------------------------ --------------------------------------SQDVPLGSRE------------ ---------------------------------------------VSKWNVENLDFQELK S--ELTEVPAARIL--------KESVSGHSG-----------------SEE--------- -----GGSGCGELVWVGEPVTLRTAET----ITGKYGVWMRDPKATYPYTQETTWRIDTV GTDIRQVFEYDRISQF-AQGYPSKVHVLPRRLESTGAVVYQGSLYFQGASSRTVIRYELS T-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPENLELERTWE-TNIRKQSVANAFIICGTLYTVSSYSSPEATINFAYDTSTGSS-KALT IPFKNRYEYSSMIDYNPLEKKLFAWDNFNMVTYDIRLSRM-------------------- - >XP_015145920.3 myocilin [Gallus gallus] ----------------MPGAWL-------------------------------------- ---------------------------SLLLAGGLALSARGD------------------ -------------PAALLRRDNDASGR-CTY----------SFTVASPGEVSC-----PE AGSV--------------AQL-REELAALA-------------------------ARLSR LEGAGGVGGSGP----------------------------------------RGADVSGA WS---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------RGPQRAA-------PGGCEELQRAKERLEE---------- -----------------------EKGRLE------------------------------- ------------------------------------------------------------ ---------------------REKEELGRRLESSAQEITRLRAARCPSGTGG-------- ------------------------------------------------------------ -----------------------------------VP-GRDALRSASK------------ ---------------------------------------------ATRWEPEPLGYQELK S--ERTELPASRLL--------EETALGRPR-----------------AED--------- -------SGCGELAWVGEPVVLGRADT----IAGKYGVWMKDPEPVAPFTRETTWRVDTV GTEVRQLFQYEAAEQL-ARGYPAKVHVLPRPLESTGAVVYRGGLFFQPRRSRALARYDLR A-EAISAERELPGAGYHGQYPYSW---GGYTDIDLAVDETGLWVVYSTEKAKGAIVLSKL DPETLEIRRTWE-TNIRKQSVANSFIICGTLYTVSSYSAPNATVNFAYDTATSTS-RSLS IPFENRFRYLSMVDYNPAERRLFAWDSYNMVAYPVRLAHA-------------------- - >XP_513995.2 myocilin [Pan troglodytes] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVWDV-GA------------------ -------------RTARLRKANDQSGR-CHY----------TFSVASPNESSC-----PE QSQAM---SVIHNLQRDSSTQ-RLDLEATK-------------------------ARLSS LESLLHQLTLDQ----------------------------------------AARPQETQ EG-----------------------------------------------------LQKEL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQIREL-------ETAYSNLLRDKSVLEE---------- -----------------------EKKRLR------------------------------- ------------------------------------------------------------ ---------------------QENENLARRLESSSQEVARLRRGQCPQTRDT-------- ------------------------------------------------------------ --------------------------------------ARAVPPGSRE------------ ---------------------------------------------VSTWNLDTLAFQELK S--ELTEVPVSRIL--------KESPSGYLR-----------------SGE--------- -----GDTGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPYTQETTWRIDTV GTDVRQVFEYDLISQF-MQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKL NPENLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIS-KTLT IPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM-------------------- - >NP_001041495.2 myocilin precursor [Canis lupus familiaris] ----------------MPTAQ--------------------------------------- ----------------------------LLLLACLLWGL-EA------------------ -------------RTAQLRKANDRSGR-CQY----------IFSVASPNESSC-----PE QGQAM---SAIQDLQR--------DLESTK-------------------------ARLSS LEGLLHQLTLGQ----------------------------------------AAGPSESQ EG-----------------------------------------------------LHREL GTL--------------------------------------------------------- ------------------------------------------------------------ --RKERE-----------QLETQAREL-------EVAYSNLLRDKSALEE---------- -----------------------EKRRLG------------------------------- ------------------------------------------------------------ ---------------------EENEDLAQRLEHSSQEVARLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPAGSRE------------ ---------------------------------------------VSKWNVETVNFQELK S--ELTEVPASRIL--------KESPSGHPR-----------------NEE--------- -----GDSGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPHTRETTWRIDTV GTDIRQVFEYELASQF-LQGYPSKVHVLPRPLESTGAVVYRGSLYFQGAGSGTVVRYELT A-ETVKAEREIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFVICGHLYTISSYSSPDATVNFAYDTGTGRS-RVLS IPFKNRYKYSSMIDYNPLEKKLFAWDNFNMVTYDIRLSKM-------------------- - >NP_001075619.1 myocilin precursor [Oryctolagus cuniculus] ----------------MPAVQ--------------------------------------- ----------------------------LLLLAGLVWGA-GA------------------ -------------RTAQLRKANDRSGR-CQY----------TFSVASPSESSC-----PE QGQTM---SAIQDLQRDSSTQ-RADLESTK-------------------------ARLSS LESLLHRLTLAQ----------------------------------------TSGPQEIQ EE-----------------------------------------------------LQKEL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLESQTREL-------EAAYSNLLRDKSALEE---------- -----------------------EKRRLM------------------------------- ------------------------------------------------------------ ---------------------QENEDLARRLESSSQEVARLARGQCPQARDT-------- ------------------------------------------------------------ --------------------------------------SQDVPAGSRE------------ ---------------------------------------------ASQWNLDTLAFQELK S--ELTEVPASRIL--------KENPPVLPR-----------------GEE--------- -----GDNGCGELVWVGQPVTLRTAET----ITGKYGVWMRDPKPTSPHTQETTWRIDTV GTDIRQVFEYDRISQF-VQGYPSKVYVLPRSLESTGAVVYAGSLYFQGAGSRTVIRFELN T-ETVKAEKEIPGAGYRGQFPYSW---GGYTDIDLAVDETGLWVIYSTEEARGAIVLSKL NPENLELEKTWE-TNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIS-KPLA IPFKNRYKYSSMIDYNPLERKLFAWDSFNMVTYDIKLSKI-------------------- - >XP_002809846.1 myocilin [Pongo abelii] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVWDV-GA------------------ -------------RTAQLRKANDQSGR-CQY----------TFSVVSPNESSC-----PE QSQAM---SVIRNLQRDSSTQ-RLDLEATK-------------------------ARLSS LESLLHQLTLDQ----------------------------------------AARPQDTQ EG-----------------------------------------------------LQREL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQTREL-------ETAYNNLLRDKSVLEE---------- -----------------------EKKRLR------------------------------- ------------------------------------------------------------ ---------------------QENENLARRLESSSQEVARLRRGQCPQTRDT-------- ------------------------------------------------------------ --------------------------------------ARAVPPGSRE------------ ---------------------------------------------VSTWNLDTLAFQELK S--KLTEVPASRIL--------KESPSGYLR-----------------SRE--------- -----GDNGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPYTQETTWRIDTV GTDVRQVFEYDLISQF-MQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKL NPDNLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSADATINFAYDTGTGIS-KTLT IPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKI-------------------- - >XP_003824704.1 myocilin [Pan paniscus] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVWDV-GA------------------ -------------RTARLRKANDQSGR-CHY----------TFSVASPNESSC-----PE QSQAM---SVIHNLQRDSSTQ-RLDLEATK-------------------------ARLSS LESLLHQLTLDQ----------------------------------------AARPQETQ EG-----------------------------------------------------LQKEL GTL--------------------------------------------------------- ------------------------------------------------------------ --RRERD-----------QLETQIREL-------ETAYSNLLRDKSVLEE---------- -----------------------EKKRLS------------------------------- ------------------------------------------------------------ ---------------------QENENLARRLESSSQEVARLRRGQCPQTRDT-------- ------------------------------------------------------------ --------------------------------------ARAVPPGSRE------------ ---------------------------------------------VSTWNLDTLAFQELK S--ELTEVPVSRIL--------KESPSGYLR-----------------SGE--------- -----GDTGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPYTQETTWRIDTV GTDVRQVFEYDLISQF-MQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKL NPENLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIS-KTLT IPFKNHYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM-------------------- - >NP_001265779.1 myocilin precursor [Felis catus] ----------------MPATQ--------------------------------------- ----------------------------LLLLACLVWGL-GA------------------ -------------RTAQLRKANDRSGR-CQY----------TFSVASPNESSC-----PE QGQAM---SAIQDLQRDSSAQ-RADLESTK-------------------------ARLRS LESLVHQLTLDE----------------------------------------AAGPSATQ EG-----------------------------------------------------LQREL GAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLESQNREL-------EASYSNLLRDKSALEE---------- -----------------------EKRRLR------------------------------- ------------------------------------------------------------ ---------------------EENEDLARRLDSSSQEVARLRRGQCPQARGT-------- ------------------------------------------------------------ --------------------------------------PQDVPSGSRE------------ ---------------------------------------------VSKWNVETVNFQELK S--ELTEVPASRIL--------KESPSGHPR-----------------SEE--------- -----GDPGCGELVWVGEPLTLRRAET----ITGKYGVWMRDPKPAYPYTQETTWRIDTV GTDIRQVFEYDLSSQF-LQGYPSKVHVLPRPLESTGAVVYWGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKL NPESLELERTWE-TNIRKQSVANAFIICGRLYTVSSYSAPDATINFAYDTGTGRS-RALT VPFKNRYKYSSMVDYNPLEKKLFAWDNFNMVTYDLRLSEM-------------------- - >XP_004013742.4 myocilin isoform X1 [Ovis aries] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAQFQKANDRSGR-CQY----------TFSVASPSESSC-----PE QGQAM---SAIQELQRESSEQ-RATLESTK-------------------------ARLSS LEALLHRLTSGQ----------------------------------------PAGPLETQ QG-----------------------------------------------------LQSEL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAYSNLVRDKSALEE---------- -----------------------EKRQLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLENVDFQELK S--ELTEVPASQIL--------KESPSGHPR-----------------NEE--------- -----GGTGCGELVWVGEPITLRTAET----ITGKYGVWMRDPQAAFPYTQETTWRIDTV GTDIRQVFEYDLIRQF-TQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLR T-EALKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSRM-------------------- - >XP_004027946.2 myocilin [Gorilla gorilla gorilla] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVWDV-GA------------------ -------------RTAQLRKANDQSGR-CQY----------TFSVASPNESSC-----PE QSQAM---SVIHNLQRDSSTQ-RLDLEATK-------------------------ARLSS VESLLHQLTLDQ----------------------------------------AARPQETQ EG-----------------------------------------------------LQREL GTL--------------------------------------------------------- ------------------------------------------------------------ --RQERD-----------QLETQTREL-------ETAYSNLLRDKSVLEE---------- -----------------------EKKRLR------------------------------- ------------------------------------------------------------ ---------------------QENENLARRLESSSQEVARLRRGQCPQTRDT-------- ------------------------------------------------------------ --------------------------------------ARAVPPGSRE------------ ---------------------------------------------VSTWNLDTLAFQELK S--ELTEVPASRIL--------KESPSGYLR-----------------SGE--------- -----GDTGCGELVWVGEPLTLRTAET----ITGKYGVWMRDPKPTYPYTQETTWRIDTV GTDVRQVFEYDLISQF-MQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELN T-ETVKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKL NPENLELEQTWE-TNIRKQSVANAFIICGTLYTISSYSSADATVNFAYDTGTGIS-KTLT IPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLSKM-------------------- - >XP_023809784.1 myocilin [Oryzias latipes] ----------------MFLL---------------------------------------- ----------------------------LLLAGLLLQGD-AQ------------------ -------------DQASLWRGNDRSGR-CVY----------SFTVPSPVEASC-----PQ PAA--------------------PEVEALK-------------------------VRLGV LEMLVSQLSGKS----------------------------------------LQPPGGRQ GA-----------------------------------------------------GDR-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AQAEL-------QDALNRAVAERSLLQG---------- -----------------------EKERLK------------------------------- ------------------------------------------------------------ ---------------------REMKALQLRMEEMRRETERLRKRPCPQ-TPAA------P PSHPQRDRAPTRP----------------------------------------------- ----------------------------------------------LE------------ ---------------------------------------------DSAWQYGSPAFQELK A--EVTEVPVP-------------------D-----------------SKQ--------- -----NQTGCGDLLSVGEPVSHRRADN----IAGKYGVWMQDPEPVSPYGPNMVWRIDTV GTEVRQLFGYEDLEQL-SKGFPSKVLLLLDPLESTGATLYRGSLYYQRRLSRTLIRYELA A-EHVAARRELPHAGFHGQFPYSW---GGYTDIDLAVDEKGLWAVYSTSKAQGAIVISLL DPLSLEVRRSWE-TNIRKSSVANSFIICGKMYTVASYSAPDSTINYVYDTETSQG-KAVS IPFKNKYRYNSMIDYSLAQRKLFAWDNFHLVSYDIRMSHS---------PAT-------- - >XP_013223602.1 myocilin [Columba livia] ------------------------------------------------------------ ----------------------------MVRTAG-------------------------- -------------------REEMPGGR-CRE----------R--PGHPNRVTP-----PG PG---------------------------------------------------------R TETSARRSSAGP----------------------------------------RSLQPSG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PGGAGERRKDEAAL------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------GDELGRRLESSAQEIARLRASRCHPGGGG-------- ------------------------------------------------------------ ------------------------------------P-HRDTLRAPGK------------ ---------------------------------------------APRWDPQPLAYQELQ S--ERTEVPASRLL--------EETGLGRPG-----------------SEDL-------- ----GTATGCGELVWVGEPVVFGRADS----IAGKYGVWMKDPEPVPPFTRDTTWRVDTV GTEVRQLFQYEAAEQL-AQGYPTKVHILPQPLESTGAVVYRGGLFFQPRRSRAVARYDLR G-ETVTAEREIPGAGYHGQYPYSW---GGYTDIDLAVDETGLWVIYSTEKARGAIVLSKL DPETLEIRRTWE-TKIRKRGVANSFVICGTLYTVSSYSAPNATINFAYDTATSTS-RALS IPFENRFRYLSMVDYNPTERQLFAWDSFNMVTYPIRLSQA-------------------- - >XP_005690701.2 PREDICTED: myocilin isoform X1 [Capra hircus] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAKFQKANDRSGR-CQY----------TFSVASPSESSC-----PE QGQAM---SAIQELQRESSEQ-RATLESTK-------------------------ARLSS LEALLHRLTSGQ----------------------------------------PAAPLETQ QG-----------------------------------------------------LQTEL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAYSNLVRDKSALEE---------- -----------------------EKRQLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLENVDFQELK S--ELTEVPASQIL--------KESPSGHPR-----------------NEE--------- -----GGTGCGELVWVGEPITLRTAET----ITGKYGVWMRDPQAAFPYTPETTWRIDTV GTAIRQVFEYDLIRQF-TQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLR T-ETLKAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT VPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSPM-------------------- - >XP_006017807.1 myocilin isoform X1 [Alligator sinensis] ----------------MLVAC--------------------------------------- ----------------------------LLLSLSLLQGA-LG------------------ -------------STVHLRRANDRHGR-CTY----------SFTVPSPHEASC-----PG SDQAM---PAILDLQRESNMQ-RSELESAK-------------------------ARLSL LESLVTQSHAME-----------------------------------------DSSASTV ES-----------------------------------------------------LQRQL ASL--------------------------------------------------------- ------------------------------------------------------------ --RMETT-----------QQKSQASRM-------ETAYRDLLRNKSSLEE---------- -----------------------EKRHLE------------------------------- ------------------------------------------------------------ ---------------------REKEELERRLENSSQEITQLRANQCPQVRDT-------- ------------------------------------------------------------ ------------------------------------P-VPDSLQRSKK------------ ---------------------------------------------VSRWDMESPDYQELK S--EMTEVSASSLF--------QER-SSHSRL---------------GAED--------- ----TGTAGCGELVWVGEPVTLRKAET----IVGKYGVWMKDPEPASPYTRETTWRIDTV GTDIRQVFEYDSADQF-MQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLR K-ETITVQKDLTNAGYHGQFPYSW---GGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTL DPETLEIRQTWE-TNIRKQSVANSFMICGTLYTISSYSSPDAMIHFAYNTATSTR-KLLK IHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLSKM-------------------- - >XP_014460702.1 PREDICTED: myocilin isoform X1 [Alligator mississippiensis] ----------------MLVAC--------------------------------------- ----------------------------LLLSLSLLQGA-LG------------------ -------------STVHLRRANDRHGR-CTY----------SFTVPSPHEASC-----PG SDQAM---PAILDLQRESNMQ-RSELESAK-------------------------ARLSL LESLVTQSHAME-----------------------------------------GSSASTV ES-----------------------------------------------------LQRQL ASL--------------------------------------------------------- ------------------------------------------------------------ --RMETT-----------QQKSQASRM-------ETAYRDLLRNKSSLEE---------- -----------------------EKRHLE------------------------------- ------------------------------------------------------------ ---------------------REKEELERRLENSSQEIAQLRANQCPQVSDT-------- ------------------------------------------------------------ ------------------------------------P-VPDSLQRSKK------------ ---------------------------------------------VSRWDMESPDYQELK S--EMTEVSASSLF--------QEH-SSHSRL---------------GAED--------- ----TGTAGCGELVWVGEPVTLRKAET----IAGKYGVWMKDPEPASPYTRETTWRIDTV GTDIRQVFEYDSTDQF-IQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLR K-ETITVQKDLTNAGYHGQFPYSW---GGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTL DPETLEIRQTWE-TNIRKQSVANSFMICGTLYTISSYSSPDAMIHFAYNTATSTR-KLLK IHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLSKM-------------------- - >XP_015832476.1 PREDICTED: myocilin [Nothobranchius furzeri] ----------------MFFLL--------------------------------------- ---------------------------SLCIFGLLLRGD-AQ------------------ -------------ERASLWRGNDRSGQ-CQY----------TFTVPSPAEASC-----PQ ASA--------------------PEVEGLK-------------------------ARLSI LEALVSQLSGKD----------------------------------------TQSPGGQR GA-----------------------------------------------------SVR-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------GHSEL-------QETLNRAVGERNLLQG---------- -----------------------EKERLE------------------------------- ------------------------------------------------------------ ---------------------MELEGLRLRMEEMRRETERLRNRPCLPQNPVV------P PSFPQRDRSPVRPAVGSNQMSH-------------------------------------- --------------------------------LMTRP-NRQGDSSSLR------------ ---------------------------------------------DSAWQYGSQGFQELK A--DVTEVPAP-------------------D-----------------SHQ--------- -----DNTGCGTLVSVGDPVTHRKADS----IAGKYGVWMQDPEAVSPYGPSMVWRIDTI GTDVRQLFGYDDMEQL-SKGFPSKVLLLPDPLESTGATLYRGSLYYQRRLSRSLIRYDLA A-EHVAARRELPHAGFHGQFPYSW---GGYTDIDLSVDEKGLWAVYSTNKAQGAIVISQL DPQTLEVKKSWE-TNIRKASVANSFIICGKMYTVASYAAHNTVINYMFDTETSQG-RAVS IPFKNRYGYNSMVDYSMAQRKLFAWDNFHLVTYDISLGRQ---------QVN-------- - >XP_020727692.1 myocilin [Odocoileus virginianus texanus] ----------------MPAVQ--------------------------------------- ----------------------------LLLLACLVGGV-GA------------------ -------------RTAQFQKANDQSGR-CQY----------TFRVASPSESSC-----PE QDQAM---SAIQELQRDSRDQ-RATLEATK-------------------------ARLSS LEAVLHRLTSGQ----------------------------------------PTGPLEAQ QG-----------------------------------------------------LQKEL EAL--------------------------------------------------------- ------------------------------------------------------------ --RRERE-----------QLETQTREL-------ESAFSNLVRDKSALEE---------- -----------------------EKRQLQ------------------------------- ------------------------------------------------------------ ---------------------AENEDLARRLESSSQEVASLRRGQCPQAHSS-------- ------------------------------------------------------------ --------------------------------------SQDVPSGSRE------------ ---------------------------------------------VAKWNLENVDFQELK S--ELTEVPASQIL--------KEGLSGHPR-----------------SEE--------- -----EGTGCGELVWVGEPVTLRTAET----ITGKYGVWMRDPQAAYPYTRETTWRIDTV GTDIRQVFEYDLSGQF-AQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAKSRTLLRYDLR T-ETLQAEKEIPGAGYHGQFPYSW---GGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKL NPETLELEQTWE-TNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSS-KALT IPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLSRM-------------------- - >XP_030289193.1 myocilin [Sparus aurata] ----------------MFLLL--------------------------------------- ---------------------------SLCVSGLLLNAD-AQ------------------ -------------ERASLWRGNDRAGR-CQY----------TFSVPSPVESSC-----PQ TGG--------------------PEMEGLK-------------------------ARLGM LEVLVARLTGGE----------------------------------------TVAP---Q RA-----------------------------------------------------GAR-- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------AQTEL-------QEALNRATGERNLLQG---------- -----------------------EKERLE------------------------------- ------------------------------------------------------------ ---------------------RELMGLQGRMEEMRKETERLRNRPCPPLIPVV------Q PSPSLQGGGLMRPAGGSSAMSH-------------------------------------- --------------------------------LMTRP-NRQGDSSSLR------------ ---------------------------------------------DSAWQYRSPGFQELK A--EVTEVPAP-------------------D-----------------GSE--------- -----ENTGCGELVSVGEPVTHRKADN----IEGKYGVWMQDPEAASIYGPNMIWRIDTI GSDVRKLFGYDDMEQL-AKGFPSKVLLLPEQVESTGATVYRGSLYFQRRLSRTLIRYDLA S-ESVAARRELPHAGFHGQFPYSW---GGYTDIDLAVDEQGLWAVYSTSKAKGAIVISKL DPGSLEVKKSWE-TNIRKSSVANSFIICGKLYTVASYTAPDTIINYMYDTETSQG-KAVS IPFRNKHRYNSMIDYNRAQRKLFAWDNYHMVSYDIKLGRQ---------QAN-------- - >XP_040216066.1 myocilin [Rana temporaria] ----------------MGFFT--------------------------------------- ----------------------------LNILVPLVFCL-AQ------------------ -------------GSPQLRRANDRQGQ-CTY----------TFTVPSPSEGSC-----TE PGEAM---TSIRELQLENAAR-TQETAGLQ-------------------------TRVSL LENMVNKFLGGKD------------------------------------LQQATSSPQSW SD-----------------------------------------------------NQKEM ETL--------------------------------------------------------- ------------------------------------------------------------ --RMQKD-----------EWEGQRVSL-------EMAYSDLLKEKTSLEE---------- -----------------------DKQRLT------------------------------- ------------------------------------------------------------ ---------------------ERLE----RVQGQCPPVTEVSRNRDQRVSPRQ------G PSPAEIH------GTGGRT-SP-------------------------------------- -----------------------------------VA-ARD---GTAD------------ ---------------------------------------------LSRWGADGMGYQELK S--ELTALPASRMI--------PENRSAVES-----------------LQNI-------- ----KMGGSCGEITWVGEPTTYRKADN----IAGKYGVWMRDPEPVSPFNEETIWRINTV GADIRQVFEYENLDQL-VKGYPTKVYVVPRSMESNGAVIYKSSLYYVRRKSRIIVKYDFK T-ETVAIQKELSDAGYHGQHPYSW---GGYTDIDLAVDELGMWAIYSTDKTKGSIVISQL NPKTLEVNQSWE-TTIRKHSVANAFMACGTLYTVGSYSSTNTTINFAYDTHTGVQ-KQIS VPFKNQYGYGSMVDYNPREKKIYGWDNYNMVSYDVRLSKM-------------------- - >XP_039269227.1 myocilin-like [Styela clava] MLLRYSSKSVAILLMTMQTLAISKSEDIVGDDDSSNIVDELD---RPL----SFNQ---- -NFKTT-APQGPSTTALTDNVHNGDPVTTLLMSPDQYGQVASSEVIHQPARPGVGPNRPL MGQQSRRNSNIFYTTGQQSSNARQSGRTCQY----------IFTVENADHCTH-----TT TEIAV---NHVARTTLPMQQS-KNILDEYS-------------------------ERLRK LERTVYGETAGQQSENIQRDSSM--------------ITEVVAHNME-MPGQTTSPDEST QTKPIS----------------------------------LVE--------IAQQMIKQL ATLE-----------------------KGI------------------------------ ------------------------------------------------------------ -VRSEKERE---------DLRKQNKNLIFTLRRSSAARKNLASSKSELEKNLLKEKDKYM QLCNSNRSLSL-----QNEALRSHKAKLE------------------------------- ------------------------------------------------------------ ---------------------TVQESFRKRIHVLETEKEQLSRTATHWQRKH-------- -SELEIANDVLKMRVHNFS-GT-------------------------------------- --------------------------------LE----NCNKLTAKGE------------ ---------------------------------------------LLQQQIE---LEQEK N--KILVVNNSQLM--------KQLENATSRIKLLQEEIARDTIFSSGGQDLPVYTSGVR RMNDQDYSYCGRITSISMPETVRGPQSYSNRIFEKYGVWMTDP--LEAMGKGIVWSIDTT KERAKVLKQYESLQMY-ILNRPQQIIALTIPVESTGGVVYNGSFYYQRRNSRKLVRYDLR T-RRVMRERPVHHAGFHGMFAYQW---GGFTDIDLAVDEFGLWVIYSTRQNDGNIVVSRL NPVSLRSLMTMK-TSIPKRTVANAFMACGILYTVDSYDAANASLNYEFDTFRKKL-KRIS IPFANQHRYNVMIDYNPQTREIYSWDNSHQVKYYVTLDKT----MGKISQLTQRNGRIHR G >XP_011677256.1 amassin 4 isoform X1 [Strongylocentrotus purpuratus] M----------AFSRIMISPA--------------------------------------- ------------------------ALAMLFIVAFRCMSN-ANAQCN-------------- -------------EYAHVNSSVTENGD-CVC------------GVTSSLSSSC------G SGVSS---AEFQQMIRDLDQQ-VCTIVDIN-------------------------VELIT LRVTFNQ--QGED------------------------IIA-------------------- -------------------------------------------------------MHEQM DNI--------------------------------------------------------- ------------------------------------------------------------ --NAIKE-----------RIIDNKIVI------SSPEYDVIRMDLQDMET---------- -----------------------LISYLE------------------------------- ------------------------------------------------------------ ---------------------DQNAD-QFIIVKLREEIANISYNLDSLEVNN-------- ------------------------------------------------------------ --------------------------------------DGDIESLLRD------------ -------------------------------------------------------IADLQ Q--QIAECEADN---------DPDSEIGFPY----------------PWENF-------- ----ETKDSCGTIRGLSEPYTLRGNLA-------STGVWFMDPIVDV----DRPW-YQVG VTTASSILRYLSIEQF-QTEGIHETYLPGYTLEGCSVVAYNGALFYNMYGSATIIRYDYR E-GSVTNQRALPNAGYKTNYVYLS---GGYTSMDFAVDEQGLWVIYGKSTNSGLMSVSKI DPLTLEVEETYN-TNTLKANFGECFMVCGKLYCTDSFNKHDGRIVMMYDTTTQTS-TTLN VPFDSKYLATRALKYNPRDQRLYAFNNGHALVYEIEFQVDE------------------- - >XP_038073533.1 collagen alpha-1(I) chain-like [Patiria miniata] ----------------MTTCALLK----MAGDKTN------------------------- ---------VC--AHALHVKILYFGLALLFVFSATCFGV--------------------- -------------TYVFVASLSAELGQKCSCP---DGEILLDITVLPPSGSTGDSPRGPR QAAAARHGSDNQQVRAELGLK-TANIVADKPG----------------------TADLRG LNRVRRGFTHGDQESSSPRATSIEAYARLPITISLDSITAFCNKTTSRCPPGPQGPAGKE GGLGIQGPPGNQGDEGPVGAPGRPGEDGKNCNCSTDDFAVLLEKTAELAGNIGQPGPKGD TGQPGPKGESGDPGIPGPQGLSGEAGPKGVKGDTGYRGPMGQTGGQGTIGPVGEKGAPGD RGLQGFDGPQGRRGEPGRKGEVGEPGPTGPPGLTGPKGDPGSPGDHGRHGKHGEKGDRG- -LRGEKGVSGFPGS---IGLRGSRGDI--GLPGVQGPQGEAGRDGSNCSC-IDPDGDMMT KFLIPTSAV--------------EKQQLTGPPGPPGPEGPKGDIGDRGLQGPPGPN---- ----GTAAVKGQKGDIGETGPIGPLGSRGRRGDPGQTGARGDKGDTGREGPTGPEGAAGQ KGEKGEPGVMGDTGPIRQPGTRETVSEACNVTAFLEELMELDNRTLKLIQGPPGPRGSPG PSGPEGKQG--KQGPQGLK-GDPGELGRAGPQGPIGPPGAKGTPGAKGLAGSFGYPG--D PGEKGAT------GPPGPRGSTGDPGLPGPPGIDGRPGSKGEMGDKGDRGVDGLPGQTGA QGLPGADGTQGSAGQTGDKGARGKLGPAGQPGEDGASGPKGEKGEKGDRGIASGMVELGN A--GDDEKPASGKAT---YGPTPTAKPSKPQ----------------PSPDV-------- ---DSSPNSECVLTKIGFPVDHKFGNK-------YWGSWMQDTAPNPPYP-DKIW--VTK HLVGDGIYEYKNMAAL-MSDSYTQYHRLTGAWAGTGHVVYNNALYFHNGGSGKIVQYDLT L-ETVTAQATIPEALYQRSNGHRYLYDSDYTYLDLAVDDNGLWVIYKTAENHQNLVVSQL DPENLSVIKTVV-SNHPQSSAGDAFIICGRLYTTKSSKNFHSTVDFAVNLFTGEVLPDVD ISYQNGHMKMTMMSYNPRKRLIYAWDKGYMVTYNVTLTEP-------------------- - >NP_573262.2 uncharacterized protein Dmel_CG6867 [Drosophila melanogaster] MFL--------AVNQSLQNTSKKKRKRRTAEDDPQEDSGEGTPPVRPLEPSASSDQLVGV GNGATCRVCKCPGRQSLTLVYIYLGALTLILASLSIVFY-THTQDVESLSQ--VEDN--- YSSKSFRVQ----FQAELMRSEEELRRLVNRIIEEEQELVGSTTASSTTQSRD-----PL KNERKFTDNLISHTTRPTGKRMRRDIASSAPASMHADPLIEFFNPNHRKVLEEQDTEIRK RTGQKGAAPGGDE------WIYLNTYCRVPEKI----ITGFCKGTQDYCPPAPQGPTGEV GPKGPP-------------------------------------------------GNPGL PGIPGPKGNRGDVGLPGAPGV------DGV----------------GHLGPAGPRGPKGD AGATGRAGLDGRDGVP------GEPGLDGVPGRAGADGKNGLPGRDGKDGLHGKDGKDGL SITGPKGAQGPPGERGLKGIAGPRGRP--GKPGTNGIPGVPGINAWKLQY---PNGSSSN DLLIPPSITDIQVPDFQRTVIVEEGRSLN---------------LSCTATGTPTPQVEWR REDGRTINVNGV-----EMASISGQFLRFTNITRHQMAAYTCFANNG----IAPVANATY LVEVQFAPMISVYRQMIYAEYQSSATLECLVEAFPEAIRYWERAYDGKILDPSDKYG--I ESYPEGFKTTMRLTISNLR-KD-----------------------------DFGYYHCVA RNELNATMVNFEIAPQDPNSE--------------TPYVGNNMKVYGQR----------- --------------------------------------PPESECPVCDQCPDPSLYQCKD SILNNFEIQATGNL---------------------------------SYPGL-------- ----PKRPKTCYLYAVGKPVFHKVVNE-------KFGSWLRDPSPDS----DREKTFVTN ENDPYNLFEFTTRIQYRMNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLT SLKKITTQ--LPYAGVAAANRLYT---TDYNYMDFNVDEVGLWVIYSTYNSNNTL-VAKL DAETLKMQYNFN-ITLDHHQFGEMFIVCGNLYAIDSGTDKNTQIRYVVDLYKGKL-LNTN LPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRYNEQ---------RLISDNS---- - >NP_491804.2 Olfactomedin-like domain-containing protein [Caenorhabditis elegans] M----------EENLHYCNLA--------------------------------------- ----------------------------ITLIAVLAFSH--------------------- -------------IHYRIWTLESE----CQS--------LTELNFRSKRDIPL------S RGKNA---SDILWLTSLSSVK-IGELMHKC-------------------------TEIHE YCSEQDDVRGKPG------------------------------------PVGPVGPPGKS GPAGPQ-------------------------------------------------GRRGL MGIP-------------------------------------------------------- ----------------------GHPGPVGPPG---------------------------- --NIGKD---------------------------ADCSSCPIRDELLMER---------- EFKCP------------------TIENLE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------CP-NREAIPTTPW------------ --------------------------------------------PSVTHQPMPGLVQQIL S--NYSEVEGCVKICLKNYTLDEEIEETITT----------------PVAYI-------- ----QGVTAHCRLQNVGKPVFHSHSTT-------YYGSWMRDAYP--PTGDDARKRYVMN HFQGHELIEFRNEAEM-RRDHVGKVHRLPYIFDGTNHVIFNASLFYQRAGYPIIAKYEFN S-KQYS-QFEIPGAAYRGDQYLYN---NSMNYFDLAIDENALWVMFHYQE-EAFLSVAKV DINNLTIYEAFNLTTVNHTDVANGIVVCGTIYLVESASEQSTYISTAYDFYRNTY-SQPL IKWINLYKNANMISYNAYDKRIYIYDHGYMLSVPPLLHWL--------AK---------- -
BMGE Cleaned alignment of selected proteins >sp|Q99972|MYOC_HUMAN Myocilin OS=Homo sapiens OX=9606 GN=MYOC PE=1 SV=2 MPAVQLLLLACLVWDVRTAQLRKANDQSGRTFSVASPNESSCPEQSQAMSVIHNLQRDSSRLDLEATKARLSSLESLLHQLTLDQAARPQLQRELGTLRRERDQLETQTRELNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQPGSREVSTWNLDTLAFQELKSELTEVPASRILSGYLRTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYTSADATVNFAYDTGTGIKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS >tr|Q5F0G5|Q5F0G5_DANRE Myocilin OS=Danio rerio OX=7955 GN=myoc PE=2 SV=1 MWFLALWISSLLMGSQSSANLRRANAGNGRTFMVDSPTEASCPSPGST-------------PEMEALMSRLGLLEALVARLVGGEAMPES-------------------SGLQVMGENAQLKREKQRLDRQVQDLQQRMEELRQEAERLRSRPCMQKSSLRDPAWQYSNPGYQELTAVVTEVTAPN-----QDSGCGDLVWVENPEVHRKADSIAGKYGVWMQDPEAKEPYGPDMVWRIDSVGSEVRQLFGYENRGFPTKVLLLPESVESTGATMYKGSLYYQRRLSRTLIRYDLHAESIAARRDLPHAGFHGQFPYSWGGYTDIDLAIDENGLWAIYSTNKAKGAIVISQLDPHNLEVKGTWETKIRKTSVANAFMICGKLYTVASYTSPNTTVNYMFDTATSQKAISVPFKNRYRYNSMVDYNSAKRKLYAWDNYYMVSYSVRLG >NP_034995.3 myocilin precursor [Mus musculus] MPALHLLFLACLVWGMRTAQFRKANDRSGRTFTVASPNESSCPREDQAMSAIQDLQRDSSHADLESTKARVRSLESLLHQMTLGRVTGTQLQGQLGALRRERDQLETQTRDLNLLRDKSALEEEKRQLEQENEDLARRLESSSEEVTRLRRGQCPSPGSREVSQWNLDTLAFQELKSELTEVPASQILSGRPRKGCGALVWVGEPVTLRTAETIAGKYGVWMRDPKPTHPYTQESTWRIDTVGTEIRQVFEYSQQGYPSKVHVLPRALESTGAVVYAGSLYFQGAESRTVVRYELDTETVKAEKEIPGAGYHGHFPYAWGGYTDIDLAVDESGLWVIYSTEEAKGAIVLSKLNPANLELERTWETNIRKQSVANAFVICGILYTVSSYSSAHATVNFAYDTKTGTKTLTIPFTNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLL >KAB0377578.1 hypothetical protein FD755_012022 [Muntiacus reevesi] MPAVQLLLLACLVGGVRTAQFQKANDQSGRTFRVASPTESSCPVQDQAMSAIQELQRDSSRATLEATKARLSSLEAVLHRLTSGQPTGPLLQRELEALRREREQLETQTRELNLIRDKSALEEEKRRLQAENEDLARRLESSSQEVASLRRGQCPQSGSREVAKWNLENVDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPVTLRRAETITGKYGVWMRDPQAADPYTAETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPVESTGAVVYRGSLYFQAAESRTLLRYDLRAETLRAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLS >KAB0345677.1 hypothetical protein FD754_022603 [Muntiacus muntjak] MPAVQLLLLACLVGGVRTAQFQKANDQSGRTFRVASPTESSCPVQDQAMSAIQELQRDSSRATLEATKARLSSLEAVLHRLTSGQPAGPLLQRELEALRREREQLETQTRELNLIRDKSALEEEKRRLQAENEDLARRLESSSQEVASLRRGQCPQSGSREDSGFNLESETTQQTKSGMLHIRITD-----ERQRCGELVWVGEPVTLRRAETITGKYGVWMRDPQAADPYTAETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPVESTGAVVYRGSLYFQAAESRTLLRYDLRAETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFVICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLS >XP_043341789.1 myocilin [Cervus canadensis] MPAVQLLLLACLVGGVRTAKFQKANDQSGRTFRVASPSESSCPEQDQAMSAIQELQRDSSRATLEATKARLSSLEAILHRLTSGQPTGPLLQKELEALRREREQLETQTRELNLVRDKSALEEEKRRLQAENKDLARRLESSSQVVASLRRGQCPQSGSREVAKWNLEKVDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPVTLRTAETITGKYGVWMRDPEAAYPYTRETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTLLRYDLRAETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLS >OCT82906.1 hypothetical protein XELAEV_18025441mg [Xenopus laevis] MGSLALHIVVTLWV--ISGQFSRSSDLNGQSFTVPSATEASCTEPGQAKSVIQELQLELSHKDMETLNTRLGLLEKIVNRFLGGEPSTGPLQVEVQKLRMEKDEWEGQRASLDLLKEKDSLQEEKLQLNQRLE---TVLQGQCPQVSDPSRTQVPDAPSRQVSRWGADPVGYQELKSELTALPASQMILANHSGTCGELTWIGEPTTYRKADNIAGKYGVWMRDPKPLAPYTMDTVWRVNTVGADIRQVFEYENKGYPGKVYVLPRSMESNGAVIYKGSLYYPRRKSRILVKYDFKTESVAVQKELPNAGYHGQYPYSWGGYTDIDLAVDEVGLWAIYSTEKAKGSIVLSLLDSESLEVKQSWESQIRKQSVANAFMICGTLYTVGSYSSSSTTVNFAFDTSTGARPVGIPFKNQYGYASMIDYNPTEKKIYGWDNFNMVSYDVRLS >OWK08457.1 MYOC [Cervus elaphus hippelaphus] MPAVQLLLLACLVGGVRTAKFQKANDQSGRTFRVASPSESSCPEQDQAMSAIQELQRDSSRATLEATKARLSSLEAILHRLTSGQPTGPLLQKELEALRREREQLETQTRELNLVRDKSALEEEKRRLQAENKDLARRLESSSQVVASLRRGQCPQSGSRE---------------------------------GCGELVWVGEPVTLRTAETITGKYGVWMRDPEAAYPYTRETTWRIDTVGTDLRQVFEYDLQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTLLRYDLRAETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLS >NP_110492.2 myocilin precursor [Rattus norvegicus] MPALQLLFLACLVWGMRTAQFRKANDRSGRTFTVASPSESSCPREDQAMSAIQDLQRDSSHADLESTKARVRSLESLLHQMTSGGVTGTQLQGQLGALRRERDQLETQTRDLNLLRDKSALEEEKRQLEQENKDLARRLEGSSQEVARLRRGQCPSPGSREVSQWNLDTLAFQELKSELTEVPASQILSGHPRKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTHPYTQETTWRIDTVGTGIRQVFEYSQQGYPSKVHVLPQALESTGAVVYAGSLYFQGAESRTVLRYELNTETVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYSTEENRGAIVLSKLNPENLELESTWETNIRKQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGIKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLS >NP_776543.2 myocilin precursor [Bos taurus] MPAVQLLLLACLLGGVRTAQFQKANDRSGRTFSVASPSESSCPEQGQAMLAIQELQRDSSRATLESTKARLSSLEALLHRLTSGQPAGPLLQRELEALRREREQLETQTQELNLVRDKSALEEEKRRLQAENEDLARRLESSSQEVASLRRGQCPQSGSREVAKWNLENMDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPITLRTAETITGKYGVWMRDPQATFPYTGETTWRIDTVGTDIRQVFEYDHQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLS >NP_999151.1 myocilin precursor [Sus scrofa] MPAVQLLLLACLVWSARTAQLWKANDRSGQTFKVASPNESSCPEQGQTMSALQDLQRDSSRAALESTKARLSSLEALLHRLILGQATGPWLEKELGTLRREREQLETQNRELNLTRDKSALEEEKRQLETENEDLARRLESSSQELAKLKV-QCPQLGSREVSKWNVENLDFQELKSELTEVPAARILSGHSGSGCGELVWVGEPVTLRTAETITGKYGVWMRDPKATYPYTQETTWRIDTVGTDIRQVFEYDRQGYPSKVHVLPRRLESTGAVVYQGSLYFQGASSRTVIRYELSTETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPENLELERTWETNIRKQSVANAFIICGTLYTVSSYSSPEATINFAYDTSTGSKALTIPFKNRYEYSSMIDYNPLEKKLFAWDNFNMVTYDIRLS >XP_015145920.3 myocilin [Gallus gallus] MPGAWLLLAGGLALSAPAALLRRDNDASGRSFTVASPGEVSCPEAGSV-----------AREELAALAARLSRLEGAGGVGGSGPRGADV---------------RGPQRAAELQRAKERLEEEKGRLEREKEELGRRLESSAQEITRLRAARCPSRSASKATRWEPEPLGYQELKSERTELPASRLLLGRPRSGCGELAWVGEPVVLGRADTIAGKYGVWMKDPEPVAPFTRETTWRVDTVGTEVRQLFQYEARGYPAKVHVLPRPLESTGAVVYRGGLFFQPRRSRALARYDLRAEAISAERELPGAGYHGQYPYSWGGYTDIDLAVDETGLWVVYSTEKAKGAIVLSKLDPETLEIRRTWETNIRKQSVANSFIICGTLYTVSSYSAPNATVNFAYDTATSTRSLSIPFENRFRYLSMVDYNPAERRLFAWDSYNMVAYPVRLA >XP_513995.2 myocilin [Pan troglodytes] MPAVQLLLLACLVWDVRTARLRKANDQSGRTFSVASPNESSCPEQSQAMSVIHNLQRDSSRLDLEATKARLSSLESLLHQLTLDQAARPQLQKELGTLRRERDQLETQIRELNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQPGSREVSTWNLDTLAFQELKSELTEVPVSRILSGYLRTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS >NP_001041495.2 myocilin precursor [Canis lupus familiaris] MPTAQLLLLACLLWGLRTAQLRKANDRSGRIFSVASPNESSCPEQGQAMSAIQDLQR-----DLESTKARLSSLEGLLHQLTLGQAAGPSLHRELGTLRKEREQLETQARELNLLRDKSALEEEKRRLGEENEDLAQRLEHSSQEVARLRRGQCPQAGSREVSKWNVETVNFQELKSELTEVPASRILSGHPRSGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPHTRETTWRIDTVGTDIRQVFEYELQGYPSKVHVLPRPLESTGAVVYRGSLYFQGAGSGTVVRYELTAETVKAEREIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFVICGHLYTISSYSSPDATVNFAYDTGTGRRVLSIPFKNRYKYSSMIDYNPLEKKLFAWDNFNMVTYDIRLS >NP_001075619.1 myocilin precursor [Oryctolagus cuniculus] MPAVQLLLLAGLVWGARTAQLRKANDRSGRTFSVASPSESSCPEQGQTMSAIQDLQRDSSRADLESTKARLSSLESLLHRLTLAQTSGPQLQKELGTLRRERDQLESQTRELNLLRDKSALEEEKRRLMQENEDLARRLESSSQEVARLARGQCPQAGSREASQWNLDTLAFQELKSELTEVPASRILPVLPRNGCGELVWVGQPVTLRTAETITGKYGVWMRDPKPTSPHTQETTWRIDTVGTDIRQVFEYDRQGYPSKVYVLPRSLESTGAVVYAGSLYFQGAGSRTVIRFELNTETVKAEKEIPGAGYRGQFPYSWGGYTDIDLAVDETGLWVIYSTEEARGAIVLSKLNPENLELEKTWETNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIKPLAIPFKNRYKYSSMIDYNPLERKLFAWDSFNMVTYDIKLS >XP_002809846.1 myocilin [Pongo abelii] MPAVQLLLLACLVWDVRTAQLRKANDQSGRTFSVVSPNESSCPEQSQAMSVIRNLQRDSSRLDLEATKARLSSLESLLHQLTLDQAARPQLQRELGTLRRERDQLETQTRELNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQPGSREVSTWNLDTLAFQELKSKLTEVPASRILSGYLRNGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPDNLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSADATINFAYDTGTGIKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS >XP_003824704.1 myocilin [Pan paniscus] MPAVQLLLLACLVWDVRTARLRKANDQSGRTFSVASPNESSCPEQSQAMSVIHNLQRDSSRLDLEATKARLSSLESLLHQLTLDQAARPQLQKELGTLRRERDQLETQIRELNLLRDKSVLEEEKKRLSQENENLARRLESSSQEVARLRRGQCPQPGSREVSTWNLDTLAFQELKSELTEVPVSRILSGYLRTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSADATVNFAYDTGTGIKTLTIPFKNHYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS >NP_001265779.1 myocilin precursor [Felis catus] MPATQLLLLACLVWGLRTAQLRKANDRSGRTFSVASPNESSCPEQGQAMSAIQDLQRDSSRADLESTKARLRSLESLVHQLTLDEAAGPSLQRELGALRREREQLESQNRELNLLRDKSALEEEKRRLREENEDLARRLDSSSQEVARLRRGQCPQSGSREVSKWNVETVNFQELKSELTEVPASRILSGHPRPGCGELVWVGEPLTLRRAETITGKYGVWMRDPKPAYPYTQETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPLESTGAVVYWGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTQEAKGAIVLSKLNPESLELERTWETNIRKQSVANAFIICGRLYTVSSYSAPDATINFAYDTGTGRRALTVPFKNRYKYSSMVDYNPLEKKLFAWDNFNMVTYDLRLS >XP_004013742.4 myocilin isoform X1 [Ovis aries] MPAVQLLLLACLVGGVRTAQFQKANDRSGRTFSVASPSESSCPEQGQAMSAIQELQRESSRATLESTKARLSSLEALLHRLTSGQPAGPLLQSELEALRREREQLETQTRELNLVRDKSALEEEKRQLQAENEDLARRLESSSQEVASLRRGQCPQSGSREVAKWNLENVDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPITLRTAETITGKYGVWMRDPQAAFPYTQETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTEALKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLS >XP_004027946.2 myocilin [Gorilla gorilla gorilla] MPAVQLLLLACLVWDVRTAQLRKANDQSGRTFSVASPNESSCPEQSQAMSVIHNLQRDSSRLDLEATKARLSSVESLLHQLTLDQAARPQLQRELGTLRQERDQLETQTRELNLLRDKSVLEEEKKRLRQENENLARRLESSSQEVARLRRGQCPQPGSREVSTWNLDTLAFQELKSELTEVPASRILSGYLRTGCGELVWVGEPLTLRTAETITGKYGVWMRDPKPTYPYTQETTWRIDTVGTDVRQVFEYDLQGYPSKVHILPRPLESTGAVVYSGSLYFQGAESRTVIRYELNTETVKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEAGLWVIYSTDEAKGAIVLSKLNPENLELEQTWETNIRKQSVANAFIICGTLYTISSYSSADATVNFAYDTGTGIKTLTIPFKNRYKYSSMIDYNPLEKKLFAWDNLNMVTYDIKLS >XP_023809784.1 myocilin [Oryzias latipes] MFLL-LLLAGLLLQGDDQASLWRGNDRSGRSFTVPSPVEASCPQPAA--------------PEVEALKVRLGVLEMLVSQLSGKSLQPPGGDR--------------AQAELRAVAERSLLQGEKERLKREMKALQLRMEEMRRETERLRKRPCPQ---LEDSAWQYGSPAFQELKAEVTEVPVP-------DTGCGDLLSVGEPVSHRRADNIAGKYGVWMQDPEPVSPYGPNMVWRIDTVGTEVRQLFGYEDKGFPSKVLLLLDPLESTGATLYRGSLYYQRRLSRTLIRYELAAEHVAARRELPHAGFHGQFPYSWGGYTDIDLAVDEKGLWAVYSTSKAQGAIVISLLDPLSLEVRRSWETNIRKSSVANSFIICGKMYTVASYSAPDSTINYVYDTETSQKAVSIPFKNKYRYNSMIDYSLAQRKLFAWDNFHLVSYDIRMS >XP_013223602.1 myocilin [Columba livia] -----MVRTAG-----------REEMPGGRR--PGHPNRVTPPGPG--------------------------RTETSARRSSAGPRSLQP----------------------ERRKDEAAL----------GDELGRRLESSAQEIARLRASRCHPRAPGKAPRWDPQPLAYQELQSERTEVPASRLLLGRPGTGCGELVWVGEPVVFGRADSIAGKYGVWMKDPEPVPPFTRDTTWRVDTVGTEVRQLFQYEAQGYPTKVHILPQPLESTGAVVYRGGLFFQPRRSRAVARYDLRGETVTAEREIPGAGYHGQYPYSWGGYTDIDLAVDETGLWVIYSTEKARGAIVLSKLDPETLEIRRTWETKIRKRGVANSFVICGTLYTVSSYSAPNATINFAYDTATSTRALSIPFENRFRYLSMVDYNPTERQLFAWDSFNMVTYPIRLS >XP_005690701.2 PREDICTED: myocilin isoform X1 [Capra hircus] MPAVQLLLLACLVGGVRTAKFQKANDRSGRTFSVASPSESSCPEQGQAMSAIQELQRESSRATLESTKARLSSLEALLHRLTSGQPAAPLLQTELEALRREREQLETQTRELNLVRDKSALEEEKRQLQAENEDLARRLESSSQEVASLRRGQCPQSGSREVAKWNLENVDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPITLRTAETITGKYGVWMRDPQAAFPYTPETTWRIDTVGTAIRQVFEYDLQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLS >XP_006017807.1 myocilin isoform X1 [Alligator sinensis] MLVACLLLSLSLLQGASTVHLRRANDRHGRSFTVPSPHEASCPGSDQAMPAILDLQRESNRSELESAKARLSLLESLVTQSHAME-DSSALQRQLASLRMETTQQKSQASRMDLLRNKSSLEEEKRHLEREKEELERRLENSSQEITQLRANQCPQQRSKKVSRWDMESPDYQELKSEMTEVSASSLFSSHSRAGCGELVWVGEPVTLRKAETIVGKYGVWMKDPEPASPYTRETTWRIDTVGTDIRQVFEYDSQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLRKETITVQKDLTNAGYHGQFPYSWGGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTLDPETLEIRQTWETNIRKQSVANSFMICGTLYTISSYSSPDAMIHFAYNTATSTKLLKIHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLS >XP_014460702.1 PREDICTED: myocilin isoform X1 [Alligator mississippiensis] MLVACLLLSLSLLQGASTVHLRRANDRHGRSFTVPSPHEASCPGSDQAMPAILDLQRESNRSELESAKARLSLLESLVTQSHAME-GSSALQRQLASLRMETTQQKSQASRMDLLRNKSSLEEEKRHLEREKEELERRLENSSQEIAQLRANQCPQQRSKKVSRWDMESPDYQELKSEMTEVSASSLFSSHSRAGCGELVWVGEPVTLRKAETIAGKYGVWMKDPEPASPYTRETTWRIDTVGTDIRQVFEYDSQGYPSKVHILPRSMESTGAVIYRGSLYFQRRKSRILAKYDLRKETITVQKDLTNAGYHGQFPYSWGGYTDIDLAVDEMGLWAIYSTQKAKGAIVLSTLDPETLEIRQTWETNIRKQSVANSFMICGTLYTISSYSSPDAMIHFAYNTATSTKLLKIHFENRYKYSSMVDYNPTERKLFAWDNFNMVTYDIRLS >XP_015832476.1 PREDICTED: myocilin [Nothobranchius furzeri] MFFLLLCIFGLLLRGDERASLWRGNDRSGQTFTVPSPAEASCPQASA--------------PEVEGLKARLSILEALVSQLSGKDTQSPGSVR--------------GHSELRAVGERNLLQGEKERLEMELEGLRLRMEEMRRETERLRNRPCLPSSSLRDSAWQYGSQGFQELKADVTEVPAP-------DTGCGTLVSVGDPVTHRKADSIAGKYGVWMQDPEAVSPYGPSMVWRIDTIGTDVRQLFGYDDKGFPSKVLLLPDPLESTGATLYRGSLYYQRRLSRSLIRYDLAAEHVAARRELPHAGFHGQFPYSWGGYTDIDLSVDEKGLWAVYSTNKAQGAIVISQLDPQTLEVKKSWETNIRKASVANSFIICGKMYTVASYAAHNTVINYMFDTETSQRAVSIPFKNRYGYNSMVDYSMAQRKLFAWDNFHLVTYDISLG >XP_020727692.1 myocilin [Odocoileus virginianus texanus] MPAVQLLLLACLVGGVRTAQFQKANDQSGRTFRVASPSESSCPEQDQAMSAIQELQRDSRRATLEATKARLSSLEAVLHRLTSGQPTGPLLQKELEALRREREQLETQTRELNLVRDKSALEEEKRQLQAENEDLARRLESSSQEVASLRRGQCPQSGSREVAKWNLENVDFQELKSELTEVPASQILSGHPRTGCGELVWVGEPVTLRTAETITGKYGVWMRDPQAAYPYTRETTWRIDTVGTDIRQVFEYDLQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAKSRTLLRYDLRTETLQAEKEIPGAGYHGQFPYSWGGYTDIDLAVDETGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSKALTIPFKNRYKYSSMIDYNPLERKLFAWDNFNMVTYDIKLS >XP_030289193.1 myocilin [Sparus aurata] MFLLLLCVSGLLLNADERASLWRGNDRAGRTFSVPSPVESSCPQTGG--------------PEMEGLKARLGMLEVLVARLTGGETVAP-GAR--------------AQTELRATGERNLLQGEKERLERELMGLQGRMEEMRKETERLRNRPCPPSSSLRDSAWQYRSPGFQELKAEVTEVPAP-------DTGCGELVSVGEPVTHRKADNIEGKYGVWMQDPEAASIYGPNMIWRIDTIGSDVRKLFGYDDKGFPSKVLLLPEQVESTGATVYRGSLYFQRRLSRTLIRYDLASESVAARRELPHAGFHGQFPYSWGGYTDIDLAVDEQGLWAVYSTSKAKGAIVISKLDPGSLEVKKSWETNIRKSSVANSFIICGKLYTVASYTAPDTIINYMYDTETSQKAVSIPFRNKHRYNSMIDYNRAQRKLFAWDNYHMVSYDIKLG >XP_040216066.1 myocilin [Rana temporaria] MGFFTLNILVPLVFCLGSPQLRRANDRQGQTFTVPSPSEGSCTEPGEAMTSIRELQLENATQETAGLQTRVSLLENMVNKFLGGKATSSPNQKEMETLRMQKDEWEGQRVSLDLLKEKTSLEEDKQRLTERLE----RVQGQCPPVTEVSRNRDQR-GTADLSRWGADGMGYQELKSELTALPASRMISAVESGSCGEITWVGEPTTYRKADNIAGKYGVWMRDPEPVSPFNEETIWRINTVGADIRQVFEYENKGYPTKVYVVPRSMESNGAVIYKSSLYYVRRKSRIIVKYDFKTETVAIQKELSDAGYHGQHPYSWGGYTDIDLAVDELGMWAIYSTDKTKGSIVISQLNPKTLEVNQSWETTIRKHSVANAFMACGTLYTVGSYSSTNTTINFAYDTHTGVKQISVPFKNQYGYGSMVDYNPREKKIYGWDNYNMVSYDVRLS >XP_039269227.1 myocilin-like [Styela clava] MQTLATLLMSPDQYGQTTGQQSSNARQSGRIFTVENADHCTHTTTEIAVNHVARTTLPMQKNILDEYSERLRKLERTVYGETAGQTTSPDMIKQLATLRSEKEDLRKQNKNLNLASSKSELEKHKAKLETVQESFRKRIHVLETEKEQLSRTATHWTAKGELLQQQIE---LEQEKNKILVVNNSQLMNATSRSYCGRITSISMPETVRGPQSIFEKYGVWMTDP--LEAMGKGIVWSIDTTKERAKVLKQYESLNRPQQIIALTIPVESTGGVVYNGSFYYQRRNSRKLVRYDLRTRRVMRERPVHHAGFHGMFAYQWGGFTDIDLAVDEFGLWVIYSTRQNDGNIVVSRLNPVSLRSLMTMKTSIPKRTVANAFMACGILYTVDSYDAANASLNYEFDTFRKKKRISIPFANQHRYNVMIDYNPQTREIYSWDNSHQVKYYVTLD >XP_011677256.1 amassin 4 isoform X1 [Strongylocentrotus purpuratus] MISPALFIVAFRCMSNEYAHVNSSVTENGD--GVTSSLSSSC-GSGVSSAEFQQMIRDLDVCTIVDINVELITLRVTFNQ--QGE-----MHEQMDNINAIKERIIDNKIVIVIRMDLQDMETLISYLEDQNAD-QFIIVKLREEIANISYNLDSLSLLRD----------IADLQQQIAECEADN--IGFPYDSCGTIRGLSEPYTLRGNLA---STGVWFMDPIVDV----DRPW-YQVGVTTASSILRYLSTEGIHETYLPGYTLEGCSVVAYNGALFYNMYGSATIIRYDYREGSVTNQRALPNAGYKTNYVYLSGGYTSMDFAVDEQGLWVIYGKSTNSGLMSVSKIDPLTLEVEETYNTNTLKANFGECFMVCGKLYCTDSFNKHDGRIVMMYDTTTQTTTLNVPFDSKYLATRALKYNPRDQRLYAFNNGHALVYEIEFQ >XP_038073533.1 collagen alpha-1(I) chain-like [Patiria miniata] MTTCALFVFSATCFGVTYVFVASLSAELGQDITVLPPSGSTGPRQAAAASDNQQVRAELGTANIVADKADLRGLNRVRRGFTHGDPQGPAGPKGDTGQRGEKGGLRGSRGDIEAGRDGSNCSCEKQQLTRETVSEACNVTAFLEELMELDNRTLKLGDKGDKGDRGIASGMVELGNAGDDEKPASGKAPSKPQNSECVLTKIGFPVDHKFGNK---YWGSWMQDTAPNPPYP-DKIW--VTKHLVGDGIYEYKNSDSYTQYHRLTGAWAGTGHVVYNNALYFHNGGSGKIVQYDLTLETVTAQATIPEALYQRSNGHRYSDYTYLDLAVDDNGLWVIYKTAENHQNLVVSQLDPENLSVIKTVVSNHPQSSAGDAFIICGRLYTTKSSKNFHSTVDFAVNLFTGEPDVDISYQNGHMKMTMMSYNPRKRLIYAWDKGYMVTYNVTLT >NP_573262.2 uncharacterized protein Dmel_CG6867 [Drosophila melanogaster] LQNTSLILASLSIVFYFQAELMRSEEELRRSTTASSTTQSRDPLKNERKNLISHTTRPTGRRDIASSATEIRKRTGQKGAAPGGDPQGPTGNPGLPGITGPKGGIAGPRGRPVPGINAWKLQYEGRSLNQSSATLECLVEAFPEAIRYWERAYDGKKVYGQVCDQCPDPSLYQCKDSNNFEIQATGNL-----PKTCYLYAVGKPVFHKVVNE---KFGSWLRDPSPDS----DREKTFVTNENDPYNLFEFTTNSIPRRKYEIQEGFHGNAHVVFNGSFYYQQRNSDLVVKLDLTSKKITTQ--LPYAGVAAANRLYTTDYNYMDFNVDEVGLWVIYSTYNSNNTL-VAKLDAETLKMQYNFNITLDHHQFGEMFIVCGNLYAIDSGTDKNTQIRYVVDLYKGKLNTNLPFSNPFSHTTTVGYNPLTVELYSWDKGNALTYPIRYN >NP_491804.2 Olfactomedin-like domain-containing protein [Caenorhabditis elegans] YCNLAITLIAVLAFSHIHYRIWTLESE---ELNFRSKRDIPL-SRGKNASDILWLTSLSSIGELMHKCTEIHEYCSEQDDVRGKPPVGPPGRRGLMGINIGKD---------CPIRDELLMERTIENLE---------------------------PTTPWSVTHQPMPGLVQQILSNYSEVEGCVKIETITTTAHCRLQNVGKPVFHSHSTT---YYGSWMRDAYP--PTGDDARKRYVMNHFQGHELIEFRNRDHVGKVHRLPYIFDGTNHVIFNASLFYQRAGYPIIAKYEFNSKQYS-QFEIPGAAYRGDQYLYNNSMNYFDLAIDENALWVMFHYQE-EAFLSVAKVDINNLTIYEAFNTTVNHTDVANGIVVCGTIYLVESASEQSTYISTAYDFYRNTSQPLIKWINLYKNANMISYNAYDKRIYIYDHGYMLSVPPLLH
PhyML tree of selected proteins ((((tr_Q5F0G5_Q5F0G5_DANRE_Myocilin_OS_Danio_rerio_OX_7955_GN_myoc_PE_2_SV_1:0.24792909,(XP_030289193_1_myocilin__Sparus_aurata_:0.10388897,(XP_015832476_1_PREDICTED__myocilin__Nothobranchius_furzeri_:0.10797009,XP_023809784_1_myocilin__Oryzias_latipes_:0.13730286):0.06313197):0.14461676):0.37699598,(XP_040216066_1_myocilin__Rana_temporaria_:0.24607713,OCT82906_1_hypothetical_protein_XELAEV_18025441mg__Xenopus_laevis_:0.1997679):0.28383741):0.08486752,(((XP_013223602_1_myocilin__Columba_livia_:0.21755639,XP_015145920_3_myocilin__Gallus_gallus_:0.13376731):0.26740511,(XP_014460702_1_PREDICTED__myocilin_isoform_X1__Alligator_mississippiensis_:0.00000001,XP_006017807_1_myocilin_isoform_X1__Alligator_sinensis_:0.0064917):0.20023949):0.058449,(((NP_001041495_2_myocilin_precursor__Canis_lupus_familiaris_:0.0645186,NP_001265779_1_myocilin_precursor__Felis_catus_:0.04997026):0.02411191,((XP_002809846_1_myocilin__Pongo_abelii_:0.01166891,((XP_003824704_1_myocilin__Pan_paniscus_:0.00451599,XP_513995_2_myocilin__Pan_troglodytes_:0.00000001):0.00907806,(sp_Q99972_MYOC_HUMAN_Myocilin_OS_Homo_sapiens_OX_9606_GN_MYOC_PE_1_SV_2:0.00225289,XP_004027946_2_myocilin__Gorilla_gorilla_gorilla_:0.00677751):0.00000001):0.00202149):0.06055261,(NP_001075619_1_myocilin_precursor__Oryctolagus_cuniculus_:0.07355007,(NP_110492_2_myocilin_precursor__Rattus_norvegicus_:0.0356136,NP_034995_3_myocilin_precursor__Mus_musculus_:0.03521035):0.09230595):0.0042588):0.0331289):0.0003661,(NP_999151_1_myocilin_precursor__Sus_scrofa_:0.09072525,((NP_776543_2_myocilin_precursor__Bos_taurus_:0.01702123,(XP_004013742_4_myocilin_isoform_X1__Ovis_aries_:0.00268936,XP_005690701_2_PREDICTED__myocilin_isoform_X1__Capra_hircus_:0.01104132):0.00642554):0.00975789,(XP_020727692_1_myocilin__Odocoileus_virginianus_texanus_:0.01138399,((KAB0377578_1_hypothetical_protein_FD755_012022__Muntiacus_reevesi_:0.00193983,KAB0345677_1_hypothetical_protein_FD754_022603__Muntiacus_muntjak_:0.06076553):0.02089557,(XP_043341789_1_myocilin__Cervus_canadensis_:0.00000001,OWK08457_1_MYOC__Cervus_elaphus_hippelaphus_:0.00250715):0.01417384):0.00288265):0.01975544):0.06167819):0.02628431):0.19721544):0.06029571):0.29803443,XP_039269227_1_myocilin_like__Styela_clava_:1.20252828,(XP_011677256_1_amassin_4_isoform_X1__Strongylocentrotus_purpuratus_:1.76412331,(XP_038073533_1_collagen_alpha_1_I__chain_like__Patiria_miniata_:1.19144754,(NP_491804_2_Olfactomedin_like_domain_containing_protein__Caenorhabditis_elegans_:1.59951625,NP_573262_2_uncharacterized_protein_Dmel_CG6867__Drosophila_melanogaster_:1.24544081):0.40270438):0.54644406):0.32658021);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)