PB0192

DATABASE

Click here to access PB0192 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0192	Q12841	Follistatin-related protein 1	FSTL1	FRP, FSL1, MIR198, OCC-1, OCC1, tsc36, follistatin like 1	Homo_sapiens	Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed:20054002, PubMed:22265692).

Domains

Gene Ontology

PF07648 (Kazal_2) PF09289 (FOLN)

GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008201 (enables) heparin binding GO:0030154 (involved in) cell differentiation GO:0030510 (involved in) regulation of BMP signaling pathway GO:0043066 (involved in) negative regulation of apoptotic process GO:0043542 (involved in) endothelial cell migration GO:0045446 (involved in) endothelial cell differentiation GO:0061484 (involved in) hematopoietic stem cell homeostasis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005788 (located in) endoplasmic reticulum lumen GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q12841|FSTL1_HUMAN Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1 MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKP HKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDE LRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAIN ITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETY ADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKT KRVSTKEI >sp|Q12841-2|FSTL1_HUMAN Isoform 2 of Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 MWKRWLALALALVAVAWVRAEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYD GHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKN FDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSF QEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGA QTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI >tr|Q2PMI2|Q2PMI2_DANRE Follistatin-like 1b OS=Danio rerio OX=7955 GN=fstl1b PE=1 SV=1 MMFRCLPVFFLLAVVCCHAEQEAQSKSKVCANVFCGAGRECAVNEKGEPSCLCIEQCKTH KRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKKEKAAASPVVCYVADRNEL RRRVIEWLQTEVVPDGWFTKGSNFTDILLKYFKNYDNGDSQLDSAELLKFIQHNETAVQM SSYAEEENNRLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFSPPEKKCALEDETYE DGAETQVECNRCVCACGNWVCTAMTCDEKTPVFDTEGDQEMTEEEWTRRVAELNKHQETV EKMKTSTKEV
Selected proteins from model organisms >sp|Q12841|FSTL1_HUMAN Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1 MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKP HKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDE LRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAIN ITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETY ADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEEMTRYVQELQKHQETAEKT KRVSTKEI >sp|Q12841-2|FSTL1_HUMAN Isoform 2 of Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 MWKRWLALALALVAVAWVRAEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYD GHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKN FDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSF QEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGA QTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI >tr|Q2PMI2|Q2PMI2_DANRE Follistatin-like 1b OS=Danio rerio OX=7955 GN=fstl1b PE=1 SV=1 MMFRCLPVFFLLAVVCCHAEQEAQSKSKVCANVFCGAGRECAVNEKGEPSCLCIEQCKTH KRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKKEKAAASPVVCYVADRNEL RRRVIEWLQTEVVPDGWFTKGSNFTDILLKYFKNYDNGDSQLDSAELLKFIQHNETAVQM SSYAEEENNRLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFSPPEKKCALEDETYE DGAETQVECNRCVCACGNWVCTAMTCDEKTPVFDTEGDQEMTEEEWTRRVAELNKHQETV EKMKTSTKEV >NP_032073.2 follistatin-related protein 1 precursor [Mus musculus] MWKRWLALSLVTIALVHGEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKT YLNHCELHRDACLTGSKIQVDYDGHCKEKKSASPSASPVVCYQANRDELRRRLIQWLEAEIIPDGWFSKG SNYSEILDKYFKSFDNGDSHLDSSEFLKFVEQNETAINITTYADQENNKLLRSLCVDALIELSDENADWK LSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTHTEEE KTGYVQELQKHQGTAEKTKKVNTKEI >NP_077345.1 follistatin-related protein 1 precursor [Rattus norvegicus] MWKRWLALALVTIALVHGEEEQRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKT YLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQANRDELRRRIIQWLEAEIIPDGWFSKG SNYSEILDKYFKSFDNGDSHLDSSEFLKFVEQNETAVNITAYPNQENNKLLRGLCVDALIELSDENADWK LSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTCDGKNQKGVQTHTEEE MTRYAQELQKHQGTAEKTKKVNTKEI >NP_989969.2 follistatin-related protein 1 precursor [Gallus gallus] MIWKTLPLLCALLAVARLRAEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNG KTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSENPAASPVVCYQSDRDELRRRVIQWLEAEIIPDGWFS KGSNYSDVLDKYFKNFDDDSRLDSTEFLKFVEQNETAVPTITTYVDQETNKLLRGLCVDALIELSDENAD WKLSFNEFLKCLSPSFNPPEKKCALEDETYEDGAETQVECNRCVCACGNWVCTAMTCEGKNEKMTAHRQQ PGQDLTEEELARYVQELQKHQETAEKTKKMSTKEM >NP_001017950.1 follistatin-related protein 1 precursor [Bos taurus] MMWRRWLALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEE EMTRYVQELQKHQETAEKSKRVSTKEI >XP_038301004.1 follistatin-related protein 1 [Canis lupus familiaris] MWTRWLALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKT YLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKG SNYSEILDKYFKNVDNGDSRLDSSELLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWK LSFQEFLKCLNPTFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGTQTQTEEE MTRYVQELQKHQETAEKTKKMSTKEI >NP_001231517.2 follistatin-related protein 1 precursor [Pan troglodytes] MWKRWLALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKT YLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKG SNYSEILDNYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWK LSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEEE MTRYVQELQKHQETAEKTKRVSTKEI >NP_001125838.1 follistatin-related protein 1 precursor [Pongo abelii] MMWKRWLALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSR GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTEE EMTRYVQELQKHQETAEKTKRVSTKEI >XP_008265088.1 PREDICTED: follistatin-related protein 1 [Oryctolagus cuniculus] MMWKRWLALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKPVSPSASPVVCYQANRDELRRRIIQWLEAEIIPDGWFSK GSNYSEVLDKYFKNFDDGDSRLDSSEFLKFVEQNETAINITTYADKENNKLLRGLCVDALIELSDENADW KLSFQEFLTCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKHQKGPQVQEEE EMTRYIQELQKHQETAEKTKRVSTKEI >XP_003991726.1 follistatin-related protein 1 [Felis catus] MMWTRWLALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNVDNGDSRLDSSELLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPTFNPPERKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQAQTEE EMTRYVQELQKHQETAEKTKKVSTKEI >XP_014947951.1 follistatin-related protein 1 [Ovis aries] MMWRRWLALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYTDQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEE EMTRYVQELQKHQETAEKSKRVSTKEI >XP_004082017.1 follistatin-related protein 1 [Oryzias latipes] MLRSVAVLLALAAALCSAEEQQQSKSKVCANVFCGAGRECAVTEKGEPSCLCIESCKPHKRSVCGSNGKT YRNHCELHRDACLTGLKIQVAHDGHCKEKKAEKAAANPVVCYAADRNELRHRLIQWLQTEIVPDGWFVKG SNFSEILLKYFKIYDNGDSQLDSSELLKFIQHNDSVVKLQSYADQESNKLLRSLCVDALIELSDENADWK LSFDEFLNCLKPDFNPPEKKCALEDETFEDGAETQVECNRCVCACGNWVCTAMICTDKHVAAGESADVGA EMTEEEWNLRVAELNKHQDTMEKMKTSTKEI >XP_021143523.1 follistatin-related protein 1 [Columba livia] MCLVSQAWLSAEKKKRYQESFGKGDSDCELYRECSSSRHCVQMAVRSPGLQLTEIPQQWKLQGMDESRRE TRSVLQRKEDVGEEEQGCEDELYYIEVAAATPAYSHDSNRWSFIKRKHDEVQGLLLCILQEEPRSKSKIC ANVFCGAGRECTVTEKGEPTCLCIEKCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEK KSENPAASPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKGSNYSEVLDKYFKSFDNGDSRLDSTEFLEF VEQNETAVNITTYMDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCLSPSFNPPEKKCALEDENYE DGAETQVECNRCVCACGNWVCTAMTCEGKNEKVPAQRQRPDQDLTEEELARYVQELQKHQETAEKTKRMS TKEM >XP_017898955.1 PREDICTED: follistatin-related protein 1 isoform X1 [Capra hircus] MMWRRWLALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYTDQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEE EMTRYVQELQKHQETAEKSKRVSTKEI >XP_014379598.1 follistatin-related protein 1 [Alligator sinensis] MAEEPKSKSKVCANVFCGAGRECAVTEKGEPTCLCIEQCKAHKRPVCGSNGKTYLNHCELHRDACLTGSK IQVDYDGHCKEKKAENPAASPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKGSNYSEVLDKYFKSFDDG DSRLDSSEFLKFVEQNETAINITTYMDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCLSPSFNPP EKKCALEDETYEDGAETQVECNSCVCACGNWVCTAMTCDGKNGKVSPRGQQRHEDLTEEELARYVQELQK HQETAEKTKRMSTKEM >XP_019331592.1 PREDICTED: follistatin-related protein 1 [Alligator mississippiensis] MWTPVLCLALVLAAARLRAEEEPKSKSKVCANVFCGAGRECAVTEKGEPTCLCIEQCKAHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKAENPAASPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSK GSNYSEVLDKYFKXXXDGDSRLDSSEFLKFVEQNETAINITTYMDQETNKLLRGLCVDALIELSDENADW KLSFNEFLKCLTYPDFLLVFIGKNGKVSPRGQQRHEDLTEEELARYVQELQKHQETAEKTKRMSTKEM >XP_020767089.1 follistatin-related protein 1 isoform X1 [Odocoileus virginianus texanus] MMWRRWLALALVTVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQAEE EMTRYVQELQKHQETAEKSKRVSTKEI >XP_015821769.1 PREDICTED: follistatin-related protein 1 [Nothobranchius furzeri] MWRSVPALLLVALAVSNAEELKSKSKVCANVFCGAGRECAVSEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHRDA CLTGLKIQVAHDGHCREKKTGQAAASPVVCYAADRNELRSRVIQWLQTEVIPDGWFVKGSNFSEILLKYFKSYANSDSQL DSSELLNFIQHNDSVVELHSYADQESNRLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFNPPEKKCALEDELYEDG AETQVECNRCVCACGNWVCTAMTCSGKDKHGAVDESADPGAEMTEEEWNLRVAELNKHQETVEKMKVSTKEV >NP_001081432.1 follistatin-related protein precursor [Xenopus laevis] MYLRCVPLLALLVLCSALEEPKSKSKVCANVFCGAGRECAVTEKGDPTCLCIEKCKSHKRPVCGSNGKTYLNHCELHRDA CLTGSKIQVDYDGHCKEKTSDTPAAVPVACYQSDRDEMRRRVIHWLQTEIIPDGWFSKGSDYSEILDRYFKKFDDGDSHL DSAELQSFLEQSQSTNITTYKDEETNRMLKSLCVEALIELSDENADWKLNKNEFLKCLNPDFQPSEKKCALEDETYEDGA ETQVQCNRCVCACGNWVCTAMACEGKDGDHGEDMGRYVEEIRKQQETIENSKSSSDKDA >XP_030284009.1 follistatin-related protein 1 [Sparus aurata] MMLSRSVAALLLLAAAVCNAQEQQSKSKVCANVFCGAGRECAVNEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHR DACLTGLKIQVAHDGHCQEKKSEQAAASPVVCYAADRNELRSRVIQWLQTEVIPDGWFVKGSNFSDILHKYFKSYDNGDS QLDSSELLKFIQQNESVVELQSYADQESNKLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFNPPEKKCALEDETYE DGAETQVECNRCVCACGNWVCTAMTCTDKTAAVDESTDAGAEMTEEEWNLRVAELNKHQETVEKMKSSTKEA >XP_020925965.1 follistatin-related protein 1 isoform X1 [Sus scrofa] MMWTRWLALALVAVAWVHAEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADW KLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGTQTQTEE EMTRYVQELQKHQETAEKTKRVSTKEI >XP_034813056.1 follistatin-related protein 1 [Pan paniscus] MWKRWLALALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNG KTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFS KGSNYSEILDKYFKNFDNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENAD WKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTCDGKNQKGAQTQTE EEMTRYVQELQKHQETAEKTKRVSTKEI >XP_040195136.1 follistatin-related protein 1 [Rana temporaria] MILRCSPLLLLLAASLCRAQEEPKSKSKVCANVFCGAGRECAVTEKGDPTCLCIEKCKSHKRPVCGSNGK TYLNHCELHRDACLTGSKIQVDHDGHCKEKTSEAPAATPVVCYQTDRDELRRRIIQWLEAEIIPDGWFSK GSNYSEILNRYFKNYDDGDSRLDSTEFLKFLELNQTAINITTYQDQETNKILKGLCVEALIELSDENADW KLSFNEFLKCLNPGFNPPEKKCALEDETYEDGAETQVQCNRCVCACGNWVCTAMSCDDKDGHPEGDMSRY VDELRKHQETIEKSKQAGSKDI >XP_031569839.1 follistatin-related protein 1-like [Actinia tenebrosa] MLRIIILLCAVLLPATLYARTVKPSEEKEDNDHCANVFCHAGQECIIEEGNATCQCIIRCPDHKKTVCGSDGITYPSHCE LHRTACVQGKKIAIENNGPCADIYPTQPPTGKVHKSKPVVCYEHNRDDLRNRLIVWLRFLDQAVDESAGDHHIFKKYFDA MDVDKNAKLSRKEFAQLIKFNNTVGQMPGADKFINPVLQGLCADALIAVSDEDADWELTFHEFMKCLNPAVKPPKERCEL EGEYFDDGAEIPAECNTCVCACGHWVCTALNCNSEKAKSDNDFVVKGDKAKQKLKEVHRNEKGDKEKVLMLYKPKQQKQR SERKEQ >XP_038065021.1 follistatin-related protein 1-like isoform X3 [Patiria miniata] MALKLTSLLIITLVLTSCEVLTKTGKANRGRHIKKEWRGERKATEADSKSLPSQADVCAGVECGVGKECTLTTDGEASCV CVQECRRHRSRLLCASDGVTYTNECELQRAACRGGIQLFIEHEGVCAHPTPTSSPASRTHPIACYQDQRDTLQREIVEWL QGVRASAGPGDNAYEALLEDYFARFDDTQDNFLEPTEFLKFVEHNETLQKTTDDLNQYYEEDTLLRSLCVDALLAEADEN FDWRLSLSEFKKVMMPGFNPPTKLCSLEGKYFMDGQEKKNKCNICICACGNWVCTANACDGRFIAGERAMGENTEETVSK DTWLNIMKKLSSVDPVKFPTDSHNVSQLAAKVIGREETVIETSTEEAR >XP_030835975.1 follistatin-related protein 5 [Strongylocentrotus purpuratus] MRILSVGVLIAMVLTCSVEARPKRHRSHHHTKKASLDAWHVNDVFPDPNTDACSHVECPKGSECLVNRTTNLAECICRPY CKPHYKPVCGSDGVMYENHCELHRASCVSGQRITVHSHGCDTPQTAFVMTTTPEGPIPSMSPTEAPDTCTPEEMAQLKEE LIAHYREQFHNPNEDNDLPPLNKKYIVSLILNHYDIDADDAISRQEMESAMTLDRITDLLPGCSFLDVLDSGDFDGNEKL SGMELYREFNIKAVSLSGSIAQRVTVAKVGDNLALPCELSSDHPLEIRWTRNNAPLTEIQEYQGIGFYAGDTSLYLTAIT LMHEGSYACYAEGYEEVKQTHLLQVQVPPSVKICPHSQLRKQGSKARVQCHAEGIPTPQKSWTRNDIPLVQSDRIEMQNK NSSVLVKEISYPDTGIYTCTATNPLSEAHQSASVFIQPQDHPLSPGPLHVFYLFHRDGIQTFEPDTCGFRLALTGASTLP DTIKTLCSVDQVSETRRCDWGDAVSVDDRYIYASQPYENRVVVLDARSQRIIEVISTDGQPVSLQYVEHVDSLWVLCRRS EEEAKAGRQSIMVIKSAGQPGPHHTIHTEPVGHTFELVEGLFIPREQIPKQGTMNFGYIVHHNQLGLHKIDLVRMERVAL IDLTAYNCHPEALNFVAIGGSVVINCAGSETVPAKQLVLDYLTDSVIKVNEGIRGRPYVSPDGRYIISVDANHQYVHVQK VLSESGKIKTAFEVKTNLRISDVGFFPSKTSHTYDVFATSRDQPDVLFIDLESGFVKTITGVQTPIDDEDWPWDSRNRRI VNSGFFDPYLVTPAANHEIVINGLLRKVHCDIEDIAVANVIVWIGKC >NP_001027532.1 follistatin-like 5 [Apis mellifera] MRCMLEIAARSFLLLSIASTYVVSVAGYKHSRRHRDFTVAESYDASSSNSDSLSMTIPPSIDRSSIHEESYLAESSRSID PCASKYCGIGKECELSPNSTIAVCVCMRKCPRRHRPVCASNGKIYANHCELHRAACHSGSSLTKSRLMRCLHHDIENAHI RRTLHMNRTSLKTSKIVSYPKSRSRKKGGLKDNLIPDKNDPDSKECSNQEYEIMKDNLLLYNHARLMSQDNHSKEYLVSI MFSHYDRNNNGNLEREELEQFAENEDLEELCRGCNLGHMISYDDTDGDGKLNVNEFYMAFSKLYSVSVVSLDKSLEVNHI SARVGDNVEIKCDVTGTPPPPLVWRRNGADLETLNEPEIRVFNDGSLYLTKVQLIHAGNYTCHAVRNQDVVQTHVLTIHT IPEVKVTPRFQAKRLKEEANIRCHVAGEPLPRVQWLKNDEALNHDQPDKYDLIGNGTKLIIKNVDYADTGAYMCQASSIG GITRDISSLVVQEQPTPTTESEERRFFSFHQWGILVYEPSACRPRHEIRSTDVIPGTQEHVCGVKGIPCSWGRAINVANR YVYASQPDKDRVLVISEIQMVIVDVIPTDKNPVQLWYVPSLDQVWILNWRNQKDIDVKTVQVIEDAAQKKKHRAIRPEPI DAQFDIIQNIYIPEPQDIENIFKYGYVSHANQRNMYKLDLKNMKYTRSADLSSYNCVPINVQFSVLYGFVIIECQEPVTN RPTGQLLLDYLTDTVLAYKPKILGKPTISPDSRHLVTLDKQETGVTLVVQEISSDGLKFAFDVKTTLNISDIALYPSQTT HGYDIYASSIDKENILFLDLSTGKVEMITGVGKATSPNLTKWGNPNRPIVQSGIFGKYMVSPSNDALFVLNGETRTINCE IGGLQHPGAVVWFTVSLH >XP_039272924.1 follistatin-related protein 5-like isoform X2 [Styela clava] MQNAVFVVLWVVSLSMVIARPEKNTQSFDTNAPDPNEIISQLPESLDTVHSDGKIQDDITSRRKNIVHKKRYNDANLSIE LFRETLSHHVGNAESKTDRCRYMRCQPGEECLVEDERAKCVCKRHCKARHHPICGTDGEYYENHCEMHRQACLSVRDIYD ARHKDCFYKASECSGWELKQYQEMMMQFYRNVMTSAKLRHNEGKDGKVQTKLNRSKRSTKKERTAERKTHRRGGLDIIPG EAGDPETNKIVPPITEELDVSPSPKSRLQNDVSTSPSDTPPDQIPSAKQVVIKDSYEFLNVIQSKINLSNEYEEIMTKDS AGDMVKYIFALMDLDSNGNVGSDEIWEITSLQHLDNVLPGPCSLFHILKYGDTNLDRTLDISETFELFNISVYRLQNQKR YVHRPATYGNPMQLECGIEGESSPVWYRYGRKVQEKNGAKVLGRTLYISDVTSKNAGNYTCSTKKKESITQTINLQIMVA PKVEIHPRTQHPSLQSSATVKCHAEGLPRPRITWKRNGESLDLKSGRYILMANNTELHFNSVEEQDSAAYSCTAENAAGV GEDVGAIYVQTDDVHESESEASSAYFVFHEHGISIMDPHSCQLVRSIQNTERVPGLLSQDKLCDLVDDETRQCMWSDSIE VGYRFIYVAQPTEDRIIVVDKQLQRVVEVITTDLMPVELYYVKSTDQVFVVCWADSLRTGSLIQVIHRAAVTGTHFAEHV KPVAISGHRTYDRAIHSLYIPPETPLNPNSEYGYILHKNEAAIHRLNLATLTYSNPIDLSPYGCIPLRLNYLPIGGLLYI TCESEEDGKTIHEIAIDIETDVEVIFKKNTGVAQEFFSYDYSFAIKLRPGHDMITLHNISNGGEMHEFMMIRTNFQVADT YFARKKYNPESMVAYMVAKNQGDIMYVDLEKKKVEIINGMTTPAPEHAWPWRERSRKMTPSGWFGWFLATAGRTGMEILG MNSNQVLCRMDQFVRVTAVSWSGGEF
Mafft alignment of selected proteins >sp|Q12841|FSTL1_HUMAN Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1 ---------------------------------------------------------MWK -------------RWL---------------ALALALVAVA------------------- ------WVRAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >sp|Q12841-2|FSTL1_HUMAN Isoform 2 of Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 ---------------------------------------------------------MWK -------------RWL---------------ALALALVAVA------------------- ------WVRA-------------------------------------------------- ------------------------------------------------------------ -----EQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >tr|Q2PMI2|Q2PMI2_DANRE Follistatin-like 1b OS=Danio rerio OX=7955 GN=fstl1b PE=1 SV=1 --------------------------------------------------------MMFR -------------CL-----------------PVFFLLAVV------------------- ------CCHAEQEA---------------------------------------------- ---------------------------------QSKSKVCANVFCGAGRECAVNEKGE-P SCLCIEQCKTHK-RSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKKEKA--- ------------------------------------------AAS--------------- --------------PVVCYVADRNELRRRV----IEWLQTEVVPDGWFTK---------- -------------------GSN-FT---------DILLKYFKNYD-NG-DSQLDSAELLK FIQHNETAV-QMSSYAEE--ENNRLLRS-LCVDALIELSDENADWKLSFDEFLNCL---- KPGFSPPEKKCALEDETYEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--EKTPVFDT----------------------------------- -----EGD---------------------------------------------------- ------------QEMTEEEWTRRVAELNKHQETVEKMKT-STKEV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_032073.2 follistatin-related protein 1 precursor [Mus musculus] ---------------------------------------------------------MWK -------------RW-----------------LALSLVTIA------------------- ------LVHGEEEP---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSASP--- ------------------------------------------SAS--------------- --------------PVVCYQANRDELRRRL----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKSFD-NG-DSHLDSSEFLK FVEQNETAI-NITTYADQ--ENNKLLRS-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCSCGHWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GVQTHTEEEKTGYVQELQKHQGTAEKTKKVNTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_077345.1 follistatin-related protein 1 precursor [Rattus norvegicus] ---------------------------------------------------------MWK -------------RW-----------------LALALVTIA------------------- ------LVHGEEEQ---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQANRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKSFD-NG-DSHLDSSEFLK FVEQNETAV-NITAYPNQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCSCGHWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GVQTHTEEEMTRYAQELQKHQGTAEKTKKVNTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_989969.2 follistatin-related protein 1 precursor [Gallus gallus] --------------------------------------------------------MIWK -------------TL----------------PLLCALLAVA------------------- ------RLRAEEEP---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSENP--- ------------------------------------------AAS--------------- --------------PVVCYQSDRDELRRRV----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------DVLDKYFKNFD-D--DSRLDSTEFLK FVEQNETAVPTITTYVDQ--ETNKLLRG-LCVDALIELSDENADWKLSFNEFLKCL---- SPSFNPPEKKCALEDETYEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CE--GKNEKMTA----------------------------------- -----HRQQ--------------------------------------------------- ----------PGQDLTEEELARYVQELQKHQETAEKTKKMSTKEM--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001017950.1 follistatin-related protein 1 precursor [Bos taurus] --------------------------------------------------------MMWR -------------RW-----------------LALALVAVA------------------- ------WVHAEEQV---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYADQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_038301004.1 follistatin-related protein 1 [Canis lupus familiaris] ---------------------------------------------------------MWT -------------RW-----------------LALALVAVA------------------- ------WVHAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNVD-NG-DSRLDSSELLK FVEQNETAI-NITTYADQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPTFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GTQTQTEEEMTRYVQELQKHQETAEKTKKMSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001231517.2 follistatin-related protein 1 precursor [Pan troglodytes] ---------------------------------------------------------MWK -------------RW-----------------LALALVAVA------------------- ------WVRAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDNYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001125838.1 follistatin-related protein 1 precursor [Pongo abelii] --------------------------------------------------------MMWK -------------RW-----------------LALALVAVA------------------- ------WVRAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSR---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_008265088.1 PREDICTED: follistatin-related protein 1 [Oryctolagus cuniculus] --------------------------------------------------------MMWK -------------RW-----------------LALALVAVA------------------- ------WVHAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKPVSP--- ------------------------------------------SAS--------------- --------------PVVCYQANRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EVLDKYFKNFD-DG-DSRLDSSEFLK FVEQNETAI-NITTYADK--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLTCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKHQK-------------------------------------- ------------------------------------------------------------ ----------GPQVQEEEEMTRYIQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_003991726.1 follistatin-related protein 1 [Felis catus] --------------------------------------------------------MMWT -------------RW-----------------LALALVAVA------------------- ------WVHAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNVD-NG-DSRLDSSELLK FVEQNETAI-NITTYADQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPTFNPPERKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQAQTEEEMTRYVQELQKHQETAEKTKKVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_014947951.1 follistatin-related protein 1 [Ovis aries] --------------------------------------------------------MMWR -------------RW-----------------LALALVAVA------------------- ------WVHAEEQV---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYTDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_004082017.1 follistatin-related protein 1 [Oryzias latipes] ---------------------------------------------------------MLR -------------SV-----------------AVLLALAAA------------------- ------LCSAEEQQ---------------------------------------------- ---------------------------------QSKSKVCANVFCGAGRECAVTEKGE-P SCLCIESCKPHK-RSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKAEKA--- ------------------------------------------AAN--------------- --------------PVVCYAADRNELRHRL----IQWLQTEIVPDGWFVK---------- -------------------GSN-FS---------EILLKYFKIYD-NG-DSQLDSSELLK FIQHNDSVV-KLQSYADQ--ESNKLLRS-LCVDALIELSDENADWKLSFDEFLNCL---- KPDFNPPEKKCALEDETFEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMI------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CT--DKHVAAGE----------------------------------- -----SAD---------------------------------------------------- ----------VGAEMTEEEWNLRVAELNKHQDTMEKMKT-STKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_021143523.1 follistatin-related protein 1 [Columba livia] MCLVSQAWLSAEKKKRYQESFGKGDSDCELYRECSSSRHCVQMAVRSPGLQLTEIPQQWK LQG-MDESRRETRSVLQRKEDVGEEEQGCEDELYYIEVAAATPAYSHDSNRWSFIKRKHD EVQGLLLCILQEEP---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECTVTEKGE-P TCLCIEKCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSENP--- ------------------------------------------AAS--------------- --------------PVVCYQSDRDELRRRV----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EVLDKYFKSFD-NG-DSRLDSTEFLE FVEQNETAV-NITTYMDQ--ETNKLLRG-LCVDALIELSDENADWKLSFNEFLKCL---- SPSFNPPEKKCALEDENYEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CE--GKNEKVPA----------------------------------- -----QRQR--------------------------------------------------- ----------PDQDLTEEELARYVQELQKHQETAEKTKRMSTKEM--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_017898955.1 PREDICTED: follistatin-related protein 1 isoform X1 [Capra hircus] --------------------------------------------------------MMWR -------------RW-----------------LALALVAVA------------------- ------WVHAEEQV---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYTDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_014379598.1 follistatin-related protein 1 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ---------MAEEP---------------------------------------------- ---------------------------------KSKSKVCANVFCGAGRECAVTEKGE-P TCLCIEQCKAHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKAENP--- ------------------------------------------AAS--------------- --------------PVVCYQSDRDELRRRV----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EVLDKYFKSFD-DG-DSRLDSSEFLK FVEQNETAI-NITTYMDQ--ETNKLLRG-LCVDALIELSDENADWKLSFNEFLKCL---- SPSFNPPEKKCALEDETYEDGAETQVECN------------------------------- ---------SCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNGKVSP----------------------------------- -----RGQQ--------------------------------------------------- ----------RHEDLTEEELARYVQELQKHQETAEKTKRMSTKEM--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_019331592.1 PREDICTED: follistatin-related protein 1 [Alligator mississippiensis] ---------------------------------------------------------MWT -------------PV----------------LCLALVLAAA------------------- ------RLRAEEEP---------------------------------------------- ---------------------------------KSKSKVCANVFCGAGRECAVTEKGE-P TCLCIEQCKAHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKAENP--- ------------------------------------------AAS--------------- --------------PVVCYQSDRDELRRRV----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EVLDKYFKXXX-DG-DSRLDSSEFLK FVEQNETAI-NITTYMDQ--ETNKLLRG-LCVDALIELSDENADWKLSFNEFLKCL---- ----------------TYPDFLLVFIGKN------------------------------- ---------GKVSPRG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------QQ--------------------------------------------------- ----------RHEDLTEEELARYVQELQKHQETAEKTKRMSTKEM--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_020767089.1 follistatin-related protein 1 isoform X1 [Odocoileus virginianus texanus] --------------------------------------------------------MMWR -------------RW-----------------LALALVTVA------------------- ------WVHAEEQV---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYADQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQAEEEMTRYVQELQKHQETAEKSKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_015821769.1 PREDICTED: follistatin-related protein 1 [Nothobranchius furzeri] ---------------------------------------------------------MWR -------------SV-----------------PALLLVALA------------------- ------VSNAEE-L---------------------------------------------- ---------------------------------KSKSKVCANVFCGAGRECAVSEKGE-P SCLCIESCKPHK-RSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCREKKTGQA--- ------------------------------------------AAS--------------- --------------PVVCYAADRNELRSRV----IQWLQTEVIPDGWFVK---------- -------------------GSN-FS---------EILLKYFKSYA-NS-DSQLDSSELLN FIQHNDSVV-ELHSYADQ--ESNRLLRS-LCVDALIELSDENADWKLSFDEFLNCL---- KPGFNPPEKKCALEDELYEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CSGKDKHGAVDE----------------------------------- -----SAD---------------------------------------------------- ----------PGAEMTEEEWNLRVAELNKHQETVEKMKV-STKEV--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >NP_001081432.1 follistatin-related protein precursor [Xenopus laevis] --------------------------------------------------------MYLR -------------CV-----------------PLLALL--V------------------- ------LCSALEEP---------------------------------------------- ---------------------------------KSKSKVCANVFCGAGRECAVTEKGD-P TCLCIEKCKSHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKTSDTP--- ------------------------------------------AAV--------------- --------------PVACYQSDRDEMRRRV----IHWLQTEIIPDGWFSK---------- -------------------GSD-YS---------EILDRYFKKFD-DG-DSHLDSAELQS FLEQSQST--NITTYKDE--ETNRMLKS-LCVEALIELSDENADWKLNKNEFLKCL---- NPDFQPSEKKCALEDETYEDGAETQVQCN------------------------------- ---------RCVCACGNWVCTAMA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CE--GKDGD-------------------------------------- ------------------------------------------------------------ ---------------HGEDMGRYVEEIRKQQETIENSKSSSDKDA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_030284009.1 follistatin-related protein 1 [Sparus aurata] M-------------------------------------------------------MLSR -------------SV-----------------AALLLLAAA------------------- ------VCNAQE-Q---------------------------------------------- ---------------------------------QSKSKVCANVFCGAGRECAVNEKGE-P SCLCIESCKPHK-RSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCQEKKSEQA--- ------------------------------------------AAS--------------- --------------PVVCYAADRNELRSRV----IQWLQTEVIPDGWFVK---------- -------------------GSN-FS---------DILHKYFKSYD-NG-DSQLDSSELLK FIQQNESVV-ELQSYADQ--ESNKLLRS-LCVDALIELSDENADWKLSFDEFLNCL---- KPGFNPPEKKCALEDETYEDGAETQVECN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CT--DKTAAVDE----------------------------------- -----STD---------------------------------------------------- ----------AGAEMTEEEWNLRVAELNKHQETVEKMKS-STKEA--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_020925965.1 follistatin-related protein 1 isoform X1 [Sus scrofa] --------------------------------------------------------MMWT -------------RW-----------------LALALVAVA------------------- ------WVHAEEEP---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GTQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_034813056.1 follistatin-related protein 1 [Pan paniscus] ---------------------------------------------------------MWK -------------RWL---------------ALALALVAVA------------------- ------WVRAEEEL---------------------------------------------- ---------------------------------RSKSKICANVFCGAGRECAVTEKGE-P TCLCIEQCKPHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSP--- ------------------------------------------SAS--------------- --------------PVVCYQSNRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILDKYFKNFD-NG-DSRLDSSEFLK FVEQNETAI-NITTYPDQ--ENNKLLRG-LCVDALIELSDENADWKLSFQEFLKCL---- NPSFNPPEKKCALEDETYADGAETEVDCN------------------------------- ---------RCVCACGNWVCTAMT------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GKNQK-------------------------------------- ------------------------------------------------------------ ----------GAQTQTEEEMTRYVQELQKHQETAEKTKRVSTKEI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_040195136.1 follistatin-related protein 1 [Rana temporaria] --------------------------------------------------------MILR -------------CS-----------------PLLLLLAAS------------------- ------LCRAQEEP---------------------------------------------- ---------------------------------KSKSKVCANVFCGAGRECAVTEKGD-P TCLCIEKCKSHK-RPVCGSNGKTYLNHCELHRDACLTGSKIQVDHDGHCKEKTSEAP--- ------------------------------------------AAT--------------- --------------PVVCYQTDRDELRRRI----IQWLEAEIIPDGWFSK---------- -------------------GSN-YS---------EILNRYFKNYD-DG-DSRLDSTEFLK FLELNQTAI-NITTYQDQ--ETNKILKG-LCVEALIELSDENADWKLSFNEFLKCL---- NPGFNPPEKKCALEDETYEDGAETQVQCN------------------------------- ---------RCVCACGNWVCTAMS------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--DKDGH-------------------------------------- ------------------------------------------------------------ ---------------PEGDMSRYVDELRKHQETIEKSKQAGSKDI--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_031569839.1 follistatin-related protein 1-like [Actinia tenebrosa] ---------------------------------------------------------MLR --------IIILLCA-----------------VLLPATLYA------------------- ------RTVKPSEE---------------------------------------------- ---------------------------------KEDNDHCANVFCHAGQEC-IIEEGN-A TCQCIIRCPDHK-KTVCGSDGITYPSHCELHRTACVQGKKIAIENNGPCADIYPTQP--- ------------------------------------PTGKVHKSK--------------- --------------PVVCYEHNRDDLRNRL----IVWLR---FLDQAVDE---------- -------------------SAG-DH---------HIFKKYFDAMDVDK-NAKLSRKEFAQ LIKFNNTVG-QMP-GADK--FINPVLQG-LCADALIAVSDEDADWELTFHEFMKCL---- NPAVKPPKERCELEGEYFDDGAEIPAECN------------------------------- ---------TCVCACGHWVCTALN------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CN--SEKAKSDNDFVV------------------------------- -----KGDK--------------------------------------------------- ------AKQ-KLKEVHRNEKGDKEKVLMLYKPKQQKQRS-ERKEQ--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------- >XP_038065021.1 follistatin-related protein 1-like isoform X3 [Patiria miniata] --------------------------------------------------------MALK LTSLLIITLVLTSCE-----------------VLTKTGKAN------------------- ------RGRHIKKEWR---------GERKATEADS------------------------- ------------------------------KSLPSQADVCAGVECGVGKECTLTTDGE-A SCVCVQECRRHRSRLLCASDGVTYTNECELQRAACRGGIQLFIEHEGVCAHPTPTSS--- ------------------------------------------PASRT------------- -------------HPIACYQDQRDTLQREI----VEWLQGVRASAG---P---------- -------------------GDNAYE---------ALLEDYFARFD-DTQDNFLEPTEFLK FVEHNETLQ-KTTDDLNQYYEEDTLLRS-LCVDALLAEADENFDWRLSLSEFKKVM---- MPGFNPPTKLCSLEGKYFMDGQEKKNKCN------------------------------- ---------ICICACGNWVCTANA------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------CD--GRFIA-------------------------------------- ------------------------------------------------------------ ---------------GERAMGENTEETVSKDTWLNIMKKLSSVDPVKF------------ ----------PTDSHNVSQLAAKV-------------IGRE------------------- ------------------ETVIETS---------TEEAR--------------------- ------------------------------------------------------------ -------------- >XP_030835975.1 follistatin-related protein 5 [Strongylocentrotus purpuratus] ----------------------------------------------------------MR ----------ILS-------------------VGVLIAMVL------------------- ------TCSVEARPKRHRSHHHTKKASLDAWHVND------------------------- ------------------------------VFPDPNTDACSHVECPKGSECLVNRTTNLA ECICRPYCKPHY-KPVCGSDGVMYENHCELHRASCVSGQRITVHSHG-C----------- ----------------------------------------DTPQTAFVMTTTPE------ ---GPIPSMSPTEAPDTCTPEEMAQLKEEL----IAHYREQFHNPNEDNDLPP------- -------------------LNKKY-----------IVSLILNHYDIDA-DDAISRQEMES AMTLD---------------RITDLLPG-CSFLDVLDSGDFDGNEKLSGMELYREF---- NIKAVSLSGSIAQRVTVAKVGDNLALPCELSSDHPLEIRWTRNNAPLTEIQEYQGIGFYA GDTSLYLTAITLMHEGSYACYAEGYEEVKQTHLLQVQVPPSVKICPHSQLRKQGSKARVQ CHAEGIPTPQKSWTRNDIPLV--QSDRIEMQNKNSSVLVKEISYPDTGIYTCTATNPLSE AHQSASVFIQPQDHPLSPGP-LHVFYLFHRDGIQTFEPDTCGFRLALTGASTLPD--TIK TLCSVDQVSETRRCDW-GDAVSVDDRYIYASQPYENRVVVLDARSQRIIEVISTDGQPVS LQYVEHVDSLWVLCRRSEEEAKAGRQSIMVIKSAGQPGPHHTIHTEPVG----HTFE-LV EGLFIPREQIPKQGTMNFGYIVHHNQLGLHKIDLVRMERVALIDLTAYNCHPEALNFVAI GGSVVINCAGSET-VPAKQLVLDYLTDSVIKVNEGI-RGRPYVSPDGRYIISVDANHQYV HVQKVLSESGKIKTAFEVKTNLRISDVGFFPSK-TSHTYDVFATSRDQPDVLFIDLESGF VKTITGVQTPIDDEDWPWDSRNRRIVNSGFFDPYLVTPAANHEIVINGLLRKVHCDIEDI AVANVIVWIGKC-- >NP_001027532.1 follistatin-like 5 [Apis mellifera] ----------------------------------------------------------MR -------------CML---------EIAARSFLLLSIASTY------------------- ------VVSVAGYKHSRRHRDFTVAESYDASSSNSDSLSMTIPPSID------------- ---RSSIHEESY-----------------LAESSRSIDPCASKYCGIGKECELSPNSTIA VCVCMRKCPRRH-RPVCASNGKIYANHCELHRAACHSGSSLTKSRLMRCLHHDIENA--- -----------------------------HIRRTLHMNRTSLKTSKIVSYPKSRSRKKGG LKDNLIPDKNDPDSKE-CSNQEYEIMKDNL----LLYNHARLM--SQDNH---------- --------------------SKEY-----------LVSIMFSHYDRNN-NGNLEREELEQ FAENE---------------DLEELCRG-CNLGHMISYDDTDGDGKLNVNEFYMAFSKLY SVSVVSLDKSLEVNHISARVGDNVEIKCDVTGTPPPPLVWRRNGADLETLNEPEIRVF-- NDGSLYLTKVQLIHAGNYTCHAVRNQDVVQTHVLTIHTIPEVKVTPRFQAKRLKEEANIR CHVAGEPLPRVQWLKNDEALNHDQPDKYDLIGNGTKLIIKNVDYADTGAYMCQASSIGGI TRDISSLVVQEQPTPTTESE-ERRFFSFHQWGILVYEPSACRPRHEIRSTDVIPG--TQE HVCGVKGIP----CSW-GRAINVANRYVYASQPDKDRVLVISEIQMVIVDVIPTDKNPVQ LWYVPSLDQVWILNWRNQKDIDV--KTVQVIEDAAQKKKHRAIRPEPID----AQFD-II QNIYIPEPQ-DIENIFKYGYVSHANQRNMYKLDLKNMKYTRSADLSSYNCVPINVQFSVL YGFVIIECQEPVTNRPTGQLLLDYLTDTVLAYKPKI-LGKPTISPDSRHLVTLDKQETGV TLVVQEISSDGLKFAFDVKTTLNISDIALYPSQ-TTHGYDIYASSIDKENILFLDLSTGK VEMITGVGKATSPNLTKWGNPNRPIVQSGIFGKYMVSPSNDALFVLNGETRTINCEIGGL QHPGAVVWFTVSLH >XP_039272924.1 follistatin-related protein 5-like isoform X2 [Styela clava] ----------------------------------------------------------MQ -------------NAV---------------FVVLWVVSLS------------------- ------MVIARPEKNT---------QSFDTNAPDPNEIISQLPESLDTVHSDGKIQDDIT SRRKNIVHKKRYNDANLSIELFRETLSHHVGNAESKTDRCRYMRCQPGEECLV-EDER-A KCVCKRHCKARH-HPICGTDGEYYENHCEMHRQACLSVRDIYDARHKDCFYKASECSGWE LKQYQEMMMQFYRNVMTSAKLRHNEGKDGKVQTKLNRSKRSTKKERTAERKTHR---RGG L--DIIP----GEAGDPETNKIVPPITEELDVSPSPKSRLQNDVSTSPSDTPPDQIPSAK QVVIKDSYEFLNVIQSKINLSNEYEEIMTKDSAGDMVKYIFALMDLDS-NGNVGSDEIWE ITSLQ---------------HLDNVLPGPCSLFHILKYGDTNLDRTLDISETFELF---- NISVYRLQNQKRYVHRPATYGNPMQLECGIEGESSP--VWYRYGRKVQEKNGAKVLGR-- ---TLYISDVTSKNAGNYTCSTKKKESITQTINLQIMVAPKVEIHPRTQHPSLQSSATVK CHAEGLPRPRITWKRNGESLDL-KSGRYILMANNTELHFNSVEEQDSAAYSCTAENAAGV GEDVGAIYVQTDDVHESESEASSAYFVFHEHGISIMDPHSCQLVRSIQNTERVPGLLSQD KLCDLVDDE-TRQCMW-SDSIEVGYRFIYVAQPTEDRIIVVDKQLQRVVEVITTDLMPVE LYYVKSTDQVFVVCWADSLRTG---SLIQVIHRAAVTGTHFAEHVKPVAISGHRTYDRAI HSLYIPPET-PLNPNSEYGYILHKNEAAIHRLNLATLTYSNPIDLSPYGCIPLRLNYLPI GGLLYITCESEEDGKTIHEIAIDIETDVEVIFKKNTGVAQEFFSYDYSFAIKLRPGHDMI TLHNI-SNGGEMHEFMMIRTNFQVADTYFARKKYNPESMVAYMVAKNQGDIMYVDLEKKK VEIINGMTTPAPEHAWPWRERSRKMTPSGWFGWFLATAGRTGMEILGMNSNQVLCRMDQF VRVTAVSWSGGE-F
BMGE Cleaned alignment of selected proteins >sp|Q12841|FSTL1_HUMAN Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 PE=1 SV=1 LALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >sp|Q12841-2|FSTL1_HUMAN Isoform 2 of Follistatin-related protein 1 OS=Homo sapiens OX=9606 GN=FSTL1 LALALVAVAWVRA-----------------------------------EQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >tr|Q2PMI2|Q2PMI2_DANRE Follistatin-like 1b OS=Danio rerio OX=7955 GN=fstl1b PE=1 SV=1 PVFFLLAVVCCHAEQEAQSKSKVCANVFCGAGRECAVNEKGEPSCLCIEQCKTHKRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKKEKAPVVCYVADRNELRRRVIEWLQTEVVPDGWFTKDILLKYFKNYDDSQLDSAELLKFIQHNETAVQMSSYAEEENNRLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFSPPEKKCALEDETYEDGAETQVECNRCVCACGNWVCTAMTEKTPVTEEEWTRRVAELNKHQETVEKMKT-STKEV >NP_032073.2 follistatin-related protein 1 precursor [Mus musculus] LALSLVTIALVHGEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSASPPVVCYQANRDELRRRLIQWLEAEIIPDGWFSKEILDKYFKSFDDSHLDSSEFLKFVEQNETAINITTYADQENNKLLRSLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTGKNQKTEEEKTGYVQELQKHQGTAEKTKKVNTKEI >NP_077345.1 follistatin-related protein 1 precursor [Rattus norvegicus] LALALVTIALVHGEEEQRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQANRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKSFDDSHLDSSEFLKFVEQNETAVNITAYPNQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCSCGHWVCTAMTGKNQKTEEEMTRYAQELQKHQGTAEKTKKVNTKEI >NP_989969.2 follistatin-related protein 1 precursor [Gallus gallus] LLCALLAVARLRAEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSENPPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKDVLDKYFKNFDDSRLDSTEFLKFVEQNETAVTITTYVDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCLSPSFNPPEKKCALEDETYEDGAETQVECNRCVCACGNWVCTAMTGKNEKTEEELARYVQELQKHQETAEKTKKMSTKEM >NP_001017950.1 follistatin-related protein 1 precursor [Bos taurus] LALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKAEEEMTRYVQELQKHQETAEKSKRVSTKEI >XP_038301004.1 follistatin-related protein 1 [Canis lupus familiaris] LALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNVDDSRLDSSELLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPTFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKKMSTKEI >NP_001231517.2 follistatin-related protein 1 precursor [Pan troglodytes] LALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDNYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >NP_001125838.1 follistatin-related protein 1 precursor [Pongo abelii] LALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSREILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >XP_008265088.1 PREDICTED: follistatin-related protein 1 [Oryctolagus cuniculus] LALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKPVSPPVVCYQANRDELRRRIIQWLEAEIIPDGWFSKEVLDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYADKENNKLLRGLCVDALIELSDENADWKLSFQEFLTCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKHQKEEEEMTRYIQELQKHQETAEKTKRVSTKEI >XP_003991726.1 follistatin-related protein 1 [Felis catus] LALALVAVAWVHAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNVDDSRLDSSELLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPTFNPPERKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKKVSTKEI >XP_014947951.1 follistatin-related protein 1 [Ovis aries] LALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYTDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKAEEEMTRYVQELQKHQETAEKSKRVSTKEI >XP_004082017.1 follistatin-related protein 1 [Oryzias latipes] AVLLALAAALCSAEEQQQSKSKVCANVFCGAGRECAVTEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCKEKKAEKAPVVCYAADRNELRHRLIQWLQTEIVPDGWFVKEILLKYFKIYDDSQLDSSELLKFIQHNDSVVKLQSYADQESNKLLRSLCVDALIELSDENADWKLSFDEFLNCLKPDFNPPEKKCALEDETFEDGAETQVECNRCVCACGNWVCTAMIDKHVATEEEWNLRVAELNKHQDTMEKMKT-STKEI >XP_021143523.1 follistatin-related protein 1 [Columba livia] LYYIEVAAALCILQEEPRSKSKICANVFCGAGRECTVTEKGEPTCLCIEKCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSENPPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKEVLDKYFKSFDDSRLDSTEFLEFVEQNETAVNITTYMDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCLSPSFNPPEKKCALEDENYEDGAETQVECNRCVCACGNWVCTAMTGKNEKTEEELARYVQELQKHQETAEKTKRMSTKEM >XP_017898955.1 PREDICTED: follistatin-related protein 1 isoform X1 [Capra hircus] LALALVAVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYTDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKAEEEMTRYVQELQKHQETAEKSKRVSTKEI >XP_014379598.1 follistatin-related protein 1 [Alligator sinensis] ------------MAEEPKSKSKVCANVFCGAGRECAVTEKGEPTCLCIEQCKAHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKAENPPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKEVLDKYFKSFDDSRLDSSEFLKFVEQNETAINITTYMDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCLSPSFNPPEKKCALEDETYEDGAETQVECNSCVCACGNWVCTAMTGKNGKTEEELARYVQELQKHQETAEKTKRMSTKEM >XP_019331592.1 PREDICTED: follistatin-related protein 1 [Alligator mississippiensis] CLALVLAAARLRAEEEPKSKSKVCANVFCGAGRECAVTEKGEPTCLCIEQCKAHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKAENPPVVCYQSDRDELRRRVIQWLEAEIIPDGWFSKEVLDKYFKXXXDSRLDSSEFLKFVEQNETAINITTYMDQETNKLLRGLCVDALIELSDENADWKLSFNEFLKCL----------------TYPDFLLVFIGKNGKVSPRG-------------TEEELARYVQELQKHQETAEKTKRMSTKEM >XP_020767089.1 follistatin-related protein 1 isoform X1 [Odocoileus virginianus texanus] LALALVTVAWVHAEEQVRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYADQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKAEEEMTRYVQELQKHQETAEKSKRVSTKEI >XP_015821769.1 PREDICTED: follistatin-related protein 1 [Nothobranchius furzeri] PALLLVALAVSNAEE-LKSKSKVCANVFCGAGRECAVSEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCREKKTGQAPVVCYAADRNELRSRVIQWLQTEVIPDGWFVKEILLKYFKSYADSQLDSSELLNFIQHNDSVVELHSYADQESNRLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFNPPEKKCALEDELYEDGAETQVECNRCVCACGNWVCTAMTDKHGATEEEWNLRVAELNKHQETVEKMKV-STKEV >NP_001081432.1 follistatin-related protein precursor [Xenopus laevis] PLLALL--VLCSALEEPKSKSKVCANVFCGAGRECAVTEKGDPTCLCIEKCKSHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKTSDTPPVACYQSDRDEMRRRVIHWLQTEIIPDGWFSKEILDRYFKKFDDSHLDSAELQSFLEQSQST-NITTYKDEETNRMLKSLCVEALIELSDENADWKLNKNEFLKCLNPDFQPSEKKCALEDETYEDGAETQVQCNRCVCACGNWVCTAMAGKDGDHGEDMGRYVEEIRKQQETIENSKSSSDKDA >XP_030284009.1 follistatin-related protein 1 [Sparus aurata] AALLLLAAAVCNAQE-QQSKSKVCANVFCGAGRECAVNEKGEPSCLCIESCKPHKRSVCGSNGKTYRNHCELHRDACLTGLKIQVAHDGHCQEKKSEQAPVVCYAADRNELRSRVIQWLQTEVIPDGWFVKDILHKYFKSYDDSQLDSSELLKFIQQNESVVELQSYADQESNKLLRSLCVDALIELSDENADWKLSFDEFLNCLKPGFNPPEKKCALEDETYEDGAETQVECNRCVCACGNWVCTAMTDKTAATEEEWNLRVAELNKHQETVEKMKS-STKEA >XP_020925965.1 follistatin-related protein 1 isoform X1 [Sus scrofa] LALALVAVAWVHAEEEPRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >XP_034813056.1 follistatin-related protein 1 [Pan paniscus] LALALVAVAWVRAEEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKEILDKYFKNFDDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAETEVDCNRCVCACGNWVCTAMTGKNQKTEEEMTRYVQELQKHQETAEKTKRVSTKEI >XP_040195136.1 follistatin-related protein 1 [Rana temporaria] PLLLLLAASLCRAQEEPKSKSKVCANVFCGAGRECAVTEKGDPTCLCIEKCKSHKRPVCGSNGKTYLNHCELHRDACLTGSKIQVDHDGHCKEKTSEAPPVVCYQTDRDELRRRIIQWLEAEIIPDGWFSKEILNRYFKNYDDSRLDSTEFLKFLELNQTAINITTYQDQETNKILKGLCVEALIELSDENADWKLSFNEFLKCLNPGFNPPEKKCALEDETYEDGAETQVQCNRCVCACGNWVCTAMSDKDGHPEGDMSRYVDELRKHQETIEKSKQAGSKDI >XP_031569839.1 follistatin-related protein 1-like [Actinia tenebrosa] VLLPATLYARTVKPSEEKEDNDHCANVFCHAGQEC-IIEEGNATCQCIIRCPDHKKTVCGSDGITYPSHCELHRTACVQGKKIAIENNGPCADIYPTQPPVVCYEHNRDDLRNRLIVWLR---FLDQAVDEHIFKKYFDAMDNAKLSRKEFAQLIKFNNTVGQMP-GADKFINPVLQGLCADALIAVSDEDADWELTFHEFMKCLNPAVKPPKERCELEGEYFDDGAEIPAECNTCVCACGHWVCTALNSEKAKHRNEKGDKEKVLMLYKPKQQKQRS-ERKEQ >XP_038065021.1 follistatin-related protein 1-like isoform X3 [Patiria miniata] VLTKTGKANRGRHIKKEPSQADVCAGVECGVGKECTLTTDGEASCVCVQECRRHRRLLCASDGVTYTNECELQRAACRGGIQLFIEHEGVCAHPTPTSSPIACYQDQRDTLQREIVEWLQGVRASAG---PALLEDYFARFDDNFLEPTEFLKFVEHNETLQKTTDDLNQEEDTLLRSLCVDALLAEADENFDWRLSLSEFKKVMMPGFNPPTKLCSLEGKYFMDGQEKKNKCNICICACGNWVCTANAGRFIAGERAMGENTEETVSKDTWLNIMKKLSSVDP >XP_030835975.1 follistatin-related protein 5 [Strongylocentrotus purpuratus] VGVLIAMVLTCSVEARPDPNTDACSHVECPKGSECLVNRTTNAECICRPYCKPHYKPVCGSDGVMYENHCELHRASCVSGQRITVHSHG-C--------PDTCTPEEMAQLKEELIAHYREQFHNPNEDND-IVSLILNHYDDDAISRQEMESAMTLD------------RITDLLPGCSFLDVLDSGDFDGNEKLSGMELYREFNIKAVSLSGSIAQRVTVAKVGDNLALPCEITLMHEGSYACYAEGGDAVSMNFGYIVHHNQLGLHKIDLVRMERVALIDL >NP_001027532.1 follistatin-like 5 [Apis mellifera] LLLSIASTYVVSVAGYKSRSIDPCASKYCGIGKECELSPNSTAVCVCMRKCPRRHRPVCASNGKIYANHCELHRAACHSGSSLTKSRLMRCLHHDIENAKE-CSNQEYEIMKDNLLLYNHARLM--SQDNH-LVSIMFSHYDNGNLEREELEQFAENE------------DLEELCRGCNLGHMISYDDTDGDGKLNVNEFYMAFSVSVVSLDKSLEVNHISARVGDNVEIKCDVQLIHAGNYTCHAVRGRAINFKYGYVSHANQRNMYKLDLKNMKYTRSADL >XP_039272924.1 follistatin-related protein 5-like isoform X2 [Styela clava] VVLWVVSLSMVIARPEKESKTDRCRYMRCQPGEECLV-EDERAKCVCKRHCKARHHPICGTDGEYYENHCEMHRQACLSVRDIYDARHKDCFYKASECSGDPETNKIVPPITEELSPKSRLQNDVSTSPSDDMVKYIFALMDNGNVGSDEIWEITSLQ------------HLDNVLPGCSLFHILKYGDTNLDRTLDISETFELFNISVYRLQNQKRYVHRPATYGNPMQLECGVTSKNAGNYTCSTKKSDSIESEYGYILHKNEAAIHRLNLATLTYSNPIDL
PhyML tree of selected proteins (NP_001027532_1_follistatin_like_5__Apis_mellifera_:0.79886371,(XP_031569839_1_follistatin_related_protein_1_like__Actinia_tenebrosa_:1.06182798,(XP_038065021_1_follistatin_related_protein_1_like_isoform_X3__Patiria_miniata_:1.31453123,(((((XP_020925965_1_follistatin_related_protein_1_isoform_X1__Sus_scrofa_:0.00000001,(((XP_008265088_1_PREDICTED__follistatin_related_protein_1__Oryctolagus_cuniculus_:0.02963862,((XP_014947951_1_follistatin_related_protein_1__Ovis_aries_:0.00000001,XP_017898955_1_PREDICTED__follistatin_related_protein_1_isoform_X1__Capra_hircus_:0.00000001):0.00359188,(XP_020767089_1_follistatin_related_protein_1_isoform_X1__Odocoileus_virginianus_texanus_:0.00358864,NP_001017950_1_follistatin_related_protein_1_precursor__Bos_taurus_:0.00000001):0.00000001):0.01458045):0.00000001,(XP_038301004_1_follistatin_related_protein_1__Canis_lupus_familiaris_:0.0036292,XP_003991726_1_follistatin_related_protein_1__Felis_catus_:0.00359366):0.01456459):0.00362194,(sp_Q12841_2_FSTL1_HUMAN_Isoform_2_of_Follistatin_related_protein_1_OS_Homo_sapiens_OX_9606_GN_FSTL1:0.00000001,((sp_Q12841_FSTL1_HUMAN_Follistatin_related_protein_1_OS_Homo_sapiens_OX_9606_GN_FSTL1_PE_1_SV_1:0.00000001,XP_034813056_1_follistatin_related_protein_1__Pan_paniscus_:0.00000001):0.00000001,(NP_001231517_2_follistatin_related_protein_1_precursor__Pan_troglodytes_:0.00362563,NP_001125838_1_follistatin_related_protein_1_precursor__Pongo_abelii_:0.00362402):0.00000001):0.00000001):0.00362718):0.0036341):0.00372627,(NP_077345_1_follistatin_related_protein_1_precursor__Rattus_norvegicus_:0.01818693,NP_032073_2_follistatin_related_protein_1_precursor__Mus_musculus_:0.0264306):0.0417088):0.06772882,(XP_021143523_1_follistatin_related_protein_1__Columba_livia_:0.05335509,(NP_989969_2_follistatin_related_protein_1_precursor__Gallus_gallus_:0.02280582,(XP_019331592_1_PREDICTED__follistatin_related_protein_1__Alligator_mississippiensis_:0.08042139,XP_014379598_1_follistatin_related_protein_1__Alligator_sinensis_:0.0101846):0.03451404):0.00920243):0.0342291):0.03169838,(XP_040195136_1_follistatin_related_protein_1__Rana_temporaria_:0.05312516,NP_001081432_1_follistatin_related_protein_precursor__Xenopus_laevis_:0.19562662):0.11545448):0.03691497,(tr_Q2PMI2_Q2PMI2_DANRE_Follistatin_like_1b_OS_Danio_rerio_OX_7955_GN_fstl1b_PE_1_SV_1:0.09097433,(XP_030284009_1_follistatin_related_protein_1__Sparus_aurata_:0.02744746,(XP_004082017_1_follistatin_related_protein_1__Oryzias_latipes_:0.08333311,XP_015821769_1_PREDICTED__follistatin_related_protein_1__Nothobranchius_furzeri_:0.06593432):0.01157604):0.05894158):0.19437351):0.28362366):0.15032438):2.27476299,(XP_030835975_1_follistatin_related_protein_5__Strongylocentrotus_purpuratus_:1.03111358,XP_039272924_1_follistatin_related_protein_5_like_isoform_X2__Styela_clava_:1.71403194):0.45864531);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)