PB0185

DATABASE

Click here to access PB0185 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0185	Q9BXN1	Asporin	ASPN	OS3, PLAP-1, PLAP1, SLRR1C	Homo_sapiens	Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.

Domains

Gene Ontology

PF01462 (LRRNT) PF13855 (2_LRR_8)

GO:0005509 (enables) calcium ion binding GO:0005518 (enables) collagen binding GO:0030021 (enables) extracellular matrix structural constituent conferring compression resistance GO:0030282 (involved in) bone mineralization GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway GO:0031214 (involved in) biomineral tissue development GO:0070171 (involved in) negative regulation of tooth mineralization GO:1902617 (involved in) response to fluoride GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0031012 (located in) extracellular matrix GO:0042995 (located in) cell projection GO:0062023 (part of) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q9BXN1|ASPN_HUMAN Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2 MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTR EPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKEN DFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHE NKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLP PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNK LKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQ PATFRCVLSRMSVQLGNFGM >tr|Q1LXA7|Q1LXA7_DANRE Asporin OS=Danio rerio OX=7955 GN=aspn PE=3 SV=1 MKVLLLLALLTLCNAKPYKHINVMEFMKHHDIMQQDAGDFDDDDDDDDDDDKDYDDYDDN FVTDCPEGCRCSKKVLQCSDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYA LFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMPENLPISVQSLRLHDNKISRLPKGA FKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDY NKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPPGLNT LKYLQVMYLHANSIGYVGVNDFCPSRTRAKKALYTRISLYANPVKYWEIQPPTFRCVSSH NSVQLGNHRK
Selected proteins from model organisms >sp|Q9BXN1|ASPN_HUMAN Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2 MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTR EPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKEN DFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHE NKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLP PTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNK LKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQ PATFRCVLSRMSVQLGNFGM >tr|Q1LXA7|Q1LXA7_DANRE Asporin OS=Danio rerio OX=7955 GN=aspn PE=3 SV=1 MKVLLLLALLTLCNAKPYKHINVMEFMKHHDIMQQDAGDFDDDDDDDDDDDKDYDDYDDN FVTDCPEGCRCSKKVLQCSDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYA LFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMPENLPISVQSLRLHDNKISRLPKGA FKGMHDLNVLELSANPITNSGIDVGAFDDMATLYLRIAEAKLTAIPKDLPSSLNELHLDY NKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPPGLNT LKYLQVMYLHANSIGYVGVNDFCPSRTRAKKALYTRISLYANPVKYWEIQPPTFRCVSSH NSVQLGNHRK >NP_079987.2 asporin preproprotein [Mus musculus] MKEYVMLLLLAVCSAKPFFSPSHTALKNMMLKDMEDTDDDDNDDDDNSLFPTKEPVNPFFPFDLFPTCPF GCQCYSRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFL TTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAF EGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFAN IPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSIAKVGVNDFCPTVPKMKKSLYSAISLFNNPMKYW EIQPATFRCVLGRMSVQLGNVGK >XP_414298.2 asporin [Gallus gallus] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMLQDMEEEDEDDDDDNSLFPTTEPIISLIPFDLFPTCPFGC QCYVRVVHCSDLGLTSIPRNIPPDTRMIDLQNNKIREVKENDLQGLASLYALALNNNKITKIHPKAFQPT KNLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNNDGIEPGAFEG VNIYHIRIAEAKLTSIPKDLPSSLLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIP SIREIHLEKNKLKKVPPGLPDLRYLQVVFLHSNHIAKLGVNDFCPTGRRKKKALYSGISLFNNPVKYWEV QPSTFRCILARNSVQLGNFLK >NP_001029481.1 asporin precursor [Bos taurus] MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQ CYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTK KLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGV TVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPR VREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQ PATFRCVLSRMSVQLGNFRK >XP_005616051.1 asporin [Canis lupus familiaris] MKECVFLVLLVLCSAKPSSRPSYMMLKNMMLKDTEDEMDGDPDDDNSLFPTREPINPFFPFDLFPTCPFG CQCYSRVVHCSDLGLSSVPSNIPFDTQMIDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLT TKKLRRLYLSHNQLSEIPFNLPKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDNNGIEPGAFE GVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRIADIENGSLANI PRVREIHLENNKLKKIPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVRYWE VQPATFRCVVSRMSVQLGNFRK >XP_001146178.1 asporin [Pan troglodytes] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLF PMCPFGCQCYSRVVHCSDLGLTSVPTNIPLDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIH PKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGI EPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIEN GSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNN PVKYWEMQPATFRCVLSRMSVQLGNFGM >XP_002820006.1 asporin [Pongo abelii] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDEDNSLFPTREPRSSFFPFDLFPM CPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPK AFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEP GAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGS LANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPV KYWEMQPATFRCVLSRMSVQLGNFGM >NP_001230818.1 asporin precursor [Sus scrofa] MKEYVLLLFLTLCSAKPLFRPSYMTLKNMMLKDMEEEGDDDDDNSLFPTREPINPFFPFDLFPTCPFGCQ CYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTK KLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGV TVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNRITDIENGSLANIPR VREIHLENNKLKKIPSGLQELKYLQMIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEVQ PATFRCVLGRMSVQLGNFRK >XP_003210079.1 asporin [Meleagris gallopavo] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMLQDMEEEDEDDDDDNSLFPTTEPIIPLIPFDLFPTCPFGC QCYVRVVHCSDLGLTSIPRNIPPDTRMIDLQNNKIREVKENDLQGLTTLYALALNNNKITKIHPKAFQPT KKLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNNDGIEPGAFEG VNIYHIRIAEAKLTSIPKDLPSTLLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIP SIREIHLEKNKLKKVPPGLPDLKYLQVVFLHSNHIAKLGVNDFCPTGRRKKKALYSGISLFNNPVKYWEV QPSTFRCILARNSVQLGNFLE >XP_003807889.1 asporin [Pan paniscus] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFD LFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPLDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTK IHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNN GIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDI ENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLF NNPVKYWEMQPATFRCVLSRMSVQLGNFGM >XP_003995354.1 asporin [Felis catus] MKGCVLLVLLALCSAKPLFHPSYVTLKNMMLKDMEDEGDSDLDADNSLFPTREPINPFFPFDLFPTCPFG CQCYSRVVHCSDLGLSSVPSNIPFDTQMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLT TKKLRRLYLSHNQLSEIPFNLPKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDNNGIEPGAFE GVTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRITDIENGSLANI PRVREIHLENNKLKKIPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLFNNPVRYWE VQPAAFRCVVGRMSVQLGNFRK >XP_004004126.1 asporin [Ovis aries] MKEYVLLVFLTLCSAKPLFHPSYMTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQ CYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTK KLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGV TVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPR VREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQ PATFRCVLSRMSVQLGNFRK >XP_004048312.2 asporin [Gorilla gorilla gorilla] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPF DLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLT KIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN NGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITD IENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISL FNNPVKYWEMQPATFRCVLSRMSVQLGNFGM >XP_004086170.1 asporin [Oryzias latipes] MRVLLLLCLLSFGKTKPYQPVNVMDLMKNHDIMIADSDEDDDEEDDDYDDEDCPANCRCSPQVVQCSDQG LISVPEKIPEDTMMIDLQNNDITEIKEDDFKGLHKLYGLFLINNRISKVHPNAFKNMDHLRLLYLSYNLL TEIPANLPPNVIELRFYENNINRIQKNAFDGLRKLHVLELGANPLANSGIEVGAFNGLSTLYIGIAEAKL TSVPKDLPSSIKELSLDYNKIAKVEVEDFIRYKNLQRLGLAFNQIKFVENGSLIRIPNIHEIHLDHNRLK KVPPGLNSLRYLQVIFLHNNKISYVGMNDFCPSSTGGKKNPYTGISLFANPVKYWNIQPAIFRCVTGRRA VHLGNFRKK >XP_005508936.1 asporin [Columba livia] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMVQDMEEEDDDDDDDNSLFPTTEPMIPLTPFDLFPTCPFGC QCYVRVVHCSDLGLTSIPRYIPPDTRMIDLQNNKIKEVKEKDLQGLTSLYALALNNNKITKIHPKAFQST QKLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIHKDVFKGMKSLHVLEMSANPLDNDGIEPGAFEG VNIYHIRIAEAKLTSIPKDLPSSLLELHLDDNKITAIELEDFNRYKDLQRLGLGNNKIKDVENGSFANIP SIREIHLEKNKLKKVPPGLPELKYLQVVFLHSNHIAKLGVNDFCPTGRRKKKALYSGISLFNNPVKYWEV EPSTFRCILARNSVQLGNFLK >XP_005684219.1 PREDICTED: asporin [Capra hircus] MKEYVLLVFLTLCSAKPLFHPSYMTLKNLMLKDMEDEGDSDADNSLFPTREPINPFFPFDLFSTCPFGCQ CYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTK KLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGV TVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPR VREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQ PATFRCVLSRMSVQLGNFRK >XP_006025942.1 asporin isoform X1 [Alligator sinensis] MKEYVLLLFFALCSAKPLIGPSYFTLKNMMLQDMEDADDDDDDNSLFPTREPILPLIPFDIFPVCPFGCQ CYMRVVHCSDLGLTSIPSNIPPDTRMIDLQNNKIKEVKENDLKGLTSLYALALNNNKISKIHPKAFQSTK KLRRLYLSHNQLTEIPDNLPKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDNAGIEPGAFEGV TIYHIRIAEAKLTSVPKELPSSLLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPS LREIHLERNKLKKVPPGLPYLKYLQVVFLHNNNIPKVGINDFCPTERSMKKALYSGISLFNNPMKYWEVQ PSTFRCILSANSVQLGNLRK >XP_006261182.1 PREDICTED: asporin isoform X1 [Alligator mississippiensis] MKEYVLLLFFALCSAKPLIGPSYFTLKNMMLQDMEDADDDDDDDNSLFPTREPILPLIPFDIFPVCPFGC QCYMRVVHCSDLGLTSIPSNIPPDTRMIDLQNNKIKEVKENDLKGLTSLYALALNNNKISKIHPKAFQPT KKLRRLYLSHNQLTEIPDNLPKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDNAGIEPGAFEG VTIYHIRIAEAKLTSVPKELPSSLLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIP SLREIHLERNKLKKVPPGLPYLKYLQVVFLHNNNIPKVGINDFCPTERSMKKALYSGISLFNNPMKYWEV QPSTFRCILSANSVQLGNLRK >XP_008255097.1 PREDICTED: LOW QUALITY PROTEIN: asporin [Oryctolagus cuniculus] MKESVFLLLLAALCSAKPLLSPSHLTLKNMMLKDMEDMEDDDDNDDDNSVFPTKETVHPFFPFDLFPTCP FGCQCYSRVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTF LTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGA FEGXTVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNRISDIENGSFA NIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTMPKMKKSLYSAISLSNNPVNY WEIQPATFRCVLSRMSVQLANFRK >XP_015813771.1 PREDICTED: asporin [Nothobranchius furzeri] MKVLLLFCLLTLGSSKPYQPINIMDLMKSYDIMMADSDEDEDDDDYDDEDCPAHCRCSPGVVQCSDQGLI SVPEKIPEDTVMIDLQNNDITEIQEDDFKGLNKLYGLFLNNNKISKIHPKAFRNMDHLRLLYLSYNLLTE IPANLPPNIIELRFHENNINRIQKDAFKGLRKLHVLELGANPLANSGMELGSFNGLSTLYIGIAEAKLTE VPKDLPASITELSLDYNKISKVEVEDLMRYKNLKRLGLGFNQIRSVENGSFTSIPNIHEIHLNHNRLKKV PPGLGSLRFLQAIFLHGNKISNVGFNDFCPKSVSIKKNPYSAISLFANPVKYWNIQPATFRCVISRRGVQ LGNFRKK >KAB0347446.1 hypothetical protein FD754_012303 [Muntiacus muntjak] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDEGDSDADNSLFPTREPVNPFFPFDLFSTCPFGCQCYSRVVHCSD LGLSSVPSNIPFDTRLIDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLP KSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPSTLLELHLDY NKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVN DFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK >XP_043309693.1 asporin [Cervus canadensis] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDEGDSDADNSLFPTREPVNPFFPFDLFSTCPFGCQCYSRVVHCSD LGLSSVPSNIPFDTRLVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLP KSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKDLPSTLLELHLDY NKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVN DFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK >KAB0373557.1 hypothetical protein FD755_015216 [Muntiacus reevesi] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDEGDSDADNSLFPTREPVNPFFPFDLFSTCPFGCQCYSRVVHCSD LGLSSVPSNIPFDTRLIDLQNNKIKEIKENDFKGLTSLYALILNNNKLSKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLP KSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKDLPSTLLELHLDY NKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVN DFCPTVPKMKKSLYSAISLSNNPVKYWEVQPATFRCVLSRMSVQLGNFRK >NP_001014030.1 asporin precursor [Rattus norvegicus] MKEYMMLLLLAVCSAKPFFSPSHTALKTMMLKDMEDTDDEDNDDDDDDNSLFPTKEPVNPFFPFDLFPTCPFGCQCYSRV VHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEI PLNLPRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLE LHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHNNSIT KVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQPATFRCVVGRMSVQLGNVGK >NP_001088205.1 asporin L homeolog [Xenopus laevis] MKEYLLFYFLALCYAKPFILPPKYMALTDLMLKDMEDDDDDDDDNDDDDNSLFPFKKNLPVRPTPPPFDLFPSCPFGRQC YLKIVQCSDLGLTSIPNKIPYDTRLLDLQNNKIKEIKEKDLQGLTSLSALFLNNNKLYKVHPKAFQSTKKLRRLYLSHNQ LTEIPSNLPKSLAEIRIHDNKVKKVQKEAFKGIHSLHVLEMSANPLESEGIEPGAFDGLTVFHIRIADAKLTSIPKDLPT SIYQLHLDHNKISGIELEDLLRYKELQRLGLGHNKIKDVENGSFASIPNVREIHLENNKLRRVPPGLADLKYLQVLFLHS NNIGKVDVNDFCPTGLKLKKSLYSGISLFKNPVKYWEVQPATFRCTLGRNSVHLGNFRK >XP_040178826.1 biglycan [Rana temporaria] MKVLLLICTSVLLCNALPFEQRGFWDFSMDDGLTMMRDEANEEGSGFSTATPGKKGPTAFPPHMPPMDLCPFGCQCHLRV VQCSDLGLTSVPKNIPKDTMLLDLQNNKIMEIKKDDLKGLSKLYALVLVNNKISKVNEKAFEPCSNLQKLYISKNSLEEI PKSLPKSLVELRIHENKIKKIPKDVFNGLKNMNCIELGGNPLENGGIDAGAFNGLKLNYLRISEAKLSGIPKGLPASLNE LHLDHNRIQAVEMGDLSTLPNLYRLGLGYNIIRQVENGSLSSLPILRELHLDNNKLAKVPPGLPDLKFLQVVYLHSNNIT QVGVNDFCPTGFGVKRAYYNGISLFNNPVPYWEVQPATFRCVTDRLAIQFGNYRK >XP_020738805.1 asporin [Odocoileus virginianus texanus] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDEGDSDADNSLFPTREPVNPFFPFDLFSTCPFGCQ CYSRVVHCSDLGLSSVPSNIPFDTRLVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTK KLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGV TVFHIRIAEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPR VREIHLENNKLKKVPSGLQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSLYSAISLSNNPVKYWEVQ PATFRCVLSRMSVQLGNFRK >XP_030276561.1 asporin [Sparus aurata] MRVFLLLCLLALGNAKPYQPINVMDFMKNFDIMMADAGDDDDDDDDDDDDDDDYDDENCPAGCRCSPGVV QCSDQGQISVPEKIPEDTLLLDLQNNDITEIKEDDFKGLNRLYGLFLINNKISKIHPRAFRNMERLKLLY LSYNLLTEIPANLPPNVIELRFHENKINKIQKDAFKGLRKLHVLELGANPLANSGIELGAFNGLSSLYVG MAEAKLTAVPKDLPNAITELNLDYNKIGKVEVEDFIRYKNLLRLRLGFNQIKSVENGSFVSIPNVREIHL DNNRLRKVPPGLNSLRYLQVIFLHGNKISNVGVNDFCPIRASVKKNLYTGISLFANPVKYWEVQPATFRC VTGRRGVQLGNFRK >XP_039255120.1 slit homolog 1 protein-like [Styela clava] MTISRMKREKKLTCVLNSKSSLGPSFLIRQTVTKMNPIKMDYSGAKMTTRGGKSHSSLTSLILCFVILSKADLSTACPSM CTCASTSVDCTHQSLSSIPAGIPTDTVTLDMRNNQIATLSADAFAGLTSLEKLYLDTIQLVTIESGAFNGLTALKELTMT ANSITALPDSIFSSLGSTLIKIDLKSNQLNTLSASTFSGLTNLETLDLSSNQLTTLPANVFSDLSTLTSLDLSSNKLASI PTDSLNGLTSLPLLKLDSNLITSMDAGVLAPLTSLTKVSLVGNSLTTVPTGVFVDHSTLQEIDLQDNQITVLSSTMFSNL ADIRVIKLRSNQISSVGVAATHAFFNIKATLRQIDLSNNQLTQIFLYQFLSLTNLEIIDLSQNQITSVDQGFFTLQSLST IKLQYNQISSITAQAFGLQSLVTVDLSYNQLTTIPSDAFQSDLTASLVETVYLNDNQLTTVEADAFTHCPNIRTIVLKRN LISSIVASSFSGLEQLRTVDLSSNQLTSIPGDSFKDLPRLTSIDFTINRLESVLSGAFTNLAAVVELDLSSNVIHTIESG AFTSVPVLATLTLNINKLTAVPKTGIESLTSLVTLDLSSNLIEGLSEANAFGDLTSLETLYLHNNSLSSLASDCLAGLSA IKNITMYDNSISALSASLSSSTSLSSLISLNFQSNSISSISADAFTGFSALQTLILRGNSLTTIPATTLDVCQATLSDLQ LDENSWTCDCDLQWVIDDFSNAINGGSCSSPAELAGKALSGAGAITSSEICAPTTTTMTTTTTTTVIAPVVIHTPSQEIN VKIGETATLPCVSSGIPAPTVVWTTPSGGVIFSTGKYNVDSSTGTLTITGITDNLAGYYVCTASNSLGDQASINIRVWVW FPPYITNFVEAAIVSDSDECHALPCDVNAYPAATFTWIVPNTSTITGIDTGSIIMTSTGKLYFSTPAESSTGYYNCTASN SEGSVSREAFAYIYNATEVNVDPVTVLAAEGSSVELDGSVVFSTSGFVWSLPSGNLVMASILLRGSSSSTGSTDSGTSDN GNTVTDGNTGTDGDNGTDGNTGTDGNTGTDGNTGTDGSTDSGNGGTLSVAYRITNNELVYSSESLSQAYSVNTTTGSLIV QSVTSSSSGSAIGVTTGTYRLLTPRGTLTFNLAIDTNSTDGVAVSSNSTTNTTVGAEAISGSGISTTAIYYICLSAILFC IVCTFLACVYIFRKGKKNKYKEAVATPKAIKTY >XP_030827829.1 leucine-rich repeats and immunoglobulin-like domains protein 3 [Strongylocentrotus purpuratus] MATYSSQIFRCFYTVLVVYCLLLDTAKYVSGQNVLCPEECWCLGSLVDCSKRHLTSIPTDLPTWVTMLELQSNRIASIPD GTFDRLSQLEDLDLSSNKLRRLNASTFDGLSNLQQLKLASNKLTSLPILGPSARNLTQLILHHNRITNISPAALRGLTSL RTLDLSYNRIGHLRTDTFPTDNRLQFLLLENNRISTLQQGCLNNLRSLEILKLNRNRIASLPRDLFTHLESLNLLELSRN ELTTVDSLVFSGLESLEELSLSRNQLTDLMDGAFYGLNAIQQLELDGNELTTISRRWLFGLKSLLHLTVAHNRINETEAS GWEFCPNLEYLDLSHNRLTTLETEEESVGESGGPAAQGTSGGAPGSVGVPPWPPLLRELYINHNRVTQVADGAFIQLNLL QVLDLSDNVIAWTVDDMTGAFEGLESLLRLGLANNNINSISRRAFSGLVNLQSLDFAGNVITTVENNAFEGMPQLTQLLV NSSSMVCDCQMAWFPVWIKENNLGEGVDGRCAHPDTLQGLDIFSVDPEVFTCDDRLKPFIIREPETVTSLKNDNVSLICT AGSTSDVQVTMLWKKDKAIMEDANPIYFERLNPSGVNEYTSVLNLPHIKEADQGRFQCIISNEFGVTYSKKARVTVHIYP SFTVTPRHVSVRVGGIAELPCAATGHPTPKIAWQKDGGINFPAARQRRIKVKTELAEFYIDNVQISDTGVYTCTALNAAG TISTNATLTVLEPPLFTRQMKDLTVEVGEPAVLECNVEGSPRPSIRWFKDEEPFTLSDGMHLTDFDRYLIIMNAAGRDGG TYTCEATNSLGVRTDTAKLVVTQNSGTVWNMTTTSIIIVVVICCILGTSLIWVVIIYHTRKRTSRYRVEESHHHVVPPEI PSSTLNGSSEGTIHQETSSGVSSAATDKYQDDNASDCDSLDGPVGKLSTFRFSNQVRMAAIFPSETKVIQPPELAPCPRQ HHCNIQDGPHQSGMERYCPSDSLSEADRTTLERRGQLTALPCCNGTGRSLDSAINKHMYLHHGGGGGRNHPLRKGGSDGE EGEIEEEDEDEVFMDEATRDRLQRERLLTNSDEGLGSQTASPVNRHNYRRSNHPPPQCCHSYTSVSSPEGRCTSPSSFNI PHENAQRGDAYSRMAMSSSSLPCNGRIPNVHLYENPTSSTQDKDLIDGHLCRSHNHVNNVNNNSNTNHSPVADPIRQSHS IPTAISSTGNVSPGIGALLSPTTPPTTTHQVQNGHLHSHHRPHHPNRHNEKPTHQNSRKSGRHPEKHHVKSKTSPKSGQS IPRTSYLPSSNAHPAHHVTSPTLTSLTEA >CAA37910.1 slit protein [Drosophila melanogaster] MAAPSRTTLMPPPFRLQLRLLILPILLLLRHDAVHAEPYSGGFGSSAVSSGGLGSVGIHIPGGGVGVITEARCPRVCSCT GLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLDISNNVI TTVGRRVFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTSLPHNIFGGLGRLRALRLSDNPFACDCHLSW LSRFLRSATRLAPYTRCQSPSQLKGQNVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTL PDDTTDVRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSGVFKGLGSLRLLL LNANEISCIRKDAFRDLHSLSLLSLYDNNIQSLANGTFDAMKSMKTVHLAKNPFICDCNLRWLADYLHKNPIETSGARCE SPKRMHRRRIESLREEKFKCSWGELRMKLSGECRMDSDCPAMCHCEGTTVDCTGRRLKEIPRDIPLHTTELLLNDNELGR ISSDGLFGRLPHLVKLELKRNQLTGIEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFE HLNSLTSLNLASNPFNCNCHLAWFAECVRKKSLNGGAARCGAPSKVRDVQIKDLPHSEFKCSSENSEGCLGDGYCPPSCT CTGTVVACSRNQLKEIPRGIPAETSELYLESNEIEQIHYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLIISYN KLQCLQRHALSGLNNLRVVSLHGNRISMLPEGSFEDLKSLTHIALGSNPLYCDCGLKWFSDWIKLDYVEPGIARCAEPEQ MKDKLILSTPSSSFVCRGRVRNDILAKCNACFEQPCQNQAQCVALPQREYQCLCQPGYHGKHCEFMIDACYGNPCRNNAT CTVLEEGRFSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQPGFSGEFCDTKIQFCSPEFNPCANGAK CMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHMCQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHEC KHGVCFQPNAQGSDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPLRTRPEANVTIVFSSAEQNGILMYDGQDAHLAV ELFNGRIRVSYDVGNHPVSTMYSFEMVADGKYHAVELLAIKKNFTLRVDRGLARSIINEGSNDYLKLTTPMFLGGLPVDP AQQAYKNWQIRNLTSFKGCMKEVWINHKLVDFGNAQRQQKITPGCALLEGEQQEEEDDEQDFMDETPHIKEEPVDPCLEN KCRRGSRCVPNSNARDGYQCKCKHGQRGRYCDQGEGSTEPPTVTAASTCRKEQVREYYTENDCRSRQPLKYAKCVGGCGN QCCAAKIVRRRKVRMVCSNNRKYIKNLDIVRKCGCTKKCY >XP_038059677.1 relaxin receptor 2-like isoform X1 [Patiria miniata] MHKLRNALRMLLILHVCAARRVKQDSALRHLQRRTVDAHKHCGVDFPCLNSTQCVPQDAICDGTPDCDNGSDEWEMEECR DLNLAKMWDDFFGTKDESGEEEEDDVNQGLSPDPLPQRSFDAHGHCGEDFPCINSTQCVPQEAICNGEPDCDNGSDEWEL EECRDWNLAKMWDDFFGDKAEDEDVRREIPCEKGTFPESCDCFVEIEETRKDLPSLASPFNATGDASMGAGVDDVGTETN VTDGIPYGLGVQGVVVGVRLDCSARQLTEFPRNLPNKTISLDLSDNKITSLTKKDMEHLTHLRQLLLSRNKLQNVEEGTF ESLTDLQTLRMIACDLEDVPPRMFATQNRLVTLDLSYNILTRLVRGSLFGLHNLEYLDIRGNRLAEIETGVFKDSSRIYF MHISQNRLSSIPAELFRPLRDLRSLNIHRNDISSIECGSFSTNTKLRDLNLGDNKLTEIKRGLFHNLTSVITLSLRNNSI RHFEEDAFAGMNNLQTLKLNQNPFTSVPIGIFDKLRSLKAIYFDHFSLCGYAPHVRLCMPKSDGISTAENLLANNLLRFA VWFVALLASLGNAFVLLARCFVKEDKKTHSFFIMNLAVADLLMGLYLLIIGIHDVIFRGVYILHDLAWRTSSVCKLSGFL SLLSSEVSIMTLTVITMDRFLSIVHPFRFKNRSLVHARLLMVLLWLLGVALATIPLLHTEYFGEFYYGGNGVCLPLQIDQ PFANGWQFSLVIFVVFNLVAFAFISYAYLMMFVTIRRSNLAMRSTKKNQDWALVKRFTLIVATDFVCWMPIIIVKFVALG GVSVSNSVYAWFAIFVLPINSALNPILYTMTTVLFKQKVLAPLGIVRAKRKKGYLTGISVDDTSTMSKNSGTRLSIISTK SRGGSVNGRFSSHKKLKNFDSLDSSDESVICTATKTTTKKRAVTVEYHQLPVSDSDERPLASTVT
Mafft alignment of selected proteins >sp|Q9BXN1|ASPN_HUMAN Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2 ------------MKEYVLLLFL-ALCSAKPF-FSPSHIAL-------------------- ----------------------------KNMMLKDMEDT-DDDDDDDDDDDDDDEDNSLF PTRE-------PRSHF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPMCPFGCQCYSRVV----HCSDLGLTSVPTNIPFDTRMLDLQNNK IKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKGL---PPT LLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK KIPS----GL-PELKYLQIIFLHSNSIARVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEM------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FGM-- ------------------------------------------------ >tr|Q1LXA7|Q1LXA7_DANRE Asporin OS=Danio rerio OX=7955 GN=aspn PE=3 SV=1 ------------MKVLLLLALL-TLCNAKPY-KHINVMEFM------------------- --------------------------KHHDIMQQDAGDF------DDDDDDDDDDDKDYD D----------------------------------------------------------- ----------------------------YD------------------------------ -----------DNFVTDCPEGCRCSKKVL----QCSDQGLTKVPKDIPANTLLLDLQNND ITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMP----ENL PISVQSLRLHDNKISRLPKGAFKGMHDLNVLELSANPITN-------------------- --SGIDVGAFDDMATLY-LRIA-------------------------------------- -------------------------------------------EAKLTAIPKDL---PSS LNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLK KIPP----GL-NTLKYLQVMYLHANSIGYVGV---NDFCPSRTRAKK------------- ----ALY--TRISLYANPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEI------ ------------------------------------------------------------ ---------------------------------QPPT--------------------FRC VSS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -HNSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------HRK-- ------------------------------------------------ >NP_079987.2 asporin preproprotein [Mus musculus] ------------MKEYVMLLLL-AVCSAKPF-FSPSHTAL-------------------- ----------------------------KNMMLKDMEDT--------DDDDNDDDDNSLF PTKE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLTSVPNNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLEN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKGL---PPT LLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLK KIPS----GL-QELKYLQIIFLHYNSIAKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPMK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEI------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VGK-- ------------------------------------------------ >XP_414298.2 asporin [Gallus gallus] ------------MKEYTLLLFL-ALCSAKPL-IGPSYFTL-------------------- ----------------------------KNMMLQDMEEE----------DEDDDDDNSLF PTTE-------PIISL-------------------------------------------- ----------------------------IP------------------------------ -----------FDLFPTCPFGCQCYVRVV----HCSDLGLTSIPRNIPPDTRMIDLQNNK IREVKENDLQGLASLYALALNNNKITKIHPKAFQPTKNLRRLYLSHNQLTEIP----TNL PKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNN-------------------- --DGIEPGAFEGVNIYH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKDL---PSS LLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLK KVPP----GL-PDLRYLQVVFLHSNHIAKLGV---NDFCPTGRRKKK------------- ----ALY--SGISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPST--------------------FRC ILA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RNSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FLK-- ------------------------------------------------ >NP_001029481.1 asporin precursor [Bos taurus] ------------MKVYVLLVFL-TLCSAKPL-FHPSYLTL-------------------- ----------------------------KNLMLKDMEDE-----------GDSDADNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_005616051.1 asporin [Canis lupus familiaris] ------------MKECVFLVLL-VLCSAKPS-SRPSYMML-------------------- ----------------------------KNMMLKDTEDE---------MDGDPDDDNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTQMIDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----FNL PKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRIADIENGSLANIPRVREIHLENNKLK KIPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VVS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_001146178.1 asporin [Pan troglodytes] ------------MKEYVLLLFL-ALCSAKPF-FSPSHIAL-------------------- ----------------------------KNMMLKDMEDT---DDDDDDDDDDDDEDNSLF PTRE-------PRSHF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPMCPFGCQCYSRVV----HCSDLGLTSVPTNIPLDTRMLDLQNNK IKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKGL---PPT LLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK KIPS----GL-PELKYLQIIFLHSNSIARVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEM------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FGM-- ------------------------------------------------ >XP_002820006.1 asporin [Pongo abelii] ------------MKEYVLLLFL-ALCSAKPF-FSPSHIAL-------------------- ----------------------------KNMMLKDMEDT-----DDDDDDDDDDEDNSLF PTRE-------PRSSF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPMCPFGCQCYSRVV----HCSDLGLTSVPTNIPFDTRMLDLQNNK IKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKGL---PPT LLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK KIPS----GL-PELKYLQIIFLHSNSIARVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEM------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FGM-- ------------------------------------------------ >NP_001230818.1 asporin precursor [Sus scrofa] ------------MKEYVLLLFL-TLCSAKPL-FRPSYMTL-------------------- ----------------------------KNMMLKDMEEE-----------GDDDDDNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISTVELEDFKRYKELQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KIPS----GL-QELKYLQMIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_003210079.1 asporin [Meleagris gallopavo] ------------MKEYTLLLFL-ALCSAKPL-IGPSYFTL-------------------- ----------------------------KNMMLQDMEEE----------DEDDDDDNSLF PTTE-------PIIPL-------------------------------------------- ----------------------------IP------------------------------ -----------FDLFPTCPFGCQCYVRVV----HCSDLGLTSIPRNIPPDTRMIDLQNNK IREVKENDLQGLTTLYALALNNNKITKIHPKAFQPTKKLRRLYLSHNQLTEIP----TNL PKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNN-------------------- --DGIEPGAFEGVNIYH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKDL---PST LLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLK KVPP----GL-PDLKYLQVVFLHSNHIAKLGV---NDFCPTGRRKKK------------- ----ALY--SGISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPST--------------------FRC ILA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RNSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FLE-- ------------------------------------------------ >XP_003807889.1 asporin [Pan paniscus] ------------MKEYVLLLFL-ALCSAKPF-FSPSHIAL-------------------- ----------------------------KNMMLKDMEDT-DDDDDDDDDDDDDDEDNSLF PTRE-------PRSHF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPMCPFGCQCYSRVV----HCSDLGLTSVPTNIPLDTRMLDLQNNK IKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKGL---PPT LLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK KIPS----GL-PELKYLQIIFLHSNSIARVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEM------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FGM-- ------------------------------------------------ >XP_003995354.1 asporin [Felis catus] ------------MKGCVLLVLL-ALCSAKPL-FHPSYVTL-------------------- ----------------------------KNMMLKDMEDE---------GDSDLDADNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTQMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----FNL PKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KIPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAA--------------------FRC VVG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_004004126.1 asporin [Ovis aries] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNLMLKDMEDE-----------GDSDADNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_004048312.2 asporin [Gorilla gorilla gorilla] ------------MKEYVLLLFL-ALCSAKPF-FSPSHIAL-------------------- ----------------------------KNMMLKDMEDTDDDDDDDDDDDDDDDEDNSLF PTRE-------PRSHF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPMCPFGCQCYSRVV----HCSDLGLTSVPTNIPFDTRMLDLQNNK IKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKGL---PPT LLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLK KIPS----GL-PELKYLQIIFLHSNSIARVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEM------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FGM-- ------------------------------------------------ >XP_004086170.1 asporin [Oryzias latipes] ------------MRVLLLLCLL-SFGKTKPY-QPVNVMDLM------------------- --------------------------KNHDIMIADS------------DEDDDEEDDDYD D----------------------------------------------------------- ------------------------------------------------------------ ---------------EDCPANCRCSPQVV----QCSDQGLISVPEKIPEDTMMIDLQNND ITEIKEDDFKGLHKLYGLFLINNRISKVHPNAFKNMDHLRLLYLSYNLLTEIP----ANL PPNVIELRFYENNINRIQKNAFDGLRKLHVLELGANPLAN-------------------- --SGIEVGAFNGLSTLY-IGIA-------------------------------------- -------------------------------------------EAKLTSVPKDL---PSS IKELSLDYNKIAKVEVEDFIRYKNLQRLGLAFNQIKFVENGSLIRIPNIHEIHLDHNRLK KVPP----GL-NSLRYLQVIFLHNNKISYVGM---NDFCPSSTGGKK------------- ----NPY--TGISLFANPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWNI------ ------------------------------------------------------------ ---------------------------------QPAI--------------------FRC VTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RRAVHL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRKK- ------------------------------------------------ >XP_005508936.1 asporin [Columba livia] ------------MKEYTLLLFL-ALCSAKPL-IGPSYFTL-------------------- ----------------------------KNMMVQDMEEE----------DDDDDDDNSLF PTTE-------PMIPL-------------------------------------------- ----------------------------TP------------------------------ -----------FDLFPTCPFGCQCYVRVV----HCSDLGLTSIPRYIPPDTRMIDLQNNK IKEVKEKDLQGLTSLYALALNNNKITKIHPKAFQSTQKLRRLYLSHNQLTEIP----TNL PKTLAELRIHANKVKKIHKDVFKGMKSLHVLEMSANPLDN-------------------- --DGIEPGAFEGVNIYH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKDL---PSS LLELHLDDNKITAIELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLK KVPP----GL-PELKYLQVVFLHSNHIAKLGV---NDFCPTGRRKKK------------- ----ALY--SGISLFNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------EPST--------------------FRC ILA--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RNSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FLK-- ------------------------------------------------ >XP_005684219.1 PREDICTED: asporin [Capra hircus] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNLMLKDMEDE-----------GDSDADNSLF PTRE-------PINPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_006025942.1 asporin isoform X1 [Alligator sinensis] ------------MKEYVLLLFF-ALCSAKPL-IGPSYFTL-------------------- ----------------------------KNMMLQDMEDA-----------DDDDDDNSLF PTRE-------PILPL-------------------------------------------- ----------------------------IP------------------------------ -----------FDIFPVCPFGCQCYMRVV----HCSDLGLTSIPSNIPPDTRMIDLQNNK IKEVKENDLKGLTSLYALALNNNKISKIHPKAFQSTKKLRRLYLSHNQLTEIP----DNL PKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDN-------------------- --AGIEPGAFEGVTIYH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKEL---PSS LLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPSLREIHLERNKLK KVPP----GL-PYLKYLQVVFLHNNNIPKVGI---NDFCPTERSMKK------------- ----ALY--SGISLFNNPMK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPST--------------------FRC ILS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ANSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LRK-- ------------------------------------------------ >XP_006261182.1 PREDICTED: asporin isoform X1 [Alligator mississippiensis] ------------MKEYVLLLFF-ALCSAKPL-IGPSYFTL-------------------- ----------------------------KNMMLQDMEDA----------DDDDDDDNSLF PTRE-------PILPL-------------------------------------------- ----------------------------IP------------------------------ -----------FDIFPVCPFGCQCYMRVV----HCSDLGLTSIPSNIPPDTRMIDLQNNK IKEVKENDLKGLTSLYALALNNNKISKIHPKAFQPTKKLRRLYLSHNQLTEIP----DNL PKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDN-------------------- --AGIEPGAFEGVTIYH-IRIA-------------------------------------- -------------------------------------------EAKLTSVPKEL---PSS LLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPSLREIHLERNKLK KVPP----GL-PYLKYLQVVFLHNNNIPKVGI---NDFCPTERSMKK------------- ----ALY--SGISLFNNPMK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPST--------------------FRC ILS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -ANSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------LRK-- ------------------------------------------------ >XP_008255097.1 PREDICTED: LOW QUALITY PROTEIN: asporin [Oryctolagus cuniculus] ------------MKESVFLLLLAALCSAKPL-LSPSHLTL-------------------- ----------------------------KNMMLKDMEDM--------EDDDDNDDDNSVF PTKE-------TVHPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLTSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLEN-------------------- --NGIEPGAFEGXTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISTVELEDFKRYKELQRLGLGNNRISDIENGSFANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTMPKMKK------------- ----SLY--SAISLSNNPVN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEI------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------A N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_015813771.1 PREDICTED: asporin [Nothobranchius furzeri] ------------MKVLLLFCLL-TLGSSKPY-QPINIMDLM------------------- --------------------------KSYDIMMADS--------------DEDEDDDDYD D----------------------------------------------------------- ------------------------------------------------------------ ---------------EDCPAHCRCSPGVV----QCSDQGLISVPEKIPEDTVMIDLQNND ITEIQEDDFKGLNKLYGLFLNNNKISKIHPKAFRNMDHLRLLYLSYNLLTEIP----ANL PPNIIELRFHENNINRIQKDAFKGLRKLHVLELGANPLAN-------------------- --SGMELGSFNGLSTLY-IGIA-------------------------------------- -------------------------------------------EAKLTEVPKDL---PAS ITELSLDYNKISKVEVEDLMRYKNLKRLGLGFNQIRSVENGSFTSIPNIHEIHLNHNRLK KVPP----GL-GSLRFLQAIFLHGNKISNVGF---NDFCPKSVSIKK------------- ----NPY--SAISLFANPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWNI------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VIS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RRGVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRKK- ------------------------------------------------ >KAB0347446.1 hypothetical protein FD754_012303 [Muntiacus muntjak] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNMMLKDMEDE-----------GDSDADNSLF PTRE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRLIDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKGL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_043309693.1 asporin [Cervus canadensis] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNMMLKDMEDE-----------GDSDADNSLF PTRE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRLVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKDL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >KAB0373557.1 hypothetical protein FD755_015216 [Muntiacus reevesi] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNMMLKDMEDE-----------GDSDADNSLF PTRE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRLIDLQNNK IKEIKENDFKGLTSLYALILNNNKLSKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKDL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >NP_001014030.1 asporin precursor [Rattus norvegicus] ------------MKEYMMLLLL-AVCSAKPF-FSPSHTAL-------------------- ----------------------------KTMMLKDMEDT------DDEDNDDDDDDNSLF PTKE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFPTCPFGCQCYSRVV----HCSDLGLTSVPSNIPFDTRMVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIP----LNL PRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKGL---PPT LLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLK KIPS----GL-QELKYLQIIFLHNNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLFNNPMK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEI------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VVG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------VGK-- ------------------------------------------------ >NP_001088205.1 asporin L homeolog [Xenopus laevis] ------------MKEYLLFYFL-ALCYAKPFILPPKYMAL-------------------- ----------------------------TDLMLKDMEDD------DDDDDDNDDDDNSLF PFKKN-----LPVRPT-------------------------------------------- ---------------------------PPP------------------------------ -----------FDLFPSCPFGRQCYLKIV----QCSDLGLTSIPNKIPYDTRLLDLQNNK IKEIKEKDLQGLTSLSALFLNNNKLYKVHPKAFQSTKKLRRLYLSHNQLTEIP----SNL PKSLAEIRIHDNKVKKVQKEAFKGIHSLHVLEMSANPLES-------------------- --EGIEPGAFDGLTVFH-IRIA-------------------------------------- -------------------------------------------DAKLTSIPKDL---PTS IYQLHLDHNKISGIELEDLLRYKELQRLGLGHNKIKDVENGSFASIPNVREIHLENNKLR RVPP----GL-ADLKYLQVLFLHSNNIGKVDV---NDFCPTGLKLKK------------- ----SLY--SGISLFKNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC TLG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RNSVHL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_040178826.1 biglycan [Rana temporaria] ------------MKVLLLICTSVLLCNALPF-EQRGFWDFS------------------- ----------------------------MDDGLTMMRDE---------ANEEGSGFSTAT PGKKG------PTA---------------------------------------------- ----------------------------FPPH---------------------------- -----------MPPMDLCPFGCQCHLRVV----QCSDLGLTSVPKNIPKDTMLLDLQNNK IMEIKKDDLKGLSKLYALVLVNNKISKVNEKAFEPCSNLQKLYISKNSLEEIP----KSL PKSLVELRIHENKIKKIPKDVFNGLKNMNCIELGGNPLEN-------------------- --GGIDAGAFNGLKLNY-LRIS-------------------------------------- -------------------------------------------EAKLSGIPKGL---PAS LNELHLDHNRIQAVEMGDLSTLPNLYRLGLGYNIIRQVENGSLSSLPILRELHLDNNKLA KVPP----GL-PDLKFLQVVYLHSNNITQVGV---NDFCPTGFGVKR------------- ----AYY--NGISLFNNPVP---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VTD--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RLAIQF----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------YRK-- ------------------------------------------------ >XP_020738805.1 asporin [Odocoileus virginianus texanus] ------------MKEYVLLVFL-TLCSAKPL-FHPSYMTL-------------------- ----------------------------KNMMLKDMEDE-----------GDSDADNSLF PTRE-------PVNPF-------------------------------------------- ----------------------------FP------------------------------ -----------FDLFSTCPFGCQCYSRVV----HCSDLGLSSVPSNIPFDTRLVDLQNNK IKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIP----LNL PKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDN-------------------- --NGIEPGAFEGVTVFH-IRIA-------------------------------------- -------------------------------------------EAKLTSIPKEL---PST LLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLK KVPS----GL-QELKYLQIIFLHSNSITKVGV---NDFCPTVPKMKK------------- ----SLY--SAISLSNNPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VLS--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RMSVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_030276561.1 asporin [Sparus aurata] ------------MRVFLLLCLL-ALGNAKPY-QPINVMDFM------------------- --------------------------KNFDIMMADAGDD------DDDDDDDDDDDDDYD D----------------------------------------------------------- ------------------------------------------------------------ ---------------ENCPAGCRCSPGVV----QCSDQGQISVPEKIPEDTLLLDLQNND ITEIKEDDFKGLNRLYGLFLINNKISKIHPRAFRNMERLKLLYLSYNLLTEIP----ANL PPNVIELRFHENKINKIQKDAFKGLRKLHVLELGANPLAN-------------------- --SGIELGAFNGLSSLY-VGMA-------------------------------------- -------------------------------------------EAKLTAVPKDL---PNA ITELNLDYNKIGKVEVEDFIRYKNLLRLRLGFNQIKSVENGSFVSIPNVREIHLDNNRLR KVPP----GL-NSLRYLQVIFLHGNKISNVGV---NDFCPIRASVKK------------- ----NLY--TGISLFANPVK---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------YWEV------ ------------------------------------------------------------ ---------------------------------QPAT--------------------FRC VTG--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -RRGVQL----------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------------G N----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------FRK-- ------------------------------------------------ >XP_039255120.1 slit homolog 1 protein-like [Styela clava] MT------ISRMKREKKLTCVL----NSKSS-LGPSFLIRQ------------------- --------------------------TVTKMNPIKMDYS-----GAKMTTRGGKSHSSLT SLIL-------------------------------------------------------- ----------------------------------CFV----------------------- -------ILSKADLSTACPSMCTCASTSV----DCTHQSLSSIPAGIPTDTVTLDMRNNQ IATLSADAFAGLTSLEKLYLDTIQLVTIESGAFNGLTALKELTMTANSITALPDSIFSSL GSTLIKIDLKSNQLNTLSASTFSGLTNLETLDLSSNQLTT-------------------- ----LPANVFSDLSTLTSLDLS-------------------------------------- -------------------------------------------SNKLASIPTDSLNGLTS LPLLKLDSNLITSMDAGVLAPLTSLTKVSLVGNSLTTVPTGVFVDHSTLQEIDLQDNQIT VLSS----TMFSNLADIRVIKLRSNQISSVGVAATHAFFNIKATLRQIDLSNNQLTQIFL YQFLSLTNLEIIDLSQNQITSVDQGFF-TLQSLSTIKLQYN------------------- -----------------QISSITAQAFGLQ------------------------SLVTVD LSYNQLTTIPSDAFQSDLTASLVETVYLNDNQLTTVEADA-FTHCPNIRTIVLKRNLISS IVASSFSGLEQLRTVDLSSNQLTSIPGDSFKDLPRLTSIDFTINRLESVLSGAFTNLAAV VELDLSSNVIHTIESGAFTSVPVLATLTLNINKLT---AVPKTGIESLTSLVTLDLSSNL IEGLSEANAFGDL-------------------------------TSLETLYLHNNSLSSL ASDCLAGLSAIKNITMYDNSISALSA-SLSSSTSLSSLISLNFQSNSISSISADAFTGFS ALQTLILRGNSLTTIPATTLDVC-------QATLSDLQLDENSWTCDCDLQWVIDDFS-N AINGG---SCSSPAELAGKALSGAGAITSSEICAPTTTTMTTTTTTTVI----------- ---------------------------------APVVIHTPSQEINVKI---GETATLPC VSS-------------------------------------------GIPAPTVVWTTPSG GVIFSTGK---YNVDSS---TGTLTITGITDNLAGYYVCTASNSLGDQASINIRVWVWFP PYITNFVEAAIVSDSDECHALPCDVNAYPAATFTWI-------VPNTSTITGIDTGSIIM TSTGKL-------YFSTPAESSTGYYN-------------------------CTASNSEG S---------------VSREAFAYIYNATEVNVDPVTVLAA------------------- EGSSVELD----------GSVVFSTS--GFVWSLPSGNLVMASILLRG---SSSSTGSTD SGTSDNGNTVTDGNTGTD-----------GDNGTDGNTGTDGNTGTDGNTGTDGSTDS-- -----------------------------------------------------------G NGGTLSVAYRIT--------------NNELVYSSES----------LSQAYSVNTTTGSL IVQSVTSSSSGS-AIGVTTGTYRLLTPRGTL----TFNL----AIDTNSTDGVAVSSNST ---------------TNTTVGAE------------------------------------- --AISGSGISTTAIYYI--------CLSAILFCIVCTF-----------LACVYIFRKGK KNKYKEAV---ATPK----------------------------AIKTY >XP_030827829.1 leucine-rich repeats and immunoglobulin-like domains protein 3 [Strongylocentrotus purpuratus] MATYSSQIFRCFYTVLVVYCLL--LDTAKYV-SGQNVL---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------CPEECWCLGSLV----DCSKRHLTSIPTDLPTWVTMLELQSNR IASIPDGTFDRLSQLEDLDLSSNKLRRLNASTFDGLSNLQQLKLASNKLTSLP--ILGPS ARNLTQLILHHNRITNISPAALRGLTSLRTLDLSYNRIGHLRTDTFPTDNRLQFLLLENN RISTLQQGCLNNLRSLEILKLN-------------------------------------- -------------------------------------------RNRIASLPRDLFTHLES LNLLELSRNELTTVDSLVFSGLESLEELSLSRNQLTDLMDGAFYGLNAIQQLELDGNELT TISRRWLFGL-KSLLHLTVAHNRINETEASGW----EFCPN------------------- --------LEYLDLSHNRLT-----------TLET------------------------- -----------------EEESVGE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------SGGPAAQG---------------- ----TSGGAPGSVG---VPP----------------------WPPLLRELYINHNRVTQV ADGAFIQLNLLQVLDLSDNVIAWTVDDMTGAFEGLESLLRLGLANNNINSISRRAFSGLV NLQSLDFAGNVITTVENNAFEGM--------PQLTQLLVNSSSMVCDCQMAWFPVWIKEN NLGEGVDGRCAHPDTLQGLDI--FSVDPEVFTCDDRLKPFIIREPETVTSLKNDNVSLIC TAGSTSDVQVTMLWKKDKAIMEDANPIYFERL-NPSGVNEYTSVLNLPHIKEADQGRFQC IISNEFGVTYSKKARVTVHIYPSFTVTPRHVSVRVGGIAELPCAATGHPTPKIAW-QKDG GINFPAARQRRIKVKTE---LAEFYIDNVQISDTGVYTCTALNAAGTI-STNATLTVLEP PLFTRQMKDLTVEVGEPAVL-ECNVEGSPRPSIRWFKDEEPFTLSDGMHLTDFDRYLIIM NAAGRD----------------GGTYT-------------------------CEATNSLG V----RTD---TAKL-VVTQNSGTVWNMTTTSIIIVVVICCILGTSLIWVVIIYHTRKRT SRYRVEESHHHVVPPEIPSSTLNGSSEGTIHQETSSGVSSAATDKYQDDNASDCDSLDGP VGKLSTFRFSNQVRMAAIFPSETKVIQPPELAPCPRQHHCNIQDGPHQS----GMERY-- ---------CPSDSLSEADRTTLERRGQLTALPCCNGTGRSLDSAINKHMYLHH-----G GGG--GRNHPLRKGGSDGEEGEIEEEDEDEVFMDEATRDRLQRERLLTNSDEGLGSQTAS PVNRHNYRRSNHPPPQCCHSYTSVSSPEGRCTSPSSFNIPHENAQRGDAYSRMAMSSSSL PCNGRIPNVHLYENPTSSTQDKDLIDGHLCRSHNHVNNVNNNSNTNHSPVADPIRQSHSI PTAISSTGNVSPGIGALLSPTTPPTTTHQVQNGHLHSHHRPHHPNRHNEKPTHQNSRKSG RHPEKHHVKSKTSPKSGQSIPRTSYLPSSNAHPAHHVTSPTLTSLTEA >CAA37910.1 slit protein [Drosophila melanogaster] ------------MAAPSRTTLM-----PPPFRLQLRLLIL-------------------- -----------------------------PILLLLRHDA-----VHAEPYSGGFGSSAVS SGGLG------SVGIH-------------------------------------------- ----------------------------IPGG---------------------------- --------GVGVITEARCPRVCSCTGLNV----DCSHRGLTSVPRKISADVERLELQGNN LTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLDISNNVITTVGRR-VFKG AQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTS-------------------- ----LPHNIFGGLGRLRALRLSDNPFACDCHLSWLSRFLRSATRLAPYTRCQSPSQLKGQ NVADLHDQEFKCSGLTEHAPMECGAENSCPHPCRCADGIVDCREKSLTSVPVTL---PDD TTDVRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIK DLPS----GVFKGLGSLRLLLLNANEISCIRK---DAF--------R------------- ----DLHSLSLLSLYDNNIQSLANGTFDAMKSMKTVHLAKNPFICDCNLRWLADYLHKNP IETSGARCESPKRMHRRRIESLREEKFKCSWGELRMKLSGECRMDSDCPAMCHCEGTTVD CTGRRLKEIPRD------IPLHTTELLLNDNELGRISSDGLFGRLPHLVKLELKRNQLTG IEPNAFEGASHIQELQLGENKIKEISNKMFLGLHQLKTLNLYDNQISCVMPGSFEHLNSL TSLNLASN--------PFNCNCHLAWFAECVRKKSLNGGAARCGAPSKVRDVQIKDLPHS EFKCSSENSEGCLGDGYCPPSCTCTGTVVACSRNQLKEIPRGIPAETSELYLESNEIEQI HYERIRHLRSLTRLDLSNNQITILSNYTFANLTKLSTLI---ISYNKLQCLQRHALSGLN NLRVVSLHGNRISMLPEGSFEDL--------KSLTHIALGSNPLYCDCGLKWFSDWIKLD YVEPGI-ARCAEPEQMKDKLI--LSTPSSSFVCRGRVRNDILAKCNACFE---------- ---------------------------------QPCQNQ--AQCVALP------QREYQC LCQPGY---HGKHCEFMID------------------------ACYGNPCR-----NNAT CTVLEEGR---FSCQCAPGYTGARCETNIDDCLGEIKCQNNATCIDGVESYKCECQ---P GFSGEFCDTKIQFCSPEFN--PCANGAKCMDHFTHYSCDCQAGFHGTNCTDNIDDCQNHM CQNGGTCVDGINDYQCRCPDDYTGKYCEGHNMISMMYPQTSPCQNHECKHGVCFQPNAQG SDYLCRCHPGYTGKWCEYLTSISFVHNNSFVELEPL------------------------ -RTRPEAN----------VTIVFSSAEQNGILMYDGQDAHLAVELFNGRIRVSYDVGNHP VSTMYSFEMVADGKYHAV-----------ELLAIKKNFTLRVDRGLARSIINEGSNDYLK LTTPMFLGGLPVDPAQQAYKNWQIR--NLTSFKGC-----------MKEVWINHKLVDFG N--A-QRQQKITPGCALLEGEQQEEEDDEQDFMDETPH---IKEEPVDPCLENKCRRGSR CVPN-SNARDGY-QCKCKHGQRGRYCDQG-----------------EGSTEPPTVTAAST ---------------CRKEQVREYYTENDCRS----------------------RQPLKY AKCVGGCGNQCCAAKIV--------RRRKVR--MVCSNNRKYIKNL--D-----IVRKCG CTK------------------------------------------KCY >XP_038059677.1 relaxin receptor 2-like isoform X1 [Patiria miniata] M--------HKLRNALRMLLIL-HVCAARRVKQDSALRHLQRRTVDAHKHCGVDFPCLNS TQCVPQDAICDGTPDCDNGSDEWEMEECRDLNLAKMWDD----FFGTKDESGEEEEDDVN QGLSPDPLPQRSFDAHGHCGEDFPCINSTQCVPQEAICNGEPDCDNGSDEWELEECRDWN LAKMWDDFFGDKAEDEDVRREIPCEKGTFPESCDCFVEIEETRKDLPSLASPFNATGDAS MGAGVDDVGTETNVTDGIPYGLGVQGVVVGVRLDCSARQLTEFPRNLPNKTISLDLSDNK ITSLTKKDMEHLTHLRQLLLSRNKLQNVEEGTFESLTDLQTLRMIACDLEDVPPR-MFAT QNRLVTLDLSYNILTRLVRGSLFGLHNLEYLDIRGNRLAE-------------------- ----IETGVFKDSSRIYFMHIS-------------------------------------- -------------------------------------------QNRLSSIPAELFRPLRD LRSLNIHRNDISSIECGSFSTNTKLRDLNLGDNKLTEIKRGLFHNLTSVITLSLRNNSIR HFEE----DAFAGMNNLQTLKLNQNPFTSVPI---GIF-DKLRSLKAIYFDHFSLCGYAP HVRLCMPKSDGISTAENLLA---------------------------------------- ------------------------------------------------------------ ------------------------------NNLLR------F------------------ ------------------------------------------------------------ ----------------AVWFVALLA----------------------------------- ----SLGNAF----------------------------------VLLARCFVKEDKKTHS FF-----IMNLAVADLLMGLYLLIIGIHDVIFRGVYILHDLAWRTSSVCKL-----SGFL SLLSSEVSIMTLTVITMDRFLSIVHPFRFKNRSLVHARLLMV-------LLWLL------ ----GV--ALATIPLLHTEYF-GEFYYGGNGVCLP---------------LQ-------- -------------------------------IDQPFANGWQFSLVIFVV--------FNL VAF--------------------------------------------------AFISYAY LMMFVTIRRSNLAMRSTKKNQDWALVKRFTLIVATDFVC------------------WMP IIIVKFVALGGVSVSNSVYA--------------WFAI---FVLPINSALNPI------- ------------------------------------------------------------ ------------------------LYTMTTVLF--------------------------- -KQKVLAP----------LGIVRAKRKKGYL----------------------------- -----------------------------TGISVDDTSTMSKNSGTRLSIISTKSR---- -----------------------------------------------------------G G----SVNGRFS-------SHKKLKNFDSLDSSDES---------VICTATKTTTKKRAV TVEY--------------------------------HQLP--V---SDSDERPLASTVT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------
BMGE Cleaned alignment of selected proteins >sp|Q9BXN1|ASPN_HUMAN Asporin OS=Homo sapiens OX=9606 GN=ASPN PE=1 SV=2 MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDEDNSLFPTREPRSHFFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLSRMSVQL >tr|Q1LXA7|Q1LXA7_DANRE Asporin OS=Danio rerio OX=7955 GN=aspn PE=3 SV=1 MKVLLLLALLTLCNAKPYKHINVMEFHDIMQQDAGDFDDDDDDDDKDYDD--------DNFVTDCPEGCRCSKKVLQCSDQGLTKVPKDIPANTLLLDLQNNDITEIKEDDFKGLDNLYALFLLNNQISKIHPKAFRNMNKLKILHLSYNLLTQMPENLPISVQSLRLHDNKISRLPKGAFKGMHDLNVLELSANPITNSGIDVGAFDDMATLYEAKLTAIPKDLPSSLNELHLDYNKIAKVESEDFLRLKGLQRLWLDFNQIKYVENGTFAATPKVREIHLDNNKLKKIPPNTLKYLQVMYLHANSIGYVGVNDFCPSRTRAKKTRISLYANPVKFRCVSSHNSVQL >NP_079987.2 asporin preproprotein [Mus musculus] MKEYVMLLLLAVCSAKPFFSPSHTALKNMMLKDMEDTDDDNDDDDNSLFPTKEPVNPFFDLFPTCPFGCQCYSRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIPSQELKYLQIIFLHYNSIAKVGVNDFCPTVPKMKKSAISLFNNPMKFRCVLGRMSVQL >XP_414298.2 asporin [Gallus gallus] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMLQDMEEE-DEDDDDDNSLFPTTEPIISLFDLFPTCPFGCQCYVRVVHCSDLGLTSIPRNIPPDTRMIDLQNNKIREVKENDLQGLASLYALALNNNKITKIHPKAFQPTKNLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNNDGIEPGAFEGVNIYHEAKLTSIPKDLPSSLLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLKKVPPPDLRYLQVVFLHSNHIAKLGVNDFCPTGRRKKKSGISLFNNPVKFRCILARNSVQL >NP_001029481.1 asporin precursor [Bos taurus] MKVYVLLVFLTLCSAKPLFHPSYLTLKNLMLKDMEDE--GDSDADNSLFPTREPINPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKATFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >XP_005616051.1 asporin [Canis lupus familiaris] MKECVFLVLLVLCSAKPSSRPSYMMLKNMMLKDTEDEMDGDPDDDNSLFPTREPINPFFDLFPTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTQMIDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPFNLPKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRIADIENGSLANIPRVREIHLENNKLKKIPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVRFRCVVSRMSVQL >XP_001146178.1 asporin [Pan troglodytes] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDEDNSLFPTREPRSHFFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPLDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLSRMSVQL >XP_002820006.1 asporin [Pongo abelii] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDEDNSLFPTREPRSSFFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLSRMSVQL >NP_001230818.1 asporin precursor [Sus scrofa] MKEYVLLLFLTLCSAKPLFRPSYMTLKNMMLKDMEEE--GDDDDDNSLFPTREPINPFFDLFPTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKIPSQELKYLQMIFLHSNSITKVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLGRMSVQL >XP_003210079.1 asporin [Meleagris gallopavo] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMLQDMEEE-DEDDDDDNSLFPTTEPIIPLFDLFPTCPFGCQCYVRVVHCSDLGLTSIPRNIPPDTRMIDLQNNKIREVKENDLQGLTTLYALALNNNKITKIHPKAFQPTKKLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIPKDAFKGMKSLHVLEMSANPLNNDGIEPGAFEGVNIYHEAKLTSIPKDLPSTLLELHLDDNKITAVELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLKKVPPPDLKYLQVVFLHSNHIAKLGVNDFCPTGRRKKKSGISLFNNPVKFRCILARNSVQL >XP_003807889.1 asporin [Pan paniscus] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDEDNSLFPTREPRSHFFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPLDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLSRMSVQL >XP_003995354.1 asporin [Felis catus] MKGCVLLVLLALCSAKPLFHPSYVTLKNMMLKDMEDEGDSDLDADNSLFPTREPINPFFDLFPTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTQMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPFNLPKSLAELRIHDNKVKKIQKETFKGMNTLHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKIPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLFNNPVRFRCVVGRMSVQL >XP_004004126.1 asporin [Ovis aries] MKEYVLLVFLTLCSAKPLFHPSYMTLKNLMLKDMEDE--GDSDADNSLFPTREPINPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >XP_004048312.2 asporin [Gorilla gorilla gorilla] MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDEDNSLFPTREPRSHFFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSAISLFNNPVKFRCVLSRMSVQL >XP_004086170.1 asporin [Oryzias latipes] MRVLLLLCLLSFGKTKPYQPVNVMDLHDIMIADS---DEDDDEEDDDYDD------------EDCPANCRCSPQVVQCSDQGLISVPEKIPEDTMMIDLQNNDITEIKEDDFKGLHKLYGLFLINNRISKVHPNAFKNMDHLRLLYLSYNLLTEIPANLPPNVIELRFYENNINRIQKNAFDGLRKLHVLELGANPLANSGIEVGAFNGLSTLYEAKLTSVPKDLPSSIKELSLDYNKIAKVEVEDFIRYKNLQRLGLAFNQIKFVENGSLIRIPNIHEIHLDHNRLKKVPPNSLRYLQVIFLHNNKISYVGMNDFCPSSTGGKKTGISLFANPVKFRCVTGRRAVHL >XP_005508936.1 asporin [Columba livia] MKEYTLLLFLALCSAKPLIGPSYFTLKNMMVQDMEEE-DDDDDDDNSLFPTTEPMIPLFDLFPTCPFGCQCYVRVVHCSDLGLTSIPRYIPPDTRMIDLQNNKIKEVKEKDLQGLTSLYALALNNNKITKIHPKAFQSTQKLRRLYLSHNQLTEIPTNLPKTLAELRIHANKVKKIHKDVFKGMKSLHVLEMSANPLDNDGIEPGAFEGVNIYHEAKLTSIPKDLPSSLLELHLDDNKITAIELEDFNRYKDLQRLGLGNNKIKDVENGSFANIPSIREIHLEKNKLKKVPPPELKYLQVVFLHSNHIAKLGVNDFCPTGRRKKKSGISLFNNPVKFRCILARNSVQL >XP_005684219.1 PREDICTED: asporin [Capra hircus] MKEYVLLVFLTLCSAKPLFHPSYMTLKNLMLKDMEDE--GDSDADNSLFPTREPINPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >XP_006025942.1 asporin isoform X1 [Alligator sinensis] MKEYVLLLFFALCSAKPLIGPSYFTLKNMMLQDMEDA--DDDDDDNSLFPTREPILPLFDIFPVCPFGCQCYMRVVHCSDLGLTSIPSNIPPDTRMIDLQNNKIKEVKENDLKGLTSLYALALNNNKISKIHPKAFQSTKKLRRLYLSHNQLTEIPDNLPKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDNAGIEPGAFEGVTIYHEAKLTSVPKELPSSLLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPSLREIHLERNKLKKVPPPYLKYLQVVFLHNNNIPKVGINDFCPTERSMKKSGISLFNNPMKFRCILSANSVQL >XP_006261182.1 PREDICTED: asporin isoform X1 [Alligator mississippiensis] MKEYVLLLFFALCSAKPLIGPSYFTLKNMMLQDMEDA-DDDDDDDNSLFPTREPILPLFDIFPVCPFGCQCYMRVVHCSDLGLTSIPSNIPPDTRMIDLQNNKIKEVKENDLKGLTSLYALALNNNKISKIHPKAFQPTKKLRRLYLSHNQLTEIPDNLPKSLAELRIHANKVKKIHKEAFKGMKSLHVLEMSANPLDNAGIEPGAFEGVTIYHEAKLTSVPKELPSSLLELHLDDNKISMIELEDFIRYKDLQRLGLGNNKIKDVENGSLANIPSLREIHLERNKLKKVPPPYLKYLQVVFLHNNNIPKVGINDFCPTERSMKKSGISLFNNPMKFRCILSANSVQL >XP_008255097.1 PREDICTED: LOW QUALITY PROTEIN: asporin [Oryctolagus cuniculus] MKESVFLLLLALCSAKPLLSPSHLTLKNMMLKDMEDMDDDDNDDDNSVFPTKETVHPFFDLFPTCPFGCQCYSRVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGXTVFHEAKLTSIPKELPSTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNRISDIENGSFANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTMPKMKKSAISLSNNPVNFRCVLSRMSVQL >XP_015813771.1 PREDICTED: asporin [Nothobranchius furzeri] MKVLLLFCLLTLGSSKPYQPINIMDLYDIMMADS-----DEDEDDDDYDD------------EDCPAHCRCSPGVVQCSDQGLISVPEKIPEDTVMIDLQNNDITEIQEDDFKGLNKLYGLFLNNNKISKIHPKAFRNMDHLRLLYLSYNLLTEIPANLPPNIIELRFHENNINRIQKDAFKGLRKLHVLELGANPLANSGMELGSFNGLSTLYEAKLTEVPKDLPASITELSLDYNKISKVEVEDLMRYKNLKRLGLGFNQIRSVENGSFTSIPNIHEIHLNHNRLKKVPPGSLRFLQAIFLHGNKISNVGFNDFCPKSVSIKKSAISLFANPVKFRCVISRRGVQL >KAB0347446.1 hypothetical protein FD754_012303 [Muntiacus muntjak] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDE--GDSDADNSLFPTREPVNPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRLIDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKGLPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >XP_043309693.1 asporin [Cervus canadensis] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDE--GDSDADNSLFPTREPVNPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRLVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKDLPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >KAB0373557.1 hypothetical protein FD755_015216 [Muntiacus reevesi] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDE--GDSDADNSLFPTREPVNPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRLIDLQNNKIKEIKENDFKGLTSLYALILNNNKLSKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKDLPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >NP_001014030.1 asporin precursor [Rattus norvegicus] MKEYMMLLLLAVCSAKPFFSPSHTALKTMMLKDMEDTDNDDDDDDNSLFPTKEPVNPFFDLFPTCPFGCQCYSRVVHCSDLGLTSVPSNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPRSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKGLPPTLLELHLDFNKISTVELEDFKRYKELQRLGLGNNKITDIENGTFANIPRVREIHLEHNKLKKIPSQELKYLQIIFLHNNSITKVGVNDFCPTVPKMKKSAISLFNNPMKFRCVVGRMSVQL >NP_001088205.1 asporin L homeolog [Xenopus laevis] MKEYLLFYFLALCYAKPFLPPKYMALTDLMLKDMEDDDDDNDDDDNSLFPFKKPVRPTFDLFPSCPFGRQCYLKIVQCSDLGLTSIPNKIPYDTRLLDLQNNKIKEIKEKDLQGLTSLSALFLNNNKLYKVHPKAFQSTKKLRRLYLSHNQLTEIPSNLPKSLAEIRIHDNKVKKVQKEAFKGIHSLHVLEMSANPLESEGIEPGAFDGLTVFHDAKLTSIPKDLPTSIYQLHLDHNKISGIELEDLLRYKELQRLGLGHNKIKDVENGSFASIPNVREIHLENNKLRRVPPADLKYLQVLFLHSNNIGKVDVNDFCPTGLKLKKSGISLFKNPVKFRCTLGRNSVHL >XP_040178826.1 biglycan [Rana temporaria] MKVLLLICTSLLCNALPFEQRGFWDFMDDGLTMMRDEANEEGSGFSTATPGKKPTA--MPPMDLCPFGCQCHLRVVQCSDLGLTSVPKNIPKDTMLLDLQNNKIMEIKKDDLKGLSKLYALVLVNNKISKVNEKAFEPCSNLQKLYISKNSLEEIPKSLPKSLVELRIHENKIKKIPKDVFNGLKNMNCIELGGNPLENGGIDAGAFNGLKLNYEAKLSGIPKGLPASLNELHLDHNRIQAVEMGDLSTLPNLYRLGLGYNIIRQVENGSLSSLPILRELHLDNNKLAKVPPPDLKFLQVVYLHSNNITQVGVNDFCPTGFGVKRNGISLFNNPVPFRCVTDRLAIQF >XP_020738805.1 asporin [Odocoileus virginianus texanus] MKEYVLLVFLTLCSAKPLFHPSYMTLKNMMLKDMEDE--GDSDADNSLFPTREPVNPFFDLFSTCPFGCQCYSRVVHCSDLGLSSVPSNIPFDTRLVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKETFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHEAKLTSIPKELPSTLLELHLDYNKISVVELEDFKRYKDLQRLGLGNNRITDIENGSLANIPRVREIHLENNKLKKVPSQELKYLQIIFLHSNSITKVGVNDFCPTVPKMKKSAISLSNNPVKFRCVLSRMSVQL >XP_030276561.1 asporin [Sparus aurata] MRVFLLLCLLALGNAKPYQPINVMDFFDIMMADAGDDDDDDDDDDDDYDD------------ENCPAGCRCSPGVVQCSDQGQISVPEKIPEDTLLLDLQNNDITEIKEDDFKGLNRLYGLFLINNKISKIHPRAFRNMERLKLLYLSYNLLTEIPANLPPNVIELRFHENKINKIQKDAFKGLRKLHVLELGANPLANSGIELGAFNGLSSLYEAKLTAVPKDLPNAITELNLDYNKIGKVEVEDFIRYKNLLRLRLGFNQIKSVENGSFVSIPNVREIHLDNNRLRKVPPNSLRYLQVIFLHGNKISNVGVNDFCPIRASVKKTGISLFANPVKFRCVTGRRGVQL >XP_039255120.1 slit homolog 1 protein-like [Styela clava] KREKKLTCVL---NSKSSLGPSFLIRTKMNPIKMDYSTTRGGKSHSSLTSLIL-----ADLSTACPSMCTCASTSVDCTHQSLSSIPAGIPTDTVTLDMRNNQIATLSADAFAGLTSLEKLYLDTIQLVTIESGAFNGLTALKELTMTANSITALPSSLGSTLIKIDLKSNQLNTLSASTFSGLTNLETLDLSSNQLTT--LPANVFSDLSTLTSNKLASIPTDSLTSLPLLKLDSNLITSMDAGVLAPLTSLTKVSLVGNSLTTVPTGVFVDHSTLQEIDLQDNQITVLSSSNLADIRVIKLRSNQISSVGVHAFFNIKATLRQEIIDLSQNQITLPCVSSGSSVEL >XP_030827829.1 leucine-rich repeats and immunoglobulin-like domains protein 3 [Strongylocentrotus purpuratus] YTVLVVYCLL-LDTAKYVSGQNVL----------------------------------------CPEECWCLGSLVDCSKRHLTSIPTDLPTWVTMLELQSNRIASIPDGTFDRLSQLEDLDLSSNKLRRLNASTFDGLSNLQQLKLASNKLTSLPGPSARNLTQLILHHNRITNISPAALRGLTSLRTLDLSYNRIGHSTLQQGCLNNLRSLERNRIASLPRDLLESLNLLELSRNELTTVDSLVFSGLESLEELSLSRNQLTDLMDGAFYGLNAIQQLELDGNELTTISRKSLLHLTVAHNRINETEASGW-EFCPN------EYLDLSHNRLTFQCIISRYRVEE >CAA37910.1 slit protein [Drosophila melanogaster] MAAPSRTTLM----PPPFLQLRLLIL-PILLLLRHDAPYSGGFGSSAVSSGGLSVGIHVITEARCPRVCSCTGLNVDCSHRGLTSVPRKISADVERLELQGNNLTVIYETDFQRLTKLRMLQLTDNQIHTIERNSFQDLVSLERLDISNNVITTVGFKGAQSLRSLQLDNNQITCLDEHAFKGLVELEILTLNNNNLTS--LPHNIFGGLGRLREKSLTSVPVTLPDDTTDVRLEQNFITELPPKSFSSFRRLRRIDLSNNNISRIAHDALSGLKQLTTLVLYGNKIKDLPSKGLGSLRLLLLNANEISCIRKDAF--------RSLLSLYDNNIQYQCLCQRTRPEA >XP_038059677.1 relaxin receptor 2-like isoform X1 [Patiria miniata] RNALRMLLILHVCAARRVQDSALRHLRDLNLAKMWDDDESGEEEEDDVNQGLSSFDAHTNVTDGIPYGLGVQGVVVDCSARQLTEFPRNLPNKTISLDLSDNKITSLTKKDMEHLTHLRQLLLSRNKLQNVEEGTFESLTDLQTLRMIACDLEDVPFATQNRLVTLDLSYNILTRLVRGSLFGLHNLEYLDIRGNRLAE--IETGVFKDSSRIYQNRLSSIPAELLRDLRSLNIHRNDISSIECGSFSTNTKLRDLNLGDNKLTEIKRGLFHNLTSVITLSLRNNSIRHFEEAGMNNLQTLKLNQNPFTSVPIGIF-DKLRSLKADGISTAENLLAFNLVAFKQKVLA
PhyML tree of selected proteins (XP_004004126_1_asporin__Ovis_aries_:0.00000001,XP_005684219_1_PREDICTED__asporin__Capra_hircus_:0.00000001,((((((((((((XP_039255120_1_slit_homolog_1_protein_like__Styela_clava_:1.0365384,XP_030827829_1_leucine_rich_repeats_and_immunoglobulin_like_domains_protein_3__Strongylocentrotus_purpuratus_:1.13706534):0.26952237,XP_038059677_1_relaxin_receptor_2_like_isoform_X1__Patiria_miniata_:1.41693948):0.24420559,CAA37910_1_slit_protein__Drosophila_melanogaster_:1.54411786):0.75200448,(tr_Q1LXA7_Q1LXA7_DANRE_Asporin_OS_Danio_rerio_OX_7955_GN_aspn_PE_3_SV_1:0.30189224,((XP_004086170_1_asporin__Oryzias_latipes_:0.11790859,XP_015813771_1_PREDICTED__asporin__Nothobranchius_furzeri_:0.11313377):0.06096977,XP_030276561_1_asporin__Sparus_aurata_:0.06255444):0.12486585):0.19813484):0.07281593,XP_040178826_1_biglycan__Rana_temporaria_:0.58890411):0.1944412,NP_001088205_1_asporin_L_homeolog__Xenopus_laevis_:0.17994902):0.08520116,(((XP_414298_2_asporin__Gallus_gallus_:0.01224353,XP_003210079_1_asporin__Meleagris_gallopavo_:0.00601315):0.01893947,XP_005508936_1_asporin__Columba_livia_:0.02106849):0.0519932,(XP_006025942_1_asporin_isoform_X1__Alligator_sinensis_:0.00000001,XP_006261182_1_PREDICTED__asporin_isoform_X1__Alligator_mississippiensis_:0.00298137):0.07554008):0.06996851):0.12373235,(((((XP_001146178_1_asporin__Pan_troglodytes_:0.00000001,XP_003807889_1_asporin__Pan_paniscus_:0.00000001):0.00295257,(sp_Q9BXN1_ASPN_HUMAN_Asporin_OS_Homo_sapiens_OX_9606_GN_ASPN_PE_1_SV_2:0.00000001,XP_004048312_2_asporin__Gorilla_gorilla_gorilla_:0.00000001):0):0.00296207,XP_002820006_1_asporin__Pongo_abelii_:0.00000001):0.05037781,(NP_079987_2_asporin_preproprotein__Mus_musculus_:0.02119474,NP_001014030_1_asporin_precursor__Rattus_norvegicus_:0.01858433):0.03299924):0.01453152,XP_008255097_1_PREDICTED__LOW_QUALITY_PROTEIN__asporin__Oryctolagus_cuniculus_:0.05302784):0.01010266):0.02045848,NP_001230818_1_asporin_precursor__Sus_scrofa_:0.01374033):0.01293312,(XP_005616051_1_asporin__Canis_lupus_familiaris_:0.03502204,XP_003995354_1_asporin__Felis_catus_:0.01863575):0.02608796):0.01396278,(((KAB0347446_1_hypothetical_protein_FD754_012303__Muntiacus_muntjak_:0.00293572,KAB0373557_1_hypothetical_protein_FD755_015216__Muntiacus_reevesi_:0.00292014):0.00291482,XP_043309693_1_asporin__Cervus_canadensis_:0.00000001):0.00291773,XP_020738805_1_asporin__Odocoileus_virginianus_texanus_:0.00000001):0.00580877):0.0029482,NP_001029481_1_asporin_precursor__Bos_taurus_:0.00881172):0.00000001);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)