PB0179

DATABASE

Click here to access PB0179 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0179	P02649	Apolipoprotein E	APOE	AD2, APO-E, ApoE4, LDLCQ5, LPG	Homo_sapiens	This interaction is probably promoted via the up-regulation of cellular autophagy by the virus (PubMed:29695434).

Domains

Gene Ontology

PF01442 (Apolipoprotein)

GO:0048662 (acts upstream of) negative regulation of smooth muscle cell proliferation GO:0060999 (acts upstream of or within) positive regulation of dendritic spine development GO:1902952 (acts upstream of or within) positive regulation of dendritic spine maintenance GO:0097113 (acts upstream of or within positive effect) AMPA glutamate receptor clustering GO:0097114 (acts upstream of or within positive effect) NMDA glutamate receptor clustering GO:0001540 (enables) amyloid-beta binding GO:0005102 (enables) signaling receptor binding GO:0005198 (enables) structural molecule activity GO:0005319 (enables) lipid transporter activity GO:0005515 (enables) protein binding GO:0005543 (enables) phospholipid binding GO:0008201 (enables) heparin binding GO:0008289 (enables) lipid binding GO:0016209 (enables) antioxidant activity GO:0042802 (enables) identical protein binding GO:0042803 (enables) protein homodimerization activity GO:0043395 (enables) heparan sulfate proteoglycan binding GO:0044877 (enables) protein-containing complex binding GO:0046911 (enables) metal chelating activity GO:0046983 (enables) protein dimerization activity GO:0048156 (enables) tau protein binding GO:0050750 (enables) low-density lipoprotein particle receptor binding GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity GO:0070326 (enables) very-low-density lipoprotein particle receptor binding GO:0071813 (enables) lipoprotein particle binding GO:0120020 (enables) cholesterol transfer activity GO:0000302 (involved in) response to reactive oxygen species GO:0001937 (involved in) negative regulation of endothelial cell proliferation GO:0002021 (involved in) response to dietary excess GO:0006629 (involved in) lipid metabolic process GO:0006641 (involved in) triglyceride metabolic process GO:0006707 (involved in) cholesterol catabolic process GO:0006869 (involved in) lipid transport GO:0006874 (involved in) cellular calcium ion homeostasis GO:0006898 (involved in) receptor-mediated endocytosis GO:0006979 (involved in) response to oxidative stress GO:0007010 (involved in) cytoskeleton organization GO:0007186 (involved in) G protein-coupled receptor signaling pathway GO:0007263 (involved in) nitric oxide mediated signal transduction GO:0007271 (involved in) synaptic transmission, cholinergic GO:0007616 (involved in) long-term memory GO:0008202 (involved in) steroid metabolic process GO:0008203 (involved in) cholesterol metabolic process GO:0010467 (involved in) gene expression GO:0010468 (involved in) regulation of gene expression GO:0010544 (involved in) negative regulation of platelet activation GO:0010596 (involved in) negative regulation of endothelial cell migration GO:0010629 (involved in) negative regulation of gene expression GO:0010873 (involved in) positive regulation of cholesterol esterification GO:0010875 (involved in) positive regulation of cholesterol efflux GO:0010877 (involved in) lipid transport involved in lipid storage GO:0010976 (involved in) positive regulation of neuron projection development GO:0010977 (involved in) negative regulation of neuron projection development GO:0015909 (involved in) long-chain fatty acid transport GO:0017038 (involved in) protein import GO:0019068 (involved in) virion assembly GO:0019934 (involved in) cGMP-mediated signaling GO:0030195 (involved in) negative regulation of blood coagulation GO:0030516 (involved in) regulation of axon extension GO:0031175 (involved in) neuron projection development GO:0032269 (involved in) negative regulation of cellular protein metabolic process GO:0032489 (involved in) regulation of Cdc42 protein signal transduction GO:0032805 (involved in) positive regulation of low-density lipoprotein particle receptor catabolic process GO:0033344 (involved in) cholesterol efflux GO:0033700 (involved in) phospholipid efflux GO:0034372 (involved in) very-low-density lipoprotein particle remodeling GO:0034374 (involved in) low-density lipoprotein particle remodeling GO:0034375 (involved in) high-density lipoprotein particle remodeling GO:0034380 (involved in) high-density lipoprotein particle assembly GO:0034382 (involved in) chylomicron remnant clearance GO:0034384 (involved in) high-density lipoprotein particle clearance GO:0034447 (involved in) very-low-density lipoprotein particle clearance GO:0035641 (involved in) locomotory exploration behavior GO:0042157 (involved in) lipoprotein metabolic process GO:0042158 (involved in) lipoprotein biosynthetic process GO:0042159 (involved in) lipoprotein catabolic process GO:0042311 (involved in) vasodilation GO:0042632 (involved in) cholesterol homeostasis GO:0042981 (involved in) regulation of apoptotic process GO:0042982 (involved in) amyloid precursor protein metabolic process GO:0043254 (involved in) regulation of protein-containing complex assembly GO:0043407 (involved in) negative regulation of MAP kinase activity GO:0043524 (involved in) negative regulation of neuron apoptotic process GO:0043537 (involved in) negative regulation of blood vessel endothelial cell migration GO:0043691 (involved in) reverse cholesterol transport GO:0044794 (involved in) positive regulation by host of viral process GO:0045088 (involved in) regulation of innate immune response GO:0045541 (involved in) negative regulation of cholesterol biosynthetic process GO:0045807 (involved in) positive regulation of endocytosis GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0046889 (involved in) positive regulation of lipid biosynthetic process GO:0046907 (involved in) intracellular transport GO:0048168 (involved in) regulation of neuronal synaptic plasticity GO:0048844 (involved in) artery morphogenesis GO:0050709 (involved in) negative regulation of protein secretion GO:0050728 (involved in) negative regulation of inflammatory response GO:0050807 (involved in) regulation of synapse organization GO:0051000 (involved in) positive regulation of nitric-oxide synthase activity GO:0051044 (involved in) positive regulation of membrane protein ectodomain proteolysis GO:0051246 (involved in) regulation of protein metabolic process GO:0051651 (involved in) maintenance of location in cell GO:0055088 (involved in) lipid homeostasis GO:0055089 (involved in) fatty acid homeostasis GO:0061136 (involved in) regulation of proteasomal protein catabolic process GO:0061771 (involved in) response to caloric restriction GO:0070328 (involved in) triglyceride homeostasis GO:0070374 (involved in) positive regulation of ERK1 and ERK2 cascade GO:0071830 (involved in) triglyceride-rich lipoprotein particle clearance GO:0071831 (involved in) intermediate-density lipoprotein particle clearance GO:0072359 (involved in) circulatory system development GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:0090181 (involved in) regulation of cholesterol metabolic process GO:0090209 (involved in) negative regulation of triglyceride metabolic process GO:0097006 (involved in) regulation of plasma lipoprotein particle levels GO:0098869 (involved in) cellular oxidant detoxification GO:0120009 (involved in) intermembrane lipid transfer GO:1900221 (involved in) regulation of amyloid-beta clearance GO:1900223 (involved in) positive regulation of amyloid-beta clearance GO:1900272 (involved in) negative regulation of long-term synaptic potentiation GO:1902430 (involved in) negative regulation of amyloid-beta formation GO:1902991 (involved in) regulation of amyloid precursor protein catabolic process GO:1902995 (involved in) positive regulation of phospholipid efflux GO:1903002 (involved in) positive regulation of lipid transport across blood-brain barrier GO:1905855 (involved in) positive regulation of heparan sulfate binding GO:1905860 (involved in) positive regulation of heparan sulfate proteoglycan binding GO:1905890 (involved in) regulation of cellular response to very-low-density lipoprotein particle stimulus GO:1905906 (involved in) regulation of amyloid fibril formation GO:1905907 (involved in) negative regulation of amyloid fibril formation GO:1905908 (involved in) positive regulation of amyloid fibril formation GO:2000822 (involved in) regulation of behavioral fear response GO:0043083 (is active in) synaptic cleft GO:0098978 (is active in) glutamatergic synapse GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005769 (located in) early endosome GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0005794 (located in) Golgi apparatus GO:0005886 (located in) plasma membrane GO:0016020 (located in) membrane GO:0030425 (located in) dendrite GO:0030669 (located in) clathrin-coated endocytic vesicle membrane GO:0031012 (located in) extracellular matrix GO:0043025 (located in) neuronal cell body GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:0071682 (located in) endocytic vesicle lumen GO:0072562 (located in) blood microparticle GO:1903561 (located in) extracellular vesicle GO:0034361 (part of) very-low-density lipoprotein particle GO:0034362 (part of) low-density lipoprotein particle GO:0034363 (part of) intermediate-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0034365 (part of) discoidal high-density lipoprotein particle GO:0042627 (part of) chylomicron GO:1990777 (part of) lipoprotein particle

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH >sp|O42364|APOEB_DANRE Apolipoprotein Eb OS=Danio rerio OX=7955 GN=apoeb PE=2 SV=1 MRSLVVFFALAVLTGCQARSLFQADAPQPRWEEMVDRFWQYVSELNTQTDGMVQNIKGSQ LSRELDTLITDTMAELSSYSENLQTQMTPYASDAAGQLSKDLQLLAGKLQTDMTDAKERS TQYLQELKTMMEQNADDVKNRVGTYTRKLKKRLNKDTEEIRNTVATYMSEMQSRASQNAD AVKDRFQPYMSQAQDGATQKLGAISELMKAQAQEVSEQLEVQAGALKEKLEETAENLRTS LEGRVDELTSLLAPYSQKIREQLQEVMDKIKEATAALPTQA >tr|Q503V2|Q503V2_DANRE Apolipoprotein Ea OS=Danio rerio OX=7955 GN=apoea PE=2 SV=1 MKFVAVIVALAVISGCQGRFLFQDEPRSRWEEAVDQFWNHVSELTTRAEEMRDNIKATQL GRELDTLISDSMMELQMYRDDLHSKLAPYAQERAQKFNEDLQLLVTKLRTHMEEAKDRVT EYTEELRTMVEQNSDELKNKANSYAKKLRKRFNKDIQEINKKMSTYLEEVQSRASQSVED VKDRLEPYFTSMHERAQQKLVNLREALRSQAEEIKERLDSRMQELRDQVEKTKENVHNTL QQKAEDVQKWFEPYVSHIQKQMEPVWESL
Selected proteins from model organisms >sp|P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEK VQAAVGTSAAPVPSDNH >sp|O42364|APOEB_DANRE Apolipoprotein Eb OS=Danio rerio OX=7955 GN=apoeb PE=2 SV=1 MRSLVVFFALAVLTGCQARSLFQADAPQPRWEEMVDRFWQYVSELNTQTDGMVQNIKGSQ LSRELDTLITDTMAELSSYSENLQTQMTPYASDAAGQLSKDLQLLAGKLQTDMTDAKERS TQYLQELKTMMEQNADDVKNRVGTYTRKLKKRLNKDTEEIRNTVATYMSEMQSRASQNAD AVKDRFQPYMSQAQDGATQKLGAISELMKAQAQEVSEQLEVQAGALKEKLEETAENLRTS LEGRVDELTSLLAPYSQKIREQLQEVMDKIKEATAALPTQA >tr|Q503V2|Q503V2_DANRE Apolipoprotein Ea OS=Danio rerio OX=7955 GN=apoea PE=2 SV=1 MKFVAVIVALAVISGCQGRFLFQDEPRSRWEEAVDQFWNHVSELTTRAEEMRDNIKATQL GRELDTLISDSMMELQMYRDDLHSKLAPYAQERAQKFNEDLQLLVTKLRTHMEEAKDRVT EYTEELRTMVEQNSDELKNKANSYAKKLRKRFNKDIQEINKKMSTYLEEVQSRASQSVED VKDRLEPYFTSMHERAQQKLVNLREALRSQAEEIKERLDSRMQELRDQVEKTKENVHNTL QQKAEDVQKWFEPYVSHIQKQMEPVWESL >NP_033826.2 apolipoprotein E precursor [Mus musculus] MKALWAVLLVTLLTGCLAEGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQEL TALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQST EEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAA QPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVE DMHRQWANLMEKIQASVATNPIITPVAQENQ >NP_620183.2 apolipoprotein E precursor [Rattus norvegicus] MKALWALLLVPLLTGCLAEGELEVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQEL TVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQST EELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAA QPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVE DMQRQWANLMEKIQASVATNSIASTTVPLENQ >XP_005219205.2 apolipoprotein E isoform X1 [Bos taurus] MRDSENPLLLPFIEHLLGAHNRPKIGWPIASQKMKVLWVAVVVALLAGCQADMEGELGPEEPLTTQQPRG KDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTALMEETMKEVKAYKEELEGQLGPMAQETQ ARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLA VYQAGASEGAERSLSAIRERFGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLD KIRQQLEEVHAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPSPTSPPSENH >NP_999473.1 apolipoprotein E precursor [Sus scrofa] MRVLWVALVVTLLAGCRTEDEPGPPPEVHVWWEESKWQGSQPWEQALGRFWDYLRWVQSLSDQVQEELLS TKVTQELTELIEESMKEVKAYREELEAQLGPVTQETQARLSKELQAAQARVGADMEDVRNRLVLYRSEVH NMLGQTTEELRSRLASHLRNVRKRLVRDTEDLQKRLAVYQAGLREGAERSVSALRERLGPLVEQGRLRAA TLSTRAGQPLRERAEAWGQKLRGRLEEMGSRTRDRLDEMRDELEEVRTKVEEQGSQLRLQAEAFQARLKG WFEPLVEDMRRQWAGLVERMQSAVSISSSTSAPSDNQ >NP_001009007.1 apolipoprotein E precursor [Pan troglodytes] MKVLWAALLVTFLAGCQAKVEQVVETEPEPELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELL SSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEV QAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRA ATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK SWFEPLVEDMQRQWAGLVEKVQAAMGTSAAPVPSDNH >XP_533644.1 apolipoprotein E [Canis lupus familiaris] MKVLWAALVVTLLAGCWADVQPEPELERELEPKVQQELEPEAGWQTGQPWEAALARFWDYLRWVQTLSDQ VQEGVLNTQVTQELTALMDETMKEVKAYKAELDEQLGPMTSETQARVAKELQAAQARLRSDMEDVRNRLT QYRGELQAMLGQSSEELRARFASHMRKLRKRVLRDAEDLQRRLAVYKAGVREGAERSVSSIRERLWPLLE QARERNAKVGALATQPLLERADALGQQLRGQLEEMSSRARGHLEEMREQIQEVRVKMEEQADQIRQKAEA FQARLKSWFEPLLEDMQRQWDGLVEKVQAAVATIPTSKPVEEP >NP_001076112.1 apolipoprotein E precursor [Oryctolagus cuniculus] MKVWWAVLAAAILAGCRAQTEQEVEVPEQARWKAGQPWELALGRFWDYLRWVQSLSDQVQEELLSSQVTQ ELTMLMEETMKEVKAYKSELEEQLSPMAQEHRARLSKELQVAGALEADMEDVCNRLAQYRGEAQAMLGQS TEELARAFSSHLRKLRKRLLRDAEDLQKRMAVYGAGAREGAERGVSAVRERLGSRLERGRLRVATVGTLA GRPLRERAQAWGERLRGHLEEVGSRARDRLNEVREQVEEVRVKVEEQAPQMRLQAEAFQARLKSWFEPLV EDMQRQWAGLVEKLQAAMPSKAPAAAPIENQ >XP_002829425.2 apolipoprotein E [Pongo abelii] MKVLWAALLVTFLAGCQANVEQVVEPEPEPELRQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELL NSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEV QAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRA ATVGSVAGKPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLK SWFEPLVEDMQRQWAGLVEKVQAAVGTSAAPVPSDNH >XP_008969013.3 LOW QUALITY PROTEIN: apolipoprotein E [Pan paniscus] MSSGASRKCSWDLGKPWPPDWPITGRKMKVLWAALLVTFLAGCQAKVEQVVETEPEPELHQQAEWQSGQR WELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSK ELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAG AREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQ VAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTSAAPVPSDNH >XP_023101561.1 apolipoprotein E [Felis catus] MKVLWAALLVALLAGCWADVEPEPQLERELEPEAPWQASQPWEQALGRFRDYLRWVQTLSDQVQEEVLNT QVTQELTVLMEETMKEVKAYREELEEQLGPMASETQARVAKELQAAQARLGSDMEDVRNRLAQYRSEVQA MLGQSAEELRGRLASHLRKLRKRLLRDAEDLHKRLAVYRAGVREGAERSVSSIRERFWPLVEQARARNAN VAAVAAQPLRERAEALGQQLRGRLDEVREQVAEMRVKMEEQADQMRQQAEAFQARLKSWFEPLVQDMQRQ WAGLVEKLQAAVGTSPTTAPVEKQ >XP_027834259.1 apolipoprotein E [Ovis aries] MKVLWVALVVALLAGCQADMEGELGSEEPLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLN TQVIQELTVLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQ AMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLRPLVEQSQSRAA TLSTQVGQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRSKVEEQGSQIRLQAEAFQARLRS WFEPLVEDMQRQWAGLVEKVQLALHLSPTSPPSENH >XP_030863288.1 LOW QUALITY PROTEIN: apolipoprotein E [Gorilla gorilla gorilla] MSSGASRKMSWDLGKPWPPDWPITGRKMKVLWAALLVTFLAGCQAKVEQAVETEPEPELHQQAEWQSGQR WELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSK ELQAAQARLGADMEDVRGRLAQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAG AREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQ VAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTSAAPVPSDNH >XP_023815792.1 apolipoprotein Eb [Oryzias latipes] MRVFAVILALAVLSGCHSRTVPLEDLKNTWEVTVEKFQDYITDLNTKADGVLENIRSSQISRELETLIQD SMSELSMYKDDLETKLHPFTQQRAERLRQDLQLMADKLREHMKEAREQVDRYVQELQTMMEQNADDVKLR VSTYSRKLKKRLTKDTQEIKRYVSEYFEELHSRTSENVEELKARLDPYFSQVRDNAQAKISTLNELLQSQ IENVKTRMQTTHEDVKERVKVAAEELRSGVETRMQELRNWFQPYVSMVRESL >XP_017918050.1 PREDICTED: apolipoprotein E [Capra hircus] MKVLWVALVVALLAGCQADMEGELGSEEPLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLN TQVIQELTVLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQ AMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLRPLVEQGQSRAA TLSTQAAQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGSQIRLQAEAFQARLRS WFEPLVGDMQRQWAGLVEKVQLALHLSPTSPPSENH >XP_006038593.1 apolipoprotein E isoform X1 [Alligator sinensis] MRVWTVLLGAVLLLAACQAEETKAKWEETVEVFREYVNRLSLATDDITEQITSSQMGKEMDMLIKDMVAE LQAYRKDVEERLGPHAVVMRERLHTDVTVLGERLRVDMEEAKTRVQQYLGEARQVAGQNLEDVRSRVGTY LRKLRKRLAKDTEELRRKLEAYSAEATRHLETVREDLEPLREKGQQRLAALQQALRDQGQRLREQLEVRA QDMRGSLDRAATQLQEWLEPFLADIRTQMQGLLDKLQAKEQQ >XP_015829669.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] MKAFAVILALAVLSGCHGRSVLQDDWQTTWEVTMEKFQDYITDLNSKADEVVKDIRSSQISRELDTLVQD SLSELALYKDHLETKLTPYTQEATERVRKDLQLLGDKLNTHVSEAREQMDKYVLELQSMMEQNAEDVKVR VSAYTRKLKKRLHKDTQEIQRHITDYITELQTRASDNVEDMRTQLDPYFSQVRDNAQAKISTLNDLLQSH VEDMKTKIQTAAEDIKGRLESKTGDLGSTLGKKMEEMRNWFEPYVSMIRDGM >XP_019349668.1 PREDICTED: apolipoprotein E [Alligator mississippiensis] MRERLHTDVTVLGERLRVDMEEAKTRVQQYLGEARQVAGQNLEDVRSRVGTYLRKLRKRLAKDTEELRRK LEAYSKEATQHLETVREDLEPLREKGQQRLETLQQALRDQGQRLREQLEVRAQEMRGSLDRAATQLQEWL EPFLEDIRTQMQGLLDKLQAKEQQ >XP_020753894.1 apolipoprotein E [Odocoileus virginianus texanus] MKILWVAVVVALLAGCQADMEGELGPEEPRTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLN TQVIQELTALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQ AMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAA TLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRS WFEPLVEDMQRQWAGLVEKVQLALRPSPTSLPSENH >XP_040183393.1 apolipoprotein E [Rana temporaria] MKVIFLLLTIGLLAGAQARSLFKDEPKAKWESALDSFWQTLNKMEEAADEATSKMKDSQLGKELDGLIKE TMEELSNYAEDLKSKVGPMAQDANQRFTDEISALADKLKNDMEDTKTRAIQYSGDLKSMFDQNIEDVQGK VSMYMKKLKKRLAKDSEDLKSKLNQYGDDLNKNTQEKVEYLRKNVEPIVSNLKKKGQQRLQSLKDAMDEQ GKQLRDRFASVAKDVQGKVKKMASDVKSSVDKLSDQMRKWFNPSVENLRNQLQGLAKSLPPKKA >KAB0346348.1 hypothetical protein FD754_011205 [Muntiacus muntjak] MKVLWVAVVVALLAGCQADMEGELGPEEPLTPEQPRRQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTAL MEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQTTEELRARMASHLRK LRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGV RAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPSPTSPPSENH >XP_043293839.1 apolipoprotein E [Cervus canadensis] MKVLWVAVVVALLAGCQADMEGELGPEEPLTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTAL MEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQTTEELRARMASHLRK LRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAATLSTVAGQPLLERAEAWRQKLHGRLEEVGV RAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPSPTSPPSENH >XP_043774413.1 apolipoprotein E-like [Cervus elaphus] MASHLLKLRKRLLRDTGDLNKRLAFYQARASEGAERSVSAIRERLGPLGEQGQSRAATLSTPAGQPLLERAEAWRQKLHG RLEEVGVRAQDRLDKMRQQLEEVRGKVEEQGSQMRLQAEAFQARLRSWFEPLVEGMQRQWAGLVEKVQLTPRPSSHPEPP VPPAYRRPCSCPSCPLGGP >XP_018083630.1 apolipoprotein E [Xenopus laevis] MKVTLLLLTLGLLAGAQARSLFRDAPKTKWESALDSFWLTVNKMEAAADETRAQMKDSPITKELDGLIKDTMEELSNYAE DLKSKVSPMAQDAQQRFTEEISALSDNLKSDMEDTKNKAIQYSGDLRMMFDQNIEDVQGKVNIYMKKLKKRISKDSEDLK KKLSQYGDDFRKSTEDKVENVRKAIEPYVSNVKDKGQQRLMTMKDAMDEQGKQLRDQFHSVVKDAQAKMKKAASDVKSSV DKLGEQFRKWFNPNVESLRNQLQVMAKNLQPPKANK
Mafft alignment of selected proteins >sp|P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1 ---------------------------------MKVLWAAL-LVTFLAGCQAKVEQA-VE TEPE------PELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELR ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGE VQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERL GPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRA KLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGT-SA--------- ------APVPSDNH >sp|O42364|APOEB_DANRE Apolipoprotein Eb OS=Danio rerio OX=7955 GN=apoeb PE=2 SV=1 ---------------------------------MRSLVVFF-ALAVLTGCQARSLFQADA PQ--------------------PRWEEMVDRFWQYVSELNTQTDGMVQNIKGSQLSRELD TLITDTMAELSSYSENLQTQMTPYASDAAGQLSKDLQLLAGKLQTDMTDAKERSTQYLQE LKTMMEQNADDVKNRVGTYTRKLKKRLNKDTEEIRNTVATYMSEMQSRASQNADAVKDRF QPYMSQAQDGA-----------TQKLGAISELMKAQAQEVS-------EQLEVQAGALKE KLEETAENLRTSLEGRVDELTSLLAPYSQKIREQLQEVMDKIKEATAA-LP--------- ------TQA----- >tr|Q503V2|Q503V2_DANRE Apolipoprotein Ea OS=Danio rerio OX=7955 GN=apoea PE=2 SV=1 ---------------------------------MKFVAVIV-ALAVISGCQGRFLFQ-DE PR--------------------SRWEEAVDQFWNHVSELTTRAEEMRDNIKATQLGRELD TLISDSMMELQMYRDDLHSKLAPYAQERAQKFNEDLQLLVTKLRTHMEEAKDRVTEYTEE LRTMVEQNSDELKNKANSYAKKLRKRFNKDIQEINKKMSTYLEEVQSRASQSVEDVKDRL EPYFTSMHERA-----------QQKLVNLREALRSQAEEIK-------ERLDSRMQELRD QVEKTKENVHNTLQQKAEDVQKWFEPYVSHIQKQMEPVWESL------------------ -------------- >NP_033826.2 apolipoprotein E precursor [Mus musculus] ---------------------------------MKALWAVL-LVTLLTGCLAEGEP---- -----------EVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELT ALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNE VHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERL GPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRS KMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPII-------- ------TPVAQENQ >NP_620183.2 apolipoprotein E precursor [Rattus norvegicus] ---------------------------------MKALWALL-LVPLLTGCLAEGEL---- -----------EVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELT VLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNE VNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERL GPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRS KMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATNSIAS------- ------TTVPLENQ >XP_005219205.2 apolipoprotein E isoform X1 [Bos taurus] MRDSENPLLLPFIEHLLGAHNRPKIGWPIASQKMKVLWVAV-VVALLAGCQADMEGE-LG PEE-------PLTTQQPRGKDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELT ALMEETMKEVKAYKEELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSLSAIRERF GPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKIRQQLEEVHA KVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRP-SP--------- ------TSPPSENH >NP_999473.1 apolipoprotein E precursor [Sus scrofa] ---------------------------------MRVLWVAL-VVTLLAGCRTEDEPG-PP PEV-------HVWWEESKWQGSQPWEQALGRFWDYLRWVQSLSDQVQEELLSTKVTQELT ELIEESMKEVKAYREELEAQLGPVTQETQARLSKELQAAQARVGADMEDVRNRLVLYRSE VHNMLGQTTEELRSRLASHLRNVRKRLVRDTEDLQKRLAVYQAGLREGAERSVSALRERL GPLVEQGRLRAATLSTRAGQPLRERAEAWGQKLRGRLEEMGSRTRDRLDEMRDELEEVRT KVEEQGSQLRLQAEAFQARLKGWFEPLVEDMRRQWAGLVERMQSAVSISSS--------- ------TSAPSDNQ >NP_001009007.1 apolipoprotein E precursor [Pan troglodytes] ---------------------------------MKVLWAAL-LVTFLAGCQAKVEQV-VE TEPE------PELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELT ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGE VQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERL GPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRA KLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGT-SA--------- ------APVPSDNH >XP_533644.1 apolipoprotein E [Canis lupus familiaris] ---------------------------------MKVLWAAL-VVTLLAGCWADVQPE-PE LERELEPKVQQELEPEAGWQTGQPWEAALARFWDYLRWVQTLSDQVQEGVLNTQVTQELT ALMDETMKEVKAYKAELDEQLGPMTSETQARVAKELQAAQARLRSDMEDVRNRLTQYRGE LQAMLGQSSEELRARFASHMRKLRKRVLRDAEDLQRRLAVYKAGVREGAERSVSSIRERL WPLLEQARERNAKVGALATQPLLERADALGQQLRGQLEEMSSRARGHLEEMREQIQEVRV KMEEQADQIRQKAEAFQARLKSWFEPLLEDMQRQWDGLVEKVQAAVAT-IP--------- ------TSKPVEEP >NP_001076112.1 apolipoprotein E precursor [Oryctolagus cuniculus] ---------------------------------MKVWWAVL-AAAILAGCRAQTEQE-V- -----------EVPEQARWKAGQPWELALGRFWDYLRWVQSLSDQVQEELLSSQVTQELT MLMEETMKEVKAYKSELEEQLSPMAQEHRARLSKELQVAGA-LEADMEDVCNRLAQYRGE AQAMLGQSTEELARAFSSHLRKLRKRLLRDAEDLQKRMAVYGAGAREGAERGVSAVRERL GSRLERGRLRVATVGTLAGRPLRERAQAWGERLRGHLEEVGSRARDRLNEVREQVEEVRV KVEEQAPQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKLQAAMPSKAP--------- ------AAAPIENQ >XP_002829425.2 apolipoprotein E [Pongo abelii] ---------------------------------MKVLWAAL-LVTFLAGCQANVEQV-VE PEPE------PELRQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLNSQVTQELT ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGE VQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERL GPLVEQGRVRAATVGSVAGKPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRA KLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGT-SA--------- ------APVPSDNH >XP_008969013.3 LOW QUALITY PROTEIN: apolipoprotein E [Pan paniscus] MSSGASRKC----SWDLGKPWPPD--WPITGRKMKVLWAAL-LVTFLAGCQAKVEQV-VE TEPE------PELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELT ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGE VQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERL GPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRA KLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGT-SA--------- ------APVPSDNH >XP_023101561.1 apolipoprotein E [Felis catus] ---------------------------------MKVLWAAL-LVALLAGCWADVEPE-PQ LER--------ELEPEAPWQASQPWEQALGRFRDYLRWVQTLSDQVQEEVLNTQVTQELT VLMEETMKEVKAYREELEEQLGPMASETQARVAKELQAAQARLGSDMEDVRNRLAQYRSE VQAMLGQSAEELRGRLASHLRKLRKRLLRDAEDLHKRLAVYRAGVREGAERSVSSIRERF WPLVEQARARNANVAAVAAQPLRERAEALGQQLRGR-----------LDEVREQVAEMRV KMEEQADQMRQQAEAFQARLKSWFEPLVQDMQRQWAGLVEKLQAAVGT-SP--------- ------TTAPVEKQ >XP_027834259.1 apolipoprotein E [Ovis aries] ---------------------------------MKVLWVAL-VVALLAGCQADMEGE-LG SEE-------PLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLNTQVIQELT VLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERL RPLVEQSQSRAATLSTQVGQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRS KVEEQGSQIRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALHL-SP--------- ------TSPPSENH >XP_030863288.1 LOW QUALITY PROTEIN: apolipoprotein E [Gorilla gorilla gorilla] MSSGASRKM----SWDLGKPWPPD--WPITGRKMKVLWAAL-LVTFLAGCQAKVEQA-VE TEPE------PELHQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELT ALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLAQYRGE VQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERL GPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRA KLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGT-SA--------- ------APVPSDNH >XP_023815792.1 apolipoprotein Eb [Oryzias latipes] ---------------------------------MRVFAVIL-ALAVLSGCHSRTVPL-ED LK--------------------NTWEVTVEKFQDYITDLNTKADGVLENIRSSQISRELE TLIQDSMSELSMYKDDLETKLHPFTQQRAERLRQDLQLMADKLREHMKEAREQVDRYVQE LQTMMEQNADDVKLRVSTYSRKLKKRLTKDTQEIKRYVSEYFEELHSRTSENVEELKARL DPYFSQVRDNA-----------QAKISTLNELLQSQIENVK-------TRMQTTHEDVKE RVKVAAEELRSGVETRMQELRNWFQPYVSMVRESL------------------------- -------------- >XP_017918050.1 PREDICTED: apolipoprotein E [Capra hircus] ---------------------------------MKVLWVAL-VVALLAGCQADMEGE-LG SEE-------PLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLNTQVIQELT VLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERL RPLVEQGQSRAATLSTQAAQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRA KVEEQGSQIRLQAEAFQARLRSWFEPLVGDMQRQWAGLVEKVQLALHL-SP--------- ------TSPPSENH >XP_006038593.1 apolipoprotein E isoform X1 [Alligator sinensis] ---------------------------------MRVWTVLLGAVLLLAACQA------EE TK--------------------AKWEETVEVFREYVNRLSLATDDITEQITSSQMGKEMD MLIKDMVAELQAYRKDVEERLGPHAVVMRERLHTDVTVLGERLRVDMEEAKTRVQQYLGE ARQVAGQNLEDVRSRVGTYLRKLRKRLAKDTEELRRKLEAYSAE----ATRHLETVREDL EPL----REKG-----------QQRLAALQQALRDQGQRLR-------EQLEVR------ -----AQDMRGSLDRAATQLQEWLEPFLADIRTQMQGLLDKLQAKEQQ------------ -------------- >XP_015829669.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] ---------------------------------MKAFAVIL-ALAVLSGCHGRSVLQ-DD WQ--------------------TTWEVTMEKFQDYITDLNSKADEVVKDIRSSQISRELD TLVQDSLSELALYKDHLETKLTPYTQEATERVRKDLQLLGDKLNTHVSEAREQMDKYVLE LQSMMEQNAEDVKVRVSAYTRKLKKRLHKDTQEIQRHITDYITELQTRASDNVEDMRTQL DPYFSQVRDNA-----------QAKISTLNDLLQSHVEDMK-------TKIQTAAEDIKG RLESKTGDLGSTLGKKMEEMRNWFEPYVSMIRDGM------------------------- -------------- >XP_019349668.1 PREDICTED: apolipoprotein E [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MRERLHTDVTVLGERLRVDMEEAKTRVQQYLGE ARQVAGQNLEDVRSRVGTYLRKLRKRLAKDTEELRRKLEAYSKE----ATQHLETVREDL EPL----REKG-----------QQRLETLQQALRDQGQRLR-------EQLEVR------ -----AQEMRGSLDRAATQLQEWLEPFLEDIRTQMQGLLDKLQAKEQQ------------ -------------- >XP_020753894.1 apolipoprotein E [Odocoileus virginianus texanus] ---------------------------------MKILWVAV-VVALLAGCQADMEGE-LG PEE-------PRTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELT ALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERL GPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRA KVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRP-SP--------- ------TSLPSENH >XP_040183393.1 apolipoprotein E [Rana temporaria] ---------------------------------MKVIFLLL-TIGLLAGAQARSLFK-DE PK--------------------AKWESALDSFWQTLNKMEEAADEATSKMKDSQLGKELD GLIKETMEELSNYAEDLKSKVGPMAQDANQRFTDEISALADKLKNDMEDTKTRAIQYSGD LKSMFDQNIEDVQGKVSMYMKKLKKRLAKDSEDLKSKLNQYGDDLNKNTQEKVEYLRKNV EPIVSNLKKKG-----------QQRLQSLKDAMDEQGKQLR-------DRFASVAKDVQG KVKKMASDVKSSVDKLSDQMRKWFNPSVENLRNQLQGLAKSLPPKKA------------- -------------- >KAB0346348.1 hypothetical protein FD754_011205 [Muntiacus muntjak] ---------------------------------MKVLWVAV-VVALLAGCQADMEGE-LG PEE-------PLTPEQPRRQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELT ALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERL GPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRA KVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRP-SP--------- ------TSPPSENH >XP_043293839.1 apolipoprotein E [Cervus canadensis] ---------------------------------MKVLWVAV-VVALLAGCQADMEGE-LG PEE-------PLTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELT ALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSE VQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERL GPLVEQGQSRAATLSTVAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRA KVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRP-SP--------- ------TSPPSENH >XP_043774413.1 apolipoprotein E-like [Cervus elaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------MASHLLKLRKRLLRDTGDLNKRLAFYQARASEGAERSVSAIRERL GPLGEQGQSRAATLSTPAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRG KVEEQGSQMRLQAEAFQARLRSWFEPLVEGMQRQWAGLVEKVQLTPRPSSHPEPPVPPAY RRPCSCPSCPLGGP >XP_018083630.1 apolipoprotein E [Xenopus laevis] ---------------------------------MKVTLLLL-TLGLLAGAQARSLFR-DA PK--------------------TKWESALDSFWLTVNKMEAAADETRAQMKDSPITKELD GLIKDTMEELSNYAEDLKSKVSPMAQDAQQRFTEEISALSDNLKSDMEDTKNKAIQYSGD LRMMFDQNIEDVQGKVNIYMKKLKKRISKDSEDLKKKLSQYGDDFRKSTEDKVENVRKAI EPYVSNVKDKG-----------QQRLMTMKDAMDEQGKQLR-------DQFHSVVKDAQA KMKKAASDVKSSVDKLGEQFRKWFNPNVESLRNQLQVMAKNLQPPKANK----------- --------------
BMGE Cleaned alignment of selected proteins >sp|P02649|APOE_HUMAN Apolipoprotein E OS=Homo sapiens OX=9606 GN=APOE PE=1 SV=1 MKVLWAALLVTFLAGCQAKVEQVETEPPELRQQTEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTAPVPSDNH >sp|O42364|APOEB_DANRE Apolipoprotein Eb OS=Danio rerio OX=7955 GN=apoeb PE=2 SV=1 MRSLVVFFALAVLTGCQARSLFDAPQ-------------PRWEEMVDRFWQYVSELNTQTDGMVQNIKGSQLSRELDTLITDTMAELSSYSENLQTQMTPYASDAAGQLSKDLQLLAGKLQTDMTDAKERSTQYLQELKTMMEQNADDVKNRVGTYTRKLKKRLNKDTEEIRNTVATYMSEMQSRASQNADAVKDRFQPYMSQAQDGA-----------TQKLGAISELMKAQAQEVS-------EQLEVQAGALKEKLEETAENLRTSLEGRVDELTSLLAPYSQKIREQLQEVMDKIKEATAATQA----- >tr|Q503V2|Q503V2_DANRE Apolipoprotein Ea OS=Danio rerio OX=7955 GN=apoea PE=2 SV=1 MKFVAVIVALAVISGCQGRFLFDEPR-------------SRWEEAVDQFWNHVSELTTRAEEMRDNIKATQLGRELDTLISDSMMELQMYRDDLHSKLAPYAQERAQKFNEDLQLLVTKLRTHMEEAKDRVTEYTEELRTMVEQNSDELKNKANSYAKKLRKRFNKDIQEINKKMSTYLEEVQSRASQSVEDVKDRLEPYFTSMHERA-----------QQKLVNLREALRSQAEEIK-------ERLDSRMQELRDQVEKTKENVHNTLQQKAEDVQKWFEPYVSHIQKQMEPVWESL-------------- >NP_033826.2 apolipoprotein E precursor [Mus musculus] MKALWAVLLVTLLTGCLAEGEP------EVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATTPVAQENQ >NP_620183.2 apolipoprotein E precursor [Rattus norvegicus] MKALWALLLVPLLTGCLAEGEL------EVTDQLPGQSDQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTVLMEDTMTEVKAYKKELEEQLGPVAEETRARLAKEVQAAQARLGADMEDLRNRLGQYRNEVNTMLGQSTEELRSRLSTHLRKMRKRLMRDADDLQKRLAVYKAGAQEGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQALSDRIRGRLEEVGNQARDRLEEVREQMEEVRSKMEEQTQQIRLQAEIFQARIKGWFEPLVEDMQRQWANLMEKIQASVATTTVPLENQ >XP_005219205.2 apolipoprotein E isoform X1 [Bos taurus] MKVLWVAVVVALLAGCQADMEGLGPEEPLTTQQPRGKDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTALMEETMKEVKAYKEELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSLSAIRERFGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKIRQQLEEVHAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPTSPPSENH >NP_999473.1 apolipoprotein E precursor [Sus scrofa] MRVLWVALVVTLLAGCRTEDEPPPPEVHVWWEESKWQGSQPWEQALGRFWDYLRWVQSLSDQVQEELLSTKVTQELTELIEESMKEVKAYREELEAQLGPVTQETQARLSKELQAAQARVGADMEDVRNRLVLYRSEVHNMLGQTTEELRSRLASHLRNVRKRLVRDTEDLQKRLAVYQAGLREGAERSVSALRERLGPLVEQGRLRAATLSTRAGQPLRERAEAWGQKLRGRLEEMGSRTRDRLDEMRDELEEVRTKVEEQGSQLRLQAEAFQARLKGWFEPLVEDMRRQWAGLVERMQSAVSITSAPSDNQ >NP_001009007.1 apolipoprotein E precursor [Pan troglodytes] MKVLWAALLVTFLAGCQAKVEQVETEPPELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTAPVPSDNH >XP_533644.1 apolipoprotein E [Canis lupus familiaris] MKVLWAALVVTLLAGCWADVQPPELERQELEPEAGWQTGQPWEAALARFWDYLRWVQTLSDQVQEGVLNTQVTQELTALMDETMKEVKAYKAELDEQLGPMTSETQARVAKELQAAQARLRSDMEDVRNRLTQYRGELQAMLGQSSEELRARFASHMRKLRKRVLRDAEDLQRRLAVYKAGVREGAERSVSSIRERLWPLLEQARERNAKVGALATQPLLERADALGQQLRGQLEEMSSRARGHLEEMREQIQEVRVKMEEQADQIRQKAEAFQARLKSWFEPLLEDMQRQWDGLVEKVQAAVATTSKPVEEP >NP_001076112.1 apolipoprotein E precursor [Oryctolagus cuniculus] MKVWWAVLAAAILAGCRAQTEQV-----EVPEQARWKAGQPWELALGRFWDYLRWVQSLSDQVQEELLSSQVTQELTMLMEETMKEVKAYKSELEEQLSPMAQEHRARLSKELQVAGA-LEADMEDVCNRLAQYRGEAQAMLGQSTEELARAFSSHLRKLRKRLLRDAEDLQKRMAVYGAGAREGAERGVSAVRERLGSRLERGRLRVATVGTLAGRPLRERAQAWGERLRGHLEEVGSRARDRLNEVREQVEEVRVKVEEQAPQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKLQAAMPSAAAPIENQ >XP_002829425.2 apolipoprotein E [Pongo abelii] MKVLWAALLVTFLAGCQANVEQVEPEPPELRQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLNSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSVAGKPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAVGTAPVPSDNH >XP_008969013.3 LOW QUALITY PROTEIN: apolipoprotein E [Pan paniscus] MKVLWAALLVTFLAGCQAKVEQVETEPPELHQQAEWQSGQRWELALGHFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLVQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTAPVPSDNH >XP_023101561.1 apolipoprotein E [Felis catus] MKVLWAALLVALLAGCWADVEPPQLER-ELEPEAPWQASQPWEQALGRFRDYLRWVQTLSDQVQEEVLNTQVTQELTVLMEETMKEVKAYREELEEQLGPMASETQARVAKELQAAQARLGSDMEDVRNRLAQYRSEVQAMLGQSAEELRGRLASHLRKLRKRLLRDAEDLHKRLAVYRAGVREGAERSVSSIRERFWPLVEQARARNANVAAVAAQPLRERAEALGQQLRGR-----------LDEVREQVAEMRVKMEEQADQMRQQAEAFQARLKSWFEPLVQDMQRQWAGLVEKLQAAVGTTTAPVEKQ >XP_027834259.1 apolipoprotein E [Ovis aries] MKVLWVALVVALLAGCQADMEGLGSEEPLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLNTQVIQELTVLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLRPLVEQSQSRAATLSTQVGQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRSKVEEQGSQIRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALHLTSPPSENH >XP_030863288.1 LOW QUALITY PROTEIN: apolipoprotein E [Gorilla gorilla gorilla] MKVLWAALLVTFLAGCQAKVEQVETEPPELHQQAEWQSGQRWELALGRFWDYLRWVQTLSEQVQEELLSSQVTQELTALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQARLGADMEDVRGRLAQYRGEVQAMLGQSTEELRARLASHLRKLRKRLLRDADDLQKRLAVYQAGAREGAERGVSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQAAMGTAPVPSDNH >XP_023815792.1 apolipoprotein Eb [Oryzias latipes] MRVFAVILALAVLSGCHSRTVPEDLK-------------NTWEVTVEKFQDYITDLNTKADGVLENIRSSQISRELETLIQDSMSELSMYKDDLETKLHPFTQQRAERLRQDLQLMADKLREHMKEAREQVDRYVQELQTMMEQNADDVKLRVSTYSRKLKKRLTKDTQEIKRYVSEYFEELHSRTSENVEELKARLDPYFSQVRDNA-----------QAKISTLNELLQSQIENVK-------TRMQTTHEDVKERVKVAAEELRSGVETRMQELRNWFQPYVSMVRESL--------------------- >XP_017918050.1 PREDICTED: apolipoprotein E [Capra hircus] MKVLWVALVVALLAGCQADMEGLGSEEPLPPEQPRGQDSQPWEQVLGRLWDYLRWVQTLSDQVQEELLNTQVIQELTVLMEETMKEVKAYREELEGQLAPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQSTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLRPLVEQGQSRAATLSTQAAQPLLDRAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGSQIRLQAEAFQARLRSWFEPLVGDMQRQWAGLVEKVQLALHLTSPPSENH >XP_006038593.1 apolipoprotein E isoform X1 [Alligator sinensis] MRVWTVLLAVLLLAACQA----EETK-------------AKWEETVEVFREYVNRLSLATDDITEQITSSQMGKEMDMLIKDMVAELQAYRKDVEERLGPHAVVMRERLHTDVTVLGERLRVDMEEAKTRVQQYLGEARQVAGQNLEDVRSRVGTYLRKLRKRLAKDTEELRRKLEAYSAE----ATRHLETVREDLEPL----REKG-----------QQRLAALQQALRDQGQRLR-------EQLEVR-----------AQDMRGSLDRAATQLQEWLEPFLADIRTQMQGLLDKLQAKEQQ-------- >XP_015829669.1 PREDICTED: apolipoprotein Eb-like [Nothobranchius furzeri] MKAFAVILALAVLSGCHGRSVLDDWQ-------------TTWEVTMEKFQDYITDLNSKADEVVKDIRSSQISRELDTLVQDSLSELALYKDHLETKLTPYTQEATERVRKDLQLLGDKLNTHVSEAREQMDKYVLELQSMMEQNAEDVKVRVSAYTRKLKKRLHKDTQEIQRHITDYITELQTRASDNVEDMRTQLDPYFSQVRDNA-----------QAKISTLNDLLQSHVEDMK-------TKIQTAAEDIKGRLESKTGDLGSTLGKKMEEMRNWFEPYVSMIRDGM--------------------- >XP_019349668.1 PREDICTED: apolipoprotein E [Alligator mississippiensis] --------------------------------------------------------------------------------------------------------MRERLHTDVTVLGERLRVDMEEAKTRVQQYLGEARQVAGQNLEDVRSRVGTYLRKLRKRLAKDTEELRRKLEAYSKE----ATQHLETVREDLEPL----REKG-----------QQRLETLQQALRDQGQRLR-------EQLEVR-----------AQEMRGSLDRAATQLQEWLEPFLEDIRTQMQGLLDKLQAKEQQ-------- >XP_020753894.1 apolipoprotein E [Odocoileus virginianus texanus] MKILWVAVVVALLAGCQADMEGLGPEEPRTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPTSLPSENH >XP_040183393.1 apolipoprotein E [Rana temporaria] MKVIFLLLTIGLLAGAQARSLFDEPK-------------AKWESALDSFWQTLNKMEEAADEATSKMKDSQLGKELDGLIKETMEELSNYAEDLKSKVGPMAQDANQRFTDEISALADKLKNDMEDTKTRAIQYSGDLKSMFDQNIEDVQGKVSMYMKKLKKRLAKDSEDLKSKLNQYGDDLNKNTQEKVEYLRKNVEPIVSNLKKKG-----------QQRLQSLKDAMDEQGKQLR-------DRFASVAKDVQGKVKKMASDVKSSVDKLSDQMRKWFNPSVENLRNQLQGLAKSLPPKKA--------- >KAB0346348.1 hypothetical protein FD754_011205 [Muntiacus muntjak] MKVLWVAVVVALLAGCQADMEGLGPEEPLTPEQPRRQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAATLSTLAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPTSPPSENH >XP_043293839.1 apolipoprotein E [Cervus canadensis] MKVLWVAVVVALLAGCQADMEGLGPEEPLTPEQPRGQDSQPWEQALGRFWDYLRWVQTLSDQVQEELLNTQVIQELTALMEETMKEVKAYREELEGQLGPMAQETQARVSKELQAAQARLGSDMEDLRNRLAQYRSEVQAMLGQTTEELRARMASHLRKLRKRLLRDADDLKKRLAVYQAGASEGAERSVSAIRERLGPLVEQGQSRAATLSTVAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRAKVEEQGNQMRLQAEAFQARLRSWFEPLVEDMQRQWAGLVEKVQLALRPTSPPSENH >XP_043774413.1 apolipoprotein E-like [Cervus elaphus] --------------------------------------------------------------------------------------------------------------------------------------------------------MASHLLKLRKRLLRDTGDLNKRLAFYQARASEGAERSVSAIRERLGPLGEQGQSRAATLSTPAGQPLLERAEAWRQKLHGRLEEVGVRAQDRLDKMRQQLEEVRGKVEEQGSQMRLQAEAFQARLRSWFEPLVEGMQRQWAGLVEKVQLTPRPPSCPLGGP >XP_018083630.1 apolipoprotein E [Xenopus laevis] MKVTLLLLTLGLLAGAQARSLFDAPK-------------TKWESALDSFWLTVNKMEAAADETRAQMKDSPITKELDGLIKDTMEELSNYAEDLKSKVSPMAQDAQQRFTEEISALSDNLKSDMEDTKNKAIQYSGDLRMMFDQNIEDVQGKVNIYMKKLKKRISKDSEDLKKKLSQYGDDFRKSTEDKVENVRKAIEPYVSNVKDKG-----------QQRLMTMKDAMDEQGKQLR-------DQFHSVVKDAQAKMKKAASDVKSSVDKLGEQFRKWFNPNVESLRNQLQVMAKNLQPPKAN--------
PhyML tree of selected proteins (XP_040183393_1_apolipoprotein_E__Rana_temporaria_:0.12257677,XP_018083630_1_apolipoprotein_E__Xenopus_laevis_:0.17731361,((((NP_033826_2_apolipoprotein_E_precursor__Mus_musculus_:0.02177161,NP_620183_2_apolipoprotein_E_precursor__Rattus_norvegicus_:0.0556038):0.16393168,(((XP_023101561_1_apolipoprotein_E__Felis_catus_:0.06970216,XP_533644_1_apolipoprotein_E__Canis_lupus_familiaris_:0.15161374):0.12317075,(NP_999473_1_apolipoprotein_E_precursor__Sus_scrofa_:0.19631772,((XP_005219205_2_apolipoprotein_E_isoform_X1__Bos_taurus_:0.02695266,(KAB0346348_1_hypothetical_protein_FD754_011205__Muntiacus_muntjak_:0.003308,(XP_043293839_1_apolipoprotein_E__Cervus_canadensis_:0.00331516,(XP_043774413_1_apolipoprotein_E_like__Cervus_elaphus_:0.13629185,XP_020753894_1_apolipoprotein_E__Odocoileus_virginianus_texanus_:0.00000001):0.00995602):0.00000001):0.00320254):0.00580902,(XP_017918050_1_PREDICTED__apolipoprotein_E__Capra_hircus_:0.00660926,XP_027834259_1_apolipoprotein_E__Ovis_aries_:0.00976089):0.04205594):0.14590281):0.04458983):0.04995382,(NP_001076112_1_apolipoprotein_E_precursor__Oryctolagus_cuniculus_:0.18314291,(XP_030863288_1_LOW_QUALITY_PROTEIN__apolipoprotein_E__Gorilla_gorilla_gorilla_:0.00000001,((NP_001009007_1_apolipoprotein_E_precursor__Pan_troglodytes_:0.00000001,XP_008969013_3_LOW_QUALITY_PROTEIN__apolipoprotein_E__Pan_paniscus_:0.00000001):0.00327219,(sp_P02649_APOE_HUMAN_Apolipoprotein_E_OS_Homo_sapiens_OX_9606_GN_APOE_PE_1_SV_1:0.01666726,XP_002829425_2_apolipoprotein_E__Pongo_abelii_:0.01671195):0.00658063):0.00327):0.10379364):0.03504896):0.06487829):1.08102311,(XP_019349668_1_PREDICTED__apolipoprotein_E__Alligator_mississippiensis_:0.005716,XP_006038593_1_apolipoprotein_E_isoform_X1__Alligator_sinensis_:0.0353847):0.50778494):0.03530909,(sp_O42364_APOEB_DANRE_Apolipoprotein_Eb_OS_Danio_rerio_OX_7955_GN_apoeb_PE_2_SV_1:0.44581314,(tr_Q503V2_Q503V2_DANRE_Apolipoprotein_Ea_OS_Danio_rerio_OX_7955_GN_apoea_PE_2_SV_1:0.48213786,(XP_015829669_1_PREDICTED__apolipoprotein_Eb_like__Nothobranchius_furzeri_:0.27057613,XP_023815792_1_apolipoprotein_Eb__Oryzias_latipes_:0.19062986):0.36166663):0.06195364):0.39418415):0.67747318);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)