PB0171

DATABASE

Click here to access PB0171 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0171	P83110	Serine protease HTRA3	HTRA3	Prsp, Tasp, HtrA serine peptidase 3	Homo_sapiens	May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (PubMed:21321049, PubMed:22229724).

Domains

Gene Ontology

PF00219 (IGFBP) PF07648 (Kazal_2) PF17820 (PDZ_6)

GO:0004175 (enables) endopeptidase activity GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0042802 (enables) identical protein binding GO:0006508 (involved in) proteolysis GO:0030512 (involved in) negative regulation of transforming growth factor beta receptor signaling pathway GO:0030514 (involved in) negative regulation of BMP signaling pathway GO:0005576 (located in) extracellular region

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P83110|HTRA3_HUMAN Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 PE=1 SV=2 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >sp|P83110-2|HTRA3_HUMAN Isoform 2 of Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH >tr|F1REI0|F1REI0_DANRE HtrA serine peptidase 3b OS=Danio rerio OX=7955 GN=htra3b PE=3 SV=3 MQVILCVSVVFLYYKAAVADKLKCPERCDVSKCPSPSCPSGYVPDRCDCCLVCAQGEGEP CGRKDDLPCGDGLECVCQCRYSSKVCGSDGNTYGNICQLKAVSRKALQQGKLIQLAPLSC PLGISPSHPLFGRTVPLSSGSGFVMSETGLIVTNAHVVSSTTSVSGHQRLKVQMRDGDVY EATIQDIDKKSDIATIKINPQKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVS TAQRDGKELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSD RITRFLNDSLGKSVKKRFIGIRMLTITDALVEELKQQNPDFPDVSSGIFVHEVVPHSPAQ KGGIRDGDIIVKLNGEPLLSTSDLKEALNQDMTLLLEVRRGNDDLLFNIEPDIIMQ
Selected proteins from model organisms >sp|P83110|HTRA3_HUMAN Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 PE=1 SV=2 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKDWKKRFIGIR MRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >sp|P83110-2|HTRA3_HUMAN Isoform 2 of Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGE PCGGPLDSPCGESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQ LQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIM SEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLP VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAII NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIKAPSLAVH >tr|F1REI0|F1REI0_DANRE HtrA serine peptidase 3b OS=Danio rerio OX=7955 GN=htra3b PE=3 SV=3 MQVILCVSVVFLYYKAAVADKLKCPERCDVSKCPSPSCPSGYVPDRCDCCLVCAQGEGEP CGRKDDLPCGDGLECVCQCRYSSKVCGSDGNTYGNICQLKAVSRKALQQGKLIQLAPLSC PLGISPSHPLFGRTVPLSSGSGFVMSETGLIVTNAHVVSSTTSVSGHQRLKVQMRDGDVY EATIQDIDKKSDIATIKINPQKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVS TAQRDGKELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSD RITRFLNDSLGKSVKKRFIGIRMLTITDALVEELKQQNPDFPDVSSGIFVHEVVPHSPAQ KGGIRDGDIIVKLNGEPLLSTSDLKEALNQDMTLLLEVRRGNDDLLFNIEPDIIMQ >NP_084403.2 serine protease HTRA3 isoform a precursor [Mus musculus] MQARALLPATLAILATLAVLALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGR PLDSPCGDSLECVRGVCRCRWTHTVCGTDGHTYADVCALQAASRRALQVSGTPVRQLQKGACPSGLHQLT SPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQ LKVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIV STAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEF QNKHVKDWKKRFIGIRMRTITPSLVEELKAANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGR PLADSSELQEAVLNESSLLLEVRRGNDDLLFSIIPEVVM >NP_001257956.1 serine protease HTRA3 precursor [Rattus norvegicus] MQARALLPATLATLATLAVSVLAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGR PLDSPCGDSLECVRGVCRCRWTHTVCGTDGHTYADVCALQAASRRALQISGTPVRQLQKGACPSGLHQLT SPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSNTASGRQQ LKVQLQNGDAYEATIQDIDKKSDIATILIHPNKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIV STAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEF QDKHVKDWKKRFIGIRMRTITPSLVEELKTANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGR PLVDSSELQEAVLNESSLLLEVRRGNDDLLFSIMPEVVM >XP_015141331.1 serine protease HTRA3 [Gallus gallus] MRLSLLSPLLLLCLSRSRGSAELPAARAKCPTRCDVSKCPSPSCPSGYVPDRCNCCLICAAGEGDSCGRK EDPPCGDSLDCRYPMGKRFAKGVCQCKLSVQVCGSDGRTYDNICQLKAVSRKALQHGLPAVAQVQKGACE SGHLQSSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSTN AISGRQQLKVQLQNGDTYEATIRDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQN TVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRI TQFLTESLDKQNKDSKKRFIGIRMLTITPALVEELKHNNADFPDVRSGIYVHEVVPNSPSHRGGIQDGDI IVKVNGRPLMTSSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEIVM >XP_016806801.1 serine protease HTRA3 isoform X1 [Pan troglodytes] MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPC GESLECVRGLCRCRGSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRE GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIK DWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_024849478.1 serine protease HTRA3 [Bos taurus] MQARALLLAALAALALAREPPAASCPVRCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPC GESLECVRGLCRCRWANAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQ NGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRD GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTGK DWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >NP_001182272.1 serine protease HTRA3 precursor [Sus scrofa] MQARALLLAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAAVEGEPCGRPVDSPC GESLECARGVCRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFVMSESGLIVTNAHVVSSTNAVTGRQQLKVQLQ NGDTYEATIKDIDKKSDIATIRIRPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRD GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRIARFLTEFQDKQGK DWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIVVKVNGRPLADSS ELQEAALTESPLLLEVRRGNDDLLFSIAPEVVP >XP_024102294.1 serine protease HTRA3 isoform X1 [Pongo abelii] MQARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPC GESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRE GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQTK DWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_022271988.2 serine protease HTRA3 isoform X7 [Canis lupus familiaris] MPARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAAGEGEPCGRPLDSPC GESLECARGVCRCRWAHAVCGTDGHTYANVCALQAASRRALELSGTPVRQLQKGACPSGLHQLTSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNAVSGRQQLKVQLQ NGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRD GKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLTEFQDKHVK DWKKRFIGIRMRTITPSLVEELKASNPDFPSVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSS ELQEAVLTESPLLLEVRRGNDDILFSISPEVVL >XP_003816537.4 serine protease HTRA3 isoform X1 [Pan paniscus] MQARALFLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPC GESLECVRGLCRCRGSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRE GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIK DWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_023109203.1 serine protease HTRA3 isoform X1 [Felis catus] MEVGSQAGVTSAGPPSWTWGKGWGGRAGEEGQGDPGLSISTGRGILGTDRDAAGTGTLGAPERGLCPGGS SRPRPRLSGPPANPSPAFPRPGRPAGSRPRKARPGGCRRGPGRGWPRGRAVPSSEGGPRAPLSAAGPRAR SVGPEGAGASPVPAPACPSGPAARPPEPPAHVAARPSPSPPQAAAARPQHRLGAPAGPRPVPRAAAAGRR PGRDAGARAAPGRAGRAGAGPGAPGRVVPRALRRVPVPESPLSGRLRARPVQLLPGVRRQRGRAVRPPPR LAVRGEPGVRARRVPLPLGARRVRHRRAHLRQRVRAAGGQPARAAALRDARAPAAEGRLPVGSPPADQPE VQVQLHRRRGGEDRAGRGPHRALPETPPVWPQRAPVQRLGLHHVGGRPDCHQRPRGVHLQCRLGPATAQG AAAEWRHVRGHHQRHRQEVGHRHHPDPPQEEAPGPAAGPLGRPAARRVCGGHRQSVCPAEHGDHGHRQHG PAGRQGAGPPGLRHGLRPDRRHHQLRELRGPPGEPGRRGHRHQHAQGCGRHLLRHPLGPHHTLPHGVPGQ ARQRDVQPPLPASGQPGASTRCGPCPGTGDSPVRACQAPSYSWWPRLFSKVGSCLLISGAFLAASTLLPF ILAQPPHQRFAESRGPLRASPVPNGPTSRALGTRCSRDRCREGWSPEELLSSENTVWFIGGPCVKTAWSQ GRAGLP >XP_027827066.2 serine protease HTRA3 [Ovis aries] MQARALLLAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRAVDSPC GESLECVRGLCRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLRVQLQ DGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRD GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTGK DWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSS ELQEAVLTESALLLEVRRGNDDLLFSIAPEVVL >XP_004038466.1 serine protease HTRA3 isoform X1 [Gorilla gorilla gorilla] MPARALLLAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPC GESLECVRGLCRCRWSHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQ NGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRE GRELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQIK DWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSS ELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_020557610.1 serine protease HTRA3 [Oryzias latipes] MRVVLWFSSVLLYLGGFANAEPKAKCPTRCDVSSCPSPSCPSGYVPDRCNCCLVCAGAEGEPCGRKDDLP CGDGLECKHPAGKRLSKGFCQCKLGHRVCGSDGKTYRNVCQLKATSRAALQQGQPGVSQTHKGPCESSAG PSRTSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLLGRNIALSSGSGFVMTENGLIVTNAHVVSSSSPV SGQQHLKVQMHNGDVYEATIKDIDKKSDIATIKINPQIKLPVLFLGQSADLRPGEFVVAIGSPFALQNTV TTGIVSSAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITR FLNDSLNKHSKELRPIKKRFIGIRMLTITPALIEELKQQNSDFPNVTSGIYVHEVVPHSPAQKGGIKDGD IIVKLNGKPLTSTSDLQAALQEETALLLEIRRDNDDLLFNIEPDVIMQ >XP_021143900.1 serine protease HTRA3 isoform X1 [Columba livia] MRVSLLSPLLLLSLSYSPGAAELLAARAKCPTRCDVSKCPSPSCPSGYVPDRCNCCLICAAGEGDSCGRK EDPPCGDSLDCRYPMGKRFAKGVCQCKLSAQVCGSDGRTYDNICQLKAVSRKALQHGLPAVAQVQKGACE SGHLQSSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSTN AVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQN TVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRI TQFLTESHDKQSKDGKKRFIGIRMLTITPALVEELKHNNADFPDVRSGIYVHEVVPNSPSHRGGIQDGDI IVKVNGRPLMTSSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_017905282.1 PREDICTED: serine protease HTRA3 [Capra hircus] MQARALLLAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRAVHSPC GESLECVRGLCRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKF NFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQ NGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRD GRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTSK DWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSS ELQEAVLTESALLLEVRRGNDDLLFSIAPEVVL >XP_006017074.1 serine protease HTRA3 isoform X1 [Alligator sinensis] MRGSWLSPLFMLVLTFSPVFAEPSGARGKCPARCDVSKCPSPSCPSGYVPDHCNCCLICAAGEGDSCGRK EDPPCGDSLDCRYPMGKRFAKGVCQCKLSYQVCGSDRRTYDNVCQLKAVSRKALQQGLPAVIQIQKGACE SGHLQPSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSSN AISGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQN TVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRI TRFLTESHDKQNKDGKKRFIGIRMLTITPALVEELKHSNADFPDVRSGIYVHEVVPNSPSHRGGIKDGDI IVKVNGRPLITTSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_006270391.1 PREDICTED: serine protease HTRA3 isoform X1 [Alligator mississippiensis] MRGSWLSPLFLLVLTFSPVFAEPSGARGKCPARCDVSKCPSPSCPSGYVPDHCNCCLICAAGEGDSCGRK EDPPCGDSLDCRYPMGKRFAKGVCQCKLSYQVCGSDGRTYDNVCQLKAVSRKALQQGLPAVIQIQKGACE SGHLQPSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSSN AISGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQN TVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRI TRFLTESHDKQNKDGKKRFIGIRMLTITPALVEELKHSNADFPDVRSGIYVHEVVPNSPSHRGGIKDGDI IVKVNGRPLITTSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_020770625.1 serine protease HTRA3 [Odocoileus virginianus texanus] MQAWEGVPQGARTPWPSSGPPPEGPDSIPISGSNVGQRPAWTVLGSSPPKRVVSALSLAHTPPSASCPAR CDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAHAVCGTDGHTYA NVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGR NVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKK LPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGP LVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTGKDWKKRFIGIRMRTITPSLVEELKASNPD FPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIA PEVVL >XP_030287947.1 serine protease HTRA3 isoform X1 [Sparus aurata] MQIILYTAVLFYLKESVSAEPNAKCPTQCNVSTCPSPICPRGYVPDRCDCCLICAQGEGEPCGSKDDLLC GDGLDCKQPAGKRLSKSVCLCKLSYEVCGSDGKTYSSVCQLKATSRKALQQGLPGITQIHKGPCETSIGP SNAASPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNIPLSSGSGFVMSENGLIVTNAHVVSSITPVS GQQHLKVQMHNGDVYEANIKDIDKKSDIATIKINPQTKLATLFLGHSVDLRPGEFVVAIGSPFALQNTVT TGIVSTTQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITHF LNDSLNKHSKDEISTKKRFIGIRMLTITPALIEELKQQNSEFPDVTSGIFVHEVVPHSPAHKGGIKDGDI IVKLNGRPLKTTADLQKALQEETALLLEVRRDNDDLLFNIEPDIIMQ >KAB0354431.1 hypothetical protein FD755_022969 [Muntiacus reevesi] MQARALLLAALASLALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGL CRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELF LRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLP ALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGIN TLKVAAGISFAIPSDRITRFLSEFQDKTGKDWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRG GIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_043304070.1 serine protease HTRA3 [Cervus canadensis] MQARALLLAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGL CRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELF LRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLP VLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGIN TLKVAAGISFAIPSDRITRFLSEFQDKTGKDWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRG GIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_043762020.1 serine protease HTRA3 [Cervus elaphus] MQARALLLAALAALALAREPPAKSCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGL CRCRWAHAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELF LRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLP ALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGIN TLKVAAGISFAIPSDRITRFLSEFQDKTGKDWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRG GIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_018098515.1 serine protease HTRA3 [Xenopus laevis] MKLCARLPLCALLALLSLPRTETCPARCDVSRCPSPICPSGYVPDRCNCCLICAAGEGDPCGREGDPPCGDSLQCKPPAG MRGAKGTCQCKHSSPVCANDGQTYENLCQLKAASRRALQKGHSPVVLLQKGTCQSGHQHPNSPRYKFNFIADVVEKIAPA VVHIELFLRHPLFGRNVPLSSGSGFIISDLGLIVTNAHVVSSSNTVSGRQYLKVQLHNGDSYEATIKDIDKKSDIATIKI YPRKKLPVLLLGQSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLD GEVIGINTLKVAAGISFAIPSDRITKFMTESQDKKYKDGKKRFIGIKMLTITPSFAEERKQHNPDFPDVTSGIYVHGVVP NSPAQRGGIQDGDIIVKVNGRPLVTSSDLHEAVMKESPLLLEVRRGNDDMLFNLEPEVSM >KAF4013195.1 hypothetical protein G4228_004647 [Cervus hanglu yarkandensis] MHLILPASVGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTV SGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQR DGRELGLRDSDMDYIQTDAIINDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTGKDWKKRFIGIRMRTITPSLVE ELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPE VVL >XP_015827088.1 PREDICTED: serine protease HTRA3 [Nothobranchius furzeri] MRPNMFVFLRAAVFLLFTHSLTQAARYDKCDSRCDVSSCPSPSCPGGYVPDRCNCCLVCAPREGDPCGRKNDLPCADGLV CKLRPAGRLRGSKRACRCKLDHELCGSDGKTYGNVCKMKAASRKAVGRGRAAVSQAHKGPCAPPGAGHSLVRLSSPRYKF NFIADVVEKIAPAVVHIELFVRHPLFGRHVRVSSGSGFIVTHTGVIVTNAHVVTTAGTVTGRLQLRVQLHDGDAYEAVVR DVDKKADIATIKISSQKKLHVLSLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGIRDSDMDYIQTDAII NYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPADRISRFLADSQDKHSKEKAKLQRTHAEDQQSDAETSPVKKYFLGVR MITVTKVLMSELKHQNPDLPDISGGVLVQQVVPNTPAERGGIKAGDVIVKLDGQPVQTTEDIQNMLQSDRPLLLEIRRGN DDLLFNVQPQQRML >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] MGWAARPRALAPAAPKALRSSPRRCCPARAQLAAVGAAMQSSRAARLLPLLLLLLAAPAWAQPPRAGRSAPAATSPVAGC PERCEPARCAPPPTNCEGGRVRDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVSFGVPASATVRRRSQAGVCVCASNEP VCGSDANTYANLCQLRAASRRSERLQQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKR EVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGE FVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPS DKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISI NGQSVVSANDVSDVIKKDSTLNMVVRRGNEDIMITVIPEEIDP >XP_040191301.1 serine protease HTRA3 [Rana temporaria] MKGSPSCPIMLILTSLSLLCGSSACPSRCDVTRCPSPVCPSGYIPDRCNCCLICAAGEGEPCGREGDPPC GDTLHCKPPTGKRGTKGTCQCKQDYQVCANDGQTYDNLCQLKLASRRALQQGHPPVVQVHKGACQSGHQH LNSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPMSSGSGFIISDLGLIVTNAHVVSSSNTVSGR QHLKVQLHNGDTYEATIKDIDKKSDIATIKINSKKKLPVLTLGHSADLRPGEFAVAIGSPFALQNTVTTG IVSTAQRDGRELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITKFMT DTHDKKIKDGKKRFIGIKMLTITPTLVEELKLNNPDFPDVSSGIYVHEVVPNSPAQRGGIKAGDIVVKVN GRPLMTSTDLHTAVINESPLLLEVRRGNDDLLFNIEPDVSM >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] MASGNVVHFSKHRNPIVLLRRICHKEGQPGNNAKVATVARPYSQGSDQNNQNNGNKKIPITLFGAMLGISSGAVLLNKKR NSQQPSILHAAEGEDRAAGGGSSRRNNNNFIADVVEMSGSAVVFIARFARVPFMRKQVEVSHGSGFIVESQGLVITNAHV VGNQSKLKVRLQDGREFEGVVLGVDEGLDLAAVEIRSRDLPYLPLGCSNDIRPGEWVVAMGSPLNLKNTVTAGIVSNIHR AGKELGLHDHETRDMEYIQTDAMINFGNSGGPLINLDGEVIGVNSMMASAGIGFAIPVDYVKDFLTRLKEALKERRRSSS GQTRLPTGRRKYIGITMLTLTEDIVDQLRLRNPDFPNVAKGVLVHRVQYNSPADKAGVQDNDVIIKIDDKDIFSTQDVFQ ALSKSNIQLTVIRGDKTIKLRIEPEEVL >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] MAASMIRRVMQSLPIFRSKVPVFTTNRQILQSLKPQTAICRTITQQQMEKNKKQFQKRMFQYLMVIVIVAVISPYVRDLR FASFEPRRDKKRRKLQALKEAEEREKLGDNFQQTESDHNISSSDDSFRPITQEEQSSVFPVVKAAKVFDEGDGYVPPRSN RFNFIADAVDIAAPSVVYIEIQGRHPMMGRQQVSISNGSGFIVSQDGLILTNAHVVANKIRGPQSVKVKLPDGRMVDGHV VAVDSVSDLAAVKIDDGKNLPVMKLGKSSHLRPGEWVIAMGSPLTLSNTITAGIVSTVSRTSKELGLSKDIDYIQTDAAI NFGNSGGPLVNLDGEAIGINTMKVTSGISFAIPIDNAREFLEEVQKRMKSGDASQGWTGWFAGGKKSPSTQGDKRGYIGI TMLTLNPGLLNDLKSRMADFPNVSHGVLVYRIIVGSPAQVAGMKAGDIITHIDGKPVKSATAVYNAVHTLQKMEVAVVRG SSSQKLTLTLMPEEAQ >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] MAASMYRQSLKLSRLIRSNTPLLWRYSPTVNPQSTQVVISRTITQNQMHENQKIFFKRVAQFVGFGVFLYVISPWARQLK GAKFESRRDKKRRRLAAEQNEVENTSISHGVPSLNYQESSPPSRGILPVVKAADVTDFGTGYVTPRSQQFNFIADAVAKA SPSVVFIEIHGRHPYQRGVVGPISNGSGFIVSPDGLILTNAHVVANKRLGKQSVKVKLYDGRLVDGKVVAVDPVSDLALL KIDTKDPLPVMRMGNSSAARPGEWVIAMGSPLSLSNTITAGIISTVSRTSKELGLNKSIDYIQTDAAINVGNSGGPLVNL DGEAIGINTMRVTTGISFAIPIDCARDFVDKVQKQMKASGGGWFGKSGPQGPALTTPSKAGKQGYIGITMLSLTPSLIFD LRQRAPDFPNVSHGVLIYRITMESPAQVAGLKAGDIITHINDQPIKSSQELYDRVQAKESLKVTAVRGKETMKLTITPEE SQ >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] MAAPLTRTSWTVLRRNHFQYKQFLTVSCVNRFSQYKYSHQQDKKFRTSEKTVRNVLFYTIFFSGFGYVLYKWKDDCQNRF SNLIKSMFTIYAKPVSWDGGNNRNKYNFIADVVEKSAPAVVYIEIQNNRRFDFQTGKPFNISNGSGFIVESDGLILTNAH VVTAKPHTTVKVRLYDGSVYTGTVEDIDVHSDLATVRINKTNLPVMKLGSSSNLRPGEFVVAIGSPLALSNTITSGVISS VNRHSQELGLLNKQMAYIQTDAAITFGNSGGPLVNLDAEAIGINAMKVTSGISFAIPIDYAKDFLRKAELRRKNKGTQFA MEKTKTQYIGITMLTLTPDLFYELQKKLKGIPHNIRYGVLVYKVIVGSPAHLGGLQAGDIITQVNDEPVVSSASIYKAIE AAKILRMTVIRGLEVLHLRIEPEEI >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] MALRGSHRLEVIFKRCIASPVLHSHAANRRSSQLAIKEGDPNSNGNSGQYQQNGEQKEKGWRRLVRFFVPFSLGAVVSAA IIQREDLTPTIAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVI NKPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQVNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQR ASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRKKGSAYKTGYP VKRYMGITMLTLTPDILFELKSRSQNMPSNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALADNSK TLDIVILRGVKQMHVTITPEDP >CAE1315992.1 HTRA2 [Sepia pharaonis] MFVVCDGQDHLSEMAFNSVSKDGQCIDEFIYSTYKICLESSNSIAVHSGWCRRICIGSGGVYGGSPPCKKAAPAVVYIEV ANRHPYYTVLSNGSGFIVKEDGLILTNAHVVVNRHKVIVKLQDGTKVEGKVLLVDPVSDLAAIKINVAGLPILNLGESNS LRPGEWVIAMGSPLSLTNTVTSGIVSTPHRGSAELGLHHRNMTYIQTDAVINFGNSGGPLVNLDGEAIGINTLKVATGIS FAIPSDYAKGFLHKAEKDDECPTK
Mafft alignment of selected proteins >sp|P83110|HTRA3_HUMAN Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 PE=1 SV=2 ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR W---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQI -KD--------------------------WKKRFIGIRMR--------TITPSLVDELKA S--NPDFP-EVSSGIYVQ----EVAPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVM--- ----------------------- >sp|P83110-2|HTRA3_HUMAN Isoform 2 of Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR W---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQI -K------------------------------------------------APSLAVH--- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >tr|F1REI0|F1REI0_DANRE HtrA serine peptidase 3b OS=Danio rerio OX=7955 GN=htra3b PE=3 SV=3 ----------------------------------------------------------MQ V-------------------------ILC-----------VSVV--------FLYYK--- -------------------------------AAVADKL--KCPERCDVSKCPSP--SCPS GYVPDRCDCCLVCAQGEGEPCGRKDDLPCGDGLEC--------------------VCQCR Y---------SSKVCGSDGNTYG-NICQLKAVSR------------------KALQQ--- ---G--KLIQLAPLSCPL-----G-------------------------------ISPS- --------HPL---FGRTVPLSSGSGFVMSETGLIVTNAHVVSST------TSVSGHQRL KVQMRDGDVYEATIQDIDKKSDIATIKINPQKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLQD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLNDSLGKS- -----------------------------VKKRFIGIRML--------TITDALVEELKQ Q--NPDFP-DVSSGIFVH----EVVPHSP----------------AQKGG--IRDGDIIV KLNGEPLLSTSDLKEAL-NQDMTLLLE-VRRGNDDLLFNIE-----------PDIIM--- ----------------------Q >NP_084403.2 serine protease HTRA3 isoform a precursor [Mus musculus] ----------------------------------------------------------MQ A---------------------------------------RALLPATLAILATLAVLAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLEC-----------------VRGVCRCR W---------THTVCGTDGHTYA-DVCALQAASR------------------RALQV--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSSS------STASGRQQL KVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQNKHV -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA A--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LNESSLLLE-VRRGNDDLLFSII-----------PEVVM--- ----------------------- >NP_001257956.1 serine protease HTRA3 precursor [Rattus norvegicus] ----------------------------------------------------------MQ A---------------------------------------RALLPATLATLATLAVSVL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLEC-----------------VRGVCRCR W---------THTVCGTDGHTYA-DVCALQAASR------------------RALQI--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSSS------NTASGRQQL KVQLQNGDAYEATIQDIDKKSDIATILIHPNKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKHV -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKT A--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LNESSLLLE-VRRGNDDLLFSIM-----------PEVVM--- ----------------------- >XP_015141331.1 serine protease HTRA3 [Gallus gallus] ----------------------------------------------------------MR L-------------------------SLL-----------SPLL------LLCLSRSRG- -------------------------------SAELPAARAKCPTRCDVSKCPSP--SCPS GYVPDRCNCCLICAAGEGDSCGRKEDPPCGDSLDCR-YPMG--------KRFAKGVCQCK L---------SVQVCGSDGRTYD-NICQLKAVSR------------------KALQH--- ---GLPAVAQVQKGACES-----GHLQSS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSDSGLIVTNAHVVSST------NAISGRQQL KVQLQNGDTYEATIRDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITQFLTESLDKQN -KD--------------------------SKKRFIGIRML--------TITPALVEELKH N--NADFP-DVRSGIYVH----EVVPNSP----------------SHRGG--IQDGDIIV KVNGRPLMTSSDLQEAV-MNESPLLLE-VRRGNDDLLFNIE-----------PEIVM--- ----------------------- >XP_016806801.1 serine protease HTRA3 isoform X1 [Pan troglodytes] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR G---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQI -KD--------------------------WKKRFIGIRMR--------TITPSLVDELKA S--NPDFP-EVSSGIYVQ----EVAPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVM--- ----------------------- >XP_024849478.1 serine protease HTRA3 [Bos taurus] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--SCPVRCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLEC-----------------VRGLCRCR W---------ANAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >NP_001182272.1 serine protease HTRA3 precursor [Sus scrofa] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAAVEGEPCGRPVDSPCGESLEC-----------------ARGVCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFVMSESGLIVTNAHVVSST------NAVTGRQQL KVQLQNGDTYEATIKDIDKKSDIATIRIRPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRIARFLTEFQDKQG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIVV KVNGRPLADSSELQEAA-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVP--- ----------------------- >XP_024102294.1 serine protease HTRA3 isoform X1 [Pongo abelii] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR W---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQT -KD--------------------------WKKRFIGIRMR--------TITPSLVDELKA S--NPDFP-EVSSGIYVQ----EVAPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVM--- ----------------------- >XP_022271988.2 serine protease HTRA3 isoform X7 [Canis lupus familiaris] ----------------------------------------------------------MP A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAAGEGEPCGRPLDSPCGESLEC-----------------ARGVCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALEL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NAVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------RSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLTEFQDKHV -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-SVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDILFSIS-----------PEVVL--- ----------------------- >XP_003816537.4 serine protease HTRA3 isoform X1 [Pan paniscus] ----------------------------------------------------------MQ A---------------------------------------RALF------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR G---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQI -KD--------------------------WKKRFIGIRMR--------TITPSLVDELKA S--NPDFP-EVSSGIYVQ----EVAPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVM--- ----------------------- >XP_023109203.1 serine protease HTRA3 isoform X1 [Felis catus] MEVGSQAGVTSAGPPSWTWGKGWGGRAGEEGQGDP-GLSISTGRGILGTDRDAAGTGTLG A------------PERGLCPGGSSRPRPRLSGPPANP---SPAFP--RPGRPAGSRPRKA RPGGCRRGPGRGWPR-GRAVPSSEGGPRAPLSAAGPRARSVGPEGAGASPVPAP--ACPS G------------------PAARPPEPPAHVAARPSPSP---PQAAAARPQHRLGAPAGP R---------PVPRAAAAGRRPGRDAGARAAPGRAGRAGAGPGAPGRVVP--RALRR-VP V--PESPLSGRLRARPVQLLPGVRRQRGR-AVRP------PPRLAVRGEPGVRARRVPLP LGARRVRHRRA--HLRQRVRAAGGQ----PARAAALRDARAPAAEGRLPVGSPPADQPEV QVQLHRRRGGEDRAGRGPHRALPETPPVW-PQRAPVQRLGLHHVGGRPDCHQRPRGVHLQ CRLGPATAQGAAAEWRHVRGHHQRHRQEVGHRHHP----DPPQEEAP---GPAAGPLGRP AARRVCGGHRQSVCPAEHGDHGHRQHGPAGRQGAGPPGLRHGLRPDRRHHQLRELRGPPG EPGRRGH--------------------RHQHAQGCGRHLLRHPLGPHHTLPHGVPGQARQ RDVQPPLPASGQPGASTRCGPCPGTGDSPVRACQAPSYSWWPRLFSKVGSCLLISGAFLA ASTLLPFILAQPPHQRFAESRGPLRASPVPNGPTSRALGTRCSRDRCREGWSPEELLSSE NTVWFIGGPCVKTAWSQGRAGLP >XP_027827066.2 serine protease HTRA3 [Ovis aries] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRAVDSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL RVQLQDGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESALLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_004038466.1 serine protease HTRA3 isoform X1 [Gorilla gorilla gorilla] ----------------------------------------------------------MP A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--PCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLEC-----------------VRGLCRCR W---------SHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPL-----GLHQLS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIITNAHVVSSN------SAAPGRQQL KVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQREGRELGLQD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTEFQDKQI -KD--------------------------WKKRFIGIRMR--------TITPSLVDELKA S--NPDFP-EVSSGIYVQ----EVAPNSP----------------SQRGG--IQDGDIIV KVNGRPLVDSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVM--- ----------------------- >XP_020557610.1 serine protease HTRA3 [Oryzias latipes] ----------------------------------------------------------MR V-------------------------VLW-----------FSSV--------LLYLGGF- -------------------------------ANAEPKA--KCPTRCDVSSCPSP--SCPS GYVPDRCNCCLVCAGAEGEPCGRKDDLPCGDGLECK-HPAG--------KRLSKGFCQCK L---------GHRVCGSDGKTYR-NVCQLKATSR------------------AALQQ--- ---GQPGVSQTHKGPCESS---AGPSRTS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---LGRNIALSSGSGFVMTENGLIVTNAHVVSSS------SPVSGQQHL KVQMHNGDVYEATIKDIDKKSDIATIKINPQIKLPVLFLG-------QSADLRP-GEFVV AIGSPFALQNTVTT--GIVSSAQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLNDSLNKHS -KELR-----------------------PIKKRFIGIRML--------TITPALIEELKQ Q--NSDFP-NVTSGIYVH----EVVPHSP----------------AQKGG--IKDGDIIV KLNGKPLTSTSDLQAAL-QEETALLLE-IRRDNDDLLFNIE-----------PDVIM--- ----------------------Q >XP_021143900.1 serine protease HTRA3 isoform X1 [Columba livia] ----------------------------------------------------------MR V-------------------------SLL-----------SPLL------LLSLSYSPG- -------------------------------AAELLAARAKCPTRCDVSKCPSP--SCPS GYVPDRCNCCLICAAGEGDSCGRKEDPPCGDSLDCR-YPMG--------KRFAKGVCQCK L---------SAQVCGSDGRTYD-NICQLKAVSR------------------KALQH--- ---GLPAVAQVQKGACES-----GHLQSS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSDSGLIVTNAHVVSST------NAVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYVQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITQFLTESHDKQS -KD--------------------------GKKRFIGIRML--------TITPALVEELKH N--NADFP-DVRSGIYVH----EVVPNSP----------------SHRGG--IQDGDIIV KVNGRPLMTSSDLQEAV-MNESPLLLE-VRRGNDDLLFNIE-----------PEVVM--- ----------------------- >XP_017905282.1 PREDICTED: serine protease HTRA3 [Capra hircus] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRAVHSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTS -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESALLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_006017074.1 serine protease HTRA3 isoform X1 [Alligator sinensis] ----------------------------------------------------------MR G-------------------------SWL-----------SPLF------MLVLTFSPV- -------------------------------FAEPSGARGKCPARCDVSKCPSP--SCPS GYVPDHCNCCLICAAGEGDSCGRKEDPPCGDSLDCR-YPMG--------KRFAKGVCQCK L---------SYQVCGSDRRTYD-NVCQLKAVSR------------------KALQQ--- ---GLPAVIQIQKGACES-----GHLQPS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSDSGLIVTNAHVVSSS------NAISGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYVQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTESHDKQN -KD--------------------------GKKRFIGIRML--------TITPALVEELKH S--NADFP-DVRSGIYVH----EVVPNSP----------------SHRGG--IKDGDIIV KVNGRPLITTSDLQEAV-MNESPLLLE-VRRGNDDLLFNIE-----------PEVVM--- ----------------------- >XP_006270391.1 PREDICTED: serine protease HTRA3 isoform X1 [Alligator mississippiensis] ----------------------------------------------------------MR G-------------------------SWL-----------SPLF------LLVLTFSPV- -------------------------------FAEPSGARGKCPARCDVSKCPSP--SCPS GYVPDHCNCCLICAAGEGDSCGRKEDPPCGDSLDCR-YPMG--------KRFAKGVCQCK L---------SYQVCGSDGRTYD-NVCQLKAVSR------------------KALQQ--- ---GLPAVIQIQKGACES-----GHLQPS-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSDSGLIVTNAHVVSSS------NAISGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYVQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDRITRFLTESHDKQN -KD--------------------------GKKRFIGIRML--------TITPALVEELKH S--NADFP-DVRSGIYVH----EVVPNSP----------------SHRGG--IKDGDIIV KVNGRPLITTSDLQEAV-MNESPLLLE-VRRGNDDLLFNIE-----------PEVVM--- ----------------------- >XP_020770625.1 serine protease HTRA3 [Odocoileus virginianus texanus] ----------------------------------------------------------MQ AWEGVPQGARTPWPSSG--PPPEGPDSIPISGSNVGQRPAWTVLGSSPP-KRVVSALSL- -------------------------------AHTPPSA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_030287947.1 serine protease HTRA3 isoform X1 [Sparus aurata] ----------------------------------------------------------MQ I-------------------------IL------------YTAV--------LFYLKES- -------------------------------VSAEPNA--KCPTQCNVSTCPSP--ICPR GYVPDRCDCCLICAQGEGEPCGSKDDLLCGDGLDCK-QPAG--------KRLSKSVCLCK L---------SYEVCGSDGKTYS-SVCQLKATSR------------------KALQQ--- ---GLPGITQIHKGPCETS---IGPSNAA-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNIPLSSGSGFVMSENGLIVTNAHVVSSI------TPVSGQQHL KVQMHNGDVYEANIKDIDKKSDIATIKINPQTKLATLFLG-------HSVDLRP-GEFVV AIGSPFALQNTVTT--GIVSTTQRDGKELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITHFLNDSLNKHS -KDEI-----------------------STKKRFIGIRML--------TITPALIEELKQ Q--NSEFP-DVTSGIFVH----EVVPHSP----------------AHKGG--IKDGDIIV KLNGRPLKTTADLQKAL-QEETALLLE-VRRDNDDLLFNIE-----------PDIIM--- ----------------------Q >KAB0354431.1 hypothetical protein FD755_022969 [Muntiacus reevesi] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALASLAL- -------------------------------AREPPAA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_043304070.1 serine protease HTRA3 [Cervus canadensis] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAA--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_043762020.1 serine protease HTRA3 [Cervus elaphus] ----------------------------------------------------------MQ A---------------------------------------RALL------LAALAALAL- -------------------------------AREPPAK--SCPARCDVSRCPSP--RCPG GYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLEC-----------------VRGLCRCR W---------AHAVCGTDGHTYA-NVCALQAASR------------------RALQL--- ---SGTPVRQLQKGACPS-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_018098515.1 serine protease HTRA3 [Xenopus laevis] ----------------------------------------------------------MK L-------------------------CAR-----------LPLC-------ALLALLSL- ----------------------------------PRTE--TCPARCDVSRCPSP--ICPS GYVPDRCNCCLICAAGEGDPCGREGDPPCGDSLQCK-PPAG--------MRGAKGTCQCK H---------SSPVCANDGQTYE-NLCQLKAASR------------------RALQK--- ---GHSPVVLLQKGTCQS-----GHQHPN-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIISDLGLIVTNAHVVSSS------NTVSGRQYL KVQLHNGDSYEATIKDIDKKSDIATIKIYPRKKLPVLLLG-------QSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGKELGLRD---SDMDYVQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITKFMTESQDKKY -KD--------------------------GKKRFIGIKML--------TITPSFAEERKQ H--NPDFP-DVTSGIYVH----GVVPNSP----------------AQRGG--IQDGDIIV KVNGRPLVTSSDLHEAV-MKESPLLLE-VRRGNDDMLFNLE-----------PEVSM--- ----------------------- >KAF4013195.1 hypothetical protein G4228_004647 [Cervus hanglu yarkandensis] ----------------------------------------------------------MH L---------------------------------------------------IL------ -----------------------------------PAS---------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------V-----GLHQLT-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPLSSGSGFIMSEAGLIVTNAHVVSST------NTVSGRQQL KVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLG-------HSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYIQTDAIIN----------- DG-EVIGINTLKVA----------------------AGISFAIPSDRITRFLSEFQDKTG -KD--------------------------WKKRFIGIRMR--------TITPSLVEELKA S--NPDFP-AVSSGIYVQ----EVVPNSP----------------SQRGG--IQDGDIIV KVNGRPLADSSELQEAV-LTESPLLLE-VRRGNDDLLFSIA-----------PEVVL--- ----------------------- >XP_015827088.1 PREDICTED: serine protease HTRA3 [Nothobranchius furzeri] M------------------------RPN------------------------------MF V-------------------------FLR-----------AAVF--------LLFTHSL- -------------------------------TQAARYD--KCDSRCDVSSCPSP--SCPG GYVPDRCNCCLVCAPREGDPCGRKNDLPCADGLVCKLRPAG-------RLRGSKRACRCK L---------DHELCGSDGKTYG-NVCKMKAASR------------------KAVGR--- ---GRAAVSQAHKGPCAPPGAGHSLVRLS-----------SPRYKFNFIADVVEKIAPAV VHIELFVRHPL---FGRHVRVSSGSGFIVTHTGVIVTNAHVVTTA------GTVTGRLQL RVQLHDGDAYEAVVRDVDKKADIATIKISSQKKLHVLSLG-------RSADLRP-GEFVV AIGSPFALQNTVTT--GIVSTTQRDGKELGIRD---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPADRISRFLADSQDKHS -KEKAKLQRT--HAEDQQSDAE----TSPVKKYFLGVRMI--------TVTKVLMSELKH Q--NPDLP-DISGGVLVQ----QVVPNTP----------------AERGG--IKAGDVIV KLDGQPVQTTEDIQNML-QSDRPLLLE-IRRGNDDLLFNVQ-----------PQQRM--- ----------------------L >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] M--------------------GWAARPRALAPAAPKALRSSPRRCCPARAQLAAVGAAMQ S-----------------------SRAARL----------LPLL------LLLLAAPAWA QP-----------PRAGRSAP----------AATSPVA--GCPERCEPARCAPPPTNCEG GRVRDACGCCEVCGAPEGAACGLQEG-PCGEGLQCV-VSFGVPASATVRRRSQAGVCVCA S---------NEPVCGSDANTYA-NLCQLRAASR------------------RSERL--- ---QQPPVIVLQRGACGQ-----GQEDPN-----------SLRHKYNFIADVVEKIAPAV VHIELFRKLPF---SKREVPVASGSGFIVSEDGLIVTNAHVVTN------------KHRV KVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLG-------RSSELRP-GEFVV AIGSPFSLQNTVTT--GIVSTTQRGGKELGLRN---SDMDYIQTDAIINYGNSGGPLVNL DG-EVIGINTLKVT----------------------AGISFAIPSDKIKKFLTESHDRQA -KGKAI-----------------------TKKKYIGIRMM--------SLTSSKAKELKD R--HRDFP-DVLSGAYII----EVIPDTP----------------AEAGG--LKENDVII SINGQSVVSANDVSDVI-KKDSTLNMV-VRRGNEDIMITVI-----------PEEID--- ----------------------P >XP_040191301.1 serine protease HTRA3 [Rana temporaria] ----------------------------------------------------------MK G-------------------------SPS-----------CPIM-------LILTSLSL- ---------------------------------LCGSS--ACPSRCDVTRCPSP--VCPS GYIPDRCNCCLICAAGEGEPCGREGDPPCGDTLHCK-PPTG--------KRGTKGTCQCK Q---------DYQVCANDGQTYD-NLCQLKLASR------------------RALQQ--- ---GHPPVVQVHKGACQS-----GHQHLN-----------SPRYKFNFIADVVEKIAPAV VHIELFLRHPL---FGRNVPMSSGSGFIISDLGLIVTNAHVVSSS------NTVSGRQHL KVQLHNGDTYEATIKDIDKKSDIATIKINSKKKLPVLTLG-------HSADLRP-GEFAV AIGSPFALQNTVTT--GIVSTAQRDGRELGLRD---SDMDYVQTDAIINYGNSGGPLVNL DG-EVIGINTLKVA----------------------AGISFAIPSDRITKFMTDTHDKKI -KD--------------------------GKKRFIGIKML--------TITPTLVEELKL N--NPDFP-DVSSGIYVH----EVVPNSP----------------AQRGG--IKAGDIVV KVNGRPLMTSTDLHTAV-INESPLLLE-VRRGNDDLLFNIE-----------PDVSM--- ----------------------- >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] ----------------------------------------------------------MA S---------------------------------------GNVV---------------- ----------------------------------------------HFSKHRNP------ -----IVLLRRIC-HKEGQP-------------------------------GNNAKVATV A---------RPYSQGSDQNNQN-NGNKKIPITLF---GAMLGISSGAVLLNKKRNS--- ---QQPSILHAAEGED------RAAGGGS-----------SRRNNNNFIADVVEMSGSAV VFIARFARVPF---MRKQVEVSHGSGFIVESQGLVITNAHVVGN------------QSKL KVRLQDGREFEGVVLGVDEGLDLAAVEIR-SRDLPYLPLG-------CSNDIRP-GEWVV AMGSPLNLKNTVTA--GIVSNIHRAGKELGLHDHETRDMEYIQTDAMINFGNSGGPLINL DG-EVIGVNSMMAS----------------------AGIGFAIPVDYVKDFLTRLKEALK -ERRRSS--------SGQ------TRLPTGRRKYIGITML--------TLTEDIVDQLRL R--NPDFP-NVAKGVLVH----RVQYNSP----------------ADKAG--VQDNDVII KIDDKDIFSTQDVFQAL--SKSNIQLT-VIRGDKTIKLRIE-----------PEEVL--- ----------------------- >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] ----------------------------------------------------------MA A--------------------SMIRRVMQS----------LPIF---RSKVPVFTTNRQI LQ-----------------------------SLKPQTAICRTITQQQMEKNKKQFQKRMF QYLMVIVIVAVIS--------------PYVRDLRFA-------SFEPRRDKKRRKLQALK EAEEREKLGDNFQQTESDHNISS-SDDSFRPITQ-------------------EEQS--- ---SVFPVVKAAKVFD------EGDGYVP-----------PRSNRFNFIADAVDIAAPSV VYIEIQGRHPM--MGRQQVSISNGSGFIVSQDGLILTNAHVVAN--------KIRGPQSV KVKLPDGRMVDGHVVAVDSVSDLAAVKIDDGKNLPVMKLG-------KSSHLRP-GEWVI AMGSPLTLSNTITA--GIVSTVSRTSKELGLS----KDIDYIQTDAAINFGNSGGPLVNL DG-EAIGINTMKVT----------------------SGISFAIPIDNAREFLEEVQKRMK -SGDASQGWTGWFA-GGKKSPS----TQGDKRGYIGITML--------TLNPGLLNDLKS R--MADFP-NVSHGVLVY----RIIVGSP----------------AQVAG--MKAGDIIT HIDGKPVKSATAVYNAV-HTLQKMEVA-VVRGSSSQKLTLTLM---------PEEAQ--- ----------------------- >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] ----------------------------------------------------------MA A--------------------SMYRQSLKL----------SRLI---RSNTPLLWRYSPT VN-----------------------------PQSTQVVISRTITQNQMHENQKIFFKRVA QFVGFGVFLYVIS--------------PWARQLKGA-------KFESRRDKKRRRLAAEQ N---------EVENTSISHGVPSLNYQESSPPSR-------------------------- ---GILPVVKAADVTD------FGTGYVT-----------PRSQQFNFIADAVAKASPSV VFIEIHGRHPY--QRGVVGPISNGSGFIVSPDGLILTNAHVVAN--------KRLGKQSV KVKLYDGRLVDGKVVAVDPVSDLALLKIDTKDPLPVMRMG-------NSSAARP-GEWVI AMGSPLSLSNTITA--GIISTVSRTSKELGLN----KSIDYIQTDAAINVGNSGGPLVNL DG-EAIGINTMRVT----------------------TGISFAIPIDCARDFVDKVQKQMK -ASGGG-----WFGKSGPQGPALTTPSKAGKQGYIGITML--------SLTPSLIFDLRQ R--APDFP-NVSHGVLIY----RITMESP----------------AQVAG--LKAGDIIT HINDQPIKSSQELYDRV-QAKESLKVT-AVRGKETMKLTIT-----------PEESQ--- ----------------------- >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] ----------------------------------------------------------MA A----------------------------------------------------------- ------------------------------------------------------------ ---------------------------PLTRTSWTV---------------LRRNHFQYK QF--------LTVSCVNRFSQYK-YSHQQDKKFR---------TSEKTV---RNVLFYTI FFSGFGYVLYKWKDDCQNRFSNLIKSMFTIYAKPVSWDGGNNRNKYNFIADVVEKSAPAV VYIEIQNNRRFDFQTGKPFNISNGSGFIVESDGLILTNAHVVTA----------KPHTTV KVRLYDGSVYTGTVEDIDVHSDLATVRIN-KTNLPVMKLG-------SSSNLRP-GEFVV AIGSPLALSNTITS--GVISSVNRHSQELGLLN---KQMAYIQTDAAITFGNSGGPLVNL DA-EAIGINAMKVT----------------------SGISFAIPIDYAKDFLRKAELRRK NKGTQFA-------------------MEKTKTQYIGITML--------TLTPDLFYELQK K--LKGIPHNIRYGVLVY----KVIVGSP----------------AHLGG--LQAGDIIT QVNDEPVVSSASIYKAI-EAAKILRMT-VIRGLEVLHLRIE-----------PEEI---- ----------------------- >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] ----------------------------------------------------------MA L-----------------------RGSHRL----------EVIF---------------- ------------------------------------------------------------ -------KRCIAS--------------PVLHSHAAN---------------RRSSQLAIK EG--------DPNSNGNSGQYQQ-NGEQKEKGWR------------------RLVRFFVP F--SLGAVVSAAIIQREDLTPTIAASKMT-----------GRRRDFNFIADVVAGCADSV VYIEIKDTRHFDYFSGQPITASNGSGFIIEQNGLILTNAHVVIN----------KPHTMV QVRLSDGRTFPATIEDVDQTSDLATLRIQ-VNNLSVMRLG-------KSSTLRS-GEWVV ALGSPLALSNTVTA--GVISSTQRASQELGLRN---RDINYLQTDAAITFGNSGGPLVNL DG-EAIGVNSMKVT----------------------AGISFAIPIDYVKVFLERAAEKRK -KGSAYK-------------------TGYPVKRYMGITML--------TLTPDILFELKS R--SQNMPSNLTHGVLVW----KVIVGSP----------------AHSGG--LQPGDIVT HINKKEIKNSSDVYDALADNSKTLDIV-ILRGVKQMHVTIT-----------PEDP---- ----------------------- >CAE1315992.1 HTRA2 [Sepia pharaonis] ----------------------------------------------------------MF V----------------------------------------------------------- ----------------------------------------VCDGQDHLSEM--------- ------------------------------------------------------------ ----------AFNSVSKDGQCIDEFIYSTYKICL-------------------------- ---ESSNSIAVHSGWCRRICIGSGGVYGG--------------------SPPCKKAAPAV VYIEVANRHPY------YTVLSNGSGFIVKEDGLILTNAHVVVN------------RHKV IVKLQDGTKVEGKVLLVDPVSDLAAIKIN-VAGLPILNLG-------ESNSLRP-GEWVI AMGSPLSLTNTVTS--GIVSTPHRGSAELGLHH---RNMTYIQTDAVINFGNSGGPLVNL DG-EAIGINTLKVA----------------------TGISFAIPSDYAKGFLHKAEKDDE ------------------------------------------------------------ --------------------------------C--------------------------- ----------------------------------------------------PTK----- -----------------------
BMGE Cleaned alignment of selected proteins >sp|P83110|HTRA3_HUMAN Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 PE=1 SV=2 LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >sp|P83110-2|HTRA3_HUMAN Isoform 2 of Serine protease HTRA3 OS=Homo sapiens OX=9606 GN=HTRA3 LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQ-------------APSLAVH---------------------------------------------------------------------------------- >tr|F1REI0|F1REI0_DANRE HtrA serine peptidase 3b OS=Danio rerio OX=7955 GN=htra3b PE=3 SV=3 --FLYYK--AAVADKLKCPERCDVSKCPSPSCPSGYVPDRCDCCLVCAQGEGEPCGRKDDLPCGDGLEC---VCQCRYKVCGSDGNTYGNICQLKAVSRKALQQG--KLIQLAPLSCPLG--------------------ISPS---------HPLFGRTVPLSSGSGFVMSETGLIVTNAHVVSSTTSVSGHQRLKVQMRDGDVYEATIQDIDKKSDIATIKINPQKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLNDSLGKSVKKRFIGIRMLTITDALVEELKQQNPDFPDVSSGIFVHEVVPHSPAQKGGIRDGDIIVKLNGEPLLSTSDLKEALNQDMTLLLEVRRGNDDLLFNIEPDIIM >NP_084403.2 serine protease HTRA3 isoform a precursor [Mus musculus] LATLAVLALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTVCGTDGHTYADVCALQAASRRALQVSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSSTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATIVIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQNKHWKKRFIGIRMRTITPSLVEELKAANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLNESSLLLEVRRGNDDLLFSIIPEVVM >NP_001257956.1 serine protease HTRA3 precursor [Rattus norvegicus] LATLAVSVLAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTVCGTDGHTYADVCALQAASRRALQISGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSNTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATILIHPNKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKHWKKRFIGIRMRTITPSLVEELKTANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLNESSLLLEVRRGNDDLLFSIMPEVVM >XP_015141331.1 serine protease HTRA3 [Gallus gallus] LLCLSRSRGSAELPAAKCPTRCDVSKCPSPSCPSGYVPDRCNCCLICAAGEGDSCGRKEDPPCGDSLDCAKGVCQCKLQVCGSDGRTYDNICQLKAVSRKALQHGLPAVAQVQKGACESGHLQSSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSTNAISGRQQLKVQLQNGDTYEATIRDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITQFLTESLDKQSKKRFIGIRMLTITPALVEELKHNNADFPDVRSGIYVHEVVPNSPSHRGGIQDGDIIVKVNGRPLMTSSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEIVM >XP_016806801.1 serine protease HTRA3 isoform X1 [Pan troglodytes] LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRGAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_024849478.1 serine protease HTRA3 [Bos taurus] LAALAALALAREPPAASCPVRCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >NP_001182272.1 serine protease HTRA3 precursor [Sus scrofa] LAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAAVEGEPCGRPVDSPCGESLECARGVCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFVMSESGLIVTNAHVVSSTNAVTGRQQLKVQLQNGDTYEATIKDIDKKSDIATIRIRPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRIARFLTEFQDKQWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIVVKVNGRPLADSSELQEAALTESPLLLEVRRGNDDLLFSIAPEVVP >XP_024102294.1 serine protease HTRA3 isoform X1 [Pongo abelii] LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_022271988.2 serine protease HTRA3 isoform X7 [Canis lupus familiaris] LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAAGEGEPCGRPLDSPCGESLECARGVCRCRWAVCGTDGHTYANVCALQAASRRALELSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNAVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLTEFQDKHWKKRFIGIRMRTITPSLVEELKASNPDFPSVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDILFSISPEVVL >XP_003816537.4 serine protease HTRA3 isoform X1 [Pan paniscus] LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRGAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_023109203.1 serine protease HTRA3 isoform X1 [Felis catus] RPAGSRPRKSAAGPRAVGPEGAGASPVPAPACPSG------------------PAARPPEPPAHVAARPRLGAPAGPRPRAAAAGRRPGDAGARAAPGRRALRRPESPLSGRLRARPVQRRQRGRPPRLAVRGEPGVRARRVPLPLGARRVRHRRALRQRVRAAGGQ----PARAAALRDARAPAAESPPADQPEVQVQLHRRRGGEDRAGRGPHRALPETPPVW-PQRAPVQRLGPDCHQRPGVHLQCRLGPATAQGAAAEHVRGHHQRHRQEVGHRH---DPPQEEAP---GPAAGPLGRPAARVCGGHRQSVCPGLRHGLRPDRRHHQLRELRGPPQHAQGCGRHLLTLPHGVPGQARQRQPPLPSGQPGASTRPGTGDSPSKVGSLISGAFLAASTLLPFILAQPPHQRFESRGPLRASVPNGPTSRALGTRPEELL >XP_027827066.2 serine protease HTRA3 [Ovis aries] LAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRAVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLRVQLQDGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESALLLEVRRGNDDLLFSIAPEVVL >XP_004038466.1 serine protease HTRA3 isoform X1 [Gorilla gorilla gorilla] LAALAALALAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGGPLDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRELGLQDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTEFQDKQWKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVM >XP_020557610.1 serine protease HTRA3 [Oryzias latipes] --LLYLGGFANAEPKAKCPTRCDVSSCPSPSCPSGYVPDRCNCCLVCAGAEGEPCGRKDDLPCGDGLECSKGFCQCKLRVCGSDGKTYRNVCQLKATSRAALQQGQPGVSQTHKGPCESGPSRTSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLLGRNIALSSGSGFVMTENGLIVTNAHVVSSSSPVSGQQHLKVQMHNGDVYEATIKDIDKKSDIATIKINPQIKLPVLFLGQSADLRPGEFVVAIGSPFALQNTVTTGIVSSAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLNDSLNKHIKKRFIGIRMLTITPALIEELKQQNSDFPNVTSGIYVHEVVPHSPAQKGGIKDGDIIVKLNGKPLTSTSDLQAALQEETALLLEIRRDNDDLLFNIEPDVIM >XP_021143900.1 serine protease HTRA3 isoform X1 [Columba livia] LLSLSYSPGAAELLAAKCPTRCDVSKCPSPSCPSGYVPDRCNCCLICAAGEGDSCGRKEDPPCGDSLDCAKGVCQCKLQVCGSDGRTYDNICQLKAVSRKALQHGLPAVAQVQKGACESGHLQSSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSTNAVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITQFLTESHDKQGKKRFIGIRMLTITPALVEELKHNNADFPDVRSGIYVHEVVPNSPSHRGGIQDGDIIVKVNGRPLMTSSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_017905282.1 PREDICTED: serine protease HTRA3 [Capra hircus] LAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRAVHSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESALLLEVRRGNDDLLFSIAPEVVL >XP_006017074.1 serine protease HTRA3 isoform X1 [Alligator sinensis] MLVLTFSPVFAEPSGAKCPARCDVSKCPSPSCPSGYVPDHCNCCLICAAGEGDSCGRKEDPPCGDSLDCAKGVCQCKLQVCGSDRRTYDNVCQLKAVSRKALQQGLPAVIQIQKGACESGHLQPSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSSNAISGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTESHDKQGKKRFIGIRMLTITPALVEELKHSNADFPDVRSGIYVHEVVPNSPSHRGGIKDGDIIVKVNGRPLITTSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_006270391.1 PREDICTED: serine protease HTRA3 isoform X1 [Alligator mississippiensis] LLVLTFSPVFAEPSGAKCPARCDVSKCPSPSCPSGYVPDHCNCCLICAAGEGDSCGRKEDPPCGDSLDCAKGVCQCKLQVCGSDGRTYDNVCQLKAVSRKALQQGLPAVIQIQKGACESGHLQPSSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSDSGLIVTNAHVVSSSNAISGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTESHDKQGKKRFIGIRMLTITPALVEELKHSNADFPDVRSGIYVHEVVPNSPSHRGGIKDGDIIVKVNGRPLITTSDLQEAVMNESPLLLEVRRGNDDLLFNIEPEVVM >XP_020770625.1 serine protease HTRA3 [Odocoileus virginianus texanus] KRVVSALSLAHTPPSASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_030287947.1 serine protease HTRA3 isoform X1 [Sparus aurata] --LFYLKESVSAEPNAKCPTQCNVSTCPSPICPRGYVPDRCDCCLICAQGEGEPCGSKDDLLCGDGLDCSKSVCLCKLEVCGSDGKTYSSVCQLKATSRKALQQGLPGITQIHKGPCETGPSNAASPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNIPLSSGSGFVMSENGLIVTNAHVVSSITPVSGQQHLKVQMHNGDVYEANIKDIDKKSDIATIKINPQTKLATLFLGHSVDLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITHFLNDSLNKHTKKRFIGIRMLTITPALIEELKQQNSEFPDVTSGIFVHEVVPHSPAHKGGIKDGDIIVKLNGRPLKTTADLQKALQEETALLLEVRRDNDDLLFNIEPDIIM >KAB0354431.1 hypothetical protein FD755_022969 [Muntiacus reevesi] LAALASLALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_043304070.1 serine protease HTRA3 [Cervus canadensis] LAALAALALAREPPAASCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_043762020.1 serine protease HTRA3 [Cervus elaphus] LAALAALALAREPPAKSCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAATEGEPCGRPVDSPCGESLECVRGLCRCRWAVCGTDGHTYANVCALQAASRRALQLSGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_018098515.1 serine protease HTRA3 [Xenopus laevis] -ALLALLSL---PRTETCPARCDVSRCPSPICPSGYVPDRCNCCLICAAGEGDPCGREGDPPCGDSLQCAKGTCQCKHPVCANDGQTYENLCQLKAASRRALQKGHSPVVLLQKGTCQSGHQHPNSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIISDLGLIVTNAHVVSSSNTVSGRQYLKVQLHNGDSYEATIKDIDKKSDIATIKIYPRKKLPVLLLGQSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITKFMTESQDKKGKKRFIGIKMLTITPSFAEERKQHNPDFPDVTSGIYVHGVVPNSPAQRGGIQDGDIIVKVNGRPLVTSSDLHEAVMKESPLLLEVRRGNDDMLFNLEPEVSM >KAF4013195.1 hypothetical protein G4228_004647 [Cervus hanglu yarkandensis] --IL---------PAS------------------------------------------------------------------------------------------------------VGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSTNTVSGRQQLKVQLQNGDTYEATIKDIDKKSDIATIKIHPKKKLPALLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYIQTDAIIN-----------DGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKTWKKRFIGIRMRTITPSLVEELKASNPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLADSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVVL >XP_015827088.1 PREDICTED: serine protease HTRA3 [Nothobranchius furzeri] --LLFTHSLTQAARYDKCDSRCDVSSCPSPSCPGGYVPDRCNCCLVCAPREGDPCGRKNDLPCADGLVCSKRACRCKLELCGSDGKTYGNVCKMKAASRKAVGRGRAAVSQAHKGPCAPSLVRLSSPRYKFNFIADVVEKIAPAVVHIELFVRHPLFGRHVRVSSGSGFIVTHTGVIVTNAHVVTTAGTVTGRLQLRVQLHDGDAYEAVVRDVDKKADIATIKISSQKKLHVLSLGRSADLRPGEFVVAIGSPFALQNTVTTGIVSTTQRDGKELGIRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPADRISRFLADSQDKHVKKYFLGVRMITVTKVLMSELKHQNPDLPDISGGVLVQQVVPNTPAERGGIKAGDVIVKLDGQPVQTTEDIQNMLQSDRPLLLEIRRGNDDLLFNVQPQQRM >XP_008268840.1 PREDICTED: serine protease HTRA1 [Oryctolagus cuniculus] LLLLAAPAWAATSPVAGCPERCEPARCAPPNCEGGRVRDACGCCEVCGAPEGAACGLQEG-PCGEGLQCQAGVCVCASPVCGSDANTYANLCQLRAASRRSERLQQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKKDSTLNMVVRRGNEDIMITVIPEEID >XP_040191301.1 serine protease HTRA3 [Rana temporaria] -LILTSLSL--LCGSSACPSRCDVTRCPSPVCPSGYIPDRCNCCLICAAGEGEPCGREGDPPCGDTLHCTKGTCQCKQQVCANDGQTYDNLCQLKLASRRALQQGHPPVVQVHKGACQSGHQHLNSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPMSSGSGFIISDLGLIVTNAHVVSSSNTVSGRQHLKVQLHNGDTYEATIKDIDKKSDIATIKINSKKKLPVLTLGHSADLRPGEFAVAIGSPFALQNTVTTGIVSTAQRDGRELGLRDSDMDYVQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITKFMTDTHDKKGKKRFIGIKMLTITPTLVEELKLNNPDFPDVSSGIYVHEVVPNSPAQRGGIKAGDIVVKVNGRPLMTSTDLHTAVINESPLLLEVRRGNDDLLFNIEPDVSM >XP_039270049.1 serine protease HTRA2, mitochondrial-like [Styela clava] ----------------------HFSKHRNP---------IVLLRRIC-HKEGQP---------------NNAKVATVAYSQGSDQNNQNNGNKKIPITLKKRNSQQPSILHAAEGED--AAGGGSSRRNNNNFIADVVEMSGSAVVFIARFARVPFMRKQVEVSHGSGFIVESQGLVITNAHVVGN------QSKLKVRLQDGREFEGVVLGVDEGLDLAAVEIR-SRDLPYLPLGCSNDIRPGEWVVAMGSPLNLKNTVTAGIVSNIHRAGKELGLHDRDMEYIQTDAMINFGNSGGPLINLDGEVIGVNSMMASAGIGFAIPVDYVKDFLTRLKEALGRRKYIGITMLTLTEDIVDQLRLRNPDFPNVAKGVLVHRVQYNSPADKAGVQDNDVIIKIDDKDIFSTQDVFQAL-SKSNIQLTVIRGDKTIKLRIEPEEVL >XP_038046351.1 serine protease HTRA2, mitochondrial-like [Patiria miniata] VPVFTTNRQSLKPQTARTITQQQMEKNKKQKRMFQYLMVIVIVAVIS--------------PYVRDLRFRRKLQALKEQQTESDHNISSSDDSFRPITQ-EEQSSVFPVVKAAKVFD--GDGYVPPRSNRFNFIADAVDIAAPSVVYIEIQGRHPMGRQQVSISNGSGFIVSQDGLILTNAHVVAN--KIRGPQSVKVKLPDGRMVDGHVVAVDSVSDLAAVKIDDGKNLPVMKLGKSSHLRPGEWVIAMGSPLTLSNTITAGIVSTVSRTSKELGLS-KDIDYIQTDAAINFGNSGGPLVNLDGEAIGINTMKVTSGISFAIPIDNAREFLEEVQKRMDKRGYIGITMLTLNPGLLNDLKSRMADFPNVSHGVLVYRIIVGSPAQVAGMKAGDIITHIDGKPVKSATAVYNAVHTLQKMEVAVVRGSSSQKLTLTPEEAQ >XP_001197113.4 serine protease HTRA2, mitochondrial [Strongylocentrotus purpuratus] TPLLWRYSPPQSTQVVRTITQNQMHENQKIKRVAQFVGFGVFLYVIS--------------PWARQLKGRRRLAAEQNENTSISHGVPSNYQESSPPSR-----GILPVVKAADVTD--GTGYVTPRSQQFNFIADAVAKASPSVVFIEIHGRHPYRGVVGPISNGSGFIVSPDGLILTNAHVVAN--KRLGKQSVKVKLYDGRLVDGKVVAVDPVSDLALLKIDTKDPLPVMRMGNSSAARPGEWVIAMGSPLSLSNTITAGIISTVSRTSKELGLN-KSIDYIQTDAAINVGNSGGPLVNLDGEAIGINTMRVTTGISFAIPIDCARDFVDKVQKQMGKQGYIGITMLSLTPSLIFDLRQRAPDFPNVSHGVLIYRITMESPAQVAGLKAGDIITHINDQPIKSSQELYDRVQAKESLKVTAVRGKETMKLTITPEESQ >XP_624354.1 serine protease HTRA2, mitochondrial [Apis mellifera] -------------------------------------------------------------PLTRTSWTRRNHFQYKQVSCVNRFSQYKYSHQQDKKFRRNVLFGFGYVLYKWKDDCQNIKSMFTNNRNKYNFIADVVEKSAPAVVYIEIQNNRRFTGKPFNISNGSGFIVESDGLILTNAHVVTA----KPHTTVKVRLYDGSVYTGTVEDIDVHSDLATVRIN-KTNLPVMKLGSSSNLRPGEFVVAIGSPLALSNTITSGVISSVNRHSQELGLLNKQMAYIQTDAAITFGNSGGPLVNLDAEAIGINAMKVTSGISFAIPIDYAKDFLRKAELRRTKTQYIGITMLTLTPDLFYELQKKLKGIPNIRYGVLVYKVIVGSPAHLGGLQAGDIITQVNDEPVVSSASIYKAIEAAKILRMTVIRGLEVLHLRIEPEEI- >NP_001262565.1 HTRA2-related serine protease, isoform B [Drosophila melanogaster] -----------------------------------------KRCIAS--------------PVLHSHAARSSQLAIKENSNGNSGQYQQNGEQKEKGWRRLVRFSLGAVVSAAIIQREDAASKMTGRRRDFNFIADVVAGCADSVVYIEIKDTRHFSGQPITASNGSGFIIEQNGLILTNAHVVIN----KPHTMVQVRLSDGRTFPATIEDVDQTSDLATLRIQ-VNNLSVMRLGKSSTLRSGEWVVALGSPLALSNTVTAGVISSTQRASQELGLRNRDINYLQTDAAITFGNSGGPLVNLDGEAIGVNSMKVTAGISFAIPIDYVKVFLERAAEKRPVKRYMGITMLTLTPDILFELKSRSQNMPNLTHGVLVWKVIVGSPAHSGGLQPGDIVTHINKKEIKNSSDVYDALDNSKTLDIVILRGVKQMHVTITPEDP- >CAE1315992.1 HTRA2 [Sepia pharaonis] ----------------VCDGQDHLSEM---------------------------------------------------NSVSKDGQCIDFIYSTYKICL-----ESSNSIAVHSGWCRRGGVYGG---------SPPCKKAAPAVVYIEVANRHPY---YTVLSNGSGFIVKEDGLILTNAHVVVN------RHKVIVKLQDGTKVEGKVLLVDPVSDLAAIKIN-VAGLPILNLGESNSLRPGEWVIAMGSPLSLTNTVTSGIVSTPHRGSAELGLHHRNMTYIQTDAVINFGNSGGPLVNLDGEAIGINTLKVATGISFAIPSDYAKGFLHKAEKDD-------------------------------------------------------------------------------------------------PTK--
PhyML tree of selected proteins (XP_624354_1_serine_protease_HTRA2__mitochondrial__Apis_mellifera_:0.59817639,NP_001262565_1_HTRA2_related_serine_protease__isoform_B__Drosophila_melanogaster_:0.65133167,((XP_039270049_1_serine_protease_HTRA2__mitochondrial_like__Styela_clava_:1.02731948,(XP_008268840_1_PREDICTED__serine_protease_HTRA1__Oryctolagus_cuniculus_:0.49173511,(((XP_023109203_1_serine_protease_HTRA3_isoform_X1__Felis_catus_:11.70302569,(((XP_015141331_1_serine_protease_HTRA3__Gallus_gallus_:0.02200862,XP_021143900_1_serine_protease_HTRA3_isoform_X1__Columba_livia_:0.00553393):0.03293887,(XP_006017074_1_serine_protease_HTRA3_isoform_X1__Alligator_sinensis_:0.00488377,XP_006270391_1_PREDICTED__serine_protease_HTRA3_isoform_X1__Alligator_mississippiensis_:0.00000001):0.02599786):0.04847707,(XP_015827088_1_PREDICTED__serine_protease_HTRA3__Nothobranchius_furzeri_:0.41330471,(tr_F1REI0_F1REI0_DANRE_HtrA_serine_peptidase_3b_OS_Danio_rerio_OX_7955_GN_htra3b_PE_3_SV_3:0.15882388,(XP_020557610_1_serine_protease_HTRA3__Oryzias_latipes_:0.07079429,XP_030287947_1_serine_protease_HTRA3_isoform_X1__Sparus_aurata_:0.11559687):0.05265227):0.0536801):0.11369232):0.02930165):0.0000001,(((XP_022271988_2_serine_protease_HTRA3_isoform_X7__Canis_lupus_familiaris_:0.02034515,(NP_001182272_1_serine_protease_HTRA3_precursor__Sus_scrofa_:0.0284576,((KAB0354431_1_hypothetical_protein_FD755_022969__Muntiacus_reevesi_:0.0025069,XP_043304070_1_serine_protease_HTRA3__Cervus_canadensis_:0.00250731):0.00000001,(XP_024849478_1_serine_protease_HTRA3__Bos_taurus_:0.00250733,(XP_043762020_1_serine_protease_HTRA3__Cervus_elaphus_:0.00252123,((KAF4013195_1_hypothetical_protein_G4228_004647__Cervus_hanglu_yarkandensis_:0.01302535,XP_020770625_1_serine_protease_HTRA3__Odocoileus_virginianus_texanus_:0.01594736):0.00744888,(XP_027827066_2_serine_protease_HTRA3__Ovis_aries_:0.00498476,XP_017905282_1_PREDICTED__serine_protease_HTRA3__Capra_hircus_:0.00249596):0.00501656):0.00000001):0.00000001):0.00000001):0.01076838):0.00930543):0.00956231,((XP_016806801_1_serine_protease_HTRA3_isoform_X1__Pan_troglodytes_:0.00000001,XP_003816537_4_serine_protease_HTRA3_isoform_X1__Pan_paniscus_:0.00000001):0.00254706,(XP_004038466_1_serine_protease_HTRA3_isoform_X1__Gorilla_gorilla_gorilla_:0.00254537,((sp_P83110_HTRA3_HUMAN_Serine_protease_HTRA3_OS_Homo_sapiens_OX_9606_GN_HTRA3_PE_1_SV_2:0.00000001,XP_024102294_1_serine_protease_HTRA3_isoform_X1__Pongo_abelii_:0.00000001):0.00000001,sp_P83110_2_HTRA3_HUMAN_Isoform_2_of_Serine_protease_HTRA3_OS_Homo_sapiens_OX_9606_GN_HTRA3:0.01336139):0.00000001):0.00000001):0.04248277):0.00995261,(NP_084403_2_serine_protease_HTRA3_isoform_a_precursor__Mus_musculus_:0.01031362,NP_001257956_1_serine_protease_HTRA3_precursor__Rattus_norvegicus_:0.01518308):0.03556181):0.16795449):0.01491775,(XP_040191301_1_serine_protease_HTRA3__Rana_temporaria_:0.09984794,XP_018098515_1_serine_protease_HTRA3__Xenopus_laevis_:0.08277243):0.06831755):0.26457553):0.76161908):0.25309639,(CAE1315992_1_HTRA2__Sepia_pharaonis_:1.11920407,(XP_001197113_4_serine_protease_HTRA2__mitochondrial__Strongylocentrotus_purpuratus_:0.42367048,XP_038046351_1_serine_protease_HTRA2__mitochondrial_like__Patiria_miniata_:0.33578764):0.34437352):0.17893079):0.39360836);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)