PB0167

DATABASE

Click here to access PB0167 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0167	Q66K79	Carboxypeptidase Z	CPZ		Homo_sapiens	Cleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.

Domains

Gene Ontology

PF00246 (Peptidase_M14) PF01392 (Fz)

GO:0004180 (enables) carboxypeptidase activity GO:0004181 (enables) metallocarboxypeptidase activity GO:0008233 (enables) peptidase activity GO:0008237 (enables) metallopeptidase activity GO:0008270 (enables) zinc ion binding GO:0016787 (enables) hydrolase activity GO:0046872 (enables) metal ion binding GO:0006508 (involved in) proteolysis GO:0006518 (involved in) peptide metabolic process GO:0016055 (involved in) Wnt signaling pathway GO:0016485 (involved in) protein processing GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q66K79|CBPZ_HUMAN Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ PE=1 SV=2 MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP EEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >sp|Q66K79-2|CBPZ_HUMAN Isoform 2 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ MPPPLPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWE VVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQP AFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYA QMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNE VAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTS GRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTI PFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSEN RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHN KESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIV IAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLG EATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >sp|Q66K79-3|CBPZ_HUMAN Isoform 3 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLN FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >tr|F6P711|F6P711_DANRE Carboxypeptidase Z OS=Danio rerio OX=7955 GN=cpz PE=3 SV=1 MDNKMLTLLILLNALATCLSFPQRCTQEEAAIGRCRTPAEEGPQCIEMVLGYCQDVPYTH TTFPNIVGHRTRQDLEMGAEYLLLSVIHGLMKGECSPDIRILGCSVLAPRCENGRLMKPC RSSCEMLKKSCIHAFEAIQMAWPYFLDCDRFFVGSEEGCYDPLSELREKQEVALANISDG GLSTVIQFTYHSNSQMFSILKKTASKCSHISQTYSIGRSVEGKDLLVIEFSNNPGQHDLL EPEIKLIGNMHGNEVLGRQLLIYLAQYLCSEYLLGNERIQTIINTTRIHILASMNPDGYE IAASEGHEYNGWTSGRANAQNLDLNRNFPDLTSIFYNRRRFRHFRSDHIPIPDSYWMNKV VAPETYAIMKWIRTYPFVISASLHGGELVISYPFDFSRHPQEDRMYSPTPDEQIFRQLAR TYADAHATMSNNDTERCGASFANKGGITNGALWYSFAGGMSDFNYLHSNCYEITVELGCD KFPSEEELYPEWRRNKEALLSFMESVHKGIKGIVKDEHGNGIKGAIISVKGLRHDITTAE DGDYWRLMNPGVHIVTASASGYSKQSKRINLPRNTQVGRVDFVLKKVPREPSLDYFNIPE LDNYERFDPFNQFEQYSQRELGEDGEERTEKPWWWGYFSQLGMSAPTWLLRNY
Selected proteins from model organisms >sp|Q66K79|CBPZ_HUMAN Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ PE=1 SV=2 MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTT FPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRH ICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPP TFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPE VKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAA AEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPE TKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPP EEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDY WRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGP HDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >sp|Q66K79-2|CBPZ_HUMAN Isoform 2 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ MPPPLPLLLLTVLVVAAARPGCEFERNPAATCVDLQLRTCSDAAYNHTTFPNLLQHRSWE VVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQP AFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYA QMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNE VAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTS GRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTI PFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSEN RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHN KESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIV IAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLG EATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >sp|Q66K79-3|CBPZ_HUMAN Isoform 3 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ MAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVL RRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREM LIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQ NLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSA SLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNF LKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLN FVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPG YAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPD PLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY >tr|F6P711|F6P711_DANRE Carboxypeptidase Z OS=Danio rerio OX=7955 GN=cpz PE=3 SV=1 MDNKMLTLLILLNALATCLSFPQRCTQEEAAIGRCRTPAEEGPQCIEMVLGYCQDVPYTH TTFPNIVGHRTRQDLEMGAEYLLLSVIHGLMKGECSPDIRILGCSVLAPRCENGRLMKPC RSSCEMLKKSCIHAFEAIQMAWPYFLDCDRFFVGSEEGCYDPLSELREKQEVALANISDG GLSTVIQFTYHSNSQMFSILKKTASKCSHISQTYSIGRSVEGKDLLVIEFSNNPGQHDLL EPEIKLIGNMHGNEVLGRQLLIYLAQYLCSEYLLGNERIQTIINTTRIHILASMNPDGYE IAASEGHEYNGWTSGRANAQNLDLNRNFPDLTSIFYNRRRFRHFRSDHIPIPDSYWMNKV VAPETYAIMKWIRTYPFVISASLHGGELVISYPFDFSRHPQEDRMYSPTPDEQIFRQLAR TYADAHATMSNNDTERCGASFANKGGITNGALWYSFAGGMSDFNYLHSNCYEITVELGCD KFPSEEELYPEWRRNKEALLSFMESVHKGIKGIVKDEHGNGIKGAIISVKGLRHDITTAE DGDYWRLMNPGVHIVTASASGYSKQSKRINLPRNTQVGRVDFVLKKVPREPSLDYFNIPE LDNYERFDPFNQFEQYSQRELGEDGEERTEKPWWWGYFSQLGMSAPTWLLRNY >XP_038948430.1 carboxypeptidase Z isoform X1 [Rattus norvegicus] MHRSKSCYRKSFRVCSAPGVLTSDQGCLTDTHFLTETGHTGKCQRLASTHSATCVDLHLRTCADAAYNHT SFPTPLEHRSWEAVEASPEYTLLGVLHFLLEGQCNPDLRLLGCSVLAPRCQGGHTQRPCRRVCEGLREAC QPAFDAIDMAWPYFLDCTQYFAPEEEGCYDPLEQLRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKR TAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEY LLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTR GVRTDHIPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKHPHEEKMFSPTPDEK MFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFP PEEALYGLWQHNKEPLLNFLEMVHRGIKGVVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSH IVIAQAPGYSKVMKRVTIPLRMKRAGRVDFILQPLGTGPKNFLPGPSRALPRSLDPQGAPAQLDFEPPRA RRQPASGSKPWWWAYFTSLSPHKPRWLLKY >NP_694747.2 carboxypeptidase Z precursor [Mus musculus] MPTMPLLLAALAALAVLALAARPSPSCSPGPDPSGKCQRLVYTHSATCVDLHLRTCADAAYNHTSFPTPL EHRSWEAVESSPEYMLLGVIHFLLEGQCNPDLRLLGCSVLAPRCEGGHTQRPCRHVCEGLREACQPAFDA IDMAWPYFLDCAQYFAPEEEGCYDPLEELRGELDVEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCS QVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLLGNPR IQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDH IPISQYYWWGKVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPHEKKMFSPTPDEKMFKLLA RAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALY GLWQQNKEPLLNFLEMVHRGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQA PGYSKVMKRVTIPLRMKKAGRVDFILHPLATGPKNFLPGPSRALPRFQDPQREPTQMDFEPPRARRQPAS GSKPWWWAYFTSLSPYKPRWLLKY >NP_989909.3 carboxypeptidase Z precursor [Gallus gallus] MVPSLLLLLTGLFRATEPAPRCETGQETLGQCQAAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVI EYSSEYILISVLHNLLQGECNPDLRLLGCSVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYF LDCDRFFAGEEEGCFDPLAKLRGEVAVEEDLPSDFPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSI GRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNT RIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYW WGKVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKMFKMLAKAYADAHP VISDRSEHRCGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRD ALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDITTAADGDYWRLLPPGTYIVTAQAMGYTKVMK RVTLPIKMKRAGRVDFVLRPIEIWPNKLLRRPMEDMYDQYDPLELFDPHTQHAQARGGSQQVREKPWWWS YFSSLDLHKPLWLLKQH >NP_001289340.1 carboxypeptidase Z precursor [Pan troglodytes] MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCMDLQLRTCSDAAYNHTTFPNLLQHRSW EVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAW PYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVART YSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLL NTTRIHLLPSMNPDGYEVAAAEGAGYNGWTGGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQ HYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQEEKMFSPTPDEKMFKLLSRAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQH NKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVIIPTRMKRAGRVDFILQPLGLESKNFFHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGS KPWWWSYFTSLSTHRPRWLLKY >XP_038322250.1 carboxypeptidase Z isoform X1 [Canis lupus familiaris] MQLRTCSDVAYNWTTFPTLLEQRSREAVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVR RPCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASVEEGCYDPLEKLREGLDAEEALPSGLPPTFIHF THHSYAQMVRVLRRTAARCAHVAKTYSIGRSFNGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAGR EMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNF PDLTSEYYRLASSRSVRSDHIPIPQHYWWGKVAPETKAIMKWMRTTPFVLSASLHGGDLVVSYPFDFSKH PQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSN CFEITVELGCVKFPPEEALYTLWQHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARILVKGIRHDITTA PDGDYWRLLPPGPHIVIAQAPGYSKVIKKVTIPARMKRAGRVDFILQPLGTGPKKVLLGPRRSGSGLRDP LGGASPYGEPEEVGQEPLGGRRQPSSGGSKPWWWSYFTSLSQHKPRWLLKY >NP_001076955.1 carboxypeptidase Z precursor [Bos taurus] MRPPPPLLLTMLVLAAARPGCEPAWDPEGGCPRSAAADSAMCVDLQLQTCSDVTYNRTAFPTLLQHRSRE AVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWP YFLDCGRYFSGPEEGCYDPLEKLRGGLDIEEALPSGHPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTY SIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLFYLAQYLCSEYLLGSPRIQRLLN TTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSNHIAIPQH YWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDDKMFKLLARAYADV HPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCMKFPPEEALYTIWQHN KEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKV IKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGGLGGEPQEPDEEPLGARRQPTTGGSKPWWWSYF TSLGQHQPRWLLKY >XP_024102119.1 carboxypeptidase Z isoform X1 [Pongo abelii] MPPPPPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSR EVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREACQPAFDAIDMAW PYFLNCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVART YSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLL NTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQ HYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQH NKESLLNFVEMVHRGIKGVVTDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGVHIVIAQAPGYAK VIKKVIIPTRMKRAGRVDFILQPLGMGPKNFLHGLQRTGPHDPLGGASSLGEATEPDPLRARRQPSADGS KPWWWSYFTSLSTHRPRWLLKY >XP_010708822.1 carboxypeptidase Z [Meleagris gallopavo] MVPSLLLLLTGLFRATEPAPRCETGQETLGQCQTAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVI EYSSEYILISVLHNLLQGECNPDLRLLGCSVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYF LDCDRFFAGEEEGCFDPLAKLRGEVVVEEDLPSDLPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSI GRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNT RIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYW WGKVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKLRISGKLGFLLLSP AVREWIRPTSRSLPEPVPRSCSSAHESPREAPRLEYFRGWAPG >XP_034807806.1 carboxypeptidase Z isoform X1 [Pan paniscus] MPPPPPLLLLTVLVVVAARPGCEFERNPAGECHRPPAADSATCMDLQLRTCSDAAYNHTTFPNLLQHRSW EVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAW PYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVART YSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLL NTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQ HYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQEEKMFSPTPDEKMFKLLSRAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQH NKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVIIPTRMKRAGRVDFILQPLGLGSKNFLHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGS KPWWWSYFTSLSTHRPRWLLKY >XP_003985597.3 carboxypeptidase Z [Felis catus] MAWPYFLDCGSYFASVEEGCHDPLEKLRGGLDAEEALPSGPPPTFIHFTHHSYAQMVRVLRRTAARCAHI AKTYSIGRSFDGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQ RLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEFYRLEASGSIRSSRIP IPQHYWWGKVAPETKAIIKWMRTTPFVLSASLHGGDLVVSYPFDLSKHSQEEKFSPTPDEKMFKLLARAY ADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIW QHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGSHIVIAQAPGY SKVIKKVTIPARMKRAGRVDFILQPLGTGPKKFLLGPRRSGSAVRDPLGGASPYGEPQEPGQEPLGARRQ PSAGGSKPWWWSYFTSISQHKPRWLLKY >XP_027827070.1 carboxypeptidase Z [Ovis aries] MRPPPPLLLTMLVLAAARPGCEPAWDPEGACSGPAAADSATCVDLQLQTCSDVTYNRTAFPTLLQHRTRA AVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWP YFLDCGRYFSGPEEGCYDPLEKLRGGLDVEEALPSGYPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTY SIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLN TTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHIAIPQH YWWGKVAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADV HPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHN KEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKV IKKVIIPSRMKRAGRVDFILQPLRTGPHKFLPGSRRGGLGGEPQEPDQEPLGARRQPTTGGSKPWWWSYF TSLGQHQPRWLLKY >XP_030866357.1 carboxypeptidase Z [Gorilla gorilla gorilla] MPPPPPPPPPLLLLTVLVVAAARPGCEFERKPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQ HRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAI DMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAH VARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRI QRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI PIPQHYWWGKVAPETKAVMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSR AYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYT LWQHNKESLLNFMEMVHRGIKGVVTDKFGKPLKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIVQAP GYAKVIKKVIIPTRMKRAGRVDFILQPLGMGPKNFLHGLQRTGPHDPLGGASSLGEATEPDPLRARRQPS ADGNKPWWWSYFTSLSTHRPRWLLKY >XP_023816686.1 carboxypeptidase Z isoform X1 [Oryzias latipes] MSPDVLPPLLLLLWTSAPCWCAPQHTCHPGDELLGRCSTGARQDRAACTELNLGYCNDLDYSRTIFPNIL GHQSRVEAESGAEYLLLSVIHGLLNGECSPEIRLVGCSVLASPCRDDKMIKPCRRTCEALRKDCSHAFEA IEMAWPYFLDCDRFFASDQEGCFDPLAGLKAKQELALSSLSPEEPSTIIQFTYTSNSQMYSLLKRTAAKC AHISHVYSIGRSTEGRDLLVIEFTNNPGQHELLEPEVKMVGNMHGNEVLGRQLLIYLAQYLCSEYNLGNQ RIQSIINSTRIHILASMNPDGYELASSEVEDNSERDLNNQEGHLLNGWTNGRSNAQNIDLNRNFPDLTSI FYRNRRSRHYRTDHIPIPDGYWFGKVAPETYAVMKWIRSLPFVQSASLHGGELVVSYPFDFSRHPQEERM FSPTPDEQAFKQMARTYADAHATMSNNDTDRCGASFYWNRGIINGALWYSFAGGMSDFNYLHTNCMEITV ELGCDKFPPEAELYPEWKRNKEALLSFLESVHRGIKGEVKDTDGNGIKGATVSVRGIRKDVTTAEDGDYW RLLNPGTYIVTATAKGYSKVSKRVHLPHRMNKAGRVDFVLEKVPVEPGIEDHLFPTVDSWERFDPYNQFE RFSEGDGGVERQEKPWWWNYFSQSGISPPTWLLRNV >XP_005498499.1 carboxypeptidase Z [Columba livia] MVLRLLLLLAGLLRATKPAPRCETGQETLGQCQSVQKAKCVDITLSSCTDVAYTQTMYPNFLDQKTREVI EYSSEYILISVLHNLLQGECNPDLRLLGCSVLAPQCEKDKVIKPCRHVCENLKKNCLPAFDAIDMAWPYF LDCDRFFAGEEEGCFDPLAKLRGEVDVEEDLPSDLPGTFIQFKHHSYSQMVSTLKKTASKCSHIATTYSI GRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNT RIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAEIRGARLDHIPIPQSYW WGKVAPETKAVMKWLRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKMFSPTPDEKMFKMLAKAYADAHP VISDRSEHRCGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRD ALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDVTTAADGDYWRLLPPGTYIISAQASGYSRVIK RVTIPAKMKQAGRVDFVLRPAEAWPNKLLRRSMEDMYDPYDPLELFDPHAQHRQAEARGGSPPGREKPWW WSYFSSLGLHKPLWLLKQR >XP_017905285.1 PREDICTED: carboxypeptidase Z [Capra hircus] MRPPPPLLLTMLVLAAARPGCEPAWDPEGACSRSVAADSATCVDLQLQTCSDVTYNRTAFPTLLQHRTRA AVESSSEYILLSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWP YFLDCGRYFSGPEEGCYDPLEKLRGGLDIEEALPSGYPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTY SIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLN TTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHIAIPQH YWWGKVAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADV HPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHN KEPLLNFVEMVHRGIKGMVMDKFGKPVKNARILVKGIRHAITTAPDGDYWRLLPPGAHIVIAQAPGYSRV IKKVIIPSRMKRAGRVDFILQPLRTGPQKFLPGSRRGGLGGEPQEPDQEPLGARRQPTTGGSKPWWWSYF TSLGQHQPRWLLKY >XP_006017072.1 carboxypeptidase Z [Alligator sinensis] MLLHILLFLGALAKVTEPAPRCETGQETLGQCQAEQKAKCVDITVGTCNDVPYSKTMYPNLLDQKARQAV EYSSEYILISVIHNLLQGECNPDLRLLGCSILAPQCEKDKIIKPCRHICEKLKKSCLPAFDAIDMAWPYF LDCDRFFAGEEEGCFDPLAKLRGELEVAEEDPLAGLPTTFIQFTHHSYSQMVSILKRTASKCSHIARTYS IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQMLINH TRIHLLPSLNPDGYDLAAEEGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHIPIPQSY WWGKVAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPLEEKMFSPTPDEKMFKLLAKAYADAH PIISDKSEIRCGGSFGKRGGIINGAEWYSFPGGMADFNYLHTNCFEITVEVGCEKFPLEEELYSIWHENR ESLLNFIEMVHRGIKGIVSDKLGNPIKNARISVRGIRHDVTTADDGDYWRLLPPGTYIISAHAVGYSKVI KKVTLPVKMKRAGRVDFVLRPSEFWPNKFLRRPMEAMRDQYDPLEHFDPHAQHAQPGQRNERGDLTRNRE RPWWWSYFSSLDQHKPMWLLKRN >XP_006264271.1 PREDICTED: carboxypeptidase Z [Alligator mississippiensis] MLLHILLFLGALAKVTEPAPRCETGQETLGQCQTEQKAKCVDITVGTCNDVPYSKTMYPNLLDQKARQAV EYSSEYVLISVIHNLLQGECNPDLRLLGCSILAPQCEKDKIIKPCRHICEKLKKSCLPAFDAIDMAWPYF LDCDRFFAGEEEGCFDPLAKLRGELEVAEEDPLAGLPTTFIQFTHHSYSQMVSILKRTASKCSHIARTYS IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQMLINH TRIHLLPSLNPDGYDLAAEEGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHIPIPQSY WWGKVAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPLEEKMFSPTPDEKMFKLLAKAYADAH PIISDKSEIRCGGSFGKRGGIINGAEWYSFPGGMADFNYLHTNCFEITVEVGCEKFPLEEELYSIWHENR ESLLNFIEMVHRGIKGIVSDKLGNPIKNARISVRGIRHDITTADDGDYWRLLPPGTYIISAHAVGYSKVI KKVTLPVKMKRAGRVDFVLRPSEFWPNKFLRRPMEAMRDQYDPLEHFDPHAQHAQPGQRNERGDLTRNKE RPWWWSYFSSLGQHKPMWLLKRN >XP_015827050.1 PREDICTED: carboxypeptidase Z-like isoform X1 [Nothobranchius furzeri] MRLELLALSLLLTGCCCVPQRRCHPGDEFLGMCSSAQEVTPTCTEMNLGYCNDVEYTRTIFPNILGHRSR LEVESGAEYLLLSVIHALLNGECSPEIRLVGCSVLASPCRDNKMIKPCRSTCEALRKDCRHAFDAIEMAW PYFLDCDRFFASEEEGCFDPLAGLKARQELALSSLSPEEPSTIIQFTYTSNAQMYSLLKRTAAKCSHISH VYSIGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLGRQLLIYLAQYLCSEYILGNQRIQTI INTTRIHILASMNPDGYELAASEVEDSNDPELSNQEGHLLNGWTNGRTNAQNLDLNRNFPDLTSIFYRNR RSRHYRSDHIPIPDSYWFSKVAPETYAVMKWIRSLPFVQSASLHGGELVISYPFDFSKHPHEEKMFSPTP DEQVFKQLARTYADAHATMSNNDTDRCGASFYRNRGIINGALWYSFAGGMSDFNYLHTNCMEITVELGCD KFPSEAELYPEWKRNKEALLSFLESVHRGIKGVVKDLDGNGIKGATVSVRGIRRDVTTAEDGDYWRLLNP GTHILTATAKGFSKVSKRVYLPHNMNKAGLVDFVLEKVPVEPDINDHLFPTTDTWDRFDPYNQFERYSSP DVAEGDVEREEKPWWWNYFSQSGISPPNWLLRNV >XP_020745074.1 carboxypeptidase Z [Odocoileus virginianus texanus] MWESGENWISCRKLESSPVDVFTPRRLASSPSGCPSSAAADSAMCVDLQLQSCSDVAYNRTAFPTLLQHR SHVGYWLERQPDVSERGPGNRGLDIEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGR SFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRI HLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWG KVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKLPPPHWAAGMSDFNYL HSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDI TTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGWPGG EPQEPDQDPLGARRQPTTGGSKPWWWSYFTSLGQHQPRWLLKY >XP_043304186.1 carboxypeptidase Z [Cervus canadensis] MRPPPPLLLTMLVLTAARPGCEPAWGPEGGCPGSAAADSATCVDLQLQSCSDVAYNRTAFPTLLQHRSRAAVESSPEYVL LSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDPL EKLRGGLDIEEALPSSYPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEV KLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDL NRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKM FSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPE EALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKV IKKVIIPSRMKRAGRVDFILQPLRTGPQKFLPGSRRGWPGEEPQEPDQDPLGARRQPTTGGSKPWWWSYFTSLGQHQPRW LLKY >KAB0344502.1 hypothetical protein FD754_021428 [Muntiacus muntjak] MRPPPPLLLTMLVLAAARPGCEPAWGPEGGCPGSAASDSATCVDLQLQSCSDVAYNRTAFPTPLQHRSRAAVESSSEYVL LSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDPL EKLRGGLDIEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEV KLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDL NRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKM FSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPE EALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKV IKKVIIPARMKRAGRVDFILQPLRTGPQKFLLGSRRGWPGEEPQEPDQDPLGARRQPTTGGSKPWWWSYFTSLGQHQPRW LLKY >KAB0354429.1 hypothetical protein FD755_022967 [Muntiacus reevesi] MRPPPPLLLTMLVLAAARPGCEPAWGPEGGCPGSAGSDSATCVDLQLQSCSDVAYNRTAFPTPLQHRSRAAVESSSEYVL LSVLHHLLEGQCNPDLRLLGCAVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDPL EKLRGGLDIEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEV KLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDL NRNFPDLTSEYYRLASVRGARSDHIAIPQHYWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKM FSPTPDEKMFKLLARAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPE EALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKV IKKVIIPARMKRAGRVDFILQPLRTGPQKFLPGSRRGWPGEEPQEPDQDPLGARRQPTTGGSKPWWWSYFTSLGQHQPRW LLKY >KAF4013199.1 hypothetical protein G4228_004643 [Cervus hanglu yarkandensis] MTPPSPLPPATCVDLQLQSCSDVAYNRTAFPTLLQHRSRAAVESSPEYVLLSVLHHLLEGQCNPDLRLLGCAVLAPRCEG GRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDPLEKLRGGLDIEEALPSSYPHTFIQFTHHSYA QMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLL GNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQH YWWGKVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSEN RCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVM DKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIPSRMKRAGRVDFILQPLRTGPQKF LPGSRRGWPGEEPQEPDQDPLGARRQPTTGGSKPWWWSYFTSLGQHQPRWLLKY >XP_041443673.1 carboxypeptidase Z isoform X1 [Xenopus laevis] MSNCRTLTLLLGALLAARHAHCSPNCPPGDRALGRCMPTAEERGTCVDNILGYCNDLPYSKTMFPNALDQQSRGEIEYSA EYILLSVIDNLLQGECNPDLRIVGCAVLAPRCEKNKMVKPCRRVCEMLKKNCLPAFDAIDMAWPYFLDCDRFFVGEEEGC HDPLEKLRVNIDITPEDLLPENPSTFIQFIHHSYSEMVRVLKKTAAKCSQISKTYSIGRSYEGKDLLVIEFSANPGQHEV LTPEFRYIGNMHGNEVVGRELLIYLAQFLCSEYLLGNSRIQTLINTTRIHLLPSMNPDGYEHAAEMGAGYNGWTNGRQNA QNIDLNRNFPDLTSEAHKLIRMPLARLDHMPIPESYWDGKIAPETKAVMKWMRSIPFVISGSLHGGDLVISYPYDFSRHP LEEKMLSPTPDEKVFQLLAKTYVAAHPMMSDKSTSRCGGNFNSKGGIINGAEWYSFSGGMADFSYLHTNCFELTLELGCE KFPTEDELYSIWQNNKEAMLGLIEMVHRGIKGIVKDEYGNPIKKARISVRGIRHDIITGEDGDYFRLLIPGSHIVSAEAF GYSRVTKKITLPAKMLKAGRVDFVLQRVDVRNRKFPKVIPEDIYERFDPLDRFDPHAQHGGAEPSEGDEVSSRNGEKPWW WSYFSMLGHNRPSWLLKKNENKM >XP_020956608.1 carboxypeptidase Z [Sus scrofa] MPPPPLLLLLAALVLAAARPGCEPAWDPAGGCPRLAAVDSATCVDLQLRTCSDAAYNQTAFPTLLEHRSR EVVESSSEYVLLSVLHHLLEGQCNPDLRLLGCAVLAPRCQGGQVRRPCRHVCEGLREACQPAFDAIDMAW PYFLDCGRYFASQQEGCYDPLEKLRGGLDEEEALPSGHPATFIHFTHHSYAQMVRVLKRTAARCAHIAKT YSIGRSFDGRELLVLELSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNDRIQRLL NTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRTASARGARSDHIAIPQ HYWWGKVAPETKAIMKWMRAVPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYAD VHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTLWQH NKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSK VIKKVTIPARMKRAGRVDFILQPLGTGPKNFLLGPRRNGPGGAGPHGEPEEPGQEPLGARRLPEASGSKP WWWSYFRSLGQHQPRWLLKY >XP_030290269.1 carboxypeptidase Z-like isoform X1 [Sparus aurata] MHSGLWVLLLYLCGSSWCAPQQTCHPGDELLGRCSNNDFEEKPKCTELNLGYCNDMEYSRTMFPNILGHR NRMEAESGPEYLLLSVIHALLNGECTPEIRLVGCSVLASPCQNDKMIRPCRSTCEALRKDCGHSFEAIEM AWPYFLDCDRFFASDQEGCFDPLAGLKARQEIALSSLSPEEPSTIIQFTYTSNAQMYSLLKRTAAKCSHI SQVYSIGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLGRQLLIYLAQYLCSEYILGNQRIQ TLINTTRIHLLASMNPDGYELAAAEVEDSSDPELSNQEGHLFNGWISGRANAQNIDLNRNFPDLTSLFYR NRRSRHYRIDHIPIPDAYWFGKVAPETYAVMKWIRALPFVQSASLHGGELVISYPFDFSRDVHEEKMFSP TPDEQAFKQLARTYADAHATMSNNDTDRCGASFYRTRGIINGALWYSFAGGMSDFNYLHTNCLEITVELG CDKFPSEAELYPEWKRNKEALLSFMESVHRGIKGVVKDTDGNGIKGATISIRGIRKDVTTAEDGDYWRLL NPGTHIMTATAKGFSRVSKRVHLPHTMNKAGRVDFVLEKVPVEPDIDDHLFPTVDTWDRFDPYNQFERYS EPVVGEGGIEREEKPWWWNYFSQSGISPPNWLLRNV >XP_040191293.1 carboxypeptidase Z [Rana temporaria] MAGYYNHLLTGCLLTFTAGLVYASPRCLPGDRALGRCVDPASEKGTCTDNVLGYCDDLPYSKTMYPNSLD HRSRGDTEFSAEYILLSVIDNLLQGECNPDLRLLGCTVLAPRCEKNKIVKPCRKICETLKKNCLPAFDAI DMAWPYFLDCDRFFASDEEGCHDPLEKLRVNIEETPDDSLPQMPNTFIDFSHHSYAQMVSILKKTAGKCS HIAKTYNIGRSFEGKDLIVIEFSTKPGQHEPLKPEFRYIGNMHGNEVVGRELLIYLAQYLCSEYLLGNPR IQELINTTRIHLFPSMNPDGYELASEEGAGYNGWTNGRMTAQNIDLNRNFPDMTSEVHKIMKVRSARVDH LPIPETYSWDRVAPETKAVMKWMRNIPFVLSGSLHGGDLVVSYPYDFSKHPLEEKMFSPTPDEKVFTMLA KTYVASHPKMSDQATERCGGNFVRKGGIINGAEWYSFSGGMSDFSYLHTNCFELTLELGCEKFPTVDELY TAWKDNKESLLSFIEMVHRGIKGVVKDEHGNAIKNARISVKGIRHDIMTAEDGDYWRLLIPGVYIVSAEA FGYSKVTKKITLPAKLTKAGQVDFALKRVEVSNRRYNKVIPQDIYDRLDPLDSYDPHARRGQEGEDDQQS QDREKPWWWSYFSILGHNRPMWLLKNN >XP_039260303.1 carboxypeptidase Z-like [Styela clava] MQVVYILLLLNFILCFCTGDNTHEKSAESEKEKFKNSGECQWVSLPICQQVARSWANFPNLLGHRNQIEIANSSAYKYLE NLTRRMYASKSIGNSLDAGIDHQTELLERCTLQIYQVSCAFLVPKCVYVDRIQVSSLPPCKSTCMEVRERCESILHSEEM EWPEFLDCESWVQCHLPTVCRHSDAVLAPHSRSGTVQLPIQLVTRRRKIPRVEFKHHSELAARKVMTRLTRQCPGIMRLY TIGRSVKNKPLYVMEISDNAGMHEALEPEVKYIGAIHGNEVLGRELLLQLMQHICREWLLGNERIRNIVRNTRIHLLPTM NPDGYSVAARQGPERNGWLTGRFNSRDHDLNRHFPDLTKIAYINEAKFARNHHLEIPKRYWREHKKGSFPEIYAVIKWLE NYDFTLSAQLHGGELVANYPYDVRRKTSSYALKNFSPELMYSKSPDDKVFRHLASTYAENHGTMADPVLNRCEEKFGRRG GITNGAAWYTISGGMQDFNYLYTNSFEILIELSCRKFLPAKELPREWINNKEALLKYIEQAHIGIKGYVTDEFGIPFHRA VIHVHGIRHDVTTNEKGEYWRMLLPGKYIVTAVKDELTDTKWVHVTNNDTTASRYDFVLKQLPGRQRPNKQDIDELDIHE TEHQNQTTDKNVVQANFDEEPAKIAEPKSSINKNSFSEVRTTDQAQTTTFDFSTSTVPSIFTTGIEEEVSTQMTEINETV VDAGIRIMTNLVENILSIATGVRNTTIINDTNTTSQGVNTSSFEIDVTTESPNATYFGSGDGDETMIDKTNALEDTTAKI RHVKESNMQTNVIIYEITFDQSNSEDSDTDIMSSMTSDLNFSNATAIAQNSSFDSIQFDGSGDEENATYIESHSMKTNTT SENVHNGKAELHEGAKLSIFKEESSTSLDSANVPKISTKTHQKSEQEASKLAEVHVEAKWSTIKEESSISHDSANVPKIS TKTHQKSEQETSISLSGKTLNKEKFTSNRKLNNER >XP_038063978.1 carboxypeptidase E-like [Patiria miniata] MHLVTSFVSQIVALMLLSLNLGFPGSVAGQNGADHGIDFSYQSHNELVVLLHQIAWKCRSITRLYDIGRSVQGRRLYVLE MSDNPGVHEVGEAEFKYVANMHGNEATGRQLLIFLAQYLCEEYTKKNKRIQKLINSTRIHLLPTMNPDGFEMAYRRHVVM GRVPSMYGRGNANNVDLNRDFPDLNDIMYKHEQTGGANNHLLQLIRENKEGRQPETQAIMDWMAQYPFVLSANMHDGDLV ANYPYDKSRNTRKMYSATPDDNLFRELALTYSLYHRTMATRAEPCRFQGAKVFRDGVTNGADWYIVSGGMQDYNYLSSNC FDITLELGCDKFPREEELKRKWEDNRESLIEYIDKVHIGIKGQVMDTDRNPIANAVIRVTGPSIAHDVTTATDGDYWRLL LPGVYTVTVHARGYKPKTVVVPVRRYRPTKANFILKPLPKESSGCKLRQLEEEGYLLGGFRAALRQFGFLGDDCDGLVER REDVLASMEDTTASP >XP_030835262.1 carboxypeptidase D [Strongylocentrotus purpuratus] MTLLLALLAVLPFFSSVLGEPITATSEFPGSDYQWEHHDQEALYQILRDTNEECPEITRIYSAGESVEEEDLWVIEISDN PGKHEVGEPEFKYIGNMHGNEVVGREMLLLLIPYLCKNYETDPDIKWLVDNTRIHIMPTMNPDGYAAALEQLEERGENAW STGRANAHEVDLNRNFPDLDRIIFGRRADRFPRRHGLNNHITSHVDPRQLEPETRAIMSWLQEYPFILSANLHGGDIVAN YPYDSSHDGKANYEASPDDQVFRQVSLAYATPHPVMSDPNREQCDIGGEDAFKKGITNGADWYPLKGGMQDYNYLHTNCF EITIELSCKKFPSNPNDYEEFWGDNKQSLLDYIRQAHSGIKGTVTDENGVGIDDAKIKVWELTGPASEEHYIDHDITTAD DGDFWRLLVPGTYKVEAEACGFHAVNKTCTVAEPGTNVEASDCSFQLEEDNSTEGCSIEELESFLMNRLYPTY >XP_031559839.1 carboxypeptidase D-like [Actinia tenebrosa] MRCLKVLALVLCVHALTTFAKPPASLSKKSSAKVVKKSPTKSPIQHLAPVKPELKAKVRAVKQKVTAVKQQKHVVHEQKA AKEIPTKVVPKIKVEEIHEKNSSFRHHNYEEMTWLLKEFARKHQDIARLYDIGKSVQNRKLWVMEISDNPGKHEAEEPEV KYVANIHGNEVIGKEMLLHLIRYLCHNYGINKRVTNIVDATRIHILPSMNPDGYEMAATDDDHQAGSKNANDIDLNRNFP DQFFPSTTGPPQPETHAVMKWVRSNPFVLSASLHAGALVASYPYDDNPSGKTSYSASPDDDVFREVARAYSQAHPTMHLA NAPWKCKNKQKEHFIDGITNGADWFSLSGGMQDYNYVHSNCFEVTLELGCEKFPNATALPEYWRENKEALLSFVEQANKG IHGIIQDEDDKPIKDARINIANRPHDVFTSNKGDYWRLLVPGSYEVTVSAKGYEHESKTATVHSSAATKLDFTLRRIRER KPRHIEDNEDPRGSFTLRRSLRDFYRDESPDQKKQNYDGDDDNDYGARRQVLD >CAE1309007.1 CPE [Sepia pharaonis] MLLTSFPSSVEAAVSTSFSSNADFIHHNYSAMVDLLNEVNSKCPRITQVYNPPGHSVQNRNLTVIEFSDNPGHHTPGKPE FKYVANMHGNEVVGRELLLHLAVYLCQEYNANNHKIQWLINNTRIHLMPSMNPDGWELANTNHRKPDGTKDWLIGRRNAN NVDLNRNFPDLNNIMYENEISHGPNNHLEKLKYALNTPDLEAETKTVMKWLSAYPFVLSANLHGGDLVANYPYDLTRSGK QKEYSISPDDATFRYLAEAYSQNHRYMSKNHKSCGMANDQNFGVQDGITNGGEWYSVSRGMQDYNYLETNCFEITLELGC NKFPKASELSRYWKDNKDALIAYMLQTHIGLKGFVKSSWLQLPIQDAVIQVINMTDNKYINHDITTGRHGDYYRLLIDGY YQIRVIARGYHSQVRCHKVHNKMFHEAEILDFVMIPQHQRNKRDVKERLYCKMLQELADNQGHKLATEQEIFDEMMKDVS EYFNQ >NP_501935.1 Carboxypeptidase E [Caenorhabditis elegans] MLHAMRPVLLVAALLAVTAHAFLGFGSGSTHKDDAEWGHYHNQAQLEAKLGEINEKCPEITTLYEIGQSVEGRPLVVIQF STTPGEHIPTKPEVKLIGNMHGNEPIGRELLLRFAETLCNGAINNDKEIVQLLNSTSIHILPSMNPDGFELALGTEPAQR QWLTGRSNINGVDLNRDFPDLDSIFYELQKIGVPKFDHLLSLFEDNVDRQPETIAVGQWTLSLPFVLSANFHEGDLVANY PFDAAIDENSQKTAYSASPDDGTFRWLAKSYADNHAHMSKNDHAPCDGTSQDAFARQGGITNGAKWYSVAGGMQDFNYLA TNAMEITLELSCEKMPEGSQLPRFWEDNQKSIFEYVWKSHSGVKGMVVDAMTGEPIKRAVVWIRNGTETVPVKHPVTTWS EGDFYRVLPAGKYEIIVAAEGYDIAAKNVTVENKVRDSALVVNFALSPAADEPSENEQEQIAELVNEIARRR >XP_026296936.1 carboxypeptidase D isoform X2 [Apis mellifera] MAHISIIYTVPFMILFVGIIYGFAINSENKLEENFIIPHYTHYEELQQLFNSLVQKYPNLAKVFSIGKSVEGRNLLVLEI SENVKERKLCEPMVKYVANMHGDEAVGRELLVYLAQYLLHNYGKDERITKLINNTDIYLMPSMNPDGFEKSEEGKCESKK DFSGRENANHVDLNRNFPDQFDRRTNHLQKGGNILDGRQNETVAMMTWIATEPFVLSGNLHGGAVVASYPYDSGLTSCCT ESKSPDDELFKYLAHTYADNHPQMRTGRACESDVFQGGVINGAYWYEVIGGMQDFNYARSNAFEITFELSCCKYPNASEM PEYWKLNKESLITYFEQAHIGIKGLVRDIDGQPIEGATIIVRGINHNVSSTNHGEYWRLLLPGTYYIHAEAWGYRPSEPI NVIVKSGEPTIVNFTLKQDNYDQGELKSDKVEKIIKSIDKYGFLHNTEFKHHNYIAMEKYLKELNLNYPNITRLYSIGQS IKKRQLYVMEITENPGKHSKNKPEIKYIGNMHGNEVVGREILLLLLKYLCENFGNDKRVTKILKNVRLHVMPSMNPDGYE ISKEGDVDGIQGRTNAKGVDLNRNFPDQYETNNYNKKQETETKAVMNWIASIPFVLSANFHGGALVANYPYDNKPEYAAN GENPSPDDKVFKALALAYSNAHPRMHLGEPCPSFSNGRLNTESNLLEKSFPNGITNGAAWYSVNGGMQDYNYIHSNDFEI TIEVGCTKFPNVTELPNYWLQNREPLLRLIEMSRKGIHGVVRSSIGNPIPHAKISIEGIKHDIYAANDGDYWRLLVPGKY NVTVNAVGYESQMQTVTISNGVNFGEGEVTLDFTLMRDDPEHWSSAYDFRLMANLQNVYLKNAELSARFSQLESHQPNIT EFLAGESLINMDNIHSLKVTNNIGAPEENKFHIGLIGGLFASQPIGREILLRLATHILMGNQIGDPPIERILNNSVLHFI PGIDPTFDDIFNIQDCNPIVYDEVGKELLQKNINLNKLNKTTNAFKTMLLNEGYDVIIILGSGALEVSYTDDNLNVYENL AKNYEHSLRKGTCNFLNNDIKEVQNYIKNQYNIPVISINMDCCKYPRPGSIPIIWRENLLPLKKLIHGLTTGIRAIVTDI NDVPLRKAIVKIGTNNYHVSKNMAYFKIIVLPGEYMLIFFCEGYIEQTIKIHVNYESITNLYIKLIKHHIGKIEHQKYNE DQETNIVNQVLIDLNNKYSQLSILHTIGKSQIGTQIMCLEIGTENNKQIGRPSIAFIAGISNGAAVTSKILLYFAKYLLD HYQKDIRITNYLNQFTIYIAPDLSQNSNDNQTCTSSIMNNLQFPINNELTTDASMIINWFKNINAVLAINLNIGSQHIEI PFAGKYGKIHEQIYNTDDDDILQDLALLYTKYNIHMTSKDSQCNNNLNINYNGIIRGGIGISGKREHSLMDYLYLNTSTL MLNIYVTCCNTDDSKSVWEDNKASLLAMIEKLNEGVKGYVLDENNHPIENAILSYNQSIHHIKSSIHGAYWLLFQPGTHV ISATASKYIQQTKVFITPDIHNISYLIFKLKYDDNYLGMPRIVFIILLSTLCLGIVICSIFICISCQSSKNLEKNNWRQY SFSLLKDGTSFFDDDEKEIEIFKRPLNGHTQIKEITKPYFDDDNMSSSEDASDLEFVRPSKEWEEEPTKQHR
Mafft alignment of selected proteins >sp|Q66K79|CBPZ_HUMAN Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ PE=1 SV=2 -------------MPPP--------LPLLLLT---------------------------- ------------------------------VL--VVA---AARPGCEF---------ERN PAGECHR------------------------------------PPAADSATC---VDLQL RTCSDAAYNHTTFPNLLQHRSW------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYILWQHNKESLLNFVETVHRGIKGVVT DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVII--PARM-KRAGRV--DFILQPLGMGPKNFIHG-----------LRR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >sp|Q66K79-2|CBPZ_HUMAN Isoform 2 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ -------------MPPP--------LPLLLLT---------------------------- ------------------------------VL--VVA---AARPGCEF---------ERN PA-----------------------------------------------ATC---VDLQL RTCSDAAYNHTTFPNLLQHRSW------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYILWQHNKESLLNFVETVHRGIKGVVT DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVII--PARM-KRAGRV--DFILQPLGMGPKNFIHG-----------LRR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >sp|Q66K79-3|CBPZ_HUMAN Isoform 3 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYILWQHNKESLLNFVETVHRGIKGVVT DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVII--PARM-KRAGRV--DFILQPLGMGPKNFIHG-----------LRR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >tr|F6P711|F6P711_DANRE Carboxypeptidase Z OS=Danio rerio OX=7955 GN=cpz PE=3 SV=1 -------------MDNKML-----TLL-ILLN---------------------------- ------------------------------AL--ATC--LSFPQRCTQ---------EEA AIGRCR-------------------------------------TPAEEGPQC---IEMVL GYCQDVPYTHTTFPNIVGHRTR------------------QDLEMGAEYLLL-------- -------------------SVIHGL---------MKGECSPDIRI--------------- ---------------------------LGCS----------------------VLAPRCE NGRLMK-----PCRSSCEMLKKSCIHAFEAIQMAWPYFLDCDRFFVGSEEGCYD-PLSE- ---------------LREKQEVA-----------LANISDGGLSTVIQFTY-HSNSQMFS ILKKTASKCSHISQTYS-IGRSVEGKDLLVIEFSNNPGQHDLLEPEIKLIGNMHGNEVLG RQLLIYLAQYLCSEYLLGNERIQTIINTTRIHILASMNPDGYEIAAS------------- EGHEYNGWTSGRANAQNLDLNRNFPDLTSIFYNRRRFRHFRSDHI--PIPDSYW--MNKV VAPETYAIMKWIRTYPFVISASLHGGELVISYPFDFSRHPQ--------EDRMYSPTPDE QIFRQLARTYADAHATMSNND-TERC---------------GASFANKGGITNGALWYSF AGGMSDFNYLHSNCYEITVELGCDKFPSE-EELYPEWRRNKEALLSFMESVHKGIKGIVK DE-HGNGIKGAIISVKG----------LRHDITTAEDGDYWRLMNPGVHIVTASASGYSK QSKRINL--PRN--TQVGRV--DFVLKKVPREPSLDYFN-----------IPELDNYERF ------------------------------------------------------------ ---------------DPF------------------------------------------ -------------NQF--------------------------------EQYSQRELG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------EDGEERTEKPW------------------ ------------------------------------------------------------ ---------------------------------------WWGY----------------- -----------------------------------------------------------F SQLGMSAPTWLLRNY--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_038948430.1 carboxypeptidase Z isoform X1 [Rattus norvegicus] MHRSKSCYRKSFRVCSA--------PG-VLTS---------------------------- ------------------------------------------DQGCLTD---THFLTETG HTGKCQR------------------------------------LASTHSATC---VDLHL RTCADAAYNHTSFPTPLEHRSW------------------EAVEASPEYTLL-------- -------------------GVLHFL---------LEGQCNPDLRL--------------- ---------------------------LGCS----------------------VLAPRCQ GGHTQR-----PCRRVCEGLREACQPAFDAIDMAWPYFLDCTQYFAPEEEGCYD-PLEQ- ---------------LRGEL-DV-----------EEALPSGLPPTFIRFAH-HSYAQMVR VLKRTAARCSQVAKTYS-IGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REILIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHI--PISQYYW--WGK- VAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKHPH--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYGLWQHNKEPLLNFLEMVHRGIKGVVT DK-YGKPVKNARILVKG----------IRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSK VMKRVTI--PLRM-KRAGRV--DFILQPLGTGPKNFLPG-----------PSR-ALPRSL ------------------------------------------------------------ ---------------DPQ------------------------------------------ --------GAPAQLDF--------------------------------EPPRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ASGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWAY----------------- -----------------------------------------------------------F TSLSPHKPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >NP_694747.2 carboxypeptidase Z precursor [Mus musculus] -------------MPTM--------PL-LLAAL--------------------------- --------------------------AALAVL--ALA--ARPSPSCSP---------GPD PSGKCQR------------------------------------LVYTHSATC---VDLHL RTCADAAYNHTSFPTPLEHRSW------------------EAVESSPEYMLL-------- -------------------GVIHFL---------LEGQCNPDLRL--------------- ---------------------------LGCS----------------------VLAPRCE GGHTQR-----PCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEEGCYD-PLEE- ---------------LRGEL-DV-----------EEALPSGLPPTFIRFAH-HSYAQMVR VLKRTAARCSQVAKTYS-IGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REVLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHI--PISQYYW--WGK- VAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPH--------EKKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYGLWQQNKEPLLNFLEMVHRGIKGMVT DK-YGKPVKNARILVKG----------IRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSK VMKRVTI--PLRM-KKAGRV--DFILHPLATGPKNFLPG-----------PSR-ALPRFQ ------------------------------------------------------------ ---------------DPQ------------------------------------------ --------REPTQMDF--------------------------------EPPRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------ASGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWAY----------------- -----------------------------------------------------------F TSLSPYKPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >NP_989909.3 carboxypeptidase Z precursor [Gallus gallus] -------------MVPS--------LL-LLLT---------------------------- ------------------------------GL--FRA--TEPAPRCET---------GQE TLGQCQ---------------------------------------AAQKAKC---VDISL SSCTDVTYTQTMYPNFLDQKSR------------------EVIEYSSEYILI-------- -------------------SVLHNL---------LQGECNPDLRL--------------- ---------------------------LGCS----------------------VLAPQCE KDKVIK-----PCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFD-PLAK- ---------------LRGEV-AV-----------EEDLPSDFPATFIQFKH-HSYSQMVS TLKKTASRCSHIATTYS-IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVG KELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAE------------- EGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHI--PIPQSYW--WGK- VAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPM--------EEKEFSPTPDE KMFKMLAKAYADAHPVISDRS-EHRC---------------GGNFVKRGGIINGAEWYSF TGGMADFNYLHTNCFEVTVEVGCEKFPLE-EELFTIWHENRDALLNYMEMVHRGIKGIVS DK-FGNPIKNARISVRG----------IQHDITTAADGDYWRLLPPGTYIVTAQAMGYTK VMKRVTL--PIKM-KRAGRV--DFVLRPIEIWPNKLLRR-----------PME-DMYDQY ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------ELF--------------------------------DPHTQHAQA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------RGGSQQVREKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SSLDLHKPLWLLKQH--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >NP_001289340.1 carboxypeptidase Z precursor [Pan troglodytes] -------------MPPP--------PPLLLLT---------------------------- ------------------------------VL--VVA---AARPGCEF---------ERN PAGECHR------------------------------------PPAADSATC---MDLQL RTCSDAAYNHTTFPNLLQHRSW------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTGGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYTLWQHNKESLLNFVETVHRGIKGVVT DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVII--PTRM-KRAGRV--DFILQPLGLESKNFFHG-----------LRR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_038322250.1 carboxypeptidase Z isoform X1 [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------MQL RTCSDVAYNWTTFPTLLEQRSR------------------EAVESSSEYILL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASVEEGCYD-PLEK- ---------------LREGL-DA-----------EEALPSGLPPTFIHFTH-HSYAQMVR VLRRTAARCAHVAKTYS-IGRSFNGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASSRSVRSDHI--PIPQHYW--WGK- VAPETKAIMKWMRTTPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTLWQHNKEPLLNFVEMVHRGIKGVVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGPHIVIAQAPGYSK VIKKVTI--PARM-KRAGRV--DFILQPLGTGPKKVLLG-----------PRR-SGSGLR ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASPYGEPEEVGQ--------------------------------EPLGGRRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SSGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSQHKPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >NP_001076955.1 carboxypeptidase Z precursor [Bos taurus] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLA---AARPGCEP---------AWD PEGGCPR------------------------------------SAAADSAMC---VDLQL QTCSDVTYNRTAFPTLLQHRSR------------------EAVESSSEYILL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYD-PLEK- ---------------LRGGL-DI-----------EEALPSGHPPTFIQFTH-HSYAQMVR VLRRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLFYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSNHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDD KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCMKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PARM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GGLG-- ------------------------------------------------------------ ------------------------------------------------------------ --------GEPQEPDE--------------------------------EPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_024102119.1 carboxypeptidase Z isoform X1 [Pongo abelii] -------------MPPP--------PPLLLLT---------------------------- ------------------------------VL--VVA---AARPGCEF---------ERN PAGECHR------------------------------------PPAADSATC---VDLQL RTCSDAAYNHTTFPNLLQHRSR------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREACQPAFDAIDMAWPYFLNCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYTLWQHNKESLLNFVEMVHRGIKGVVT DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGVHIVIAQAPGYAK VIKKVII--PTRM-KRAGRV--DFILQPLGMGPKNFLHG-----------LQR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_010708822.1 carboxypeptidase Z [Meleagris gallopavo] -------------MVPS--------LL-LLLT---------------------------- ------------------------------GL--FRA--TEPAPRCET---------GQE TLGQCQ---------------------------------------TAQKAKC---VDISL SSCTDVTYTQTMYPNFLDQKSR------------------EVIEYSSEYILI-------- -------------------SVLHNL---------LQGECNPDLRL--------------- ---------------------------LGCS----------------------VLAPQCE KDKVIK-----PCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFD-PLAK- ---------------LRGEV-VV-----------EEDLPSDLPATFIQFKH-HSYSQMVS TLKKTASRCSHIATTYS-IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVG KELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAE------------- EGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHI--PIPQSYW--WGK- VAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPM--------EEKEFSPTPDE KLRISGKLGFLLLSPAVR-------------------------------------EWIRP TS---------------------RSLP---------------------EPVPRS----CS SA-HESPREAPRL-------------------------EYFRGWAPG------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_034807806.1 carboxypeptidase Z isoform X1 [Pan paniscus] -------------MPPP--------PPLLLLT---------------------------- ------------------------------VL--VVV---AARPGCEF---------ERN PAGECHR------------------------------------PPAADSATC---MDLQL RTCSDAAYNHTTFPNLLQHRSW------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYTLWQHNKESLLNFVETVHRGIKGVVT DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAK VIKKVII--PTRM-KRAGRV--DFILQPLGLGSKNFLHG-----------LRR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_003985597.3 carboxypeptidase Z [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------MAWPYFLDCGSYFASVEEGCHD-PLEK- ---------------LRGGL-DA-----------EEALPSGPPPTFIHFTH-HSYAQMVR VLRRTAARCAHIAKTYS-IGRSFDGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEFYRLEASGSIRSSRI--PIPQHYW--WGK- VAPETKAIIKWMRTTPFVLSASLHGGDLVVSYPFDLSKHSQ--------EEK-FSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFVEMVHRGIKGVVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSK VIKKVTI--PARM-KRAGRV--DFILQPLGTGPKKFLLG-----------PRR-SGSAVR ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASPYGEPQEPGQ--------------------------------EPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SAGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSISQHKPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_027827070.1 carboxypeptidase Z [Ovis aries] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLA---AARPGCEP---------AWD PEGACSG------------------------------------PAAADSATC---VDLQL QTCSDVTYNRTAFPTLLQHRTR------------------AAVESSSEYILL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYD-PLEK- ---------------LRGGL-DV-----------EEALPSGYPPTFIQFTH-HSYAQMVR VLRRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHI--AIPQHYW--WGK- VAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PSRM-KRAGRV--DFILQPLRTGPHKFLPG-----------SRR-GGLG-- ------------------------------------------------------------ ------------------------------------------------------------ --------GEPQEPDQ--------------------------------EPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_030866357.1 carboxypeptidase Z [Gorilla gorilla gorilla] MPPP---------PPPP--------PPLLLLT---------------------------- ------------------------------VL--VVA---AARPGCEF---------ERK PAGECHR------------------------------------PPAADSATC---VDLQL RTCSDAAYNHTTFPNLLQHRSW------------------EVVEASSEYILL-------- -------------------SVLHQL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGWVRR-----PCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYD-PLEK- ---------------LRGGL-EA-----------DEALPSGLPPTFIRFSH-HSYAQMVR VLRRTASRCAHVARTYS-IGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHI--PIPQHYW--WGK- VAPETKAVMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLSRAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHTNCFEITVELGCVKFPPE-EALYTLWQHNKESLLNFMEMVHRGIKGVVT DK-FGKPLKNARISVKG----------IRHDITTAPDGDYWRLLPPGIHIVIVQAPGYAK VIKKVII--PTRM-KRAGRV--DFILQPLGMGPKNFLHG-----------LQR-TGPH-- ------------------------------------------------------------ ---------------DPL------------------------------------------ --GGASSLGEATEP----------------------------------DPLRARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------SADGNKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLSTHRPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_023816686.1 carboxypeptidase Z isoform X1 [Oryzias latipes] -------------MSPDVL----PPLL-LLLW---------------------------- ------------------------------TS--APC-WCAPQHTCHP---------GDE LLGRCST------------------------------------GARQDRAAC---TELNL GYCNDLDYSRTIFPNILGHQSR------------------VEAESGAEYLLL-------- -------------------SVIHGL---------LNGECSPEIRL--------------- ---------------------------VGCS----------------------VLASPCR DDKMIK-----PCRRTCEALRKDCSHAFEAIEMAWPYFLDCDRFFASDQEGCFD-PLAG- ---------------LKAKQELA-----------LSSLSPEEPSTIIQFTY-TSNSQMYS LLKRTAAKCAHISHVYS-IGRSTEGRDLLVIEFTNNPGQHELLEPEVKMVGNMHGNEVLG RQLLIYLAQYLCSEYNLGNQRIQSIINSTRIHILASMNPDGYELASSEVEDNSERDLNNQ EGHLLNGWTNGRSNAQNIDLNRNFPDLTSIFYRNRRSRHYRTDHI--PIPDGYW--FGK- VAPETYAVMKWIRSLPFVQSASLHGGELVVSYPFDFSRHPQ--------EERMFSPTPDE QAFKQMARTYADAHATMSNND-TDRC---------------GASFYWNRGIINGALWYSF AGGMSDFNYLHTNCMEITVELGCDKFPPE-AELYPEWKRNKEALLSFLESVHRGIKGEVK DT-DGNGIKGATVSVRG----------IRKDVTTAEDGDYWRLLNPGTYIVTATAKGYSK VSKRVHL--PHRM-NKAGRV--DFVLEKVPVEPGIEDHL-----------FPTVDSWERF ------------------------------------------------------------ ---------------DPY------------------------------------------ -------------NQF--------------------------------ERFSE---G--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------DGGVERQEKPW------------------ ------------------------------------------------------------ ---------------------------------------WWNY----------------- -----------------------------------------------------------F SQSGISPPTWLLRNV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_005498499.1 carboxypeptidase Z [Columba livia] -------------MVLR--------LL-LLLA---------------------------- ------------------------------GL--LRA--TKPAPRCET---------GQE TLGQCQ---------------------------------------SVQKAKC---VDITL SSCTDVAYTQTMYPNFLDQKTR------------------EVIEYSSEYILI-------- -------------------SVLHNL---------LQGECNPDLRL--------------- ---------------------------LGCS----------------------VLAPQCE KDKVIK-----PCRHVCENLKKNCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFD-PLAK- ---------------LRGEV-DV-----------EEDLPSDLPGTFIQFKH-HSYSQMVS TLKKTASKCSHIATTYS-IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVG KELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAE------------- EGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAEIRGARLDHI--PIPQSYW--WGK- VAPETKAVMKWLRSIPFVLSASLHGGELVVTYPYDYSRHPM--------EEKMFSPTPDE KMFKMLAKAYADAHPVISDRS-EHRC---------------GGNFVKRGGIINGAEWYSF TGGMADFNYLHTNCFEVTVEVGCEKFPLE-EELFTIWHENRDALLNYMEMVHRGIKGIVS DK-FGNPIKNARISVRG----------IQHDVTTAADGDYWRLLPPGTYIISAQASGYSR VIKRVTI--PAKM-KQAGRV--DFVLRPAEAWPNKLLRR-----------SME-DMYDPY ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------ELF--------------------------------DPHAQHRQA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EARGGSPPGREKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SSLGLHKPLWLLKQR--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_017905285.1 PREDICTED: carboxypeptidase Z [Capra hircus] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLA---AARPGCEP---------AWD PEGACSR------------------------------------SVAADSATC---VDLQL QTCSDVTYNRTAFPTLLQHRTR------------------AAVESSSEYILL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYD-PLEK- ---------------LRGGL-DI-----------EEALPSGYPPTFIQFTH-HSYAQMVR VLRRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHI--AIPQHYW--WGK- VAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFVEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHAITTAPDGDYWRLLPPGAHIVIAQAPGYSR VIKKVII--PSRM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GGLG-- ------------------------------------------------------------ ------------------------------------------------------------ --------GEPQEPDQ--------------------------------EPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_006017072.1 carboxypeptidase Z [Alligator sinensis] -------------MLLH--------IL-LFLG---------------------------- ------------------------------AL--AKV--TEPAPRCET---------GQE TLGQCQ---------------------------------------AEQKAKC---VDITV GTCNDVPYSKTMYPNLLDQKAR------------------QAVEYSSEYILI-------- -------------------SVIHNL---------LQGECNPDLRL--------------- ---------------------------LGCS----------------------ILAPQCE KDKIIK-----PCRHICEKLKKSCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFD-PLAK- ---------------LRGELEVA-----------EEDPLAGLPTTFIQFTH-HSYSQMVS ILKRTASKCSHIARTYS-IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVG KELLIYLAQYLCSEYLLGNPRIQMLINHTRIHLLPSLNPDGYDLAAE------------- EGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHI--PIPQSYW--WGK- VAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPL--------EEKMFSPTPDE KMFKLLAKAYADAHPIISDKS-EIRC---------------GGSFGKRGGIINGAEWYSF PGGMADFNYLHTNCFEITVEVGCEKFPLE-EELYSIWHENRESLLNFIEMVHRGIKGIVS DK-LGNPIKNARISVRG----------IRHDVTTADDGDYWRLLPPGTYIISAHAVGYSK VIKKVTL--PVKM-KRAGRV--DFVLRPSEFWPNKFLRR-----------PME-AMRDQY ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------EHF--------------------------------DPHAQHAQPGQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RNERGDLTRNRERPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SSLDQHKPMWLLKRN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_006264271.1 PREDICTED: carboxypeptidase Z [Alligator mississippiensis] -------------MLLH--------IL-LFLG---------------------------- ------------------------------AL--AKV--TEPAPRCET---------GQE TLGQCQ---------------------------------------TEQKAKC---VDITV GTCNDVPYSKTMYPNLLDQKAR------------------QAVEYSSEYVLI-------- -------------------SVIHNL---------LQGECNPDLRL--------------- ---------------------------LGCS----------------------ILAPQCE KDKIIK-----PCRHICEKLKKSCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFD-PLAK- ---------------LRGELEVA-----------EEDPLAGLPTTFIQFTH-HSYSQMVS ILKRTASKCSHIARTYS-IGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVG KELLIYLAQYLCSEYLLGNPRIQMLINHTRIHLLPSLNPDGYDLAAE------------- EGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHI--PIPQSYW--WGK- VAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPL--------EEKMFSPTPDE KMFKLLAKAYADAHPIISDKS-EIRC---------------GGSFGKRGGIINGAEWYSF PGGMADFNYLHTNCFEITVEVGCEKFPLE-EELYSIWHENRESLLNFIEMVHRGIKGIVS DK-LGNPIKNARISVRG----------IRHDITTADDGDYWRLLPPGTYIISAHAVGYSK VIKKVTL--PVKM-KRAGRV--DFVLRPSEFWPNKFLRR-----------PME-AMRDQY ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------EHF--------------------------------DPHAQHAQPGQ- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------RNERGDLTRNKERPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SSLGQHKPMWLLKRN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_015827050.1 PREDICTED: carboxypeptidase Z-like isoform X1 [Nothobranchius furzeri] -------------MRLE--------LL-ALSL---------------------------- ------------------------------LL--TGC-CCVPQRRCHP---------GDE FLGMCS-------------------------------------SAQEVTPTC---TEMNL GYCNDVEYTRTIFPNILGHRSR------------------LEVESGAEYLLL-------- -------------------SVIHAL---------LNGECSPEIRL--------------- ---------------------------VGCS----------------------VLASPCR DNKMIK-----PCRSTCEALRKDCRHAFDAIEMAWPYFLDCDRFFASEEEGCFD-PLAG- ---------------LKARQELA-----------LSSLSPEEPSTIIQFTY-TSNAQMYS LLKRTAAKCSHISHVYS-IGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLG RQLLIYLAQYLCSEYILGNQRIQTIINTTRIHILASMNPDGYELAASEVEDSNDPELSNQ EGHLLNGWTNGRTNAQNLDLNRNFPDLTSIFYRNRRSRHYRSDHI--PIPDSYW--FSK- VAPETYAVMKWIRSLPFVQSASLHGGELVISYPFDFSKHPH--------EEKMFSPTPDE QVFKQLARTYADAHATMSNND-TDRC---------------GASFYRNRGIINGALWYSF AGGMSDFNYLHTNCMEITVELGCDKFPSE-AELYPEWKRNKEALLSFLESVHRGIKGVVK DL-DGNGIKGATVSVRG----------IRRDVTTAEDGDYWRLLNPGTHILTATAKGFSK VSKRVYL--PHNM-NKAGLV--DFVLEKVPVEPDINDHL-----------FPTTDTWDRF ------------------------------------------------------------ ---------------DPY------------------------------------------ -------------NQF--------------------------------ERYSSPDVA--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------EGDVEREEKPW------------------ ------------------------------------------------------------ ---------------------------------------WWNY----------------- -----------------------------------------------------------F SQSGISPPNWLLRNV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_020745074.1 carboxypeptidase Z [Odocoileus virginianus texanus] -------------MWES--------GE-NWIS---------------------------- ------------------------------CR--KLE--SSPVDVFTP------RRLASS PSG-CPS------------------------------------SAAADSAMC---VDLQL QSCSDVAYNRTAFPTLLQHRSH-------------------------------------- ---------------------VGYW---------LERQ--PDVSE--------------- ---------------------------------------------------------RGP GNR--------------------------------------------------------- ------------------GL-DI-----------EEALPSSHPHTFIQFTH-HSYAQMVR VLKRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KLPPP-----------------------------------------------------HW AAGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PARM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GWPG-- ------------------------------------------------------------ ------------------------------------------------------------ --------GEPQEPDQ--------------------------------DPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_043304186.1 carboxypeptidase Z [Cervus canadensis] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLT---AARPGCEP---------AWG PEGGCPG------------------------------------SAAADSATC---VDLQL QSCSDVAYNRTAFPTLLQHRSR------------------AAVESSPEYVLL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYD-PLEK- ---------------LRGGL-DI-----------EEALPSSYPHTFIQFTH-HSYAQMVR VLKRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PSRM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GWPG-- ------------------------------------------------------------ ------------------------------------------------------------ --------EEPQEPDQ--------------------------------DPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >KAB0344502.1 hypothetical protein FD754_021428 [Muntiacus muntjak] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLA---AARPGCEP---------AWG PEGGCPG------------------------------------SAASDSATC---VDLQL QSCSDVAYNRTAFPTPLQHRSR------------------AAVESSSEYVLL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYD-PLEK- ---------------LRGGL-DI-----------EEALPSSHPHTFIQFTH-HSYAQMVR VLKRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PARM-KRAGRV--DFILQPLRTGPQKFLLG-----------SRR-GWPG-- ------------------------------------------------------------ ------------------------------------------------------------ --------EEPQEPDQ--------------------------------DPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >KAB0354429.1 hypothetical protein FD755_022967 [Muntiacus reevesi] -------------MRPP--------PP-LLLT---------------------------- ------------------------------ML--VLA---AARPGCEP---------AWG PEGGCPG------------------------------------SAGSDSATC---VDLQL QSCSDVAYNRTAFPTPLQHRSR------------------AAVESSSEYVLL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYD-PLEK- ---------------LRGGL-DI-----------EEALPSSHPHTFIQFTH-HSYAQMVR VLKRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PARM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GWPG-- ------------------------------------------------------------ ------------------------------------------------------------ --------EEPQEPDQ--------------------------------DPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >KAF4013199.1 hypothetical protein G4228_004643 [Cervus hanglu yarkandensis] -------------MTPP--------SP-L------------------------------- ------------------------------------------------------------ -----------------------------------------------PPATC---VDLQL QSCSDVAYNRTAFPTLLQHRSR------------------AAVESSPEYVLL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCE GGRVRR-----PCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYD-PLEK- ---------------LRGGL-DI-----------EEALPSSYPHTFIQFTH-HSYAQMVR VLKRTAARCAHISKTYS-IGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAG REMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTIWQHNKEPLLNFMEMVHRGIKGMVM DK-FGKPVKNARILVKG----------IRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSK VIKKVII--PSRM-KRAGRV--DFILQPLRTGPQKFLPG-----------SRR-GWPG-- ------------------------------------------------------------ ------------------------------------------------------------ --------EEPQEPDQ--------------------------------DPLGARRQP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------TTGGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F TSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_041443673.1 carboxypeptidase Z isoform X1 [Xenopus laevis] -------------MSNCRT------LT-LLLG---------------------------- ------------------------------AL--LAARHAHCSPNCPP---------GDR ALGRCM-------------------------------------PTAEERGTC---VDNIL GYCNDLPYSKTMFPNALDQQSR------------------GEIEYSAEYILL-------- -------------------SVIDNL---------LQGECNPDLRI--------------- ---------------------------VGCA----------------------VLAPRCE KNKMVK-----PCRRVCEMLKKNCLPAFDAIDMAWPYFLDCDRFFVGEEEGCHD-PLEK- ---------------LRVNIDIT-----------PEDLLPENPSTFIQFIH-HSYSEMVR VLKKTAAKCSQISKTYS-IGRSYEGKDLLVIEFSANPGQHEVLTPEFRYIGNMHGNEVVG RELLIYLAQFLCSEYLLGNSRIQTLINTTRIHLLPSMNPDGYEHAAE------------- MGAGYNGWTNGRQNAQNIDLNRNFPDLTSEAHKLIRMPLARLDHM--PIPESYW--DGK- IAPETKAVMKWMRSIPFVISGSLHGGDLVISYPYDFSRHPL--------EEKMLSPTPDE KVFQLLAKTYVAAHPMMSDKS-TSRC---------------GGNFNSKGGIINGAEWYSF SGGMADFSYLHTNCFELTLELGCEKFPTE-DELYSIWQNNKEAMLGLIEMVHRGIKGIVK DE-YGNPIKKARISVRG----------IRHDIITGEDGDYFRLLIPGSHIVSAEAFGYSR VTKKITL--PAKM-LKAGRV--DFVLQRVDVRNRKFPKV-----------IPE-DIYERF ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------DRF--------------------------------DPHAQHGGAEP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------SEGDEVSSRNGEKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SMLGHNRPSWLLKKNENKM----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_020956608.1 carboxypeptidase Z [Sus scrofa] -------------MPPP--------PLLLLLA---------------------------- ------------------------------AL--VLA---AARPGCEP---------AWD PAGGCPR------------------------------------LAAVDSATC---VDLQL RTCSDAAYNQTAFPTLLEHRSR------------------EVVESSSEYVLL-------- -------------------SVLHHL---------LEGQCNPDLRL--------------- ---------------------------LGCA----------------------VLAPRCQ GGQVRR-----PCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASQQEGCYD-PLEK- ---------------LRGGL-DE-----------EEALPSGHPATFIHFTH-HSYAQMVR VLKRTAARCAHIAKTYS-IGRSFDGRELLVLELSSRPGQHELMEPEVKLIGNIHGNEVAG REILIYLAQYLCSEYLLGNDRIQRLLNTTRIHLLPSMNPDGYEVAAA------------- EGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRTASARGARSDHI--AIPQHYW--WGK- VAPETKAIMKWMRAVPFVLSASLHGGDLVVSYPFDFSKHPQ--------EEKMFSPTPDE KMFKLLARAYADVHPMMMDRS-ENRC---------------GGNFLKRGSIINGADWYSF TGGMSDFNYLHSNCFEITVELGCVKFPPE-EALYTLWQHNKEPLLNFVEMVHRGIKGVVM DK-FGKPVKNARISVKG----------IRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSK VIKKVTI--PARM-KRAGRV--DFILQPLGTGPKNFLLG-----------PRR-NGPG-- ------------------------------------------------------------ ------------------------------------------------------------ ---GAGPHGEPEEPGQ--------------------------------EPLGARRLP--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------EASGSKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F RSLGQHQPRWLLKY---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_030290269.1 carboxypeptidase Z-like isoform X1 [Sparus aurata] -------------MHSGL-------WV-LLLY---------------------------- ------------------------------LC--GSS-WCAPQQTCHP---------GDE LLGRCSN------------------------------------NDFEEKPKC---TELNL GYCNDMEYSRTMFPNILGHRNR------------------MEAESGPEYLLL-------- -------------------SVIHAL---------LNGECTPEIRL--------------- ---------------------------VGCS----------------------VLASPCQ NDKMIR-----PCRSTCEALRKDCGHSFEAIEMAWPYFLDCDRFFASDQEGCFD-PLAG- ---------------LKARQEIA-----------LSSLSPEEPSTIIQFTY-TSNAQMYS LLKRTAAKCSHISQVYS-IGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLG RQLLIYLAQYLCSEYILGNQRIQTLINTTRIHLLASMNPDGYELAAAEVEDSSDPELSNQ EGHLFNGWISGRANAQNIDLNRNFPDLTSLFYRNRRSRHYRIDHI--PIPDAYW--FGK- VAPETYAVMKWIRALPFVQSASLHGGELVISYPFDFSRDVH--------EEKMFSPTPDE QAFKQLARTYADAHATMSNND-TDRC---------------GASFYRTRGIINGALWYSF AGGMSDFNYLHTNCLEITVELGCDKFPSE-AELYPEWKRNKEALLSFMESVHRGIKGVVK DT-DGNGIKGATISIRG----------IRKDVTTAEDGDYWRLLNPGTHIMTATAKGFSR VSKRVHL--PHTM-NKAGRV--DFVLEKVPVEPDIDDHL-----------FPTVDTWDRF ------------------------------------------------------------ ---------------DPY------------------------------------------ -------------NQF--------------------------------ERYSEPVVG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------EGGIEREEKPW------------------ ------------------------------------------------------------ ---------------------------------------WWNY----------------- -----------------------------------------------------------F SQSGISPPNWLLRNV--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_040191293.1 carboxypeptidase Z [Rana temporaria] -------------MAGYYN-----H---LLTG---------------------------- ------------------------------CLLTFTAGLVYASPRCLP---------GDR ALGRCV-------------------------------------DPASEKGTC---TDNVL GYCDDLPYSKTMYPNSLDHRSR------------------GDTEFSAEYILL-------- -------------------SVIDNL---------LQGECNPDLRL--------------- ---------------------------LGCT----------------------VLAPRCE KNKIVK-----PCRKICETLKKNCLPAFDAIDMAWPYFLDCDRFFASDEEGCHD-PLEK- ---------------LRVNIEET-----------PDDSLPQMPNTFIDFSH-HSYAQMVS ILKKTAGKCSHIAKTYN-IGRSFEGKDLIVIEFSTKPGQHEPLKPEFRYIGNMHGNEVVG RELLIYLAQYLCSEYLLGNPRIQELINTTRIHLFPSMNPDGYELASE------------- EGAGYNGWTNGRMTAQNIDLNRNFPDMTSEVHKIMKVRSARVDHL--PIPETYS--WDR- VAPETKAVMKWMRNIPFVLSGSLHGGDLVVSYPYDFSKHPL--------EEKMFSPTPDE KVFTMLAKTYVASHPKMSDQA-TERC---------------GGNFVRKGGIINGAEWYSF SGGMSDFSYLHTNCFELTLELGCEKFPTV-DELYTAWKDNKESLLSFIEMVHRGIKGVVK DE-HGNAIKNARISVKG----------IRHDIMTAEDGDYWRLLIPGVYIVSAEAFGYSK VTKKITL--PAKL-TKAGQV--DFALKRVEVSNRRYNKV-----------IPQ-DIYDRL ------------------------------------------------------------ ---------------DPL------------------------------------------ -------------DSY--------------------------------DPHARRGQE--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------GEDDQQSQDREKPW------------------ ------------------------------------------------------------ ---------------------------------------WWSY----------------- -----------------------------------------------------------F SILGHNRPMWLLKNN--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_039260303.1 carboxypeptidase Z-like [Styela clava] -------------MQVV-------YIL-LLLNF--------------------------- ------------------------------IL-------------CFCT--------GDN THEKSAE---------------------------------SEKEKFKNSGEC---QWVSL PICQQVARSWANFPNLLGHRNQ------------------IEIANSSAYKYL-------- --------ENLTRRMYASKSIGNSLDAGIDHQTELLERCTLQIYQ--------------- ---------------------------VSCA----------------------FLVPKCV YVDRIQVSSLPPCKSTCMEVRERCESILHSEEMEWPEFLDCESWVQ-----CHL-PTVC- ---------------RHSDAVLAPHSRSGTVQLPIQLVTRRRKIPRVEFKH-HSELAARK VMTRLTRQCPGIMRLYT-IGRSVKNKPLYVMEISDNAGMHEALEPEVKYIGAIHGNEVLG RELLLQLMQHICREWLLGNERIRNIVRNTRIHLLPTMNPDGYSVAAR------------- QGPERNGWLTGRFNSRDHDLNRHFPDLTKIAYINEA-KFARNHHL--EIPKRYWREHKKG SFPEIYAVIKWLENYDFTLSAQLHGGELVANYPYDVRRKTSSYALKNFSPELMYSKSPDD KVFRHLASTYAENHGTMADPV-LNRC---------------EEKFGRRGGITNGAAWYTI SGGMQDFNYLYTNSFEILIELSCRKFLPA-KELPREWINNKEALLKYIEQAHIGIKGYVT DE-FGIPFHRAVIHVHG----------IRHDVTTNEKGEYWRMLLPGKYIVTAVKDELTD -TKWVHV--TNND-TTASRY--DFVLKQLPGRQRPNKQD-----------IDELDIHETE HQNQTTDKNV------------------------------------VQANFDEEPA---- ------------KIAEPK----------------------------------SSINKNSF SEVRTTDQAQTTTFDFSTSTVPS------IFTTG------------IEEEVSTQMTEINE ----TVVDAGIRIMTNLVEN------------------------------------ILSI ATGVRN-TTIIND-----------TNTTSQGVNTSSFEIDVTTESPNATYFGSGDGDETM ------------------------------------------------------------ ---------------------------IDKTNALEDTTAKIR-------------HVKES NMQTNVIIYEITFDQSNSEDSDT---DIMSSMTSDLN-------------FSNATAI-AQ NSSFDS----IQFDG------------SGDEE-------NATY---IESHSMKTNTTSEN VHNG-------------------------------------------------------K AELHEGAKLSIFKEESSTSLDS-----ANVPKISTKTH-------QKSEQEASKLAEVHV EAKWSTIKEE-SSISH---------DSANVPKI-------------------------ST KTHQKS--------------------EQETSI---SLSGKT----LNKEKFTSNRKLNNE ----------------------R >XP_038063978.1 carboxypeptidase E-like [Patiria miniata] -------------MHLVTS-----FVS-QIVAL--------------------------- ------------------------------ML---------------------------- ------------------------------------------------------------ ------LSLNLGFP---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------GSVAGQNGADHGIDFSY-QSHNELVV LLHQIAWKCRSITRLYD-IGRSVQGRRLYVLEMSDNPGVHEVGEAEFKYVANMHGNEATG RQLLIFLAQYLCEEYTKKNKRIQKLINSTRIHLLPTMNPDGFEMAYRRH----------- VVMGRVPSMYGRGNANNVDLNRDFPDLNDIMYKHEQTGGANNHLL--QLIRENK--EGR- -QPETQAIMDWMAQYPFVLSANMHDGDLVANYPYDKSRN----------TRKMYSATPDD NLFRELALTYSLYHRTMATRA--EPCRFQG-----------AKVF--RDGVTNGADWYIV SGGMQDYNYLSSNCFDITLELGCDKFPRE-EELKRKWEDNRESLIEYIDKVHIGIKGQVM DT-DRNPIANAVIRVTGPS--------IAHDVTTATDGDYWRLLLPGVYTVTVHARGYKP --KTVVV--PVRR-YRPTKA--NFILKPLPKESSGCKLRQ----------LEE------- ------------------------------------------------------------ ---------------EGY------------------------------------------ --LLGGFRAALRQFGFLGDDC---------------------------DGLVERREDVL- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------ASMEDTTASP------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_030835262.1 carboxypeptidase D [Strongylocentrotus purpuratus] -------------MT-------------LLLAL--------------------------- ----------------------------LAVL---------------------------- ------------------------------------------------------------ ----------PFFSSVLGE----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------PITATSEFPGSDYQWEH-HDQEALYQ ILRDTNEECPEITRIYS-AGESVEEEDLWVIEISDNPGKHEVGEPEFKYIGNMHGNEVVG REMLLLLIPYLCKNYET-DPDIKWLVDNTRIHIMPTMNPDGYAAALEQL----------- EERGENAWSTGRANAHEVDLNRNFPDLDRIIFGRRADRFPRRHGLNNHITSHVD--PRQ- LEPETRAIMSWLQEYPFILSANLHGGDIVANYPYDSSHD----------GKANYEASPDD QVFRQVSLAYATPHPVMSDPN-REQCDIGG-----------EDAF--KKGITNGADWYPL KGGMQDYNYLHTNCFEITIELSCKKFPSNPNDYEEFWGDNKQSLLDYIRQAHSGIKGTVT DE-NGVGIDDAKIKVWELTGPASEEHYIDHDITTADDGDFWRLLVPGTYKVEAEACGFHA VNKTCTVAEPGTN-VEASDC--SFQLEEDNSTEGCSIEE-----------LES-FLMNRL ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------YPTY----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_031559839.1 carboxypeptidase D-like [Actinia tenebrosa] -------------MRCL-----------KVLAL--------------------------- ------------------------------VL---------------------------- ------------------------------------------------------------ --CVHALTTFAKPPASLSKKSS-----------------AKVVKKSPT------------ ------------------KSPIQHL-----------APVKPELKA--------------- ------------------------------------------------------------ ---KVR-----AVKQKVTAVKQ-------------------QKHVVHEQKAAKEIPTK-- ---------------------VV-----------PKIKVEEIHEKNSSFRH-HNYEEMTW LLKEFARKHQDIARLYD-IGKSVQNRKLWVMEISDNPGKHEAEEPEVKYVANIHGNEVIG KEMLLHLIRYLCHNYGI-NKRVTNIVDATRIHILPSMNPDGYEMAATD------------ -----DDHQAGSKNANDIDLNRNFPDQ----FFPST--------------------TGP- PQPETHAVMKWVRSNPFVLSASLHAGALVASYPYDDNPS----------GKTSYSASPDD DVFREVARAYSQAHPTMHLANAPWKCKNKQ-----------KEHF--IDGITNGADWFSL SGGMQDYNYVHSNCFEVTLELGCEKFPNA-TALPEYWRENKEALLSFVEQANKGIHGIIQ DE-DDKPIKDARINIAN----------RPHDVFTSNKGDYWRLLVPGSYEVTVSAKGYEH ESKTATV--HS---SAATKL--DFTLRRIRERKPRHIEDNE------------------- ------------------------------------------------------------ ---------------DPR------------------------------------------ ----GSFTLRRSLRDFYRD-----------------------------ESPDQKKQN--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------Y--------------------------------------------------- ---------------------------DGDD--------DNDY----------------- ------------------------------------------------------------ -----GARRQVLD----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >CAE1309007.1 CPE [Sepia pharaonis] -------------M---------------------------------------------- ------------------------------LL---------------------------- ------------------------------------------------------------ ----------TSFPSS-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------VEAAVSTSFSSNADFIH-HNYSAMVD LLNEVNSKCPRITQVYNPPGHSVQNRNLTVIEFSDNPGHHTPGKPEFKYVANMHGNEVVG RELLLHLAVYLCQEYNANNHKIQWLINNTRIHLMPSMNPDGWELANTNHR---------- KPDGTKDWLIGRRNANNVDLNRNFPDLNNIMYENEISHGPNNHLE--KLKYALN--TPD- LEAETKTVMKWLSAYPFVLSANLHGGDLVANYPYDLTRSG---------KQKEYSISPDD ATFRYLAEAYSQNHRYMSKNH--KSCGMAN-----------DQNFGVQDGITNGGEWYSV SRGMQDYNYLETNCFEITLELGCNKFPKA-SELSRYWKDNKDALIAYMLQTHIGLKGFVK SSWLQLPIQDAVIQVINMT----DNKYINHDITTGRHGDYYRLLIDGYYQIRVIARGYHS QVRCHKV--HNKMFHEAEIL--DFVMIPQHQRNKRDVKERLYCK-----MLQE--LADNQ ------------------------------------------------------------ ------------------------------------------------------------ -----GHKLATEQEIF--------------------------------DEMMKDV----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------SEY----------------- -----------------------------------------------------------F NQ---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >NP_501935.1 Carboxypeptidase E [Caenorhabditis elegans] MLHA---------MRPV-----------LLVAA--------------------------- ------------------------------LL---------------------------- ------------------------------------------------------------ ------AVTAHAF----------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------LGFGSGSTHKDDAEWGHYHNQAQLEA KLGEINEKCPEITTLYE-IGQSVEGRPLVVIQFSTTPGEHIPTKPEVKLIGNMHGNEPIG RELLLRFAETLCNGAINNDKEIVQLLNSTSIHILPSMNPDGFELALG------------- TEPAQRQWLTGRSNINGVDLNRDFPDLDSIFYELQKIGVPKFDHLL-SLFE-----DNVD RQPETIAVGQWTLSLPFVLSANFHEGDLVANYPFDAAIDEN-------SQKTAYSASPDD GTFRWLAKSYADNHAHMSKND-HAPCDGTS-----------QDAFARQGGITNGAKWYSV AGGMQDFNYLATNAMEITLELSCEKMPEG-SQLPRFWEDNQKSIFEYVWKSHSGVKGMVV DAMTGEPIKRAVVWIRNGT----ETVPVKHPVTTWSEGDFYRVLPAGKYEIIVAAEGYDI AAKNVTV--ENKVRDSALVV--NFALSPAADEPSENEQEQ----------IAE------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------LVNEIARRR----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------- >XP_026296936.1 carboxypeptidase D isoform X2 [Apis mellifera] -------------MAHISIIYTVPFMI-LFVGIIYGFAINSENKLEENFIIPHYTHYEEL QQLFNSLVQKYPNLAKVFSIGKSVEGRNLLVL--EISENVKERKLCEPMVKYVANMHGDE AVGRELLVYLAQYLLHNYGKDERITKLINNTDIYLMPSMNPDGFEKSEEGKCESKKDFSG RENANHVDLNRNFPDQFDRRTNHLQKGGNILDGRQNETVAMMTWIATEPFVLSGNLHGGA VVASYPYDSGLTSCCTESKSPDDELF---KYLAHTYADNHPQMRTGRACESDVFQGGVIN GAYWYEVIGGMQDFNYARSNAFEITFELSCCKYPNASEMPEYWKLNKESLITYFEQAHIG IKGLVRDIDGQPIEGATIIVRGINHNVSSTNHGEYWRLLLPGTYYIHAEAWGYR-PSEPI NVIVKSGEPTIVNFTLKQDNYDQGELKSDKVEKIIKSIDKYGFLHNTEFKH-HNYIAMEK YLKELNLNYPNITRLYS-IGQSIKKRQLYVMEITENPGKHSKNKPEIKYIGNMHGNEVVG REILLLLLKYLCENF-GNDKRVTKILKNVRLHVMPSMNPDGYEISKE------------- ---GDVDGIQGRTNAKGVDLNRNFPDQ----YETNN--------------------YNKK QETETKAVMNWIASIPFVLSANFHGGALVANYPYDNKPEY---------AANGENPSPDD KVFKALALAYSNAHPRMHLGE---PCPSFSNGRLNTESNLLEKSF--PNGITNGAAWYSV NGGMQDYNYIHSNDFEITIEVGCTKFPNV-TELPNYWLQNREPLLRLIEMSRKGIHGVVR SS-IGNPIPHAKISIEG----------IKHDIYAANDGDYWRLLVPGKYNVTVNAVGYES QMQTVTI--SNGVNFGEGEVTLDFTLMRDDPEHWSSAYDFRLMANLQNVYLKNAELSARF SQLESHQPNITEFLAGESLINMDNIHSLKVTNNIGAPEENKFHIGLIGGLFASQPIGREI LLRLATHILMGNQIGDPPIERILNNSVLHFIPGIDPTFDDIFNIQDCNPIVYDEVGKELL QKNINLNKLNKTTNAFKTMLLNEGYDVIIILGSGALEVSYTDDNLNVYENLAKNYEHSLR KGTCNFLNNDIKEVQNYIKNQYNIPVISINMDCCKYPRPGSIPIIWRENLLPLKKLIHGL TTGIRAIVTDINDVPLRKAIVKIGTNNYHVSKNMAYFKIIVLPGEYMLIFFCEGYIEQTI KIHVNYESITNLYIKLIKHHIGKIEHQKYNEDQETNIVNQVLIDLNNKYSQLSILHTIGK SQIGTQIMCLEIGTENNKQIGRPSIAFIAGISNGAAVTSKILLYFAKYLLDHYQKDIRIT NYLNQFTIYIAPDLSQNSNDNQTCTSSIMNNLQFPINNELTTDASMIINWFKNINAVLAI NLNIGSQHIEIPFAGKYGKIHEQIYNTDDDDILQDLALLYTKYNIHMTSKDSQCNNNLNI NYNGIIRGGIGISGKREHSLMDYLYLNTSTLMLNIYVTCCNTDDSKSVWEDNKASLLAMI EKLNEGVKGYVLDENNHPIENAILSYNQSIHHIKSSIHGAYWLLFQPGTHVISATASKYI QQTKVFITPDIHNISYLIFKLKYDDNYLGMPRIVFIILLSTLCLGIVICSIFICISCQSS KNLEKNNWRQYSFSLLKDGTSFFDDDEKEIEIFKRPLNGHTQIKEITKPYFDDDNMSSSE DASDLEFVRPSKEWEEEPTKQHR
BMGE Cleaned alignment of selected proteins >sp|Q66K79|CBPZ_HUMAN Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ PE=1 SV=2 AARPGCEFPAGECHPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >sp|Q66K79-2|CBPZ_HUMAN Isoform 2 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ AARPGCEFPA---------ATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >sp|Q66K79-3|CBPZ_HUMAN Isoform 3 of Carboxypeptidase Z OS=Homo sapiens OX=9606 GN=CPZ ----------------------------------------------------------------------------------------------------------------MAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >tr|F6P711|F6P711_DANRE Carboxypeptidase Z OS=Danio rerio OX=7955 GN=cpz PE=3 SV=1 SFPQRCTQAIGRCRPAEEGPQCIEMVLGYCQDVPYTHTTFPNIVGHRTRQDLEMGAEYLLLSVIHGLMKGECSPDIRIVLAPRCENGRLMKPCRSSCEMLKKSCIHAFEAIQMAWPYFLDCDRFFVGSEEGCYDLREKQLANISDGGLSTVIQFTYHSNSQMFSILKKTASKCSHISQTYSIGRSVEGKDLLVIEFSNNPGQHDLLEPEIKLIGNMHGNEVLGRQLLIYLAQYLCSEYLLGNERIQTIINTTRIHILASMNPDGYEIAASEGHEYNGWTSGRANAQNLDLNRNFPDLTSIFYNRRRFRHFRSDHIPIPDSYWVAPETYAIMKWIRTYPFVISASLHGGELVISYPFDFSRHPQEDRMYSPTPDEQIFRQLARTYADAHATMSNNDGASFANKGGITNGALWYSFAGGMSDFNYLHSNCYEITVELGCDKFPSEEELYPEWRRNKEALLSFMESVHKGIKGIVKDEHGNGIKGAIISVKGLRHDITTAEDGDYWRLMNPGVHIVTASASGYSKQSKRINLTQVGRVDFVLKKV-----NQFEQYSQRELGRTEKPWFSQLGMAPTWLLRN >XP_038948430.1 carboxypeptidase Z isoform X1 [Rattus norvegicus] --DQGCLTHTGKCQASTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVEASPEYTLLGVLHFLLEGQCNPDLRLVLAPRCQGGHTQRPCRRVCEGLREACQPAFDAIDMAWPYFLDCTQYFAPEEEGCYDLRGELEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKHPHEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQHNKEPLLNFLEMVHRGIKGVVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIKRAGRVDFILQPLGAPAQLDFEPPRARRQPSGSKPWFTSLSPKPRWLLKY >NP_694747.2 carboxypeptidase Z precursor [Mus musculus] RPSPSCSPPSGKCQVYTHSATCVDLHLRTCADAAYNHTSFPTPLEHRSWEAVESSPEYMLLGVIHFLLEGQCNPDLRLVLAPRCEGGHTQRPCRHVCEGLREACQPAFDAIDMAWPYFLDCAQYFAPEEEGCYDLRGELEEALPSGLPPTFIRFAHHSYAQMVRVLKRTAARCSQVAKTYSIGRSFEGKDLVVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREVLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASTRGVRTDHIPISQYYWVAPETKAIMKWIQTIPFVLSASLHGGDLVVSYPFDFSKNPHEKKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYGLWQQNKEPLLNFLEMVHRGIKGMVTDKYGKPVKNARILVKGIRHDVTTAPDGDYWRLLPPGSHIVIAQAPGYSKVMKRVTIKKAGRVDFILHPLREPTQMDFEPPRARRQPSGSKPWFTSLSPKPRWLLKY >NP_989909.3 carboxypeptidase Z precursor [Gallus gallus] EPAPRCETTLGQCQ-AAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVIEYSSEYILISVLHNLLQGECNPDLRLVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFDLRGEVEEDLPSDFPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYWVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKMFKMLAKAYADAHPVISDRSGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRDALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDITTAADGDYWRLLPPGTYIVTAQAMGYTKVMKRVTLKRAGRVDFVLRPI-----ELFDPHTQHAQAVREKPWFSSLDLKPLWLLKQ >NP_001289340.1 carboxypeptidase Z precursor [Pan troglodytes] AARPGCEFPAGECHPAADSATCMDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTGGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >XP_038322250.1 carboxypeptidase Z isoform X1 [Canis lupus familiaris] ------------------------MQLRTCSDVAYNWTTFPTLLEQRSREAVESSSEYILLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASVEEGCYDLREGLEEALPSGLPPTFIHFTHHSYAQMVRVLRRTAARCAHVAKTYSIGRSFNGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASSRSVRSDHIPIPQHYWVAPETKAIMKWMRTTPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTLWQHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGPHIVIAQAPGYSKVIKKVTIKRAGRVDFILQPLGEPEEVGQEPLGGRRQPGGSKPWFTSLSQKPRWLLKY >NP_001076955.1 carboxypeptidase Z precursor [Bos taurus] AARPGCEPPEGGCPAAADSAMCVDLQLQTCSDVTYNRTAFPTLLQHRSREAVESSSEYILLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDLRGGLEEALPSGHPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLFYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSNHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDDKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCMKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLGEPQEPDEEPLGARRQPGGSKPWFTSLGQQPRWLLKY >XP_024102119.1 carboxypeptidase Z isoform X1 [Pongo abelii] AARPGCEFPAGECHPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSREVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREACQPAFDAIDMAWPYFLNCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVEMVHRGIKGVVTDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGVHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >XP_010708822.1 carboxypeptidase Z [Meleagris gallopavo] EPAPRCETTLGQCQ-TAQKAKCVDISLSSCTDVTYTQTMYPNFLDQKSREVIEYSSEYILISVLHNLLQGECNPDLRLVLAPQCEKDKVIKPCRHVCENLKKNCLSAFDAIDMAWPYFLDCDRFFAGEEEGCFDLRGEVEEDLPSDLPATFIQFKHHSYSQMVSTLKKTASRCSHIATTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAGIRGARLDHIPIPQSYWVAPETKAVMKWMRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKEFSPTPDEKLRISGKLGFLLLSPAVR-----------------EWIRPTS---------------------RSLP--------------------EPVPRS----CSSAHESPREAPRL---------------EYFRGWAPG---------------------------------------------------------------------- >XP_034807806.1 carboxypeptidase Z isoform X1 [Pan paniscus] AARPGCEFPAGECHPAADSATCMDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSQHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGSKPWFTSLSTRPRWLLKY >XP_003985597.3 carboxypeptidase Z [Felis catus] ----------------------------------------------------------------------------------------------------------------MAWPYFLDCGSYFASVEEGCHDLRGGLEEALPSGPPPTFIHFTHHSYAQMVRVLRRTAARCAHIAKTYSIGRSFDGKELLVIEFSARPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGSPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEFYRLEASGSIRSSRIPIPQHYWVAPETKAIIKWMRTTPFVLSASLHGGDLVVSYPFDLSKHSQEEK-FSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSKVIKKVTIKRAGRVDFILQPLGEPQEPGQEPLGARRQPGGSKPWFTSISQKPRWLLKY >XP_027827070.1 carboxypeptidase Z [Ovis aries] AARPGCEPPEGACSAAADSATCVDLQLQTCSDVTYNRTAFPTLLQHRTRAAVESSSEYILLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDLRGGLEEALPSGYPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHIAIPQHYWVAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLGEPQEPDQEPLGARRQPGGSKPWFTSLGQQPRWLLKY >XP_030866357.1 carboxypeptidase Z [Gorilla gorilla gorilla] AARPGCEFPAGECHPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDLRGGLDEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWVAPETKAVMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYTLWQHNKESLLNFMEMVHRGIKGVVTDKFGKPLKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIVQAPGYAKVIKKVIIKRAGRVDFILQPLGEATEP--DPLRARRQPDGNKPWFTSLSTRPRWLLKY >XP_023816686.1 carboxypeptidase Z isoform X1 [Oryzias latipes] APQHTCHPLLGRCSARQDRAACTELNLGYCNDLDYSRTIFPNILGHQSRVEAESGAEYLLLSVIHGLLNGECSPEIRLVLASPCRDDKMIKPCRRTCEALRKDCSHAFEAIEMAWPYFLDCDRFFASDQEGCFDLKAKQLSSLSPEEPSTIIQFTYTSNSQMYSLLKRTAAKCAHISHVYSIGRSTEGRDLLVIEFTNNPGQHELLEPEVKMVGNMHGNEVLGRQLLIYLAQYLCSEYNLGNQRIQSIINSTRIHILASMNPDGYELASSEGHLLNGWTNGRSNAQNIDLNRNFPDLTSIFYRNRRSRHYRTDHIPIPDGYWVAPETYAVMKWIRSLPFVQSASLHGGELVVSYPFDFSRHPQEERMFSPTPDEQAFKQMARTYADAHATMSNNDGASFYWNRGIINGALWYSFAGGMSDFNYLHTNCMEITVELGCDKFPPEAELYPEWKRNKEALLSFLESVHRGIKGEVKDTDGNGIKGATVSVRGIRKDVTTAEDGDYWRLLNPGTYIVTATAKGYSKVSKRVHLNKAGRVDFVLEKV-----NQFERFSE---GRQEKPWFSQSGIPPTWLLRN >XP_005498499.1 carboxypeptidase Z [Columba livia] KPAPRCETTLGQCQ-SVQKAKCVDITLSSCTDVAYTQTMYPNFLDQKTREVIEYSSEYILISVLHNLLQGECNPDLRLVLAPQCEKDKVIKPCRHVCENLKKNCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFDLRGEVEEDLPSDLPGTFIQFKHHSYSQMVSTLKKTASKCSHIATTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQTLINNTRIHLLPSLNPDGYELAAEEGAGYNGWVIGRQTAQNLDLNRNFPDLTSEAYRRAEIRGARLDHIPIPQSYWVAPETKAVMKWLRSIPFVLSASLHGGELVVTYPYDYSRHPMEEKMFSPTPDEKMFKMLAKAYADAHPVISDRSGGNFVKRGGIINGAEWYSFTGGMADFNYLHTNCFEVTVEVGCEKFPLEEELFTIWHENRDALLNYMEMVHRGIKGIVSDKFGNPIKNARISVRGIQHDVTTAADGDYWRLLPPGTYIISAQASGYSRVIKRVTIKQAGRVDFVLRPA-----ELFDPHAQHRQAGREKPWFSSLGLKPLWLLKQ >XP_017905285.1 PREDICTED: carboxypeptidase Z [Capra hircus] AARPGCEPPEGACSVAADSATCVDLQLQTCSDVTYNRTAFPTLLQHRTRAAVESSSEYILLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEGCYDLRGGLEEALPSGYPPTFIQFTHHSYAQMVRVLRRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGVRSDHIAIPQHYWVAPETKAVMKWMRAIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFVEMVHRGIKGMVMDKFGKPVKNARILVKGIRHAITTAPDGDYWRLLPPGAHIVIAQAPGYSRVIKKVIIKRAGRVDFILQPLGEPQEPDQEPLGARRQPGGSKPWFTSLGQQPRWLLKY >XP_006017072.1 carboxypeptidase Z [Alligator sinensis] EPAPRCETTLGQCQ-AEQKAKCVDITVGTCNDVPYSKTMYPNLLDQKARQAVEYSSEYILISVIHNLLQGECNPDLRLILAPQCEKDKIIKPCRHICEKLKKSCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFDLRGELEEDPLAGLPTTFIQFTHHSYSQMVSILKRTASKCSHIARTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQMLINHTRIHLLPSLNPDGYDLAAEEGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHIPIPQSYWVAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPLEEKMFSPTPDEKMFKLLAKAYADAHPIISDKSGGSFGKRGGIINGAEWYSFPGGMADFNYLHTNCFEITVEVGCEKFPLEEELYSIWHENRESLLNFIEMVHRGIKGIVSDKLGNPIKNARISVRGIRHDVTTADDGDYWRLLPPGTYIISAHAVGYSKVIKKVTLKRAGRVDFVLRPS-----EHFDPHAQHAQPNRERPWFSSLDQKPMWLLKR >XP_006264271.1 PREDICTED: carboxypeptidase Z [Alligator mississippiensis] EPAPRCETTLGQCQ-TEQKAKCVDITVGTCNDVPYSKTMYPNLLDQKARQAVEYSSEYVLISVIHNLLQGECNPDLRLILAPQCEKDKIIKPCRHICEKLKKSCLPAFDAIDMAWPYFLDCDRFFAGEEEGCFDLRGELEEDPLAGLPTTFIQFTHHSYSQMVSILKRTASKCSHIARTYSIGRSFEGKDLFVIEFSTKPGHHELLKPEFKYIGNMHGNEVVGKELLIYLAQYLCSEYLLGNPRIQMLINHTRIHLLPSLNPDGYDLAAEEGAGYNSWINGRQTAQNLDLNRNFPDLTSEVYARARIRGARIDHIPIPQSYWVAPETKAIMKWMRDIPFVLSASLHGGELVVTYPYDYSRHPLEEKMFSPTPDEKMFKLLAKAYADAHPIISDKSGGSFGKRGGIINGAEWYSFPGGMADFNYLHTNCFEITVEVGCEKFPLEEELYSIWHENRESLLNFIEMVHRGIKGIVSDKLGNPIKNARISVRGIRHDITTADDGDYWRLLPPGTYIISAHAVGYSKVIKKVTLKRAGRVDFVLRPS-----EHFDPHAQHAQPNKERPWFSSLGQKPMWLLKR >XP_015827050.1 PREDICTED: carboxypeptidase Z-like isoform X1 [Nothobranchius furzeri] VPQRRCHPFLGMCSAQEVTPTCTEMNLGYCNDVEYTRTIFPNILGHRSRLEVESGAEYLLLSVIHALLNGECSPEIRLVLASPCRDNKMIKPCRSTCEALRKDCRHAFDAIEMAWPYFLDCDRFFASEEEGCFDLKARQLSSLSPEEPSTIIQFTYTSNAQMYSLLKRTAAKCSHISHVYSIGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLGRQLLIYLAQYLCSEYILGNQRIQTIINTTRIHILASMNPDGYELAASEGHLLNGWTNGRTNAQNLDLNRNFPDLTSIFYRNRRSRHYRSDHIPIPDSYWVAPETYAVMKWIRSLPFVQSASLHGGELVISYPFDFSKHPHEEKMFSPTPDEQVFKQLARTYADAHATMSNNDGASFYRNRGIINGALWYSFAGGMSDFNYLHTNCMEITVELGCDKFPSEAELYPEWKRNKEALLSFLESVHRGIKGVVKDLDGNGIKGATVSVRGIRRDVTTAEDGDYWRLLNPGTHILTATAKGFSKVSKRVYLNKAGLVDFVLEKV-----NQFERYSSPDVAREEKPWFSQSGIPPNWLLRN >XP_020745074.1 carboxypeptidase Z [Odocoileus virginianus texanus] SPVDVFTPPSG-CPAAADSAMCVDLQLQSCSDVAYNRTAFPTLLQHRSH--------------VGYWLERQ--PDVSE----RGPGNR-------------------------------------------------GLEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKLPPP---------------------------------HWAAGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLGEPQEPDQDPLGARRQPGGSKPWFTSLGQQPRWLLKY >XP_043304186.1 carboxypeptidase Z [Cervus canadensis] AARPGCEPPEGGCPAAADSATCVDLQLQSCSDVAYNRTAFPTLLQHRSRAAVESSPEYVLLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDLRGGLEEALPSSYPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLEEPQEPDQDPLGARRQPGGSKPWFTSLGQQPRWLLKY >KAB0344502.1 hypothetical protein FD754_021428 [Muntiacus muntjak] AARPGCEPPEGGCPAASDSATCVDLQLQSCSDVAYNRTAFPTPLQHRSRAAVESSSEYVLLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDLRGGLEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLEEPQEPDQDPLGARRQPGGSKPWFTSLGQQPRWLLKY >KAB0354429.1 hypothetical protein FD755_022967 [Muntiacus reevesi] AARPGCEPPEGGCPAGSDSATCVDLQLQSCSDVAYNRTAFPTPLQHRSRAAVESSSEYVLLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDLRGGLEEALPSSHPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLEEPQEPDQDPLGARRQPGGSKPWFTSLGQQPRWLLKY >KAF4013199.1 hypothetical protein G4228_004643 [Cervus hanglu yarkandensis] -----------------PPATCVDLQLQSCSDVAYNRTAFPTLLQHRSRAAVESSPEYVLLSVLHHLLEGQCNPDLRLVLAPRCEGGRVRRPCRHVCGALREACQPAFDAIDMAWPYFLDCGRYFSGPEEDCYDLRGGLEEALPSSYPHTFIQFTHHSYAQMVRVLKRTAARCAHISKTYSIGRSFDGRDLLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLASVRGARSDHIAIPQHYWVAPETKAIMKWMRTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTIWQHNKEPLLNFMEMVHRGIKGMVMDKFGKPVKNARILVKGIRHDITTAPDGDYWRLLPPGAHIVIAQAPGYSKVIKKVIIKRAGRVDFILQPLEEPQEPDQDPLGARRQPGGSKPWFTSLGQQPRWLLKY >XP_041443673.1 carboxypeptidase Z isoform X1 [Xenopus laevis] HCSPNCPPALGRCMTAEERGTCVDNILGYCNDLPYSKTMFPNALDQQSRGEIEYSAEYILLSVIDNLLQGECNPDLRIVLAPRCEKNKMVKPCRRVCEMLKKNCLPAFDAIDMAWPYFLDCDRFFVGEEEGCHDLRVNIPEDLLPENPSTFIQFIHHSYSEMVRVLKKTAAKCSQISKTYSIGRSYEGKDLLVIEFSANPGQHEVLTPEFRYIGNMHGNEVVGRELLIYLAQFLCSEYLLGNSRIQTLINTTRIHLLPSMNPDGYEHAAEMGAGYNGWTNGRQNAQNIDLNRNFPDLTSEAHKLIRMPLARLDHMPIPESYWIAPETKAVMKWMRSIPFVISGSLHGGDLVISYPYDFSRHPLEEKMLSPTPDEKVFQLLAKTYVAAHPMMSDKSGGNFNSKGGIINGAEWYSFSGGMADFSYLHTNCFELTLELGCEKFPTEDELYSIWQNNKEAMLGLIEMVHRGIKGIVKDEYGNPIKKARISVRGIRHDIITGEDGDYFRLLIPGSHIVSAEAFGYSRVTKKITLLKAGRVDFVLQRV-----DRFDPHAQHGGANGEKPWFSMLGHRPSWLLKK >XP_020956608.1 carboxypeptidase Z [Sus scrofa] AARPGCEPPAGGCPAAVDSATCVDLQLRTCSDAAYNQTAFPTLLEHRSREVVESSSEYVLLSVLHHLLEGQCNPDLRLVLAPRCQGGQVRRPCRHVCEGLREACQPAFDAIDMAWPYFLDCGRYFASQQEGCYDLRGGLEEALPSGHPATFIHFTHHSYAQMVRVLKRTAARCAHIAKTYSIGRSFDGRELLVLELSSRPGQHELMEPEVKLIGNIHGNEVAGREILIYLAQYLCSEYLLGNDRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRTASARGARSDHIAIPQHYWVAPETKAIMKWMRAVPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLARAYADVHPMMMDRSGGNFLKRGSIINGADWYSFTGGMSDFNYLHSNCFEITVELGCVKFPPEEALYTLWQHNKEPLLNFVEMVHRGIKGVVMDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGSHIVIAQAPGYSKVIKKVTIKRAGRVDFILQPLGEPEEPGQEPLGARRLPSGSKPWFRSLGQQPRWLLKY >XP_030290269.1 carboxypeptidase Z-like isoform X1 [Sparus aurata] APQQTCHPLLGRCSDFEEKPKCTELNLGYCNDMEYSRTMFPNILGHRNRMEAESGPEYLLLSVIHALLNGECTPEIRLVLASPCQNDKMIRPCRSTCEALRKDCGHSFEAIEMAWPYFLDCDRFFASDQEGCFDLKARQLSSLSPEEPSTIIQFTYTSNAQMYSLLKRTAAKCSHISQVYSIGRSTEGRDLLVIEFTDNPGQHELLEPEIKLVGNMHGNEVLGRQLLIYLAQYLCSEYILGNQRIQTLINTTRIHLLASMNPDGYELAAAEGHLFNGWISGRANAQNIDLNRNFPDLTSLFYRNRRSRHYRIDHIPIPDAYWVAPETYAVMKWIRALPFVQSASLHGGELVISYPFDFSRDVHEEKMFSPTPDEQAFKQLARTYADAHATMSNNDGASFYRTRGIINGALWYSFAGGMSDFNYLHTNCLEITVELGCDKFPSEAELYPEWKRNKEALLSFMESVHRGIKGVVKDTDGNGIKGATISIRGIRKDVTTAEDGDYWRLLNPGTHIMTATAKGFSRVSKRVHLNKAGRVDFVLEKV-----NQFERYSEPVVGREEKPWFSQSGIPPNWLLRN >XP_040191293.1 carboxypeptidase Z [Rana temporaria] YASPRCLPALGRCVPASEKGTCTDNVLGYCDDLPYSKTMYPNSLDHRSRGDTEFSAEYILLSVIDNLLQGECNPDLRLVLAPRCEKNKIVKPCRKICETLKKNCLPAFDAIDMAWPYFLDCDRFFASDEEGCHDLRVNIPDDSLPQMPNTFIDFSHHSYAQMVSILKKTAGKCSHIAKTYNIGRSFEGKDLIVIEFSTKPGQHEPLKPEFRYIGNMHGNEVVGRELLIYLAQYLCSEYLLGNPRIQELINTTRIHLFPSMNPDGYELASEEGAGYNGWTNGRMTAQNIDLNRNFPDMTSEVHKIMKVRSARVDHLPIPETYSVAPETKAVMKWMRNIPFVLSGSLHGGDLVVSYPYDFSKHPLEEKMFSPTPDEKVFTMLAKTYVASHPKMSDQAGGNFVRKGGIINGAEWYSFSGGMSDFSYLHTNCFELTLELGCEKFPTVDELYTAWKDNKESLLSFIEMVHRGIKGVVKDEHGNAIKNARISVKGIRHDIMTAEDGDYWRLLIPGVYIVSAEAFGYSKVTKKITLTKAGQVDFALKRV-----DSYDPHARRGQEDREKPWFSILGHRPMWLLKN >XP_039260303.1 carboxypeptidase Z-like [Styela clava] -----CFCTHEKSAKFKNSGECQWVSLPICQQVARSWANFPNLLGHRNQIEIANSSAYKYLSIGNSLLLERCTLQIYQFLVPKCVYVDRIQPCKSTCMEVRERCESILHSEEMEWPEFLDCESWVQ-----CHLRHSDAIQLVTRRRKIPRVEFKHHSELAARKVMTRLTRQCPGIMRLYTIGRSVKNKPLYVMEISDNAGMHEALEPEVKYIGAIHGNEVLGRELLLQLMQHICREWLLGNERIRNIVRNTRIHLLPTMNPDGYSVAARQGPERNGWLTGRFNSRDHDLNRHFPDLTKIAYINEA-KFARNHHLEIPKRYWSFPEIYAVIKWLENYDFTLSAQLHGGELVANYPYDVRRKTSPELMYSKSPDDKVFRHLASTYAENHGTMADPVEEKFGRRGGITNGAAWYTISGGMQDFNYLYTNSFEILIELSCRKFLPAKELPREWINNKEALLKYIEQAHIGIKGYVTDEFGIPFHRAVIHVHGIRHDVTTNEKGEYWRMLLPGKYIVTAVKDELTD-TKWVHVTTASRYDFVLKQLAQTTTFDFEEVSTQMTETTAKIRKAELHEAKLSIFKE >XP_038063978.1 carboxypeptidase E-like [Patiria miniata] ---------------------------------LSLNLGFP--------------------------------------------------------------------------------------------------GSVAGQNGADHGIDFSYQSHNELVVLLHQIAWKCRSITRLYDIGRSVQGRRLYVLEMSDNPGVHEVGEAEFKYVANMHGNEATGRQLLIFLAQYLCEEYTKKNKRIQKLINSTRIHLLPTMNPDGFEMAYRVVMGRVPSMYGRGNANNVDLNRDFPDLNDIMYKHEQTGGANNHLLQLIRENK-QPETQAIMDWMAQYPFVLSANMHDGDLVANYPYDKSRN--TRKMYSATPDDNLFRELALTYSLYHRTMATRAAKVF--RDGVTNGADWYIVSGGMQDYNYLSSNCFDITLELGCDKFPREEELKRKWEDNRESLIEYIDKVHIGIKGQVMDTDRNPIANAVIRVTGIAHDVTTATDGDYWRLLLPGVYTVTVHARGYKP--KTVVVYRPTKANFILKPLAALRQFGFDGLVERREDTTASP--------------- >XP_030835262.1 carboxypeptidase D [Strongylocentrotus purpuratus] -------------------------------------PFFSSVLGE---------------------------------------------------------------------------------------------PITATSEFPGSDYQWEHHDQEALYQILRDTNEECPEITRIYSAGESVEEEDLWVIEISDNPGKHEVGEPEFKYIGNMHGNEVVGREMLLLLIPYLCKNYET-DPDIKWLVDNTRIHIMPTMNPDGYAAALEEERGENAWSTGRANAHEVDLNRNFPDLDRIIFGRRADRFPRRHGLHITSHVDLEPETRAIMSWLQEYPFILSANLHGGDIVANYPYDSSHD--GKANYEASPDDQVFRQVSLAYATPHPVMSDPNEDAF--KKGITNGADWYPLKGGMQDYNYLHTNCFEITIELSCKKFPSNNDYEEFWGDNKQSLLDYIRQAHSGIKGTVTDENGVGIDDAKIKVWEIDHDITTADDGDFWRLLVPGTYKVEAEACGFHAVNKTCTVVEASDCSFQLEED------------------------------------- >XP_031559839.1 carboxypeptidase D-like [Actinia tenebrosa] -----------------------------CVHALTTFAKPPASLSKKSSKVVKKSPT----SPIQHL--APVKPELKA----------KVRAVKQKVTAVKQ-------------------QKHVVHEQKAAKE-----PKIKVEEIHEKNSSFRHHNYEEMTWLLKEFARKHQDIARLYDIGKSVQNRKLWVMEISDNPGKHEAEEPEVKYVANIHGNEVIGKEMLLHLIRYLCHNYGI-NKRVTNIVDATRIHILPSMNPDGYEMAAT-----DDHQAGSKNANDIDLNRNFPDQ----FFPST----------------PQPETHAVMKWVRSNPFVLSASLHAGALVASYPYDDNPS--GKTSYSASPDDDVFREVARAYSQAHPTMHLANKEHF--IDGITNGADWFSLSGGMQDYNYVHSNCFEVTLELGCEKFPNATALPEYWRENKEALLSFVEQANKGIHGIIQDEDDKPIKDARINIANRPHDVFTSNKGDYWRLLVPGSYEVTVSAKGYEHESKTATVSAATKLDFTLRRILRRSLRDFESPDQKKQN------------ARRQVLD- >CAE1309007.1 CPE [Sepia pharaonis] -------------------------------------TSFPSS------------------------------------------------------------------------------------------------VEAAVSTSFSSNADFIHHNYSAMVDLLNEVNSKCPRITQVYNPGHSVQNRNLTVIEFSDNPGHHTPGKPEFKYVANMHGNEVVGRELLLHLAVYLCQEYNANNHKIQWLINNTRIHLMPSMNPDGWELANTKPDGTKDWLIGRRNANNVDLNRNFPDLNNIMYENEISHGPNNHLEKLKYALNLEAETKTVMKWLSAYPFVLSANLHGGDLVANYPYDLTRSG-KQKEYSISPDDATFRYLAEAYSQNHRYMSKNHDQNFGVQDGITNGGEWYSVSRGMQDYNYLETNCFEITLELGCNKFPKASELSRYWKDNKDALIAYMLQTHIGLKGFVKSSLQLPIQDAVIQVININHDITTGRHGDYYRLLIDGYYQIRVIARGYHSQVRCHKVHEAEILDFVMIPQLATEQEIFDEMMKDV--------FNQ----------- >NP_501935.1 Carboxypeptidase E [Caenorhabditis elegans] ---------------------------------AVTAHAF---------------------------------------------------------------------------------------------------LGFGSGSTHKDDAEWGHHNQAQLEAKLGEINEKCPEITTLYEIGQSVEGRPLVVIQFSTTPGEHIPTKPEVKLIGNMHGNEPIGRELLLRFAETLCNGAINNDKEIVQLLNSTSIHILPSMNPDGFELALGTEPAQRQWLTGRSNINGVDLNRDFPDLDSIFYELQKIGVPKFDHLSLFE---RQPETIAVGQWTLSLPFVLSANFHEGDLVANYPFDAAIDENQKTAYSASPDDGTFRWLAKSYADNHAHMSKNDQDAFARQGGITNGAKWYSVAGGMQDFNYLATNAMEITLELSCEKMPEGSQLPRFWEDNQKSIFEYVWKSHSGVKGMVVDATGEPIKRAVVWIRNVKHPVTTWSEGDFYRVLPAGKYEIIVAAEGYDIAAKNVTVDSALVVNFALSPA--------NEIARRR---------------------- >XP_026296936.1 carboxypeptidase D isoform X2 [Apis mellifera] KERKLCEPAVGRELEKSEEGKCKDFSGRENANHVDLNRNFPDQFDRRTNMMTWIATEPFVLSPDDELTYADNHPQMRTFEQAHIGIKGLVRPIEGATIIVRGINHNVSSTNHGEYWRLLLPGTYYIHAEAWGYRLKQDNIKSIDKYGFLHNTEFKHHNYIAMEKYLKELNLNYPNITRLYSIGQSIKKRQLYVMEITENPGKHSKNKPEIKYIGNMHGNEVVGREILLLLLKYLCENF-GNDKRVTKILKNVRLHVMPSMNPDGYEISKE---GDVDGIQGRTNAKGVDLNRNFPDQ----YETNN----------------QETETKAVMNWIASIPFVLSANFHGGALVANYPYDNKPEY-AANGENPSPDDKVFKALALAYSNAHPRMHLGEEKSF--PNGITNGAAWYSVNGGMQDYNYIHSNDFEITIEVGCTKFPNVTELPNYWLQNREPLLRLIEMSRKGIHGVVRSSIGNPIPHAKISIEGIKHDIYAANDGDYWRLLVPGKYNVTVNAVGYESQMQTVTIFGEGEVDFTLMRDLNKTTNAFENLAKNYEHVTSKILIEKLNEVKGYVLDE
PhyML tree of selected proteins (XP_038063978_1_carboxypeptidase_E_like__Patiria_miniata_:0.89115316,(XP_039260303_1_carboxypeptidase_Z_like__Styela_clava_:1.12736073,((tr_F6P711_F6P711_DANRE_Carboxypeptidase_Z_OS_Danio_rerio_OX_7955_GN_cpz_PE_3_SV_1:0.14927531,(XP_015827050_1_PREDICTED__carboxypeptidase_Z_like_isoform_X1__Nothobranchius_furzeri_:0.0388206,(XP_023816686_1_carboxypeptidase_Z_isoform_X1__Oryzias_latipes_:0.07223579,XP_030290269_1_carboxypeptidase_Z_like_isoform_X1__Sparus_aurata_:0.06984901):0.02313125):0.18731614):0.21266244,((((XP_006017072_1_carboxypeptidase_Z__Alligator_sinensis_:0.00373489,XP_006264271_1_PREDICTED__carboxypeptidase_Z__Alligator_mississippiensis_:0.00570823):0.0720253,(XP_005498499_1_carboxypeptidase_Z__Columba_livia_:0.0255004,(NP_989909_3_carboxypeptidase_Z_precursor__Gallus_gallus_:0.00201592,XP_010708822_1_carboxypeptidase_Z__Meleagris_gallopavo_:0.1251159):0.02775569):0.08003125):0.09330131,((XP_038948430_1_carboxypeptidase_Z_isoform_X1__Rattus_norvegicus_:0.02552333,NP_694747_2_carboxypeptidase_Z_precursor__Mus_musculus_:0.02813681):0.09070005,((XP_024102119_1_carboxypeptidase_Z_isoform_X1__Pongo_abelii_:0.00208024,(XP_030866357_1_carboxypeptidase_Z__Gorilla_gorilla_gorilla_:0.00965091,((NP_001289340_1_carboxypeptidase_Z_precursor__Pan_troglodytes_:0.00191601,XP_034807806_1_carboxypeptidase_Z_isoform_X1__Pan_paniscus_:0.00000001):0.00384452,(sp_Q66K79_2_CBPZ_HUMAN_Isoform_2_of_Carboxypeptidase_Z_OS_Homo_sapiens_OX_9606_GN_CPZ:0,(sp_Q66K79_3_CBPZ_HUMAN_Isoform_3_of_Carboxypeptidase_Z_OS_Homo_sapiens_OX_9606_GN_CPZ:0.00000001,sp_Q66K79_CBPZ_HUMAN_Carboxypeptidase_Z_OS_Homo_sapiens_OX_9606_GN_CPZ_PE_1_SV_2:0.00000001):0):0.0019205):0.00192476):0.00755977):0.06200795,((XP_003985597_3_carboxypeptidase_Z__Felis_catus_:0.04377976,XP_038322250_1_carboxypeptidase_Z_isoform_X1__Canis_lupus_familiaris_:0.01635273):0.01970225,(XP_020956608_1_carboxypeptidase_Z__Sus_scrofa_:0.04404492,(NP_001076955_1_carboxypeptidase_Z_precursor__Bos_taurus_:0.01402606,((XP_017905285_1_PREDICTED__carboxypeptidase_Z__Capra_hircus_:0.00767845,XP_027827070_1_carboxypeptidase_Z__Ovis_aries_:0.00000001):0.01390299,(XP_020745074_1_carboxypeptidase_Z__Odocoileus_virginianus_texanus_:0.07367237,((KAB0354429_1_hypothetical_protein_FD755_022967__Muntiacus_reevesi_:0.00189995,KAB0344502_1_hypothetical_protein_FD754_021428__Muntiacus_muntjak_:0.00000001):0.00381022,(XP_043304186_1_carboxypeptidase_Z__Cervus_canadensis_:0.00000001,KAF4013199_1_hypothetical_protein_G4228_004643__Cervus_hanglu_yarkandensis_:0.00404117):0.00380661):0.00251009):0.01453437):0.00180901):0.04089459):0.01605348):0.02233472):0.02509634):0.30565663):0.08163414,(XP_041443673_1_carboxypeptidase_Z_isoform_X1__Xenopus_laevis_:0.13996018,XP_040191293_1_carboxypeptidase_Z__Rana_temporaria_:0.14428606):0.10766507):0.12716604):0.53331829):0.26593872,((XP_030835262_1_carboxypeptidase_D__Strongylocentrotus_purpuratus_:1.01205301,(XP_031559839_1_carboxypeptidase_D_like__Actinia_tenebrosa_:0.67818932,XP_026296936_1_carboxypeptidase_D_isoform_X2__Apis_mellifera_:1.15247031):0.32093786):0.15575514,(NP_501935_1_Carboxypeptidase_E__Caenorhabditis_elegans_:1.2923976,CAE1309007_1_CPE__Sepia_pharaonis_:0.75511774):0.12954948):0.17499925);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)