PB0162

DATABASE

Click here to access PB0162 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0162	P05156	Complement factor I	CFI	AHUS3, ARMD13, C3BINA, C3b-INA, FI, IF, KAF	Homo_sapiens	The presence of these cofactors on healthy cells allows degradation of deposited C3b by CFI in order to prevent undesired complement activation, while in apoptotic cells or microbes, the absence of such cofactors leads to C3b-mediated complement activation and subsequent opsonization (PubMed:28671664).

Domains

Gene Ontology

PF00057 (2_Ldl_recept_a) PF00089 (Trypsin) PF00530 (SRCR)

GO:0004252 (enables) serine-type endopeptidase activity GO:0005044 (enables) scavenger receptor activity GO:0005515 (enables) protein binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0046872 (enables) metal ion binding GO:0002376 (involved in) immune system process GO:0006508 (involved in) proteolysis GO:0006897 (involved in) endocytosis GO:0006958 (involved in) complement activation, classical pathway GO:0045087 (involved in) innate immune response GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0016020 (located in) membrane GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P05156|CFAI_HUMAN Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >tr|A0A0G2L5F9|A0A0G2L5F9_DANRE Complement factor I OS=Danio rerio OX=7955 GN=cfi PE=1 SV=2 MQYVELEGEDWPDQCMKVRCTGSELSLAECTIYNPTPIKEKQQVAVANCYNETTKEQSMK FRCVNGKYVNYGKLCDGIDDCGDNSDEMCCQDCQKKTNAFWCPSGVCIPRHAVRDGVRDC LGGEDELEENGPIVENDPKEFFTDPLAEIKKIRSTAESKLQCGVPNMDYVYKAEDDGSSR QRRKRLVGGEESLPTQIQWQVAIQDEGSIHCGGVYLGGCWVLTAAHCVRPKPKSFRVKFS LWRKNRKQSTTDSIPVKKIIIHENYDAQTYVNDIALVQLEELNLSDKCMLDNPAIRAVCV PWSTQQFQPNDTCTISGWGRDKAGMSASILKWANVTIIGDCQNFYKHRFLPGMECAGDLE GKVDSCQGDSGGPLVCKDASGLSYVWGIVSWGDKCGEPNHPGVYTKVAHYFDWIRFNTGW AAVTKFNQ
Selected proteins from model organisms >sp|P05156|CFAI_HUMAN Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2 MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCV CKLPYQCPKNGTAVCATNRRSFPTYCQQKSLECLHPGTKFLNNGTCTAEGKFSVSLKHGN TDSEGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTE CLHVHCRGLETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKA CDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVT QEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVGGKRAQLGDLPWQVAIKDA SGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHEN YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNER VFSLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYV WGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >tr|A0A0G2L5F9|A0A0G2L5F9_DANRE Complement factor I OS=Danio rerio OX=7955 GN=cfi PE=1 SV=2 MQYVELEGEDWPDQCMKVRCTGSELSLAECTIYNPTPIKEKQQVAVANCYNETTKEQSMK FRCVNGKYVNYGKLCDGIDDCGDNSDEMCCQDCQKKTNAFWCPSGVCIPRHAVRDGVRDC LGGEDELEENGPIVENDPKEFFTDPLAEIKKIRSTAESKLQCGVPNMDYVYKAEDDGSSR QRRKRLVGGEESLPTQIQWQVAIQDEGSIHCGGVYLGGCWVLTAAHCVRPKPKSFRVKFS LWRKNRKQSTTDSIPVKKIIIHENYDAQTYVNDIALVQLEELNLSDKCMLDNPAIRAVCV PWSTQQFQPNDTCTISGWGRDKAGMSASILKWANVTIIGDCQNFYKHRFLPGMECAGDLE GKVDSCQGDSGGPLVCKDASGLSYVWGIVSWGDKCGEPNHPGVYTKVAHYFDWIRFNTGW AAVTKFNQ >NP_031712.2 complement factor I isoform 1 preproprotein [Mus musculus] MKLAHLSLFLLALHLSSSRSPSASDLPQEELVDQKCLLQKYTHRSCNKVFCQPWQRCIEGTCICKLPYQC PRAGTPVCAMNGRSYPTYCHQKSFECLHPEIKFSHNGTCAAEGKFNVSLIYGRTKTEGLVQVKLVDQDER MFICKNSWSMAEANVACVDLGFPLGVRDIQGSFNISGNLHINDTECLHVHCRGVETSLAECAFTKRRTEL SNGLAGVVCYKQDADFPTSLSFQCVNGKHIPQEKACNGVNDCGDQSDELCCKGCRGNASLCKSGVCIPDQ YKCNGEVDCITGEDESRCEEDRQQNIPKGLARSAQGEAEIETEETEMLTPGMDNERKRIKSLLPKLSCGV KRNTHTRRKRVIGGKPANVGDYPWQVAIKDGQRITCGGIYIGGCWILTAAHCVRPSRAHSYQVWTALLDW LKPNSQLGIQTVKRVIVHEKYNGATFQNDIALIEMKMHTGKKECELPNSVPACVPWSPYLFQPNDRCIIS GWGRGKDNQKVYSLRWGEVDLIGNCSQFYPDRYYEKEMQCAGTRDGSIDACKGDSGGPLVCEDINNVTYV WGIVSWGENCGKPEFPGVYTRVANYFDWISYHVGRSLVSQHNV >NP_077071.1 complement factor I precursor [Rattus norvegicus] MKLALLILLLLNPHLSSSKNTPASGQPQEDLVEQKCLLKNYTHHSCDKVFCQPWQKCIEGTCACKLPYQC PKAGTPVCATNGRGYPTYCHLKSFECLHPEIKFSNNGTCTAEEKFNVSLIYGSTDTEGIVQVKLVDQDEK MFICKNSWSTVEANVACFDLGFPLGVRDIQGRFNIPVNHKINSTECLHVRCQGVETSLAECTFTKKSSKA PHGLAGVVCYTQDADFPTSQSFQCVNGKRIPQEKACDGVNDCGDQSDELCCKGCRGQAFLCKSGVCIPNQ RKCNGEVDCITGEDESGCEEDKKNKIHKGLARSDQGGETEIETEETEMLTPDMDTERKRIKSLLPKLSCG VKRNTHIRRKRVVGGKPAEMGDYPWQVAIKDGDRITCGGIYIGGCWILTAAHCVRPSRYRNYQVWTSLLD WLKPNSQLAVQGVSRVVVHEKYNGATYQNDIALVEMKKHPGKKECELINSVPACVPWSPYLFQPNDRCII SGWGREKDNQKVYSLRWGEVDLIGNCSRFYPGRYYEKEMQCAGTSDGSIDACKGDSGGPLVCKDVNNVTY VWGIVSWGENCGKPEFPGVYTRVASYFDWISYYVGRPLVSQYNV >NP_001258947.1 complement factor I precursor [Gallus gallus] MRVVAVLLVCFSLFSFCRAQNESSNDTEEQSSYVEPAQPVEQDSQPAERDTYLIEECLSNKYTHKSCKKV FCHPWERCVEGKCLCKLPYQCPKNGTSVCSTTGKNFYTYCHLKSFECQRSEAKFLNKGKCMSTETFKISL VYNDSHLLQVKPVNNEDLFVCDSMWTMNEANVACRHLGFELGAEYYHTIYNITEPSHCFQITCRGLETSL AECYIEKKLRASNEGFVSLQCQKTLRECSAGEFHCANDKCISVTKTCDGINDCGDLSDELCCKECRNNSF HCRSNICIPNKNVCNKEVDCLTGEDEAQALCSGKPKHEENHSMDAERKLAKTFLPQINCGVVNHTLTRRK RIIGGQTARKGEFPWQVAIKDTGTEGATVYCGGVYIGGCWVLTAAHCVRATRVHQYRVWIGLLDTIQYDR ETDTYRLKQLIIHEKYDAATYENDIALLELKGHGKGECSLKYSTPACVPWSEHMFKAGDKCKVSGWGLEK GYTKQYVLKWGNVNLFQNCSEMYPGRFFQKMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWG ENCGEAGHPGVYTQVASYYDWISHHVSRSLISRYNI >XP_003310493.1 complement factor I isoform X1 [Pan troglodytes] MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCICKLPYQCPKN GTAVCATNRRSFPTYCQQKSLECLRPGTKFLNNGTCTAEGKFSVSLKHGITDSEGIVEVKLVDQDKTMFI CKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDLA DVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKSFHCKSGVCIPSQYQCNG EVDCITGEDEVGCEAARHPTIQGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVG GKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTRVVDWIHPDRKRIVIEHV DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVF SLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGK PEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_005639325.1 complement factor I isoform X1 [Canis lupus familiaris] MKLVHVILLHLCFCLSFCKDTDENQKQWIRKTQLSSLSNTPQVSLLDEKCLTERYTHLSCNKVFCQPWQK CIDGTCTCKLPYQCPKDGTSVCSTNGRSYPTYCQQKSFECLRPGAKFLNNGTCTAEGQFSISLNYGNTTS EGIVEVKLIHQDKKMFICKKSWSILEANVACVDLGFQQGAFDIQKTFEVPEDQHKNLTECLQVHCRGLET SLAECTFTKRRAKSVAGVVCYTENTVSAASDSFHCVNGKQIPQKRTCNGINDCGDQSDELCCTGCHGKSF FCKSGVCIPNKYKCNGEVDCITGEDENGCQGTEHSEIKEETEYLTANMDAERKRIKSLLPKLFCGVTNNV LSRRKRVVGGKAAVMGDFPWQVAIKENEKIKCGGIYIGGCWILTAAHCVSVSRIYQYQIWTSFLSSLRPD NDTVVQLAKQIIVHENYSGATYENDIALIELRKRSNQKECSLPHSIPACVPWSSYLFQPNDRCTVSGWGR EKDNQKVYVLKWGDVKLIDNCSKFYPGRYFEKEMVCAGTDDGSIDACKGDSGGPLVCKDINNVTYVWGVV SWGENCGNPEYPGVYTKVANYFDWISHHVGRSLISQYNV >NP_001033185.1 complement factor I precursor [Bos taurus] MKLGHVILLLLCFYLSFCEDNFRKRGKSKAVKKSEAHHAPEASLSKETEASSEVKPTSTQDTSQKDFVDK KCLTEKHTHLSCNKVFCQPWQKCIDGTCLCKLPYQCPKNGTRVCSTNGKSYSTYCQQKSFECYRPEAKFL KSGACTGGGQFSVSLSNGKQDSEGIVAVKLADLDTKMFVCGDSWSITEANVACIDRGFQLGALDTHRRDP DPNSAECLHVRCRGLETSLAECTFTKGVHNSEGLAGVVCYTESAAPPKKDSFQCVNGKRIPQRKACDGVN DCVDKSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEETGHPEIKEAAEMLTADMDAE RKFTKSFLPKLSCGVKNNMHIRRKRVVGGKPAKMGEFPWQMAIKEGDKIHCGGIYIGGCWILTAAHCVRI SRMHRYQIWTSFTDWLRPGFQTVVHSVNRIIIHENYNGTTYQNDIALIEMKKRPNEKECVLSKSIPACVP WSPYLFQPNDKCIVSGWGREKDNQKVYSLRWGEVHLINNCSEFYPGRYFEKEMQCAGTDDGSIDACKGDS GGPLVCQDVNNVTYVWGVVSWGENCGKSEFPGVYTKVANYFDWISQHVGRSLISQHNI >XP_024101436.1 complement factor I isoform X1 [Pongo abelii] MKLLHVFLLFLCFHLSFCKVTYTSQEDLVEKKCLAKKHTHLSCNKVFCQPWQICIEGTCICKLPYQCPKN GTTVCATNGRSFPTYCQQKSLECLRPGTKFLNNGTCTAEGKFSVSLKHGNTDSEGIVEVKLVDQDKTMFI CKSSWSMREANVACLDLGFQQGADTQRRFKLSNLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDLA DVVCYTQKADSPTNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKSFHCKSGVCIPSQYRCNG EVDCITGEDEVGCEGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRRHIRRKRIVGGKRAQLGD LPWQVGIKDASGITCGGIYIGGCWILTAAHCLRASKTHHYQIWTTVVDWIHPDRKRIVIEYVDRIIFHEN YNAGTYQNDIALMEMKKDGNKKDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNEKVFSLQWGEVK LISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT KVANYFDWISYHVGRPFISQYNV >XP_002717177.2 PREDICTED: complement factor I isoform X1 [Oryctolagus cuniculus] MWLEKHLRQRQILNTSNMKLIHVLLSLLCFYLSFYRVTSTSNASPEDLVEKKCLMKKYTHLSCSKVFCQP WQKCIDGTCVCKLPYQCPKNGTSVCATNGKSYPSYCHQKSFECLHPGTKFLNNGKCTPEGKFNVSLKYGN TDSEGIVEVKLVEQDKSMFICKRSWSIREANVVCFDLGFQQGAVDVQGRFHFPENLHINSTECLNVRCQG LETSLAECTFTKRRNKGYQNLAGVVCFTQNAGSPKNESFQCVNGKNIPWKKACDGVNDCGDQSDELCCKG CQGESFLCKSGVCIPRQHICNDELDCITGEDEVGCEEADHRAVQDFLPVAQETTKILAVDMDAERRRIKS LLPKLSCGVRKNLQTRRKRIVGGKPAQVGQFPWQVAIKHDNRINCGGIYIGGCWVLTAAHCVSAHKAHQY QIWTGLLNWIIPNSELIVELVNKIIIHENYNGTTYQNDIALIEMKKRPNQKQCDLPNSVPACLPWSPYLF QPNERCIISGWGRDKDNQKVYSLSWGEVNLLSNCSKFYANRFYEKEMECAGTNDGSIDACKGDSGGPLVC KDINNVTYVWGIVSWGENCGKPEFPGVYTKVANYFDWISYHVGRSLIARYNI >XP_013844801.1 complement factor I [Sus scrofa] MVSNMKLAHVILLLLCFYLSFCKPTSGSDTSQEDLVEKKCLTEKYTHLSCDKVFCQPWQKCIDGTCICKL PYQCPKNGTSVCSTNGKSYPTYCQQKSFECLRPEAKFLKSGACTGEEQFSVSLDRGNGDSEGIVEVKLVD QDKKMYICAKSWSLTQANVACLDLGFKLGALYTQRRDPHINSPECLHVHCRGSETSLAECTFTKGTTSRS EGLAGVVCYTENAVSPTNDYFQCVNGKHISQKKTCDGINDCGDQSDELCCKGCRGESFFCKSGVCIPRKY KCNGEVDCITGEDEVGCEGSEHPEIKEETEMLTADMNAERKRIKSFFPKLSCGVKSSTHIRRKRVVGGQP AEVGDFPWQVAIKEGEKINCGGIYIGGCWILTAAHCVRASKAPRYQIWTSFTDWLNPDPQIVVQFVKQVI IHEKYNGTTYQNDIALIEMKKQPGRSECVLLKSVPACVPWSPHLFQPNDKCIVSGWGREKDNKKVYSLKW GEVHLISNCSKFYLNRFFEKEMVCAGTDDGSIDACKGDSGGPLVCTDANNMTYVWGVVSWGENCGKPEFP GVYTKVANYFDWISLHVGRPLISQHNV >XP_003205784.1 complement factor I [Meleagris gallopavo] MRVVAVFLLCFSFFSFCRAQNAASNDTEEFSYVEPAQPVEQDSQPAERDTYLLEDCLSNKYTHKSCKKVF CHPWERCVEGKCLCKLPYQCPKNGTSVCSTTGKQFHTYCHLKSYECQRPEAKFLNKGKCMSTETFKISLV YKDSHLLQVKPVNNEDLFVCDSMWTTNEANVACRHLGFELGAEYYHTDYNITEPSHCFQITCRGLETSLA ECYIEKKLRASNEGFVSLQCQKTLRECSASEFHCANDKCISVTKTCDGINDCGDLSDELCCKECRNNSFH CRSNICIPNKNVCNKEIDCLTGEDEAQALCSGKPKHEENLSMDAERKLAKTFLPQINCGVVNLTLTRRKR IIGGQIARKGEFPWQVAIKDTGTEGATVYCGGVYIGGCWVLTAAHCVRATRVHLYRVWIGLLDTIEYDKE TDTYRLKQLIIHEKYNAATYENDIALLELKGHGKGECSLKYSTPACIPWSEHMFKAGDKCKVSGWGLEKG YTKQYVLKWGNVNLFQNCSEMYPGRFLQKMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWGE NCGEAGHPGVYTQVASYYDWISHHVTRSLISRYNI >XP_003830061.1 complement factor I isoform X1 [Pan paniscus] MKLLHVFLLFLCFHLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCICKLPYQCPKN GTAVCATNRRSFPTYCQQKSLECLRPGTKFLNNGTCTAEGKFSVSLKHGITDSEGIVEVKLVDQDKTMFI CKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDLA DVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKSFHCKSGVCIPSQYQCNG EVDCITGEDEVGCEAARHPTIQGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRMHIRRKRIVG GKRAQLGDLPWQVAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTRVVDWIHPDRKRIVIEYV DRIIFHENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVF SLQWGEVKLISNCSKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGK PEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_006930977.2 complement factor I isoform X1 [Felis catus] MKLAHVILLFLCFYKSFCKDTDENQEQWTKKPQLPSTSYIPQKDLLDNKCLIEKYTHLSCKKVFCQPWQK CIDGTCICKLPYQCPKNGTSVCSTNGKSYLTYCQQKSFECLQPTAKFLNSGTCIAEGQFSVSLKYGTTTS EGIVEVKLVDQDKKMFICKKAWSIVEANVACLELGFQQGALEAQKSFEVPEDLHINSTECLHVHCRGLET SLAECTFIKRRTKNYQDLAGVVCYTQNTVSSANDSFRCVNGKYIPQKKTCNGVNDCGDQSDELCCKGCRG KSFLCKSGVCIPNKYKCNGELDCITGEDEIGCKGERRIDLTHVSGDDDHRPGHSEIKEETELLTANMDAE RKRIKSLLPKLSCGVKPIRPTRRKRVVGGKPAEVGDFPWQVAIKDNEKINCGGIYIGGCWILTAAHCVSV SKAHHYQIWTSFLHLLRPEEELVVQLANKIIIHENYNGSSYENDIALIEMKKHSKRKECVLPNSVPACVP WSPYLFQPNDRCIISGWGREKDNQKVYSLQWGEVKLLDNCSKFYPGRYFEKKMECAGTDDGSIDACKGDS GGPLVCQDINNVTYVWGVVSWGENCGKPEFPGIYTKVANYFDWISYHVGRSLISQYNI >XP_004009671.1 complement factor I [Ovis aries] MKLGHVILLLLCFYLSFCEDNFRKQGQSKAVKKSQAHHAPEASLSKETEASSEVKLTSTPDTSQKDFVDK KCLTEKHTHLSCNKVFCQPWQRCIDGTCLCKLPYQCPKNGTRVCSTNGKSYSTYCQQKSFECVRPEAKFL KSGACTGEGQFSVSLSNGKQDSEGLVAVQLADQDRKMFVCGDSWSITQANVACLDLGFQLGALDTHRRDP DLNSAECLHVRCRGLETSLAECTFTKGVHSSEGLAAMVCYTEEAAPPKKDSFQCVNGKRIPQKKACDGVN DCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEGTGHPEIKEAAEVLTADMDAE RKFIKSFLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQIAIKESDKIHCGGTYIGGCWILTAAHCVRI SRMHRYQLWTSFTDWIRPGFQTVVHSVNRIIIHENYNGTTYQNDIALIEMKKRPSEKQCVLSNSVPACVP WSPYLFQPNDKCIISGWGREKGNQKVYSLKWGEVHIINNCSAFYPGRYFEKEMECAGTDDGSIDACKGDS GGPLVCQDVNNVTYVWGIVSWGENCGKSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_018880871.1 complement factor I isoform X1 [Gorilla gorilla gorilla] MKLLHVFLLFLCFCLRFCKVTYTSQEDLVEKKCLAKKYTHLSCDKVFCQPWQRCIEGTCICKLPYQCPKN GTAVCATNRRSFPTYCQQKSLECLRPGTKFLNNGTCTAEGKFSVSLKHGITDSEGIVEVKLVDQDKTMFI CKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLHVHCRGLETSLAECTFTKRRTMGYQDLA DVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKSFHCKSGVCIPSQYQCNG EVDCITGEDEVGCEGFASVAQEETEILTADMDAERRRIKSLLPKLSCGVKNRTHIRRKRIVGGKRAQLGD LPWQMAIKDASGITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDRKRIVIEYVDRIIFHEN YNAGTYQNDIALIEMKKDGNKKDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVFSLRWGEVK LISNCSKFYGNRFYEKEMECAGTHDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYT KVANYFDWISYHVGRPFISQYNV >XP_004079594.1 complement factor I [Oryzias latipes] MSTRRISSSLLLLFLLILCSGASNPADKEEPSSIGQQMNQEHLKPRLPKPRPSPVTTSPAPAAPATPAPP QTDEFLGPLECLDKKLTRASCGRVFCSPWQRCIDGVCSCKPPYMCPRDGVKAVCTRNHKRYLSYCQAMAM SCTTKKAVLSHFGEVCGESVKKFSSSIDKQTGVVKLFLPDDGVGEELLVCHGQWNMAAANVACREEHNHP GLESMGAASAFAVNYSQISGGAEPLPRRCVNVRCQGFEFSLAECEIYNRVDIGDGAVAAARCYDSRPPED CGFTCANDKCVSLNQTCDGVDDCGDRSDEMCCKKCRNRAFRCNTGVCVHPDAVGDHQLDCLGGEDETPKH LNTIARTTKQEAEPPEYVSRRNETKTTRHLLESNLVCGIPNMDLVDETEEHVRGRISRKKRVVGGVEAKP TQIQWQVALQEHGRIDCGGAYVGGCWVITAAHCVRRNPAAFKVKFSLWKKYAPQGSTDIVPVEEIIIHPN YNPATYENDIALVKLKKYPYRDYCVEENPAIRAVCVPWSIELFQPNYTCSISGWGRTKTGKSAEVLLWAN VSLIEGCQSSYKHRFKAGMMCAGDLDGNVDSCQGDSGGPLVCQDQLGVSYLWGIVSWGDKCGKRGYPGVY TQVAYFFEWIRSHTGWPAVTKFNS >XP_005515274.1 complement factor I [Columba livia] MTVVPVFLVFLSLFWFCGSEHASSNAKENQFQQVEPTQPAEQDPYLIKECLSNQYTHKSCEKVFCHPWER CVEGKCLCKLPYQCPKNGSSVCSANGKYFHTYCQLKSYECQRPEAKFLHKGKCASKETFAISVDHGDSHL LRVKPVNQKNAMFVCGSEWTMNEANVACRHLGFESGAEHYQANSSITESALNSLHCLQITCRGLETSLAE CHIQVKSRDSNEGFVSLQCHENLRVCSAGEFHCVNKKCISLTKTCDGINDCGDLSDELCCRECRDNSFHC RSNICIPNKNVCNKEIDCLTGEDEARVLCAGKHKGAENHSMDKERKRIKTFLPKVHCGLTNHTLTRRKRI VGGETARKGEFPWQVAITEAGSDGATLYCGGVYIGGCWVLTAAHCVRANRIHLYRVWVGLLDTIEYDKGT HTYTLKQLIIHEKYNASSYENDIALLELSGKGECSLAQSTPACVPWSQYMFRPGDTCKVSGWGLEKGYTK QYILKWGNVNLFQNCSELYPGRFFEQMACAGTYDGSVDSCKGDSGGPLVCFDADNVAYVWGIVSWGENCG EAGHPGVYTKVASYYDWISHHVTRSLISRYNI >XP_005681373.2 PREDICTED: complement factor I [Capra hircus] MKLGHVSLLLVCFYLSFCEDNFRKQGQSKAVKKSEAHHAPEASLSKETEASSEVKLTSTPDTSQKDFVDK KCLIEKHTHLSCNKVFCQPWQRCIDGTCLCKLPYQCPKNGTRVCSTNGKSYSTYCQQKSFECVRPEAKFL KSGACTGEGQFSVSLSNGKQDSEGLVAVQLADQDRKMFVCGDSWSITQANVACLDLGFQLGALDTHRRDP DLNSAECLHVRCRGLETSLAECTFTKGVHNSEGLAAMVCYTEEAAPPKKDSFQCVNGKRIPQKKACDGVN DCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEGTGHPEIKEAAEVLTADMDAE RKFIKSFLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQIAIKESDKIHCGGTYIGGCWILTAAHCVRI SRTHRYQLWTSFTDWIRPGFQTVVHSVNQIIIHENYNGTTYQNDIALIEMKKRPSEKQCVLSNSVPACVP WSPYLFQPNDKCIISGWGREKGNQKVYSLKWGEVHIINNCSAFYPGRYFEKEMECAGTDDGSIDACKGDS GGPLVCQDVNNVTYVWGVVSWGENCGKSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_025062148.1 LOW QUALITY PROTEIN: complement factor I [Alligator sinensis] MKVLLLLGFSCVFFCTYGGKVFQNQTSEYNXXXXXXXXXXXQQVQPSHKETHLVGECLKEKYTQDSCEKV FCLPWKRCVSGNCICKLPYQCPKNGTSVSSINGKTFRTYCQLKSYECQRPEAKYMSKGDYIHGEKFDVSL NYGDSESEGVIQVKLVNNTEKLFLCNSKWSMNEANVACRHRGFETGAEYHRKTFTVPEHNNTSSCCLQVI CRGVETSLAECKLIKRSPPGGVKNFATVACHKVQRECTPQEFCCANKKCIPLTETCNGINDCGDLSDELC CKECKIKSFLCNSGVCIPKKYLCNKEIDCLTGEDELQVNCEDEQNVELETQDQDDEGQNPETETQGQQSG NKEADHKVIIRTRAKGKAQEVIPNYNADEERRAIKTFLPELKCGITNHTVTRRKRIVGGNPAAKGEFPWQ VAIKEEGGTGPSVYCGGVYIGGCWILTAAHCVRATRVHQYRIWSGLLDTIQYNREIDTFKLNKVIIHEKY NAGTYENDIALLEMKSMDKGKPCSLAYSTPACVPWSEYMFKPGHRCKISGWGLERDSAKQFVLKWGYIDI LSNCTEIYKDRFFKGMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCGVAGYPGVYTKV ASYFDWISHQVGRALISKYNV >XP_014453781.1 PREDICTED: complement factor I isoform X1 [Alligator mississippiensis] MKLLLLLGFSCVFFCTYGGKVFQNQTSEYNKEPVQQVQPTHKETHLVGECLKEKYTQDSCEKVFCLPWKR CVSGNCICKLPYQCPKNGTSVSSINGKTFRTYCQLKSYECQRPEAKYMSKGDCIHGEKFDVSLNYGDSES EGVIQVKLVNNTEKLFLCNSKWSMNEANVACRHRGFEAGAEYHRKTFTVPEHNNTSSWCLQVICRGEETS LAECKLIKRSPPGGVKNFATVACHKFQRECTPQEYCCANKKCIPLTETCNGINDCGDLSDELCCKECKNK SFLCNSGVCIPKKYLCNKEVDCLTGEDELQVNCEDEQNVELETQDQDDEGQNPETETQGQQSGEQSPEPD VQGQYFGNKEADHKVIIRTRAKGKAQEVIPNYNADEERRAIKTFLPELKCGITNHTVTRCKRIVGGNPAA KGEFPWQVAIKEEGGTGPSVYCGGVYIGGCWILTAAHCVRATRVHQYRIWSGLLDTIQYNREIDTFKLNK VIIHEKYNAGTYENDIALLEMKSMDKGKPCSLAYSTPACVPWSEYMFKPGHRCKISGWGLERDSAKQFVL KWGYIDILSNCTEIYKDRFFKGMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCGVAGY PGVYTKVASYFDWISHQVGRALISKYNV >XP_015831712.1 PREDICTED: complement factor I [Nothobranchius furzeri] MRRQSLFLLLLLLFCSETLAGKQKPKRKTTTTAPKPAATTPAATTPPATTPPATTPAATTPAATTPAATT PAATTPAATTPAALTTKAPHTDEYLGECQNKRLTRDSCGLAFCLPWQRCIDGQCTCKPPYQCPMEGMKPV CGNNNRNYRSFCQAMALSCRTKKPLFSHFGEQCNANVKKFESSLDNETGVVRIFLPGSTGQGEWLLVCQD MWDMAAANVACREKSHSLGAASAEARVYNDLMVNSEITNLPGSCVSIRCQGYETSLAECEIYDKVDAVDM MVAAATCYISAECGFTCENTKCISLNQTCDGVDDCGDRSDEMCCKKCRNGAFHCKTGICVHKDGVGDNQL DCLDGADEAVKHTTAASNDANQARGPTAYVSRKNETRTNRMILESQLHCGIPNKTFEGSENSHDRGHSSR RKRVVGGAEARPTQIQWQVALEENQRIDCGGAYIGGCWVITAAHCVRPRPSAFRVKFSLWKKFRAQGTTD IVPVEEIRIHPNYVASTYENDIALVKLEKLPFTDKCLLDNPAIRPVCVPWSTHLFQPNHTCSISGWGRNK EGKAAQVLLWANVSLIAGCESSYKDRFKPGMICAGDVDGHVDSCQGDSGGPLVCEDELGVSYLWGIVSWG EKCGQPGFPGVYTQVAHYFEWIRLHTGWPAVTRFNS >XP_020743606.1 complement factor I [Odocoileus virginianus texanus] MAPDKPLRPADGEAQGEGGLEWTGRRQRLRSNCGPEITAGAGATDPSPPQPPSPKLSLRKRPTAYSGKRK SKAVKKSEPASTPGTSQKDFVDKKCLTAKYTHLSCEKVFCQPWQKCVDGTCLCKLPYQCPKNGTRVCSTN GKSYPTYCQQKSFECFRPEAKFLKSGACTGEGQFSVSLSNGKRDSEGVVAVKLADQDRKIFVCGDSWSIT QANVACLDLGFPLGALDTHRRDPDLNSAECLHVHCRGLETSLAECTFTKGVINILKGLAGMACYTESAAP PEKDSFQCVNGKRIPQKKACDGVNDCVDNSDEMCCKDCQGEGFLCKSGVCIPKQYKCNGELDCITGEDEV GCEGTRHLEIKEEAEMLTADMDAERKFAKSLLPKLSCGVKNSMHIRRKRVVGGKPAKMGDFPWQVAIKED DKIHCGGIYIGGCWILTAAHCVRVSRIHRYQLWTSFTDWLKPDSEIVVQFVNQIIIHENYNGTTYQNDIA LIEMKKRPNQKECVLSKSIPACVPWSPYLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNCSKFYPG RYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISL HVGRALISQHNV >XP_030287044.1 complement factor I-like [Sparus aurata] MRSAGVSLFLLFLLIAYSEMETTPTTQPTTMVNSSAPTIPGTNETDKFFGPQECWDKKLTRASCDLVFCP PWERCIRGHCSCKTPYLCPAVVNGVPVCGRDNRNYRSFCQVMAVSCRTRKPVMSHFGLNCGDNQPKFNTS IDPETRVVKVFVPDARSPNGGEELLVCGKTWNMAAANVACKEKGTPLGAMAAHRIEHNNPTATNFPSSCV NVRCQGYETSLAECVIYDKVRIATKNLATATCYEAPSDTACGFTCVNGKCVSLEQTCDGVDDCGDGSDEM CCKACRKGAFLCKTGVCVPKDALHDKQIDCLDGKDESPKHTLDNMREPVPQQLRNSDYISSKDETAKTRE HLESRLECGIPNMDIVDDEVFEERGRSSRTKRVVGGIPSKPTQIQWQIALGDKGKIDCGGAYIGGCWVLT AAHCVRPNPSAFMVYFSMWKKSSAQGTTDIVLVKNIQIHPKYNASSYENDIALVQLEKLPFSDKCLEDNP AVRAVCVPWSTELFRTNHTCSISGWGRTAEGKRSRVLLWANVSLIDNCGNFYGHRFNKDSMLCAGDLEGK VDSCQGDDGGPLVCEDELGVSYLWGIVSWGEKCGQPGFPGVYTQVAHYFEWIRLHTGWPAVTKFNS >XP_040185110.1 complement factor I [Rana temporaria] MKTSSLVWFLLSLACVCIATDTYTQKECLTEKHTYNSCQKVFCDPWKRCVDGKCICKPPYQCPKNKTMGV CTESQRTFLTYCQLKSAECSNAAYRFASNSPCKGKFEISVKKRNGNIVKNNGTVLIKLPGDTKEFPVCPA KWTITEANVACKQLGFPQGALSEPLKASFKEDVQGQHTECLHVTCRGTETSMAECIMKKDTVSENLWAAV NCYKEKRDCTDDEFTCVNEKCIPAEHACNGDDNCGDRSDELCCSDCRNSFHCSSDICIPKHYVCNGQMDC LKGEDEAKCKVEGSEGEGSENRENNEGKDHNLKGERSENNNDDVEPQVPQDKKTDLVNAVNFDIEAEIKL IKESISSVSCGIPVKQPDIKRFKRIIGGTKAKENQFPWQVAIKDGAKVNCGGIYIGGCWVLTAAHCVRAD QPHKYRVIIELLDRLSVSENVDSFPVKTVKVHENYKSGTYENDIALLEVVNIYKEPACMQVDNNLVPACV PWSTHLFKTGDTCVVSGWGREEGFTKVFHLKWGNINLMNNCTSIYKDRFLNGMECAGTYDGSIDACKGDS GGPLICYDANNVAYVWGVVSWGENCGVAGFPGVYSKVAYYFEWISRHVGRALISKYNI >XP_043727043.1 complement factor I isoform X2 [Cervus elaphus] MKLGHVILLLLCFYLSFCEVTFGKRKSKAVKKSEPASTPGTSQKDFVDEKCLTAKYTHLSCKKVFCQPWQKCVDGTCLCK LPYQCPKNGTRVCSTNGKSYQTYCQQKSFECFRPEAKFLKSGACTGEEQFSVSLSNGKQDSEGVVAVKLADQDRKMFVCG DSWSITQANVACLDLGFPLGALDTHGRDPDLNSAECLHVHCRGLETSLAECTFTKGVINILNGLAGMECYTESAAPPKKD SFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEENRSKSLSQGT RLLEIKEEAEMLTADMDAERKFTKSLLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQVAIKEGDKIHCGGIYIGGCWI LTAAHCVRVSRIHRYQLWTSFTDWLKPDTDIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRPNQKECVLSKSVPACVPW SPHLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNCSKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNN VTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >XP_043294407.1 complement factor I isoform X2 [Cervus canadensis] MKLGHVILLLLCFYLSFCEATFGKRKSKAVKKSEPASTPGTSQKDFVDEKCLTAKYTHLSCKKVFCQPWQKCVDGTCLCK LPYQCPKNGTRVCSTNGKSYQTYCQQKSFECFRPEAKFLKSGACTGEAQFSVSLSNGKQDSEGVVAVKLADQDRKMFVCG DSWSITQANVACLDLGFPLGALDTHGRDPDLNSAECLHVHCRGLETSLAECTFTKGVINILNGLAGMECYTESAAPPKKD SFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEENRSKSLSQGT RRLEIKEEAEMLTADMDAERKFTKSLLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQVAIKEGDKIHCGGIYIGGCWI LTAAHCVRVSRIHRYQLWTSFTDWLKPDTDIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRPNQKECVLSKSVPACVPW SPHLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNCSKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNN VTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0368187.1 hypothetical protein FD755_019953 [Muntiacus reevesi] MVFQLVCCFYVRERGRETCCLIPHHPLTLSLSLKCTVFTVRPASTPDTSQKDFVDKKCLTAKYTHLSCEKVFCQPWQKCV DGTCLCKLPYQCPKNGTRVCSTNGKSYPTYCQQKSFECFRPEAKFLKSGACTVEGQFSVSLSHGKQDSEGVVAVRLADQD RKMFVCGDSWSITQANVACLDLGFPLGALDTHGRDPDLNSAECLHVHCRGSETSLAECTFTKGVINILKGLAGMECYTES AAPPEKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEGTRH LEIKEEAEMLTADMDAERKFAKSLLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQVAIKEGDKIHCGGIYIGGCWILT AAHCVRISRIHRYQLWTSFTDWLKPDTEIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRPNQKECVLSKSVPACVPWSP YLFQPNDKCIVSGWGREKGNQKVYSLMWGEVHLINNCSKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVT YVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0342649.1 hypothetical protein FD754_019575 [Muntiacus muntjak] MDRGTWRATSEQRKRKIQSKLTRGSYHHKPGAHQEGLMCITLPPASTPDTSQKDFVDKKCLTAKYTHLSCEKVFCQPWQK CVDGTCLCKLPYQCPKNGTRVCSTNGKSYPTYCQQKSFECFRPEAKFLKSGACTGEGQFSVSLSNGKRDSEGVVAVRLAD QDRKMFVCGDSWSITQANVACLDLGFPLGALDTHGRDPDLNSAECLHVRCRGSETSLAECTFTKGVINILKGLAGMECYT ESAAPPEKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDCRGEGFLCKSGVCIPKQYKCNGELDCITGEDEVGCEGT RHLEIKEEAEMLTADMDAERKFAKSLLPKLSCGVKNNMHIRRKRVVGGKPAKMGDFPWQVAIKEGDKIHCGGIYIGGCWI LTAAHCVRISRIHRYQLWTSFTDWLKPDTEIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRPNQKECVLSKSVPACVPW SPYLFQPNDKCIVSGWGREKGNQKVYSLMWGEVHLINNCSKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNN VTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >NP_001079421.1 complement factor I S homeolog precursor [Xenopus laevis] MNKLSCVFILLFHFWVNTFTITVSGAEEAKPDKCEFNALSCHKIFCAPWQKCLAGVCRCKLPYQCPKNATTEVCTVGKRK LQSYCQLKSVECPNPLNGKYRFSSEAPCTDAFSIRLIGEAGKGIIKVKLPTFEKEFFICKKQWSIREANVFCKQLGFPSG ADASASDKVVPLITEESPEEHCLQATCRGLENSLAECALKKLPMEGNQVAEVKCYTEKKDCGSGEFTCSNGKCIPSDLAC DSENDCGDLSDELCCRGCTAGFHCKSDTCIPEQYRCNGELDCIGGEDESNCAVKQEQKSEKQEEVKQEQRSEKQEEGVNQ ELKATQEEERRLLMKSLPELSCGVPPVTSTLTRKKRVIGGTNAVKNQFPWQVAIKDGTSVNCGGIYIGGCWVLTAAHCVR ANQPQRYLIILELLDRLSYDKDIDSFPVKSVLVHESYNPNTYENDIALLEVKNIYNNPKCMQTDNNMVPACVPWSPFQFR TGDTCTVSGWGREKGMSRVFHLKWGHINLMNNCTEVYKERFLDKMECAGTYDGSIDACKGDSGGPLVCYDVNKVAYVWGI VSWGENCGVPGFPGVYTKVAHYFEWISRHVGRSLISKYNV >XP_039258771.1 transmembrane protease serine 6-like [Styela clava] MSNLFEDDSFLLVFRGVNVRTRKYVGYYSGNKSGSVYRSRYHQISIVFTSDESTTRSGFNISYKTGTPQTLKACPGNSYI VALGMESGEIKDGQISASSAFSQQWKPSLSRLNNRRGAWISAKAVLPRHRSYKLPTTQNQWIQIDLLRNRVVTGIVTQGF ILTSGDLFVTSFSILFRKSRKTWREYREGIDPRLKVFKANIDGRTSCNIQFSHPFAARYLRIIPRSWTGQYIVMRMEILG CSGSTSLANDDECGEDDFECGDGTCISRELICDKNNDCDDKSDEVDCAKCRNFQFKCGSGECILRKKRCDGSKDCSDATD EMGCSRCHGDDFQCHDESMCLKIKRVCDEYKDCDDFSDERNCSHPWLCPVHTDYKCSDRSCVPGINLKCNGFTDCDDSSD ENDCDCGTSPKFDSNVILDETLVSSTNSRSRRSVTNSGRFPRIVGGMDADIESWPWQVSIEKSKDKEHFCGGALISNRFI LTAAHCLVAKKKADIRIKMGLNHLTETENTQSFNASRVFMHPRYDAQTYDFDIALIKIDGNATLSDRTRKICLPPSSHIF HEGQSCWITGWGTTSVRGRRSETLQEARVELMTNDQCNRPRWYAGKITPRMICAGDSNGSVDSCQGDSGGPLVCQERGGK WFVAGIVSWGNGCGVAYKPGVYTRMTEMIHWVEDIMEKEDGDG >XP_038060987.1 uncharacterized protein LOC119731787 isoform X3 [Patiria miniata] MRAIRLLGFTIALFLLLEVDHVFSKELGLKSRSKIKEKKLHPPKRVDKVYYVSNRHRRDSGSSDEGDDEDEEETGEGDYR AQYGKPNAPNTHKNTGGAPQAETEYSIRLVNGRNEYEGRVEVKKDASSRWGLVCDDYWGMEEATVVCRQLGYGDPVEAVS NALNRFSGSIGKKQYVMDDIQCRGTEDALQLCQFAGWGVTNCISDIEVAGIVCSPPNMDPDANPESPECFTDSRGADYRG FVSTTVSGKTCQKWTVQTPHTHRHTPDRFPDDGLGDHNYCRTVSEVNAERPWCYTVSAARREYCDVGLPQVSCNRQAVAE QRTNPMEHFALFQNAAIPGANMEEHHGVTAEQCAELCLATTSFSCRSFDHYRDDNRCWLSDKSSHSSDLKFDFNNNPFDY YERIDIGTLSQFEIIPNAAIAGHNEEEHQGVSMQRCAQLCVLATFGCASFDYARRTSQCWLSRATTETANLRTDIEAQPF DYFQRNGGAMPDCYRGNGHSYRGSYSATETGKDCVPWTFAAARGAGVNNAQYPNTGVGNHNHCRNPDNDQQPWCYFADAS GQLEGWTYCGLPACQLTGPAESETPTTTQAPGGLRLLSQGKETVQSSTLTLTGVAREASLAVDGNASPHFDDNSCTLTDS ERHPWWYVDLGREYEIDHIVIVNRYDNGNRLKRATVRVGDAILNVDSFLECGQVTGAMIKNAAKREHRQITIQCSAETVG RYVYIEQTRNQALHLTLCEVEVYGQDVTATGPPPSISCSSEQFACVTGGIHCIPNSWVCDQDPDCEDGTDEQGCNDPLAD FNPLADSAIPSSINPDVTYMDKTLAECAQFCVTNMDIVCRSFEYEAATRDCSLFDENRAQTGGLEARPGVTHYERLSQTT DCSNVDGELYHPCPSGRCVPTRWLCDGDNDCGDFSDERQCSVEGPTQEPSSEFAIRIVNDQLGQTSTNEYQGRVEVQYMG VWGTVCDDNWDIQDATVVCKQLGFTRGAVSAVIVGEFGQGNGNIIMDDVECAGTEMSLADCPFSGWGVHNCVAREAAGVI CIPNEGCLDSQFECGNGDCIPLNWKCDGTDDCGDNSDEQQCQSADLPVRLVGGPDANSGRIEVMFAGQWGTVCDDRFDDN AAQVVCRQLGITGNSRVFEKAHFGQGQGQIWLDEVQCQGGENHLGECGHSRFGSNDCSHGEDVGVECGIVPVPEVTMAPG SCGVKQVDNGINARIIGGTAAKKGSWPWQAQLLLRQSGHYCGATLIDEFHVLTAAHCFQRYGKDRFKVRLGEHDQYRSEN SEQDFDIECLHLHEDYSSSTTNNDIALIKLKPKNGRGAQMNTHVSPACLTGRDDLPDNHQCWISGWGNTGNDYPRLLQEA RVPLLPRSTCTGRRVYGSKLTSRMLCAGYLGGGIDSCDGDSGGPLVCEYQGTWQIIGVTSWGSGCAQPNAPGVYSRVNQF LDWINTKRQTAQC >XP_030835556.1 uncharacterized protein LOC578177 isoform X1 [Strongylocentrotus purpuratus] MGSLKFVCLCLGALMCVSTLMTHVDAKLKAKKIHAPSYASKVDLVQVTEEGRHRERRDDDDDDDEDIDSDIDPVIAELNR LLAEIRTIQDGAQVDTQGQNRAASSHRHPVRLQGGTSEYDGRVEINYEDQWYMVCDDYWGIEEATVVCNQLGFNGALEAV QRAADEYGFNDNGFAMDDVRCTGMEPGLSECDFPEWRSHNCDKGEEVAGVRCQPERTSPNRAIRSVQGAPTIPDSSQIML RFNVNELPPWLQSILGSKPSETSTPGSATGGTVAGSSGATGSDGSSQVPVTRARDPECFTMSNGQDYRGVVRQTISGYAC QRWNVQTPHGHSYTPAQYPGILGNHNHCRNPGTFSQPWCYTTNPRIIREYCDVGNPRTSCATTAQTVQGNGEATTYLSEY ALVPAAYLGGNNDGTHSVATAELCAERCNKERSFVCRSFEYNEQSNECLTSSSNSRDVDLTFLLSTRFNYYERLDIGPIA LFDITPNSAMPGNNIESLTAVSMEECAERCLVAAWPCASFDFARRANRCWLSNKSPSQVSIRSDFPDNPYDFFSRRGPAT PNCYLGTGENYRGFSFTTTQGHQCTNWQAAAMDNVGVTPVLFPDGDIGNHNFCRNPDSDRRPWCYYKDSGSSTVSGWMYC NISTCETSTAPPTSRPTARPPPPTQAPSGPIPVSRGKPAFQSSTHTSGGIMANAGLAVDGNPNPSFDQGSCSRTQSRANS WWYIDLEAAYDVTTVVIVNKDVQGERLRGAMVTIGSSATDPSTRTQCGRITRTMTNAASRTPHQRIRIDCPSPIRGQYVH IGSPRKDYLSFCEVEVYGRPSSPPTPAPEPTVSCTAAEFECASGSVSCVPERFQCNGQSDCTDGSDETGCPDPMDDFTII ADKYLPNREPAVIYMEKTADECARFCVSAMTFVCRSFDYNSAERTCSLFNVSRSQNGRLFSRQGTAHYERISQTTDCTNA NGIEYHPCPSGRCIPNEWLCDGDNDCGDFTDESNCGTLEEFEVRIVNGTAPNEGRVEVKYRGKWGLVCDDEWDLSDGHVV CRQLGYTRGASDVYIVGEFGHGNLVDIFMDDVRCTGNEQSLADCPHPGWGVNNCVVGEAAGVLCKLNQDCPANHFECNNL KCIPEGNVCNDMDNCNDGSDELNCQPELPVLPVRLVGGNGRTSGRVEVFHNNQWGTVCDDYFSEAAARVVCNQLGISGDV QVYPQAIFGEGTTQIWLDDVTCAGTEPSLAQCTIPNGIGRHNCQHNEDVGVECGRETLPCGVRGIENGNIMARIIGGSSA KRGNWPWQAQLILRGSGHYCGGTLIDETHVLTAAHCFQRYGKNSFKVRLGEHHQHINESSEQDFRISCIYKHPDYDSRTT NNDIAVLRLDRPAHITSFVTPACLPTDGEFAADHQCWISGWGNTGNDNYPSRLQEARVPLLPRSTCTRQNVYGNKLTPQM LCAGYLRGGIDSCDGDSGGPLVCENSNSVWKVVGVTSWGYGCAQPNAPGVYAVVTRYLGFINEKMITRTCT
Mafft alignment of selected proteins >sp|P05156|CFAI_HUMAN Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2 -----------------MKLLHVF---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLR-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTYTSQEDLVEKKCLAKKYTHL--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QRCIEGTCVCKLP------ --------------YQCPK------------------------------NGT-------A VCATNRRS---------------------------------------------------- ----------------------------------------FPTYCQQKSL---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------HPGTKFLNNGTCTA-------EG KFSVSLKHGN----TDSE--GIVEVKLV-----DQDKTMFICKSSWSMREANVACLDLGF -----QQGA-DTQRRFKL-----SDLSINSTECLHVHCRGLETSLAECTFTK--RRTMG- YQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKA------- ------------------------CQG--KGFHCKSGVCIPSQYQCNG------------ --------EVDCITGEDEVG--CA------------------------------------ -----------------------------------GFASVTQEETEI------------L TADMDAERRRIKSLLPKL-------------------SCGV--KNRMH------------ -----------IRRKRIVGGKRAQLGDLPWQVAIKD----ASGITCGGIYIGGCWILTAA HCLRASKTHRYQIWTTVVDWIHPDLKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG NKKDCELP--RSIPACVPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLISN-- CS--KFYGNRF-YEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISYHVGRPFISQYNV >tr|A0A0G2L5F9|A0A0G2L5F9_DANRE Complement factor I OS=Danio rerio OX=7955 GN=cfi PE=1 SV=2 -----------------MQ----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------Y--------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------VELEGEDWPDQCMKVRCTGSELSLAECTIYN--PTPIKE KQQVAVANCYNETTKE-QSMKFRCVNGKYVNYGKLCDGIDDCGDNSDEMCCQD------- ------------------------CQKKTNAFWCPSGVCIPRHAVRDG------------ --------VRDCLGGEDELE--EN----------------GP------------------ --------------------------------------IVENDPKEF------------F TDPLAEIKKIRSTAESKL-------------------QCGV--PNMDY--------VYKA EDDGSSR----QRRKRLVGGEESLPTQIQWQVAIQD----EGSIHCGGVYLGGCWVLTAA HCVRP-KPKSFRVKFSLWRKNRKQ-STTDSIPVKKIIIHENYDAQTYVNDIALVQLEELN LSDKCMLDNPAIRAVCVPWSTQQFQPNDTCTISGWGRDK-AGMSASILKWANVTIIGD-- CQ--NFYKHRF-LP-GMECAGDLEGKVDSCQGDSGGPLVCKDASGLSYVWGIVSWGDKCG EPNHPGVYTKVAHYFDWIRFNTGWAAVTKFNQ >NP_031712.2 complement factor I isoform 1 preproprotein [Mus musculus] -----------------MKLAHLS---------------------LFLLAL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLS-------------------------------SS----------R-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------S---------PSASDLPQEELVDQKCLLQKYTHR--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QRCIEGTCICKLP------ --------------YQCPR------------------------------AGT-------P VCAMNGRS---------------------------------------------------- ----------------------------------------YPTYCHQKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------HPEIKFSHNGTCAA-------EG KFNVSLIYGR----TKTE--GLVQVKLV-----DQDERMFICKNSWSMAEANVACVDLGF -----PLGVRDIQGSFNI----SGNLHINDTECLHVHCRGVETSLAECAFTK--RRTEL- SNGLAGVVCYKQDADFPTSLSFQCVNGKHIPQEKACNGVNDCGDQSDELCCKG------- ------------------------CRG--NASLCKSGVCIPDQYKCNG------------ --------EVDCITGEDESR--CE----------------EDRQQNIP--KGLARSAQ-- -----------------------------------GEAEIETEETEM------------L TPGMDNERKRIKSLLPKL-------------------SCGV--KRNTH------------ -----------TRRKRVIGGKPANVGDYPWQVAIKD----GQRITCGGIYIGGCWILTAA HCVRPSRAHSYQVWTALLDWLKPN-SQLGIQTVKRVIVHEKYNGATFQNDIALIEMKMHT GKKECELP--NSVPACVPWSPYLFQPNDRCIISGWGRGK-DNQKVYSLRWGEVDLIGN-- CS--QFYPDRY-YEKEMQCAGTRDGSIDACKGDSGGPLVCEDINNVTYVWGIVSWGENCG KPEFPGVYTRVANYFDWISYHVGRSLVSQHNV >NP_077071.1 complement factor I precursor [Rattus norvegicus] -----------------MKLALLI---------------------LLLLNP--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLS-------------------------------SS----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------N---------TPASGQPQEDLVEQKCLLKNYTHH--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QKCIEGTCACKLP------ --------------YQCPK------------------------------AGT-------P VCATNGRG---------------------------------------------------- ----------------------------------------YPTYCHLKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------HPEIKFSNNGTCTA-------EE KFNVSLIYGS----TDTE--GIVQVKLV-----DQDEKMFICKNSWSTVEANVACFDLGF -----PLGVRDIQGRFNI----PVNHKINSTECLHVRCQGVETSLAECTFTK--KSSKA- PHGLAGVVCYTQDADFPTSQSFQCVNGKRIPQEKACDGVNDCGDQSDELCCKG------- ------------------------CRG--QAFLCKSGVCIPNQRKCNG------------ --------EVDCITGEDESG--CE----------------EDKKNKIH--KGLARSDQG- -----------------------------------GETEIETEETEM------------L TPDMDTERKRIKSLLPKL-------------------SCGV--KRNTH------------ -----------IRRKRVVGGKPAEMGDYPWQVAIKD----GDRITCGGIYIGGCWILTAA HCVRPSRYRNYQVWTSLLDWLKPN-SQLAVQGVSRVVVHEKYNGATYQNDIALVEMKKHP GKKECELI--NSVPACVPWSPYLFQPNDRCIISGWGREK-DNQKVYSLRWGEVDLIGN-- CS--RFYPGRY-YEKEMQCAGTSDGSIDACKGDSGGPLVCKDVNNVTYVWGIVSWGENCG KPEFPGVYTRVASYFDWISYYVGRPLVSQYNV >NP_001258947.1 complement factor I precursor [Gallus gallus] -----------------MRVVA-----------------------VLLVCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLFS-------------------------------FC----------RA------- ------------------------QNESSNDTEEQSSYVEP------------------- ------------------------------------------------------------ -------------AQPVE---------QDSQPAERDTYLIEECLSNKYTHK--------- ---------------------------SC------------------------------- --------------KKVFC-------HPW------------ERCVEGKCLCKLP------ --------------YQCPK------------------------------NGT-------S VCSTTGKN---------------------------------------------------- ----------------------------------------FYTYCHLKSF---------- ------------------------------------------------------------ --------------ECQ------------------------------------------- -------------------------------------RSEAKFLNKGKCMS-------TE TFKISLVYND----S-----HLLQVKPV-----NN-EDLFVCDSMWTMNEANVACRHLGF -----ELGAEYYHTIYNI-----TE----PSHCFQITCRGLETSLAECYIEK--KLRAS- NEGFVSLQCQKTLREC-SAGEFHCANDKCISVTKTCDGINDCGDLSDELCCKE------- ------------------------CRN--NSFHCRSNICIPNKNVCNK------------ --------EVDCLTGEDEAQALCS------------------------------------ --------------------------------------GKPKHEE--------------- NHSMDAERKLAKTFLPQI-------------------NCGV--VNHTL------------ -----------TRRKRIIGGQTARKGEFPWQVAIKDTGTEGATVYCGGVYIGGCWVLTAA HCVRATRVHQYRVWIGLLDTIQYD-RETDTYRLKQLIIHEKYDAATYENDIALLELKGH- GKGECSLK--YSTPACVPWSEHMFKAGDKCKVSGWGLEK-GYTKQYVLKWGNVNLFQN-- CS--EMYPGRF-FQ-KMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWGENCG EAGHPGVYTQVASYYDWISHHVSRSLISRYNI >XP_003310493.1 complement factor I isoform X1 [Pan troglodytes] -----------------MKLLHVF---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLR-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTYTSQEDLVEKKCLAKKYTHL--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QRCIEGTCICKLP------ --------------YQCPK------------------------------NGT-------A VCATNRRS---------------------------------------------------- ----------------------------------------FPTYCQQKSL---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPGTKFLNNGTCTA-------EG KFSVSLKHGI----TDSE--GIVEVKLV-----DQDKTMFICKSSWSMREANVACLDLGF -----QQGA-DTQRRFKL-----SDLSINSTECLHVHCRGLETSLAECTFTK--RRTMG- YQDLADVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKA------- ------------------------CQG--KSFHCKSGVCIPSQYQCNG------------ --------EVDCITGEDEVG--CE----------------AARHPTIQ------------ -----------------------------------GFASVAQEETEI------------L TADMDAERRRIKSLLPKL-------------------SCGV--KNRMH------------ -----------IRRKRIVGGKRAQLGDLPWQVAIKD----ASGITCGGIYIGGCWILTAA HCLRASKTHRYQIWTRVVDWIHPDRKRIVIEHVDRIIFHENYNAGTYQNDIALIEMKKDG NKKDCELP--RSIPACIPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLISN-- CS--KFYGNRF-YEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_005639325.1 complement factor I isoform X1 [Canis lupus familiaris] -----------------MKLVHVI---------------------LLHLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----CLS-------------------------------FC----------KD------- ------------------------------TDENQKQWIRK------------------- ------------------------------------------------------------ ---------------TQL---------SSLSNTPQVSLLDEKCLTERYTHL--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QKCIDGTCTCKLP------ --------------YQCPK------------------------------DGT-------S VCSTNGRS---------------------------------------------------- ----------------------------------------YPTYCQQKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPGAKFLNNGTCTA-------EG QFSISLNYGN----TTSE--GIVEVKLI-----HQDKKMFICKKSWSILEANVACVDLGF -----QQGAFDIQKTFEV----PEDQHKNLTECLQVHCRGLETSLAECTFTK--RR---- AKSVAGVVCYTENTVSAASDSFHCVNGKQIPQKRTCNGINDCGDQSDELCCTG------- ------------------------CHG--KSFFCKSGVCIPNKYKCNG------------ --------EVDCITGEDENG--CQ----------------GTE----------------- -------------------------------------HSEIKEETEY------------L TANMDAERKRIKSLLPKL-------------------FCGV--TNNVL------------ -----------SRRKRVVGGKAAVMGDFPWQVAIKE----NEKIKCGGIYIGGCWILTAA HCVSVSRIYQYQIWTSFLSSLRPD-NDTVVQLAKQIIVHENYSGATYENDIALIELRKRS NQKECSLP--HSIPACVPWSSYLFQPNDRCTVSGWGREK-DNQKVYVLKWGDVKLIDN-- CS--KFYPGRY-FEKEMVCAGTDDGSIDACKGDSGGPLVCKDINNVTYVWGVVSWGENCG NPEYPGVYTKVANYFDWISHHVGRSLISQYNV >NP_001033185.1 complement factor I precursor [Bos taurus] -----------------MKLGHVI---------------------LLLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------ED------- ----------------------------NFRKRGKSKAVKKSE----------------A HHAPEAS----------------------------------------------------- -----LSKETEASSEVKP---------TSTQDTSQKDFVDKKCLTEKHTHL--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QKCIDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YSTYCQQKSF---------- ------------------------------------------------------------ --------------ECY------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------GG QFSVSLSNGK----QDSE--GIVAVKLA-----DLDTKMFVCGDSWSITEANVACIDRGF -----QLGALDTHRR---------DPDPNSAECLHVRCRGLETSLAECTFTK--GVHN-- SEGLAGVVCYTESAAPPKKDSFQCVNGKRIPQRKACDGVNDCVDKSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------ETG----------------- -------------------------------------HPEIKEAAEM------------L TADMDAERKFTKSFLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGEFPWQMAIKE----GDKIHCGGIYIGGCWILTAA HCVRISRMHRYQIWTSFTDWLRPG-FQTVVHSVNRIIIHENYNGTTYQNDIALIEMKKRP NEKECVLS--KSIPACVPWSPYLFQPNDKCIVSGWGREK-DNQKVYSLRWGEVHLINN-- CS--EFYPGRY-FEKEMQCAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG KSEFPGVYTKVANYFDWISQHVGRSLISQHNI >XP_024101436.1 complement factor I isoform X1 [Pongo abelii] -----------------MKLLHVF---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLS-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTYTSQEDLVEKKCLAKKHTHL--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QICIEGTCICKLP------ --------------YQCPK------------------------------NGT-------T VCATNGRS---------------------------------------------------- ----------------------------------------FPTYCQQKSL---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPGTKFLNNGTCTA-------EG KFSVSLKHGN----TDSE--GIVEVKLV-----DQDKTMFICKSSWSMREANVACLDLGF -----QQGA-DTQRRFKL-----SNLSINSTECLHVHCRGLETSLAECTFTK--RRTMG- YQDLADVVCYTQKADSPTNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKA------- ------------------------CQG--KSFHCKSGVCIPSQYRCNG------------ --------EVDCITGEDEVG--CE------------------------------------ -----------------------------------GFASVAQEETEI------------L TADMDAERRRIKSLLPKL-------------------SCGV--KNRRH------------ -----------IRRKRIVGGKRAQLGDLPWQVGIKD----ASGITCGGIYIGGCWILTAA HCLRASKTHHYQIWTTVVDWIHPDRKRIVIEYVDRIIFHENYNAGTYQNDIALMEMKKDG NKKDCELP--RSIPACVPWSPYLFQPNDTCIVSGWGREK-DNEKVFSLQWGEVKLISN-- CS--KFYGNRF-YEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_002717177.2 PREDICTED: complement factor I isoform X1 [Oryctolagus cuniculus] MWLEKHLRQRQILNTSNMKLIHVL---------------------LSLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FY----------R-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------V---------TSTSNASPEDLVEKKCLMKKYTHL--------- ---------------------------SC------------------------------- --------------SKVFC-------QPW------------QKCIDGTCVCKLP------ --------------YQCPK------------------------------NGT-------S VCATNGKS---------------------------------------------------- ----------------------------------------YPSYCHQKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------HPGTKFLNNGKCTP-------EG KFNVSLKYGN----TDSE--GIVEVKLV-----EQDKSMFICKRSWSIREANVVCFDLGF -----QQGAVDVQGRFHF----PENLHINSTECLNVRCQGLETSLAECTFTK--RRNKG- YQNLAGVVCFTQNAGSPKNESFQCVNGKNIPWKKACDGVNDCGDQSDELCCKG------- ------------------------CQG--ESFLCKSGVCIPRQHICND------------ --------ELDCITGEDEVG--CE----------------EADHRAVQ------------ -----------------------------------DFLPVAQETTKI------------L AVDMDAERRRIKSLLPKL-------------------SCGV--RKNLQ------------ -----------TRRKRIVGGKPAQVGQFPWQVAIKH----DNRINCGGIYIGGCWVLTAA HCVSAHKAHQYQIWTGLLNWIIPN-SELIVELVNKIIIHENYNGTTYQNDIALIEMKKRP NQKQCDLP--NSVPACLPWSPYLFQPNERCIISGWGRDK-DNQKVYSLSWGEVNLLSN-- CS--KFYANRF-YEKEMECAGTNDGSIDACKGDSGGPLVCKDINNVTYVWGIVSWGENCG KPEFPGVYTKVANYFDWISYHVGRSLIARYNI >XP_013844801.1 complement factor I [Sus scrofa] M-------------VSNMKLAHVI---------------------LLLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------P---------TSGSDTSQEDLVEKKCLTEKYTHL--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QKCIDGTCICKLP------ --------------YQCPK------------------------------NGT-------S VCSTNGKS---------------------------------------------------- ----------------------------------------YPTYCQQKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EE QFSVSLDRGN----GDSE--GIVEVKLV-----DQDKKMYICAKSWSLTQANVACLDLGF -----KLGALYTQRR---------DPHINSPECLHVHCRGSETSLAECTFTK--GTTSR- SEGLAGVVCYTENAVSPTNDYFQCVNGKHISQKKTCDGINDCGDQSDELCCKG------- ------------------------CRG--ESFFCKSGVCIPRKYKCNG------------ --------EVDCITGEDEVG--CE----------------GSE----------------- -------------------------------------HPEIKEETEM------------L TADMNAERKRIKSFFPKL-------------------SCGV--KSSTH------------ -----------IRRKRVVGGQPAEVGDFPWQVAIKE----GEKINCGGIYIGGCWILTAA HCVRASKAPRYQIWTSFTDWLNPD-PQIVVQFVKQVIIHEKYNGTTYQNDIALIEMKKQP GRSECVLL--KSVPACVPWSPHLFQPNDKCIVSGWGREK-DNKKVYSLKWGEVHLISN-- CS--KFYLNRF-FEKEMVCAGTDDGSIDACKGDSGGPLVCTDANNMTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISLHVGRPLISQHNV >XP_003205784.1 complement factor I [Meleagris gallopavo] -----------------MRVVA-----------------------VFLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SFFS-------------------------------FC----------RA------- ------------------------QNAASNDTEE-FSYVEP------------------- ------------------------------------------------------------ -------------AQPVE---------QDSQPAERDTYLLEDCLSNKYTHK--------- ---------------------------SC------------------------------- --------------KKVFC-------HPW------------ERCVEGKCLCKLP------ --------------YQCPK------------------------------NGT-------S VCSTTGKQ---------------------------------------------------- ----------------------------------------FHTYCHLKSY---------- ------------------------------------------------------------ --------------ECQ------------------------------------------- -------------------------------------RPEAKFLNKGKCMS-------TE TFKISLVYKD----S-----HLLQVKPV-----NN-EDLFVCDSMWTTNEANVACRHLGF -----ELGAEYYHTDYNI-----TE----PSHCFQITCRGLETSLAECYIEK--KLRAS- NEGFVSLQCQKTLREC-SASEFHCANDKCISVTKTCDGINDCGDLSDELCCKE------- ------------------------CRN--NSFHCRSNICIPNKNVCNK------------ --------EIDCLTGEDEAQALCS------------------------------------ --------------------------------------GKPKHEE--------------- NLSMDAERKLAKTFLPQI-------------------NCGV--VNLTL------------ -----------TRRKRIIGGQIARKGEFPWQVAIKDTGTEGATVYCGGVYIGGCWVLTAA HCVRATRVHLYRVWIGLLDTIEYD-KETDTYRLKQLIIHEKYNAATYENDIALLELKGH- GKGECSLK--YSTPACIPWSEHMFKAGDKCKVSGWGLEK-GYTKQYVLKWGNVNLFQN-- CS--EMYPGRF-LQ-KMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWGENCG EAGHPGVYTQVASYYDWISHHVTRSLISRYNI >XP_003830061.1 complement factor I isoform X1 [Pan paniscus] -----------------MKLLHVF---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----HLR-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTYTSQEDLVEKKCLAKKYTHL--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QRCIEGTCICKLP------ --------------YQCPK------------------------------NGT-------A VCATNRRS---------------------------------------------------- ----------------------------------------FPTYCQQKSL---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPGTKFLNNGTCTA-------EG KFSVSLKHGI----TDSE--GIVEVKLV-----DQDKTMFICKSSWSMREANVACLDLGF -----QQGA-DTQRRFKL-----SDLSINSTECLHVHCRGLETSLAECTFTK--RRTMG- YQDLADVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKA------- ------------------------CQG--KSFHCKSGVCIPSQYQCNG------------ --------EVDCITGEDEVG--CE----------------AARHPTIQ------------ -----------------------------------GFASVAQEETEI------------L TADMDAERRRIKSLLPKL-------------------SCGV--KNRMH------------ -----------IRRKRIVGGKRAQLGDLPWQVAIKD----ASGITCGGIYIGGCWILTAA HCLRASKTHRYQIWTRVVDWIHPDRKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG NKKDCELP--RSIPACIPWSPYLFQPNDTCIVSGWGREK-DNERVFSLQWGEVKLISN-- CS--KFYGNRF-YEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_006930977.2 complement factor I isoform X1 [Felis catus] -----------------MKLAHVI---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YKS-------------------------------FC----------KD------- ------------------------------TDENQEQWTKK------------------- ------------------------------------------------------------ ---------------PQL---------PSTSYIPQKDLLDNKCLIEKYTHL--------- ---------------------------SC------------------------------- --------------KKVFC-------QPW------------QKCIDGTCICKLP------ --------------YQCPK------------------------------NGT-------S VCSTNGKS---------------------------------------------------- ----------------------------------------YLTYCQQKSF---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------QPTAKFLNSGTCIA-------EG QFSVSLKYGT----TTSE--GIVEVKLV-----DQDKKMFICKKAWSIVEANVACLELGF -----QQGALEAQKSFEV----PEDLHINSTECLHVHCRGLETSLAECTFIK--RRTKN- YQDLAGVVCYTQNTVSSANDSFRCVNGKYIPQKKTCNGVNDCGDQSDELCCKG------- ------------------------CRG--KSFLCKSGVCIPNKYKCNG------------ --------ELDCITGEDEIG--CK----------------GERRIDLTHVSGDDDHR--- -----------------------------------PGHSEIKEETEL------------L TANMDAERKRIKSLLPKL-------------------SCGV--KPIRP------------ -----------TRRKRVVGGKPAEVGDFPWQVAIKD----NEKINCGGIYIGGCWILTAA HCVSVSKAHHYQIWTSFLHLLRPE-EELVVQLANKIIIHENYNGSSYENDIALIEMKKHS KRKECVLP--NSVPACVPWSPYLFQPNDRCIISGWGREK-DNQKVYSLQWGEVKLLDN-- CS--KFYPGRY-FEKKMECAGTDDGSIDACKGDSGGPLVCQDINNVTYVWGVVSWGENCG KPEFPGIYTKVANYFDWISYHVGRSLISQYNI >XP_004009671.1 complement factor I [Ovis aries] -----------------MKLGHVI---------------------LLLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------ED------- ----------------------------NFRKQGQSKAVKKSQ----------------A HHAPEAS----------------------------------------------------- -----LSKETEASSEVKL---------TSTPDTSQKDFVDKKCLTEKHTHL--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QRCIDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YSTYCQQKSF---------- ------------------------------------------------------------ --------------ECV------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EG QFSVSLSNGK----QDSE--GLVAVQLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----QLGALDTHRR---------DPDLNSAECLHVRCRGLETSLAECTFTK--GVHS-- SEGLAAMVCYTEEAAPPKKDSFQCVNGKRIPQKKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------GTG----------------- -------------------------------------HPEIKEAAEV------------L TADMDAERKFIKSFLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQIAIKE----SDKIHCGGTYIGGCWILTAA HCVRISRMHRYQLWTSFTDWIRPG-FQTVVHSVNRIIIHENYNGTTYQNDIALIEMKKRP SEKQCVLS--NSVPACVPWSPYLFQPNDKCIISGWGREK-GNQKVYSLKWGEVHIINN-- CS--AFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGIVSWGENCG KSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_018880871.1 complement factor I isoform X1 [Gorilla gorilla gorilla] -----------------MKLLHVF---------------------LLFLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----CLR-------------------------------FC----------K-------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------VTYTSQEDLVEKKCLAKKYTHL--------- ---------------------------SC------------------------------- --------------DKVFC-------QPW------------QRCIEGTCICKLP------ --------------YQCPK------------------------------NGT-------A VCATNRRS---------------------------------------------------- ----------------------------------------FPTYCQQKSL---------- ------------------------------------------------------------ --------------ECL------------------------------------------- -------------------------------------RPGTKFLNNGTCTA-------EG KFSVSLKHGI----TDSE--GIVEVKLV-----DQDKTMFICKSSWSMREANVACLDLGF -----QQGA-DTQRRFKL-----SDLSINSTECLHVHCRGLETSLAECTFTK--RRTMG- YQDLADVVCYTQKADSPMNDFFQCVNGKYISQMKACDGINDCGDQSDELCCKA------- ------------------------CQG--KSFHCKSGVCIPSQYQCNG------------ --------EVDCITGEDEVG--CE------------------------------------ -----------------------------------GFASVAQEETEI------------L TADMDAERRRIKSLLPKL-------------------SCGV--KNRTH------------ -----------IRRKRIVGGKRAQLGDLPWQMAIKD----ASGITCGGIYIGGCWILTAA HCLRASKTHRYQIWTTVVDWIHPDRKRIVIEYVDRIIFHENYNAGTYQNDIALIEMKKDG NKKDCELP--RSIPACIPWSPYLFQPNDTCIVSGWGREK-DNERVFSLRWGEVKLISN-- CS--KFYGNRF-YEKEMECAGTHDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCG KPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_004079594.1 complement factor I [Oryzias latipes] M---------------STRRISSS---------------------LLLLFL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LIL-------------------------------CS------------------- ----------------GASNPADKEEPSSIGQQMNQEHLKP------------------- -RLPKPRP---------------------------------------------------- -----SPVTTSPAPAAPA---------TPAPPQTDEFLGPLECLDKKLTRA--------- ---------------------------SC------------------------------- --------------GRVFC-------SPW------------QRCIDGVCSCKPP------ --------------YMCPR------------------------------DGV------KA VCTRNHKR---------------------------------------------------- ----------------------------------------YLSYCQAMAM---------- ------------------------------------------------------------ --------------SCT------------------------------------------- -------------------------------------TKKAVLSHFGEVCGE-----SVK KFSSSIDKQT----------GVVKLFLP---DDGVGEELLVCHGQWNMAAANVACREEHN HPGLESMGAASAFAVNYSQ--ISGGAEPLPRRCVNVRCQGFEFSLAECEIYN--RVDIG- DGAVAAARCYDSRPP--EDCGFTCANDKCVSLNQTCDGVDDCGDRSDEMCCKK------- ------------------------CRN--RAFRCNTGVCVHPDAVGDH------------ --------QLDCLGGEDETP--KH----------------LNTI---------------- -----------------------------------ARTTKQEAEPPE------------Y VSRRNETKTTRHLLESNL-------------------VCGI--PNMDL--------VDET EEHVRGR---ISRKKRVVGGVEAKPTQIQWQVALQE----HGRIDCGGAYVGGCWVITAA HCVRR-NPAAFKVKFSLWKKYAPQ-GSTDIVPVEEIIIHPNYNPATYENDIALVKLKKYP YRDYCVEENPAIRAVCVPWSIELFQPNYTCSISGWGRTK-TGKSAEVLLWANVSLIEG-- CQ--SSYKHRF-KA-GMMCAGDLDGNVDSCQGDSGGPLVCQDQLGVSYLWGIVSWGDKCG KRGYPGVYTQVAYFFEWIRSHTGWPAVTKFNS >XP_005515274.1 complement factor I [Columba livia] -----------------MTVVP-----------------------VFLVFL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SLFW-------------------------------FC----------GS------- ------------------------EHASSNAKENQFQQVEP------------------- ------------------------------------------------------------ -----------------------------TQPAEQDPYLIKECLSNQYTHK--------- ---------------------------SC------------------------------- --------------EKVFC-------HPW------------ERCVEGKCLCKLP------ --------------YQCPK------------------------------NGS-------S VCSANGKY---------------------------------------------------- ----------------------------------------FHTYCQLKSY---------- ------------------------------------------------------------ --------------ECQ------------------------------------------- -------------------------------------RPEAKFLHKGKCAS-------KE TFAISVDHGD----S-----HLLRVKPV-----NQKNAMFVCGSEWTMNEANVACRHLGF -----ESGAEHYQANSSI-----TESALNSLHCLQITCRGLETSLAECHIQV--KSRDS- NEGFVSLQCHENLRVC-SAGEFHCVNKKCISLTKTCDGINDCGDLSDELCCRE------- ------------------------CRD--NSFHCRSNICIPNKNVCNK------------ --------EIDCLTGEDEARVLCA------------------------------------ --------------------------------------GKHKGAE--------------- NHSMDKERKRIKTFLPKV-------------------HCGL--TNHTL------------ -----------TRRKRIVGGETARKGEFPWQVAITEAGSDGATLYCGGVYIGGCWVLTAA HCVRANRIHLYRVWVGLLDTIEYD-KGTHTYTLKQLIIHEKYNASSYENDIALLELS--- GKGECSLA--QSTPACVPWSQYMFRPGDTCKVSGWGLEK-GYTKQYILKWGNVNLFQN-- CS--ELYPGRF-FE-QMACAGTYDGSVDSCKGDSGGPLVCFDADNVAYVWGIVSWGENCG EAGHPGVYTKVASYYDWISHHVTRSLISRYNI >XP_005681373.2 PREDICTED: complement factor I [Capra hircus] -----------------MKLGHVS---------------------LLLVCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------ED------- ----------------------------NFRKQGQSKAVKKSE----------------A HHAPEAS----------------------------------------------------- -----LSKETEASSEVKL---------TSTPDTSQKDFVDKKCLIEKHTHL--------- ---------------------------SC------------------------------- --------------NKVFC-------QPW------------QRCIDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YSTYCQQKSF---------- ------------------------------------------------------------ --------------ECV------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EG QFSVSLSNGK----QDSE--GLVAVQLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----QLGALDTHRR---------DPDLNSAECLHVRCRGLETSLAECTFTK--GVHN-- SEGLAAMVCYTEEAAPPKKDSFQCVNGKRIPQKKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------GTG----------------- -------------------------------------HPEIKEAAEV------------L TADMDAERKFIKSFLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQIAIKE----SDKIHCGGTYIGGCWILTAA HCVRISRTHRYQLWTSFTDWIRPG-FQTVVHSVNQIIIHENYNGTTYQNDIALIEMKKRP SEKQCVLS--NSVPACVPWSPYLFQPNDKCIISGWGREK-GNQKVYSLKWGEVHIINN-- CS--AFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG KSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_025062148.1 LOW QUALITY PROTEIN: complement factor I [Alligator sinensis] -----------------MKV-------------------------LLLLGF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SCVF-------------------------------FC----------TYGG----- ------------------------KVFQNQTSEYNXXXXXX------------------- ------------------------------------------------------------ -------------XXXXX---------QQVQPSHKETHLVGECLKEKYTQD--------- ---------------------------SC------------------------------- --------------EKVFC-------LPW------------KRCVSGNCICKLP------ --------------YQCPK------------------------------NGT-------S VSSINGKT---------------------------------------------------- ----------------------------------------FRTYCQLKSY---------- ------------------------------------------------------------ --------------ECQ------------------------------------------- -------------------------------------RPEAKYMSKGDYIH-------GE KFDVSLNYGD----SESE--GVIQVKLV-----NNTEKLFLCNSKWSMNEANVACRHRGF -----ETGAEYHRKTFTV-----PEHNNTSSCCLQVICRGVETSLAECKLIK--RSPPGG VKNFATVACHKVQREC-TPQEFCCANKKCIPLTETCNGINDCGDLSDELCCKE------- ------------------------CKI--KSFLCNSGVCIPKKYLCNK------------ --------EIDCLTGEDELQVNCE----------------DEQNVELE--TQDQDDEGQN PETETQGQQS--------------GNKEADHKVIIRTRAKGKAQEVI------------P NYNADEERRAIKTFLPEL-------------------KCGI--TNHTV------------ -----------TRRKRIVGGNPAAKGEFPWQVAIKEEGGTGPSVYCGGVYIGGCWILTAA HCVRATRVHQYRIWSGLLDTIQYN-REIDTFKLNKVIIHEKYNAGTYENDIALLEMKSMD KGKPCSLA--YSTPACVPWSEYMFKPGHRCKISGWGLER-DSAKQFVLKWGYIDILSN-- CT--EIYKDRF-FK-GMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCG VAGYPGVYTKVASYFDWISHQVGRALISKYNV >XP_014453781.1 PREDICTED: complement factor I isoform X1 [Alligator mississippiensis] -----------------MKL-------------------------LLLLGF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----SCVF-------------------------------FC----------TYGG----- ------------------------KVFQNQTSEYN------------------------- ------------------------------------------------------------ --------------KEPV---------QQVQPTHKETHLVGECLKEKYTQD--------- ---------------------------SC------------------------------- --------------EKVFC-------LPW------------KRCVSGNCICKLP------ --------------YQCPK------------------------------NGT-------S VSSINGKT---------------------------------------------------- ----------------------------------------FRTYCQLKSY---------- ------------------------------------------------------------ --------------ECQ------------------------------------------- -------------------------------------RPEAKYMSKGDCIH-------GE KFDVSLNYGD----SESE--GVIQVKLV-----NNTEKLFLCNSKWSMNEANVACRHRGF -----EAGAEYHRKTFTV-----PEHNNTSSWCLQVICRGEETSLAECKLIK--RSPPGG VKNFATVACHKFQREC-TPQEYCCANKKCIPLTETCNGINDCGDLSDELCCKE------- ------------------------CKN--KSFLCNSGVCIPKKYLCNK------------ --------EVDCLTGEDELQVNCE----------------DEQNVELE--TQDQDDEGQN PETETQGQQSGEQSPEPDVQGQYFGNKEADHKVIIRTRAKGKAQEVI------------P NYNADEERRAIKTFLPEL-------------------KCGI--TNHTV------------ -----------TRCKRIVGGNPAAKGEFPWQVAIKEEGGTGPSVYCGGVYIGGCWILTAA HCVRATRVHQYRIWSGLLDTIQYN-REIDTFKLNKVIIHEKYNAGTYENDIALLEMKSMD KGKPCSLA--YSTPACVPWSEYMFKPGHRCKISGWGLER-DSAKQFVLKWGYIDILSN-- CT--EIYKDRF-FK-GMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCG VAGYPGVYTKVASYFDWISHQVGRALISKYNV >XP_015831712.1 PREDICTED: complement factor I [Nothobranchius furzeri] -----------------MRRQS-----------------------LFLLLL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LLF-------------------------------CSETLAGKQKPKRKTTTTAP- KP--------------AATTPAATTPPATTPPATTPAATTP------------------- -AATTPAAT--------------------------------------------------- -----TPAATTPAATTPA-------ALTTKAPHTDEYLG--ECQNKRLTRD--------- ---------------------------SC------------------------------- --------------GLAFC-------LPW------------QRCIDGQCTCKPP------ --------------YQCPM------------------------------EGM------KP VCGNNNRN---------------------------------------------------- ----------------------------------------YRSFCQAMAL---------- ------------------------------------------------------------ --------------SCR------------------------------------------- -------------------------------------TKKPLFSHFGEQCNA-----NVK KFESSLDNET----------GVVRIFLPG--STGQGEWLLVCQDMWDMAAANVACREKSH -----SLGAASAEARVYNDLMVNSEITNLPGSCVSIRCQGYETSLAECEIYD--KVDAV- DMMVAAATCYIS-----AECGFTCENTKCISLNQTCDGVDDCGDRSDEMCCKK------- ------------------------CRN--GAFHCKTGICVHKDGVGDN------------ --------QLDCLDGADEAV--KH----------------TTAA---------------- -----------------------------------SNDANQARGPTA------------Y VSRKNETRTNRMILESQL-------------------HCGI--PNKTF--------EGSE NSHDRGH---SSRRKRVVGGAEARPTQIQWQVALEE----NQRIDCGGAYIGGCWVITAA HCVRP-RPSAFRVKFSLWKKFRAQ-GTTDIVPVEEIRIHPNYVASTYENDIALVKLEKLP FTDKCLLDNPAIRPVCVPWSTHLFQPNHTCSISGWGRNK-EGKAAQVLLWANVSLIAG-- CE--SSYKDRF-KP-GMICAGDVDGHVDSCQGDSGGPLVCEDELGVSYLWGIVSWGEKCG QPGFPGVYTQVAHYFEWIRLHTGWPAVTRFNS >XP_020743606.1 complement factor I [Odocoileus virginianus texanus] -----------------MAPDKPLRPADGEAQGEGGLEWTGRRQRLRSNCG--------- ------------------------------------------------------------ ----------PEI----------TAG---------------------------------- ------------------------------------------------------------ -------------------AGA------TDPS---------------------------- --------------------------------------------PPQP------------ --PSPKLS-------------------------------LR----------KRP------ ---------------------------TAYSGKRKSKAVKK------------------- ------------------------------------------------------------ ---------------SEP---------ASTPGTSQKDFVDKKCLTAKYTHL--------- ---------------------------SC------------------------------- --------------EKVFC-------QPW------------QKCVDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YPTYCQQKSF---------- ------------------------------------------------------------ --------------ECF------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EG QFSVSLSNGK----RDSE--GVVAVKLA-----DQDRKIFVCGDSWSITQANVACLDLGF -----PLGALDTHRR---------DPDLNSAECLHVHCRGLETSLAECTFTK--GVINI- LKGLAGMACYTESAAPPEKDSFQCVNGKRIPQKKACDGVNDCVDNSDEMCCKD------- ------------------------CQG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------GTR----------------- -------------------------------------HLEIKEEAEM------------L TADMDAERKFAKSLLPKL-------------------SCGV--KNSMH------------ -----------IRRKRVVGGKPAKMGDFPWQVAIKE----DDKIHCGGIYIGGCWILTAA HCVRVSRIHRYQLWTSFTDWLKPD-SEIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRP NQKECVLS--KSIPACVPWSPYLFQPNDKCIISGWGREK-GNQKVYSLMWGEVHLINN-- CS--KFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG NPEFPGVYTKVANYFDWISLHVGRALISQHNV >XP_030287044.1 complement factor I-like [Sparus aurata] -----------------MRSAGVS---------------------LFLLFL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----LIA-------------------------------YSEM--------ETT------ ------------------------------------------------------------ ---PTTQP---------------------------------------------------- -----TTMVNSSAPTIPG---------T---NETDKFFGPQECWDKKLTRA--------- ---------------------------SC------------------------------- --------------DLVFC-------PPW------------ERCIRGHCSCKTP------ --------------YLCPAV----------------------------VNGV-------P VCGRDNRN---------------------------------------------------- ----------------------------------------YRSFCQVMAV---------- ------------------------------------------------------------ --------------SCR------------------------------------------- -------------------------------------TRKPVMSHFGLNCGD-----NQP KFNTSIDPET----------RVVKVFVPDARSPNGGEELLVCGKTWNMAAANVACKEKGT -----PLGAMAAHRIEHN----NPTATNFPSSCVNVRCQGYETSLAECVIYD--KVRIA- TKNLATATCYEAPSD--TACGFTCVNGKCVSLEQTCDGVDDCGDGSDEMCCKA------- ------------------------CRK--GAFLCKTGVCVPKDALHDK------------ --------QIDCLDGKDESP--KH----------------TLDNM--------------- -----------------------------------REPVPQQLRNSD------------Y ISSKDETAKTREHLESRL-------------------ECGI--PNMDI--------VDDE VFEERGR---SSRTKRVVGGIPSKPTQIQWQIALGD----KGKIDCGGAYIGGCWVLTAA HCVRP-NPSAFMVYFSMWKKSSAQ-GTTDIVLVKNIQIHPKYNASSYENDIALVQLEKLP FSDKCLEDNPAVRAVCVPWSTELFRTNHTCSISGWGRTA-EGKRSRVLLWANVSLIDN-- CG--NFYGHRFNKD-SMLCAGDLEGKVDSCQGDDGGPLVCEDELGVSYLWGIVSWGEKCG QPGFPGVYTQVAHYFEWIRLHTGWPAVTKFNS >XP_040185110.1 complement factor I [Rana temporaria] -----------------MKTSSLV---------------------WFLLSL--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------ACVCIATDTYTQKECLTEKHTYN--------- ---------------------------SC------------------------------- --------------QKVFC-------DPW------------KRCVDGKCICKPP------ --------------YQCPK------------------------------NKT------MG VCTESQRT---------------------------------------------------- ----------------------------------------FLTYCQLKSA---------- ------------------------------------------------------------ --------------ECS------------------------------------------- -------------------------------------NAAYRFASNSPCK---------G KFEISVKKRNG-NIVKNN--GTVLIKLP-----GDTKEFPVCPAKWTITEANVACKQLGF -----PQGALSEPLKASF----KEDVQGQHTECLHVTCRGTETSMAECIMKK---DTVS- ENLWAAVNCYKEKRDC-TDDEFTCVNEKCIPAEHACNGDDNCGDRSDELCCSD------- ------------------------CR---NSFHCSSDICIPKHYVCNG------------ --------QMDCLKGEDEAK--CKV-EGSEGEG-------SENRENNE--GKDHNLKGE- -----------------------------------RSENNNDDVEPQVPQDKKTDLVNAV NFDIEAEIKLIKESISSV-------------------SCGIPVKQPDI------------ -----------KRFKRIIGGTKAKENQFPWQVAIKD----GAKVNCGGIYIGGCWVLTAA HCVRADQPHKYRVIIELLDRLSVS-ENVDSFPVKTVKVHENYKSGTYENDIALLEVVNIY KEPACMQVDNNLVPACVPWSTHLFKTGDTCVVSGWGREE-GFTKVFHLKWGNINLMNN-- CT--SIYKDRF-LN-GMECAGTYDGSIDACKGDSGGPLICYDANNVAYVWGVVSWGENCG VAGFPGVYSKVAYYFEWISRHVGRALISKYNI >XP_043727043.1 complement factor I isoform X2 [Cervus elaphus] -----------------MKLGHVI---------------------LLLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------E-------- ----------------------------VTFGKRKSKAVKK------------------- ------------------------------------------------------------ ---------------SEP---------ASTPGTSQKDFVDEKCLTAKYTHL--------- ---------------------------SC------------------------------- --------------KKVFC-------QPW------------QKCVDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YQTYCQQKSF---------- ------------------------------------------------------------ --------------ECF------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EE QFSVSLSNGK----QDSE--GVVAVKLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----PLGALDTHGR---------DPDLNSAECLHVHCRGLETSLAECTFTK--GVINI- LNGLAGMECYTESAAPPKKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CEE-------NRSKSLSQGTR----------------- -------------------------------------LLEIKEEAEM------------L TADMDAERKFTKSLLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQVAIKE----GDKIHCGGIYIGGCWILTAA HCVRVSRIHRYQLWTSFTDWLKPD-TDIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRP NQKECVLS--KSVPACVPWSPHLFQPNDKCIISGWGREK-GNQKVYSLMWGEVHLINN-- CS--KFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG NPEFPGVYTKVANYFDWISLHVGRALISQHNV >XP_043294407.1 complement factor I isoform X2 [Cervus canadensis] -----------------MKLGHVI---------------------LLLLCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YLS-------------------------------FC----------E-------- ----------------------------ATFGKRKSKAVKK------------------- ------------------------------------------------------------ ---------------SEP---------ASTPGTSQKDFVDEKCLTAKYTHL--------- ---------------------------SC------------------------------- --------------KKVFC-------QPW------------QKCVDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YQTYCQQKSF---------- ------------------------------------------------------------ --------------ECF------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EA QFSVSLSNGK----QDSE--GVVAVKLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----PLGALDTHGR---------DPDLNSAECLHVHCRGLETSLAECTFTK--GVINI- LNGLAGMECYTESAAPPKKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CEE-------NRSKSLSQGTR----------------- -------------------------------------RLEIKEEAEM------------L TADMDAERKFTKSLLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQVAIKE----GDKIHCGGIYIGGCWILTAA HCVRVSRIHRYQLWTSFTDWLKPD-TDIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRP NQKECVLS--KSVPACVPWSPHLFQPNDKCIISGWGREK-GNQKVYSLMWGEVHLINN-- CS--KFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG NPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0368187.1 hypothetical protein FD755_019953 [Muntiacus reevesi] -----------------M----VF---------------------QLVCCF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----YVRERG--------------------------RETCCLI------PHHP------ ----------------------------LTLSLSLKCTVFT------------------- ------------------------------------------------------------ ---------------VRP---------ASTPDTSQKDFVDKKCLTAKYTHL--------- ---------------------------SC------------------------------- --------------EKVFC-------QPW------------QKCVDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YPTYCQQKSF---------- ------------------------------------------------------------ --------------ECF------------------------------------------- -------------------------------------RPEAKFLKSGACTV-------EG QFSVSLSHGK----QDSE--GVVAVRLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----PLGALDTHGR---------DPDLNSAECLHVHCRGSETSLAECTFTK--GVINI- LKGLAGMECYTESAAPPEKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------GTR----------------- -------------------------------------HLEIKEEAEM------------L TADMDAERKFAKSLLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQVAIKE----GDKIHCGGIYIGGCWILTAA HCVRISRIHRYQLWTSFTDWLKPD-TEIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRP NQKECVLS--KSVPACVPWSPYLFQPNDKCIVSGWGREK-GNQKVYSLMWGEVHLINN-- CS--KFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG NPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0342649.1 hypothetical protein FD754_019575 [Muntiacus muntjak] -----------------MDRGTWR------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----ATS---------------------------------------------------- ----------------------------EQRKRKIQSKLTRGS----------------Y HHKPGA------------------------------------------------------ ------HQEGLMCITLPP---------ASTPDTSQKDFVDKKCLTAKYTHL--------- ---------------------------SC------------------------------- --------------EKVFC-------QPW------------QKCVDGTCLCKLP------ --------------YQCPK------------------------------NGT-------R VCSTNGKS---------------------------------------------------- ----------------------------------------YPTYCQQKSF---------- ------------------------------------------------------------ --------------ECF------------------------------------------- -------------------------------------RPEAKFLKSGACTG-------EG QFSVSLSNGK----RDSE--GVVAVRLA-----DQDRKMFVCGDSWSITQANVACLDLGF -----PLGALDTHGR---------DPDLNSAECLHVRCRGSETSLAECTFTK--GVINI- LKGLAGMECYTESAAPPEKDSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKD------- ------------------------CRG--EGFLCKSGVCIPKQYKCNG------------ --------ELDCITGEDEVG--CE----------------GTR----------------- -------------------------------------HLEIKEEAEM------------L TADMDAERKFAKSLLPKL-------------------SCGV--KNNMH------------ -----------IRRKRVVGGKPAKMGDFPWQVAIKE----GDKIHCGGIYIGGCWILTAA HCVRISRIHRYQLWTSFTDWLKPD-TEIVVQFVNQIIIHENYNGTTYQNDIALIEMKKRP NQKECVLS--KSVPACVPWSPYLFQPNDKCIVSGWGREK-GNQKVYSLMWGEVHLINN-- CS--KFYPGRY-FEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCG NPEFPGVYTKVANYFDWISLHVGRALISQHNV >NP_001079421.1 complement factor I S homeolog precursor [Xenopus laevis] -----------------MNKLSCV------------F--------ILLFHF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----WVN-------------------------------TF------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------TITVSGAEEAKPDKC---EFNAL--------- ---------------------------SC------------------------------- --------------HKIFC-------APW------------QKCLAGVCRCKLP------ --------------YQCPK------------------------------NAT------TE VCTVGKRK---------------------------------------------------- ----------------------------------------LQSYCQLKSV---------- ------------------------------------------------------------ --------------ECPN------------------------------------------ --------------------P---------------LNGKYRFSSEAPCT---------D AFSIRLIGEA------GK--GIIKVKLP-----TFEKEFFICKKQWSIREANVFCKQLGF -----PSGADASASDKVVP---LITEESPEEHCLQATCRGLENSLAECALKK---LPME- GNQVAEVKCYTEKKDC-GSGEFTCSNGKCIPSDLACDSENDCGDLSDELCCRG------- ------------------------CT---AGFHCKSDTCIPEQYRCNG------------ --------ELDCIGGEDESN--CA----------------VKQEQKSE--KQEEVKQEQ- -----------------------------------RSEKQEEGVNQE------------L KATQEEERRLLMKSLPEL-------------------SCGVPPVTSTL------------ -----------TRKKRVIGGTNAVKNQFPWQVAIKD----GTSVNCGGIYIGGCWVLTAA HCVRANQPQRYLIILELLDRLSYD-KDIDSFPVKSVLVHESYNPNTYENDIALLEVKNIY NNPKCMQTDNNMVPACVPWSPFQFRTGDTCTVSGWGREK-GMSRVFHLKWGHINLMNN-- CT--EVYKERF-LD-KMECAGTYDGSIDACKGDSGGPLVCYDVNKVAYVWGIVSWGENCG VPGFPGVYTKVAHYFEWISRHVGRSLISKYNV >XP_039258771.1 transmembrane protease serine 6-like [Styela clava] -----------------MSNLFED--------------------DSFLLVF--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------RGVNVR --TRKYVG---------------------Y---------YSGN--------KSGSVYR-- -----------------------SRYHQISIVFTSDESTTR------------------- ------------------------------------------------------------ -----SGFNISYKTGTPQ---------TLKACPGNSYIVALGMESGEIKDG--------- ---QI----------------------SA------------------------------- --------------SSAFS-------QQW---KPSLSRLNNRRGAWISAKAVLP------ -----RHRS-----YKLPT----------------------------------------- ----TQNQ---WIQIDL----------LRNRVVTGIVTQGFILTSGD------------- ---------------------------------------LFVTSFSILFR---------- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------KSRKTWREYREGIDP-----RLK VFKANIDGRT---------SCNIQFSHP-----FAARYLRIIPRSWTGQYIVMRMEILG- -------------------------------------CSG-STSLA-------------- -----------NDDEC-GEDDFECGDGTCISRELICDKNNDCDDKSDEVDCAK------- ------------------------CRN--FQFKCGSGECILRKKRCDG------------ --------SKDCSDATDEMG--CSRCHGDDFQCHDESMCLKIKRVCDE--YKDCD----- -----------------------------------DFSDERNCSHPW------------L CPVHTDYKCSDRSCVPGINLKCNGFTDCDDSSDENDCDCGTS-PKFDSNVILDETLVSST NSRSRRSVTNSGRFPRIVGGMDADIESWPWQVSIEK--SKDKEHFCGGALISNRFILTAA HCLVAKKKADIRIKMGLNHLTETE--NTQSFNASRVFMHPRYDAQTYDFDIALIKID--- -GNATLSD--RTRKICLPPSSHIFHEGQSCWITGWGTTSVRGRRSETLQEARVELMTNDQ CNRPRWYAGKI-TP-RMICAGDSNGSVDSCQGDSGGPLVCQERGGKWFVAGIVSWGNGCG VAYKPGVYTRMTEMIHWVEDIMEKE---DGDG >XP_038060987.1 uncharacterized protein LOC119731787 isoform X3 [Patiria miniata] -----------------MRAIRLL-----------GFTI-----ALFLLLE-VDHVFSKE LGLKSRSKIKEKKLHPPKRVDKVYYVS------NRHRRDSGSSDEGDDEDEEETGEGDYR AQYGKPN---------APNTHKNTGGAPQAETEYS--IRLVNGRNEYEGRVEVKKDASSR WGLVCDDYWGMEEATVVCRQLGYGDPVEAVSNALNRFSGSIGKKQYVMDDIQCRGTEDAL QLCQFAGWGVTNCISDIEVAGIVCSPPNMDPD---------------------------- ------------------------------------------ANPESPECFTDSRGADYR GFVSTTVSGKTCQKWTVQTPHTHRHTPDRFPDDGLGDHNYC----------RTVSEVNAE RPWCYTVSA-ARREYCDVGLPQVSCNRQAVAEQ----RTNPMEHFALFQNAAIPGANMEE HHGVTAEQCAELCLATTSFSCRSFDHYRDDNRCWLSDKSSHSSDLKFDFNNNPFDYYERI DIGTLSQFEIIPNAAIAGHNEEEHQGVSMQRCAQLCVLATFGCASFDYARRTSQCWLSRA TTETANLRTDIEAQPFDYFQRNGGAMPDCYRGNGHSYRGSYSATETGKDCVPWTFAAARG AGVNNAQYPNTGVGNHNHCRNPDNDQQPWCYFADA------SGQLEGWTYCGLPACQLTG PAESETPTT-----TQAPGGLRLLSQGKETVQSSTLTLTGVAREASLAVDGNASPHFDDN SCTLTDSERHPWWYVDLGREYEIDHIVIVNRYDNGNRLKRATVRVGDAILNVDSFLECGQ VTGAMIKNAAKREHRQITIQCSAETVGRYVYIEQTRNQALHLTLCEVEVYGQDVT--ATG PPPSISCSSEQFACVTGGIHCIPNSWVCDQDPDCEDGTDEQGCNDPLADFNPLADSAIPS SINPDVTYMDKTLAECAQFCVTNMDIVCRSFEYEAATRDCSLFDENRAQTGGLEARPGVT HYERLSQTTDCSNVDGELYHPCPSGRCVPTRWLCDGDNDCGDFSDERQCSVEGPTQEPSS EFAIRIVNDQLGQTSTNEYQGRVEVQYM-------GVWGTVCDDNWDIQDATVVCKQLGF -----TRGAVSAVIVGEF-----GQGN-GNIIMDDVECAGTEMSLADCPFSGWGVHNCV- AREAAGVICIPNEG-C-LDSQFECGNGDCIPLNWKCDGTDDCGDNSDEQQCQS--ADLPV RLVGGPDANSGRIEVMFAGQWGTVCD---DRFDDNAAQVVCRQLGITGNSRVFEKAHFGQ GQGQIWLDEVQCQGGENHLG-ECG------------------------------------ ---------------------------------------HSRFGSND------------C SHGEDVGVECGIVPVPEVTMAPG--------------SCGV--KQVDN------------ -----------GINARIIGGTAAKKGSWPWQAQLLL---RQSGHYCGATLIDEFHVLTAA HCFQRYGKDRFKVRLGEHDQYRSE-NSEQDFDIECLHLHEDYSSSTTNNDIALIKLKPKN GRGAQMNT--HVSPACLTGRDD-LPDNHQCWISGWGNTG--NDYPRLLQEARVPLLPRST CTGRRVYGSKL-TS-RMLCAGYLGGGIDSCDGDSGGPLVCE-YQGTWQIIGVTSWGSGCA QPNAPGVYSRVNQFLDWINTKRQTAQC----- >XP_030835556.1 uncharacterized protein LOC578177 isoform X1 [Strongylocentrotus purpuratus] -----------------MGSLKFV-----------CLCL----GALMCVSTLMTHV---- -----DAKLKAKKIHAPSYASKVDLVQVTEEGRHRERRD-------DDDDDDEDIDSDID PVIAELNRLLAEIRTIQDGAQVDTQGQNRAASSHRHPVRLQGGTSEYDGRVEINYE--DQ WYMVCDDYWGIEEATVVCNQLGFNGALEAVQRAADEY--GFNDNGFAMDDVRCTGMEPGL SECDFPEWRSHNCDKGEEVAGVRCQPERTSPNRAIRSVQGAPTIPDSSQIMLRFNVNELP PWLQSILGSKPSETSTPGSATGGTVAGSSGATGSDGSSQVPVTRARDPECFTMSNGQDYR GVVRQTISGYACQRWNVQTPHGHSYTPAQYPGI-LGNHNHC----------RNPGTFS-- QPWCYTTNPRIIREYCDVGNPRTSCATTAQTVQGNGEATTYLSEYALVPAAYLGGNNDGT HSVATAELCAERCNKERSFVCRSFEYNEQSNECLTSSSNSRDVDLTFLLSTR-FNYYERL DIGPIALFDITPNSAMPGNNIESLTAVSMEECAERCLVAAWPCASFDFARRANRCWLSNK SPSQVSIRSDFPDNPYDFFSRRGPATPNCYLGTGENYRGFSFTTTQGHQCTNWQAAAMDN VGVTPVLFPDGDIGNHNFCRNPDSDRRPWCYYKDS-----GSSTVSGWMYCNISTCETST APPTSRPTARPPPPTQAPSGPIPVSRGKPAFQSSTHTSGGIMANAGLAVDGNPNPSFDQG SCSRTQSRANSWWYIDLEAAYDVTTVVIVNKDVQGERLRGAMVTIGSSATDPSTRTQCGR ITRTMTNAASRTPHQRIRIDCPSPIRGQYVHIGSPRKD--YLSFCEVEVYGRPSSPPTPA PEPTVSCTAAEFECASGSVSCVPERFQCNGQSDCTDGSDETGCPDPMDDFTIIADKYLPN R-EPAVIYMEKTADECARFCVSAMTFVCRSFDYNSAERTCSLFNVSRSQNGRLFSRQGTA HYERISQTTDCTNANGIEYHPCPSGRCIPNEWLCDGDNDCGDFTDESNCGT-------LE EFEVRIVNGT----APNE--GRVEVKYR-------GKWGLVCDDEWDLSDGHVVCRQLGY -----TRGASDVYIVGEF-----GHGNLVDIFMDDVRCTGNEQSLADCPHPGWGVNNCV- VGEAAGVLCKLNQD-C-PANHFECNNLKCIPEGNVCNDMDNCNDGSDELNCQPELPVLPV RLVGGNGRTSGRVEVFHNNQWGTVCD---DYFSEAAARVVCNQLGISGDVQVYPQAIFGE GTTQIWLDDVTCAGTEPSLA-QCT------------------------------------ --------------------------------------IPNGIGRHN------------C QHNEDVGVECGRETLP----------------------CGV--RGIEN------------ ----------GNIMARIIGGSSAKRGNWPWQAQLIL---RGSGHYCGGTLIDETHVLTAA HCFQRYGKNSFKVRLGEHHQHINE-SSEQDFRISCIYKHPDYDSRTTNNDIAVLRLD--- -RPAHITS--FVTPACLPTDGE-FAADHQCWISGWGNTG-NDNYPSRLQEARVPLLPRST CTRQNVYGNKL-TP-QMLCAGYLRGGIDSCDGDSGGPLVCENSNSVWKVVGVTSWGYGCA QPNAPGVYAVVTRYLGFINEKMITRTCT----
BMGE Cleaned alignment of selected proteins >sp|P05156|CFAI_HUMAN Complement factor I OS=Homo sapiens OX=9606 GN=CFI PE=1 SV=2 LLFLCFKKCLAKKYTHLDKVFCQRCIEGTCVCKLPYQCPKAVCATNRRSFPTYCQQKSLHPGTKFLNNGTCTAEGKFSVSLKHGNGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGA-DTTECLHVHCRGLETSLAECTFTKDFADVVCYTFFQCVNGKYISQMKACDGINDCGDQSDELCCKAKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGMDAERRRIKSLLPKLIRRKRIVGGKRAQLGDLPWQVAIKDSGITCGGIYIGGCWILTAAHCLRASKTRYQIWTTVVDWVDRIIFHENYNAGTYQNDIALIEMKKDDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >tr|A0A0G2L5F9|A0A0G2L5F9_DANRE Complement factor I OS=Danio rerio OX=7955 GN=cfi PE=1 SV=2 -----------------------------------Y-------------------------------------------------------------------------------------------DQCMKVRCTGSELSLAECTIYNQVAVANCYNKFRCVNGKYVNYGKLCDGIDDCGDNSDEMCCQDNAFWCPSGVCIPRHAVRDGVRDCLGGEDELELAEIKKIRSTAESKLQRRKRLVGGEESLPTQIQWQVAIQDGSIHCGGVYLGGCWVLTAAHCVRP-KPSFRVKFSLWRKVKKIIIHENYDAQTYVNDIALVQLEELKCMLDAIRAVCVPWSTQQFQPNDTCTISGWGRDKAGMSASILKWANVTIIGDNFYKHRFLP-GMECAGDLEGKVDSCQGDSGGPLVCKDASGLSYVWGIVSWGDKCGEPNHPGVYTKVAHYFDWIRFNTGWAAVTKFNQ >NP_031712.2 complement factor I isoform 1 preproprotein [Mus musculus] LFLLALQKCLLQKYTHRNKVFCQRCIEGTCICKLPYQCPRPVCAMNGRSYPTYCHQKSFHPEIKFSHNGTCAAEGKFNVSLIYGRGLVQVKLVDQDERMFICKNSWSMAEANVACVDLGFPLGVRDITECLHVHCRGVETSLAECAFTKGLAGVVCYKSFQCVNGKHIPQEKACNGVNDCGDQSDELCCKGNASLCKSGVCIPDQYKCNGEVDCITGEDESRMDNERKRIKSLLPKLTRRKRVIGGKPANVGDYPWQVAIKDQRITCGGIYIGGCWILTAAHCVRPSRASYQVWTALLDWVKRVIVHEKYNGATFQNDIALIEMKMHECELPNSVPACVPWSPYLFQPNDRCIISGWGRGKDNQKVYSLRWGEVDLIGNQFYPDRYYEKEMQCAGTRDGSIDACKGDSGGPLVCEDINNVTYVWGIVSWGENCGKPEFPGVYTRVANYFDWISYHVGRSLVSQHNV >NP_077071.1 complement factor I precursor [Rattus norvegicus] LLLLNPQKCLLKNYTHHDKVFCQKCIEGTCACKLPYQCPKPVCATNGRGYPTYCHLKSFHPEIKFSNNGTCTAEEKFNVSLIYGSGIVQVKLVDQDEKMFICKNSWSTVEANVACFDLGFPLGVRDITECLHVRCQGVETSLAECTFTKGLAGVVCYTSFQCVNGKRIPQEKACDGVNDCGDQSDELCCKGQAFLCKSGVCIPNQRKCNGEVDCITGEDESGMDTERKRIKSLLPKLIRRKRVVGGKPAEMGDYPWQVAIKDDRITCGGIYIGGCWILTAAHCVRPSRYNYQVWTSLLDWVSRVVVHEKYNGATYQNDIALVEMKKHECELINSVPACVPWSPYLFQPNDRCIISGWGREKDNQKVYSLRWGEVDLIGNRFYPGRYYEKEMQCAGTSDGSIDACKGDSGGPLVCKDVNNVTYVWGIVSWGENCGKPEFPGVYTRVASYFDWISYYVGRPLVSQYNV >NP_001258947.1 complement factor I precursor [Gallus gallus] VLLVCFEECLSNKYTHKKKVFCERCVEGKCLCKLPYQCPKSVCSTTGKNFYTYCHLKSFRSEAKFLNKGKCMSTETFKISLVYNDHLLQVKPVNN-EDLFVCDSMWTMNEANVACRHLGFELGAEYYSHCFQITCRGLETSLAECYIEKGFVSLQCQKEFHCANDKCISVTKTCDGINDCGDLSDELCCKENSFHCRSNICIPNKNVCNKEVDCLTGEDEAQMDAERKLAKTFLPQITRRKRIIGGQTARKGEFPWQVAIKDATVYCGGVYIGGCWVLTAAHCVRATRVQYRVWIGLLDTLKQLIIHEKYDAATYENDIALLELKGHECSLKYSTPACVPWSEHMFKAGDKCKVSGWGLEKGYTKQYVLKWGNVNLFQNEMYPGRFFQ-KMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWGENCGEAGHPGVYTQVASYYDWISHHVSRSLISRYNI >XP_003310493.1 complement factor I isoform X1 [Pan troglodytes] LLFLCFKKCLAKKYTHLDKVFCQRCIEGTCICKLPYQCPKAVCATNRRSFPTYCQQKSLRPGTKFLNNGTCTAEGKFSVSLKHGIGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGA-DTTECLHVHCRGLETSLAECTFTKDLADVVCYTFFQCVNGKYISQMKACDGINDCGDQSDELCCKAKSFHCKSGVCIPSQYQCNGEVDCITGEDEVGMDAERRRIKSLLPKLIRRKRIVGGKRAQLGDLPWQVAIKDSGITCGGIYIGGCWILTAAHCLRASKTRYQIWTRVVDWVDRIIFHENYNAGTYQNDIALIEMKKDDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_005639325.1 complement factor I isoform X1 [Canis lupus familiaris] LLHLCFEKCLTERYTHLNKVFCQKCIDGTCTCKLPYQCPKSVCSTNGRSYPTYCQQKSFRPGAKFLNNGTCTAEGQFSISLNYGNGIVEVKLIHQDKKMFICKKSWSILEANVACVDLGFQQGAFDITECLQVHCRGLETSLAECTFTKSVAGVVCYTSFHCVNGKQIPQKRTCNGINDCGDQSDELCCTGKSFFCKSGVCIPNKYKCNGEVDCITGEDENGMDAERKRIKSLLPKLSRRKRVVGGKAAVMGDFPWQVAIKEEKIKCGGIYIGGCWILTAAHCVSVSRIQYQIWTSFLSSAKQIIVHENYSGATYENDIALIELRKRECSLPHSIPACVPWSSYLFQPNDRCTVSGWGREKDNQKVYVLKWGDVKLIDNKFYPGRYFEKEMVCAGTDDGSIDACKGDSGGPLVCKDINNVTYVWGVVSWGENCGNPEYPGVYTKVANYFDWISHHVGRSLISQYNV >NP_001033185.1 complement factor I precursor [Bos taurus] LLLLCFKKCLTEKHTHLNKVFCQKCIDGTCLCKLPYQCPKRVCSTNGKSYSTYCQQKSFRPEAKFLKSGACTGGGQFSVSLSNGKGIVAVKLADLDTKMFVCGDSWSITEANVACIDRGFQLGALDTAECLHVRCRGLETSLAECTFTKGLAGVVCYTSFQCVNGKRIPQRKACDGVNDCVDKSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFTKSFLPKLIRRKRVVGGKPAKMGEFPWQMAIKEDKIHCGGIYIGGCWILTAAHCVRISRMRYQIWTSFTDWVNRIIIHENYNGTTYQNDIALIEMKKRECVLSKSIPACVPWSPYLFQPNDKCIVSGWGREKDNQKVYSLRWGEVHLINNEFYPGRYFEKEMQCAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGKSEFPGVYTKVANYFDWISQHVGRSLISQHNI >XP_024101436.1 complement factor I isoform X1 [Pongo abelii] LLFLCFKKCLAKKHTHLNKVFCQICIEGTCICKLPYQCPKTVCATNGRSFPTYCQQKSLRPGTKFLNNGTCTAEGKFSVSLKHGNGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGA-DTTECLHVHCRGLETSLAECTFTKDLADVVCYTFFQCVNGKYISQMKACDGINDCGDQSDELCCKAKSFHCKSGVCIPSQYRCNGEVDCITGEDEVGMDAERRRIKSLLPKLIRRKRIVGGKRAQLGDLPWQVGIKDSGITCGGIYIGGCWILTAAHCLRASKTHYQIWTTVVDWVDRIIFHENYNAGTYQNDIALMEMKKDDCELPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNEKVFSLQWGEVKLISNKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_002717177.2 PREDICTED: complement factor I isoform X1 [Oryctolagus cuniculus] LSLLCFKKCLMKKYTHLSKVFCQKCIDGTCVCKLPYQCPKSVCATNGKSYPSYCHQKSFHPGTKFLNNGKCTPEGKFNVSLKYGNGIVEVKLVEQDKSMFICKRSWSIREANVVCFDLGFQQGAVDVTECLNVRCQGLETSLAECTFTKNLAGVVCFTSFQCVNGKNIPWKKACDGVNDCGDQSDELCCKGESFLCKSGVCIPRQHICNDELDCITGEDEVGMDAERRRIKSLLPKLTRRKRIVGGKPAQVGQFPWQVAIKHNRINCGGIYIGGCWVLTAAHCVSAHKAQYQIWTGLLNWVNKIIIHENYNGTTYQNDIALIEMKKRQCDLPNSVPACLPWSPYLFQPNERCIISGWGRDKDNQKVYSLSWGEVNLLSNKFYANRFYEKEMECAGTNDGSIDACKGDSGGPLVCKDINNVTYVWGIVSWGENCGKPEFPGVYTKVANYFDWISYHVGRSLIARYNI >XP_013844801.1 complement factor I [Sus scrofa] LLLLCFKKCLTEKYTHLDKVFCQKCIDGTCICKLPYQCPKSVCSTNGKSYPTYCQQKSFRPEAKFLKSGACTGEEQFSVSLDRGNGIVEVKLVDQDKKMYICAKSWSLTQANVACLDLGFKLGALYTPECLHVHCRGSETSLAECTFTKGLAGVVCYTYFQCVNGKHISQKKTCDGINDCGDQSDELCCKGESFFCKSGVCIPRKYKCNGEVDCITGEDEVGMNAERKRIKSFFPKLIRRKRVVGGQPAEVGDFPWQVAIKEEKINCGGIYIGGCWILTAAHCVRASKARYQIWTSFTDWVKQVIIHEKYNGTTYQNDIALIEMKKQECVLLKSVPACVPWSPHLFQPNDKCIVSGWGREKDNKKVYSLKWGEVHLISNKFYLNRFFEKEMVCAGTDDGSIDACKGDSGGPLVCTDANNMTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISLHVGRPLISQHNV >XP_003205784.1 complement factor I [Meleagris gallopavo] VFLLCFEDCLSNKYTHKKKVFCERCVEGKCLCKLPYQCPKSVCSTTGKQFHTYCHLKSYRPEAKFLNKGKCMSTETFKISLVYKDHLLQVKPVNN-EDLFVCDSMWTTNEANVACRHLGFELGAEYYSHCFQITCRGLETSLAECYIEKGFVSLQCQKEFHCANDKCISVTKTCDGINDCGDLSDELCCKENSFHCRSNICIPNKNVCNKEIDCLTGEDEAQMDAERKLAKTFLPQITRRKRIIGGQIARKGEFPWQVAIKDATVYCGGVYIGGCWVLTAAHCVRATRVLYRVWIGLLDTLKQLIIHEKYNAATYENDIALLELKGHECSLKYSTPACIPWSEHMFKAGDKCKVSGWGLEKGYTKQYVLKWGNVNLFQNEMYPGRFLQ-KMACAGTYDGSIDSCKGDSGGPLVCFDAENVAYVWGVVSWGENCGEAGHPGVYTQVASYYDWISHHVTRSLISRYNI >XP_003830061.1 complement factor I isoform X1 [Pan paniscus] LLFLCFKKCLAKKYTHLDKVFCQRCIEGTCICKLPYQCPKAVCATNRRSFPTYCQQKSLRPGTKFLNNGTCTAEGKFSVSLKHGIGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGA-DTTECLHVHCRGLETSLAECTFTKDLADVVCYTFFQCVNGKYISQMKACDGINDCGDQSDELCCKAKSFHCKSGVCIPSQYQCNGEVDCITGEDEVGMDAERRRIKSLLPKLIRRKRIVGGKRAQLGDLPWQVAIKDSGITCGGIYIGGCWILTAAHCLRASKTRYQIWTRVVDWVDRIIFHENYNAGTYQNDIALIEMKKDDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISNKFYGNRFYEKEMECAGTYDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_006930977.2 complement factor I isoform X1 [Felis catus] LLFLCFNKCLIEKYTHLKKVFCQKCIDGTCICKLPYQCPKSVCSTNGKSYLTYCQQKSFQPTAKFLNSGTCIAEGQFSVSLKYGTGIVEVKLVDQDKKMFICKKAWSIVEANVACLELGFQQGALEATECLHVHCRGLETSLAECTFIKDLAGVVCYTSFRCVNGKYIPQKKTCNGVNDCGDQSDELCCKGKSFLCKSGVCIPNKYKCNGELDCITGEDEIGMDAERKRIKSLLPKLTRRKRVVGGKPAEVGDFPWQVAIKDEKINCGGIYIGGCWILTAAHCVSVSKAHYQIWTSFLHLANKIIIHENYNGSSYENDIALIEMKKHECVLPNSVPACVPWSPYLFQPNDRCIISGWGREKDNQKVYSLQWGEVKLLDNKFYPGRYFEKKMECAGTDDGSIDACKGDSGGPLVCQDINNVTYVWGVVSWGENCGKPEFPGIYTKVANYFDWISYHVGRSLISQYNI >XP_004009671.1 complement factor I [Ovis aries] LLLLCFKKCLTEKHTHLNKVFCQRCIDGTCLCKLPYQCPKRVCSTNGKSYSTYCQQKSFRPEAKFLKSGACTGEGQFSVSLSNGKGLVAVQLADQDRKMFVCGDSWSITQANVACLDLGFQLGALDTAECLHVRCRGLETSLAECTFTKGLAAMVCYTSFQCVNGKRIPQKKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFIKSFLPKLIRRKRVVGGKPAKMGDFPWQIAIKEDKIHCGGTYIGGCWILTAAHCVRISRMRYQLWTSFTDWVNRIIIHENYNGTTYQNDIALIEMKKRQCVLSNSVPACVPWSPYLFQPNDKCIISGWGREKGNQKVYSLKWGEVHIINNAFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGIVSWGENCGKSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_018880871.1 complement factor I isoform X1 [Gorilla gorilla gorilla] LLFLCFKKCLAKKYTHLDKVFCQRCIEGTCICKLPYQCPKAVCATNRRSFPTYCQQKSLRPGTKFLNNGTCTAEGKFSVSLKHGIGIVEVKLVDQDKTMFICKSSWSMREANVACLDLGFQQGA-DTTECLHVHCRGLETSLAECTFTKDLADVVCYTFFQCVNGKYISQMKACDGINDCGDQSDELCCKAKSFHCKSGVCIPSQYQCNGEVDCITGEDEVGMDAERRRIKSLLPKLIRRKRIVGGKRAQLGDLPWQMAIKDSGITCGGIYIGGCWILTAAHCLRASKTRYQIWTTVVDWVDRIIFHENYNAGTYQNDIALIEMKKDDCELPRSIPACIPWSPYLFQPNDTCIVSGWGREKDNERVFSLRWGEVKLISNKFYGNRFYEKEMECAGTHDGSIDACKGDSGGPLVCMDANNVTYVWGVVSWGENCGKPEFPGVYTKVANYFDWISYHVGRPFISQYNV >XP_004079594.1 complement factor I [Oryzias latipes] LLLLFLLECLDKKLTRAGRVFCQRCIDGVCSCKPPYMCPRAVCTRNHKRYLSYCQAMAMTKKAVLSHFGEVCGVKKFSSSIDKQTGVVKLFLPGVGEELLVCHGQWNMAAANVACREEHNSMGAASARRCVNVRCQGFEFSLAECEIYNAVAAARCYDGFTCANDKCVSLNQTCDGVDDCGDRSDEMCCKKRAFRCNTGVCVHPDAVGDHQLDCLGGEDETPRNETKTTRHLLESNLSRKKRVVGGVEAKPTQIQWQVALQEGRIDCGGAYVGGCWVITAAHCVRR-NPAFKVKFSLWKKVEEIIIHPNYNPATYENDIALVKLKKYYCVEEAIRAVCVPWSIELFQPNYTCSISGWGRTKTGKSAEVLLWANVSLIEGSSYKHRFKA-GMMCAGDLDGNVDSCQGDSGGPLVCQDQLGVSYLWGIVSWGDKCGKRGYPGVYTQVAYFFEWIRSHTGWPAVTKFNS >XP_005515274.1 complement factor I [Columba livia] VFLVFLKECLSNQYTHKEKVFCERCVEGKCLCKLPYQCPKSVCSANGKYFHTYCQLKSYRPEAKFLHKGKCASKETFAISVDHGDHLLRVKPVNQKNAMFVCGSEWTMNEANVACRHLGFESGAEHYLHCLQITCRGLETSLAECHIQVGFVSLQCHEEFHCVNKKCISLTKTCDGINDCGDLSDELCCRENSFHCRSNICIPNKNVCNKEIDCLTGEDEARMDKERKRIKTFLPKVTRRKRIVGGETARKGEFPWQVAITEATLYCGGVYIGGCWVLTAAHCVRANRILYRVWVGLLDTLKQLIIHEKYNASSYENDIALLELS--ECSLAQSTPACVPWSQYMFRPGDTCKVSGWGLEKGYTKQYILKWGNVNLFQNELYPGRFFE-QMACAGTYDGSVDSCKGDSGGPLVCFDADNVAYVWGIVSWGENCGEAGHPGVYTKVASYYDWISHHVTRSLISRYNI >XP_005681373.2 PREDICTED: complement factor I [Capra hircus] LLLVCFKKCLIEKHTHLNKVFCQRCIDGTCLCKLPYQCPKRVCSTNGKSYSTYCQQKSFRPEAKFLKSGACTGEGQFSVSLSNGKGLVAVQLADQDRKMFVCGDSWSITQANVACLDLGFQLGALDTAECLHVRCRGLETSLAECTFTKGLAAMVCYTSFQCVNGKRIPQKKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFIKSFLPKLIRRKRVVGGKPAKMGDFPWQIAIKEDKIHCGGTYIGGCWILTAAHCVRISRTRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRQCVLSNSVPACVPWSPYLFQPNDKCIISGWGREKGNQKVYSLKWGEVHIINNAFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGKSGFPGVYTKVANYFDWISHHVGRSLISQHNV >XP_025062148.1 LOW QUALITY PROTEIN: complement factor I [Alligator sinensis] LLLLGFGECLKEKYTQDEKVFCKRCVSGNCICKLPYQCPKSVSSINGKTFRTYCQLKSYRPEAKYMSKGDYIHGEKFDVSLNYGDGVIQVKLVNNTEKLFLCNSKWSMNEANVACRHRGFETGAEYHSCCLQVICRGVETSLAECKLIKNFATVACHKEFCCANKKCIPLTETCNGINDCGDLSDELCCKEKSFLCNSGVCIPKKYLCNKEIDCLTGEDELQADEERRAIKTFLPELTRRKRIVGGNPAAKGEFPWQVAIKEPSVYCGGVYIGGCWILTAAHCVRATRVQYRIWSGLLDTLNKVIIHEKYNAGTYENDIALLEMKSMPCSLAYSTPACVPWSEYMFKPGHRCKISGWGLERDSAKQFVLKWGYIDILSNEIYKDRFFK-GMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCGVAGYPGVYTKVASYFDWISHQVGRALISKYNV >XP_014453781.1 PREDICTED: complement factor I isoform X1 [Alligator mississippiensis] LLLLGFGECLKEKYTQDEKVFCKRCVSGNCICKLPYQCPKSVSSINGKTFRTYCQLKSYRPEAKYMSKGDCIHGEKFDVSLNYGDGVIQVKLVNNTEKLFLCNSKWSMNEANVACRHRGFEAGAEYHSWCLQVICRGEETSLAECKLIKNFATVACHKEYCCANKKCIPLTETCNGINDCGDLSDELCCKEKSFLCNSGVCIPKKYLCNKEVDCLTGEDELQADEERRAIKTFLPELTRCKRIVGGNPAAKGEFPWQVAIKEPSVYCGGVYIGGCWILTAAHCVRATRVQYRIWSGLLDTLNKVIIHEKYNAGTYENDIALLEMKSMPCSLAYSTPACVPWSEYMFKPGHRCKISGWGLERDSAKQFVLKWGYIDILSNEIYKDRFFK-GMECAGTHDGSIDSCKGDSGGPLICFDSNNVAYVWGVVSWGENCGVAGYPGVYTKVASYFDWISHQVGRALISKYNV >XP_015831712.1 PREDICTED: complement factor I [Nothobranchius furzeri] LFLLLL-ECQNKRLTRDGLAFCQRCIDGQCTCKPPYQCPMPVCGNNNRNYRSFCQAMALTKKPLFSHFGEQCNVKKFESSLDNETGVVRIFLPGQGEWLLVCQDMWDMAAANVACREKSHSLGAASAGSCVSIRCQGYETSLAECEIYDMVAAATCYIGFTCENTKCISLNQTCDGVDDCGDRSDEMCCKKGAFHCKTGICVHKDGVGDNQLDCLDGADEAVKNETRTNRMILESQLSRRKRVVGGAEARPTQIQWQVALEEQRIDCGGAYIGGCWVITAAHCVRP-RPAFRVKFSLWKKVEEIRIHPNYVASTYENDIALVKLEKLKCLLDAIRPVCVPWSTHLFQPNHTCSISGWGRNKEGKAAQVLLWANVSLIAGSSYKDRFKP-GMICAGDVDGHVDSCQGDSGGPLVCEDELGVSYLWGIVSWGEKCGQPGFPGVYTQVAHYFEWIRLHTGWPAVTRFNS >XP_020743606.1 complement factor I [Odocoileus virginianus texanus] LRSNCGKKCLTAKYTHLEKVFCQKCVDGTCLCKLPYQCPKRVCSTNGKSYPTYCQQKSFRPEAKFLKSGACTGEGQFSVSLSNGKGVVAVKLADQDRKIFVCGDSWSITQANVACLDLGFPLGALDTAECLHVHCRGLETSLAECTFTKGLAGMACYTSFQCVNGKRIPQKKACDGVNDCVDNSDEMCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFAKSLLPKLIRRKRVVGGKPAKMGDFPWQVAIKEDKIHCGGIYIGGCWILTAAHCVRVSRIRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRECVLSKSIPACVPWSPYLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >XP_030287044.1 complement factor I-like [Sparus aurata] LFLLFLQECWDKKLTRADLVFCERCIRGHCSCKTPYLCPAPVCGRDNRNYRSFCQVMAVTRKPVMSHFGLNCGQPKFNTSIDPETRVVKVFVPNGGEELLVCGKTWNMAAANVACKEKGTPLGAMAASSCVNVRCQGYETSLAECVIYDNLATATCYEGFTCVNGKCVSLEQTCDGVDDCGDGSDEMCCKAGAFLCKTGVCVPKDALHDKQIDCLDGKDESPKDETAKTREHLESRLSRTKRVVGGIPSKPTQIQWQIALGDGKIDCGGAYIGGCWVLTAAHCVRP-NPAFMVYFSMWKKVKNIQIHPKYNASSYENDIALVQLEKLKCLEDAVRAVCVPWSTELFRTNHTCSISGWGRTAEGKRSRVLLWANVSLIDNNFYGHRFKD-SMLCAGDLEGKVDSCQGDDGGPLVCEDELGVSYLWGIVSWGEKCGQPGFPGVYTQVAHYFEWIRLHTGWPAVTKFNS >XP_040185110.1 complement factor I [Rana temporaria] WFLLSLKECLTEKHTYNQKVFCKRCVDGKCICKPPYQCPKGVCTESQRTFLTYCQLKSANAAYRFASNSPCK--GKFEISVKKRNGTVLIKLPGDTKEFPVCPAKWTITEANVACKQLGFPQGALSETECLHVTCRGTETSMAECIMKKLWAAVNCYKEFTCVNEKCIPAEHACNGDDNCGDRSDELCCSDNSFHCSSDICIPKHYVCNGQMDCLKGEDEAKIEAEIKLIKESISSVKRFKRIIGGTKAKENQFPWQVAIKDAKVNCGGIYIGGCWVLTAAHCVRADQPKYRVIIELLDRVKTVKVHENYKSGTYENDIALLEVVNIACMQVNLVPACVPWSTHLFKTGDTCVVSGWGREEGFTKVFHLKWGNINLMNNSIYKDRFLN-GMECAGTYDGSIDACKGDSGGPLICYDANNVAYVWGVVSWGENCGVAGFPGVYSKVAYYFEWISRHVGRALISKYNI >XP_043727043.1 complement factor I isoform X2 [Cervus elaphus] LLLLCFEKCLTAKYTHLKKVFCQKCVDGTCLCKLPYQCPKRVCSTNGKSYQTYCQQKSFRPEAKFLKSGACTGEEQFSVSLSNGKGVVAVKLADQDRKMFVCGDSWSITQANVACLDLGFPLGALDTAECLHVHCRGLETSLAECTFTKGLAGMECYTSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFTKSLLPKLIRRKRVVGGKPAKMGDFPWQVAIKEDKIHCGGIYIGGCWILTAAHCVRVSRIRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRECVLSKSVPACVPWSPHLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >XP_043294407.1 complement factor I isoform X2 [Cervus canadensis] LLLLCFEKCLTAKYTHLKKVFCQKCVDGTCLCKLPYQCPKRVCSTNGKSYQTYCQQKSFRPEAKFLKSGACTGEAQFSVSLSNGKGVVAVKLADQDRKMFVCGDSWSITQANVACLDLGFPLGALDTAECLHVHCRGLETSLAECTFTKGLAGMECYTSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFTKSLLPKLIRRKRVVGGKPAKMGDFPWQVAIKEDKIHCGGIYIGGCWILTAAHCVRVSRIRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRECVLSKSVPACVPWSPHLFQPNDKCIISGWGREKGNQKVYSLMWGEVHLINNKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0368187.1 hypothetical protein FD755_019953 [Muntiacus reevesi] QLVCCFKKCLTAKYTHLEKVFCQKCVDGTCLCKLPYQCPKRVCSTNGKSYPTYCQQKSFRPEAKFLKSGACTVEGQFSVSLSHGKGVVAVRLADQDRKMFVCGDSWSITQANVACLDLGFPLGALDTAECLHVHCRGSETSLAECTFTKGLAGMECYTSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFAKSLLPKLIRRKRVVGGKPAKMGDFPWQVAIKEDKIHCGGIYIGGCWILTAAHCVRISRIRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRECVLSKSVPACVPWSPYLFQPNDKCIVSGWGREKGNQKVYSLMWGEVHLINNKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >KAB0342649.1 hypothetical protein FD754_019575 [Muntiacus muntjak] ------KKCLTAKYTHLEKVFCQKCVDGTCLCKLPYQCPKRVCSTNGKSYPTYCQQKSFRPEAKFLKSGACTGEGQFSVSLSNGKGVVAVRLADQDRKMFVCGDSWSITQANVACLDLGFPLGALDTAECLHVRCRGSETSLAECTFTKGLAGMECYTSFQCVNGKRIPQEKACDGVNDCVDNSDELCCKDEGFLCKSGVCIPKQYKCNGELDCITGEDEVGMDAERKFAKSLLPKLIRRKRVVGGKPAKMGDFPWQVAIKEDKIHCGGIYIGGCWILTAAHCVRISRIRYQLWTSFTDWVNQIIIHENYNGTTYQNDIALIEMKKRECVLSKSVPACVPWSPYLFQPNDKCIVSGWGREKGNQKVYSLMWGEVHLINNKFYPGRYFEKEMECAGTDDGSIDACKGDSGGPLVCQDVNNVTYVWGVVSWGENCGNPEFPGVYTKVANYFDWISLHVGRALISQHNV >NP_001079421.1 complement factor I S homeolog precursor [Xenopus laevis] ILLFHFDKC---EFNALHKIFCQKCLAGVCRCKLPYQCPKEVCTVGKRKLQSYCQLKSVNGKYRFSSEAPCT--DAFSIRLIGEAGIIKVKLPTFEKEFFICKKQWSIREANVFCKQLGFPSGADASEHCLQATCRGLENSLAECALKKQVAEVKCYTEFTCSNGKCIPSDLACDSENDCGDLSDELCCRGAGFHCKSDTCIPEQYRCNGELDCIGGEDESNQEEERRLLMKSLPELTRKKRVIGGTNAVKNQFPWQVAIKDTSVNCGGIYIGGCWVLTAAHCVRANQPRYLIILELLDRVKSVLVHESYNPNTYENDIALLEVKNIKCMQTNMVPACVPWSPFQFRTGDTCTVSGWGREKGMSRVFHLKWGHINLMNNEVYKERFLD-KMECAGTYDGSIDACKGDSGGPLVCYDVNKVAYVWGIVSWGENCGVPGFPGVYTKVAHYFEWISRHVGRSLISKYNV >XP_039258771.1 transmembrane protease serine 6-like [Styela clava] SFLLVFLGMESGEIKDGSSAFSRRGAWISAKAVLPYKLPT-----TQNQFVTSFSILFRKSRKTWREYREGIDLKVFKANIDGRTCNIQFSHPFAARYLRIIPRSWTGQYIVMRMEILG---------------CSG-STSLA---------------DFECGDGTCISRELICDKNNDCDDKSDEVDCAKFQFKCGSGECILRKKRCDGSKDCSDATDEMGHTDYKCSDRSCVPGIGRFPRIVGGMDADIESWPWQVSIEKKEHFCGGALISNRFILTAAHCLVAKKKDIRIKMGLNHLASRVFMHPRYDAQTYDFDIALIKID--ATLSDRTRKICLPPSSHIFHEGQSCWITGWGTTSRGRRSETLQEARVELMTNRWYAGKITP-RMICAGDSNGSVDSCQGDSGGPLVCQERGGKWFVAGIVSWGNGCGVAYKPGVYTRMTEMIHWVEDIMEKE---DGDG >XP_038060987.1 uncharacterized protein LOC119731787 isoform X3 [Patiria miniata] LFLLLEFGCASFDYARRNHNHCSGQLEGWTYCGLPTQAPGNSCTLTDSEHLTLCEVEVYNDCGDFSDERQCSVSSEFAIRIVNDQGRVEVQYM--GVWGTVCDDNWDIQDATVVCKQLGFTRGAVSAIIMDDVECAGTEMSLADCPFSGEAAGVICIPQFECGNGDCIPLNWKCDGTDDCGDNSDEQQCQSDRFDDNAAQVVCRQLGITGEVQCQGGENHLGEDVGVECGIVPVPEVGINARIIGGTAAKKGSWPWQAQLLLSGHYCGATLIDEFHVLTAAHCFQRYGKRFKVRLGEHDQIECLHLHEDYSSSTTNNDIALIKLKPKAQMNTHVSPACLTGRDD-LPDNHQCWISGWGNTG-NDYPRLLQEARVPLLPRRVYGSKLTS-RMLCAGYLGGGIDSCDGDSGGPLVCE-YQGTWQIIGVTSWGSGCAQPNAPGVYSRVNQFLDWINTKRQTAQC----- >XP_030835556.1 uncharacterized protein LOC578177 isoform X1 [Strongylocentrotus purpuratus] LMCVSTWPCASFDFARRNHNFCSSTVSGWMYCNISTQAPSGSCSRTQSRYLSFCEVEVYNDCGDFTDESNCGTLEEFEVRIVNGTGRVEVKYR--GKWGLVCDDEWDLSDGHVVCRQLGYTRGASDVIFMDDVRCTGNEQSLADCPHPGEAAGVLCKLHFECNNLKCIPEGNVCNDMDNCNDGSDELNCQPDYFSEAAARVVCNQLGISGDVTCAGTEPSLAEDVGVECGRETLP--NIMARIIGGSSAKRGNWPWQAQLILSGHYCGGTLIDETHVLTAAHCFQRYGKSFKVRLGEHHQISCIYKHPDYDSRTTNNDIAVLRLD--AHITSFVTPACLPTDGE-FAADHQCWISGWGNTGNDNYPSRLQEARVPLLPRNVYGNKLTP-QMLCAGYLRGGIDSCDGDSGGPLVCENSNSVWKVVGVTSWGYGCAQPNAPGVYAVVTRYLGFINEKMITRTCT----
PhyML tree of selected proteins (XP_030835556_1_uncharacterized_protein_LOC578177_isoform_X1__Strongylocentrotus_purpuratus_:0.35112383,XP_038060987_1_uncharacterized_protein_LOC119731787_isoform_X3__Patiria_miniata_:0.29517461,(XP_039258771_1_transmembrane_protease_serine_6_like__Styela_clava_:1.77640238,(((XP_040185110_1_complement_factor_I__Rana_temporaria_:0.29771885,NP_001079421_1_complement_factor_I_S_homeolog_precursor__Xenopus_laevis_:0.33088074):0.16810635,(((XP_005515274_1_complement_factor_I__Columba_livia_:0.11328323,(NP_001258947_1_complement_factor_I_precursor__Gallus_gallus_:0.01593489,XP_003205784_1_complement_factor_I__Meleagris_gallopavo_:0.0184005):0.07327908):0.17162301,(XP_014453781_1_PREDICTED__complement_factor_I_isoform_X1__Alligator_mississippiensis_:0.01171291,XP_025062148_1_LOW_QUALITY_PROTEIN__complement_factor_I__Alligator_sinensis_:0.00347776):0.20711163):0.18882138,((((XP_005639325_1_complement_factor_I_isoform_X1__Canis_lupus_familiaris_:0.13165658,XP_006930977_2_complement_factor_I_isoform_X1__Felis_catus_:0.07009192):0.02611802,(XP_013844801_1_complement_factor_I__Sus_scrofa_:0.08791722,((XP_020743606_1_complement_factor_I__Odocoileus_virginianus_texanus_:0.01679167,((XP_043727043_1_complement_factor_I_isoform_X2__Cervus_elaphus_:0.00214697,XP_043294407_1_complement_factor_I_isoform_X2__Cervus_canadensis_:0.00000001):0.01322756,(KAB0368187_1_hypothetical_protein_FD755_019953__Muntiacus_reevesi_:0.00661424,KAB0342649_1_hypothetical_protein_FD754_019575__Muntiacus_muntjak_:0.00220365):0.01314929):0.00371051):0.02816736,(NP_001033185_1_complement_factor_I_precursor__Bos_taurus_:0.04521828,(XP_005681373_2_PREDICTED__complement_factor_I__Capra_hircus_:0.00748864,XP_004009671_1_complement_factor_I__Ovis_aries_:0.00320775):0.02494325):0.01706033):0.07329205):0.05718909):0.03846737,(XP_002717177_2_PREDICTED__complement_factor_I_isoform_X1__Oryctolagus_cuniculus_:0.12861464,(NP_031712_2_complement_factor_I_isoform_1_preproprotein__Mus_musculus_:0.08438622,NP_077071_1_complement_factor_I_precursor__Rattus_norvegicus_:0.06837557):0.1180205):0.01812376):0.04201723,(XP_024101436_1_complement_factor_I_isoform_X1__Pongo_abelii_:0.01197532,(sp_P05156_CFAI_HUMAN_Complement_factor_I_OS_Homo_sapiens_OX_9606_GN_CFI_PE_1_SV_2:0.00854557,(XP_018880871_1_complement_factor_I_isoform_X1__Gorilla_gorilla_gorilla_:0.00639949,(XP_003310493_1_complement_factor_I_isoform_X1__Pan_troglodytes_:0.00000001,XP_003830061_1_complement_factor_I_isoform_X1__Pan_paniscus_:0.00000001):0.00213371):0.00430183):0.01006882):0.10266576):0.25958949):0.11671268):0.35130257,(tr_A0A0G2L5F9_A0A0G2L5F9_DANRE_Complement_factor_I_OS_Danio_rerio_OX_7955_GN_cfi_PE_1_SV_2:0.30366086,(XP_030287044_1_complement_factor_I_like__Sparus_aurata_:0.20763313,(XP_015831712_1_PREDICTED__complement_factor_I__Nothobranchius_furzeri_:0.1505348,XP_004079594_1_complement_factor_I__Oryzias_latipes_:0.19874802):0.08234145):0.23660024):0.38835776):0.93634087):1.27980112);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)