PB0160

DATABASE

Click here to access PB0160 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0160	P61812	Transforming growth factor beta-2 proprotein	TGFB2	G-TSF, LDS4, TGF-beta2	Homo_sapiens	Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.

Domains

Gene Ontology

PF00019 (TGF_beta) PF00688 (TGFb_propeptide)

GO:0001540 (enables) amyloid-beta binding GO:0005102 (enables) signaling receptor binding GO:0005114 (enables) type II transforming growth factor beta receptor binding GO:0005125 (enables) cytokine activity GO:0005160 (enables) transforming growth factor beta receptor binding GO:0005515 (enables) protein binding GO:0008083 (enables) growth factor activity GO:0034714 (enables) type III transforming growth factor beta receptor binding GO:0042803 (enables) protein homodimerization activity GO:0000902 (involved in) cell morphogenesis GO:0001501 (involved in) skeletal system development GO:0001654 (involved in) eye development GO:0001666 (involved in) response to hypoxia GO:0001822 (involved in) kidney development GO:0001837 (involved in) epithelial to mesenchymal transition GO:0001843 (involved in) neural tube closure GO:0001942 (involved in) hair follicle development GO:0003007 (involved in) heart morphogenesis GO:0003148 (involved in) outflow tract septum morphogenesis GO:0003149 (involved in) membranous septum morphogenesis GO:0003179 (involved in) heart valve morphogenesis GO:0003181 (involved in) atrioventricular valve morphogenesis GO:0003184 (involved in) pulmonary valve morphogenesis GO:0003203 (involved in) endocardial cushion morphogenesis GO:0003215 (involved in) cardiac right ventricle morphogenesis GO:0003222 (involved in) ventricular trabecula myocardium morphogenesis GO:0003274 (involved in) endocardial cushion fusion GO:0003289 (involved in) atrial septum primum morphogenesis GO:0003407 (involved in) neural retina development GO:0006468 (involved in) protein phosphorylation GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway GO:0007435 (involved in) salivary gland morphogenesis GO:0007507 (involved in) heart development GO:0008219 (involved in) cell death GO:0008284 (involved in) positive regulation of cell population proliferation GO:0008285 (involved in) negative regulation of cell population proliferation GO:0008347 (involved in) glial cell migration GO:0008584 (involved in) male gonad development GO:0009410 (involved in) response to xenobiotic stimulus GO:0009611 (involved in) response to wounding GO:0009792 (involved in) embryo development ending in birth or egg hatching GO:0010002 (involved in) cardioblast differentiation GO:0010629 (involved in) negative regulation of gene expression GO:0010634 (involved in) positive regulation of epithelial cell migration GO:0010693 (involved in) negative regulation of alkaline phosphatase activity GO:0010718 (involved in) positive regulation of epithelial to mesenchymal transition GO:0010862 (involved in) positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010936 (involved in) negative regulation of macrophage cytokine production GO:0014068 (involved in) positive regulation of phosphatidylinositol 3-kinase signaling GO:0016477 (involved in) cell migration GO:0016525 (involved in) negative regulation of angiogenesis GO:0030097 (involved in) hemopoiesis GO:0030199 (involved in) collagen fibril organization GO:0030307 (involved in) positive regulation of cell growth GO:0030308 (involved in) negative regulation of cell growth GO:0030326 (involved in) embryonic limb morphogenesis GO:0030509 (involved in) BMP signaling pathway GO:0030593 (involved in) neutrophil chemotaxis GO:0031069 (involved in) hair follicle morphogenesis GO:0032147 (involved in) activation of protein kinase activity GO:0032570 (involved in) response to progesterone GO:0032874 (involved in) positive regulation of stress-activated MAPK cascade GO:0032909 (involved in) regulation of transforming growth factor beta2 production GO:0033630 (involved in) positive regulation of cell adhesion mediated by integrin GO:0035910 (involved in) ascending aorta morphogenesis GO:0042060 (involved in) wound healing GO:0042127 (involved in) regulation of cell population proliferation GO:0042416 (involved in) dopamine biosynthetic process GO:0042476 (involved in) odontogenesis GO:0042704 (involved in) uterine wall breakdown GO:0043525 (involved in) positive regulation of neuron apoptotic process GO:0045216 (involved in) cell-cell junction organization GO:0045726 (involved in) positive regulation of integrin biosynthetic process GO:0045747 (involved in) positive regulation of Notch signaling pathway GO:0045778 (involved in) positive regulation of ossification GO:0045787 (involved in) positive regulation of cell cycle GO:0045823 (involved in) positive regulation of heart contraction GO:0046580 (involved in) negative regulation of Ras protein signal transduction GO:0048103 (involved in) somatic stem cell division GO:0048566 (involved in) embryonic digestive tract development GO:0048666 (involved in) neuron development GO:0048699 (involved in) generation of neurons GO:0048839 (involved in) inner ear development GO:0050680 (involved in) negative regulation of epithelial cell proliferation GO:0050714 (involved in) positive regulation of protein secretion GO:0050778 (involved in) positive regulation of immune response GO:0051781 (involved in) positive regulation of cell division GO:0051794 (involved in) regulation of timing of catagen GO:0051795 (involved in) positive regulation of timing of catagen GO:0051891 (involved in) positive regulation of cardioblast differentiation GO:0060038 (involved in) cardiac muscle cell proliferation GO:0060065 (involved in) uterus development GO:0060317 (involved in) cardiac epithelial to mesenchymal transition GO:0060389 (involved in) pathway-restricted SMAD protein phosphorylation GO:0060395 (involved in) SMAD protein signal transduction GO:0060412 (involved in) ventricular septum morphogenesis GO:0060413 (involved in) atrial septum morphogenesis GO:0061626 (involved in) pharyngeal arch artery morphogenesis GO:0062009 (involved in) secondary palate development GO:0097191 (involved in) extrinsic apoptotic signaling pathway GO:1902256 (involved in) regulation of apoptotic process involved in outflow tract morphogenesis GO:1902895 (involved in) positive regulation of miRNA transcription GO:1903701 (involved in) substantia propria of cornea development GO:1904888 (involved in) cranial skeletal system development GO:1905006 (involved in) negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:1905007 (involved in) positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0030424 (located in) axon GO:0031093 (located in) platelet alpha granule lumen GO:0043025 (located in) neuronal cell body GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P61812|TGFB2_HUMAN Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 PE=1 SV=1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >sp|P61812-2|TGFB2_HUMAN Isoform B of Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >tr|Q7SZV4|Q7SZV4_DANRE Transforming growth factor beta OS=Danio rerio OX=7955 GN=tgfb2 PE=2 SV=1 MNLYVLSLLLLLDLAAVAVSLSTCSTVDMDQFKKKRIEAIRGQILSKLKLSSPPEIYPEP EEVSRGIIAIYNSTRDLLQEKANERAATCERQRSEEEYYAKEVHKIDMQPFYPSENVILS QHYYPYFRRLMFDVSSMEKNASNLVKAQLRIFRLQNPKARVFEQRIELYQVLGHKDLTSP TQRYINSKVVRTRTEGEWLSFDVTEAVSEWLLHRDRNKGFKISLHCPCCTFVPSNNYIIP NKSEELETRFAGIDDSFVNGGDLKMFKKRRHSGQSPHLLLMLLPSYRLESQHKSHRQKRA LDTAFCSRNVQDNRCLRSLYIDFKKDLGWRWIHEPKGYNANFCAGACPYLWSADTQHSNI LGLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS
Selected proteins from model organisms >sp|P61812|TGFB2_HUMAN Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 PE=1 SV=1 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSENAIPP TFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSP TQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRK KRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQH SRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >sp|P61812-2|TGFB2_HUMAN Isoform B of Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEP EEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPV VTTPSGSVGSLCSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVF RLQNPKARVPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLH HKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRK KNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW KWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >tr|Q7SZV4|Q7SZV4_DANRE Transforming growth factor beta OS=Danio rerio OX=7955 GN=tgfb2 PE=2 SV=1 MNLYVLSLLLLLDLAAVAVSLSTCSTVDMDQFKKKRIEAIRGQILSKLKLSSPPEIYPEP EEVSRGIIAIYNSTRDLLQEKANERAATCERQRSEEEYYAKEVHKIDMQPFYPSENVILS QHYYPYFRRLMFDVSSMEKNASNLVKAQLRIFRLQNPKARVFEQRIELYQVLGHKDLTSP TQRYINSKVVRTRTEGEWLSFDVTEAVSEWLLHRDRNKGFKISLHCPCCTFVPSNNYIIP NKSEELETRFAGIDDSFVNGGDLKMFKKRRHSGQSPHLLLMLLPSYRLESQHKSHRQKRA LDTAFCSRNVQDNRCLRSLYIDFKKDLGWRWIHEPKGYNANFCAGACPYLWSADTQHSNI LGLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_033393.2 transforming growth factor beta-2 proprotein isoform 1 preproprotein [Mus musculus] MHYCVLSTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHLPSENAIPPTFYRPYFRIVRFDVSTMEKN ASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQEW LHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYASGDQKTIKSTRKKTSGKTPH LLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGAC PYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS >NP_112393.2 transforming growth factor beta-2 proprotein precursor [Rattus norvegicus] MHYCVLRTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHFPSETVCPVVTTSSGSVGSFCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSQELEARFAG IDGTSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILY YIGNTPKIEQLSNMIVKSCKCS >XP_020919952.1 transforming growth factor beta-2 isoform X1 [Sus scrofa] MHYCVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >NP_001026216.2 transforming growth factor beta-2 proprotein precursor [Gallus gallus] MHCYLLSVFLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISI YNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYPENAIPPSYYSLYFRIVRFDVSAMEKNA SNLVKAEFRVFRLQNSKARVSEQRIELYQVLKSKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWL HHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDYTYSSGDVKALKSNRKKYSGKTPHLL LMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY LWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_001172158.1 transforming growth factor beta-2 isoform X1 [Pan troglodytes] MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_545713.2 transforming growth factor beta-2 proprotein isoform X1 [Canis lupus familiaris] MHYCVLSAFLILHLVTAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSFCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_005216841.1 transforming growth factor beta-2 isoform X1 [Bos taurus] MHYCVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETVCPVVTTPSGSVGSLCSRQSQVFC GYLDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_004013651.1 transforming growth factor beta-2 proprotein isoform X1 [Ovis aries] MHYCVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETVCPVVTTPSGSVGSLCSRQSQVFC GYLDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >NP_001076129.1 transforming growth factor beta-2 proprotein precursor [Oryctolagus cuniculus] MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSYFPSETVCPVVTTPSGSVGSLCARQSQVLC GYLDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQHIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_002809490.1 transforming growth factor beta-2 isoform X1 [Pongo abelii] MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_010704997.1 transforming growth factor beta-2 proprotein [Meleagris gallopavo] MHCYLLSVFLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISI YNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYPENAIPPSYYSLYFRIVRFDVSAMEKNA SNLVKAEFRVFRLQNSKARVSEQRIELYQVLKSKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWL HHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDYTYSSGDVKALKSNRKKYSGKTPHLL LMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY LWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_017915648.1 PREDICTED: transforming growth factor beta-2 isoform X1 [Capra hircus] MHYCVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETVCPVVTTPSGSVGSLCSRQSQVFC GYLDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSADTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_003814181.1 transforming growth factor beta-2 proprotein isoform X1 [Pan paniscus] MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_003999556.1 transforming growth factor beta-2 proprotein isoform X1 [Felis catus] MHYCVLSAFLLLHLVTAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRHSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_004028464.2 transforming growth factor beta-2 proprotein isoform X1 [Gorilla gorilla gorilla] MHYCVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISI YNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETVCPVVTTPSGSVGSLCSRQSQVLC GYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYQILKSKDLTSPTQ RYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAG IDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPL YIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILY YIGKTPKIEQLSNMIVKSCKCS >XP_005500030.1 transforming growth factor beta-2 [Columba livia] MHCYLLSVFLTLDLATVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISI YNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYPENAIPPSYYSLYFRIVRFDVSAMEKNA SNLVKAEFRVFRLQNSKARVSEQRIELYQVLKSKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWL HHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDYTYSSGDVKALKSNRKKYSGKTPHLL LMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY LWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006022407.1 transforming growth factor beta-2 [Alligator sinensis] MPCYLLSLLLSLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISI YNSTRDLLQEKANHRAATCERERSEEEYYAKEVYKIDMLPFYPENAIPPSYYSLYYRIVRFDVSAMEKNA SNLVKAEFRVFRLQNSKARVSEQRIELYQVVKSKELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHEWL HHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSYTYSSGDVKALKSNKKKYSGKTPHL LLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACP YLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006265110.1 PREDICTED: transforming growth factor beta-2 [Alligator mississippiensis] MHCYLLSVLLSLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISI YNSTRDLLQEKANHRAATCERERSEEEYYAKEVYKIDMLPFYPENAIPPSYYSLYYRIVRFDVSAMEKNA SNLVKAEFRVFRLQNSKARVSEQRIELYQVVKSKELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHEWL HHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSYTYSSGDVKALKSNKKKYSGKTPHL LLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACP YLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_030249007.1 transforming growth factor beta-2 proprotein [Sparus aurata] MNLCIVSLLLTLDLATVALSLSTCSTLDMDQFKKKRIEAIRGQILSKLKLTSPPEDFPEPEDVSRDIVAI YNSTRDLLQEKANERAATCERQRSEEEYYAKEVHKIDMQPFYPSENVISPTHFNPYFRRLTFDVSSMEKN ASNLVKAELRIFRLQNPGARVSEQRIELYQILGHKDLMSPTQRYIDSKVVRTQTEGEWLSFDVTEAVSEW LNHRDRNNGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSFIHGGDLKAFGRRRHSARAPHLLL MLLPSYRLESQTQSQYKNHRTKRALDAAYCSRNVQDNCCLRSLYIDFKKDLGWRWIHEPKGYEANFCTGA CPYLWSADTQHSKVLGLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMKVKSCKCS >XP_043341913.1 transforming growth factor beta-2 proprotein isoform X2 [Cervus canadensis] MHYCVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQE KASRRAAACERERSDEEYYAKEVYKIDMPPFLPSENAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKAR VPEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIP NKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKTSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLR PLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKI EQLSNMIVKSCKCS >NP_001079195.1 transforming growth factor beta-2 proprotein precursor [Xenopus laevis] MHYYVLFTFLTLDLAPVALSLSTCSALDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPGEVSQDVISIYNSTRDLLQE KANERATSCERERSEDEYYAKEVYKIDMLPYYTSENVIPPSYTTPYFRIVRFDVSSMEKNASNLVKAEFRVFRLMNTKAR VSEQRIELYQILKSKDLASPTQRYIDSKVVKTRAEGEWLSFDVTEAVNEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIP NKSEELETRFAGIDDAYMYAGGDSKSKTGRKKHTGRTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRP LYIDFKKDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLDSLTILYYIGNKPKIE QLSNMIVKSCKCS >KAB0343827.1 hypothetical protein FD754_020753 [Muntiacus muntjak] MCVKDQIIEAKKDAVHEPGERRVFGCQNFKGKKIHGQTACYAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQ NPKARVPEQRIELYQVILFGLFEWTMNRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIK STRKKTSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAG ACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_015825679.1 PREDICTED: transforming growth factor beta-3 [Nothobranchius furzeri] MNLGKALLFFLLSSCVTMTFSLSTCTTVDIDHIKKKRVEAVRGQILSKLRMTSPPQATGPSQVPFQVLALYNSTKELIEE LGRDRQQSCGQENTETEYYAKEIYKFNMINGLPENNDLPYCPKGTTSKVFRFNVSILEKNATNLFRAEFRALRIPNPSAK RNEQRIELYQILQKDDPKAKQRYIGGKNVLTKGTPEWVSFDVTETVREWLMYRQTNLGLEISVHCPCHTFRPNGDIIENT NEVLEVKFKGMEGDFEELSRVKKQKEQLYPHLILMMLPPHRLDAHSSSRRRKRALDTNYCFNNYEENCCVRPLYINFRQD LGWRWIHQPEGYYANFCSGPCPYLRSADTTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVK SCKCS >XP_004082378.1 transforming growth factor beta-3 [Oryzias latipes] MNLGKALLLFLLCNCVTMTFSLSTCTTVDIDNIRKKRMEAVRGQILSKLRMTSPPQTAGPTQVPFQVLALYNSTKELIEE LGRDRQQSCGQDSTETEYYAKEIYKFNMINISPENNDLSYCPKGITSKIFRFNVSIMEKNATNLFRAEFRALRIPNSSAK RTEQRIELYQILQKDDPKAKQRYIGGKNVPTKGTPEWISFDVTETVREWLMYRQTNLGLEISVHCPCHTFRPNGDIIENT NEVLEVKFKGVEAEYDDLSRPKKQKEQLYPHLILMMLPPHRLDAHSSSRRRKRALDTNYCFNNYEENCCVRPLYINFRKD LGWKWIHQPEGYYANFCSGPCPYLRSADTTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVK SCKCS >XP_040207370.1 LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [Rana temporaria] MHYYLLSVVLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVSQDVISI YNSTRDLLQEKANHRALLCERERTDDEYYAKEVYKIDFLPPPFPSENAIHPNYYNPYFRIVRFDVSAMEK NISNLVKAEFRVFRLQNPKXRVSEQRIELYQILKSKDLTSPMQRYIDSKVVKTRAEGEWLSFDVTEAIKE WLRHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELETRFAGMDDPFLYPIVDHKNLKPGQKKPNSQTP HLLLMLLPSYRQEPQQANRRKKRALDAAYCFRNVQDNCCLRPLFIDFKRDLGWRWIHEPKGYNANFCAGA CPYLWSSDTQHTRVLGLYNTINPEASASPCCVSQDLESLTILYFVGKTPKIEQLSNMIVKSCKCS >XP_039260065.1 transforming growth factor beta-2 proprotein-like [Styela clava] MHIDKFPVTLLIAVYYLVAPPPTMAGCGVNFEKMKTRRIEAIRGQILSKLGFTQLPRDDKPPGQIPEEVQAMYNRTRDFV EEQARLRRLECEEHDVDYYAQEIVTVYSNKEASGSPEVDFYKNRKLSRQISEFFEFDLEPFKLDTEAITSATLRFYQIPN PVSESGITQQVDLHQLTLPGKEGHSPGRHFLTMRLMDTIGSGWQSFDVTTTIREWARYPHTNLGLEMTVPCPEDDQASQS PTRRSSPRGVREKMEILFAGSNRHMAAGRGDRITDVPVSTTATKDLQPHLVVMMRSPEAQRHHTGKSKRRSKRSLDAEYC FNSNPTETNCCLRELYIDFRKDLKWKWVHAPSGYKANFCAGACPYLWSMDSQHATILSLYKSMNPKASSSPCCVPKELNP LTIMFYNKGRFQVRRLSDMVLMSCKCS >XP_030855505.1 transforming growth factor beta-2 proprotein-like [Strongylocentrotus purpuratus] MFSSSSTSSSIRCCLAASWLGLAVLSLTFDGLGAGGQCKFDLQEYQDRRIAAIKGQILSKLGLTALPTDDGPEDVPKDIL DLFNQTVTLLEEKYENEREQCKGLSGGSDDYFAQLPILYGIVETDIEKDIGNYATVKRLSKFFRFDLTSFEEDSQGDEVT EAEFRLYQVPNEMKDTEQQIDLFQLITSYNSTEEPTRRFLTSWTVSTTREGWLAHDVTDVVREWVADPETNLGFELNLNC GDYLLGPTTTTPASIPKDQHKLHVLFADPRGTFPSMDNGRGDGNPRGEGFPSINHPRLVVMTPANHSRGSESNSVRKRRS TSYSGSQCDQNSPNCCLRPLVINFRRDLKWNWIRQPRNYSPNFCAGSCPYILSADTSHASVLSLYKHLNPDASPSPCCSP QTFKPLTILFYNRGRPEIRQLNNMIIETCRCS >XP_038073348.1 transforming growth factor beta-2 proprotein-like [Patiria miniata] MVVIGTGCTIWLPTTRRRAVRDIIVRRPLTCRWQKMGTLVPPRMTSLHLTVMCLALWALLQAATGGSGQCKLNFQEYQNR RRSAIQAQILSKLGLTAPPTDIGPEEVPEDVIAMYNETVRILEERREMMESVCQQAQSEEYFAKVPKVYPLDKKVNPDID NYQTMKLKQSKFFRFDLSSYTADVNSDEVFEAELRLYQLPNAMKEEEQHIDVYQLIPSPSNGNPGRKHVFSTVLDTTTEG WIKIDVTQAVREWVSIPGSNLGIEVTTPCDDTIHVLFAHPKGTMPSVKMPTRGDQQMADMSPREQHPRLIVLAPANDTIG SNSGTGHRSRRSTSTYGQNTCSDQTQPSCCLRQFYVNFKRHLGWGWIRQPKGYYPNYCAGSCSYVNGSVWNAQTHHGSVL DTYRRLNPDASPSPCCSPRSFKPLHILFYDKGRPLFRELPNAIVTSCQCS >XP_031564885.1 transforming growth factor beta-3 proprotein-like [Actinia tenebrosa] MFQQRSLSRYFCWILMAISLATHVVLVNGKTRLGRLKESRLLAVRGQILTKLGLTAPPIDKTQRNTNKEDLEAYQAVVEE SEKQHGQEFECTRHLDRSNYFAKRVVRLPLATRFGRTIQFTDATTNKLWIADVNTLTFNTDQLNGESHIERAELRLKPES LSTITPPGSNLEICLNAQPQLSRESNDTLFRECSQVLHSRFVTAHENALISIVITCIIKDWIFRSVSNNGIKIILKNQDT EKEGKSRDESLGSGPFVLVWYIPNDRYEIEKRRRKRRALDSAFCNKRPKEKRCCLRPLYIDFQRDLRWNWIHAPLGFHAN YCKGKCPFMWSMNNQTHHTSIMALFNSLNPDAPSEPCCVAQSYKPLVILYYDKGKPKIEELSNMVVSSCTCI
Mafft alignment of selected proteins >sp|P61812|TGFB2_HUMAN Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 PE=1 SV=1 MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSE---------------- ------------NAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >sp|P61812-2|TGFB2_HUMAN Isoform B of Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >tr|Q7SZV4|Q7SZV4_DANRE Transforming growth factor beta OS=Danio rerio OX=7955 GN=tgfb2 PE=2 SV=1 MNL---------------------------------------------YVLSLLLLLDLA AVAVSLSTCSTVDMDQFKKKRIEAIRGQILSKLKLSSPPEIYPEPEEVSRGIIAIYNSTR DLLQEKANERAATCE-RQRSEEEYYAKEVHKID---MQPFYPSE---------------- ------------NVILSQHYYPYFRRLMFDVSSMEKNA------SNLVKAQLRI----FR LQNPKARVF-EQRIELY-QV-LGH-KDLTSPTQRYINSKVVRTRTEGEWLSFDVTEAVSE WLLHRDRNKGFKISLHCPC---CTFVPSNNY--IIPNKSEELETRFAGIDDSFVN-GGDL -KMFK--KRRHSGQSPHLLLMLLPSYRLESQHKS----HRQKRALDTAFCSRN--VQDNR CLRSLYIDFKKDLGWRWIHEPKGYNANFCAGACPY----LWSAD--TQHSNILGLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_033393.2 transforming growth factor beta-2 proprotein isoform 1 preproprotein [Mus musculus] MHY---------------------------------------------CVLSTFLLLHLV PVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSHLPSE---------------- ------------NAIPPTFYRPYFRIVRFDVSTMEKNA------SNLVKAEFRV----FR LQNPKARVA-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYASGDQ -KTIKSTRKKTSGKTPHLLLMLLPSYRLESQQSS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHTKVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS >NP_112393.2 transforming growth factor beta-2 proprotein precursor [Rattus norvegicus] MHY---------------------------------------------CVLRTFLLLHLV PVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSHFPSETVCPVVTTSSGSVGSF CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSTMEKNA------SNLVKAEFRV----FR LQNPKARVA-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFIPSNNY--IIPNKSQELEARFAGIDGTSTYASGDQ -KTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSS----RRRKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHTKVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS >XP_020919952.1 transforming growth factor beta-2 isoform X1 [Sus scrofa] MHY---------------------------------------------CVLSAFLLLHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVA-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001026216.2 transforming growth factor beta-2 proprotein precursor [Gallus gallus] MHC---------------------------------------------YLLSVFLTLDLA AVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTR DLLQEKANHRAATCE-RERSDEEYYAKEVYKID---MQPFYP-E---------------- ------------NAIPPSYYSLYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNSKARVS-EQRIELY-QV-LKS-KELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHE WLHHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDD-YTYSSGDV -KALKSNRKKYSGKTPHLLLMLLPSYRLESQQPS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_001172158.1 transforming growth factor beta-2 isoform X1 [Pan troglodytes] MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_545713.2 transforming growth factor beta-2 proprotein isoform X1 [Canis lupus familiaris] MHY---------------------------------------------CVLSAFLILHLV TAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSF CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_005216841.1 transforming growth factor beta-2 isoform X1 [Bos taurus] MHY---------------------------------------------CVLSAFLLLHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSFLPSETVCPVVTTPSGSVGSL CSRQSQVFCGYLDAIPPTFYRPYFRIVRFDVSSMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_004013651.1 transforming growth factor beta-2 proprotein isoform X1 [Ovis aries] MHY---------------------------------------------CVLSAFLLLHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSFLPSETVCPVVTTPSGSVGSL CSRQSQVFCGYLDAIPPTFYRPYFRIVRFDVSSMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001076129.1 transforming growth factor beta-2 proprotein precursor [Oryctolagus cuniculus] MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSYFPSETVCPVVTTPSGSVGSL CARQSQVLCGYLDAIPPTFYRPYFRIVRFDVSTMEKNA------SNLVKAEFRV----FR LQNPKARVA-EQHIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_002809490.1 transforming growth factor beta-2 isoform X1 [Pongo abelii] MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_010704997.1 transforming growth factor beta-2 proprotein [Meleagris gallopavo] MHC---------------------------------------------YLLSVFLTLDLA AVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTR DLLQEKANHRAATCE-RERSDEEYYAKEVYKID---MQPFYP-E---------------- ------------NAIPPSYYSLYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNSKARVS-EQRIELY-QV-LKS-KELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHE WLHHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDD-YTYSSGDV -KALKSNRKKYSGKTPHLLLMLLPSYRLESQQPS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_017915648.1 PREDICTED: transforming growth factor beta-2 isoform X1 [Capra hircus] MHY---------------------------------------------CVLSAFLLLHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPSFLPSETVCPVVTTPSGSVGSL CSRQSQVFCGYLDAIPPTFYRPYFRIVRFDVSSMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSAD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_003814181.1 transforming growth factor beta-2 proprotein isoform X1 [Pan paniscus] MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_003999556.1 transforming growth factor beta-2 proprotein isoform X1 [Felis catus] MHY---------------------------------------------CVLSAFLLLHLV TAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRHSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_004028464.2 transforming growth factor beta-2 proprotein isoform X1 [Gorilla gorilla gorilla] MHY---------------------------------------------CVLSAFLILHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFFPSETVCPVVTTPSGSVGSL CSRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_005500030.1 transforming growth factor beta-2 [Columba livia] MHC---------------------------------------------YLLSVFLTLDLA TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTR DLLQEKANHRAATCE-RERSDEEYYAKEVYKID---MQPFYP-E---------------- ------------NAIPPSYYSLYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNSKARVS-EQRIELY-QV-LKS-KELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHE WLHHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDD-YTYSSGDV -KALKSNRKKYSGKTPHLLLMLLPSYRLESQQPS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006022407.1 transforming growth factor beta-2 [Alligator sinensis] MPC---------------------------------------------YLLSLLLSLDLA AVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTR DLLQEKANHRAATCE-RERSEEEYYAKEVYKID---MLPFYP-E---------------- ------------NAIPPSYYSLYYRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNSKARVS-EQRIELY-QV-VKS-KELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDDSYTYSSGDV -KALKSNKKKYSGKTPHLLLMLLPSYRLESQQPS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006265110.1 PREDICTED: transforming growth factor beta-2 [Alligator mississippiensis] MHC---------------------------------------------YLLSVLLSLDLA AVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTR DLLQEKANHRAATCE-RERSEEEYYAKEVYKID---MLPFYP-E---------------- ------------NAIPPSYYSLYYRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNSKARVS-EQRIELY-QV-VKS-KELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDDSYTYSSGDV -KALKSNKKKYSGKTPHLLLMLLPSYRLESQQPS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_030249007.1 transforming growth factor beta-2 proprotein [Sparus aurata] MNL---------------------------------------------CIVSLLLTLDLA TVALSLSTCSTLDMDQFKKKRIEAIRGQILSKLKLTSPPEDFPEPEDVSRDIVAIYNSTR DLLQEKANERAATCE-RQRSEEEYYAKEVHKID---MQPFYPSE---------------- ------------NVISPTHFNPYFRRLTFDVSSMEKNA------SNLVKAELRI----FR LQNPGARVS-EQRIELY-QI-LGH-KDLMSPTQRYIDSKVVRTQTEGEWLSFDVTEAVSE WLNHRDRNNGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDDSFIH-GGDL -KAFG--RRRHSARAPHLLLMLLPSYRLESQTQSQYKNHRTKRALDAAYCSRN--VQDNC CLRSLYIDFKKDLGWRWIHEPKGYEANFCTGACPY----LWSAD--TQHSKVLGLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMKVKSCKCS >XP_043341913.1 transforming growth factor beta-2 proprotein isoform X2 [Cervus canadensis] MHY---------------------------------------------CVLSAFLLLHLV TVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTR DLLQEKASRRAAACE-RERSDEEYYAKEVYKID---MPPFLPSE---------------- ------------NAIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QI-LKS-KDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHE WLHHKDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKTSGKSPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001079195.1 transforming growth factor beta-2 proprotein precursor [Xenopus laevis] MHY---------------------------------------------YVLFTFLTLDLA PVALSLSTCSALDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPGEVSQDVISIYNSTR DLLQEKANERATSCE-RERSEDEYYAKEVYKID---MLPYYTSE---------------- ------------NVIPPSYTTPYFRIVRFDVSSMEKNA------SNLVKAEFRV----FR LMNTKARVS-EQRIELY-QI-LKS-KDLASPTQRYIDSKVVKTRAEGEWLSFDVTEAVNE WLHHKDRNLGFKISLHCPC---CTFIPSNNY--IIPNKSEELETRFAGIDDAYMYAGGDS -KS-KTGRKKHTGRTPHLLLMLLPSYRLESQQSS----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKKDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLDSLTILYYIGNKPKIEQLSNMIVKSCKCS >KAB0343827.1 hypothetical protein FD754_020753 [Muntiacus muntjak] MCV--------------------------------------------------------- ---------------------------------------KD------------QIIEAKK DAVHEPGERRVFGCQ-NFKGKKIHGQTACY------------------------------ -------------AIPPTFYRPYFRIVRFDVSAMEKNA------SNLVKAEFRV----FR LQNPKARVP-EQRIELY-QV---------------------------------ILFGLFE WT--MNRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELEARFAGIDGTSTYTSGDQ -KTIKSTRKKTSGKSPHLLLMLLPSYRLESQQSN----RRKKRALDAAYCFRN--VQDNC CLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPY----LWSSD--TQHSRVLSLYNTIN PEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_015825679.1 PREDICTED: transforming growth factor beta-3 [Nothobranchius furzeri] MNL--------------------------------------------GKALLFFLLSSCV TMTFSLSTCTTVDIDHIKKKRVEAVRGQILSKLRMTSPPQA-TGPSQVPFQVLALYNSTK ELIEELGRDRQQSCG-QENTETEYYAKEIYKFN---MINGLPEN---------------- ------------NDLPYCPKGTTSKVFRFNVSILEKNA------TNLFRAEFRA----LR IPNPSAKRN-EQRIELY-QI-LQ--KDDPKAKQRYIGGKNVLTKGTPEWVSFDVTETVRE WLMYRQTNLGLEISVHCPC---HTFRP-NGD--IIENTNEVLEVKFKGME-------GDF -EELSRVKKQKEQLYPHLILMMLPPHRLDAHSSS----RRRKRALDTNYCFNN--YEENC CVRPLYINFRQDLGWRWIHQPEGYYANFCSGPCPY----LRSAD--TTHSSLLSLYNTLN PEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVKSCKCS >XP_004082378.1 transforming growth factor beta-3 [Oryzias latipes] MNL--------------------------------------------GKALLLFLLCNCV TMTFSLSTCTTVDIDNIRKKRMEAVRGQILSKLRMTSPPQT-AGPTQVPFQVLALYNSTK ELIEELGRDRQQSCG-QDSTETEYYAKEIYKFN---MINISPEN---------------- ------------NDLSYCPKGITSKIFRFNVSIMEKNA------TNLFRAEFRA----LR IPNSSAKRT-EQRIELY-QI-LQ--KDDPKAKQRYIGGKNVPTKGTPEWISFDVTETVRE WLMYRQTNLGLEISVHCPC---HTFRP-NGD--IIENTNEVLEVKFKGVE-------AEY -DDLSRPKKQKEQLYPHLILMMLPPHRLDAHSSS----RRRKRALDTNYCFNN--YEENC CVRPLYINFRKDLGWKWIHQPEGYYANFCSGPCPY----LRSAD--TTHSSLLSLYNTLN PEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVKSCKCS >XP_040207370.1 LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [Rana temporaria] MHY---------------------------------------------YLLSVVLTLDLA AVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVSQDVISIYNSTR DLLQEKANHRALLCE-RERTDDEYYAKEVYKIDF--LPPPFPSE---------------- ------------NAIHPNYYNPYFRIVRFDVSAMEKNI------SNLVKAEFRV----FR LQNPKXRVS-EQRIELY-QI-LKS-KDLTSPMQRYIDSKVVKTRAEGEWLSFDVTEAIKE WLRHRDRNLGFKISLHCPC---CTFVPSNNY--IIPNKSEELETRFAGMDDPFLYPIVDH -KNLKPGQKKPNSQTPHLLLMLLPSYRQEPQQAN----RRKKRALDAAYCFRN--VQDNC CLRPLFIDFKRDLGWRWIHEPKGYNANFCAGACPY----LWSSD--TQHTRVLGLYNTIN PEASASPCCVSQDLESLTILYFVGKTPKIEQLSNMIVKSCKCS >XP_039260065.1 transforming growth factor beta-2 proprotein-like [Styela clava] MHI------------------------------------------DKFPVTLLIAVYYLV APPPTMAG-CGVNFEKMKTRRIEAIRGQILSKLGFTQLPRDDKPPGQIPEEVQAMYNRTR DFVEEQARLRRLECE---EHDVDYYAQEIVTVYSNKEASGSPEVD--------------- ------------FYKNRKLSRQISEFFEFDLEPFKLDT------EAITSATLRF----YQ IPNPVSESGITQQVDLH-QLTLPG-KEGHSPGRHFLTMRLMDTIGSG-WQSFDVTTTIRE WARYPHTNLGLEMTVPCPEDDQASQSPTRRS--SPRGVREKMEILFAGSNRHMAAGRGDR ITDVPVSTTATKDLQPHLVVMMRSPEAQRHHTGK-SK-RRSKRSLDAEYCFNSNPTETNC CLRELYIDFRKDLKWKWVHAPSGYKANFCAGACPY----LWSMD--SQHATILSLYKSMN PKASSSPCCVPKELNPLTIMFYNKGRFQVRRLSDMVLMSCKCS >XP_030855505.1 transforming growth factor beta-2 proprotein-like [Strongylocentrotus purpuratus] MFSSSSTSS---------SIR-----------------------CCLAASWLGLAVLSLT FDGLGAGGQCKFDLQEYQDRRIAAIKGQILSKLGLTALPTD-DGPEDVPKDILDLFNQTV TLLEEKYENEREQCKGLSGGSDDYFAQLPILYGI-VETDIEKDIG--------------- ------------NYATVK---RLSKFFRFDLTSFEEDSQ----GDEVTEAEFRL----YQ VPN-EMKDT-EQQIDLF-QL-ITSYNSTEEPTRRFLTSWTVSTTREG-WLAHDVTDVVRE WVADPETNLGFELNLNCGD---YLLGPTTTTPASIPKDQHKLHVLFADPRGTFPSMDNGR GDGNPRGEGFPSINHPRLVVMTPANHSRGSESNS-VR-KRRSTSYSGSQCDQN---SPNC CLRPLVINFRRDLKWNWIRQPRNYSPNFCAGSCPY----ILSAD--TSHASVLSLYKHLN PDASPSPCCSPQTFKPLTILFYNRGRPEIRQLNNMIIETCRCS >XP_038073348.1 transforming growth factor beta-2 proprotein-like [Patiria miniata] MVVIGTGCTIWLPTTRRRAVRDIIVRRPLTCRWQKMGTLVPPRMTSLHLTVMCLALWALL QAATGGSGQCKLNFQEYQNRRRSAIQAQILSKLGLTAPPTD-IGPEEVPEDVIAMYNETV RILEERREMMESVCQ--QAQSEEYFAKVPKVYPL--DKKVNPDID--------------- ------------NYQTMKL--KQSKFFRFDLSSYTADVN----SDEVFEAELRL----YQ LPN-AMKEE-EQHIDVY-QL-IPS-PSNGNPGRKHVFSTVLDTTTEG-WIKIDVTQAVRE WVSIPGSNLGIEVTTPCDD---------------------TIHVLFAHPKGTMPSVKMPT RGDQQMADMSPREQHPRLIVLAPANDTIGSNSGTGHRSRRSTSTYGQNTCSDQ--TQPSC CLRQFYVNFKRHLGWGWIRQPKGYYPNYCAGSCSYVNGSVWNAQ--THHGSVLDTYRRLN PDASPSPCCSPRSFKPLHILFYDKGRPLFRELPNAIVTSCQCS >XP_031564885.1 transforming growth factor beta-3 proprotein-like [Actinia tenebrosa] MFQQRS--------------------------------------LSRYFCWILMAI-SLA THVVLVNG--KTRLGRLKESRLLAVRGQILTKLGLTAPPID-KTQRNTNKEDLEAYQAVV EE-SEKQHGQEFECT-RHLDRSNYFAKRVVRLP---LATRFGRT---------------- ------------IQFTDA---TTNKLWIADVNTLTFNTDQLNGESHIERAELRLKPESLS TITPPGSNL-EICLNAQPQLSRESNDTLFRECSQVLHSRFVTAHENA-LISIVITCIIKD WIFRSVSNNGIKI--------------------ILKNQDTEKEGK--------------- ------SRDESLGSGPFVLVWYIPNDRYEIEKR-----RRKRRALDSAFCNKR-PKEKRC CLRPLYIDFQRDLRWNWIHAPLGFHANYCKGKCPF----MWSMNNQTHHTSIMALFNSLN PDAPSEPCCVAQSYKPLVILYYDKGKPKIEELSNMVVSSCTCI
BMGE Cleaned alignment of selected proteins >sp|P61812|TGFB2_HUMAN Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 PE=1 SV=1 CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSE-NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >sp|P61812-2|TGFB2_HUMAN Isoform B of Transforming growth factor beta-2 proprotein OS=Homo sapiens OX=9606 GN=TGFB2 CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >tr|Q7SZV4|Q7SZV4_DANRE Transforming growth factor beta OS=Danio rerio OX=7955 GN=tgfb2 PE=2 SV=1 YVLSLLLLLDLAAVAVSLSTCSTVDMDQFKKKRIEAIRGQILSKLKLSSPPEIYPEPEEVSRGIIAIYNSTRDLLQEKANERAATCERQRSEEEYYAKEVHKIDMQPFYPSE-NVILSQHYYPYFRRLMFDVSSMEKNASNLVKAQLRIFRLQNPKARVFEQRIELYKDLTSPTQRYINSKVVRTRTEGEWLSFDVTEAVSEWLLHRDRNKGFKISLHCPCCTFVPSNNYIIPNKSEELETRFAGIDDSFVN-GGDLKMFK--KRRHSGQSPHLLLMLLPSYRLESQHKSHRQKRALDTAFCSRNVQDNRCLRSLYIDFKKDLGWRWIHEPKGYNANFCAGACPYLWSADTQHSNILGLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_033393.2 transforming growth factor beta-2 proprotein isoform 1 preproprotein [Mus musculus] CVLSTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHLPSE-NAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVQEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYASGDQKTIKSTRKKTSGKTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS >NP_112393.2 transforming growth factor beta-2 proprotein precursor [Rattus norvegicus] CVLRTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHFPSETDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSQELEARFAGIDGTSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS >XP_020919952.1 transforming growth factor beta-2 isoform X1 [Sus scrofa] CVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001026216.2 transforming growth factor beta-2 proprotein precursor [Gallus gallus] YLLSVFLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYP-E-NAIPPSYYSLYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDD-YTYSSGDVKALKSNRKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_001172158.1 transforming growth factor beta-2 isoform X1 [Pan troglodytes] CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_545713.2 transforming growth factor beta-2 proprotein isoform X1 [Canis lupus familiaris] CVLSAFLILHLVTAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_005216841.1 transforming growth factor beta-2 isoform X1 [Bos taurus] CVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_004013651.1 transforming growth factor beta-2 proprotein isoform X1 [Ovis aries] CVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001076129.1 transforming growth factor beta-2 proprotein precursor [Oryctolagus cuniculus] CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSYFPSETDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQHIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_002809490.1 transforming growth factor beta-2 isoform X1 [Pongo abelii] CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_010704997.1 transforming growth factor beta-2 proprotein [Meleagris gallopavo] YLLSVFLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYP-E-NAIPPSYYSLYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDD-YTYSSGDVKALKSNRKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_017915648.1 PREDICTED: transforming growth factor beta-2 isoform X1 [Capra hircus] CVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSFLPSETDAIPPTFYRPYFRIVRFDVSSMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSADTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_003814181.1 transforming growth factor beta-2 proprotein isoform X1 [Pan paniscus] CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_003999556.1 transforming growth factor beta-2 proprotein isoform X1 [Felis catus] CVLSAFLLLHLVTAALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_004028464.2 transforming growth factor beta-2 proprotein isoform X1 [Gorilla gorilla gorilla] CVLSAFLILHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFFPSETDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPHLLLMLLPSYRLESQQTNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_005500030.1 transforming growth factor beta-2 [Columba livia] YLLSVFLTLDLATVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSDEEYYAKEVYKIDMQPFYP-E-NAIPPSYYSLYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYKELSSPGQRYIDSKVVKTRAEGEWLSFDVTEAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDD-YTYSSGDVKALKSNRKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006022407.1 transforming growth factor beta-2 [Alligator sinensis] YLLSLLLSLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSEEEYYAKEVYKIDMLPFYP-E-NAIPPSYYSLYYRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYKELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSYTYSSGDVKALKSNKKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_006265110.1 PREDICTED: transforming growth factor beta-2 [Alligator mississippiensis] YLLSVLLSLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPDEYPEPEEVPPEVISIYNSTRDLLQEKANHRAATCERERSEEEYYAKEVYKIDMLPFYP-E-NAIPPSYYSLYYRIVRFDVSAMEKNASNLVKAEFRVFRLQNSKARVSEQRIELYKELPSPGQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSYTYSSGDVKALKSNKKKYSGKTPHLLLMLLPSYRLESQQPSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYHANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_030249007.1 transforming growth factor beta-2 proprotein [Sparus aurata] CIVSLLLTLDLATVALSLSTCSTLDMDQFKKKRIEAIRGQILSKLKLTSPPEDFPEPEDVSRDIVAIYNSTRDLLQEKANERAATCERQRSEEEYYAKEVHKIDMQPFYPSE-NVISPTHFNPYFRRLTFDVSSMEKNASNLVKAELRIFRLQNPGARVSEQRIELYKDLMSPTQRYIDSKVVRTQTEGEWLSFDVTEAVSEWLNHRDRNNGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDDSFIH-GGDLKAFG--RRRHSARAPHLLLMLLPSYRLESQTQSHRTKRALDAAYCSRNVQDNCCLRSLYIDFKKDLGWRWIHEPKGYEANFCTGACPYLWSADTQHSKVLGLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMKVKSCKCS >XP_043341913.1 transforming growth factor beta-2 proprotein isoform X2 [Cervus canadensis] CVLSAFLLLHLVTVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPEEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPPFLPSE-NAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELYKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKTSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >NP_001079195.1 transforming growth factor beta-2 proprotein precursor [Xenopus laevis] YVLFTFLTLDLAPVALSLSTCSALDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPGEVSQDVISIYNSTRDLLQEKANERATSCERERSEDEYYAKEVYKIDMLPYYTSE-NVIPPSYTTPYFRIVRFDVSSMEKNASNLVKAEFRVFRLMNTKARVSEQRIELYKDLASPTQRYIDSKVVKTRAEGEWLSFDVTEAVNEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSEELETRFAGIDDAYMYAGGDSKS-KTGRKKHTGRTPHLLLMLLPSYRLESQQSSRRKKRALDAAYCFRNVQDNCCLRPLYIDFKKDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLDSLTILYYIGNKPKIEQLSNMIVKSCKCS >KAB0343827.1 hypothetical protein FD754_020753 [Muntiacus muntjak] ---------------------------------------------------KD------------QIIEAKKDAVHEPGERRVFGCQNFKGKKIHGQTACY-------------AIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRVFRLQNPKARVPEQRIELY----------------------------ILFGLFEWT--MNRNLGFKISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKTSGKSPHLLLMLLPSYRLESQQSNRRKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS >XP_015825679.1 PREDICTED: transforming growth factor beta-3 [Nothobranchius furzeri] KALLFFLLSSCVTMTFSLSTCTTVDIDHIKKKRVEAVRGQILSKLRMTSPPQA-TGPSQVPFQVLALYNSTKELIEELGRDRQQSCGQENTETEYYAKEIYKFNMINGLPEN-NDLPYCPKGTTSKVFRFNVSILEKNATNLFRAEFRALRIPNPSAKRNEQRIELYKDDPKAKQRYIGGKNVLTKGTPEWVSFDVTETVREWLMYRQTNLGLEISVHCPCHTFRP-NGDIIENTNEVLEVKFKGME-------GDFEELSRVKKQKEQLYPHLILMMLPPHRLDAHSSSRRRKRALDTNYCFNNYEENCCVRPLYINFRQDLGWRWIHQPEGYYANFCSGPCPYLRSADTTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVKSCKCS >XP_004082378.1 transforming growth factor beta-3 [Oryzias latipes] KALLLFLLCNCVTMTFSLSTCTTVDIDNIRKKRMEAVRGQILSKLRMTSPPQT-AGPTQVPFQVLALYNSTKELIEELGRDRQQSCGQDSTETEYYAKEIYKFNMINISPEN-NDLSYCPKGITSKIFRFNVSIMEKNATNLFRAEFRALRIPNSSAKRTEQRIELYKDDPKAKQRYIGGKNVPTKGTPEWISFDVTETVREWLMYRQTNLGLEISVHCPCHTFRP-NGDIIENTNEVLEVKFKGVE-------AEYDDLSRPKKQKEQLYPHLILMMLPPHRLDAHSSSRRRKRALDTNYCFNNYEENCCVRPLYINFRKDLGWKWIHQPEGYYANFCSGPCPYLRSADTTHSSLLSLYNTLNPEASASPCCVPQDLEPLTILYYVGRSPKVEQLSNMVVKSCKCS >XP_040207370.1 LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein [Rana temporaria] YLLSVVLTLDLAAVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLNSPPEDYPEPEEVSQDVISIYNSTRDLLQEKANHRALLCERERTDDEYYAKEVYKIDLPPPFPSE-NAIHPNYYNPYFRIVRFDVSAMEKNISNLVKAEFRVFRLQNPKXRVSEQRIELYKDLTSPMQRYIDSKVVKTRAEGEWLSFDVTEAIKEWLRHRDRNLGFKISLHCPCCTFVPSNNYIIPNKSEELETRFAGMDDPFLYPIVDHKNLKPGQKKPNSQTPHLLLMLLPSYRQEPQQANRRKKRALDAAYCFRNVQDNCCLRPLFIDFKRDLGWRWIHEPKGYNANFCAGACPYLWSSDTQHTRVLGLYNTINPEASASPCCVSQDLESLTILYFVGKTPKIEQLSNMIVKSCKCS >XP_039260065.1 transforming growth factor beta-2 proprotein-like [Styela clava] PVTLLIAVYYLVAPPPTMAG-CGVNFEKMKTRRIEAIRGQILSKLGFTQLPRDDKPPGQIPEEVQAMYNRTRDFVEEQARLRRLECE--EHDVDYYAQEIVTVYEASGSPEVDFYKNRKLSRQISEFFEFDLEPFKLDTEAITSATLRFYQIPNPVSESGTQQVDLHKEGHSPGRHFLTMRLMDTIGSG-WQSFDVTTTIREWARYPHTNLGLEMTVPCPEASQSPTRRSSPRGVREKMEILFAGSNRHMAAGRGDRTDVPVSTTATKDLQPHLVVMMRSPEAQRHHTGKRRSKRSLDAEYCFNSTETNCCLRELYIDFRKDLKWKWVHAPSGYKANFCAGACPYLWSMDSQHATILSLYKSMNPKASSSPCCVPKELNPLTIMFYNKGRFQVRRLSDMVLMSCKCS >XP_030855505.1 transforming growth factor beta-2 proprotein-like [Strongylocentrotus purpuratus] ASWLGLAVLSLTFDGLGAGGQCKFDLQEYQDRRIAAIKGQILSKLGLTALPTD-DGPEDVPKDILDLFNQTVTLLEEKYENEREQCKLSGGSDDYFAQLPILYGETDIEKDIGNYATVK---RLSKFFRFDLTSFEEDSDEVTEAEFRLYQVPN-EMKDTEQQIDLFNSTEEPTRRFLTSWTVSTTREG-WLAHDVTDVVREWVADPETNLGFELNLNCGDYLLGPTTTTSIPKDQHKLHVLFADPRGTFPSMDNGRDGNPRGEGFPSINHPRLVVMTPANHSRGSESNSKRRSTSYSGSQCDQN-SPNCCLRPLVINFRRDLKWNWIRQPRNYSPNFCAGSCPYILSADTSHASVLSLYKHLNPDASPSPCCSPQTFKPLTILFYNRGRPEIRQLNNMIIETCRCS >XP_038073348.1 transforming growth factor beta-2 proprotein-like [Patiria miniata] LTVMCLALWALLQAATGGSGQCKLNFQEYQNRRRSAIQAQILSKLGLTAPPTD-IGPEEVPEDVIAMYNETVRILEERREMMESVCQ-QAQSEEYFAKVPKVYPDKKVNPDIDNYQTMKL--KQSKFFRFDLSSYTADVDEVFEAELRLYQLPN-AMKEEEQHIDVYPSNGNPGRKHVFSTVLDTTTEG-WIKIDVTQAVREWVSIPGSNLGIEVTTPCDD----------------TIHVLFAHPKGTMPSVKMPTGDQQMADMSPREQHPRLIVLAPANDTIGSNSGTRRSTSTYGQNTCSDQTQPSCCLRQFYVNFKRHLGWGWIRQPKGYYPNYCAGSCSYVWNAQTHHGSVLDTYRRLNPDASPSPCCSPRSFKPLHILFYDKGRPLFRELPNAIVTSCQCS >XP_031564885.1 transforming growth factor beta-3 proprotein-like [Actinia tenebrosa] FCWILMAI-SLATHVVLVNG--KTRLGRLKESRLLAVRGQILTKLGLTAPPID-KTQRNTNKEDLEAYQAVVEE-SEKQHGQEFECTRHLDRSNYFAKRVVRLPLATRFGRT-IQFTDA---TTNKLWIADVNTLTFNTSHIERAELRLLSTITPPGSNLEICLNAQDTLFRECSQVLHSRFVTAHENA-LISIVITCIIKDWIFRSVSNNGIKI---------------ILKNQDTEKEGK--------------------SRDESLGSGPFVLVWYIPNDRYEIEKR-RRKRRALDSAFCNKRKEKRCCLRPLYIDFQRDLRWNWIHAPLGFHANYCKGKCPFMWSMNTHHTSIMALFNSLNPDAPSEPCCVAQSYKPLVILYYDKGKPKIEELSNMVVSSCTCI
PhyML tree of selected proteins (((XP_003814181_1_transforming_growth_factor_beta_2_proprotein_isoform_X1__Pan_paniscus_:0.00000001,(XP_001172158_1_transforming_growth_factor_beta_2_isoform_X1__Pan_troglodytes_:0.00000001,(sp_P61812_2_TGFB2_HUMAN_Isoform_B_of_Transforming_growth_factor_beta_2_proprotein_OS_Homo_sapiens_OX_9606_GN_TGFB2:0.00000001,XP_004028464_2_transforming_growth_factor_beta_2_proprotein_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0,(XP_002809490_1_transforming_growth_factor_beta_2_isoform_X1__Pongo_abelii_:0.00265268,(((XP_020919952_1_transforming_growth_factor_beta_2_isoform_X1__Sus_scrofa_:0.00000001,(NP_001076129_1_transforming_growth_factor_beta_2_proprotein_precursor__Oryctolagus_cuniculus_:0.00546831,(NP_112393_2_transforming_growth_factor_beta_2_proprotein_precursor__Rattus_norvegicus_:0.0117013,NP_033393_2_transforming_growth_factor_beta_2_proprotein_isoform_1_preproprotein__Mus_musculus_:0.00980339):0.02709018):0.0078452):0.00265681,((XP_043341913_1_transforming_growth_factor_beta_2_proprotein_isoform_X2__Cervus_canadensis_:0.00000001,KAB0343827_1_hypothetical_protein_FD754_020753__Muntiacus_muntjak_:0.18279377):0.00537827,((XP_005216841_1_transforming_growth_factor_beta_2_isoform_X1__Bos_taurus_:0.00000001,XP_004013651_1_transforming_growth_factor_beta_2_proprotein_isoform_X1__Ovis_aries_:0.00000001):0.00000001,(XP_017915648_1_PREDICTED__transforming_growth_factor_beta_2_isoform_X1__Capra_hircus_:0.00000001,((XP_031564885_1_transforming_growth_factor_beta_3_proprotein_like__Actinia_tenebrosa_:2.12702826,(XP_039260065_1_transforming_growth_factor_beta_2_proprotein_like__Styela_clava_:0.91302409,(XP_038073348_1_transforming_growth_factor_beta_2_proprotein_like__Patiria_miniata_:0.76547866,XP_030855505_1_transforming_growth_factor_beta_2_proprotein_like__Strongylocentrotus_purpuratus_:0.49601759):0.72443616):0.45728437):0.348789,(XP_004082378_1_transforming_growth_factor_beta_3__Oryzias_latipes_:0.0553597,XP_015825679_1_PREDICTED__transforming_growth_factor_beta_3__Nothobranchius_furzeri_:0.03710379):0.51536733):0.42135732):0.00263922):0.00532638):0.00533148):0.00000001,(XP_003999556_1_transforming_growth_factor_beta_2_proprotein_isoform_X1__Felis_catus_:0.00000001,XP_545713_2_transforming_growth_factor_beta_2_proprotein_isoform_X1__Canis_lupus_familiaris_:0.00266032):0.00266145):0.00532523):0):0.00266284,sp_P61812_TGFB2_HUMAN_Transforming_growth_factor_beta_2_proprotein_OS_Homo_sapiens_OX_9606_GN_TGFB2_PE_1_SV_1:0.00000001,(((XP_040207370_1_LOW_QUALITY_PROTEIN__transforming_growth_factor_beta_2_proprotein__Rana_temporaria_:0.13355037,NP_001079195_1_transforming_growth_factor_beta_2_proprotein_precursor__Xenopus_laevis_:0.08863949):0.01698999,(tr_Q7SZV4_Q7SZV4_DANRE_Transforming_growth_factor_beta_OS_Danio_rerio_OX_7955_GN_tgfb2_PE_2_SV_1:0.08618993,XP_030249007_1_transforming_growth_factor_beta_2_proprotein__Sparus_aurata_:0.06504173):0.13000156):0.02793398,(XP_005500030_1_transforming_growth_factor_beta_2__Columba_livia_:0.00000001,((NP_001026216_2_transforming_growth_factor_beta_2_proprotein_precursor__Gallus_gallus_:0.00000001,XP_010704997_1_transforming_growth_factor_beta_2_proprotein__Meleagris_gallopavo_:0.00000001):0.00000001,(XP_006265110_1_PREDICTED__transforming_growth_factor_beta_2__Alligator_mississippiensis_:0.00000001,XP_006022407_1_transforming_growth_factor_beta_2__Alligator_sinensis_:0.00271076):0.02177572):0.00268355):0.0390915):0.07309793);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)