Click here to access PB0159 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0159 P00751 Complement factor B CFB AHUS4, ARMD14, BF, BFD, CFAB, CFBD, FB, FBI12, GBG, H2-Bf, PBF2 Homo_sapiens Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

DomainsGene Ontology
PF00084 (3_Sushi)
PF00089 (Trypsin)
PF00092 (VWA)
GO:0001848 (enables) complement binding
GO:0004252 (enables) serine-type endopeptidase activity
GO:0005515 (enables) protein binding
GO:0008233 (enables) peptidase activity
GO:0008236 (enables) serine-type peptidase activity
GO:0016787 (enables) hydrolase activity
GO:0002376 (involved in) immune system process
GO:0006508 (involved in) proteolysis
GO:0006956 (involved in) complement activation
GO:0006957 (involved in) complement activation, alternative pathway
GO:0045087 (involved in) innate immune response
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005886 (located in) plasma membrane
GO:0070062 (located in) extracellular exosome
GO:0072562 (located in) blood microparticle

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)