PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0156 | P35555 | Fibrillin-1 | FBN1 | ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | Homo_sapiens | Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921). |
Domains | Gene Ontology |
PF00683 (9_TB) PF07645 (39_EGF_CA) PF12662 (2_cEGF) PF18193 (Fibrillin_U_N) |
GO:0005178 (enables) integrin binding
GO:0005179 (enables) hormone activity GO:0005201 (enables) extracellular matrix structural constituent GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008201 (enables) heparin binding GO:0030023 (enables) extracellular matrix constituent conferring elasticity GO:0042802 (enables) identical protein binding GO:0044877 (enables) protein-containing complex binding GO:0001501 (involved in) skeletal system development GO:0001656 (involved in) metanephros development GO:0001822 (involved in) kidney development GO:0007165 (involved in) signal transduction GO:0007507 (involved in) heart development GO:0009653 (involved in) anatomical structure morphogenesis GO:0033627 (involved in) cell adhesion mediated by integrin GO:0035582 (involved in) sequestering of BMP in extracellular matrix GO:0035583 (involved in) sequestering of TGFbeta in extracellular matrix GO:0043010 (involved in) camera-type eye development GO:0045671 (involved in) negative regulation of osteoclast differentiation GO:0048048 (involved in) embryonic eye morphogenesis GO:0048050 (involved in) post-embryonic eye morphogenesis GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus GO:1990314 (involved in) cellular response to insulin-like growth factor stimulus GO:2001205 (involved in) negative regulation of osteoclast development GO:0001527 (located in) microfibril GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0005615 (located in) extracellular space GO:0005788 (located in) endoplasmic reticulum lumen GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |