PB0156
DATABASE


Click here to access PB0156 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0156 P35555 Fibrillin-1 FBN1 ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFLS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 Homo_sapiens Binds heparin and this interaction has an important role in the assembly of microfibrils (PubMed:11461921).

DomainsGene Ontology
PF00683 (9_TB)
PF07645 (39_EGF_CA)
PF12662 (2_cEGF)
PF18193 (Fibrillin_U_N)
GO:0005178 (enables) integrin binding
GO:0005179 (enables) hormone activity
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0030023 (enables) extracellular matrix constituent conferring elasticity
GO:0042802 (enables) identical protein binding
GO:0044877 (enables) protein-containing complex binding
GO:0001501 (involved in) skeletal system development
GO:0001656 (involved in) metanephros development
GO:0001822 (involved in) kidney development
GO:0007165 (involved in) signal transduction
GO:0007507 (involved in) heart development
GO:0009653 (involved in) anatomical structure morphogenesis
GO:0033627 (involved in) cell adhesion mediated by integrin
GO:0035582 (involved in) sequestering of BMP in extracellular matrix
GO:0035583 (involved in) sequestering of TGFbeta in extracellular matrix
GO:0043010 (involved in) camera-type eye development
GO:0045671 (involved in) negative regulation of osteoclast differentiation
GO:0048048 (involved in) embryonic eye morphogenesis
GO:0048050 (involved in) post-embryonic eye morphogenesis
GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus
GO:1990314 (involved in) cellular response to insulin-like growth factor stimulus
GO:2001205 (involved in) negative regulation of osteoclast development
GO:0001527 (located in) microfibril
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005615 (located in) extracellular space
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031012 (located in) extracellular matrix
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)