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PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0129 | P02458 | Collagen alpha-1(II) chain | COL2A1 | ANFH, AOM, COL11A3, SEDC, STL1, collagen type II alpha 1 chain | Homo_sapiens | Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. |
Domains | Gene Ontology |
PF00093 (VWC) PF01391 (6_Collagen) PF01410 (COLFI) |
GO:0005201 (enables) extracellular matrix structural constituent
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength GO:0042289 (enables) MHC class II protein binding GO:0042802 (enables) identical protein binding GO:0043394 (enables) proteoglycan binding GO:0046872 (enables) metal ion binding GO:0048407 (enables) platelet-derived growth factor binding GO:0001501 (involved in) skeletal system development GO:0001502 (involved in) cartilage condensation GO:0001503 (involved in) ossification GO:0001894 (involved in) tissue homeostasis GO:0001958 (involved in) endochondral ossification GO:0002062 (involved in) chondrocyte differentiation GO:0003007 (involved in) heart morphogenesis GO:0006029 (involved in) proteoglycan metabolic process GO:0007417 (involved in) central nervous system development GO:0007601 (involved in) visual perception GO:0007605 (involved in) sensory perception of sound GO:0010468 (involved in) regulation of gene expression GO:0030198 (involved in) extracellular matrix organization GO:0030199 (involved in) collagen fibril organization GO:0030903 (involved in) notochord development GO:0035108 (involved in) limb morphogenesis GO:0042472 (involved in) inner ear morphogenesis GO:0048705 (involved in) skeletal system morphogenesis GO:0048839 (involved in) inner ear development GO:0051216 (involved in) cartilage development GO:0060021 (involved in) roof of mouth development GO:0060174 (involved in) limb bud formation GO:0060272 (involved in) embryonic skeletal joint morphogenesis GO:0060348 (involved in) bone development GO:0060351 (involved in) cartilage development involved in endochondral bone morphogenesis GO:0071599 (involved in) otic vesicle development GO:0071773 (involved in) cellular response to BMP stimulus GO:0097065 (involved in) anterior head development GO:2001240 (involved in) negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0005615 (is active in) extracellular space GO:0031012 (is active in) extracellular matrix GO:0005576 (located in) extracellular region GO:0005592 (located in) collagen type XI trimer GO:0005604 (located in) basement membrane GO:0005737 (located in) cytoplasm GO:0005788 (located in) endoplasmic reticulum lumen GO:0005581 (part of) collagen trimer GO:0005585 (part of) collagen type II trimer GO:0062023 (part of) collagen-containing extracellular matrix |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |