Click here to access PB0122 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0122 P49746 Thrombospondin-3 THBS3 TSP3 Homo_sapiens Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Can bind to fibrinogen, fibronectin, laminin and type V collagen.

DomainsGene Ontology
PF02412 (6_TSP_3)
PF05735 (TSP_C)
PF07645 (2_EGF_CA)
PF11598 (COMP)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0003417 (involved in) growth plate cartilage development
GO:0007155 (involved in) cell adhesion
GO:0007160 (involved in) cell-matrix adhesion
GO:0043931 (involved in) ossification involved in bone maturation
GO:0060346 (involved in) bone trabecula formation
GO:0005576 (located in) extracellular region
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0062023 (located in) collagen-containing extracellular matrix

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)