PB0119

DATABASE

Click here to access PB0119 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0119	Q5T4F7	Secreted frizzled-related protein 5	SFRP5	SARP3	Homo_sapiens	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

Domains

Gene Ontology

PF01392 (Fz) PF01759 (NTR)

GO:0017147 (enables) Wnt-protein binding GO:0006915 (involved in) apoptotic process GO:0007163 (involved in) establishment or maintenance of cell polarity GO:0007165 (involved in) signal transduction GO:0007601 (involved in) visual perception GO:0008285 (involved in) negative regulation of cell population proliferation GO:0009653 (involved in) anatomical structure morphogenesis GO:0016055 (involved in) Wnt signaling pathway GO:0030111 (involved in) regulation of Wnt signaling pathway GO:0030154 (involved in) cell differentiation GO:0030178 (involved in) negative regulation of Wnt signaling pathway GO:0030510 (involved in) regulation of BMP signaling pathway GO:0043433 (involved in) negative regulation of DNA-binding transcription factor activity GO:0051898 (involved in) negative regulation of protein kinase B signaling GO:0060070 (involved in) canonical Wnt signaling pathway GO:0090090 (involved in) negative regulation of canonical Wnt signaling pathway GO:2000057 (involved in) negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 OS=Homo sapiens OX=9606 GN=SFRP5 PE=2 SV=3 MRAAAAGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADL PLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRP IYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKI CAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDT KRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFS YPCSLYYPFFYGAAEPH >tr|F1QJG6|F1QJG6_DANRE Secreted frizzled-related protein 5 OS=Danio rerio OX=7955 GN=sfrp5 PE=3 SV=1 MAELKRQVSLTQAVTLALVLLTSASSAEEYDYYSWQSDNFHSGRFYAKQPQCVDIPADLR LCYNVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPI YPCRSLCEAVRDSCAPVMETYGFPWPEMLQCEKFPIDNDLCIPMQFSAGHVTQTPVSKVC PPCDNELKADTIMEHYCASDFALKMKIKEAKKEKGDRKLIAAQKKKKVLKMGILRKKDLK KLTLYIKNGANCPCSQLDNLGSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYIKSQ QCPTYHSVFQ
Selected proteins from model organisms >sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 OS=Homo sapiens OX=9606 GN=SFRP5 PE=2 SV=3 MRAAAAGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADL PLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRP IYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKI CAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDT KRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFS YPCSLYYPFFYGAAEPH >tr|F1QJG6|F1QJG6_DANRE Secreted frizzled-related protein 5 OS=Danio rerio OX=7955 GN=sfrp5 PE=3 SV=1 MAELKRQVSLTQAVTLALVLLTSASSAEEYDYYSWQSDNFHSGRFYAKQPQCVDIPADLR LCYNVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPI YPCRSLCEAVRDSCAPVMETYGFPWPEMLQCEKFPIDNDLCIPMQFSAGHVTQTPVSKVC PPCDNELKADTIMEHYCASDFALKMKIKEAKKEKGDRKLIAAQKKKKVLKMGILRKKDLK KLTLYIKNGANCPCSQLDNLGSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYIKSQ QCPTYHSVFQ >NP_061250.2 secreted frizzled-related protein 5 precursor [Mus musculus] MWVAWSARTAALALLLGALHGAPTRGQEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRL PNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYG FPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKI DNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLTAVYR WDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] MRAAAGGARAAALALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESL AEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLC IAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKR LVLHMKNGAGCPCPQLDNLAGSFLVMGRRVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001083946.1 secreted frizzled-related protein 5 L homeolog precursor [Xenopus laevis] MRFQWNILAWVNSVLLGLVLWSSAEEYDYYSWQSDNFQNGRFYTKQSQCIDIPSDLHLCHNVGYKKMRLPNLLDHETMPE VKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDNDLCIT VQFGSKQVTQPPVTKICTQCEIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLV LYIKNAASCPCPQLDNLSGSFLIMGRKVDNKLILTAIYKWDKKSKDMKYAVNFMYSYPCSDTISHGTGSHLGSFR >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] MCRAAHVPHAMGSGKNSAVLPSEYDYVSYQSDLGAYQSGRFYPKPHQCVPIPADLRLCHSVGYDKMVLPNLLDHETMAEV KHQASSWVPLLNKNCHMGTQVFLCALFAPVCLDRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPQDDVCIAMT TPNATEVARPKGSGVCPPCDNEMKSEAIIEHLCASEFALKMTIKEVKRENGDRKIIPKKRKALKMGPIRKKNLKKLVLYL KNGAGCPCHQLDNLNHYFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPDCPTFPSVFK >NP_776886.1 secreted frizzled-related protein 5 precursor [Bos taurus] MRAAAGGARAAVLALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIK IENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001101061.1 secreted frizzled-related protein 5 precursor [Rattus norvegicus] MRVAGGARTAALALLLGALHGAPARGQEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRL PNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYG FPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEIEHSADGLMEQMCSSDFVVKMRIKEIKI DNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCPCPQLDNLTGSFLVMGRKVEGQLLLTAVYR WDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001305376.1 secreted frizzled-related protein 5 precursor [Gallus gallus] MPRASGPTGTVTLALLALALAPGEGQHYDYYGWQPESVPRGRLYGREPQCVDIPADMQLCHDVGYKRMRL PNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFLCSLFAPVCLDRPIYPCRSLCEVVRDACAPVMESYG FPWPEMLHCGKFPSDHDLCIAVQFGNNQATPPPVPKICTQCEMEHKADGMMQQMCSSDFVVKMRIKEVIE ENGEKRLVAAQKKKVLKLGPLKRKDTKKMVLHMRNTGSCPCPQLANLSGSFLVLGRKVGSRLLLLAIYPW QKHNKEMKFAVKFMFSYPCPLYHPLLYGAGQH >XP_016774536.1 secreted frizzled-related protein 5 [Pan troglodytes] MPREAGSPGEKRWARPGPRQGSRAGRGAQDLALGGTLGQGAGGAEGRPHCLPALELGPGGRRLAGAHGEA RAGAPRWEAPGSVGAPAAQAATHLGDLRGGGGWVESGPGAHAGTTGPPGTERRGAARRAPGEGAAMRAAA AAGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPN LLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFP WPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIEN GDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWD KKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_543955.4 secreted frizzled-related protein 5 isoform X3 [Canis lupus familiaris] MANAVGGERPGRRASPAPRQGSGCAGRGAREAAGGAEGLHLASAPGPGAGGRRLAGARGEAGAPGWEVPG SVGAPGAERRLRALGPRRRRRGGCAGAGPLETPRAMRGPAGGARAAALALLLGALHGAPAGAEEYDYYGW QAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVF LCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAMQFGHLPATAPPV TKICTQCEMEHSADGLMEQMCSSDFVVKMRIKEIKLENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHM KNGASCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001230335.1 secreted frizzled-related protein 5 precursor [Sus scrofa] MRAAARGARAAALALLLGALHGAPAHGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRLKEIK IESGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAVEPH >XP_002718655.1 PREDICTED: secreted frizzled-related protein 5 [Oryctolagus cuniculus] MRAAGGARAAALALLLGALHGAPASGEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRL PNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYG FPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKL ENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYR WDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_024109539.1 secreted frizzled-related protein 5 [Pongo abelii] MRAAAGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVAKMRIKEIM IENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_010712904.1 secreted frizzled-related protein 5 isoform X1 [Meleagris gallopavo] MLRASGPAGTVTLALLALALARGEGQHYDYYGWQPENVPRGRFYGREPQCVDIPADMQLCHDVGYKRMRL PNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFLCSLFAPVCLDRPIYPCRSLCEVVRDACAPVMESYG FPWPEMLHCGKFPSDHDLCITVQFGNNQATPPPVCTVTAKSIQPGALHLCRFPHPCRSPQAGEGMSSEGS LGSGSVPKICTQCEMEHKADGMMQQMCSSDFVVKMRIKEVIEENGERRLVAAQKKKVLKLGPLKRKDTKK MVLHMRNTGSCPCPQLDNLSGSFLVLGRKVGGRLLLLAIYPWRKHNKEMKFAVKFMFSYPCPLYHPLLYG AGQH >XP_003825732.4 secreted frizzled-related protein 5 [Pan paniscus] MPREAGSPGEKRWARPGPRQGSRAGRGAQDLALGGTLGQGAGGAEGRPHCLPALELGPGGRRLAGAHGEA RAGAPRWEAPGSVGAPAAQAATHLGDLRGGGGWVESGPGAHAGTTGPPGTERRGAARRAPGEGAAMRAAA AAGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMRLPN LLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFP WPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIEN GDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVYRWD KKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_023096575.1 secreted frizzled-related protein 5 [Felis catus] MRAAAGGARAAALALLLGALHGAPARGEENDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIK IENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGASCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_027816131.1 secreted frizzled-related protein 5 [Ovis aries] MRAAAGGARAAALALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIK IENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_004049962.2 secreted frizzled-related protein 5 [Gorilla gorilla gorilla] MQAAAAAGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHGRSYSKPPQCLDIPADLPLCHTVGYKR MRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLME AYGFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKE IKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMA VYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_004077190.1 secreted frizzled-related protein 5 [Oryzias latipes] MAHGQKSPRWALTQSSFGLALGLLLFSLLLLTIVAADEYDYYSWQSDNFHNGRFYTKQPQCVDIPSDLRL CHNVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVR NSCAPVMETYGFPWPDMLTCDKFPIDNDLCIPMQFAGNHATLPPVPKVCPPCDNELKTDNIMEHYCASDF VLKMKIKEVKKEKADRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCPCSQLDSLGSHFLVMGRKV DQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHSVFQ >XP_005507091.1 secreted frizzled-related protein 5 [Columba livia] MGLAANKGSVCRLAGATQGQKMLGGRQGGVGPAAGPGALPDTFLWLLGKREHCLDIPPDMQLCRDVGYKR MRLPNLLEHESMAEAKQQASSWVPLLAKQCHTDTQLFLCSLFAPVCLDRPVYPCRSLCEVVRDSCAPVME SYGFPWPEMLHCGKFPPDHELCIAVQFGNSKATPPPVSKICTQCEMEHKADGMMEQMCSSDFVVKMRIKE ITEENGERRLVAAQKKKVLKLGPLKRKDTKKMVLHMRNAGACPCPQLDSLSGSFLVMGRKVGGRLLLLAV YPWQKHNKEMKFAVKFMFSYPCPLYHPGAGQH >XP_005698444.3 PREDICTED: secreted frizzled-related protein 5 [Capra hircus] MRAAAGGARAAALALLLGALHGAPARAEEYDYYGWQTEPLHGRSHSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIK IENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_006033802.2 secreted frizzled-related protein 5 [Alligator sinensis] MSQRARGGKAGLEGCWEAVGLSWGSPAVQPGLGPWEQREAQDKELGRVPGWAGQAGGGGGRCEGPEQAAP GSCDSTPRCASPAPRFPPSGRTDAQALGPAMGGGPGLLALALVVSGAVGAGPSYEAYGRFSAKAPQCVDI PGDLQLCHDVGYKRMRLPNLLEHDSLAEVKQQAGSWVPLLAKRCHSDTQLFLCALFAPVCLERPVYPCRS LCEVVRDACGPVMESYGFPWPDMLHCAQFPPDHGLCIAVQFGHGQVTAPPVPRLCPQCEVEHKADGMMEQ MCSSDFVVKLRIKEVVQEGAERRLVAAPKKKVLKLGPLQRKDERRMVLHMRNAGACPCPQLDHLGGSFLV LGRKAGGRLLLLAIYRWQKRDPEVKFAVKFMFSYPCPLYHPLLLHSAQHR >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] MALGQKSPRLALTQGFFSLALGLLLFSLLLFTIVDADEYDYYNWQADNFHNGRFYTKQPQCVDIPADLRL CHNVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVR DSCAPVMETYGFPWPEMLNCDKFPIDNDLCIPMQFAANHVTQPPVSNVCPPCDNEMKADNIMEHYCASDF ALKMKIKEVKKEKGDRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCPCSQLENLGSNFLIMGRKV DQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHSVFQ >XP_020739154.1 secreted frizzled-related protein 5 [Odocoileus virginianus texanus] MRAAAGGARAAALALLLGALHGAPARGEEYDYYGWQTEPLHGRSYSKPPQCLDIPADLPLCHTVGYKRMR LPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAY GFPWPEMLHCHKFPLDNDLCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIK IENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRRVDGQLLLMAVY RWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_030297987.1 secreted frizzled-related protein 5 [Sparus aurata] MAHGQKSPRWALTQGSFSLALGLSLFSLLLLLFTVSAADEYDYYSWQSDNFHNGRFYTKQPQCVDIPADL RLCHNVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEA VRDSCAPVMETYGFPWPEMLTCDKFPIDNDLCIPMQFTGNHATQPPVSKVCPPCDNELKADNIMEHYCAS DFALKMKIKEVKKEKGDRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCPCSQLDSLGSSFLIMGR KVDQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHTVFQ >XP_040217204.1 secreted frizzled-related protein 5 [Rana temporaria] MQFQWNIVACVNSLLVGLVLWSSAEEYDYYSWQSDNFQNGRFYTKQSQCVDIPQDLGLCHNVGYKKMRLP NLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGF PWPEMLNCNKFPIDNDLCIAVQFGSKQVTQPPVTKICTQCEIEQKSETMRVQYCASDFVVRMRIKEVKIE NGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAAGCPCPQLENPSGSFLIMGRKVDNKLLLTAIYKW DKKSKDMKYAVNFMFTYPCSETISHSAGSHLGSFR >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] MIERVLVVLLAFAASSPGVWGQETETDMAMLGVNSRTYPLDLSGRPKETDCVDIPEDLSLCQNIGYTRMRMPNLLEHDSL DEVRNQAKSWVPLLLQRCHEGTQLFLCTLFAPVCLEVDRPIYPCRSLCEEVQAGCGPLMESNCFPWPAMLQCDKFPEDND LCIRLNMRNQNGTVEAQPFEMSAAMQEAYMMHFTQCHDDSLEDTLLRKFCNSDFVLKVKIKTIRESKDGKKYIGDPNPEK LEVLKQGSLKTKDLQRLTFYVREGANCQCDMLERSGNYLLVMGHRDSKKNRKLFMTFVHSWEKTRDFRRAIKGFENPDMC ENLETATEGRREEIAPQDAEPHEMTPADEVLLASQTNTPVNDGVYTTHQVMADETPSPKTNTRRERKRGKRTRDRPRKNR ERENREMPVRRARSKWD >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] MTIGSIVIVLLNALLCSANTFGAFTGVDTASPFAKNFVCEPIPHSLKLCRNIAYNQMRLPNLLGHETMDEVKQQAASWVP LLNKRCHKDLQRLLCSLFSPVCIEDSPEPIYPCQSLCQAVKGACEPVMQKVGYPWPDMLSCDKFRDNDMCVPQECHHNCS SYAEPESTPICPACGNELDAETILNLYCAVEFVLKVKIRSVKTSRKDLKLMADKRKRVIYQEGSLKRKDLRKLTLLIRGG KSCTCPHLEPQGKGKKKKKDFYLVMGGKVGRKLLVSAIYRWPKKLKMLRRLSKKFTPDLCS >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] MIGSVVVVMAACLAQMTAGFAMDLSGRITKPTCVDIPVDLALCQNIGYNRMRMPNLLDHDSIFEVKDQSQGWIPLLMVNC DNDTQLFLCSLFSPVCLDRPIYPCRSLCRKVRQNCEPIMLRNCFPWPSMLECDRFPEDNGLCIQSEMRQRNATDQPTQSS GSMIPSGIGMSGMVAAVGSLFTQCHDDADAASIVEYFCNADFVLKMKLKEVKETDEGMRYVGDPTPGKFAVIKQGSLKQK DLAKMRFWTREGANCGCDMLRPRKENFLVMGHRDGKKLYMTYVHIWTKSRELRNANKQFAQPCPGDGVESSELPATKKPR KDRGGKKGRPDRRERPGRDGAAETTTQAVTERKLTREERRQLREQMRETKRENRRNKE >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] MMLFPVLYILFAFSVTNGYLEDSWAMFSSERPVGPKCVDIPSNLSICNGIEYTQMRLPNILEHETVSEAIHASKDWESLL RLNCHPDTQRFLCSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFEDDDMCIKPMQPAKPPAG SSTTCTACSQVATYENLVDQFCRSHLVLKAKVIRDSPTHIRVRNGRSLKKGERRRGVSDVEIRLSSESDGSCPCNIPVKN QNEKLLVMASRQPDGKYLANLVLPWQKEKNFKRAIHQFQRLNCQSLGREIRESASRRPHYYEMRRHNTGRYQMF >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] MDFLRCLLLLAGVFHVALCYRTRSHHCVDITSNTAPLCANLSLGYDKMMLPNFLRHDTAMEVRRELAQWSPLVGSGCHPY LKHFLCSVFAPVCMLELIPPCRSLCSMVQNSCEPLMRRHNYTWPSMLDCRKYPENSMCVKIETPTPIPTTTVCEEDGSNV PLDELQKKFCDSDFAMRARVSEKKMKDGYLILKATAIKSLKGSLKRDQLQRLRIPNMESRNCGYVNKRKQFLILGTKRGR RMIVTYLMKWKDFRNMRRKIKEKACRKM >XP_006568530.1 frizzled-2 [Apis mellifera] MIPRYAIYVFSVAVFSVNALHTKDPLAHHGRCEPITINLCMNIPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPD LRFFLCTVYAPVCTIIDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPENGGPELCVGHNETTPPEPSPPVYT PPRMPVAEFQPSWTGGPKTYGSGFMLGARDFGFVCPMQFKVPHELGYSLKVGDKVELNCGAPCDGMFFTERERRFSRIWV GTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFLSVCYLMVALAYVIGWAAGNSIACREPFPPPLDMRIQMASTITQGT KHELCTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLAAWAAPAIKTVTILAMGKVEGDILSGVC YVGLWNVEALRGFVLAPLCVYLILGTAFLLAGFVSLFRIRTVMKHDGTKTDKLEKLMIRIGIFSVLYIVPALIVIACLFY EQAYFDQWMLTWNMEMCSRPGPQSLYSMPCPVGERTRDVGRRPEFEVFMIKYLMAMIVGITSSFWVWSSKTLTSWRQFFN HIQGRRAEAYV >CAA38459.1 frizzled [Drosophila melanogaster] MWRQILFILPTLIQGVQRYDQSPLDASPYYRSGGGLMASSGTELDGLPHHNRCEPITISICKNIPYNMTIMPNLIGHTKQ EEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTILERPIPPCRSLCESARVCEKLMKTYNFNWPENLECSKFPVHGGE DLCVAENTTSSASTAATPTRSVAKVTTRKHQTGVERPHRNIGFVCPVQLKTPLGMGYELKVGGKDLHDCGAPCHAMFFPE RERTVLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFLAVCYLVVGCAYVAGLGAGDSVSCREPFPPPVKLGR LQMMSTITQGHRQTTSCTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLVAWAVPALQTISVLAL AKVEGMYLWQFHTIN >CAE1258256.1 FZD4 [Sepia pharaonis] MNPNYDTMAYLTFTLSAKYLFSFCMTFSFSPISSINSCLLKDGLFIFWFGQSGRPAVTLAEVVRTCDPIEIPTCKGQGYN VTGMPNLAGNDMQRDAQLQLNTFNPLIQYGCSSQLTFFLCSVFVPMCTDKVKDPIGPCRPMCESVKRKCQPVLQEFGFSW PDILNCTKFPPRNNQDHMCMDGPGENEDEETHHTVGQTPQGSRSGVGRTGKNRNANVGGWQHGKPPFPNMHRVGTCLHMR HPENYVYVNRTERCALRCGRHDAFSYNDKEFSDVWMAIWSILCFSSTLFTVLTFLIDSQRIRYPEQPIIFLAMCYNIYSI AYIVRLVAGRQNISCDVHREMRREYSILIQEGLENTDCAIVFLLLYFFGTASALWWVILTLTWFFSAGLKWSHEALQVHS SYFHLTAWAIPAIKTIIILIMRDVDADELTGICFVGNQNDKSLIGTLTEKTGTQLAPRRSQA
Mafft alignment of selected proteins >sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 OS=Homo sapiens OX=9606 GN=SFRP5 PE=2 SV=3 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MRA-----AAAGGGVRTAALA-------LL ------------------LGALHWAPARCEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >tr|F1QJG6|F1QJG6_DANRE Secreted frizzled-related protein 5 OS=Danio rerio OX=7955 GN=sfrp5 PE=3 SV=1 M----------------------------------------------------------- -------------------AE--------------------------------------- ------------------------------LK-------RQVSLTQAVTLA-------LV ---------------------LLTSASSAEEYDYYS--WQSD--NFHSGRFY----AKQP QCVDIPADLR-LCYN--VGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLQCEKFPIDN---DLC IPMQFSA-----GHVT--QTP--------------------------------------- ---VSKVCPPC--DNELKADTIMEHYCASDFALKMKIKEAKKEKGDRKLIAAQK--KKKV LKMGI------LRKKDLK-KLTLYI----------------------------------- ------------------KNGANC----PCS-QL-DNLG-------SNFLIMG---RKVD QQLLLMSIH-----------------------KWDKKSKELKFAIKYIK-SQQCP----- -----------------------------------TYHSVFQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_061250.2 secreted frizzled-related protein 5 precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MW--------VAWSARTAALA-------LL ------------------LGALHGAPTRGQEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQK--KKKL LKAGP------LKRKDTK-KLVLHM----------------------------------- ------------------KNGASC----PCP-QL-DNLT-------GSFLVMG---RKVE GQLLLTAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAALA-------LL ------------------LGALHGAPARGEEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DNLA-------GSFLVMG---RRVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_001083946.1 secreted frizzled-related protein 5 L homeolog precursor [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------FQWNILAWVNSV-------LL ---------------------GLVLWSSAEEYDYYS--WQSD--NFQNGRFY----TKQS QCIDIPSDLH-LCHN--VGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFL CSLFAPICL---ERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDN---DLC ITVQFGS-----KQVT--QPP--------------------------------------- ---VTKICTQC--EIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQK--KKKV LKAGK------LKRKEFR-KLVLYI----------------------------------- ------------------KNAASC----PCP-QL-DNLS-------GSFLIMG---RKVD NKLILTAIY-----------------------KWDKKSKDMKYAVNFMY-SYPCS----- -------------------------------------DTISHGTGS-HLGSFR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MC-------------RAAHVP-------HA ------------------MGSGKNSAVLPSEYDYVS--YQSDLGAYQSGRFY----PKPH QCVPIPADLR-LCHS--VGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFL CALFAPVCL---DRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPQD----DVC IAMTTPN----ATEVA--RPK--------------------------------------- ---GSGVCPPC--DNEMKSEAIIEHLCASEFALKMTIKEVKRENGDRKIIPK----KRKA LKMGP------IRKKNLK-KLVLYL----------------------------------- ------------------KNGAGC----PCH-QL-DNLN-------HYFLIMG---RQVK SQYLLTAIY-----------------------KWDKKNKEFKQFMKKMK-SPDCP----- -----------------------------------TFPSVFK------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_776886.1 secreted frizzled-related protein 5 precursor [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAVLA-------LL ------------------LGALHGAPARGEEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKSGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNSAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_001101061.1 secreted frizzled-related protein 5 precursor [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR--------VAGGARTAALA-------LL ------------------LGALHGAPARGQEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EIEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQK--KKKL LKAGP------LKRKDTK-KLVLHM----------------------------------- ------------------KNGASC----PCP-QL-DNLT-------GSFLVMG---RKVE GQLLLTAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_001305376.1 secreted frizzled-related protein 5 precursor [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MP-------RASGPTGTVTLA-------LL --------------------ALALAPGEGQHYDYYG--WQPE--SVPRGRLY----GREP QCVDIPADMQ-LCHD--VGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFL CSLFAPVCL---DRPIYPCRSLCEVVRDACAPVMESYGFPWPEMLHCGKFPSDH---DLC IAVQFGN-----NQAT--PPP--------------------------------------- ---VPKICTQC--EMEHKADGMMQQMCSSDFVVKMRIKEVIEENGEKRLVAAQ---KKKV LKLGP------LKRKDTK-KMVLHM----------------------------------- ------------------RNTGSC----PCP-QL-ANLS-------GSFLVLG---RKVG SRLLLLAIY-----------------------PWQKHNKEMKFAVKFMF-SYPCP----- -----------------------------------LYHPLLYGAGQ-H------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_016774536.1 secreted frizzled-related protein 5 [Pan troglodytes] MPREAGSPGEKRWARPGPRQGSR-AG-RGAQDLALGGTLGQGAGGAEGRPHCLPALELGP GGRRLAGAHGEARAGAPRWEAPGSVGAPAAQAATHLGDLRGGGGWVESGPGAHAGTTGPP GTERRGAARRAPGEGA-------------AMRA-----AAAAGGVRTAALA-------LL ------------------LGALHWAPARCEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_543955.4 secreted frizzled-related protein 5 isoform X3 [Canis lupus familiaris] MANAVGGERPGRRASPAPRQGSGCAG-RGAR---------EAAGGAEGL-HLASAPGPGA GGRRLAGARGE--AGAPGWEVPGSVGAPGAERR-----LR---------------ALGPR RRRRGGCAGAGPLETP------------RAMR-------GPAGGARAAALA-------LL ------------------LGALHGAPAGAEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAMQFGH-----LPAT--APP--------------------------------------- ---VTKICTQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKLENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGASC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >NP_001230335.1 secreted frizzled-related protein 5 precursor [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAARGARAAALA-------LL ------------------LGALHGAPAHGEEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRLKEIKIESGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAVEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_002718655.1 PREDICTED: secreted frizzled-related protein 5 [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR--------AAGGARAAALA-------LL ------------------LGALHGAPASGEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKLENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_024109539.1 secreted frizzled-related protein 5 [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGVRTAALA-------LL ------------------LGALHWAPARCEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVAKMRIKEIMIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_010712904.1 secreted frizzled-related protein 5 isoform X1 [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------ML-------RASGPAGTVTLA-------LL --------------------ALALARGEGQHYDYYG--WQPE--NVPRGRFY----GREP QCVDIPADMQ-LCHD--VGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFL CSLFAPVCL---DRPIYPCRSLCEVVRDACAPVMESYGFPWPEMLHCGKFPSDH---DLC ITVQFGN-----NQAT--PPPVCTVTAKSIQPGALHLCRFPHPCRSPQAGEGMSSEGSLG SGSVPKICTQC--EMEHKADGMMQQMCSSDFVVKMRIKEVIEENGERRLVAAQ---KKKV LKLGP------LKRKDTK-KMVLHM----------------------------------- ------------------RNTGSC----PCP-QL-DNLS-------GSFLVLG---RKVG GRLLLLAIY-----------------------PWRKHNKEMKFAVKFMF-SYPCP----- -----------------------------------LYHPLLYGAGQ-H------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_003825732.4 secreted frizzled-related protein 5 [Pan paniscus] MPREAGSPGEKRWARPGPRQGSR-AG-RGAQDLALGGTLGQGAGGAEGRPHCLPALELGP GGRRLAGAHGEARAGAPRWEAPGSVGAPAAQAATHLGDLRGGGGWVESGPGAHAGTTGPP GTERRGAARRAPGEGA-------------AMRA-----AAAAGGVRTAALA-------LL ------------------LGALHWAPARCEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_023096575.1 secreted frizzled-related protein 5 [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAALA-------LL ------------------LGALHGAPARGEENDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGASC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_027816131.1 secreted frizzled-related protein 5 [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAALA-------LL ------------------LGALHGAPARGEEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_004049962.2 secreted frizzled-related protein 5 [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MQA-----AAAAGGVRTAALA-------LL ------------------LGALHWAPARCEEYDYYG--WQAE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_004077190.1 secreted frizzled-related protein 5 [Oryzias latipes] MAH--------------------------------------------G------------ -------------QKSPRWAL--------------------------------------- ------------------------------TQ-------SSFGLALGLLLF-------SL ---------------------LLLTIVAADEYDYYS--WQSD--NFHNGRFY----TKQP QCVDIPSDLR-LCHN--VGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRNSCAPVMETYGFPWPDMLTCDKFPIDN---DLC IPMQFAG-----NHAT--LPP--------------------------------------- ---VPKVCPPC--DNELKTDNIMEHYCASDFVLKMKIKEVKKEKADRKLIAAQK--KKKV LKQGV------LRKKDLK-KLTLYI----------------------------------- ------------------KNGANC----PCS-QL-DSLG-------SHFLVMG---RKVD QQLLLMSIH-----------------------KWDKKSKELKFAIKYMK-SHQCP----- -----------------------------------TYHSVFQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_005507091.1 secreted frizzled-related protein 5 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MG-------LAANKGSVCRLAGATQGQKML ---------------GGRQGGVGPAAGPGALPDTFL--W-----------LL----GKRE HCLDIPPDMQ-LCRD--VGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHTDTQLFL CSLFAPVCL---DRPVYPCRSLCEVVRDSCAPVMESYGFPWPEMLHCGKFPPDH---ELC IAVQFGN-----SKAT--PPP--------------------------------------- ---VSKICTQC--EMEHKADGMMEQMCSSDFVVKMRIKEITEENGERRLVAAQ---KKKV LKLGP------LKRKDTK-KMVLHM----------------------------------- ------------------RNAGAC----PCP-QL-DSLS-------GSFLVMG---RKVG GRLLLLAVY-----------------------PWQKHNKEMKFAVKFMF-SYPCP----- -----------------------------------LYHP---GAGQ-H------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_005698444.3 PREDICTED: secreted frizzled-related protein 5 [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAALA-------LL ------------------LGALHGAPARAEEYDYYG--WQTE--PL-HGRSH----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RKVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_006033802.2 secreted frizzled-related protein 5 [Alligator sinensis] MSQ---------------RARGGKAGLEGCW---------EAVGLSWG--SPAVQPGLGP WEQREAQDKEL--GRVPGWAGQAGGGG-----------GR---------------CEGPE QAAPGSCDSTPRCASPAPRFPPSGRTDAQALGP------AMGGGPGLLALA-------LV ---------------------VSGAVGAGPSYEAY-------------GRFS----AKAP QCVDIPGDLQ-LCHD--VGYKRMRLPNLLEHDSLAEVKQQAGSWVPLLAKRCHSDTQLFL CALFAPVCL---ERPVYPCRSLCEVVRDACGPVMESYGFPWPDMLHCAQFPPDH---GLC IAVQFGH-----GQVT--APP--------------------------------------- ---VPRLCPQC--EVEHKADGMMEQMCSSDFVVKLRIKEVVQEGAERRLVAAP---KKKV LKLGP------LQRKDER-RMVLHM----------------------------------- ------------------RNAGAC----PCP-QL-DHLG-------GSFLVLG---RKAG GRLLLLAIY-----------------------RWQKRDPEVKFAVKFMF-SYPCP----- -----------------------------------LYHPLLLHSAQ-HR----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] MAL--------------------------------------------G------------ -------------QKSPRLAL--------------------------------------- ------------------------------TQ-------GFFSLALGLLLF-------SL ---------------------LLFTIVDADEYDYYN--WQAD--NFHNGRFY----TKQP QCVDIPADLR-LCHN--VGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHADTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLNCDKFPIDN---DLC IPMQFAA-----NHVT--QPP--------------------------------------- ---VSNVCPPC--DNEMKADNIMEHYCASDFALKMKIKEVKKEKGDRKLIAAQK--KKKV LKQGV------LRKKDLK-KLTLYI----------------------------------- ------------------KNGANC----PCS-QL-ENLG-------SNFLIMG---RKVD QQLLLMSIH-----------------------KWDKKSKELKFAIKYMK-SHQCP----- -----------------------------------TYHSVFQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_020739154.1 secreted frizzled-related protein 5 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MR-------AAAGGARAAALA-------LL ------------------LGALHGAPARGEEYDYYG--WQTE--PL-HGRSY----SKPP QCLDIPADLP-LCHT--VGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN---DLC IAVQFGH-----LPAT--APP--------------------------------------- ---VTKICAQC--EMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQK--KKKL LKPGP------LKRKDTK-RLVLHM----------------------------------- ------------------KNGAGC----PCP-QL-DSLA-------GSFLVMG---RRVD GQLLLMAVY-----------------------RWDKKNKEMKFAVKFMF-SYPCS----- -----------------------------------LYYPFFYGAAEPH------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_030297987.1 secreted frizzled-related protein 5 [Sparus aurata] MAH--------------------------------------------G------------ -------------QKSPRWAL--------------------------------------- ------------------------------TQ-------GSFSLALGLSLF-----SLLL ---------------------LLFTVSAADEYDYYS--WQSD--NFHNGRFY----TKQP QCVDIPADLR-LCHN--VGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFL CSLFAPVCL---DRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLTCDKFPIDN---DLC IPMQFTG-----NHAT--QPP--------------------------------------- ---VSKVCPPC--DNELKADNIMEHYCASDFALKMKIKEVKKEKGDRKLIAAQK--KKKV LKQGV------LRKKDLK-KLTLYI----------------------------------- ------------------KNGANC----PCS-QL-DSLG-------SSFLIMG---RKVD QQLLLMSIH-----------------------KWDKKSKELKFAIKYMK-SHQCP----- -----------------------------------TYHTVFQ------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_040217204.1 secreted frizzled-related protein 5 [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MQ-------FQWNIVACVNSL-------LV ---------------------GLVLWSSAEEYDYYS--WQSD--NFQNGRFY----TKQS QCVDIPQDLG-LCHN--VGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFL CSLFAPICL---ERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPIDN---DLC IAVQFGS-----KQVT--QPP--------------------------------------- ---VTKICTQC--EIEQKSETMRVQYCASDFVVRMRIKEVKIENGDRKLIAAQK--KKKV LKAGK------LKRKEFR-KLVLYI----------------------------------- ------------------KNAAGC----PCP-QL-ENPS-------GSFLIMG---RKVD NKLLLTAIY-----------------------KWDKKSKDMKYAVNFMF-TYPCS----- -------------------------------------ETISHSAGS-HLGSFR------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MIERVL-------VV LLAFAASSPGVWGQETETDMAMLGVNSRTYPLDL-------------SGR------PKET DCVDIPEDLS-LCQN--IGYTRMRMPNLLEHDSLDEVRNQAKSWVPLLLQRCHEGTQLFL CTLFAPVCL-EVDRPIYPCRSLCEEVQAGCGPLMESNCFPWPAMLQCDKFPEDN---DLC IRLNMRN-----QNGTVEAQP--FEMS--------------------------AA----M QEAYMMHFTQC--HDDSLEDTLLRKFCNSDFVLKVKIKTIRESKDGKKYIGDPNPEKLEV LKQGS------LKTKDLQ-RLTFYV----------------------------------- ------------------REGANC----QCD-ML-ERSG-------NYLLVMGHRDSKKN RKLFMTFVH-----------------------SWEK-TRDFRRAIKGFENPDMCE--NLE TAT----EGRREEIAPQDAEPHEMTPADEVLLASQTNTPVNDGVYTTHQVMADETPSP-- -----------------------------KTNTRRERKR--------------------- ---------------------------------GKRTRDRPRKNRERENR---------- -------------------------EMPVRRARSKWD >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MTIGSIV-------IV --------------------LLNALLCSANTFGAFT--------GVDTASPF----AKNF VCEPIPHSLK-LCRN--IAYNQMRLPNLLGHETMDEVKQQAASWVPLLNKRCHKDLQRLL CSLFSPVCIEDSPEPIYPCQSLCQAVKGACEPVMQKVGYPWPDMLSCDKFR-DN---DMC VPQECHH---NCSSYA--EPE--------------------------------------- ---STPICPAC--GNELDAETILNLYCAVEFVLKVKIRSVKTSRKDLKLMADKR--KRVI YQEGS------LKRKDLR-KLTLLI----------------------------------- ------------------RGGKSC----TCP-HL-EPQGKGKKKKKDFYLVMG---GKVG RKLLVSAIY-----------------------RWPKKLKMLRRLSKKFT-PDLCS----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------MIGSVV-------VV ------------------MAACLAQMTAGFAMDL-------------SGR------ITKP TCVDIPVDLA-LCQN--IGYNRMRMPNLLDHDSIFEVKDQSQGWIPLLMVNCDNDTQLFL CSLFSPVCL---DRPIYPCRSLCRKVRQNCEPIMLRNCFPWPSMLECDRFPEDN---GLC IQSEMRQ-----RNAT--DQP--TQSSGSMIP----------------SGIGMSG----M VAAVGSLFTQC--HDDADAASIVEYFCNADFVLKMKLKEVKETDEGMRYVGDPTPGKFAV IKQGS------LKQKDLA-KMRFWT----------------------------------- ------------------REGANC----GCD-ML-RPRK-------ENFLVMG---HRDG KKLYMTYVH-----------------------IWTK-SRELRNANKQF--AQPCPGDGVE SSELPATKKPRKDRGGKKGRP------------DRRERPGRDGAAETTTQAVTERKL--- --------------------------------TREER----------------------- ----------------------------------RQLREQMRET-KREN----------- -----------------------------RRNKE--- >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------MMLFPVL-------YI --------------------LFAFSVTNGYLEDSWA--------MFSSER------PVGP KCVDIPSNLS-ICNG--IEYTQMRLPNILEHETVSEAIHASKDWESLLRLNCHPDTQRFL CSLFAPVCLMQMDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFE-DD---DMC IKPMQPA-----------KPP--------------------------------------- -AGSSTTCTAC--SQVATYENLVDQFCRSHLVLKAKV--IRDSPTHIRVR------NGRS LKKGE------RRRGVSDVEIRLSS----------------------------------- ------------------ESDGSC----PCNIPV-KNQN-------EKLLVMAS--RQPD GKYLANLVL-----------------------PWQK-EKNFKRAIHQFQ-RLNCQSLGRE IRE------------------------------SASRRPHYYEMRR-HNTG--------- ------------------------------------------------------------ -------------------------------------RYQMF------------------ ------------------------------------- >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MD--------------------------FL --------------------RCLLLLAGVFHVAL-------------CYR------TRSH HCVDITSNTAPLCANLSLGYDKMMLPNFLRHDTAMEVRRELAQWSPLVGSGCHPYLKHFL CSVFAPVCM---LELIPPCRSLCSMVQNSCEPLMRRHNYTWPSMLDCRKYP-EN---SMC VKIETPT-----------PIP--------------------------------------- ---TTTVCEED--GSNVPLDELQKKFCDSDFAMRARVSEKKMKDGYLILKAT----AIKS LK-GS------LKRDQLQ-RLRIPN----------------------------------- ------------------MESRNC--------GY-VNKR-------KQFLILG---TKRG RRMIVTYLM-----------------------KWKD-FRNMRRKIKE----KACR----- ----------------------------------KM------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >XP_006568530.1 frizzled-2 [Apis mellifera] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MIP-------RY--------------AIYV ------------------FSVAVFSVNALHTKDPL----------AHHGR---------- -CE--PITIN-LCMN--IPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPDLRFFL CTVYAPVCT-IIDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPENGG-PELC VGHNETT-PPEPSPPVY-TPP--------------------------------------- RMPVAEFQPSWTGGPKTYGSGFMLGARDFGFVCPMQFKVPHELGYSLKVG------DKVE LNCGAPCDGMFFTERERR-FSRIWVGTWASVCAASCFFTFLTFLIDTDRFRYPERPIIFL SVCYLMVALAYVIGW-AAGNSIACREPFPPPLDM-RIQM-------ASTITQGT--KHEL CTVLFMVLYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEANSQYFHLA-AWAAP--AIK TVT--------------------------ILAMGKVEGDILSGVCYVGLWNVEALRGFVL APLCVYLILGTAFLLAGFVSLFRIRTVMKHDGTKTDKLEKLMIRIGIFSVLYIVPALIVI ACLFYEQAYFDQWMLTWNMEMCSRPGPQSLYSMPCPVGERTRDVGRRPEFEVFMIKYLMA MIVGITSSFWVWSSKTLTSWRQFFNHIQGRRAEA-YV >CAA38459.1 frizzled [Drosophila melanogaster] M----------------------------------------------------------- ------------------WRQI-------------------------------------- ----------------------------LFILPTLIQGVQRYDQSPLDASP-------YY ------------------RSGGGLMASSGTELDGL----------PHHNR---------- -CE--PITIS-ICKN--IPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFL CSLYVPVCT-ILERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGG-EDLC VAENTTS-----SASTA-ATP--------------------------------------- TRSVAKVTTR------KHQTGVERPHRNIGFVCPVQLKTPLGMGYELKVG------GKDL HDCGAPCHAMFFPERERT-VLRYWVGSWAAVCVASCLFTVLTFLIDSSRFRYPERAIVFL AVCYLVVGCAYVAGL-GAGDSVSCREPFPPPVKLGRLQM-------MSTITQGHR-QTTS CTVLFMALYFCCMAAFAWWSCLAFAWFLAAGLKWGHEAIENKSHLFHLV-AWAVP--ALQ TIS--------------------------VLALAKVEGMYLWQFHTIN------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------- >CAE1258256.1 FZD4 [Sepia pharaonis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------MNP-------NYDTMAYLTFTL---SAKYL F-SFCMT----------FSFSPISSINSCLLKDGLFIFW-----FGQSGRPAVTLAEVVR TCD--PIEIP-TCKG--QGYNVTGMPNLAGNDMQRDAQLQLNTFNPLIQYGCSSQLTFFL CSVFVPMCTDKVKDPIGPCRPMCESVKRKCQPVLQEFGFSWPDILNCTKFPPRNNQDHMC MDGPGENEDEETHHTVG-QTP--------------------------------------- QGSRSGVGRT---GKNRNANVGGWQHGKPPFPNMHRVGTCLHMRHPENYVYVNR-TERCA LRCGR---HDAFSYNDKE-FSDVWMAIWSILCFSSTLFTVLTFLIDSQRIRYPEQPIIFL AMCYNIYSIAYIVRLVAGRQNISC----DVHREM-RREY-------SILIQEGL--ENTD CAIVFLLLYFFGTASALWWVILTLTWFFSAGLKWSHEALQVHSSYFHLT-AWAIP--AIK TII--------------------------ILIMRDVDADELTGICFVGNQNDKSLIG--- ------------------------------------------------------------ -----------------------------------TLTEKTGTQ---------------- --------------------------LAPRRSQA---
BMGE Cleaned alignment of selected proteins >sp|Q5T4F7|SFRP5_HUMAN Secreted frizzled-related protein 5 OS=Homo sapiens OX=9606 GN=SFRP5 PE=2 SV=3 AAGGGVLGALHWAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >tr|F1QJG6|F1QJG6_DANRE Secreted frizzled-related protein 5 OS=Danio rerio OX=7955 GN=sfrp5 PE=3 SV=1 RQVSLT---LLTSAEEYDYYSSGRFYAKQPQCVDIPADLRVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLQCEKFPIDNDLCIPMQFSAVSKVCPPCDNELKADTIMEHYCASDFALKMKIKEAKKEKGDRKLIAAQKKKKVLKMGILRKKDLKKLTLYIKNGANCSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYIKSQQCPTYHSVFQ------ >NP_061250.2 secreted frizzled-related protein 5 precursor [Mus musculus] -VAWSALGALHGAPQEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCGSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >KAB0383808.1 hypothetical protein FD755_005725 [Muntiacus reevesi] AAAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRRVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001083946.1 secreted frizzled-related protein 5 L homeolog precursor [Xenopus laevis] FQWNIL---GLVLWEEYDYYSNGRFYTKQSQCIDIPSDLHVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPLDNDLCITVQFGSVTKICTQCEIEQKSETMRVQLCASDFVLRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAASCGSFLIMGRKVDNKLILTAIYKWDKKSKDMKYAVNFMYSYPCS--DTISHGTGS-H >KYO28472.1 secreted frizzled-related protein 1 [Alligator mississippiensis] ------MGSGKNSASEYDYVSSGRFYPKPHQCVPIPADLRVGYDKMVLPNLLDHETMAEVKHQASSWVPLLNKNCHMGTQVFLCALFAPVCLDRPVYPCRWLCEAVRDACEPVMQFFGFYWPDMLKCDQFPQD-DVCIAMTTPNGSGVCPPCDNEMKSEAIIEHLCASEFALKMTIKEVKRENGDRKIIPK--KRKALKMGPIRKKNLKKLVLYLKNGAGCHYFLIMGRQVKSQYLLTAIYKWDKKNKEFKQFMKKMKSPDCPTFPSVFK------ >NP_776886.1 secreted frizzled-related protein 5 precursor [Bos taurus] AAAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKSGPLKRKDTKRLVLHMKNSAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001101061.1 secreted frizzled-related protein 5 precursor [Rattus norvegicus] -VAGGALGALHGAPQEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEIEHSADGLMEQMCSSDFVVKMRIKEIKIDNGDRKLIGAQKKKKLLKAGPLKRKDTKKLVLHMKNGASCGSFLVMGRKVEGQLLLTAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001305376.1 secreted frizzled-related protein 5 precursor [Gallus gallus] RASGPT--ALALAPQHYDYYGRGRLYGREPQCVDIPADMQVGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFLCSLFAPVCLDRPIYPCRSLCEVVRDACAPVMESYGFPWPEMLHCGKFPSDHDLCIAVQFGNVPKICTQCEMEHKADGMMQQMCSSDFVVKMRIKEVIEENGEKRLVAAQ-KKKVLKLGPLKRKDTKKMVLHMRNTGSCGSFLVLGRKVGSRLLLLAIYPWQKHNKEMKFAVKFMFSYPCPLYHPLLYGAGQ-H >XP_016774536.1 secreted frizzled-related protein 5 [Pan troglodytes] AAAGGVLGALHWAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_543955.4 secreted frizzled-related protein 5 isoform X3 [Canis lupus familiaris] GPAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAMQFGHVTKICTQCEMEHSADGLMEQMCSSDFVVKMRIKEIKLENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGASCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >NP_001230335.1 secreted frizzled-related protein 5 precursor [Sus scrofa] AAARGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRLKEIKIESGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAVEPH >XP_002718655.1 PREDICTED: secreted frizzled-related protein 5 [Oryctolagus cuniculus] -AAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKLENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_024109539.1 secreted frizzled-related protein 5 [Pongo abelii] AAAGGVLGALHWAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVAKMRIKEIMIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_010712904.1 secreted frizzled-related protein 5 isoform X1 [Meleagris gallopavo] RASGPA--ALALARQHYDYYGRGRFYGREPQCVDIPADMQVGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHADTQLFLCSLFAPVCLDRPIYPCRSLCEVVRDACAPVMESYGFPWPEMLHCGKFPSDHDLCITVQFGNVPKICTQCEMEHKADGMMQQMCSSDFVVKMRIKEVIEENGERRLVAAQ-KKKVLKLGPLKRKDTKKMVLHMRNTGSCGSFLVLGRKVGGRLLLLAIYPWRKHNKEMKFAVKFMFSYPCPLYHPLLYGAGQ-H >XP_003825732.4 secreted frizzled-related protein 5 [Pan paniscus] AAAGGVLGALHWAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_023096575.1 secreted frizzled-related protein 5 [Felis catus] AAAGGALGALHGAPEENDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGASCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_027816131.1 secreted frizzled-related protein 5 [Ovis aries] AAAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_004049962.2 secreted frizzled-related protein 5 [Gorilla gorilla gorilla] AAAGGVLGALHWAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_004077190.1 secreted frizzled-related protein 5 [Oryzias latipes] SSFGLA---LLLTIDEYDYYSNGRFYTKQPQCVDIPSDLRVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRNSCAPVMETYGFPWPDMLTCDKFPIDNDLCIPMQFAGVPKVCPPCDNELKTDNIMEHYCASDFVLKMKIKEVKKEKADRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCSHFLVMGRKVDQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHSVFQ------ >XP_005507091.1 secreted frizzled-related protein 5 [Columba livia] LAANKGQGGVGPAAALPDTFL---LLGKREHCLDIPPDMQVGYKRMRLPNLLEHESMAEAKQQASSWVPLLAKQCHTDTQLFLCSLFAPVCLDRPVYPCRSLCEVVRDSCAPVMESYGFPWPEMLHCGKFPPDHELCIAVQFGNVSKICTQCEMEHKADGMMEQMCSSDFVVKMRIKEITEENGERRLVAAQ-KKKVLKLGPLKRKDTKKMVLHMRNAGACGSFLVMGRKVGGRLLLLAVYPWQKHNKEMKFAVKFMFSYPCPLYHP---GAGQ-H >XP_005698444.3 PREDICTED: secreted frizzled-related protein 5 [Capra hircus] AAAGGALGALHGAPEEYDYYGHGRSHSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRKVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_006033802.2 secreted frizzled-related protein 5 [Alligator sinensis] AMGGGP---VSGAVPSYEAY--GRFSAKAPQCVDIPGDLQVGYKRMRLPNLLEHDSLAEVKQQAGSWVPLLAKRCHSDTQLFLCALFAPVCLERPVYPCRSLCEVVRDACGPVMESYGFPWPDMLHCAQFPPDHGLCIAVQFGHVPRLCPQCEVEHKADGMMEQMCSSDFVVKLRIKEVVQEGAERRLVAAP-KKKVLKLGPLQRKDERRMVLHMRNAGACGSFLVLGRKAGGRLLLLAIYRWQKRDPEVKFAVKFMFSYPCPLYHPLLLHSAQ-H >XP_015799833.1 PREDICTED: secreted frizzled-related protein 5 [Nothobranchius furzeri] GFFSLA---LLFTIDEYDYYNNGRFYTKQPQCVDIPADLRVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLNCDKFPIDNDLCIPMQFAAVSNVCPPCDNEMKADNIMEHYCASDFALKMKIKEVKKEKGDRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCSNFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHSVFQ------ >XP_020739154.1 secreted frizzled-related protein 5 [Odocoileus virginianus texanus] AAAGGALGALHGAPEEYDYYGHGRSYSKPPQCLDIPADLPVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHSDTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDNDLCIAVQFGHVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDRKLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCGSFLVMGRRVDGQLLLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH >XP_030297987.1 secreted frizzled-related protein 5 [Sparus aurata] GSFSLA---LLFTVDEYDYYSNGRFYTKQPQCVDIPADLRVGYKKMRLPNLLDHETMPEVKQQAGSWVPLLAKRCHADTQVFLCSLFAPVCLDRPIYPCRSLCEAVRDSCAPVMETYGFPWPEMLTCDKFPIDNDLCIPMQFTGVSKVCPPCDNELKADNIMEHYCASDFALKMKIKEVKKEKGDRKLIAAQKKKKVLKQGVLRKKDLKKLTLYIKNGANCSSFLIMGRKVDQQLLLMSIHKWDKKSKELKFAIKYMKSHQCPTYHTVFQ------ >XP_040217204.1 secreted frizzled-related protein 5 [Rana temporaria] FQWNIV---GLVLWEEYDYYSNGRFYTKQSQCVDIPQDLGVGYKKMRLPNLLDHETMPEVKQQASSWVPLLAKRCHRDTQLFLCSLFAPICLERPIYPCRSLCEVVRDSCAPVMESYGFPWPEMLNCNKFPIDNDLCIAVQFGSVTKICTQCEIEQKSETMRVQYCASDFVVRMRIKEVKIENGDRKLIAAQKKKKVLKAGKLKRKEFRKLVLYIKNAAGCGSFLIMGRKVDNKLLLTAIYKWDKKSKDMKYAVNFMFTYPCS--ETISHSAGS-H >XP_781087.2 secreted frizzled-related protein 5 isoform X2 [Strongylocentrotus purpuratus] ------DMAMLGVNYPLDL--SGR--PKETDCVDIPEDLSIGYTRMRMPNLLEHDSLDEVRNQAKSWVPLLLQRCHEGTQLFLCTLFAPVCLDRPIYPCRSLCEEVQAGCGPLMESNCFPWPAMLQCDKFPEDNDLCIRLNMRNYMMHFTQCHDDSLEDTLLRKFCNSDFVLKVKIKTIRESKDGKKYIGDPNKLEVLKQGSLKTKDLQRLTFYVREGANCNYLLVMGSKKNRKLFMTFVHSWEK-TRDFRRAIKGFEPDMCETNTPVNDGVYTTH >XP_039270710.1 secreted frizzled-related protein 1-like isoform X2 [Styela clava] -----M--LLNALLNTFGAFTTASPFAKNFVCEPIPHSLKIAYNQMRLPNLLGHETMDEVKQQAASWVPLLNKRCHKDLQRLLCSLFSPVCIPEPIYPCQSLCQAVKGACEPVMQKVGYPWPDMLSCDKFR-DNDMCVPQECHHSTPICPACGNELDAETILNLYCAVEFVLKVKIRSVKTSRKDLKLMADKRKRVIYQEGSLKRKDLRKLTLLIRGGKSCDFYLVMGGKVGRKLLVSAIYRWPKKLKMLRRLSKKFTPDLCS------------- >XP_038052835.1 secreted frizzled-related protein 5-like isoform X2 [Patiria miniata] ------MAACLAQMFAMDL--SGR--ITKPTCVDIPVDLAIGYNRMRMPNLLDHDSIFEVKDQSQGWIPLLMVNCDNDTQLFLCSLFSPVCLDRPIYPCRSLCRKVRQNCEPIMLRNCFPWPSMLECDRFPEDNGLCIQSEMRQVGSLFTQCHDDADAASIVEYFCNADFVLKMKLKEVKETDEGMRYVGDPTKFAVIKQGSLKQKDLAKMRFWTREGANCENFLVMGHRDGKKLYMTYVHIWTK-SRELRNANKQF-AQPCPRERPGRDGAAETT >NP_500977.2 Secreted frizzled-related protein 1 [Caenorhabditis elegans] -----M--LFAFSVYLEDSWASER--PVGPKCVDIPSNLSIEYTQMRLPNILEHETVSEAIHASKDWESLLRLNCHPDTQRFLCSLFAPVCLDRLILPCKSLCMAVKQGCENRMANYGFPWPEMLSCEKFE-DDDMCIKPMQPASSTTCTACSQVATYENLVDQFCRSHLVLKAKV--IRDSPTHIRVR----NGRSLKKGERRRGVSDEIRLSSESDGSCEKLLVMARQPDGKYLANLVLPWQK-EKNFKRAIHQFQRLNCQSRRPHYYEMRR-H >XP_031565722.1 secreted frizzled-related protein 1-like [Actinia tenebrosa] --------RCLLLLFHVAL--CYR--TRSHHCVDITSNTALGYDKMMLPNFLRHDTAMEVRRELAQWSPLVGSGCHPYLKHFLCSVFAPVCMLELIPPCRSLCSMVQNSCEPLMRRHNYTWPSMLDCRKYP-ENSMCVKIETPTTTTVCEEDGSNVPLDELQKKFCDSDFAMRARVSEKKMKDGYLILKAT--AIKSLK-GSLKRDQLQRLRIPNMESRNCKQFLILGTKRGRRMIVTYLMKWKD-FRNMRRKIKE---KACRM------------ >XP_006568530.1 frizzled-2 [Apis mellifera] -RY---FSVAVFSVHTKDPL-HGR-------CE--PITINIPYNETIMPNLMNHQKQEDAGQEVHQFAPLVKMKCSPDLRFFLCTVYAPVCTDRAIPPCRSLCESARAGCERLMNSFGFAWPDNLDCSKLPENGELCVGHNETTVAEFQPSWGPKTYGSGFMLGARDFGFVCPMQFKVPHELGYSLKVG----DKVELNCGAFTERERRFSRIWVGNSIACASTITQGKHELCTVLFMVLYKWGHEAIEANSQYFHLAAWAAPVEGDILSGVCYVG >CAA38459.1 frizzled [Drosophila melanogaster] QRYDQSRSGGGLMATELDGL-HNR-------CE--PITISIPYNMTIMPNLIGHTKQEEAGLEVHQFAPLVKIGCSDDLQLFLCSLYVPVCTERPIPPCRSLCESARV-CEKLMKTYNFNWPENLECSKFPVHGDLCVAENTTSVAKVTTR----KHQTGVERPHRNIGFVCPVQLKTPLGMGYELKVG----GKDLHDCGAFPERERTVLRYWVGDSVSCMSTITQGQTTSCTVLFMALYKWGHEAIENKSHLFHLVAWAVPVEGMYLWQFHTIN >CAE1258256.1 FZD4 [Sepia pharaonis] -NYDTMSFSPISSILLKDGLFSGRPAEVVRTCD--PIEIPQGYNVTGMPNLAGNDMQRDAQLQLNTFNPLIQYGCSSQLTFFLCSVFVPMCTKDPIGPCRPMCESVKRKCQPVLQEFGFSWPDILNCTKFPPRNHMCMDGPGENRSGVGRT-GKNRNANVGGWQHGKPPFPNMHRVGTCLHMRHPENYVYVNRERCALRCGRFSYNDKEFSDVWMRQNISCSILIQEGENTDCAIVFLLLYKWSHEALQVHSSYFHLTAWAIPVDADELTGICFVG
PhyML tree of selected proteins (CAE1258256_1_FZD4__Sepia_pharaonis_:1.3408114,(XP_039270710_1_secreted_frizzled_related_protein_1_like_isoform_X2__Styela_clava_:0.78118249,(((NP_500977_2_Secreted_frizzled_related_protein_1__Caenorhabditis_elegans_:1.29118263,XP_031565722_1_secreted_frizzled_related_protein_1_like__Actinia_tenebrosa_:1.61147283):0.26175559,(XP_038052835_1_secreted_frizzled_related_protein_5_like_isoform_X2__Patiria_miniata_:0.54665976,XP_781087_2_secreted_frizzled_related_protein_5_isoform_X2__Strongylocentrotus_purpuratus_:0.43532941):0.38619713):0.16125974,(KYO28472_1_secreted_frizzled_related_protein_1__Alligator_mississippiensis_:0.42562768,(((((XP_543955_4_secreted_frizzled_related_protein_5_isoform_X3__Canis_lupus_familiaris_:0.02054432,(XP_023096575_1_secreted_frizzled_related_protein_5__Felis_catus_:0.00399841,(XP_002718655_1_PREDICTED__secreted_frizzled_related_protein_5__Oryctolagus_cuniculus_:0.0040585,(NP_776886_1_secreted_frizzled_related_protein_5_precursor__Bos_taurus_:0.00799484,((NP_001230335_1_secreted_frizzled_related_protein_5_precursor__Sus_scrofa_:0.01613436,(XP_005698444_3_PREDICTED__secreted_frizzled_related_protein_5__Capra_hircus_:0.00399445,((KAB0383808_1_hypothetical_protein_FD755_005725__Muntiacus_reevesi_:0.00000001,XP_020739154_1_secreted_frizzled_related_protein_5__Odocoileus_virginianus_texanus_:0.00000001):0.00399997,(sp_Q5T4F7_SFRP5_HUMAN_Secreted_frizzled_related_protein_5_OS_Homo_sapiens_OX_9606_GN_SFRP5_PE_2_SV_3:0.00400637,(XP_024109539_1_secreted_frizzled_related_protein_5__Pongo_abelii_:0.00801526,(XP_003825732_4_secreted_frizzled_related_protein_5__Pan_paniscus_:0.00000001,(XP_016774536_1_secreted_frizzled_related_protein_5__Pan_troglodytes_:0.00000001,XP_004049962_2_secreted_frizzled_related_protein_5__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.00802456):0.00000001):0.00000001):0.00000001,XP_027816131_1_secreted_frizzled_related_protein_5__Ovis_aries_:0.00000001):0.00000001):0.00000001):0.00399797):0.00000001):0.01016877,(NP_061250_2_secreted_frizzled_related_protein_5_precursor__Mus_musculus_:0.00801443,NP_001101061_1_secreted_frizzled_related_protein_5_precursor__Rattus_norvegicus_:0.00400592):0.01811657):0.11772366,(XP_006033802_2_secreted_frizzled_related_protein_5__Alligator_sinensis_:0.2448518,(XP_005507091_1_secreted_frizzled_related_protein_5__Columba_livia_:0.14441176,(XP_010712904_1_secreted_frizzled_related_protein_5_isoform_X1__Meleagris_gallopavo_:0.01248122,NP_001305376_1_secreted_frizzled_related_protein_5_precursor__Gallus_gallus_:0.01600963):0.04380808):0.04691691):0.13118265):0.16556403,(XP_040217204_1_secreted_frizzled_related_protein_5__Rana_temporaria_:0.02649627,NP_001083946_1_secreted_frizzled_related_protein_5_L_homeolog_precursor__Xenopus_laevis_:0.03427817):0.18397078):0.21739697,(XP_015799833_1_PREDICTED__secreted_frizzled_related_protein_5__Nothobranchius_furzeri_:0.01356556,(tr_F1QJG6_F1QJG6_DANRE_Secreted_frizzled_related_protein_5_OS_Danio_rerio_OX_7955_GN_sfrp5_PE_3_SV_1:0.08245934,(XP_030297987_1_secreted_frizzled_related_protein_5__Sparus_aurata_:0.01304037,XP_004077190_1_secreted_frizzled_related_protein_5__Oryzias_latipes_:0.05175325):0.00638697):0.0118829):0.03768562):0.11424075):0.23719189):0.1003747):2.11662244,(XP_006568530_1_frizzled_2__Apis_mellifera_:0.34639008,CAA38459_1_frizzled__Drosophila_melanogaster_:0.52624282):0.56835613);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)