Click here to access PB0113 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0113 P02462 Collagen alpha-1(IV) chain COL4A1 BSVD, BSVD1, COL4A1s, PADMAL, RATOR, collagen type IV alpha 1 chain Homo_sapiens Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.

DomainsGene Ontology
PF01391 (16_Collagen)
PF01413 (2_C4)
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005515 (enables) protein binding
GO:0030020 (enables) extracellular matrix structural constituent conferring tensile strength
GO:0048407 (enables) platelet-derived growth factor binding
GO:0001525 (involved in) angiogenesis
GO:0001569 (involved in) branching involved in blood vessel morphogenesis
GO:0007420 (involved in) brain development
GO:0007528 (involved in) neuromuscular junction development
GO:0030198 (involved in) extracellular matrix organization
GO:0030855 (involved in) epithelial cell differentiation
GO:0038063 (involved in) collagen-activated tyrosine kinase receptor signaling pathway
GO:0048514 (involved in) blood vessel morphogenesis
GO:0061304 (involved in) retinal blood vessel morphogenesis
GO:0061333 (involved in) renal tubule morphogenesis
GO:0071230 (involved in) cellular response to amino acid stimulus
GO:0071711 (involved in) basement membrane organization
GO:0005615 (is active in) extracellular space
GO:0031012 (is active in) extracellular matrix
GO:0005576 (located in) extracellular region
GO:0005604 (located in) basement membrane
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0005581 (part of) collagen trimer
GO:0005587 (part of) collagen type IV trimer

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)