PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0111 | Q9NS15 | Latent-transforming growth factor beta-binding protein 3 | LTBP3 | DASS, GPHYSD3, LTBP-3, LTBP2, STHAG6, pp6425 | Homo_sapiens | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. |
Domains | Gene Ontology |
PF00683 (4_TB) PF07645 (9_EGF_CA) PF12662 (2_cEGF) |
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding GO:0019838 (enables) growth factor binding GO:0050431 (enables) transforming growth factor beta binding GO:0001501 (involved in) skeletal system development GO:0007179 (involved in) transforming growth factor beta receptor signaling pathway GO:0030502 (involved in) negative regulation of bone mineralization GO:0032331 (involved in) negative regulation of chondrocyte differentiation GO:0036363 (involved in) transforming growth factor beta activation GO:0045780 (involved in) positive regulation of bone resorption GO:0046849 (involved in) bone remodeling GO:0048251 (involved in) elastic fiber assembly GO:0060349 (involved in) bone morphogenesis GO:0060430 (involved in) lung saccule development GO:1902462 (involved in) positive regulation of mesenchymal stem cell proliferation GO:2000741 (involved in) positive regulation of mesenchymal stem cell differentiation GO:0005576 (located in) extracellular region GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |