PB0108
DATABASE


Click here to access PB0108 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0108 P07996 Thrombospondin-1 THBS1 THBS, THBS-1, TSP, TSP-1, TSP1 Homo_sapiens Ligand for CD36 mediating antiangiogenic properties. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity).

DomainsGene Ontology
PF00090 (3_TSP_1)
PF00093 (VWC)
PF02412 (7_TSP_3)
PF05735 (TSP_C)
GO:0043406 (acts upstream of) positive regulation of MAP kinase activity
GO:2001027 (acts upstream of or within) negative regulation of endothelial cell chemotaxis
GO:0001786 (enables) phosphatidylserine binding
GO:0001968 (enables) fibronectin binding
GO:0005178 (enables) integrin binding
GO:0005201 (enables) extracellular matrix structural constituent
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0008201 (enables) heparin binding
GO:0017134 (enables) fibroblast growth factor binding
GO:0030169 (enables) low-density lipoprotein particle binding
GO:0042802 (enables) identical protein binding
GO:0043236 (enables) laminin binding
GO:0043394 (enables) proteoglycan binding
GO:0050431 (enables) transforming growth factor beta binding
GO:0050840 (enables) extracellular matrix binding
GO:0070051 (enables) fibrinogen binding
GO:0070052 (enables) collagen V binding
GO:0001666 (involved in) response to hypoxia
GO:0001937 (involved in) negative regulation of endothelial cell proliferation
GO:0001953 (involved in) negative regulation of cell-matrix adhesion
GO:0002040 (involved in) sprouting angiogenesis
GO:0002544 (involved in) chronic inflammatory response
GO:0002581 (involved in) negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605 (involved in) negative regulation of dendritic cell antigen processing and presentation
GO:0006954 (involved in) inflammatory response
GO:0006955 (involved in) immune response
GO:0006986 (involved in) response to unfolded protein
GO:0007155 (involved in) cell adhesion
GO:0008284 (involved in) positive regulation of cell population proliferation
GO:0008285 (involved in) negative regulation of cell population proliferation
GO:0009410 (involved in) response to xenobiotic stimulus
GO:0009612 (involved in) response to mechanical stimulus
GO:0009749 (involved in) response to glucose
GO:0010595 (involved in) positive regulation of endothelial cell migration
GO:0010596 (involved in) negative regulation of endothelial cell migration
GO:0010748 (involved in) negative regulation of long-chain fatty acid import across plasma membrane
GO:0010751 (involved in) negative regulation of nitric oxide mediated signal transduction
GO:0010754 (involved in) negative regulation of cGMP-mediated signaling
GO:0010757 (involved in) negative regulation of plasminogen activation
GO:0010759 (involved in) positive regulation of macrophage chemotaxis
GO:0010763 (involved in) positive regulation of fibroblast migration
GO:0016477 (involved in) cell migration
GO:0016525 (involved in) negative regulation of angiogenesis
GO:0018149 (involved in) peptide cross-linking
GO:0030194 (involved in) positive regulation of blood coagulation
GO:0030335 (involved in) positive regulation of cell migration
GO:0030511 (involved in) positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032026 (involved in) response to magnesium ion
GO:0032570 (involved in) response to progesterone
GO:0032695 (involved in) negative regulation of interleukin-12 production
GO:0032760 (involved in) positive regulation of tumor necrosis factor production
GO:0032914 (involved in) positive regulation of transforming growth factor beta1 production
GO:0033574 (involved in) response to testosterone
GO:0034605 (involved in) cellular response to heat
GO:0034976 (involved in) response to endoplasmic reticulum stress
GO:0040037 (involved in) negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327 (involved in) positive regulation of phosphorylation
GO:0043032 (involved in) positive regulation of macrophage activation
GO:0043066 (involved in) negative regulation of apoptotic process
GO:0043154 (involved in) negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536 (involved in) positive regulation of blood vessel endothelial cell migration
GO:0043537 (involved in) negative regulation of blood vessel endothelial cell migration
GO:0043652 (involved in) engulfment of apoptotic cell
GO:0045727 (involved in) positive regulation of translation
GO:0045766 (involved in) positive regulation of angiogenesis
GO:0048266 (involved in) behavioral response to pain
GO:0048661 (involved in) positive regulation of smooth muscle cell proliferation
GO:0050921 (involved in) positive regulation of chemotaxis
GO:0051592 (involved in) response to calcium ion
GO:0051895 (involved in) negative regulation of focal adhesion assembly
GO:0051897 (involved in) positive regulation of protein kinase B signaling
GO:0051918 (involved in) negative regulation of fibrinolysis
GO:0071356 (involved in) cellular response to tumor necrosis factor
GO:0071363 (involved in) cellular response to growth factor stimulus
GO:0071636 (involved in) positive regulation of transforming growth factor beta production
GO:0090051 (involved in) negative regulation of cell migration involved in sprouting angiogenesis
GO:1902043 (involved in) positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1903588 (involved in) negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
GO:1903671 (involved in) negative regulation of sprouting angiogenesis
GO:2000353 (involved in) positive regulation of endothelial cell apoptotic process
GO:2000379 (involved in) positive regulation of reactive oxygen species metabolic process
GO:2001237 (involved in) negative regulation of extrinsic apoptotic signaling pathway
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005737 (located in) cytoplasm
GO:0005783 (located in) endoplasmic reticulum
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0009897 (located in) external side of plasma membrane
GO:0009986 (located in) cell surface
GO:0016529 (located in) sarcoplasmic reticulum
GO:0030141 (located in) secretory granule
GO:0031012 (located in) extracellular matrix
GO:0031091 (located in) platelet alpha granule
GO:0031093 (located in) platelet alpha granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix
GO:0070062 (located in) extracellular exosome
GO:0005577 (part of) fibrinogen complex

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences


Created by Puigbo and Nakamura @ University of Turku (2022)