PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0107 | P14780 | Matrix metalloproteinase-9 | MMP9 | CLG4B, GELB, MANDP2, MMP-9 | Homo_sapiens | Degrades fibronectin but not laminin or Pz-peptide. |
Domains | Gene Ontology |
PF00040 (3_fn2) PF00045 (4_Hemopexin) PF00413 (Peptidase_M10) PF01471 (PG_binding_1) |
GO:0004175 (enables) endopeptidase activity
GO:0004222 (enables) metalloendopeptidase activity GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0005518 (enables) collagen binding GO:0008233 (enables) peptidase activity GO:0008237 (enables) metallopeptidase activity GO:0008270 (enables) zinc ion binding GO:0016787 (enables) hydrolase activity GO:0042802 (enables) identical protein binding GO:0046872 (enables) metal ion binding GO:0001501 (involved in) skeletal system development GO:0001503 (involved in) ossification GO:0001934 (involved in) positive regulation of protein phosphorylation GO:0006508 (involved in) proteolysis GO:0007566 (involved in) embryo implantation GO:0022617 (involved in) extracellular matrix disassembly GO:0030198 (involved in) extracellular matrix organization GO:0030225 (involved in) macrophage differentiation GO:0030335 (involved in) positive regulation of cell migration GO:0030574 (involved in) collagen catabolic process GO:0034614 (involved in) cellular response to reactive oxygen species GO:0035987 (involved in) endodermal cell differentiation GO:0043065 (involved in) positive regulation of apoptotic process GO:0043066 (involved in) negative regulation of apoptotic process GO:0043388 (involved in) positive regulation of DNA binding GO:0045742 (involved in) positive regulation of epidermal growth factor receptor signaling pathway GO:0048013 (involved in) ephrin receptor signaling pathway GO:0050900 (involved in) leukocyte migration GO:0051549 (involved in) positive regulation of keratinocyte migration GO:0071276 (involved in) cellular response to cadmium ion GO:0071492 (involved in) cellular response to UV-A GO:0090200 (involved in) positive regulation of release of cytochrome c from mitochondria GO:0150077 (involved in) regulation of neuroinflammatory response GO:1900122 (involved in) positive regulation of receptor binding GO:1904645 (involved in) response to amyloid-beta GO:1904707 (involved in) positive regulation of vascular associated smooth muscle cell proliferation GO:2000697 (involved in) negative regulation of epithelial cell differentiation involved in kidney development GO:2001243 (involved in) negative regulation of intrinsic apoptotic signaling pathway GO:2001258 (involved in) negative regulation of cation channel activity GO:2001268 (involved in) negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:1904724 (located in) tertiary granule lumen GO:1904813 (located in) ficolin-1-rich granule lumen |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |