Click here to access PB0102 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0102 P10451 Osteopontin SPP1 BNSP, BSPI, ETA-1, OPN, secreted phosphoprotein 1 Homo_sapiens Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.

DomainsGene Ontology
PF00865 (Osteopontin)
GO:0005125 (enables) cytokine activity
GO:0005178 (enables) integrin binding
GO:0005515 (enables) protein binding
GO:0050840 (enables) extracellular matrix binding
GO:0001503 (involved in) ossification
GO:0001649 (involved in) osteoblast differentiation
GO:0006710 (involved in) androgen catabolic process
GO:0006954 (involved in) inflammatory response
GO:0007155 (involved in) cell adhesion
GO:0007165 (involved in) signal transduction
GO:0007566 (involved in) embryo implantation
GO:0010033 (involved in) response to organic substance
GO:0030154 (involved in) cell differentiation
GO:0031214 (involved in) biomineral tissue development
GO:0033280 (involved in) response to vitamin D
GO:0045780 (involved in) positive regulation of bone resorption
GO:0045893 (involved in) positive regulation of transcription, DNA-templated
GO:0046697 (involved in) decidualization
GO:0048545 (involved in) response to steroid hormone
GO:0048685 (involved in) negative regulation of collateral sprouting of intact axon in response to injury
GO:0071394 (involved in) cellular response to testosterone stimulus
GO:2000866 (involved in) positive regulation of estradiol secretion
GO:0005615 (is active in) extracellular space
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0005794 (located in) Golgi apparatus
GO:0031982 (located in) vesicle
GO:0042995 (located in) cell projection
GO:0048471 (located in) perinuclear region of cytoplasm
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)