PB0100

DATABASE

Click here to access PB0100 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0100	P43235	Cathepsin K	CTSK	CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD	Homo_sapiens	Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042).

Domains

Gene Ontology

PF00112 (Peptidase_C1) PF08246 (Inhibitor_I29)

GO:0001968 (enables) fibronectin binding GO:0004197 (enables) cysteine-type endopeptidase activity GO:0004252 (enables) serine-type endopeptidase activity GO:0005515 (enables) protein binding GO:0005518 (enables) collagen binding GO:0008233 (enables) peptidase activity GO:0008234 (enables) cysteine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0043394 (enables) proteoglycan binding GO:0000422 (involved in) autophagy of mitochondrion GO:0001957 (involved in) intramembranous ossification GO:0006508 (involved in) proteolysis GO:0006590 (involved in) thyroid hormone generation GO:0006955 (involved in) immune response GO:0022617 (involved in) extracellular matrix disassembly GO:0030574 (involved in) collagen catabolic process GO:0045453 (involved in) bone resorption GO:0051603 (involved in) proteolysis involved in cellular protein catabolic process GO:0061037 (involved in) negative regulation of cartilage development GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005654 (located in) nucleoplasm GO:0005737 (located in) cytoplasm GO:0005764 (located in) lysosome GO:0005886 (located in) plasma membrane GO:0009897 (located in) external side of plasma membrane GO:0016020 (located in) membrane GO:0016324 (located in) apical plasma membrane GO:0036021 (located in) endolysosome lumen GO:0043202 (located in) lysosomal lumen GO:0043231 (located in) intracellular membrane-bounded organelle

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P43235|CATK_HUMAN Cathepsin K OS=Homo sapiens OX=9606 GN=CTSK PE=1 SV=1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE NWGNKGYILMARNKNNACGIANLASFPKM >tr|F1Q8A0|F1Q8A0_DANRE Cathepsin K OS=Danio rerio OX=7955 GN=ctsk PE=1 SV=1 MGRFGGFPLLVVLWCGLAHSLDNLSLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLF IEAHNKEYELGIHTYDLGMNHFGDMTLEEVAEKVMGLQMPMYRDPANTFVPDDRVGKLPK SIDYRKLGYVTSVKNQGSCGSCWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTENDGC GGGYMTNAFRYVSNNQGIDSEESYPYVGTDQQCAYNTSGVAASCRGYKEIPQGNERALTA AVANVGPVSVGIDAMQSTFLYYKSGVYYDPNCNKEDVNHAVLAVGYGATPRGKKYWIVKN SWGEEWGKKGYVLMARNRNNACGIANLASFPVM
Selected proteins from model organisms >sp|P43235|CATK_HUMAN Cathepsin K OS=Homo sapiens OX=9606 GN=CTSK PE=1 SV=1 MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE NWGNKGYILMARNKNNACGIANLASFPKM >tr|F1Q8A0|F1Q8A0_DANRE Cathepsin K OS=Danio rerio OX=7955 GN=ctsk PE=1 SV=1 MGRFGGFPLLVVLWCGLAHSLDNLSLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLF IEAHNKEYELGIHTYDLGMNHFGDMTLEEVAEKVMGLQMPMYRDPANTFVPDDRVGKLPK SIDYRKLGYVTSVKNQGSCGSCWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTENDGC GGGYMTNAFRYVSNNQGIDSEESYPYVGTDQQCAYNTSGVAASCRGYKEIPQGNERALTA AVANVGPVSVGIDAMQSTFLYYKSGVYYDPNCNKEDVNHAVLAVGYGATPRGKKYWIVKN SWGEEWGKKGYVLMARNRNNACGIANLASFPVM >NP_031828.2 cathepsin K preproprotein [Mus musculus] MWVFKFLLLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCW AFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESC MYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLV VGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFPKM >NP_113748.1 cathepsin K precursor [Rattus norvegicus] MWVFKFLLLPVVSFALSPEETLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHT YELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCW AFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESC MYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLV VGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM >NP_990302.2 cathepsin K precursor [Gallus gallus] MLRLHWLALLALLLPMAAAHLRPEPELDAQWDLWKRTYRKQYNGKEDETSRRLIWEKNLKYIDAHNAEHA LGKHSFQLAMNHLGDMTSEEVVRTMTGLRVPRSRPRPNGTLYVPDWSSRAPAAVDWRRKGYVTPVKNQGQ CGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSNNNGCGGGYMTNAFEYVRLNRGIDSEDAYPYIG QDESCMYSPTGKAAKCRGYREIPEGNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDTSCNPENIN HAVLAVGYGAQKGTKHWIIKNSWGTEWGNKGYVLLARNMNNACGIANLASFPKM >NP_999467.1 cathepsin K precursor [Sus scrofa] MWGLKVVLLLPVMSSALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDEN CMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVL AVGYGIQKGKKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_001171151.1 cathepsin K [Pan troglodytes] MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFEYVQKNRGIDSEDAYPYVGQEESC MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSRGVYFDESCNSDNLNHAVLA VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >NP_001029607.1 cathepsin K precursor [Bos taurus] MPINRMWGLTVLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEAS LGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQ CGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVG QDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLN HAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_038546429.1 cathepsin K isoform X1 [Canis lupus familiaris] MWGLEVLLLLPMASFALYPEEILDTQWDLWKKTYRKQYNSKVDELSRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTLYIPDWESRAPDSVDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQPPF FQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNL NHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >NP_001076110.1 cathepsin K precursor [Oryctolagus cuniculus] MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCW AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGQDESC MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLA VGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM >XP_009242974.1 cathepsin K [Pongo abelii] MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLA VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_008968710.1 cathepsin K [Pan paniscus] MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLA VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_019693361.1 cathepsin K [Felis catus] MWGLKILLLLPTATFALYPEVILDTQWELWKKTYGKQYNNKVDEISRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPPSRSRSNDTLYIPDWESRAPDSIDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDES CMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVL AVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_004002514.1 cathepsin K [Ovis aries] MWGLTVLLLLPVLSFALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRTPDSVDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDEN CMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVL AVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_018877383.1 cathepsin K [Gorilla gorilla gorilla] MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHT YELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCW AFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESC MYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLA VGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_021135601.1 cathepsin K [Columba livia] MGGSWPQNWACGGRSVPPSSVPVPRMWWPALLALLVPAVMAQPQPELDAQWRLWKKTYGKEYNGEADEAA RRLIWEKNLKYINRHNLEHALGVHSFQLAMNHLGDMTSEEVVRTMTGLKVPRGHQRHNGTLYVFFDWTQR APAAVDWRRKGYVTPVKNQGQCGSCWAFSSVGALEGQXXXXXXXXXXXXXXXXXXXXXXXXXTNAFEYVR QNRGIDSEDAYPYIGQDESCMYSPSGKAAKCRGYREIPPGNEKALKRAVARIGPVSVGIDASLPSFQFYS RGVYYDESCNAENINHAVLAVGYGAQKGTKHWIIKNSWGEEWGNKGYVLLARNMNNACGVANLVANLASF PKM >XP_005677713.1 PREDICTED: cathepsin K [Capra hircus] MWGLTVLLLLPILSFALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRTPDSVDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDEN CMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVL AVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_010722261.2 cathepsin K [Meleagris gallopavo] MGAAVGTAIGTTMGAALGTAVAPFGAAEPQGCSPPPLHPQTSEEVVRTMTGLRVPRSRPRPNGTLYIPDW TSRAPPAVDWRRKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSNNNGCGGGY MTNAFEYVRQNRGIDSEDAYPYIGQDESCMYSPTGKAAKCRGYREIPEGNEKALKRAVARIGPVSVGIDA SLPSFQFYSRGVYYDTSCNAENINHAVLAVGYGAQKGTKHWILKNSWGTEWGNKGYVLLARNMNNACGIA NLASFPKM >XP_019334544.1 PREDICTED: cathepsin K [Alligator mississippiensis] MWCVGLFALLLPTAAALLHPDPALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGL HTYELAMNHLGDMTSEEVVQKMMGLKVPLSRPRSNDTLYEPDWTEQVPDAVDWRKKGYVTPVKNQGQCGS CWAFSSVGALEGQLKRRMGKLLSLSPQNLVDCVTNNDGCGGGYMTNAFEYVHTNRGIDSEDAYPYVGQDE SCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAV LAVGYGTQKGAKYWIVKNSWSEEWGNKGYVLMARNMDNACGIANLASFPKM >XP_020767848.1 cathepsin K [Odocoileus virginianus texanus] MWGLTVLLLLPVVSFALYPEEILDTQWELWKKNYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVH TYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRAPDSIDYRKKGYVTPVKNQGQCGSC WAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDEN CMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVL AVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_025050923.1 cathepsin K [Alligator sinensis] MHMAARLLFNPTSSVICAILRHKRLRPRLLQEPSLLCIDPGLPDPDNRMWCVGLFALLLPTAAALLHPDP ALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGLHTYELAMNHLGDMTSEEVVQKM TGLKVPLSRPRSNDTLYEPDWTEQVPDAVDWRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRMGKLL SLSPQNLVDCVTNNDGCGGGYMTNAFEYVHTNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEG NEKALKRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGTQKGAKYWIVKNSWSE EWGNKGYVLMARNMDNACGIANLASFPKM >XP_030856413.1 cathepsin L1-like [Strongylocentrotus purpuratus] MSNLTFLVAMGLVACAAAAFVKPTSPDLDSRWLEWKIAHTKSYTNDMNELERRLVWEENVKMINMHNLDHSLHKKGFRLG MNEYGDMRLHEVRSTMNGYKSSNVTKVQGSTFLTPSNIQVPDTVDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQTFKK TSKLVSLSEQNLVDCSRTEGNMGCEGGLMDQGFQYVIDNHGIDSEDCYPYDAEDETCHYKASCDSAEVTGFTDVTSGDEQ ALMEAVASVGPVSVAIDASHQSFQLYESGVYDEPECSSSELDHGVLVVGYGTDGGKDYWLVKNSWGETWGLSGYIKMSRN KSNQCGIATSASYPLV >XP_031558775.1 cathepsin L1-like [Actinia tenebrosa] MKLLVLVCVLSVAVANGFVLKFEQDETQWQAWKNFHGKKYTTDLEESSRKAIWKNNLRKITQHNSEGHSYTLAMNHLGDL TQDEFRYFFTGMKSHYSNYTQRTGSAFLAPSNIKLPDEVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQHFKKTGKLV SLSEQNLVDCSTSYGNHGCQGGLMDNAFRYIKANGGIDTEASYPYQAENEKCRYKSSDVGAXDTGFVDIPEGDENSLKTA AGTVGPISVAIDAGHMSFQFYHTGVYNNPSCSSTRLDHGVLVAGYGTYQGKDYWLVKNSWGARWGMEGYIMMSRNKNNQC GIATKASYPLV >XP_038045514.1 procathepsin L-like [Patiria miniata] MMRVAVFCALMVVALGMPFNFNTDLDGEWELFKKVHNKRYSGFGEEANRRSIFESNVKLITMHNLEYDLGNHTYRLGMNF YGDMTGKEFTQVMNGYKTRANPPKATMTFREPQNVQYPTTVDWRTKGYVTPVKNQEQCGSCWAFSATGSLEGQNFAKTKV LPDLSEQNLVDCSYVEGDDGCNGGLMDDAFKYVISNKGIDKESCYVYKAKDENKCHYNASEECITGHCTGFVDVPTGNET ALMAAAATIGPISVAIDASHNSFQLYSEGVYNEPECSPTELDHGVLVVGYGVDQGKDYWLVKNSWGASWGMQGYIMMSRN KNNQCGIATSASYPLV >XP_039258216.1 procathepsin L-like [Styela clava] MKIFMILTVCFAAVSASRLFQSEWEAWKGEHGKSYSYEEENKRQYIWEKNLKKVVDHNMEADNGIHTYRLGMNQFADMDE DEWRSLVLGHVTRPANQMSYCNMTYEMSDPRADDTVDWRTKGYVTPVKNQLQCGSCWAFSTTGSIEGQHFKKTGMLVSLS EQNLIDCSTPEGDHGCHGGLMDNAFKYIVMNGGVDTESSYPYMAKDETMCKFNKMNIGATITGCVDIAHGDEMSLKSAVM RVGPISVAIDAGHSSFQLYKSGVYTSMECSSTKLDHGVLAVGYGTEMGKDYWLVKNSWGEMWGMEGYIMMARNSNNMCGI ATQASYPTV >CAE1309900.1 CTSL [Sepia pharaonis] MFEHNCFFLSSVVSHVLVLLRFKFYQPLCSTPLSCSLSPLSLSLSLSPPLSPLSVSLLSSLSPLSVSLLSLSCLSPLSLP LFRRFVSYGLKMKCFFALFALLAVSTASIITNPKLDKLWEDFKTQYWKNYESANTESLRRLIWEKNFNRVIVHNSHADNG LQTYWLGINEYADMLGYEFVRMMNGLLPRNLTMHRPEFTVTDDDVSKLPSEVDWRQQGYVTPVKNQGQCGSCWAFSTTGS LEGQHFKKTKNLISLSEQDLVDCSRDCGNLGCNGGLMDQAFTCIKKHKGIMLEEDYPYEGHDGKCRFDVSKVAATVRGYV DVKSGDEKALQKAVATVGPISVAIDASHFSFQLYSHGVYKEPSCSSTRLDHGVLVVGYGTKNGEAYWLVKNSWGKSWGMH GYIMMARNHNNMCGIATQASYPLV >XP_006557802.1 cathepsin L1 [Apis mellifera] MKLFLILFITIFTTAHAVSFFELVNQEWMTFKMEHKKVYKSDVEERFRMKIFMDNKHKIAKHNSNYEMKKVSYKLKMNKY GDMLHHEFVNILNGFNKSINTQLRSERLPVGASFIEPANVVLPKKVDWRKEGAVTPVKDQGHCGSCWSFSATGALEGQHF RRTGVLVSLSEQNLIDCSGKYGNNGCNGGLMDQAFQYIKDNKGLDTEASYPYEAENDKCRYNPANSGAIDVGYIDIPTGD EKLLKAAVATIGPVSVAIDASHQSFQFYSEGVYYEPECSSEELDHGVLVIGYGTNENGQDYWLVKNSWGETWGNNGYIKM ARNKLNHCGIASSASYPLVGSKGLL >NP_725347.1 cysteine proteinase-1, isoform A [Drosophila melanogaster] MRTAVLLPLLALLAVAQAVSFADVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNK YADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQ HFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQ GDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFI KMLRNKENQCGIASASSYPLV >NP_001256718.1 Cathepsin L-like [Caenorhabditis elegans] MNRFILLALVAAVVAVNSAKLSRQIESAIEKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGL NHIADLPFSQYRKLNGYRRLFGDSRIKNSSSFLAPFNVQVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARK LGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEE QLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIVKNSWGAGWGEKGYIRIAR NRNNHCGVATKASYPLV >KAB0356916.1 hypothetical protein FD754_001072 [Muntiacus muntjak] MWGLTVLLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNHLG DMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRAPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKL LNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAV ARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACG IANLASFPKM >XP_043313580.1 cathepsin K [Cervus canadensis] MWGLTVLLLLPVVSFALYPEEILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNHLG DMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKL LNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAV ARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACG IANLASFPKM >XP_040189617.1 cathepsin K-like [Rana temporaria] MYWIYLLSIALPLVRGTLYWGDVLNSEWELWKKTHDKQYNGQLDETKRRQIWEKNLKLITTHNIEYSQGKHTYDLAMNHL GDMTSEEVVQTMTGLRVPSNRQSNNTYEPDWTTRIPKYIDYRKKGYVTPVQNQGACGSCWAFSSVGALEGQLMKKTGDLV SLSPQNLVDCDADNYGCQGGYMTNAFGYVRDNNGIDSDAIYPYIGQDEGCLYKPSGKAAGCKGFKEIPIGDEKALKRAVA QVGPVSVSIDASQPSFQFYNKGVYYDKNCDPEGINHAILAVGYGNLKGTKHWIVKNSWGTQWGRKGFALLARDKKNACGI ANLASFPLM >XP_018088930.1 cathepsin K [Xenopus laevis] MRWFSLLSFVLSLVKIGLCQDNSLDSKWELWKKTYHKQYNGQLDETRRRHIWEKNLNLISHHNKEFSQGMHTYDLAMNHL GDMTSEEVVQKMMGLKVPPNHRPNNTYIPDRTARVPEYIDYRKRGYVTPVQNQGVCGSCWAFSSVGALEGQLKKKTGNLV SLSPQNLVDCDTDNYGCQGGYMTNAFGYVRDNGGIDSDAEYPYIGQDEGCHYNPTEKAATCKGYKEIPIGSEKALKRAVA HVGPVSVSIDASLPSFQFYNKGVYYDESCNPEAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGI TTLASFPVM >XP_015805372.1 PREDICTED: cathepsin K-like [Nothobranchius furzeri] MLSLVCVLLLAVSARGHLDEALLDAQWEHWKMTHSKEYNGLDEEGIRRAIWEKNMRMVEAHNQEAALGMHSYELGMNHLG DMTSEEVMEKMTGLLVPMNREQSFTMTLNESVSKLPKSIDYRRKGMVSSVKNQGSCGSCWAFSSAGALEGQLAKKTGQLV DLSPQNLVDCVKENDGCGGGYMTNAFNYVKDNGGIDSEEAYPYVGEEQLCRYNSSGMAAQCKGYVEVPKGSEHALAMALF KAGPVSVGIDATQPSFQLYRKGIYYDTNCNKEDINHAVLAVGFGVSPKGKKYWIVKNSWGEEWGNNGYILMARNRGNLCG IANLASYPIM >XP_030250720.1 cathepsin K-like isoform X1 [Sparus aurata] MMLQCVCLLLLAASALGHLDETTLDHQWDEWKLTHRREYNGLGEEEIRRAIWEKNMRMIDAHNQEAALGMHSYELGMNHL GDMTSEEVSEKMTGLQIPVNRERGFTMDLDDNVTKLPKYIDYRKRGMVTPVKDQGSCGSCWAFSSAGALEGQLAKTTGTL RDLSPQNLVDCVSENQGCGGGYMTNAFKYVQDNGGIDSEEAYPYAGVDQPCRYNSSGMAAECRGYKEIPEGNEHALAVAL YKVGPVSVGIDATQSSFQFYSKGVYYDPNCNKDDINHAVLAVGYGVSVKGKKYWIVKNSWSENWGRQGYILMARNRGNLC GIANLASYPIM >XP_004078392.1 cathepsin K [Oryzias latipes] MWSCTCVLLLLSASVMSQMDETTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQF GDMTQEEVVERMTGLQMPLNPEPRVPMETDGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNL VDLSPQNLVDCVTENDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVAL FKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIVKNSWGETWGNKGYVLMARNRGNVC GIANLASYPVM
Mafft alignment of selected proteins >sp|P43235|CATK_HUMAN Cathepsin K OS=Homo sapiens OX=9606 GN=CTSK PE=1 SV=1 ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALY-----PEE ILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSHSRSNDTLYI-PEWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QEES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >tr|F1Q8A0|F1Q8A0_DANRE Cathepsin K OS=Danio rerio OX=7955 GN=ctsk PE=1 SV=1 ------------------------------------------------------------ -------------------------------MGRFGGFPLLVVLWCGLAHSL-----DNL SLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLFIEAHNKEYELGIHTYDLGMNH--- -----FGDMTLEEVAEKVMGLQMP------MYR-DPANTFVP-DDRVGKLPKSIDYRKLG YVTSVKNQGSCGSCWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTE--NDGCGGGYMT NAFRYVSNNQGIDSEESYPYVG-----TDQQ-CAYNTSG--VAASCRGYKEIPQGNERAL TAAVANVGPVSVGIDAMQSTFLYYKSGVYYDPNCNKEDVNHAVLAVGYGATPRGKKYWIV KNSWGEEWGKKGYVLMARNRNNACG----IANLASFPVM------ >NP_031828.2 cathepsin K preproprotein [Mus musculus] ------------------------------------------------------------ ---------------------------------MWVFKF--LLLPMVSFALS-----PEE MLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLRIP------PSRSYSNDTLYT-PEWEGRVPDSIDYRKKG YVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTE--NYGCGGGYMT TAFQYVQQNGGIDSEDAYPYVG-----QDES-CMYNATA--KAAKCRGYREIPVGNEKAL KRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQ-KGSKHWII KNSWGESWGNKGYALLARNKNNACG----ITNMASFPKM------ >NP_113748.1 cathepsin K precursor [Rattus norvegicus] ------------------------------------------------------------ ---------------------------------MWVFKF--LLLPVVSFALS-----PEE TLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNH--- -----LGDMTSEEVVQKMTGLRVP------PSRSFSNDTLYT-PEWEGRVPDSIDYRKKG YVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSE--NYGCGGGYMT TAFQYVQQNGGIDSEDAYPYVG-----QDES-CMYNATA--KAAKCRGYREIPVGNEKAL KRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQ-KGNKYWII KNSWGESWGNKGYVLLARNKNNACG----ITNLASFPKM------ >NP_990302.2 cathepsin K precursor [Gallus gallus] ---------------------------------------M-------------------- -------------------------------LRLHWLALLALLLPMAAAHLR-----PEP ELDAQWDLWKRTYRKQYNGKEDETSRRLIWEKNLKYIDAHNAEHALGKHSFQLAMNH--- -----LGDMTSEEVVRTMTGLRVP------RSRPRPNGTLYV-PDWSSRAPAAVDWRRKG YVTPVKNQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSN--NNGCGGGYMT NAFEYVRLNRGIDSEDAYPYIG-----QDES-CMYSPTG--KAAKCRGYREIPEGNEKAL KRAVARIGPVSVGIDASLPSFQFYSRGVYYDTSCNPENINHAVLAVGYGAQ-KGTKHWII KNSWGTEWGNKGYVLLARNMNNACG----IANLASFPKM------ >NP_999467.1 cathepsin K precursor [Sus scrofa] ------------------------------------------------------------ ---------------------------------MWGLKV-VLLLPVMSSALY-----PEE ILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------PSHSRSNDTLYI-PDWEGRTPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQ-KGKKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_001171151.1 cathepsin K [Pan troglodytes] ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALY-----PEE ILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSHSRSNDTLYI-PDWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFEYVQKNRGIDSEDAYPYVG-----QEES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSRGVYFDESCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >NP_001029607.1 cathepsin K precursor [Bos taurus] ------------------------------------------------------------ --------------------MP--------INRMWGLTV--LLLPVVSFALY-----PEE ILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYI-PDWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_038546429.1 cathepsin K isoform X1 [Canis lupus familiaris] ------------------------------------------------------------ ---------------------------------MWGLEV-LLLLPMASFALY-----PEE ILDTQWDLWKKTYRKQYNSKVDELSRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------PSHSRSNDTLYI-PDWESRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVGQPPFFQDES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >NP_001076110.1 cathepsin K precursor [Oryctolagus cuniculus] ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALH-----PEE ILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------PSRSHSNDTLYI-PDWEGRTPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NYGCGGGYMT NAFQYVQRNRGIDSEDAYPYVG-----QDES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQ-KGNKHWII KNSWGESWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_009242974.1 cathepsin K [Pongo abelii] ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALY-----PEE ILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSHSRSNDTLYI-PDWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QEES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_008968710.1 cathepsin K [Pan paniscus] ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALY-----PEE ILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSHSRSNDTLYI-PDWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QEES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_019693361.1 cathepsin K [Felis catus] ------------------------------------------------------------ ---------------------------------MWGLKI-LLLLPTATFALY-----PEV ILDTQWELWKKTYGKQYNNKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------PSRSRSNDTLYI-PDWESRAPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_004002514.1 cathepsin K [Ovis aries] ------------------------------------------------------------ ---------------------------------MWGLTV-LLLLPVLSFALY-----PEE ILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYI-PDWEGRTPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_018877383.1 cathepsin K [Gorilla gorilla gorilla] ------------------------------------------------------------ ---------------------------------MWGLKV--LLLPVVSFALY-----PEE ILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSHSRSNDTLYI-PDWEGRAPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QEES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_021135601.1 cathepsin K [Columba livia] ---------------------------------------MGGSWPQNWACGGRSV----- ----------------PPSSVP--------VPRMWWPALLALLVP--AVMAQ-----PQP ELDAQWRLWKKTYGKEYNGEADEAARRLIWEKNLKYINRHNLEHALGVHSFQLAMNH--- -----LGDMTSEEVVRTMTGLKVP------RGHQRHNGTLYVFFDWTQRAPAAVDWRRKG YVTPVKNQGQCGSCWAFSSVGALEGQ------XXXXXXXXXXXXXXXX--XXXXXXXXXT NAFEYVRQNRGIDSEDAYPYIG-----QDES-CMYSPSG--KAAKCRGYREIPPGNEKAL KRAVARIGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGAQ-KGTKHWII KNSWGEEWGNKGYVLLARNMNNACGVANLVANLASFPKM------ >XP_005677713.1 PREDICTED: cathepsin K [Capra hircus] ------------------------------------------------------------ ---------------------------------MWGLTV-LLLLPILSFALY-----PEE ILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYI-PDWEGRTPDSVDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_010722261.2 cathepsin K [Meleagris gallopavo] ------------------------------------------------------------ -----------------------------------------MGAAVGTAIGT-------- ----------------------------------------TMGAALGTAVAPFGAAEPQG CSPPPLHPQTSEEVVRTMTGLRVP------RSRPRPNGTLYI-PDWTSRAPPAVDWRRKG YVTPVKNQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSN--NNGCGGGYMT NAFEYVRQNRGIDSEDAYPYIG-----QDES-CMYSPTG--KAAKCRGYREIPEGNEKAL KRAVARIGPVSVGIDASLPSFQFYSRGVYYDTSCNAENINHAVLAVGYGAQ-KGTKHWIL KNSWGTEWGNKGYVLLARNMNNACG----IANLASFPKM------ >XP_019334544.1 PREDICTED: cathepsin K [Alligator mississippiensis] ------------------------------------------------------------ ---------------------------------MWCVGLFALLLPTAAALLH-----PDP ALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGLHTYELAMNH--- -----LGDMTSEEVVQKMMGLKVP------LSRPRSNDTLYE-PDWTEQVPDAVDWRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKRRMGKLLSLSPQNLVDCVTN--NDGCGGGYMT NAFEYVHTNRGIDSEDAYPYVG-----QDES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGTQ-KGAKYWIV KNSWSEEWGNKGYVLMARNMDNACG----IANLASFPKM------ >XP_020767848.1 cathepsin K [Odocoileus virginianus texanus] ------------------------------------------------------------ ---------------------------------MWGLTV-LLLLPVVSFALY-----PEE ILDTQWELWKKNYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYT-PDWEGRAPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_025050923.1 cathepsin K [Alligator sinensis] M-------------------------------------HMAARLLFNPTSSVICAILRHK RLRPRLLQEPSLLCIDPGLPDP--------DNRMWCVGLFALLLPTAAALLH-----PDP ALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGLHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------LSRPRSNDTLYE-PDWTEQVPDAVDWRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKRRMGKLLSLSPQNLVDCVTN--NDGCGGGYMT NAFEYVHTNRGIDSEDAYPYVG-----QDES-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGTQ-KGAKYWIV KNSWSEEWGNKGYVLMARNMDNACG----IANLASFPKM------ >XP_030856413.1 cathepsin L1-like [Strongylocentrotus purpuratus] ------------------------------------------------------------ -------------------------------MSNLTFLVAMGLVACAAAAFVKP---TSP DLDSRWLEWKIAHTKSYTNDMNELERRLVWEENVKMINMHNLDHSLHKKGFRLGMNE--- -----YGDMRLHEVRSTMNGYKS-------SNVTKVQGSTFL-TPSNIQVPDTVDWRTKG YVTPVKNQGQCGSCWAFSTTGSLEGQTFKKTSKLVSLSEQNLVDCSRTEGNMGCEGGLMD QGFQYVIDNHGIDSEDCYPYDA-----EDET-CHYKASC--DSAEVTGFTDVTSGDEQAL MEAVASVGPVSVAIDASHQSFQLYESGVYDEPECSSSELDHGVLVVGYGTD-GGKDYWLV KNSWGETWGLSGYIKMSRNKSNQCG----IATSASYPLV------ >XP_031558775.1 cathepsin L1-like [Actinia tenebrosa] ------------------------------------------------------------ -------------------------------MK---LLVLVCVLSVAVANGF-VL--KFE QDETQWQAWKNFHGKKYTTDLEESSRKAIWKNNLRKITQHNSEG----HSYTLAMNH--- -----LGDLTQDEFRYFFTGMKSH-----YSNYTQRTGSAFL-APSNIKLPDEVDWRKEG YVTPVKNQGQCGSCWAFSTTGSLEGQHFKKTGKLVSLSEQNLVDCSTSYGNHGCQGGLMD NAFRYIKANGGIDTEASYPYQA-----ENEK-CRYKSSD--VGAXDTGFVDIPEGDENSL KTAAGTVGPISVAIDAGHMSFQFYHTGVYNNPSCSSTRLDHGVLVAGYGTY-QGKDYWLV KNSWGARWGMEGYIMMSRNKNNQCG----IATKASYPLV------ >XP_038045514.1 procathepsin L-like [Patiria miniata] ------------------------------------------------------------ -------------------------------MMRVAVFCALMVVALGMPFNF------NT DLDGEWELFKKVHNKRYSGFGEEANRRSIFESNVKLITMHNLEYDLGNHTYRLGMNF--- -----YGDMTGKEFTQVMNGYKTR------ANP-PKATMTFR-EPQNVQYPTTVDWRTKG YVTPVKNQEQCGSCWAFSATGSLEGQNFAKTKVLPDLSEQNLVDCSYVEGDDGCNGGLMD DAFKYVISNKGIDKESCYVYKA-----KDENKCHYNASEECITGHCTGFVDVPTGNETAL MAAAATIGPISVAIDASHNSFQLYSEGVYNEPECSPTELDHGVLVVGYGVD-QGKDYWLV KNSWGASWGMQGYIMMSRNKNNQCG----IATSASYPLV------ >XP_039258216.1 procathepsin L-like [Styela clava] ------------------------------------------------------------ -------------------------------MK-----IFMILTVCFAAVSA------SR LFQSEWEAWKGEHGKSYSYE-EENKRQYIWEKNLKKVVDHNMEADNGIHTYRLGMNQ--- -----FADMDEDEWRSLVLGHVTR-----PANQMSYCNMTY--EMSDPRADDTVDWRTKG YVTPVKNQLQCGSCWAFSTTGSIEGQHFKKTGMLVSLSEQNLIDCSTPEGDHGCHGGLMD NAFKYIVMNGGVDTESSYPYMA-----KDETMCKFNKMN--IGATITGCVDIAHGDEMSL KSAVMRVGPISVAIDAGHSSFQLYKSGVYTSMECSSTKLDHGVLAVGYGTE-MGKDYWLV KNSWGEMWGMEGYIMMARNSNNMCG----IATQASYPTV------ >CAE1309900.1 CTSL [Sepia pharaonis] MFEHNCFFLSSVVSHVLVLLRFKFYQPLCSTPLSCSLSPLSLSLSLSPPLSPLSVSLL-S SLSPLSVSLLSLSCL-SPLSLPLFRRFVSYGLKMKCFFALFALLAVSTASII-----TNP KLDKLWEDFKTQYWKNYESANTESLRRLIWEKNFNRVIVHNSHADNGLQTYWLGINE--- -----YADMLGYEFVRMMNGLLP-------RNLTMHRPEFTVTDDDVSKLPSEVDWRQQG YVTPVKNQGQCGSCWAFSTTGSLEGQHFKKTKNLISLSEQDLVDCSRDCGNLGCNGGLMD QAFTCIKKHKGIMLEEDYPYEG-----HDGK-CRFDVSK--VAATVRGYVDVKSGDEKAL QKAVATVGPISVAIDASHFSFQLYSHGVYKEPSCSSTRLDHGVLVVGYGTK-NGEAYWLV KNSWGKSWGMHGYIMMARNHNNMCG----IATQASYPLV------ >XP_006557802.1 cathepsin L1 [Apis mellifera] ------------------------------------------------------------ -------------------------------MK-LFLILFITIFTTAHAVSF------FE LVNQEWMTFKMEHKKVYKSDVEERFRMKIFMDNKHKIAKHNSNYEMKKVSYKLKMNK--- -----YGDMLHHEFVNILNGFNKSINTQL-RSERLPVGASFI-EPANVVLPKKVDWRKEG AVTPVKDQGHCGSCWSFSATGALEGQHFRRTGVLVSLSEQNLIDCSGKYGNNGCNGGLMD QAFQYIKDNKGLDTEASYPYEA-----ENDK-CRYNPAN--SGAIDVGYIDIPTGDEKLL KAAVATIGPVSVAIDASHQSFQFYSEGVYYEPECSSEELDHGVLVIGYGTNENGQDYWLV KNSWGETWGNNGYIKMARNKLNHCG----IASSASYPLVGSKGLL >NP_725347.1 cysteine proteinase-1, isoform A [Drosophila melanogaster] ------------------------------------------------------------ -------------------------------MRTAVLLPLLALLAVAQAVSF------AD VVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNK--- -----YADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFI-SPAHVTLPKSVDWRTKG AVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMD NAFRYIKDNGGIDTEKSYPYEA-----IDDS-CHFNKGT--VGATDRGFTDIPQGDEKKM AEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLV KNSWGTTWGDKGFIKMLRNKENQCG----IASASSYPLV------ >NP_001256718.1 Cathepsin L-like [Caenorhabditis elegans] ------------------------------------------------------------ -------------------------------MN---RFILLALVAAVVAVNSAKLSRQIE SAIEKWDDYKEDFDKEYS-ESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNH--- -----IADLPFSQYRK-LNGYRRL-----FGDSRIKNSSSFL-APFNVQVPDEVDWRDTH LVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMD QAFEYIRDNHGVDTEESYPYKG-----RDMK-CHFNKKT--VGADDKGYVDTPEGDEEQL KIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHGDYWIV KNSWGAGWGEKGYIRIARNRNNHCG----VATKASYPLV------ >KAB0356916.1 hypothetical protein FD754_001072 [Muntiacus muntjak] ------------------------------------------------------------ ---------------------------------MWGLTV-LLLLPVVSFALY-----PEE ILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYT-PDWEGRAPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_043313580.1 cathepsin K [Cervus canadensis] ------------------------------------------------------------ ---------------------------------MWGLTV-LLLLPVVSFALY-----PEE ILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNH--- -----LGDMTSEEVVQKMTGLKVP------ASRSRSNDTLYT-PDWEGRTPDSIDYRKKG YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMT NAFQYVQKNRGIDSEDAYPYVG-----QDEN-CMYNPTG--KAAKCRGYREIPEGNEKAL KRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQ-KGNKHWII KNSWGENWGNKGYILMARNKNNACG----IANLASFPKM------ >XP_040189617.1 cathepsin K-like [Rana temporaria] ------------------------------------------------------------ ---------------------------------MYWIYLLSIALPLVRGTLY-----WGD VLNSEWELWKKTHDKQYNGQLDETKRRQIWEKNLKLITTHNIEYSQGKHTYDLAMNH--- -----LGDMTSEEVVQTMTGLRVP------SNR-QSNNT-YE-PDWTTRIPKYIDYRKKG YVTPVQNQGACGSCWAFSSVGALEGQLMKKTGDLVSLSPQNLVDCDAD--NYGCQGGYMT NAFGYVRDNNGIDSDAIYPYIG-----QDEG-CLYKPSG--KAAGCKGFKEIPIGDEKAL KRAVAQVGPVSVSIDASQPSFQFYNKGVYYDKNCDPEGINHAILAVGYGNL-KGTKHWIV KNSWGTQWGRKGFALLARDKKNACG----IANLASFPLM------ >XP_018088930.1 cathepsin K [Xenopus laevis] ------------------------------------------------------------ ---------------------------------MRWFSLLSFVLSLVKIGLC-----QDN SLDSKWELWKKTYHKQYNGQLDETRRRHIWEKNLNLISHHNKEFSQGMHTYDLAMNH--- -----LGDMTSEEVVQKMMGLKVP------PNH-RPNNT-YI-PDRTARVPEYIDYRKRG YVTPVQNQGVCGSCWAFSSVGALEGQLKKKTGNLVSLSPQNLVDCDTD--NYGCQGGYMT NAFGYVRDNGGIDSDAEYPYIG-----QDEG-CHYNPTE--KAATCKGYKEIPIGSEKAL KRAVAHVGPVSVSIDASLPSFQFYNKGVYYDESCNPEAVNHAVLVVGYGNE-KGIKHWII KNSWGDWWGKKGYVLLARDKKNACG----ITTLASFPVM------ >XP_015805372.1 PREDICTED: cathepsin K-like [Nothobranchius furzeri] ------------------------------------------------------------ ---------------------------------MLSLVC-VLLLAVSARGHL-----DEA LLDAQWEHWKMTHSKEYNGLDEEGIRRAIWEKNMRMVEAHNQEAALGMHSYELGMNH--- -----LGDMTSEEVMEKMTGLLVP------MNR-EQSFTMTL-NESVSKLPKSIDYRRKG MVSSVKNQGSCGSCWAFSSAGALEGQLAKKTGQLVDLSPQNLVDCVKE--NDGCGGGYMT NAFNYVKDNGGIDSEEAYPYVG-----EEQL-CRYNSSG--MAAQCKGYVEVPKGSEHAL AMALFKAGPVSVGIDATQPSFQLYRKGIYYDTNCNKEDINHAVLAVGFGVSPKGKKYWIV KNSWGEEWGNNGYILMARNRGNLCG----IANLASYPIM------ >XP_030250720.1 cathepsin K-like isoform X1 [Sparus aurata] ------------------------------------------------------------ -------------------------------M-MLQCVC-LLLLAASALGHL-----DET TLDHQWDEWKLTHRREYNGLGEEEIRRAIWEKNMRMIDAHNQEAALGMHSYELGMNH--- -----LGDMTSEEVSEKMTGLQIP------VNR-ERGFTMDL-DDNVTKLPKYIDYRKRG MVTPVKDQGSCGSCWAFSSAGALEGQLAKTTGTLRDLSPQNLVDCVSE--NQGCGGGYMT NAFKYVQDNGGIDSEEAYPYAG-----VDQP-CRYNSSG--MAAECRGYKEIPEGNEHAL AVALYKVGPVSVGIDATQSSFQFYSKGVYYDPNCNKDDINHAVLAVGYGVSVKGKKYWIV KNSWSENWGRQGYILMARNRGNLCG----IANLASYPIM------ >XP_004078392.1 cathepsin K [Oryzias latipes] ------------------------------------------------------------ ---------------------------------MWSCTCVLLLLSASVMSQM-----DET TLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQ--- -----FGDMTQEEVVERMTGLQMP------LNP-EPRVPMET-DGSLIKLPKSVDYRKKG MVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTE--NDGCGGGYMT NAFKYVQENGGIDSEAAYPYMG-----EDQP-CRYNVSG--LAAQIKGYKEVPEGDEHAL AVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIV KNSWGETWGNKGYVLMARNRGNVCG----IANLASYPVM------
BMGE Cleaned alignment of selected proteins >sp|P43235|CATK_HUMAN Cathepsin K OS=Homo sapiens OX=9606 GN=CTSK PE=1 SV=1 MWGLK-LLLPVVSILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >tr|F1Q8A0|F1Q8A0_DANRE Cathepsin K OS=Danio rerio OX=7955 GN=ctsk PE=1 SV=1 RFGGFLVVLWCGLSLDEAWESWKITHKREYNGLNEESIRRTIWEKNMLFIEAHNKEYELGIHTYDLGMNHFGDMTLEEVAEKVMGLQMPMYR-DPANTFVPDDRVGKLPKSIDYRKLGYVTSVKNQGSCGSCWAFSSVGALEGQLMKTKGQLVDLSPQNLVDCVTENDGCGGGYMTNAFRYVSNNQGIDSEESYPYVGCAYNTSGVAASCRGYKEIPQGNERALTAAVANVGPVSVGIDAMQSTFLYYKSGVYYDPNCNKEDVNHAVLAVGYGATRGKKYWIVKNSWGEEWGKKGYVLMARNRNNACGIANLASFPVM >NP_031828.2 cathepsin K preproprotein [Mus musculus] MWVFK-LLLPMVSMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFPKM >NP_113748.1 cathepsin K precursor [Rattus norvegicus] MWVFK-LLLPVVSTLDTQWELWKKTHGKQYNSKVDEISRRLIWEKNLKKISVHNLEASLGAHTYELAMNHLGDMTSEEVVQKMTGLRVPPSRSFSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVSENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPVSVSIDASLTSFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGNKYWIIKNSWGESWGNKGYVLLARNKNNACGITNLASFPKM >NP_990302.2 cathepsin K precursor [Gallus gallus] LHWLAALLLPMAAELDAQWDLWKRTYRKQYNGKEDETSRRLIWEKNLKYIDAHNAEHALGKHSFQLAMNHLGDMTSEEVVRTMTGLRVPRSRPRPNGTLYVPDWSSRAPAAVDWRRKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSNNNGCGGGYMTNAFEYVRLNRGIDSEDAYPYIGCMYSPTGKAAKCRGYREIPEGNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDTSCNPENINHAVLAVGYGAQKGTKHWIIKNSWGTEWGNKGYVLLARNMNNACGIANLASFPKM >NP_999467.1 cathepsin K precursor [Sus scrofa] MWGLKVLLLPVMSILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQKGKKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_001171151.1 cathepsin K [Pan troglodytes] MWGLK-LLLPVVSILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFEYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSRGVYFDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >NP_001029607.1 cathepsin K precursor [Bos taurus] MWGLT-LLLPVVSILDTQWELWKKTYRKQYNSKGDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_038546429.1 cathepsin K isoform X1 [Canis lupus familiaris] MWGLELLLLPMASILDTQWDLWKKTYRKQYNSKVDELSRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSHSRSNDTLYIPDWESRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >NP_001076110.1 cathepsin K precursor [Oryctolagus cuniculus] MWGLK-LLLPVVSILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGGYMTNAFQYVQRNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGESWGNKGYILMARNKNNACGIANLASFPKM >XP_009242974.1 cathepsin K [Pongo abelii] MWGLK-LLLPVVSILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_008968710.1 cathepsin K [Pan paniscus] MWGLK-LLLPVVSILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_019693361.1 cathepsin K [Felis catus] MWGLKLLLLPTATILDTQWELWKKTYGKQYNNKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSRSNDTLYIPDWESRAPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYSKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_004002514.1 cathepsin K [Ovis aries] MWGLTLLLLPVLSILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRTPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_018877383.1 cathepsin K [Gorilla gorilla gorilla] MWGLK-LLLPVVSILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_021135601.1 cathepsin K [Columba livia] MWWPAALLVP--AELDAQWRLWKKTYGKEYNGEADEAARRLIWEKNLKYINRHNLEHALGVHSFQLAMNHLGDMTSEEVVRTMTGLKVPRGHQRHNGTLYVFDWTQRAPAAVDWRRKGYVTPVKNQGQCGSCWAFSSVGALEGQ------XXXXXXXXXXXXXXXXXXXXXXXXXTNAFEYVRQNRGIDSEDAYPYIGCMYSPSGKAAKCRGYREIPPGNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGAQKGTKHWIIKNSWGEEWGNKGYVLLARNMNNACGVANLASFPKM >XP_005677713.1 PREDICTED: cathepsin K [Capra hircus] MWGLTLLLLPILSILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYIPDWEGRTPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_010722261.2 cathepsin K [Meleagris gallopavo] ------MGAAVGT----------------------------------------TMGAALGTAVAPFGAAELHPQTSEEVVRTMTGLRVPRSRPRPNGTLYIPDWTSRAPPAVDWRRKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRTGKLLSLSPQNLVDCVSNNNGCGGGYMTNAFEYVRQNRGIDSEDAYPYIGCMYSPTGKAAKCRGYREIPEGNEKALKRAVARIGPVSVGIDASLPSFQFYSRGVYYDTSCNAENINHAVLAVGYGAQKGTKHWILKNSWGTEWGNKGYVLLARNMNNACGIANLASFPKM >XP_019334544.1 PREDICTED: cathepsin K [Alligator mississippiensis] MWCVGALLLPTAAALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGLHTYELAMNHLGDMTSEEVVQKMMGLKVPLSRPRSNDTLYEPDWTEQVPDAVDWRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRMGKLLSLSPQNLVDCVTNNDGCGGGYMTNAFEYVHTNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGTQKGAKYWIVKNSWSEEWGNKGYVLMARNMDNACGIANLASFPKM >XP_020767848.1 cathepsin K [Odocoileus virginianus texanus] MWGLTLLLLPVVSILDTQWELWKKNYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRAPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_025050923.1 cathepsin K [Alligator sinensis] MWCVGALLLPTAAALDAQWELWKKTHRKQYNGKPDELSRRLVWEKNLRYIGTHNLEVSLGLHTYELAMNHLGDMTSEEVVQKMTGLKVPLSRPRSNDTLYEPDWTEQVPDAVDWRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKRRMGKLLSLSPQNLVDCVTNNDGCGGGYMTNAFEYVHTNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVGIDASLPSFQFYSRGVYYDESCNAENINHAVLAVGYGTQKGAKYWIVKNSWSEEWGNKGYVLMARNMDNACGIANLASFPKM >XP_030856413.1 cathepsin L1-like [Strongylocentrotus purpuratus] NLTFLMGLVACAADLDSRWLEWKIAHTKSYTNDMNELERRLVWEENVKMINMHNLDHSLHKKGFRLGMNEYGDMRLHEVRSTMNGYKS-SNVTKVQGSTFLTPSNIQVPDTVDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQTFKKTSKLVSLSEQNLVDCSRTNMGCEGGLMDQGFQYVIDNHGIDSEDCYPYDACHYKASCDSAEVTGFTDVTSGDEQALMEAVASVGPVSVAIDASHQSFQLYESGVYDEPECSSSELDHGVLVVGYGTDGGKDYWLVKNSWGETWGLSGYIKMSRNKSNQCGIATSASYPLV >XP_031558775.1 cathepsin L1-like [Actinia tenebrosa] ---LLVCVLSVAVQDETQWQAWKNFHGKKYTTDLEESSRKAIWKNNLRKITQHNSEG----HSYTLAMNHLGDLTQDEFRYFFTGMKSHSNYTQRTGSAFLAPSNIKLPDEVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQHFKKTGKLVSLSEQNLVDCSTSNHGCQGGLMDNAFRYIKANGGIDTEASYPYQACRYKSSDVGAXDTGFVDIPEGDENSLKTAAGTVGPISVAIDAGHMSFQFYHTGVYNNPSCSSTRLDHGVLVAGYGTYQGKDYWLVKNSWGARWGMEGYIMMSRNKNNQCGIATKASYPLV >XP_038045514.1 procathepsin L-like [Patiria miniata] RVAVFLMVVALGMDLDGEWELFKKVHNKRYSGFGEEANRRSIFESNVKLITMHNLEYDLGNHTYRLGMNFYGDMTGKEFTQVMNGYKTRANP-PKATMTFREPQNVQYPTTVDWRTKGYVTPVKNQEQCGSCWAFSATGSLEGQNFAKTKVLPDLSEQNLVDCSYVDDGCNGGLMDDAFKYVISNKGIDKESCYVYKACHYNASEITGHCTGFVDVPTGNETALMAAAATIGPISVAIDASHNSFQLYSEGVYNEPECSPTELDHGVLVVGYGVDQGKDYWLVKNSWGASWGMQGYIMMSRNKNNQCGIATSASYPLV >XP_039258216.1 procathepsin L-like [Styela clava] -----MILTVCFALFQSEWEAWKGEHGKSYSYE-EENKRQYIWEKNLKKVVDHNMEADNGIHTYRLGMNQFADMDEDEWRSLVLGHVTRANQMSYCNMTY-EMSDPRADDTVDWRTKGYVTPVKNQLQCGSCWAFSTTGSIEGQHFKKTGMLVSLSEQNLIDCSTPDHGCHGGLMDNAFKYIVMNGGVDTESSYPYMACKFNKMNIGATITGCVDIAHGDEMSLKSAVMRVGPISVAIDAGHSSFQLYKSGVYTSMECSSTKLDHGVLAVGYGTEMGKDYWLVKNSWGEMWGMEGYIMMARNSNNMCGIATQASYPTV >CAE1309900.1 CTSL [Sepia pharaonis] MKCFFFALLAVSTKLDKLWEDFKTQYWKNYESANTESLRRLIWEKNFNRVIVHNSHADNGLQTYWLGINEYADMLGYEFVRMMNGLLP-RNLTMHRPEFTVDDDVSKLPSEVDWRQQGYVTPVKNQGQCGSCWAFSTTGSLEGQHFKKTKNLISLSEQDLVDCSRDNLGCNGGLMDQAFTCIKKHKGIMLEEDYPYEGCRFDVSKVAATVRGYVDVKSGDEKALQKAVATVGPISVAIDASHFSFQLYSHGVYKEPSCSSTRLDHGVLVVGYGTKNGEAYWLVKNSWGKSWGMHGYIMMARNHNNMCGIATQASYPLV >XP_006557802.1 cathepsin L1 [Apis mellifera] -LFLIITIFTTAHLVNQEWMTFKMEHKKVYKSDVEERFRMKIFMDNKHKIAKHNSNYEMKKVSYKLKMNKYGDMLHHEFVNILNGFNKSRSERLPVGASFIEPANVVLPKKVDWRKEGAVTPVKDQGHCGSCWSFSATGALEGQHFRRTGVLVSLSEQNLIDCSGKNNGCNGGLMDQAFQYIKDNKGLDTEASYPYEACRYNPANSGAIDVGYIDIPTGDEKLLKAAVATIGPVSVAIDASHQSFQFYSEGVYYEPECSSEELDHGVLVIGYGTNNGQDYWLVKNSWGETWGNNGYIKMARNKLNHCGIASSASYPLV >NP_725347.1 cysteine proteinase-1, isoform A [Drosophila melanogaster] TAVLLLALLAVAQVVMEEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNGFNYTAADESFKGVTFISPAHVTLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEACHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDSGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV >NP_001256718.1 Cathepsin L-like [Caenorhabditis elegans] ---RFLALVAAVVSAIEKWDDYKEDFDKEYS-ESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRK-LNGYRRLGDSRIKNSSSFLAPFNVQVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDEHGDYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV >KAB0356916.1 hypothetical protein FD754_001072 [Muntiacus muntjak] MWGLTLLLLPVVSILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRAPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_043313580.1 cathepsin K [Cervus canadensis] MWGLTLLLLPVVSILDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKRISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPASRSRSNDTLYTPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPISVAIDASLTSFQFYRKGVYYDENCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM >XP_040189617.1 cathepsin K-like [Rana temporaria] MYWIYSIALPLVRVLNSEWELWKKTHDKQYNGQLDETKRRQIWEKNLKLITTHNIEYSQGKHTYDLAMNHLGDMTSEEVVQTMTGLRVPSNR-QSNNT-YEPDWTTRIPKYIDYRKKGYVTPVQNQGACGSCWAFSSVGALEGQLMKKTGDLVSLSPQNLVDCDADNYGCQGGYMTNAFGYVRDNNGIDSDAIYPYIGCLYKPSGKAAGCKGFKEIPIGDEKALKRAVAQVGPVSVSIDASQPSFQFYNKGVYYDKNCDPEGINHAILAVGYGNLKGTKHWIVKNSWGTQWGRKGFALLARDKKNACGIANLASFPLM >XP_018088930.1 cathepsin K [Xenopus laevis] MRWFSSFVLSLVKSLDSKWELWKKTYHKQYNGQLDETRRRHIWEKNLNLISHHNKEFSQGMHTYDLAMNHLGDMTSEEVVQKMMGLKVPPNH-RPNNT-YIPDRTARVPEYIDYRKRGYVTPVQNQGVCGSCWAFSSVGALEGQLKKKTGNLVSLSPQNLVDCDTDNYGCQGGYMTNAFGYVRDNGGIDSDAEYPYIGCHYNPTEKAATCKGYKEIPIGSEKALKRAVAHVGPVSVSIDASLPSFQFYNKGVYYDESCNPEAVNHAVLVVGYGNEKGIKHWIIKNSWGDWWGKKGYVLLARDKKNACGITTLASFPVM >XP_015805372.1 PREDICTED: cathepsin K-like [Nothobranchius furzeri] MLSLVVLLLAVSALLDAQWEHWKMTHSKEYNGLDEEGIRRAIWEKNMRMVEAHNQEAALGMHSYELGMNHLGDMTSEEVMEKMTGLLVPMNR-EQSFTMTLNESVSKLPKSIDYRRKGMVSSVKNQGSCGSCWAFSSAGALEGQLAKKTGQLVDLSPQNLVDCVKENDGCGGGYMTNAFNYVKDNGGIDSEEAYPYVGCRYNSSGMAAQCKGYVEVPKGSEHALAMALFKAGPVSVGIDATQPSFQLYRKGIYYDTNCNKEDINHAVLAVGFGVSKGKKYWIVKNSWGEEWGNNGYILMARNRGNLCGIANLASYPIM >XP_030250720.1 cathepsin K-like isoform X1 [Sparus aurata] MLQCVLLLLAASATLDHQWDEWKLTHRREYNGLGEEEIRRAIWEKNMRMIDAHNQEAALGMHSYELGMNHLGDMTSEEVSEKMTGLQIPVNR-ERGFTMDLDDNVTKLPKYIDYRKRGMVTPVKDQGSCGSCWAFSSAGALEGQLAKTTGTLRDLSPQNLVDCVSENQGCGGGYMTNAFKYVQDNGGIDSEEAYPYAGCRYNSSGMAAECRGYKEIPEGNEHALAVALYKVGPVSVGIDATQSSFQFYSKGVYYDPNCNKDDINHAVLAVGYGVSKGKKYWIVKNSWSENWGRQGYILMARNRGNLCGIANLASYPIM >XP_004078392.1 cathepsin K [Oryzias latipes] MWSCTLLLLSASVTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGLQMPLNP-EPRVPMETDGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTENDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNKGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYPVM
PhyML tree of selected proteins (XP_030250720_1_cathepsin_K_like_isoform_X1__Sparus_aurata_:0.13790124,XP_015805372_1_PREDICTED__cathepsin_K_like__Nothobranchius_furzeri_:0.11888803,(XP_004078392_1_cathepsin_K__Oryzias_latipes_:0.19659964,(tr_F1Q8A0_F1Q8A0_DANRE_Cathepsin_K_OS_Danio_rerio_OX_7955_GN_ctsk_PE_1_SV_1:0.28884903,(((((XP_021135601_1_cathepsin_K__Columba_livia_:0.07775423,(NP_990302_2_cathepsin_K_precursor__Gallus_gallus_:0.03168703,XP_010722261_2_cathepsin_K__Meleagris_gallopavo_:0.13407521):0.02829489):0.09729271,(XP_025050923_1_cathepsin_K__Alligator_sinensis_:0.00000001,XP_019334544_1_PREDICTED__cathepsin_K__Alligator_mississippiensis_:0.00342207):0.08822554):0.04070008,(XP_001171151_1_cathepsin_K__Pan_troglodytes_:0.00391182,(((NP_999467_1_cathepsin_K_precursor__Sus_scrofa_:0.007615,(NP_001076110_1_cathepsin_K_precursor__Oryctolagus_cuniculus_:0.00000001,(NP_113748_1_cathepsin_K_precursor__Rattus_norvegicus_:0.01511217,NP_031828_2_cathepsin_K_preproprotein__Mus_musculus_:0.03667985):0.10575384):0.02665603):0.00423676,(((NP_001029607_1_cathepsin_K_precursor__Bos_taurus_:0.00336674,(XP_004002514_1_cathepsin_K__Ovis_aries_:0.00000001,XP_005677713_1_PREDICTED__cathepsin_K__Capra_hircus_:0.00322896):0.00654829):0.00261916,(XP_020767848_1_cathepsin_K__Odocoileus_virginianus_texanus_:0.00323412,(XP_043313580_1_cathepsin_K__Cervus_canadensis_:0.00324611,KAB0356916_1_hypothetical_protein_FD754_001072__Muntiacus_muntjak_:0.00000001):0.0032365):0.0038581):0.01249488,(XP_019693361_1_cathepsin_K__Felis_catus_:0.01547148,XP_038546429_1_cathepsin_K_isoform_X1__Canis_lupus_familiaris_:0.01581647):0.00822584):0.00584259):0.02315337,((XP_008968710_1_cathepsin_K__Pan_paniscus_:0.00000001,(XP_009242974_1_cathepsin_K__Pongo_abelii_:0.00000001,XP_018877383_1_cathepsin_K__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001,sp_P43235_CATK_HUMAN_Cathepsin_K_OS_Homo_sapiens_OX_9606_GN_CTSK_PE_1_SV_1:0.00325597):0.00000001):0.00598997):0.1160448):0.08239406,(XP_018088930_1_cathepsin_K__Xenopus_laevis_:0.14366785,XP_040189617_1_cathepsin_K_like__Rana_temporaria_:0.17571968):0.22045923):0.19680781,((NP_001256718_1_Cathepsin_L_like__Caenorhabditis_elegans_:0.74579818,(NP_725347_1_cysteine_proteinase_1__isoform_A__Drosophila_melanogaster_:0.31577538,XP_006557802_1_cathepsin_L1__Apis_mellifera_:0.27438147):0.25440425):0.15511619,((XP_038045514_1_procathepsin_L_like__Patiria_miniata_:0.40778751,XP_030856413_1_cathepsin_L1_like__Strongylocentrotus_purpuratus_:0.39927327):0.12937924,(CAE1309900_1_CTSL__Sepia_pharaonis_:0.74150077,(XP_039258216_1_procathepsin_L_like__Styela_clava_:0.53382818,XP_031558775_1_cathepsin_L1_like__Actinia_tenebrosa_:0.31946921):0.08251455):0.04259067):0.06914399):0.66300182):0.15787022):0.10516519):0.03901891);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)