PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0099 | O75339 | Cartilage intermediate layer protein 1 | CILP | CILP-1, HsT18872 | Homo_sapiens | Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
Domains | Gene Ontology |
PF00090 (TSP_1) PF13330 (Mucin2_WxxW) |
GO:0005201 (enables) extracellular matrix structural constituent
GO:0010629 (involved in) negative regulation of gene expression GO:0043569 (involved in) negative regulation of insulin-like growth factor receptor signaling pathway GO:0060392 (involved in) negative regulation of SMAD protein signal transduction GO:0071560 (involved in) cellular response to transforming growth factor beta stimulus GO:0005615 (is active in) extracellular space GO:0062023 (is active in) collagen-containing extracellular matrix GO:0005576 (located in) extracellular region GO:0070062 (located in) extracellular exosome |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |