Click here to access PB0092 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0092 P05186 Alkaline phosphatase, tissue-nonspecific isozyme ALPL AP-TNAP, APTNAP, HOPS, HPPA, HPPC, HPPI, HPPO, TNALP, TNAP, TNSALP, alkaline phosphatase, biomineralization associated, tissue-nonspecific isozyme Homo_sapiens During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity).

DomainsGene Ontology
PF00245 (Alk_phosphatase)
GO:0003824 (enables) catalytic activity
GO:0004035 (enables) alkaline phosphatase activity
GO:0004427 (enables) inorganic diphosphatase activity
GO:0005509 (enables) calcium ion binding
GO:0005515 (enables) protein binding
GO:0016462 (enables) pyrophosphatase activity
GO:0016787 (enables) hydrolase activity
GO:0016791 (enables) phosphatase activity
GO:0016887 (enables) ATP hydrolysis activity
GO:0033883 (enables) pyridoxal phosphatase activity
GO:0043262 (enables) adenosine-diphosphatase activity
GO:0046872 (enables) metal ion binding
GO:0050187 (enables) phosphoamidase activity
GO:0052732 (enables) phosphoethanolamine phosphatase activity
GO:0001501 (involved in) skeletal system development
GO:0001649 (involved in) osteoblast differentiation
GO:0001958 (involved in) endochondral ossification
GO:0003006 (involved in) developmental process involved in reproduction
GO:0016311 (involved in) dephosphorylation
GO:0030282 (involved in) bone mineralization
GO:0031214 (involved in) biomineral tissue development
GO:0032496 (involved in) response to lipopolysaccharide
GO:0033280 (involved in) response to vitamin D
GO:0042822 (involved in) pyridoxal phosphate metabolic process
GO:0046677 (involved in) response to antibiotic
GO:0051384 (involved in) response to glucocorticoid
GO:0071407 (involved in) cellular response to organic cyclic compound
GO:0071529 (involved in) cementum mineralization
GO:0120162 (involved in) positive regulation of cold-induced thermogenesis
GO:0005576 (located in) extracellular region
GO:0005615 (located in) extracellular space
GO:0005739 (located in) mitochondrion
GO:0005758 (located in) mitochondrial intermembrane space
GO:0005886 (located in) plasma membrane
GO:0016020 (located in) membrane
GO:0031012 (located in) extracellular matrix
GO:0031225 (located in) anchored component of membrane
GO:0031966 (located in) mitochondrial membrane
GO:0065010 (located in) extracellular membrane-bounded organelle
GO:0070062 (located in) extracellular exosome

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)