PB0089

DATABASE

Click here to access PB0089 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0089	Q13103	Secreted phosphoprotein 2	spp2	SPP-24, SPP24	Homo_sapiens	Could coordinate an aspect of bone turnover.

Domains

Gene Ontology

PF07448 (Spp-24)

GO:0004866 (enables) endopeptidase inhibitor activity
GO:0001501 (involved in) skeletal system development
GO:0010951 (involved in) negative regulation of endopeptidase activity
GO:0046849 (involved in) bone remodeling
GO:0005576 (located in) extracellular region
GO:0005788 (located in) endoplasmic reticulum lumen
GO:0031089 (located in) platelet dense granule lumen
GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)
Selected proteins from model organisms

>sp|Q13103|SPP24_HUMAN Secreted phosphoprotein 24 OS=Homo sapiens OX=9606 GN=SPP2 PE=1 SV=1
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYL
FRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTV
KVSAQQVQGVHARCSWSSSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYD
RSLGIMRRVLPPGNRRYPNHRHRARINTDFE
>tr|E9QG22|E9QG22_DANRE Secreted phosphoprotein 2 OS=Danio rerio OX=7955 GN=spp2 PE=3 SV=1
MKMRCCVFLYLLLQVLGGLGLPLFELSSKADDALQMALNEINAHYTRIHLYRVSKASVKK
IVPLGMNTFDLHLKFGIRETECKKSSGLDPQGCMYRKGFFVAKAGCYMRARTTLQSTRII
ALRCTKADSLSSESSEEGALTSYIDLNHFWFTDRTHSTTSPSIHLGPPMHESHHANREDS
HVRGDHFNNHLPYH
>NP_083545.1 secreted phosphoprotein 24 precursor [Mus musculus]
MEQAMLKTLALLVLGMHYWCATGFPVYDYDPSSLQEALSASVAKVNSQSLSPYLFRATRSSLKRVNVLDE
DTLVMNLEFSVQETTCLRDSGDPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRWASSSESNSSEE
MMFGDMARSHRRRNDYLLGFLSDESRSEQFRDRSLEIMRRGQPPAHRRFLNLHRRARVNSGFE

>NP_446029.1 secreted phosphoprotein 24 precursor [Rattus norvegicus]
MELATMKTLVMLVLGMHYWCASGFPVYDYDPSSLQEALSASVAKVNSQSLSPYLFRATRSSLKRVNVLDE
DTLVMNLEFTVQETTCLRESGDPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRWASTSESNSSEE
MIFGDMARSHRRRNDYLLGFLYDEPKGEQFYDRSIEITRRGHPPAHRRFLNLQRRARVNSGFE

>NP_776613.2 secreted phosphoprotein 24 precursor [Bos taurus]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDE
DSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHWSSSSGSSSSE
EMFFGDILGSSTSRNSYLLGLTPDRSRGEPLYEPSREMRRNFPLGNRRYSNPWPRARVNPGFE

>NP_001376273.1 secreted phosphoprotein 24 isoform 1 [Gallus gallus]
MGKTTEDFERHTMRSLIFVLALSVFTCSGFPVYDYELPVTEEALNASIARINSQTWGPNLYGVVRSHVRH
VDMWNSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCHQSTFS
SESMSSEETMYMLMTDPRKRGSSRSEAFSSRGRGRSNGDWRKPDYTSPGKVE

>NP_998945.1 secreted phosphoprotein 24 precursor [Sus scrofa]
MEKRAMRMLAMFVLGTSFWSCAGFPVYDYDPSSLREAVGASVAKVNSQSLSPYLFRAFRSSLKRVNVLGE
DSLSMDIEFGIRETTCKRDSGEDPATCDFQRGYFTPSAICRSTVQISAEKVQDVWVRCRWSSSSESNSSE
EMIFGDILGSSTSRNNYLRGLIPDVSRTEPLYERSLETMRRFPPPGNRSFPNQWPRARTNTGFE

>NP_001009453.1 secreted phosphoprotein 24 precursor [Ovis aries]
MEKMVMKMLVIFVFGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDE
DSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAERVQDVWVRCHWSSSSGSSSSE
EMFFGDILGSSTSRNSHLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYSNPWPRARVNPGFE

>XP_005635937.1 secreted phosphoprotein 24 isoform X5 [Canis lupus familiaris]
MEKMVVKILIMFVLGAHFPSCAGFPVYDYDPSSLREALSASVAKVNSQSLSPYLFRAFRSSVKRVYVLDQ
DSVNMDLEFGIRETTCRRDSGEDPATCDFQRGYYSPAAVCRSTVRVVAEQVQDVWVRCQWSSSSESNSSE
EMFLGDVLGSSQWRNNYLLGLISEKPRSEQFRERSVENLRRILPPGNRGDPNRWHRLQE

>XP_017193021.1 PREDICTED: secreted phosphoprotein 24 [Oryctolagus cuniculus]
MLSGTERVVMRVLLAFALGADLWSCAGFPVYDYEPASLREALRASVAKVNSQSLSPYLLRAFGSSLRRVN
ALDEDTVIMNLEFSLRETTCRADSGGDPSTCAFQRGYYVPTLTCRSTVQMSAEQVQGVWARCHWSSMSDS
DSSEEMIFGDMVRAYTWRNEYPLGLTRDEPRSQRLYDPSLETVRRAFPPGNGRFPNYQRRARISPVFE

>XP_024099377.1 secreted phosphoprotein 24 [Pongo abelii]
MISRMEKMTTMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYLFRAFRSSLKR
VEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVPTAVCRSTVKVSAQQVQGVHARCSWSSST
SESYSSEEMIFGDMLGSHKWRHNYLFGLIPDESISEQFYDRSLEIMRRVLPPGNRRYPNHRHRARINTDF
E

>XP_010711534.1 secreted phosphoprotein 24 [Meleagris gallopavo]
MGKTREDFERHTMKSLIFVLTLSVFSCSGFPVYDYELPVTEEALNASIARINSQSWGPNLYGVVRSHVRH
VDMWNSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCHQSTFS
SESMSSEEMMHLLMTSPSKRGSSRSEAFSSRGRGRINGDWHKPDYASPGKIE

>XP_003813171.2 secreted phosphoprotein 24 [Pan paniscus]
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKR
VEVPDENNLVMNLEFSIRETTCRKDSGEDPTTCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSST
SESYSSSEEMIFGDMFRSHKWRNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTD
FE

>XP_003991321.2 secreted phosphoprotein 24 [Felis catus]
METKVPILLVLGVNFLSCAGFPVYDYDPSSLREALSASVAKVNAQSLSPYLFRAFRGSIKRVYVLDQDSL
SMDLEFGIRETTCRRESGEDPSTCDFQRGYYMPAVVCRSTVRMSAEQVRDVWVRCHWSSSSESNSSEEMG
FGDILGSSTWRNLYLPGLSPDKSRSERSERSLESLRRIFPPGNRGYPYKGHRTRTNAGFE

>XP_004033443.1 secreted phosphoprotein 24 [Gorilla gorilla gorilla]
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKR
VEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSST
SESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDF
E

>XP_005513175.1 secreted phosphoprotein 24 [Columba livia]
MRILIFVLTLSVFSCSGFPVYDYELPVTEEALNASIARINSQSWGTNLYGVVRSHVTRVDMWNSNAYKLE
LQFSIRETVCTKASGRDPFTCDFKIGPFVTTAFCRSVVDVSGELISNVIVQCHRGTFSSESMSSEEMMHI
PIMNPNRRGSSHREDDVFAPEAFPSSGRGGSRGGWHKPNYFRSDKIE

>XP_005678806.2 PREDICTED: secreted phosphoprotein 24 [Capra hircus]
MEKMVMKMLVIFVLGMNHWTCTGFPVYDYDPVSLKEALSASVAKVNSQSLSPYLFRGFRSSIKRVNALDE
DSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAICRSTVRMSSERVQNVWVRCHWSSSSGSSSSE
EMFFGDILGSSTSRNSHLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYSNPWPRARVNPGFE

>XP_006036702.1 secreted phosphoprotein 24 [Alligator sinensis]
MIFREQTMETLLIFAFVMSIFSCSGLPMYDYEPSIAENALNASIARLNSRLQGRNLFGVIRSYVRRVDLL
DDNSYNIMLDFNIQEITCSKDSERDPSTCDFKTGPYAQAAFCRSTVYVSEEQIQNLAVHCHQDSSSSESA
SSEEMWYLRMMDLNRRGNGRNEGK

>XP_014449740.1 PREDICTED: secreted phosphoprotein 24 [Alligator mississippiensis]
METLLIFAFVMSIFSCSGLPMYDYEPSIAENALNASIARLNSRLQGRNLFGVIRSYVRRVDLLDDNSYNI
ILDFNIQETTCSKDSERDPSTCDFKTGPYAQAAFCRSTVYVSEEQSQNLAVRCHQDSSSSESASSEEMWY
LRMMDLNRRGNGRNEAILAPEAFSSGRRGNPYKTWHKPRDINPYRFK

>XP_016806254.1 secreted phosphoprotein 24 [Pan troglodytes]
MISRMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKR
VEVLDENNLVMNLEFSIRETTCRKDSGEDPTTCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSWSSST
SESYSSSEEMIFGDMFRSHKWRNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTD
FE

>XP_020749511.1 secreted phosphoprotein 24 [Odocoileus virginianus texanus]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDQASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDD
DSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHWPSSSGSSSSE
EMFFGDILGSSTSRNSYLLGLTPDRSRDEPLYERSREMRRNFPLGNRRYSNPWSRARVNPGFE

>XP_030265281.1 secreted phosphoprotein 24 [Sparus aurata]
MKSYVILLALLQTLGCSGIPLYNSELESMANRGLGAALEQVNSVYAVSHLYRVTRGSVNRVIPMGLNTVD
LLMTFGIKETECLKASASDPQTCAFRPGFFVPSFSCVSRVRMLETSAQVVALRCGHDGSSSSSSSSEEIF
SRGRHQLTVPFANRAPAPSAPPGRSLHGQTVEVQPRGDTFSNFLV

>XP_040213491.1 secreted phosphoprotein 24 [Rana temporaria]
MCSVRYNNPTQSPVRMKMIQFGILLGIFPFCLGFPTLNARQEALSRALDASLDQLNSQSWGRNLLKLSHT
GVTKIKPLQQMRYQRDDEVFEVNLKFSVRETTCDKDTTIDPTKCEFSAEPYMETPCESQVMVSRKKALVV
KARCNLYTTSSSESHSSEEKFLTIPRSPHGRIRSNPERFPAQWDPFGKKNQMINPRWEEEDRTSDHFLLE
>XP_043317985.1 secreted phosphoprotein 24 [Cervus canadensis]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFR
IQETTCRKESEADPATCDFQRGYQVPIAVCRSTVRMSAERAQDVWVRCHWSSSSGSSSSEEMFFGDILGSSTSRNSYLLG
LTPDRSRGEPLYERSREMRRNFPLGNRRYSNPWSRARVSPGFE
>OWK04704.1 SPP2 [Cervus elaphus hippelaphus]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFR
IQETTCRKESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHWSSSSGSSSSEEMFLGDILGSSTSRNSYLLG
LTPDRSRGEPLYERSREMRRNFPLGNRRYLNPWSKARVSPGFE
>KAF4022039.1 hypothetical protein G4228_013588 [Cervus hanglu yarkandensis]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFR
IQETTCRKESEADPATCDFQRGYQVPIAVCRSTVRMSAERAQDVWVRCHWSSSSGSSSSEEMFFGDILGSSTSRNSYLLG
KLRPF
>KAB0388096.1 hypothetical protein FD755_003052 [Muntiacus reevesi]
MEKMAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFR
IQETTCRRESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHWSSSSGSSSSEEKTMSKSSRFNHEYDMRRKP
LYSRDSQEQEKPWPLWSL

Mafft alignment of selected proteins

>sp|Q13103|SPP24_HUMAN Secreted phosphoprotein 24 OS=Homo sapiens OX=9606 GN=SPP2 PE=1 SV=1
MIS-----RMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDP-SSLRDALSASVVKVNSQ
SLSPYLFRAFRSSLKRVEVL-------DENNLVMNLEFSIRETTCRKDSGEDPATCAFQR
DYYVSTAVCRSTVKVSAQQVQGVHARCS-WSSSTSESY-SSEEMIFGDMLG-----SHKW
RNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE
>tr|E9QG22|E9QG22_DANRE Secreted phosphoprotein 2 OS=Danio rerio OX=7955 GN=spp2 PE=3 SV=1
--------------MKMRCCVFLYLLLQVLGGLGLPLFELS--SKADDALQMALNEINAH
YTRIHLYRVSKASVKKIVPL-------GMNTFDLHLKFGIRETECKKSSGLDPQGCMYRK
GFFVAKAGCYMRARTTLQSTRIIALRCT-KAD-SLSSE-SSEEGALTSYIDLNHFWFTDR
THSTTSPSIHLGP----PMHESHHANREDSHVRGDHFNNHLPY-------H
>NP_083545.1 secreted phosphoprotein 24 precursor [Mus musculus]
---------MEQ--AMLKTLALLVLGMHYWCATGFPVYDYDP-SSLQEALSASVAKVNSQ
SLSPYLFRATRSSLKRVNVL-------DEDTLVMNLEFSVQETTCLRDSG-DPSTCAFQR
GYSVPTAACRSTVQMSKGQVKDVWAHCR-WAS-SSESN-SSEEMMFGDMAR-----SHRR
RNDYLLGFLSDESRSEQFRDRSLEIMRRGQPPAHRRFLNLHRRARVNSGFE
>NP_446029.1 secreted phosphoprotein 24 precursor [Rattus norvegicus]
---------MEL--ATMKTLVMLVLGMHYWCASGFPVYDYDP-SSLQEALSASVAKVNSQ
SLSPYLFRATRSSLKRVNVL-------DEDTLVMNLEFTVQETTCLRESG-DPSTCAFQR
GYSVPTAACRSTVQMSKGQVKDVWAHCR-WAS-TSESN-SSEEMIFGDMAR-----SHRR
RNDYLLGFLYDEPKGEQFYDRSIEITRRGHPPAHRRFLNLQRRARVNSGFE
>NP_776613.2 secreted phosphoprotein 24 precursor [Bos taurus]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSVKRVNAL-------DEDSLTMDLEFRIQETTCRRESEADPATCDFQR
GYHVPVAVCRSTVRMSAEQVQNVWVRCH-WSS-SSGSS-SSEEMFFGDILG-----SSTS
RNSYLLGLTPDRSRGEPLYEPSRE-MRRNFPLGNRRYSNPWPRARVNPGFE
>NP_001376273.1 secreted phosphoprotein 24 isoform 1 [Gallus gallus]
MGKTT--EDFER--HTMRSL-IFVLALSVFTCSGFPVYDYEL-PVTEEALNASIARINSQ
TWGPNLYGVVRSHVRHVDMW-------NSNDYRLELQLSIRETECTKASGRDPFTCGFKV
GPFVPTAVCKSVVEVSSEQIVNVIVRCH-QSTFSSESM-SSEETMYMLMTD-----PRKR
GSSRS---------------EAFSSRGRGRSNGDWRKPDYTSPGKV----E
>NP_998945.1 secreted phosphoprotein 24 precursor [Sus scrofa]
---------MEK--RAMRMLAMFVLGTSFWSCAGFPVYDYDP-SSLREAVGASVAKVNSQ
SLSPYLFRAFRSSLKRVNVL-------GEDSLSMDIEFGIRETTCKRDSGEDPATCDFQR
GYFTPSAICRSTVQISAEKVQDVWVRCR-WSS-SSESN-SSEEMIFGDILG-----SSTS
RNNYLRGLIPDVSRTEPLYERSLETMRRFPPPGNRSFPNQWPRARTNTGFE
>NP_001009453.1 secreted phosphoprotein 24 precursor [Ovis aries]
---------MEK--MVMKMLVIFVFGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRRESEADPATCDFQR
GYHVPVAVCRSTVRMSAERVQDVWVRCH-WSS-SSGSS-SSEEMFFGDILG-----SSTS
RNSHLLGLTPDRSRGEPLYERSRE-MRRNFPLGNRRYSNPWPRARVNPGFE
>XP_005635937.1 secreted phosphoprotein 24 isoform X5 [Canis lupus familiaris]
---------MEK--MVVKILIMFVLGAHFPSCAGFPVYDYDP-SSLREALSASVAKVNSQ
SLSPYLFRAFRSSVKRVYVL-------DQDSVNMDLEFGIRETTCRRDSGEDPATCDFQR
GYYSPAAVCRSTVRVVAEQVQDVWVRCQ-WSS-SSESN-SSEEMFLGDVLG-----SSQW
RNNYLLGLISEKPRSEQFRERSVENLRRILPPGNRGDPNRWHRLQ-----E
>XP_017193021.1 PREDICTED: secreted phosphoprotein 24 [Oryctolagus cuniculus]
MLS-----GTER--VVMRVLLAFALGADLWSCAGFPVYDYEP-ASLREALRASVAKVNSQ
SLSPYLLRAFGSSLRRVNAL-------DEDTVIMNLEFSLRETTCRADSGGDPSTCAFQR
GYYVPTLTCRSTVQMSAEQVQGVWARCH-WSS-MSDSD-SSEEMIFGDMVR-----AYTW
RNEYPLGLTRDEPRSQRLYDPSLETVRRAFPPGNGRFPNYQRRARISPVFE
>XP_024099377.1 secreted phosphoprotein 24 [Pongo abelii]
MIS-----RMEKMTTMMKILIMFALGMNYWSCSGFPVYDYDP-SSLRDALSASVVKVNSQ
SLSPYLFRAFRSSLKRVEVL-------DENNLVMNLEFSIRETTCRKDSGEDPATCAFQR
DYYVPTAVCRSTVKVSAQQVQGVHARCS-WSSSTSESY-SSEEMIFGDMLG-----SHKW
RHNYLFGLIPDESISEQFYDRSLEIMRRVLPPGNRRYPNHRHRARINTDFE
>XP_010711534.1 secreted phosphoprotein 24 [Meleagris gallopavo]
MGKTR--EDFER--HTMKSL-IFVLTLSVFSCSGFPVYDYEL-PVTEEALNASIARINSQ
SWGPNLYGVVRSHVRHVDMW-------NSNDYRLELQLSIRETECTKASGRDPFTCGFKV
GPFVPTAVCKSVVEVSSEQIVNVIVRCH-QSTFSSESM-SSEEMMHLLMTS-----PSKR
GSSRS---------------EAFSSRGRGRINGDWHKPDYASPGKI----E
>XP_003813171.2 secreted phosphoprotein 24 [Pan paniscus]
MIS-----RMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDP-SSLRDALSASVAKVNSQ
SLSPYLFRAFRSSLKRVEVP-------DENNLVMNLEFSIRETTCRKDSGEDPTTCAFQR
DYYVSTAVCRSTVKVSAQQVQGVHARCS-WSSSTSESYSSSEEMIFGDMFR-----SHKW
RNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE
>XP_003991321.2 secreted phosphoprotein 24 [Felis catus]
--------------METKVPILLVLGVNFLSCAGFPVYDYDP-SSLREALSASVAKVNAQ
SLSPYLFRAFRGSIKRVYVL-------DQDSLSMDLEFGIRETTCRRESGEDPSTCDFQR
GYYMPAVVCRSTVRMSAEQVRDVWVRCH-WSS-SSESN-SSEEMGFGDILG-----SSTW
RNLYLPGLSPDKSRSER-SERSLESLRRIFPPGNRGYPYKGHRTRTNAGFE
>XP_004033443.1 secreted phosphoprotein 24 [Gorilla gorilla gorilla]
MIS-----RMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDP-SSLRDALSASVAKVNSQ
SLSPYLFRAFRSSLKRVEVL-------DENNLVMNLEFSIRETTCRKDSGEDPATCAFQR
DYYVSTAVCRSTVKVSAQQVQGVHARCS-WSSSTSESY-SSEEMIFGDMLG-----SHKW
RNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE
>XP_005513175.1 secreted phosphoprotein 24 [Columba livia]
----------------MRIL-IFVLTLSVFSCSGFPVYDYEL-PVTEEALNASIARINSQ
SWGTNLYGVVRSHVTRVDMW-------NSNAYKLELQFSIRETVCTKASGRDPFTCDFKI
GPFVTTAFCRSVVDVSGELISNVIVQCH-RGTFSSESM-SSEEMMHIPIMN-----PNRR
GSSHREDDV--------FAPEAFPSSGRGGSRGGWHKPNYFRSDKI----E
>XP_005678806.2 PREDICTED: secreted phosphoprotein 24 [Capra hircus]
---------MEK--MVMKMLVIFVLGMNHWTCTGFPVYDYDP-VSLKEALSASVAKVNSQ
SLSPYLFRGFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRRESEADPATCDFQR
GYHVPVAICRSTVRMSSERVQNVWVRCH-WSS-SSGSS-SSEEMFFGDILG-----SSTS
RNSHLLGLTPDRSRGEPLYERSRE-MRRNFPLGNRRYSNPWPRARVNPGFE
>XP_006036702.1 secreted phosphoprotein 24 [Alligator sinensis]
MI-------FRE--QTMETLLIFAFVMSIFSCSGLPMYDYEP-SIAENALNASIARLNSR
LQGRNLFGVIRSYVRRVDLL-------DDNSYNIMLDFNIQEITCSKDSERDPSTCDFKT
GPYAQAAFCRSTVYVSEEQIQNLAVHCH-QDSSSSESA-SSEEMWYLRMMD-----LNRR
GNGRNEG-------------------------------------------K
>XP_014449740.1 PREDICTED: secreted phosphoprotein 24 [Alligator mississippiensis]
----------------METLLIFAFVMSIFSCSGLPMYDYEP-SIAENALNASIARLNSR
LQGRNLFGVIRSYVRRVDLL-------DDNSYNIILDFNIQETTCSKDSERDPSTCDFKT
GPYAQAAFCRSTVYVSEEQSQNLAVRCH-QDSSSSESA-SSEEMWYLRMMD-----LNRR
GNGRNEAI---------LAPEAFSSGRRGNPYKTWHKPRDINPYRF----K
>XP_016806254.1 secreted phosphoprotein 24 [Pan troglodytes]
MIS-----RMEKMTMMMKILIMFALGMNYWSCSGFPVYDYDP-SSLRDALSASVAKVNSQ
SLSPYLFRAFRSSLKRVEVL-------DENNLVMNLEFSIRETTCRKDSGEDPTTCAFQR
DYYVSTAVCRSTVKVSAQQVQGVHARCS-WSSSTSESYSSSEEMIFGDMFR-----SHKW
RNNYLFGLISDESISEQFYDRSLGIMRRVLPPGNRRYPNHRHRARINTDFE
>XP_020749511.1 secreted phosphoprotein 24 [Odocoileus virginianus texanus]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDQ-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSVKRVNAL-------DDDSLTMDLEFRIQETTCRRESEADPATCDFQR
GYHVPIAVCRSTVRMSAERAQDVWVRCH-WPS-SSGSS-SSEEMFFGDILG-----SSTS
RNSYLLGLTPDRSRDEPLYERSRE-MRRNFPLGNRRYSNPWSRARVNPGFE
>XP_030265281.1 secreted phosphoprotein 24 [Sparus aurata]
----------------MKSYVILLALLQTLGCSGIPLYNSELESMANRGLGAALEQVNSV
YAVSHLYRVTRGSVNRVIPM-------GLNTVDLLMTFGIKETECLKASASDPQTCAFRP
GFFVPSFSCVSRVRMLETSAQVVALRCG-HDGSSSSSS-SSEEI------------FSRG
RHQLTVPFANRAPAPSAPPGRSLHGQTVEVQPRGDTFSNFLV---------
>XP_040213491.1 secreted phosphoprotein 24 [Rana temporaria]
MCSVRYNNPTQS-PVRMKMIQFGILLGIFPFCLGFPTLNARQ-EALSRALDASLDQLNSQ
SWGRNLLKLSHTGVTKIKPLQQMRYQRDDEVFEVNLKFSVRETTCDKDTTIDPTKCEFSA
EPYMETP-CESQVMVSRKKALVVKARCNLYTTSSSESH-SSEEKFLT---------IPRS
PHGRIRSNPERFPAQWDPFGKKNQMINPRWEEEDRTSDHFLL--------E
>XP_043317985.1 secreted phosphoprotein 24 [Cervus canadensis]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRKESEADPATCDFQR
GYQVPIAVCRSTVRMSAERAQDVWVRCH-WSS-SSGSS-SSEEMFFGDILG-----SSTS
RNSYLLGLTPDRSRGEPLYERSRE-MRRNFPLGNRRYSNPWSRARVSPGFE
>OWK04704.1 SPP2 [Cervus elaphus hippelaphus]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRKESEADPATCDFQR
GYHVPIAVCRSTVRMSAERAQDVWVRCH-WSS-SSGSS-SSEEMFLGDILG-----SSTS
RNSYLLGLTPDRSRGEPLYERSRE-MRRNFPLGNRRYLNPWSKARVSPGFE
>KAF4022039.1 hypothetical protein G4228_013588 [Cervus hanglu yarkandensis]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRKESEADPATCDFQR
GYQVPIAVCRSTVRMSAERAQDVWVRCH-WSS-SSGSS-SSEEMFFGDILG-----SSTS
RNSYLLG------KLRPF---------------------------------
>KAB0388096.1 hypothetical protein FD755_003052 [Muntiacus reevesi]
---------MEK--MAMKMLVIFVLGMNHWTCTGFPVYDYDP-ASLKEALSASVAKVNSQ
SLSPYLFRAFRSSIKRVNAL-------DEDSLTMDLEFRIQETTCRRESEADPATCDFQR
GYHVPIAVCRSTVRMSAERAQDVWVRCH-WSS-SSGSS-SSEEKTM----------SKSS
RFNHEYDM-----RRKPLYSRDSQEQEKPWPLWSL----------------

BMGE Cleaned alignment of selected proteins

>sp|Q13103|SPP24_HUMAN Secreted phosphoprotein 24 OS=Homo sapiens OX=9606 GN=SPP2 PE=1 SV=1
MMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYDRSLGMRRVLPPGNRRYPNRARINTDFE
>tr|E9QG22|E9QG22_DANRE Secreted phosphoprotein 2 OS=Danio rerio OX=7955 GN=spp2 PE=3 SV=1
MKMRCCVFLYLLLQVLGGLGLPLFELS-SKADDALQMALNEINAHYTRIHLYRVSKASVKKIVPLGMNTFDLHLKFGIRETECKKSSGLDPQGCMYRKGFFVAKAGCYMRARTTLQSTRIIALRCTSLSSESSEEGALTSYIDFTDRTHSTTSPSIHLGP----PMHESHHNREDSHVRGDHFNNY-------H
>NP_083545.1 secreted phosphoprotein 24 precursor [Mus musculus]
AMLKTLALLVLGMHYWCATGFPVYDYDPSSLQEALSASVAKVNSQSLSPYLFRATRSSLKRVNVLDEDTLVMNLEFSVQETTCLRDSG-DPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRSSESNSSEEMMFGDMARSHRRRNDYLLGFLSDESRSEQFRDRSLEMRRGQPPAHRRFLNRARVNSGFE
>NP_446029.1 secreted phosphoprotein 24 precursor [Rattus norvegicus]
ATMKTLVMLVLGMHYWCASGFPVYDYDPSSLQEALSASVAKVNSQSLSPYLFRATRSSLKRVNVLDEDTLVMNLEFTVQETTCLRESG-DPSTCAFQRGYSVPTAACRSTVQMSKGQVKDVWAHCRTSESNSSEEMIFGDMARSHRRRNDYLLGFLYDEPKGEQFYDRSIETRRGHPPAHRRFLNRARVNSGFE
>NP_776613.2 secreted phosphoprotein 24 precursor [Bos taurus]
MAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAEQVQNVWVRCHSSGSSSSEEMFFGDILGSSTSRNSYLLGLTPDRSRGEPLYEPSREMRRNFPLGNRRYSNRARVNPGFE
>NP_001376273.1 secreted phosphoprotein 24 isoform 1 [Gallus gallus]
HTMRSL-IFVLALSVFTCSGFPVYDYELPVTEEALNASIARINSQTWGPNLYGVVRSHVRHVDMWNSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCHSSESMSSEETMYMLMTDPRKRGSSRS---------------EAFSRGRGRSNGDWRKPDPGKV----E
>NP_998945.1 secreted phosphoprotein 24 precursor [Sus scrofa]
RAMRMLAMFVLGTSFWSCAGFPVYDYDPSSLREAVGASVAKVNSQSLSPYLFRAFRSSLKRVNVLGEDSLSMDIEFGIRETTCKRDSGEDPATCDFQRGYFTPSAICRSTVQISAEKVQDVWVRCRSSESNSSEEMIFGDILGSSTSRNNYLRGLIPDVSRTEPLYERSLEMRRFPPPGNRSFPNRARTNTGFE
>NP_001009453.1 secreted phosphoprotein 24 precursor [Ovis aries]
MVMKMLVIFVFGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAVCRSTVRMSAERVQDVWVRCHSSGSSSSEEMFFGDILGSSTSRNSHLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYSNRARVNPGFE
>XP_005635937.1 secreted phosphoprotein 24 isoform X5 [Canis lupus familiaris]
MVVKILIMFVLGAHFPSCAGFPVYDYDPSSLREALSASVAKVNSQSLSPYLFRAFRSSVKRVYVLDQDSVNMDLEFGIRETTCRRDSGEDPATCDFQRGYYSPAAVCRSTVRVVAEQVQDVWVRCQSSESNSSEEMFLGDVLGSSQWRNNYLLGLISEKPRSEQFRERSVELRRILPPGNRGDPNRLQ-----E
>XP_017193021.1 PREDICTED: secreted phosphoprotein 24 [Oryctolagus cuniculus]
VVMRVLLAFALGADLWSCAGFPVYDYEPASLREALRASVAKVNSQSLSPYLLRAFGSSLRRVNALDEDTVIMNLEFSLRETTCRADSGGDPSTCAFQRGYYVPTLTCRSTVQMSAEQVQGVWARCHMSDSDSSEEMIFGDMVRAYTWRNEYPLGLTRDEPRSQRLYDPSLEVRRAFPPGNGRFPNRARISPVFE
>XP_024099377.1 secreted phosphoprotein 24 [Pongo abelii]
TMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVVKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVPTAVCRSTVKVSAQQVQGVHARCSTSESYSSEEMIFGDMLGSHKWRHNYLFGLIPDESISEQFYDRSLEMRRVLPPGNRRYPNRARINTDFE
>XP_010711534.1 secreted phosphoprotein 24 [Meleagris gallopavo]
HTMKSL-IFVLTLSVFSCSGFPVYDYELPVTEEALNASIARINSQSWGPNLYGVVRSHVRHVDMWNSNDYRLELQLSIRETECTKASGRDPFTCGFKVGPFVPTAVCKSVVEVSSEQIVNVIVRCHSSESMSSEEMMHLLMTSPSKRGSSRS---------------EAFSRGRGRINGDWHKPDPGKI----E
>XP_003813171.2 secreted phosphoprotein 24 [Pan paniscus]
MMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKRVEVPDENNLVMNLEFSIRETTCRKDSGEDPTTCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSTSESYSSEEMIFGDMFRSHKWRNNYLFGLISDESISEQFYDRSLGMRRVLPPGNRRYPNRARINTDFE
>XP_003991321.2 secreted phosphoprotein 24 [Felis catus]
METKVPILLVLGVNFLSCAGFPVYDYDPSSLREALSASVAKVNAQSLSPYLFRAFRGSIKRVYVLDQDSLSMDLEFGIRETTCRRESGEDPSTCDFQRGYYMPAVVCRSTVRMSAEQVRDVWVRCHSSESNSSEEMGFGDILGSSTWRNLYLPGLSPDKSRSER-SERSLELRRIFPPGNRGYPYRTRTNAGFE
>XP_004033443.1 secreted phosphoprotein 24 [Gorilla gorilla gorilla]
MMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPATCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSTSESYSSEEMIFGDMLGSHKWRNNYLFGLISDESISEQFYDRSLGMRRVLPPGNRRYPNRARINTDFE
>XP_005513175.1 secreted phosphoprotein 24 [Columba livia]
--MRIL-IFVLTLSVFSCSGFPVYDYELPVTEEALNASIARINSQSWGTNLYGVVRSHVTRVDMWNSNAYKLELQFSIRETVCTKASGRDPFTCDFKIGPFVTTAFCRSVVDVSGELISNVIVQCHSSESMSSEEMMHIPIMNPNRRGSSHREDDV--------FAPEAFPSGRGGSRGGWHKPNSDKI----E
>XP_005678806.2 PREDICTED: secreted phosphoprotein 24 [Capra hircus]
MVMKMLVIFVLGMNHWTCTGFPVYDYDPVSLKEALSASVAKVNSQSLSPYLFRGFRSSIKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPVAICRSTVRMSSERVQNVWVRCHSSGSSSSEEMFFGDILGSSTSRNSHLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYSNRARVNPGFE
>XP_006036702.1 secreted phosphoprotein 24 [Alligator sinensis]
QTMETLLIFAFVMSIFSCSGLPMYDYEPSIAENALNASIARLNSRLQGRNLFGVIRSYVRRVDLLDDNSYNIMLDFNIQEITCSKDSERDPSTCDFKTGPYAQAAFCRSTVYVSEEQIQNLAVHCHSSESASSEEMWYLRMMDLNRRGNGRNEG---------------------------------------K
>XP_014449740.1 PREDICTED: secreted phosphoprotein 24 [Alligator mississippiensis]
--METLLIFAFVMSIFSCSGLPMYDYEPSIAENALNASIARLNSRLQGRNLFGVIRSYVRRVDLLDDNSYNIILDFNIQETTCSKDSERDPSTCDFKTGPYAQAAFCRSTVYVSEEQSQNLAVRCHSSESASSEEMWYLRMMDLNRRGNGRNEAI---------LAPEAFSGRRGNPYKTWHKPRPYRF----K
>XP_016806254.1 secreted phosphoprotein 24 [Pan troglodytes]
MMMKILIMFALGMNYWSCSGFPVYDYDPSSLRDALSASVAKVNSQSLSPYLFRAFRSSLKRVEVLDENNLVMNLEFSIRETTCRKDSGEDPTTCAFQRDYYVSTAVCRSTVKVSAQQVQGVHARCSTSESYSSEEMIFGDMFRSHKWRNNYLFGLISDESISEQFYDRSLGMRRVLPPGNRRYPNRARINTDFE
>XP_020749511.1 secreted phosphoprotein 24 [Odocoileus virginianus texanus]
MAMKMLVIFVLGMNHWTCTGFPVYDYDQASLKEALSASVAKVNSQSLSPYLFRAFRSSVKRVNALDDDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHSSGSSSSEEMFFGDILGSSTSRNSYLLGLTPDRSRDEPLYERSREMRRNFPLGNRRYSNRARVNPGFE
>XP_030265281.1 secreted phosphoprotein 24 [Sparus aurata]
--MKSYVILLALLQTLGCSGIPLYNSELSMANRGLGAALEQVNSVYAVSHLYRVTRGSVNRVIPMGLNTVDLLMTFGIKETECLKASASDPQTCAFRPGFFVPSFSCVSRVRMLETSAQVVALRCGSSSSSSSEEI-------FSRGRHQLTVPFANRAPAPSAPPGRSLHQTVEVQPRGDTFSN---------
>XP_040213491.1 secreted phosphoprotein 24 [Rana temporaria]
VRMKMIQFGILLGIFPFCLGFPTLNARQEALSRALDASLDQLNSQSWGRNLLKLSHTGVTKIKPLDDEVFEVNLKFSVRETTCDKDTTIDPTKCEFSAEPYMETP-CESQVMVSRKKALVVKARCNSSESHSSEEKFLT----IPRSPHGRIRSNPERFPAQWDPFGKKNQINPRWEEEDRTSDH--------E
>XP_043317985.1 secreted phosphoprotein 24 [Cervus canadensis]
MAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFRIQETTCRKESEADPATCDFQRGYQVPIAVCRSTVRMSAERAQDVWVRCHSSGSSSSEEMFFGDILGSSTSRNSYLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYSNRARVSPGFE
>OWK04704.1 SPP2 [Cervus elaphus hippelaphus]
MAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFRIQETTCRKESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHSSGSSSSEEMFLGDILGSSTSRNSYLLGLTPDRSRGEPLYERSREMRRNFPLGNRRYLNKARVSPGFE
>KAF4022039.1 hypothetical protein G4228_013588 [Cervus hanglu yarkandensis]
MAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFRIQETTCRKESEADPATCDFQRGYQVPIAVCRSTVRMSAERAQDVWVRCHSSGSSSSEEMFFGDILGSSTSRNSYLLG------KLRPF-----------------------------
>KAB0388096.1 hypothetical protein FD755_003052 [Muntiacus reevesi]
MAMKMLVIFVLGMNHWTCTGFPVYDYDPASLKEALSASVAKVNSQSLSPYLFRAFRSSIKRVNALDEDSLTMDLEFRIQETTCRRESEADPATCDFQRGYHVPIAVCRSTVRMSAERAQDVWVRCHSSGSSSSEEKTM-----SKSSRFNHEYDM-----RRKPLYSRDSQQEKPWPLWSL-------------

PhyML tree of selected proteins

(XP_030265281_1_secreted_phosphoprotein_24__Sparus_aurata_:0.53694477,tr_E9QG22_E9QG22_DANRE_Secreted_phosphoprotein_2_OS_Danio_rerio_OX_7955_GN_spp2_PE_3_SV_1:0.89434158,(XP_040213491_1_secreted_phosphoprotein_24__Rana_temporaria_:1.63859858,(((XP_006036702_1_secreted_phosphoprotein_24__Alligator_sinensis_:0.01787777,XP_014449740_1_PREDICTED__secreted_phosphoprotein_24__Alligator_mississippiensis_:0.0198844):0.38533055,(XP_005513175_1_secreted_phosphoprotein_24__Columba_livia_:0.14758725,(XP_010711534_1_secreted_phosphoprotein_24__Meleagris_gallopavo_:0.01659621,NP_001376273_1_secreted_phosphoprotein_24_isoform_1__Gallus_gallus_:0.06039649):0.13975714):0.30829314):0.51925355,(NP_998945_1_secreted_phosphoprotein_24_precursor__Sus_scrofa_:0.17606989,((NP_776613_2_secreted_phosphoprotein_24_precursor__Bos_taurus_:0.01480879,(((KAB0388096_1_hypothetical_protein_FD755_003052__Muntiacus_reevesi_:0.19702381,XP_020749511_1_secreted_phosphoprotein_24__Odocoileus_virginianus_texanus_:0.02096567):0.00000001,(OWK04704_1_SPP2__Cervus_elaphus_hippelaphus_:0.01594336,(KAF4022039_1_hypothetical_protein_G4228_013588__Cervus_hanglu_yarkandensis_:0.02896411,XP_043317985_1_secreted_phosphoprotein_24__Cervus_canadensis_:0.00000001):0.00522457):0.01055095):0.01052694,(NP_001009453_1_secreted_phosphoprotein_24_precursor__Ovis_aries_:0.0052608,XP_005678806_2_PREDICTED__secreted_phosphoprotein_24__Capra_hircus_:0.02607221):0.0106076):0.00611432):0.16659888,(((XP_024099377_1_secreted_phosphoprotein_24__Pongo_abelii_:0.01094627,(sp_Q13103_SPP24_HUMAN_Secreted_phosphoprotein_24_OS_Homo_sapiens_OX_9606_GN_SPP2_PE_1_SV_1:0.00000001,(XP_004033443_1_secreted_phosphoprotein_24__Gorilla_gorilla_gorilla_:0.00000001,(XP_016806254_1_secreted_phosphoprotein_24__Pan_troglodytes_:0.00000001,XP_003813171_2_secreted_phosphoprotein_24__Pan_paniscus_:0.00501738):0.01525287):0.00503002):0.01482159):0.12642364,(XP_017193021_1_PREDICTED__secreted_phosphoprotein_24__Oryctolagus_cuniculus_:0.31612011,(NP_083545_1_secreted_phosphoprotein_24_precursor__Mus_musculus_:0.04238503,NP_446029_1_secreted_phosphoprotein_24_precursor__Rattus_norvegicus_:0.05090015):0.21377056):0.0311845):0.10751926,(XP_005635937_1_secreted_phosphoprotein_24_isoform_X5__Canis_lupus_familiaris_:0.15584147,XP_003991321_2_secreted_phosphoprotein_24__Felis_catus_:0.15004424):0.05647839):0.02428126):0.00000003):0.47166006):0.47997652):1.01027979);

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)