PB0085

DATABASE

Click here to access PB0085 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0085	Q9UGM5	Fetuin-B	FETUB	16G2, Gugu, IRL685	Homo_sapiens	Protease inhibitor required for egg fertilization. Required to prevent premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.

Domains

Gene Ontology

PF00031 (2_Cystatin)

GO:0003674 (enables) molecular_function GO:0004857 (enables) enzyme inhibitor activity GO:0004866 (enables) endopeptidase inhibitor activity GO:0004869 (enables) cysteine-type endopeptidase inhibitor activity GO:0005515 (enables) protein binding GO:0008191 (enables) metalloendopeptidase inhibitor activity GO:0030414 (enables) peptidase inhibitor activity GO:0007338 (involved in) single fertilization GO:0007339 (involved in) binding of sperm to zona pellucida GO:0008150 (involved in) biological_process GO:0010466 (involved in) negative regulation of peptidase activity GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q9UGM5|FETUB_HUMAN Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2 MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGY VLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAI FYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNN ENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGS LTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGP RGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPK EKARTAECPGPAQNASPLVLPP >tr|E7FE90|E7FE90_DANRE Fetuin B OS=Danio rerio OX=7955 GN=fetub PE=1 SV=1 MMKQCVVLVILLGFFGVHGAPVENLTPGSCQDAVTNGAAAEALNKINLDRKEGYVLGLDR LSNAFYMKHGETGIVFYLTLDVLETKCHVLSKKPWKSCEIRSPEEYPVYGQCKAVMYMNR VHRVARLYKYSCTVRPVPASKIQERCPDCPMQLSGDNEEVLKTVKMGMEKYNNESGLNNY FAPLNITRASASLHLGRFYTAEFTIQETVCSSKTKDVDVSKCELMACEFAHKGLCKASHS VTVTKEEHLNIQCEIFEPEAAEEEKKKHLLGGEVDHSHTTGSSTAHDHTKTHTHEHSHEH THEHDHTKPHSHDHDHDHTKPHTHNHTHSHEHDHGHTHSHDHDHEHTHHAKAHEHGQDEW EHQHHQYGHKKDETHEHDHEIVLDHDHKHRHIHEHEHHHHHHHDKSHQTKSRRPDGIFNV LPPVDKPMILPSFPDKPAAGPEQPSTLPLLPDPEIPGQKEPTIHTFPSKTSPECPAQSTI ENGLLKQIVSEDPLFKPAA
Selected proteins from model organisms >sp|Q9UGM5|FETUB_HUMAN Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2 MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGY VLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIFFESVYGQCKAI FYMNNPSRVLYLAAYNCTLRPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNN ENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQASSCSLQSSDSVPVGLCKGS LTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPKVEESQQKNTPPTDSPSKAGP RGSVQYLPDLDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPMEEKLVVLPFPK EKARTAECPGPAQNASPLVLPP >tr|E7FE90|E7FE90_DANRE Fetuin B OS=Danio rerio OX=7955 GN=fetub PE=1 SV=1 MMKQCVVLVILLGFFGVHGAPVENLTPGSCQDAVTNGAAAEALNKINLDRKEGYVLGLDR LSNAFYMKHGETGIVFYLTLDVLETKCHVLSKKPWKSCEIRSPEEYPVYGQCKAVMYMNR VHRVARLYKYSCTVRPVPASKIQERCPDCPMQLSGDNEEVLKTVKMGMEKYNNESGLNNY FAPLNITRASASLHLGRFYTAEFTIQETVCSSKTKDVDVSKCELMACEFAHKGLCKASHS VTVTKEEHLNIQCEIFEPEAAEEEKKKHLLGGEVDHSHTTGSSTAHDHTKTHTHEHSHEH THEHDHTKPHSHDHDHDHTKPHTHNHTHSHEHDHGHTHSHDHDHEHTHHAKAHEHGQDEW EHQHHQYGHKKDETHEHDHEIVLDHDHKHRHIHEHEHHHHHHHDKSHQTKSRRPDGIFNV LPPVDKPMILPSFPDKPAAGPEQPSTLPLLPDPEIPGQKEPTIHTFPSKTSPECPAQSTI ENGLLKQIVSEDPLFKPAA >NP_067539.1 fetuin-B isoform 1 precursor [Mus musculus] MGLLRLLVLCTLAACCMARSPPAPPLPQRPLSPLHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRV HDVREHYQEDMGSLFYLTLDVLETDCHVLSRKAQKDCKPRMFYESVYGQCKAMFHINKPRRVLYLPAYNC TLRPVSKRKTHTTCPDCPSPIDLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEY LIKEAPCTKSQASCSLQHSDSEPVGICQGSTVQSSLRHVPLIQPVEKSVTVTCEFFESQAQVPGDENPAV TQGPQKLPQKNTAPTSSPSVTAPRGSIQHLPELDDEKPEESKGGSPEEAFPVQLDLTTNPQGDTLDVSFL YLEPGDKKLVVLPFPGKEQRSAECPGPEKENNPLVLPP >NP_001296451.1 fetuin-B isoform 1 precursor [Rattus norvegicus] MISRFHRCGSVTSSGMGVLRLLVLCTLAACCVARSPPAPPLPNAPFAPLRPLGCNDSEVLAVAGFALQNI NRVQKDGYMLTLNRVHDARVHRQEDMGSLFYLMLDVLETGCHVLSRKALKDCGPRIFYETVHGQCKAMFH VNKPRRVLYLPAYNCTLRPVSKRKIHSMCPDCPHPVDLSAPSVLEAATESLAKFNSENPSKQYALVKVTK ATTQWVVGPSYFVEYLIKESPCTQSQDSCSLQASDSEPVGLCQGSLIKSPGVPPQRFKKTVTVSCEFFES QDQVPGGENPADTQDAKKLPQKNTAPTSSPSITAPRGSIQHLPEQEEPEDSKGKSPEEPFPVQLDLTTNP QGDTLDVSFLYLEPEEKKLVVLPFPGKEQRSPECPGPEKQRTP >NP_001264337.1 fetuin-B precursor [Gallus gallus] MLLLISVLFGTQALCSWAASPPARELPSVLLSPTCHDAAVEEAADLALRQINADRTEGYILSLYRIFSVR EHPQEITGSVFYLILDVVDTECHVLSKQLWKNCTVRPAHTTVYGQCKAIIYINQSRKIAHLNTYECNLQP VPPRYIWGVCPDCPVDDCPTEPRYLETAVKSLAKFNEESEQTHYFSVLNVTRGSMQWVIGPAHFVEFLIQ ETSCSKRDPVADISKCKPLSPELAKIGFCKGSVVNSDMEHKQSVTISCEIYSSQDPVTGEGKLQTNQRPE ESSQNHQQAFSLHLGKTTGCVKILPPSTEDISFHKLRESQNEHEDIKSVSAKAIECTSTPPAPDGETTHV DEPGLTKPVTGPVILPFPAELSLSDSCPGEAKQTDSILHPLLTRQRAEV >XP_001153966.1 fetuin-B [Pan troglodytes] MGLLLPLALCILVLCCRAMSPPQLALNPSALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDA QEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLR PVSKKKIYMTCPDCPSSIPTDSSNRQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYL IKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPINLPK VEESQQKNTPPTDSPSKAGPRGNVQYLPDLDDKNSQEKGPQEAFPVHLDLTMNPQGETLDISFLFLEPME EKLVVLPFPKEKARTAECPGPAQNASPLILPP >XP_535835.2 fetuin-B [Canis lupus familiaris] MDLLLSLVLCTLAACCWATSVPMPVLPLPVLSRDCNNSGILEVAGFALQDINRDRKDGYVLSLNRVSDVR EHRQVAMGSLFYLTLDVLETDCHVLSRKPWKDCGVRHLHESVYGQCKALFYVNKPGRVLYLPAYNCTLRP VSRRRIHNRCPDCPSPRATDLSDPTVLEAALESLAKYNSESTSKQYSLVQVTRASSQWVYGPAYFVEYLI KESPCTKSQVSSCALQPPDSEPVGICKGSLGQRELEKFVSVTCHFFEPQVPAPGEENASASQGPVDLPGV GEFQQKNTAPTNSPSKAVPKGSVQYLPDLDDEKKPEGAQENSPVEAFPVKLDLTTDPQGESLDVSFLFLG PMERKLVVLPFPNKEQRSAECPGPAQQGNLLILPP >NP_001029390.1 fetuin-B precursor [Bos taurus] MNVLLLLVLCTLAMGCGATSPPQPAARPSSLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDA REHRQEAGLGSLFYFTLDVLETGCHVLSRTSWKNCEVRIFHESVYGQCKAIFYINKEKRIFYLPAYNCTL RPVSQSAIIMTCPDCPSTSPYDLSNPRFMETATESLAKYNSESPSKQYSLVKITKTSSQWVFGPAYFVEY LIKESPCVKSEGSSCALESPGSVPVGICHGSLGEPQGNQGKIISVTCSFFNSQAPTPRGENATVNQRPAN PSKTEELQQQNTAPTNSPTKAVPKGSVQYLPDWDKKREGSQEKDPVETFPVQLDLTTNPQGESLDVSFLF QEPMEEKVVVLPFPSKEQRSAECPGPAQKGYPFILPS >XP_008264796.1 PREDICTED: fetuin-B [Oryctolagus cuniculus] MGQPGSQNHSSLTLRRSTSQSVSAAPHPCFPLGMGLLQILGLCALAACCGVVSVPQPFLKDTPLLSRNCN DSDVLSVSGFALQDINRDQKDGYVLSLNRVSRVWEHTQDHLGSVFYLVLDVLQTGCHVLSKKAWQDCAVR TLHTSVYGQCKALFYINKPRRILYSIAYNCTLRPVSRRKIHSKCPDCPSPSRIDKSDPRVLEAAVESLAK FNRESTSKQYSLVKVTKATSQWMGSLAYFVEYLIQESPCTKSQAGSCSLQPSDSPVGLCKGTLIQNPLEK RVTVTCDFFEQQAPAPGTESLAGDQGPSNLPNVEELQQKITPPTDTPSKVLSTGIVQHLPDLDDEKPEGS QGEGPPEAFPVQLELTTNPQGELLDVSFLFLEPIEVKLVILPFPKEDQHSGQCPGPAQNFDPLILPP >XP_002832807.1 fetuin-B isoform X1 [Pongo abelii] MGLLLPLALCTLVLCCGAMSLPQLALNPSALLSRGCDDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDA QEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLR PVSKKKIYMTCPDCPSSIPTDSSSRQVLEAATDSLAKYNNENTFKQYSLFKVTRASSQWVVGPSYFVEYL IKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPTNLPK VEESQQKNTPPTDSPSKAGPRGSVQYLPDLDDKNSQEKGSQEAFPVHLDLTTNPQGETLDLSFLFLEPME EKLVVLPFPKEKARTAECPGPAQNASPLVLPP >XP_003132625.1 fetuin-B [Sus scrofa] MGLLLPLVLCALAVGCGATSPPQPLPPTSSLLLSHACNSSYVLDVVNLVLQEINRNQKDGYVLSPNRVSD VREHRQGDLGSLFYLTLDVIESSCHVLSKMSWKDCGLTPFHESEYGQCKAIFYINKARRIHYLPAYNCIL RPVSPGQLVTLCPDCPTHVNMSDTKVLEAATKSLEEFNKRRTSKKYSLVKVTRALFQWVFGPAYFVEYLI KESPCTKSQASSCALQPPNPEPVGICSGSRSERGPEKFVSVRCSFFKSQAPTPGDAYSTASRGDPTKVEE PQQESTASAKPVPKGSVQHLPGLGDKPKGSPETGPEEAFPVRVDLTSNPQGEPLDVSFLFPEPVEKDLVV LPFPSREWRSAECPGPARVSNPLVLPP >XP_003209226.1 fetuin-B [Meleagris gallopavo] MLLFISVLLGTQALCSWAASPPARELPSVLLSPSCHDAAVEEAADLALRQINADRTEGYILSLYRILSVR EHPQEITGSVFYLILDVVDTECHVLSKQLWKNCRVRPAHTTVYGQCKAIIYINQPRKIAHLNTYECNLQP VPPRYIWEVCPDCPVDDCPTEPKYLETAVKSLAKFNEESEQTHYFSVLNVTRASMQWVIGPAHFVEFVIQ ETSCPKREPAADVSKCKPLSPELAQMGFCKGSVVNSDMEQKETITISCEIYSPQDPVTEEGKLQTNQGSE ESSQNHQQAFPAETNPFSLHLGKTMGCVKILPPSTEDISFHKLRESQNEQEDRKPVPPRAIECVSTPPAP DGETTHIDKPVTGPVILPFPAEVSLSDSCPGEAKQIDSILHPLLTGKPAKV >XP_034813758.1 fetuin-B isoform X1 [Pan paniscus] MGLLLPLALCIQVLCCRAMSPPQLALNPSALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDA QEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLR PVSKKKIYMMCPDCPSSIPTDSSNRQVLEAATESLAKYNENTSKQYSLFKVTRASSQWVVGPSYFVEYLI KESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFESQAPATGSENSAVNQKPINLPKV EESQQKNTPPTDSPSKAGPRGNVQYLPDLDDKNSQEKGPQEAFPVHLDLTMNPQGETLDISFLFLEPMEE KLVVLPFPKEKARTAECPGPAQNASPLILPP >XP_019695567.1 fetuin-B isoform X2 [Felis catus] MGLLLPVVLCALAACCGATSPPLRFWPPIAHGCNDSGILELAGFALQDINRDRKDGYVLSLNRVSDVREH RQVNSLGSLFYFTLDVLETDCHVLSRKAWKDCGVRTLHKSVYGQCKALFYVNRPGRVLYVLAYNCTLRPV SRRSIHMMCPDCPSPFKLSNPKVLETAAESLAKYNKESASKQYSLFQVTRASGQWVFGFAFFVEYLIKES PCTKHQASSCALQPPDSVPVGLCKGTLTERQLQKFVSVTCDFFEPQAPAPGGENPAANQGPADLPTVEES QQKIIAPTNSPSKAVPKGSVQYLPDLDDEKPEDAQENSPLEAFPVQLELTTDPLGESLDVSFLFLDPEEK KVVVLPFPKKEQRSAECPGPAQQANPLVLPP >XP_004003110.1 fetuin-B [Ovis aries] MSVLLLLVLCTLAMGCGAASPPQPAARPSPLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDA REHRQEAGLGSLFYFTLDVLETGCHVLSRTSWKNCGVRIFHESVYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRAIIMMCPDCPSTSPYDLSNPRYMETATESLAKYNSRSPSKQYSVVKITKTFSQWVFGPAYFVEY LIKESPCTKSQGSSCALESPDSVPVGICHGSLSQSQGNPGKTISVTCSFFNSQAPTPRGENAAVNQRPAN PSKAEEPQQQNTASTNSPAKAVLKGSVQYLPDWDKKSEGSQEKDPVETFPVQLDLTTNPQGEPLDVSFLF LEPMEVKLVVLPFPSKEKRSAECPGPAQKDNPLILPP >XP_004038216.1 fetuin-B [Gorilla gorilla gorilla] MGLLLPLALCILVLCCGAMSPPQLALNPSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDA QEYRQDGLGSLFYLALDVLETDCHVLSKKAGQDCGMRIFFESVYGQCKAIFYMNNPSRVLYLAAYNCTLR PVSKKKIYMTCPDCPSSIPTDSSNRQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYL IKESPCTKSQASSCSLQSSDSVPVGLCKGSLTRTHWEKFVSVTCDFFELQAPATGSENSAVNQKPTNLPK VEESQQKNTPPTDSPSKAGPRGSVQYLPELDDKNSQEKGPQEAFPVHLDLTTNPQGETLDISFLFLEPME EKLVVLPFPKEKARTAECPGPAQNASPLVLPP >XP_005506654.1 fetuin-B [Columba livia] MVSLVLLLFGTQALCSWAAAHASEARAAFLSSPCNTTAAEEAADLALRQINADRREGYVLRLYRIFSVQE HPQEISSSAFYLVLDVVDTECHVLSKKLWKNCKARPAHGTVYGQCKAIIYINQARNIAHLNNYECILQPV PPRYIWSVCPDCPVDDGPTEPKYLEAAVQSLAKFNEESEQAHYFSVLNVTRASMQWVIGPAYFVEFLIQE TSCSKNDTIADISKCKPLSSELAQIGFCKGSVENSDLEHEQFVTISCEIYNLQDPATEEGKQQAKQTPGK SSQSHQQAFPSETNPFSPYLEKTVGLVKILPASTEDTYFQRLPESQTKRKDGKPVLPEAVRSTSTLDGQK TQVDKSDLTNPVTGPVILPFPEELSLSDSCPGEAKEVNSILQPLLPKKYTKV >XP_005675217.2 PREDICTED: fetuin-B [Capra hircus] MSVLLLLVLCTLAMGCGAASPPQPASRPSPLLSLDCNSSYVLDIANDILQDINRDRKDGYMLSLNRVSDA REHRQEAGLGSLFYFTLDVLETGCHVLSRTSWKNCGVRIFHESVYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRSAIIMMCPDCPSTSPYDLSNPRYMETATESLAKYNSRSPSKQYSVVKITKTFSQWVFGPAYFVEY LIKESPCTKSQGSSCALESPDSVPVGICHGSLSESQGNPGKTISVTCSFFNSQAPTPRGENAAVNQRPAN PSKAEEPQQQNTASTNSPAKAVPKGSVQYLPDWDTKSEGSQEKDPVETFPVQLDLTTSPQGEPLDVSFLF LEPMEVKLVVLPFPSKEKRSAECPGPAQKNNPLILPP >XP_006260829.1 PREDICTED: fetuin-B [Alligator mississippiensis] MALLILLFLGIQALCSQAFSTPVKELQSPFLFPACNDSAVESAVDVALGQINTGRTEGYVLRLNRIFSVL EHPQETSGSVFYLILDVAETECHVLSRRLWKNCKTRPQHKTVFGQCRTTLYINNPKRIAHLHSYECTLRP VPTRSILMLCPDCPIFGCPTEPKYLETAVVSLAKFNSESTEAHYFSVLNVTKASMQWVVGPAYFVEFTIQ ETSCSRNESIADISKCKPLPFEKAHTGFCKGSVVNSQVDHHQFVNIDCEIYEPQVPAIEKQKETDSHKPG HGGDGSHEDPHHPRRKGAHPHQKHQHRHKQHEEKHPSPTEASEAALYLEKTVGWVKVLPPQQEHVSLHTL PESPVEYIDGNPVLPEVGMPVPDLPDIHGAPDGEKILTEGPGGKLGLIKPKTGPVFLSFPDELSHSDMCP GEPTTSNSFILNLLPRKHIKESPTATPLS >XP_020734453.1 fetuin-B [Odocoileus virginianus texanus] MSMLLLLALCTLATGCGASYPPQPANIPSPLLSLDCNSSYVLDIASDILQDINRDRNDGYVLSLNRVSDA REHRQGAGLGSLLYFTLDVLETGCHVLSRTPWKNCGVRFFHQSVYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRVVSMTCPDCPSTSPYDLSNPKYMEAANESLAKHNSRSPSKQYSLVKITKTFSQWVFGPAYFVEY LIKESPCTKSQGSSCALESPDSVPVGICHGSKSQSPKHPGKLISVNCSFFNSQAPTPRGENAAVNQRPEN PTKAEEPQQRNTAPTNSPTKAVLKGSVQYLHDWGKKPEDSQEKEPVETVPVQLDLTTNPQGEPLDVSFLF LEPMEEKLVVLPFPSKERRSAECPGPAQKDDPRLLPP >XP_043329405.1 fetuin-B [Cervus canadensis] MSVLLLLVLCTLAMGCGASYPPQPAIMPSPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGAGLG SLLYFTLDVLETGCHVLSRTPWKNCGVRLFHQSVYGQCKAIFYINKEKRIFYLAAYNCTLRPVSRRVISMTCPDCPSTSP YDLSNPRYMETATESLAKHNSGSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCTKSQGSSCALESPDSVPVGICHG SMSQSPVKPGKLISVNCSFFNSQAPTPRGENAAVNQRPANLTEAEEPQQQNTAPTNSPTKAVLKGSVQYLPDWGKKPEDS QEKEPVETVPVQLDLTTNPQGEHLDIPFLFLEPMEEQLVVLPFPSKGWRSAECPGPAQKDDPRLLPP >KAB0374112.1 hypothetical protein FD755_014368 [Muntiacus reevesi] MSVLLLLALCTLATGCGASYPPQPDINPSHLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREDRQRAGLG SLLYFTLDVLETGCHVLSRTPWKDCGVRFFHQSVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRRVVSMTCPDCPSTSP YDLSNPRFMETATESLAKHNSNSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCNKSQGSSCALESPDTVPVGICEG SMSQSPNSPGKLISVKCNFFNSQAPTPRGENVAVNQRPANPTEAEEPQQQNTAPTNSPTKAVLKGSVQFLPDWGKKLEDS QEKEPVETVPVQLDLTTNPQGEPLDLSFLFLEPMKEKLVVLPFPSKGWRSAECPGPAQKDDPRLLPP >KAB0359886.1 hypothetical protein FD754_004042 [Muntiacus muntjak] MSVLLLLALCTLATGCGASYPPQPDIRPSHRLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHKQGAGLG SLLYFTLDVLETGCHVLSRTPWKDCGVRLFHRSVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRRVVSMTCPDCPSTSP YDLSNPRFMETATESLAKYNSNSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCNKSQGSSCALESPDTVPVGICEG SMSQSPNSPGKLISVKCIFFNSQAPTPRGENVAVNQRPANPTEAEEPQQQNTAPTNSPTKAVLKGSVQFLPDWGKKLEDS QEKEPVETVPVQLDLTTNPQGEPLDLSFLFLEPMKEKLVVLPFPSKGWRSAECPGPAQKDDPRLLPP >XP_006017188.1 fetuin-B [Alligator sinensis] MALLILLFLGIQALCSQAFSPPVKELQSPFLFPACNDSAVESAVDVALGQINTGRTEGYMLRLNRIFSVLEHPQETSGSV FYLILDVAETECHVLSRRLWKNCKTRPQHKTVFGQCRATLYINNPKRIAHLHSYECTLRPVPTRSILMLCPDCPIFGCPT EPKYLETAVVSLAKFNRESTEAHYFSVLNVTKASMQWVVGPAYFVEFTIQETSCSRNESIADISKCKPLPFEKAHTGFCK GSVVNSQVDHHQFVNIDCEIYEPQVPAIEKQKETDSHKGHGGDGSHEDPHHPRRKGAHPHQKHQHRHKQHEEKHPSPTEA SEAALYLEKTVGWVKVLPPQQEHVSLHTLPESPVEYIDGNPVLPEVGKPVPDLPDIHGAPDGEKILTEGPGRQLGLIKPK TGPVFLSFPDELSHSDTCPGEPTTLNSFILNLLPRKHIKESPTATPLS >KAF4020911.1 hypothetical protein G4228_012704 [Cervus hanglu yarkandensis] MSVLLLLALCTLAMGCGASYPPQPAIMPSPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGAGLG SLLYFTLDVLETGCHVLSRTPWKNCGVRLFHQSWVFGPAYFVEYLIKESPCTKSQGSSCALESPDSVAPTPRGENAAVNQ RPANLTEAEEPQQQNTAPTNSPTKAVLKGSVQYLPDWGKKPEDSQEKEPVETVPVQLDLTTNPQGEHLDIPFLFLEPMEE KLVVLPFPSKGWRSAECPGPAQKDDPRLLPP >XP_018119101.1 fetuin-B [Xenopus laevis] MKMIFPVLLLVCTQVLGARALVAYSIRQPESSAVACNDSVVEAAADLSLRQLNGIRRKGFVFALHRITDAKEEFNIENGT VYQLTLDVVETECHVLSRQLWKDCEPKKLNEAVSGQCKTEFHIHKPRRIAHLHTYNCTLRQGPQRRGCPGCPMPTPLDDF RFLEVAKLSLKKYNSENNFNSYFSLANITRGRIQVVAGQAYHVEFTVRESSCNKTKSPKELDQCEILGSEDAATGYCKSF AVAHWSTPDDKKVQRVSCRIFNPEGTDAEQHSHDDGHHEHGHGDKKGHHGKKEDKHGKKEDKHGKKEDKHGKKHGDSEHA HGHKHGHKHKHGQKSSESHEDHSRNRTSSHSHNNKPKLVRPDPNAHTPTGSISYVTSEDDFPVPVNPSNSEHCPGQIKQY SPPAVPEAVPEAVPDAVPDALPKPTLIPK >XP_040205396.1 fetuin-B-like [Rana temporaria] MSWGRMKVCVLLLLCVHVLCTRAGRTRGPPEPELTSLACNDTQAEFAADLSLRQLNAHRKEGFSFGLKRISNVQEQYDEE NGSVFYLTLDVLEADCHVLSRKLWKECQSKPRNEAVFGQCKVIYQLNKPKRIAHLHYYDCTMTPAARDQPCPGCHFSKPL NDTNFVEVAKKSLLKFNSESNNSKYFLLGNITKAASQVVAGTAYHVEYTVQESTCNKSAEDLSQCEPLDCEFAHTGYCKA WAVAHWSSPADKAVQTISCDIFEPEAAIVEEQNHQGGHAEEKPGSGKRDHHGKGDRGKGKKHGHKHGHGHKHDHKHDHDH SGSHEHEHEHDHEHLHNYEHHHAPSRGGHGPKSESPKTKGTVTYITGDETSAASGAEDKKEKRGKPHKGGKGNQPKSFIR AFPDIASTSDQCPGQAKKFPVEDIPIIEAPQDPTTIPK >XP_015826648.1 PREDICTED: kininogen-1-like [Nothobranchius furzeri] MMKTCVLLLLVLGCVHGAPVGDTGLETGSCEDPSAVSAAHSALSKINLDRTEGYVFTLHRLSNVHLAKNGEVGVVYYLTL DVVETNCSVLSRKDWKDCETRSNPMQVYGQCKAAIYISKPHRVVRLYKYKCLVRPVPAARVVQICPDCPTFISQDNEEVK KTIANTLDKFNRESGLNNRFALLQVTRATAGMAMGMYYHVEYTIQETTCNKSTEAATADQCPMMGCEFAHKGFCKASLYY SPTRDPNYSVQCEIFEPEAANAEKVQHLLGDQLSHSHNDTHRHEHGKGHEHGKGHQHGKGHQHGKGHEHGKGHEHGKGHE HGKGRGHDHDHGNRRNWTSPHDHIHDHTKDHSHHDEMHPVGSDHHHSHDHKPGSAYKHGHAHSHDHGINHGLEHVHAYHA QAYDHSGDSPNHHHNYKHEEGTHTHEHDHELALDHDHKHGHLHEHEHHHHHHEHVHENETHDEPEGLSKKVGAIGEPVTT PIFPEEPPKAVILLLKLDPQIPGEAEPNILDFQSFPATLSSECVAPAPGQALVDKLFAEDDLFKPGNNF >XP_004068158.1 fetuin-B-like [Oryzias latipes] MMKICILGLLVLGCVHGAPVKEDLKPQSCDDPHAVKAAHVALTKINMDRNNGYIFSLHRLSNVHHSMHGENGVVYYLTMD VVETNCSVLSGKDWKHCEARPTSDQPVYGQCKAAIFINKVHRVDRLYKYDCVIKPVPSARVSALCPDCPTLISADNEQVQ KTLSLSLDKFNKESGLKNRFDKLKITRARAGMAMQMYYIVEYTIQETTCAHNTEGTEKCPLMTCEFAHKGFCKASLYSLP DNEQSINVECEIYESEASEGEKEEHLLGGETDHSHNDTHGHDHSTLPNHDHTYDHTKVHHHHNKTHEEADSHDHHHSHDH KPGSAYRHSHFHSHEHGVNHDPEHSHHTSAHNHTGDFPNHHHDYKHAEGVHTHDHDHELALDHEHKHAHLHDHEHHHHHH CHDHETTPHDTPVGSVRVLTDGPMILPSFPDQPAAGPNPGVVLPLRPDPQIPGAHEPIIQAFPRGISHECKAPAVKNNLV DQLFAEDPTFKPSA >XP_030289806.1 fetuin-B-like isoform X1 [Sparus aurata] MKHSVLLSLLLALGCMHVHGAPVEQDGMQQGSCEDAQAKGAAQQALNKINQDRQEGYVLGLHRLSNVHITKHDENGAVFY LTLDVVETNCSVLSRKDYKSCEARPVHDTPVYGQCKAAIFINRVQRVVRLYKYDCVIRPVPAARVSETCPDCPSHVAFDN AEVQKAVSLSLEKFNKESGLANHFSLLKISRATMGMAMSMYYNAEYTIQETTCPKSTEVVMAEKCPQMACEFAHKGLCRA SLFNIIGHTETSVQCEIYEPEWEGRASPDPPGCNSPEAVRVAEEALEQISQDRTDGYILSLNRLYDLSHTPDKEKGVSFY KLTIDVMETKCHITSRKPWKQCKVRDIGGVPVYGECEVSASIGSEVQLQSYACAIREVPATLVVAECPDCPTADNLNEPV VKETANLSLQRLNEESRLANYFTLENITRASSQWVFGPSYFVEFTIVETVCSRNTDASELSNCKPMDCQFAHRGFCLGTH VAMEDQFEIRPSVGNKDSSFPNRNAVEVECEIYEPQAAVVEEQAHVRGDSGHTVQQHNHTHLHPHEHMHSVTPSSDLAVS KPRGSLGTVVDQPAPVRSSPAASSCPSPHRHNLGIVKLRL
Mafft alignment of selected proteins >sp|Q9UGM5|FETUB_HUMAN Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2 ---------------------------------MGLLLPLALCILVLCC---GAMSPPQL ALNP---SALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRG-GLGS LFYLTLDVLETDCHVLRKKAWQDCGMRIFFES-VYGQCKAIFYMNNPSRVLYLAAYNCTL RPVSKKKIYMTCPDCPSSIPTDSSNHQVLEAATESLAKYNNENTSKQY-SLFKVTRASSQ WVVGPSYFVEYLIKESPCTKSQA----SSCSLQSSDSVPVGLCKGSLTRTH--------- --WE--KFVSVTCDFFESQ-------------APATGSENSAVNQKPT------------ ------------------------------------------------------------ ---------------------------------N-----LPKVEESQQKN---------- -------TPPTD-------------SPSKAGPRGSVQYLPDLDD--------------KN SQE-KGPQEAFPVHLDLTTN-------PQG-ETLDISFL------FLEPMEE-------- -----------------------------------KLVVLP-FPKEKAR----------- -----------------------TAECPGPAQNASPLVLPP------------------- ------ >tr|E7FE90|E7FE90_DANRE Fetuin B OS=Danio rerio OX=7955 GN=fetub PE=1 SV=1 M--------------------------------MKQCVVLVI---LLGFF--GVHGAPVE N--------LTPGSCQDAVTNGAAAEALNKINLDRKEGYVLGLDRLSNAFYMKHG-ETGI VFYLTLDVLETKCHVLSKKPWKSCEIRSPEEYPVYGQCKAVMYMNRVHRVARLYKYSCTV RPVPASKIQERCPDCPM--QLSGDNEEVLKTVKMGMEKYNNESGLNNYFAPLNITRASAS LHLGRFYTAEFTIQETVCSSKTKDVDVSKCELMACEFAHKGLCKASHSVT---------- --VTKEEHLNIQCEIFEPE-------------AAEEEKKKHLLGGEVDHSHTTGS----- -----STAHDHT------------------------------------------------ ---------------------------------------KTHTHEHSHEHT-HEHDH--- -------TKPHSH-----DHDHDHTKPHTHNHTHSHEHDHGHTHSHDHDHEH---TH--H AKAHEHGQDEWEHQHHQYGH-------KKD-ETHEHDHE-----IVLDHDHKHRH---IH EHEHHHHHHHDKSHQTKSRRPD---GIFNVLPPVDKPMILPSFPDKPAAGPEQPSTLPLL PDPEIPGQKEPTI---HTFPSKTSPECPAQSTIENGLLKQIV------------SEDPLF KPA--A >NP_067539.1 fetuin-B isoform 1 precursor [Mus musculus] ---------------------------------MGLLRLLVLCTLAACC---MARSPPAP PLPQRPLSPLHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREHYQE-DMGS LFYLTLDVLETDCHVLSRKAQKDCKPRMFYES-VYGQCKAMFHINKPRRVLYLPAYNCTL RPVSKRKTHTTCPDCPS--PIDLSNPSALEAATESLAKFNSKSPSKKY-ELVKVTKAMNQ WVSGPAYYVEYLIKEAPCTKSQ-----ASCSLQHSDSEPVGICQGSTVQSSLRHVPLIQP --VE--KSVTVTCEFFESQ-------------AQVPGDENPAVTQGPQ------------ ------------------------------------------------------------ ---------------------------------K-----LP------QKN---------- -------TAPTS-------------SPSVTAPRGSIQHLPELDDE-----------KPEE SKG-GSPEEAFPVQLDLTTN-------PQG-DTLDVSFL------YLEPGDK-------- -----------------------------------KLVVLP-FPGKEQR----------- -----------------------SAECPGPEKENNPLVLPP------------------- ------ >NP_001296451.1 fetuin-B isoform 1 precursor [Rattus norvegicus] -----------MISRFHRCGSVTSS-------GMGVLRLLVLCTLAACC---VARSPPAP PLPNAPFAPLRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVHDARVHRQE-DMGS LFYLMLDVLETGCHVLSRKALKDCGPRIFYET-VHGQCKAMFHVNKPRRVLYLPAYNCTL RPVSKRKIHSMCPDCPH--PVDLSAPSVLEAATESLAKFNSENPSKQY-ALVKVTKATTQ WVVGPSYFVEYLIKESPCTQSQ-----DSCSLQASDSEPVGLCQGSLIKSPG-----VPP QRFK--KTVTVSCEFFESQ-------------DQVPGGENPADTQDAK------------ ------------------------------------------------------------ ---------------------------------K-----LP------QKN---------- -------TAPTS-------------SPSITAPRGSIQHLPE--QE-----------EPED SKG-KSPEEPFPVQLDLTTN-------PQG-DTLDVSFL------YLEPEEK-------- -----------------------------------KLVVLP-FPGKEQR----------- -----------------------SPECPGPEKQRTP------------------------ ------ >NP_001264337.1 fetuin-B precursor [Gallus gallus] ---------------------------------MLLLISVLFGTQALCS---WAASPPAR ELP----SVLLSPTCHDAAVEEAADLALRQINADRTEGYILSLYRIFSVREHPQE-ITGS VFYLILDVVDTECHVLSKQLWKNCTVRPAHTT-VYGQCKAIIYINQSRKIAHLNTYECNL QPVPPRYIWGVCPDCPV--DDCPTEPRYLETAVKSLAKFNEESEQTHYFSVLNVTRGSMQ WVIGPAHFVEFLIQETSCSKRDPVADISKCKPLSPELAKIGFCKGSVVNSD--------- --MEHKQSVTISCEIYSSQ-------------DPVTGEGKLQTNQRPE------------ ------------------------------------------------------------ ----------------------------------------ESSQNHQQA----------- ------------------------FSLHLGKTTGCVKILPPSTEDISF---H---KLRES QNEHEDIKSVSAKAIECTSTPP----APDG-ETTHVDEP------GLTKPVT-------- -----------------------------------GPVILP-FPAELSL----------- -----------------------SDSCPGEAKQTDSILHPLLTRQ-------RAEV---- ------ >XP_001153966.1 fetuin-B [Pan troglodytes] ---------------------------------MGLLLPLALCILVLCC---RAMSPPQL ALNP---SALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQD-GLGS LFYLTLDVLETDCHVLSKKAWQDCGMRIFFES-VYGQCKAIFYMNNPSRVLYLAAYNCTL RPVSKKKIYMTCPDCPSSIPTDSSNRQVLEAATESLAKYNNENTSKQY-SLFKVTRASSQ WVVGPSYFVEYLIKESPCTKSQA----SSCSLQSSDSVPVGLCKGSLTRTH--------- --WE--KFVSVTCDFFESQ-------------APATGSENSAVNQKPI------------ ------------------------------------------------------------ ---------------------------------N-----LPKVEESQQKN---------- -------TPPTD-------------SPSKAGPRGNVQYLPDLDD--------------KN SQE-KGPQEAFPVHLDLTMN-------PQG-ETLDISFL------FLEPMEE-------- -----------------------------------KLVVLP-FPKEKAR----------- -----------------------TAECPGPAQNASPLILPP------------------- ------ >XP_535835.2 fetuin-B [Canis lupus familiaris] ---------------------------------MDLLLSLVLCTLAACC---WATSVPMP VLP----LPVLSRDCNNSGILEVAGFALQDINRDRKDGYVLSLNRVSDVREHRQV-AMGS LFYLTLDVLETDCHVLSRKPWKDCGVRHLHES-VYGQCKALFYVNKPGRVLYLPAYNCTL RPVSRRRIHNRCPDCPSPRATDLSDPTVLEAALESLAKYNSESTSKQY-SLVQVTRASSQ WVYGPAYFVEYLIKESPCTKSQV----SSCALQPPDSEPVGICKGSLGQRE--------- --LE--KFVSVTCHFFEPQ-------------VPAPGEENASASQGPV------------ ------------------------------------------------------------ ---------------------------------D-----LPGVGEFQQKN---------- -------TAPTN-------------SPSKAVPKGSVQYLPDLDDE----------KKPEG AQE-NSPVEAFPVKLDLTTD-------PQG-ESLDVSFL------FLGPMER-------- -----------------------------------KLVVLP-FPNKEQR----------- -----------------------SAECPGPAQQGNLLILPP------------------- ------ >NP_001029390.1 fetuin-B precursor [Bos taurus] ---------------------------------MNVLLLLVLCTLAMGC---GATSPPQP AARP---SSLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDAREHRQEAGLGS LFYFTLDVLETGCHVLSRTSWKNCEVRIFHES-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSQSAIIMTCPDCPSTSPYDLSNPRFMETATESLAKYNSESPSKQY-SLVKITKTSSQ WVFGPAYFVEYLIKESPCVKSEG----SSCALESPGSVPVGICHGSLGEPQ--------- --GNQGKIISVTCSFFNSQ-------------APTPRGENATVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----PSKTEELQQQN---------- -------TAPTN-------------SPTKAVPKGSVQYLPDWDK------------KREG SQE-KDPVETFPVQLDLTTN-------PQG-ESLDVSFL------FQEPMEE-------- -----------------------------------KVVVLP-FPSKEQR----------- -----------------------SAECPGPAQKGYPFILPS------------------- ------ >XP_008264796.1 PREDICTED: fetuin-B [Oryctolagus cuniculus] MGQPGSQNHSSLTLRRSTSQSVSAAPHPCFPLGMGLLQILGLCALAACC---GVVSVPQP FLKD---TPLLSRNCNDSDVLSVSGFALQDINRDQKDGYVLSLNRVSRVWEHTQD-HLGS VFYLVLDVLQTGCHVLSKKAWQDCAVRTLHTS-VYGQCKALFYINKPRRILYSIAYNCTL RPVSRRKIHSKCPDCPSPSRIDKSDPRVLEAAVESLAKFNRESTSKQY-SLVKVTKATSQ WMGSLAYFVEYLIQESPCTKSQA----GSCSLQPSDS-PVGLCKGTLIQNP--------- --LE--KRVTVTCDFFEQQ-------------APAPGTESLAGDQGPS------------ ------------------------------------------------------------ ---------------------------------N-----LPNVEELQQKI---------- -------TPPTD-------------TPSKVLSTGIVQHLPDLDDE-----------KPEG SQG-EGPPEAFPVQLELTTN-------PQG-ELLDVSFL------FLEPIEV-------- -----------------------------------KLVILP-FPKEDQH----------- -----------------------SGQCPGPAQNFDPLILPP------------------- ------ >XP_002832807.1 fetuin-B isoform X1 [Pongo abelii] ---------------------------------MGLLLPLALCTLVLCC---GAMSLPQL ALNP---SALLSRGCDDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQD-GLGS LFYLTLDVLETDCHVLSKKAWQDCGMRIFFES-VYGQCKAIFYMNNPSRVLYLAAYNCTL RPVSKKKIYMTCPDCPSSIPTDSSSRQVLEAATDSLAKYNNENTFKQY-SLFKVTRASSQ WVVGPSYFVEYLIKESPCTKSQA----SSCSLQSSDSVPVGLCKGSLTRTH--------- --WE--KFVSVTCDFFESQ-------------APATGSENSAVNQKPT------------ ------------------------------------------------------------ ---------------------------------N-----LPKVEESQQKN---------- -------TPPTD-------------SPSKAGPRGSVQYLPDLDD--------------KN SQE-KGSQEAFPVHLDLTTN-------PQG-ETLDLSFL------FLEPMEE-------- -----------------------------------KLVVLP-FPKEKAR----------- -----------------------TAECPGPAQNASPLVLPP------------------- ------ >XP_003132625.1 fetuin-B [Sus scrofa] ---------------------------------MGLLLPLVLCALAVGC---GATSPPQP LPPTS--SLLLSHACNSSYVLDVVNLVLQEINRNQKDGYVLSPNRVSDVREHRQG-DLGS LFYLTLDVIESSCHVLSKMSWKDCGLTPFHES-EYGQCKAIFYINKARRIHYLPAYNCIL RPVSPGQLVTLCPDCPT--HVNMSDTKVLEAATKSLEEFNKRRTSKKY-SLVKVTRALFQ WVFGPAYFVEYLIKESPCTKSQA----SSCALQPPNPEPVGICSGSRSERG--------- --PE--KFVSVRCSFFKSQ-------------APTPGDAYSTASRG-------------- ------------------------------------------------------------ ---------------------------------D-----PTKVEEPQQES---------- -------TA-----------------SAKPVPKGSVQHLPGLGD------------KPKG SPE-TGPEEAFPVRVDLTSN-------PQG-EPLDVSFL------FPEPVEK-------- -----------------------------------DLVVLP-FPSREWR----------- -----------------------SAECPGPARVSNPLVLPP------------------- ------ >XP_003209226.1 fetuin-B [Meleagris gallopavo] ---------------------------------MLLFISVLLGTQALCS---WAASPPAR ELP----SVLLSPSCHDAAVEEAADLALRQINADRTEGYILSLYRILSVREHPQE-ITGS VFYLILDVVDTECHVLSKQLWKNCRVRPAHTT-VYGQCKAIIYINQPRKIAHLNTYECNL QPVPPRYIWEVCPDCPV--DDCPTEPKYLETAVKSLAKFNEESEQTHYFSVLNVTRASMQ WVIGPAHFVEFVIQETSCPKREPAADVSKCKPLSPELAQMGFCKGSVVNSD--------- --MEQKETITISCEIYSPQ-------------DPVTEEGKLQTNQGSE------------ ------------------------------------------------------------ ----------------------------------------ESSQNHQQAF---------- ---------PAET---------NPFSLHLGKTMGCVKILPPSTEDISF---H---KLRES QNEQEDRKPVPPRAIECVSTPP----APDG-ETTHID-----------KPVT-------- -----------------------------------GPVILP-FPAEVSL----------- -----------------------SDSCPGEAKQIDSILHPLLTGK-------PAKV---- ------ >XP_034813758.1 fetuin-B isoform X1 [Pan paniscus] ---------------------------------MGLLLPLALCIQVLCC---RAMSPPQL ALNP---SALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQD-GLGS LFYLTLDVLETDCHVLSKKAWQDCGMRIFFES-VYGQCKAIFYMNNPSRVLYLAAYNCTL RPVSKKKIYMMCPDCPSSIPTDSSNRQVLEAATESLAKY-NENTSKQY-SLFKVTRASSQ WVVGPSYFVEYLIKESPCTKSQA----SSCSLQSSDSVPVGLCKGSLTRTH--------- --WE--KFVSVTCDFFESQ-------------APATGSENSAVNQKPI------------ ------------------------------------------------------------ ---------------------------------N-----LPKVEESQQKN---------- -------TPPTD-------------SPSKAGPRGNVQYLPDLDD--------------KN SQE-KGPQEAFPVHLDLTMN-------PQG-ETLDISFL------FLEPMEE-------- -----------------------------------KLVVLP-FPKEKAR----------- -----------------------TAECPGPAQNASPLILPP------------------- ------ >XP_019695567.1 fetuin-B isoform X2 [Felis catus] ---------------------------------MGLLLPVVLCALAACC---GATSPPLR F------WPPIAHGCNDSGILELAGFALQDINRDRKDGYVLSLNRVSDVREHRQVNSLGS LFYFTLDVLETDCHVLSRKAWKDCGVRTLHKS-VYGQCKALFYVNRPGRVLYVLAYNCTL RPVSRRSIHMMCPDCPS--PFKLSNPKVLETAAESLAKYNKESASKQY-SLFQVTRASGQ WVFGFAFFVEYLIKESPCTKHQA----SSCALQPPDSVPVGLCKGTLTERQ--------- --LQ--KFVSVTCDFFEPQ-------------APAPGGENPAANQGPA------------ ------------------------------------------------------------ ---------------------------------D-----LPTVEESQQKI---------- -------IAPTN-------------SPSKAVPKGSVQYLPDLDDE-----------KPED AQE-NSPLEAFPVQLELTTD-------PLG-ESLDVSFL------FLDPEEK-------- -----------------------------------KVVVLP-FPKKEQR----------- -----------------------SAECPGPAQQANPLVLPP------------------- ------ >XP_004003110.1 fetuin-B [Ovis aries] ---------------------------------MSVLLLLVLCTLAMGC---GAASPPQP AARP---SPLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDAREHRQEAGLGS LFYFTLDVLETGCHVLSRTSWKNCGVRIFHES-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRAIIMMCPDCPSTSPYDLSNPRYMETATESLAKYNSRSPSKQY-SVVKITKTFSQ WVFGPAYFVEYLIKESPCTKSQG----SSCALESPDSVPVGICHGSLSQSQ--------- --GNPGKTISVTCSFFNSQ-------------APTPRGENAAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----PSKAEEPQQQN---------- -------TASTN-------------SPAKAVLKGSVQYLPDWDK------------KSEG SQE-KDPVETFPVQLDLTTN-------PQG-EPLDVSFL------FLEPMEV-------- -----------------------------------KLVVLP-FPSKEKR----------- -----------------------SAECPGPAQKDNPLILPP------------------- ------ >XP_004038216.1 fetuin-B [Gorilla gorilla gorilla] ---------------------------------MGLLLPLALCILVLCC---GAMSPPQL ALNP---SALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQD-GLGS LFYLALDVLETDCHVLSKKAGQDCGMRIFFES-VYGQCKAIFYMNNPSRVLYLAAYNCTL RPVSKKKIYMTCPDCPSSIPTDSSNRQVLEAATESLAKYNNENTSKQY-SLFKVTRASSQ WVVGPSYFVEYLIKESPCTKSQA----SSCSLQSSDSVPVGLCKGSLTRTH--------- --WE--KFVSVTCDFFELQ-------------APATGSENSAVNQKPT------------ ------------------------------------------------------------ ---------------------------------N-----LPKVEESQQKN---------- -------TPPTD-------------SPSKAGPRGSVQYLPELDD--------------KN SQE-KGPQEAFPVHLDLTTN-------PQG-ETLDISFL------FLEPMEE-------- -----------------------------------KLVVLP-FPKEKAR----------- -----------------------TAECPGPAQNASPLVLPP------------------- ------ >XP_005506654.1 fetuin-B [Columba livia] ---------------------------------MVSLVLLLFGTQALCS---WAAA-HAS EAR----AAFLSSPCNTTAAEEAADLALRQINADRREGYVLRLYRIFSVQEHPQE-ISSS AFYLVLDVVDTECHVLSKKLWKNCKARPAHGT-VYGQCKAIIYINQARNIAHLNNYECIL QPVPPRYIWSVCPDCPV--DDGPTEPKYLEAAVQSLAKFNEESEQAHYFSVLNVTRASMQ WVIGPAYFVEFLIQETSCSKNDTIADISKCKPLSSELAQIGFCKGSVENSD--------- --LEHEQFVTISCEIYNLQ-------------DPATEEGKQQAKQTPG------------ ------------------------------------------------------------ ----------------------------------------KSSQSHQQAF---------- ---------PSET---------NPFSPYLEKTVGLVKILPASTEDTYF---Q---RLPES QTKRKDGKPVLPEAVRSTST-------LDG-QKTQVDKS------DLTNPVT-------- -----------------------------------GPVILP-FPEELSL----------- -----------------------SDSCPGEAKEVNSILQPLLPKK-------YTKV---- ------ >XP_005675217.2 PREDICTED: fetuin-B [Capra hircus] ---------------------------------MSVLLLLVLCTLAMGC---GAASPPQP ASRP---SPLLSLDCNSSYVLDIANDILQDINRDRKDGYMLSLNRVSDAREHRQEAGLGS LFYFTLDVLETGCHVLSRTSWKNCGVRIFHES-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRSAIIMMCPDCPSTSPYDLSNPRYMETATESLAKYNSRSPSKQY-SVVKITKTFSQ WVFGPAYFVEYLIKESPCTKSQG----SSCALESPDSVPVGICHGSLSESQ--------- --GNPGKTISVTCSFFNSQ-------------APTPRGENAAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----PSKAEEPQQQN---------- -------TASTN-------------SPAKAVPKGSVQYLPDWDT------------KSEG SQE-KDPVETFPVQLDLTTS-------PQG-EPLDVSFL------FLEPMEV-------- -----------------------------------KLVVLP-FPSKEKR----------- -----------------------SAECPGPAQKNNPLILPP------------------- ------ >XP_006260829.1 PREDICTED: fetuin-B [Alligator mississippiensis] ---------------------------------MALLILLFLGIQALCS---QAFSTPVK ELQ----SPFLFPACNDSAVESAVDVALGQINTGRTEGYVLRLNRIFSVLEHPQE-TSGS VFYLILDVAETECHVLSRRLWKNCKTRPQHKT-VFGQCRTTLYINNPKRIAHLHSYECTL RPVPTRSILMLCPDCPI--FGCPTEPKYLETAVVSLAKFNSESTEAHYFSVLNVTKASMQ WVVGPAYFVEFTIQETSCSRNESIADISKCKPLPFEKAHTGFCKGSVVNSQ--------- --VDHHQFVNIDCEIYEPQ-------------VPAIEKQKETDSHKPGHG-GDG------ -----SHEDPHH------------------------------------------------ -----------------------------PRRKG-----AHPHQKHQHRHKQHEEKH--- -------PSPTEA---------SEAALYLEKTVGWVKVLPPQQEHVSL---H---TLPES PVEYIDGNPVLPEVGMPVPDLPDIHGAPDG-EKILTEGPG--GKLGLIKPKT-------- -----------------------------------GPVFLS-FPDELSH----------- -----------------------SDMCPGEPTTSNSFILNLLPRK-------HIKESPTA TPL--S >XP_020734453.1 fetuin-B [Odocoileus virginianus texanus] ---------------------------------MSMLLLLALCTLATGC---GASYPPQP ANIP---SPLLSLDCNSSYVLDIASDILQDINRDRNDGYVLSLNRVSDAREHRQGAGLGS LLYFTLDVLETGCHVLSRTPWKNCGVRFFHQS-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRVVSMTCPDCPSTSPYDLSNPKYMEAANESLAKHNSRSPSKQY-SLVKITKTFSQ WVFGPAYFVEYLIKESPCTKSQG----SSCALESPDSVPVGICHGSKSQSP--------- --KHPGKLISVNCSFFNSQ-------------APTPRGENAAVNQRPE------------ ------------------------------------------------------------ ---------------------------------N-----PTKAEEPQQRN---------- -------TAPTN-------------SPTKAVLKGSVQYLHDWGK------------KPED SQE-KEPVETVPVQLDLTTN-------PQG-EPLDVSFL------FLEPMEE-------- -----------------------------------KLVVLP-FPSKERR----------- -----------------------SAECPGPAQKDDPRLLPP------------------- ------ >XP_043329405.1 fetuin-B [Cervus canadensis] ---------------------------------MSVLLLLVLCTLAMGC---GASYPPQP AIMP---SPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGAGLGS LLYFTLDVLETGCHVLSRTPWKNCGVRLFHQS-VYGQCKAIFYINKEKRIFYLAAYNCTL RPVSRRVISMTCPDCPSTSPYDLSNPRYMETATESLAKHNSGSPSKQY-SLVKITKTFSQ WVFGPAYFVEYLIKESPCTKSQG----SSCALESPDSVPVGICHGSMSQSP--------- --VKPGKLISVNCSFFNSQ-------------APTPRGENAAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----LTEAEEPQQQN---------- -------TAPTN-------------SPTKAVLKGSVQYLPDWGK------------KPED SQE-KEPVETVPVQLDLTTN-------PQG-EHLDIPFL------FLEPMEE-------- -----------------------------------QLVVLP-FPSKGWR----------- -----------------------SAECPGPAQKDDPRLLPP------------------- ------ >KAB0374112.1 hypothetical protein FD755_014368 [Muntiacus reevesi] ---------------------------------MSVLLLLALCTLATGC---GASYPPQP DINP---SHLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREDRQRAGLGS LLYFTLDVLETGCHVLSRTPWKDCGVRFFHQS-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRVVSMTCPDCPSTSPYDLSNPRFMETATESLAKHNSNSPSKQY-SLVKITKTFSQ WVFGPAYFVEYLIKESPCNKSQG----SSCALESPDTVPVGICEGSMSQSP--------- --NSPGKLISVKCNFFNSQ-------------APTPRGENVAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----PTEAEEPQQQN---------- -------TAPTN-------------SPTKAVLKGSVQFLPDWGK------------KLED SQE-KEPVETVPVQLDLTTN-------PQG-EPLDLSFL------FLEPMKE-------- -----------------------------------KLVVLP-FPSKGWR----------- -----------------------SAECPGPAQKDDPRLLPP------------------- ------ >KAB0359886.1 hypothetical protein FD754_004042 [Muntiacus muntjak] ---------------------------------MSVLLLLALCTLATGC---GASYPPQP DIRP---SHRLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHKQGAGLGS LLYFTLDVLETGCHVLSRTPWKDCGVRLFHRS-VYGQCKAIFYINKEKRIFYLPAYNCTL RPVSRRVVSMTCPDCPSTSPYDLSNPRFMETATESLAKYNSNSPSKQY-SLVKITKTFSQ WVFGPAYFVEYLIKESPCNKSQG----SSCALESPDTVPVGICEGSMSQSP--------- --NSPGKLISVKCIFFNSQ-------------APTPRGENVAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----PTEAEEPQQQN---------- -------TAPTN-------------SPTKAVLKGSVQFLPDWGK------------KLED SQE-KEPVETVPVQLDLTTN-------PQG-EPLDLSFL------FLEPMKE-------- -----------------------------------KLVVLP-FPSKGWR----------- -----------------------SAECPGPAQKDDPRLLPP------------------- ------ >XP_006017188.1 fetuin-B [Alligator sinensis] ---------------------------------MALLILLFLGIQALCS---QAFSPPVK ELQ----SPFLFPACNDSAVESAVDVALGQINTGRTEGYMLRLNRIFSVLEHPQE-TSGS VFYLILDVAETECHVLSRRLWKNCKTRPQHKT-VFGQCRATLYINNPKRIAHLHSYECTL RPVPTRSILMLCPDCPI--FGCPTEPKYLETAVVSLAKFNRESTEAHYFSVLNVTKASMQ WVVGPAYFVEFTIQETSCSRNESIADISKCKPLPFEKAHTGFCKGSVVNSQ--------- --VDHHQFVNIDCEIYEPQ-------------VPAIEKQKETDSHK-GHG-GDG------ -----SHEDPHH------------------------------------------------ -----------------------------PRRKG-----AHPHQKHQHRHKQHEEKH--- -------PSPTEA---------SEAALYLEKTVGWVKVLPPQQEHVSL---H---TLPES PVEYIDGNPVLPEVGKPVPDLPDIHGAPDG-EKILTEGPG--RQLGLIKPKT-------- -----------------------------------GPVFLS-FPDELSH----------- -----------------------SDTCPGEPTTLNSFILNLLPRK-------HIKESPTA TPL--S >KAF4020911.1 hypothetical protein G4228_012704 [Cervus hanglu yarkandensis] ---------------------------------MSVLLLLALCTLAMGC---GASYPPQP AIMP---SPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGAGLGS LLYFTLDVLETGCHVLSRTPWKNCGVRLFHQS---------------------------- ------------------------------------------------------------ WVFGPAYFVEYLIKESPCTKSQG----SSCALESPDSV---------------------- --------------------------------APTPRGENAAVNQRPA------------ ------------------------------------------------------------ ---------------------------------N-----LTEAEEPQQQN---------- -------TAPTN-------------SPTKAVLKGSVQYLPDWGK------------KPED SQE-KEPVETVPVQLDLTTN-------PQG-EHLDIPFL------FLEPMEE-------- -----------------------------------KLVVLP-FPSKGWR----------- -----------------------SAECPGPAQKDDPRLLPP------------------- ------ >XP_018119101.1 fetuin-B [Xenopus laevis] M----K---------------------------MIFPVLLLVCTQVLGARALVAYSIRQP E--------SSAVACNDSVVEAAADLSLRQLNGIRRKGFVFALHRITDAKEEFNI-ENGT VYQLTLDVVETECHVLSRQLWKDCEPKKLNEA-VSGQCKTEFHIHKPRRIAHLHTYNCTL RQGPQRR---GCPGCPM--PTPLDDFRFLEVAKLSLKKYNSENNFNSYFSLANITRGRIQ VVAGQAYHVEFTVRESSCNKTKSPKELDQCEILGSEDAATGYCKSFAVAHWS-----T-- --PDDKKVQRVSCRIFNPE-------------GTDAEQHSHDDGHHEH---GHG------ ------DKKGHH---------------------------------------GKKE----- --------------------------DKHGKKEDK---HGKKEDKHGKKHGDSEHAH--- --------------------GHKHGHKHKHGQKSSESHE-DHSRNRTSSHSH---NNKPK LVR-PDPNAHTP--TGSISY-------VTS-ED------------------D-------- ---------------------------------------FP-VPVNPSN----------- -----------------------SEHCPGQIKQYSPPAVPEAVPEAVPDAVPDALPKPTL IPK--- >XP_040205396.1 fetuin-B-like [Rana temporaria] M-SWGR---------------------------MKVCVLLLLCVHVLCTRAGRTRGPPEP E--------LTSLACNDTQAEFAADLSLRQLNAHRKEGFSFGLKRISNVQEQYDE-ENGS VFYLTLDVLEADCHVLSRKLWKECQSKPRNEA-VFGQCKVIYQLNKPKRIAHLHYYDCTM TPAARDQ---PCPGCHF--SKPLNDTNFVEVAKKSLLKFNSESNNSKYFLLGNITKAASQ VVAGTAYHVEYTVQESTCNKSAE--DLSQCEPLDCEFAHTGYCKAWAVAHWS-----S-- --PADKAVQTISCDIFEPE-------------AAIVEEQNHQGGHAEE---KPG------ -----SGKRDHH---------------------------------------GKGD----- ---------------------------------------RGKGKKHGHKHG-----H--- --------------------GHKHDHKHDHDHSGSHEHEHEHDHEHLHNYEH---HHAPS RGG-HGPKSESPKTKGTVTY-------ITG-DETSAASG------AEDKKEKRGK---PH KGGKGNQP---------------------------KSFIRA-FPDIAST----------- -----------------------SDQCPGQAKKFPVEDIPII----------EAPQDPTT IPK--- >XP_015826648.1 PREDICTED: kininogen-1-like [Nothobranchius furzeri] M--------------------------------MKTCVLLLL---VLGC----VHGAPVG D------TGLETGSCEDPSAVSAAHSALSKINLDRTEGYVFTLHRLSNVHLAKNG-EVGV VYYLTLDVVETNCSVLSRKDWKDCETRSNPMQ-VYGQCKAAIYISKPHRVVRLYKYKCLV RPVPAARVVQICPDCPT--FISQDNEEVKKTIANTLDKFNRESGLNNRFALLQVTRATAG MAMGMYYHVEYTIQETTCNKSTEAATADQCPMMGCEFAHKGFCKASLYYS---------- --PTRDPNYSVQCEIFEPE-------------AANAEKVQHLLGDQLSHSHND------- -----THRHEHGKGHEHGK---GHQHGKGH-QHGKGHEHGKGHEHGKGHEHGKGR----- ----------------------GHDHD-HGNRRN-----WTSPHDHIHDHT-KDHSHH-- -----DEMHPVGS-------DHHHSHDHKPGSAYKHGHAHSHDHGINHGLEH---VHAYH AQAYDHSGD-SPNHHHNYKH-------EEGTHTHEHDHE-----LALDHDHKHGH---LH EHEHHHHHHEHVHENETHDEPE---GLSKKVGAIGEPVTTPIFPEEPPK----AVILLLK LDPQIPGEAEPNILDFQSFPATLSSECVAPAPG-QALVDKLF------------AEDDLF KPGNNF >XP_004068158.1 fetuin-B-like [Oryzias latipes] M--------------------------------MKICILGLL---VLGC----VHGAPVK E------D-LKPQSCDDPHAVKAAHVALTKINMDRNNGYIFSLHRLSNVHHSMHG-ENGV VYYLTMDVVETNCSVLSGKDWKHCEARPTSDQPVYGQCKAAIFINKVHRVDRLYKYDCVI KPVPSARVSALCPDCPT--LISADNEQVQKTLSLSLDKFNKESGLKNRFDKLKITRARAG MAMQMYYIVEYTIQETTCAHNTEG--TEKCPLMTCEFAHKGFCKASLYSL---------- --PDNEQSINVECEIYESE-------------ASEGEKEEHLLGGETDHSHND------- -----THGHDHS------------------------------------------------ ---------------------------------------TLPNHDHTYDHT-KVHHHH-- -----NKTHEEAD-----SHDHHHSHDHKPGSAYRHSHFHSHEHGVNHDPEH---SH--H TSAHNHTGD-FPNHHHDYKH-------AEGVHTHDHDHE-----LALDHEHKHAH---LH DHEHHHHHHCHDHETTPHDTPV---GSVRVL--TDGPMILPSFPDQPAAGPNPGVVLPLR PDPQIPGAHEPII---QAFPRGISHECKAPAVK-NNLVDQLF------------AEDPTF KPS--A >XP_030289806.1 fetuin-B-like isoform X1 [Sparus aurata] ---------------------------------MKHSVLLSL-LLALGCM--HVHGAPVE Q------DGMQQGSCEDAQAKGAAQQALNKINQDRQEGYVLGLHRLSNVHITKHD-ENGA VFYLTLDVVETNCSVLSRKDYKSCEARPVHDTPVYGQCKAAIFINRVQRVVRLYKYDCVI RPVPAARVSETCPDCPS--HVAFDNAEVQKAVSLSLEKFNKESGLANHFSLLKISRATMG MAMSMYYNAEYTIQETTCPKSTEVVMAEKCPQMACEFAHKGLCRASLFN----------- --IIGHTETSVQCEIYEPEWEGRASPDPPGCNSPEAVRVAEEALEQISQDRTDGYILSLN RLYDLSHTPDKEKGVSFYKLTIDVMETKCHITSRKPWKQCKVRDIGGVPVYGECEVSASI GSEVQLQSYACAIREVPATLVVAECPD-CPTADNLNEPVVKETANLSLQRL-NEESRLAN YFTLENITRASSQWVFGPSYFVEFTIVETVCSRNTDASELSNCKPMDCQFAHRGFCLGTH VAM-EDQFEIRPSVGNKDSS------FPNR-NAVEVECEIYEPQAAVVEEQAHVRGDSGH TVQQHNHTHLHPHEHMHSVTPSSDLAVSKPRGSLGTVVDQP-APVRSSPA---------- -----------------------ASSCPSPHRHNLGIVKLRL------------------ ------
BMGE Cleaned alignment of selected proteins >sp|Q9UGM5|FETUB_HUMAN Fetuin-B OS=Homo sapiens OX=9606 GN=FETUB PE=1 SV=2 MGLLLPLALCILVLCCGAMSPPQSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRRGGLGSLFYLTLDVLETDCHVLRKKAWQDCGMRIVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKTCPDCPSSSNHQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQSSCSLQSSDSVPVGLCKGSL-KFVSVTCDFFESQAPATGSENSEESQQKNTPPTDSPSKAGPRGSVQYLPDLDD-KGPQEAFPVHLDLTTNETLDISFLFLEPMKLVVLPTAECPGPAQPLVLPP >tr|E7FE90|E7FE90_DANRE Fetuin B OS=Danio rerio OX=7955 GN=fetub PE=1 SV=1 MKQCVVLVI---LLGFGVHGAPV--LTPGSCQDAVTNGAAAEALNKINLDRKEGYVLGLDRLSNAFYMKHGETGIVFYLTLDVLETKCHVLSKKPWKSCEIRSVYGQCKAVMYMNRVHRVARLYKYSCTVRPVPARCPDCPMGDNEEVLKTVKMGMEKYNNESGLNNYAPLNITRASASLHLGRFYTAEFTIQETVCSSKTSKCELMACEFAHKGLCKASHEEHLNIQCEIFEPEAAEEEKKKHHEHSHEHTKPHSKPHTHNHTHSHEHDHGHTHSEHGQDEWEHQHHQYGHETHEHDHEVLDHDKPMILPSPECPAQSTGLLKQI >NP_067539.1 fetuin-B isoform 1 precursor [Mus musculus] MGLLRLLVLCTLAACCMARSPPASPLHPLGCNDSEVLAVAGFALQNINRDQKDGYMLSLNRVHDVREHYQEDMGSLFYLTLDVLETDCHVLSRKAQKDCKPRMVYGQCKAMFHINKPRRVLYLPAYNCTLRPVSKTCPDCPSLSNPSALEAATESLAKFNSKSPSKKYELVKVTKAMNQWVSGPAYYVEYLIKEAPCTKSQASCSLQHSDSEPVGICQGST-KSVTVTCEFFESQAQVPGDENP----QKNTAPTSSPSVTAPRGSIQHLPELDDEGSPEEAFPVQLDLTTNDTLDVSFLYLEPGKLVVLPSAECPGPEKPLVLPP >NP_001296451.1 fetuin-B isoform 1 precursor [Rattus norvegicus] MGVLRLLVLCTLAACCVARSPPAAPLRPLGCNDSEVLAVAGFALQNINRVQKDGYMLTLNRVHDARVHRQEDMGSLFYLMLDVLETGCHVLSRKALKDCGPRIVHGQCKAMFHVNKPRRVLYLPAYNCTLRPVSKMCPDCPHLSAPSVLEAATESLAKFNSENPSKQYALVKVTKATTQWVVGPSYFVEYLIKESPCTQSQDSCSLQASDSEPVGLCQGSL-KTVTVSCEFFESQDQVPGGENP----QKNTAPTSSPSITAPRGSIQHLPE--QEKSPEEPFPVQLDLTTNDTLDVSFLYLEPEKLVVLPSPECPGPEKP----- >NP_001264337.1 fetuin-B precursor [Gallus gallus] MLLLISVLFGTQALCSWAASPPASVLLSPTCHDAAVEEAADLALRQINADRTEGYILSLYRIFSVREHPQEITGSVFYLILDVVDTECHVLSKQLWKNCTVRPVYGQCKAIIYINQSRKIAHLNTYECNLQPVPPVCPDCPVPTEPRYLETAVKSLAKFNEESEQTHYSVLNVTRGSMQWVIGPAHFVEFLIQETSCSKRDSKCKPLSPELAKIGFCKGSVKQSVTISCEIYSSQDPVTGEGKLQNHQQA------SLHLGKTTGCVKILPPSTEDEDIKSVSAKAIECTSTETTHVDEPGLTKPGPVILPSDSCPGEAKSILHPL >XP_001153966.1 fetuin-B [Pan troglodytes] MGLLLPLALCILVLCCRAMSPPQSALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKTCPDCPSSSNRQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQSSCSLQSSDSVPVGLCKGSL-KFVSVTCDFFESQAPATGSENSEESQQKNTPPTDSPSKAGPRGNVQYLPDLDD-KGPQEAFPVHLDLTMNETLDISFLFLEPMKLVVLPTAECPGPAQPLILPP >XP_535835.2 fetuin-B [Canis lupus familiaris] MDLLLSLVLCTLAACCWATSVPMLPVLSRDCNNSGILEVAGFALQDINRDRKDGYVLSLNRVSDVREHRQVAMGSLFYLTLDVLETDCHVLSRKPWKDCGVRHVYGQCKALFYVNKPGRVLYLPAYNCTLRPVSRRCPDCPSLSDPTVLEAALESLAKYNSESTSKQYSLVQVTRASSQWVYGPAYFVEYLIKESPCTKSQSSCALQPPDSEPVGICKGSL-KFVSVTCHFFEPQVPAPGEENAGEFQQKNTAPTNSPSKAVPKGSVQYLPDLDDENSPVEAFPVKLDLTTDESLDVSFLFLGPMKLVVLPSAECPGPAQLLILPP >NP_001029390.1 fetuin-B precursor [Bos taurus] MNVLLLLVLCTLAMGCGATSPPQSSLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDAREHRQEGLGSLFYFTLDVLETGCHVLSRTSWKNCEVRIVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSQTCPDCPSLSNPRFMETATESLAKYNSESPSKQYSLVKITKTSSQWVFGPAYFVEYLIKESPCVKSESSCALESPGSVPVGICHGSLGKIISVTCSFFNSQAPTPRGENAEELQQQNTAPTNSPTKAVPKGSVQYLPDWDK-KDPVETFPVQLDLTTNESLDVSFLFQEPMKVVVLPSAECPGPAQPFILPS >XP_008264796.1 PREDICTED: fetuin-B [Oryctolagus cuniculus] MGLLQILGLCALAACCGVVSVPQTPLLSRNCNDSDVLSVSGFALQDINRDQKDGYVLSLNRVSRVWEHTQDHLGSVFYLVLDVLQTGCHVLSKKAWQDCAVRTVYGQCKALFYINKPRRILYSIAYNCTLRPVSRKCPDCPSKSDPRVLEAAVESLAKFNRESTSKQYSLVKVTKATSQWMGSLAYFVEYLIQESPCTKSQGSCSLQPSDS-PVGLCKGTL-KRVTVTCDFFEQQAPAPGTESLEELQQKITPPTDTPSKVLSTGIVQHLPDLDDEEGPPEAFPVQLELTTNELLDVSFLFLEPIKLVILPSGQCPGPAQPLILPP >XP_002832807.1 fetuin-B isoform X1 [Pongo abelii] MGLLLPLALCTLVLCCGAMSLPQSALLSRGCDDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKTCPDCPSSSSRQVLEAATDSLAKYNNENTFKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQSSCSLQSSDSVPVGLCKGSL-KFVSVTCDFFESQAPATGSENSEESQQKNTPPTDSPSKAGPRGSVQYLPDLDD-KGSQEAFPVHLDLTTNETLDLSFLFLEPMKLVVLPTAECPGPAQPLVLPP >XP_003132625.1 fetuin-B [Sus scrofa] MGLLLPLVLCALAVGCGATSPPQSLLLSHACNSSYVLDVVNLVLQEINRNQKDGYVLSPNRVSDVREHRQGDLGSLFYLTLDVIESSCHVLSKMSWKDCGLTPEYGQCKAIFYINKARRIHYLPAYNCILRPVSPLCPDCPTMSDTKVLEAATKSLEEFNKRRTSKKYSLVKVTRALFQWVFGPAYFVEYLIKESPCTKSQSSCALQPPNPEPVGICSGSR-KFVSVRCSFFKSQAPTPGDAYSEEPQQESTA----SAKPVPKGSVQHLPGLGD-TGPEEAFPVRVDLTSNEPLDVSFLFPEPVDLVVLPSAECPGPARPLVLPP >XP_003209226.1 fetuin-B [Meleagris gallopavo] MLLFISVLLGTQALCSWAASPPASVLLSPSCHDAAVEEAADLALRQINADRTEGYILSLYRILSVREHPQEITGSVFYLILDVVDTECHVLSKQLWKNCRVRPVYGQCKAIIYINQPRKIAHLNTYECNLQPVPPVCPDCPVPTEPKYLETAVKSLAKFNEESEQTHYSVLNVTRASMQWVIGPAHFVEFVIQETSCPKRESKCKPLSPELAQMGFCKGSVKETITISCEIYSPQDPVTEEGKLQNHQQAF--PAESLHLGKTMGCVKILPPSTEDEDRKPVPPRAIECVSTETTHID-----KPGPVILPSDSCPGEAKSILHPL >XP_034813758.1 fetuin-B isoform X1 [Pan paniscus] MGLLLPLALCIQVLCCRAMSPPQSALLSRGCSDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQDGLGSLFYLTLDVLETDCHVLSKKAWQDCGMRIVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKMCPDCPSSSNRQVLEAATESLAKY-NENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQSSCSLQSSDSVPVGLCKGSL-KFVSVTCDFFESQAPATGSENSEESQQKNTPPTDSPSKAGPRGNVQYLPDLDD-KGPQEAFPVHLDLTMNETLDISFLFLEPMKLVVLPTAECPGPAQPLILPP >XP_019695567.1 fetuin-B isoform X2 [Felis catus] MGLLLPVVLCALAACCGATSPPLWPPIAHGCNDSGILELAGFALQDINRDRKDGYVLSLNRVSDVREHRQVSLGSLFYFTLDVLETDCHVLSRKAWKDCGVRTVYGQCKALFYVNRPGRVLYVLAYNCTLRPVSRMCPDCPSLSNPKVLETAAESLAKYNKESASKQYSLFQVTRASGQWVFGFAFFVEYLIKESPCTKHQSSCALQPPDSVPVGLCKGTL-KFVSVTCDFFEPQAPAPGGENPEESQQKIIAPTNSPSKAVPKGSVQYLPDLDDENSPLEAFPVQLELTTDESLDVSFLFLDPEKVVVLPSAECPGPAQPLVLPP >XP_004003110.1 fetuin-B [Ovis aries] MSVLLLLVLCTLAMGCGAASPPQSPLLSLDCNSSYVLDIANDILQDINRDRKDGYVLSLNRVSDAREHRQEGLGSLFYFTLDVLETGCHVLSRTSWKNCGVRIVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRMCPDCPSLSNPRYMETATESLAKYNSRSPSKQYSVVKITKTFSQWVFGPAYFVEYLIKESPCTKSQSSCALESPDSVPVGICHGSLGKTISVTCSFFNSQAPTPRGENAEEPQQQNTASTNSPAKAVLKGSVQYLPDWDK-KDPVETFPVQLDLTTNEPLDVSFLFLEPMKLVVLPSAECPGPAQPLILPP >XP_004038216.1 fetuin-B [Gorilla gorilla gorilla] MGLLLPLALCILVLCCGAMSPPQSALLSRGCNDSDVLAVAGFALRDINKDRKDGYVLRLNRVNDAQEYRQDGLGSLFYLALDVLETDCHVLSKKAGQDCGMRIVYGQCKAIFYMNNPSRVLYLAAYNCTLRPVSKTCPDCPSSSNRQVLEAATESLAKYNNENTSKQYSLFKVTRASSQWVVGPSYFVEYLIKESPCTKSQSSCSLQSSDSVPVGLCKGSL-KFVSVTCDFFELQAPATGSENSEESQQKNTPPTDSPSKAGPRGSVQYLPELDD-KGPQEAFPVHLDLTTNETLDISFLFLEPMKLVVLPTAECPGPAQPLVLPP >XP_005506654.1 fetuin-B [Columba livia] MVSLVLLLFGTQALCSWAAA-HAAAFLSSPCNTTAAEEAADLALRQINADRREGYVLRLYRIFSVQEHPQEISSSAFYLVLDVVDTECHVLSKKLWKNCKARPVYGQCKAIIYINQARNIAHLNNYECILQPVPPVCPDCPVPTEPKYLEAAVQSLAKFNEESEQAHYSVLNVTRASMQWVIGPAYFVEFLIQETSCSKNDSKCKPLSSELAQIGFCKGSVEQFVTISCEIYNLQDPATEEGKQQSHQQAF--PSESPYLEKTVGLVKILPASTEDKDGKPVLPEAVRSTSTQKTQVDKSDLTNPGPVILPSDSCPGEAKSILQPL >XP_005675217.2 PREDICTED: fetuin-B [Capra hircus] MSVLLLLVLCTLAMGCGAASPPQSPLLSLDCNSSYVLDIANDILQDINRDRKDGYMLSLNRVSDAREHRQEGLGSLFYFTLDVLETGCHVLSRTSWKNCGVRIVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRMCPDCPSLSNPRYMETATESLAKYNSRSPSKQYSVVKITKTFSQWVFGPAYFVEYLIKESPCTKSQSSCALESPDSVPVGICHGSLGKTISVTCSFFNSQAPTPRGENAEEPQQQNTASTNSPAKAVPKGSVQYLPDWDT-KDPVETFPVQLDLTTSEPLDVSFLFLEPMKLVVLPSAECPGPAQPLILPP >XP_006260829.1 PREDICTED: fetuin-B [Alligator mississippiensis] MALLILLFLGIQALCSQAFSTPVSPFLFPACNDSAVESAVDVALGQINTGRTEGYVLRLNRIFSVLEHPQETSGSVFYLILDVAETECHVLSRRLWKNCKTRPVFGQCRTTLYINNPKRIAHLHSYECTLRPVPTLCPDCPIPTEPKYLETAVVSLAKFNSESTEAHYSVLNVTKASMQWVVGPAYFVEFTIQETSCSRNESKCKPLPFEKAHTGFCKGSVHQFVNIDCEIYEPQVPAIEKQKEQKHQHRHPSPTEALYLEKTVGWVKVLPPQQEHIDGNPVLPEVGMPVPDEKILTEGPGLIKPGPVFLSSDMCPGEPTSFILNL >XP_020734453.1 fetuin-B [Odocoileus virginianus texanus] MSMLLLLALCTLATGCGASYPPQSPLLSLDCNSSYVLDIASDILQDINRDRNDGYVLSLNRVSDAREHRQGGLGSLLYFTLDVLETGCHVLSRTPWKNCGVRFVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRTCPDCPSLSNPKYMEAANESLAKHNSRSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCTKSQSSCALESPDSVPVGICHGSKGKLISVNCSFFNSQAPTPRGENAEEPQQRNTAPTNSPTKAVLKGSVQYLHDWGK-KEPVETVPVQLDLTTNEPLDVSFLFLEPMKLVVLPSAECPGPAQPRLLPP >XP_043329405.1 fetuin-B [Cervus canadensis] MSVLLLLVLCTLAMGCGASYPPQSPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGGLGSLLYFTLDVLETGCHVLSRTPWKNCGVRLVYGQCKAIFYINKEKRIFYLAAYNCTLRPVSRTCPDCPSLSNPRYMETATESLAKHNSGSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCTKSQSSCALESPDSVPVGICHGSMGKLISVNCSFFNSQAPTPRGENAEEPQQQNTAPTNSPTKAVLKGSVQYLPDWGK-KEPVETVPVQLDLTTNEHLDIPFLFLEPMQLVVLPSAECPGPAQPRLLPP >KAB0374112.1 hypothetical protein FD755_014368 [Muntiacus reevesi] MSVLLLLALCTLATGCGASYPPQSHLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREDRQRGLGSLLYFTLDVLETGCHVLSRTPWKDCGVRFVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRTCPDCPSLSNPRFMETATESLAKHNSNSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCNKSQSSCALESPDTVPVGICEGSMGKLISVKCNFFNSQAPTPRGENVEEPQQQNTAPTNSPTKAVLKGSVQFLPDWGK-KEPVETVPVQLDLTTNEPLDLSFLFLEPMKLVVLPSAECPGPAQPRLLPP >KAB0359886.1 hypothetical protein FD754_004042 [Muntiacus muntjak] MSVLLLLALCTLATGCGASYPPQSHRLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHKQGGLGSLLYFTLDVLETGCHVLSRTPWKDCGVRLVYGQCKAIFYINKEKRIFYLPAYNCTLRPVSRTCPDCPSLSNPRFMETATESLAKYNSNSPSKQYSLVKITKTFSQWVFGPAYFVEYLIKESPCNKSQSSCALESPDTVPVGICEGSMGKLISVKCIFFNSQAPTPRGENVEEPQQQNTAPTNSPTKAVLKGSVQFLPDWGK-KEPVETVPVQLDLTTNEPLDLSFLFLEPMKLVVLPSAECPGPAQPRLLPP >XP_006017188.1 fetuin-B [Alligator sinensis] MALLILLFLGIQALCSQAFSPPVSPFLFPACNDSAVESAVDVALGQINTGRTEGYMLRLNRIFSVLEHPQETSGSVFYLILDVAETECHVLSRRLWKNCKTRPVFGQCRATLYINNPKRIAHLHSYECTLRPVPTLCPDCPIPTEPKYLETAVVSLAKFNRESTEAHYSVLNVTKASMQWVVGPAYFVEFTIQETSCSRNESKCKPLPFEKAHTGFCKGSVHQFVNIDCEIYEPQVPAIEKQKEQKHQHRHPSPTEALYLEKTVGWVKVLPPQQEHIDGNPVLPEVGKPVPDEKILTEGPGLIKPGPVFLSSDTCPGEPTSFILNL >KAF4020911.1 hypothetical protein G4228_012704 [Cervus hanglu yarkandensis] MSVLLLLALCTLAMGCGASYPPQSPLLSLDCNSSYVLDIASDILQDINRDRQDGYVLSLNRVRDAREHRQGGLGSLLYFTLDVLETGCHVLSRTPWKNCGVRL----------------------------------------------------------------------------WVFGPAYFVEYLIKESPCTKSQSSCALESPDSV-----------------------APTPRGENAEEPQQQNTAPTNSPTKAVLKGSVQYLPDWGK-KEPVETVPVQLDLTTNEHLDIPFLFLEPMKLVVLPSAECPGPAQPRLLPP >XP_018119101.1 fetuin-B [Xenopus laevis] MIFPVLLLVCTQVLGAVAYSIRQ--SSAVACNDSVVEAAADLSLRQLNGIRRKGFVFALHRITDAKEEFNIENGTVYQLTLDVVETECHVLSRQLWKDCEPKKVSGQCKTEFHIHKPRRIAHLHTYNCTLRQGPQGCPGCPMLDDFRFLEVAKLSLKKYNSENNFNSYSLANITRGRIQVVAGQAYHVEFTVRESSCNKTKDQCEILGSEDAATGYCKSFAKKVQRVSCRIFNPEGTDAEQHSHDKHGKKH-----HKHKHGQKSSESHE-DHSRNPDPNAHTP--TGSISYED---------------FPSEHCPGQIKPPAVPE >XP_040205396.1 fetuin-B-like [Rana temporaria] MKVCVLLLLCVHVLCTRTRGPPE--LTSLACNDTQAEFAADLSLRQLNAHRKEGFSFGLKRISNVQEQYDEENGSVFYLTLDVLEADCHVLSRKLWKECQSKPVFGQCKVIYQLNKPKRIAHLHYYDCTMTPAARPCPGCHFLNDTNFVEVAKKSLLKFNSESNNSKYLLGNITKAASQVVAGTAYHVEYTVQESTCNKSASQCEPLDCEFAHTGYCKAWAKAVQTISCDIFEPEAAIVEEQNHKKHGHKH-----HKHDHDHSGSHEHEHEHDHEHGPKSESPKTKGTVTYDETSAASGAEDKKKSFIRASDQCPGQAKVEDIPI >XP_015826648.1 PREDICTED: kininogen-1-like [Nothobranchius furzeri] MKTCVLLLL---VLGC-VHGAPVTGLETGSCEDPSAVSAAHSALSKINLDRTEGYVFTLHRLSNVHLAKNGEVGVVYYLTLDVVETNCSVLSRKDWKDCETRSVYGQCKAAIYISKPHRVVRLYKYKCLVRPVPAICPDCPTQDNEEVKKTIANTLDKFNRESGLNNRALLQVTRATAGMAMGMYYHVEYTIQETTCNKSTDQCPMMGCEFAHKGFCKASLDPNYSVQCEIFEPEAANAEKVQHHDHIHDHMHPVGHDHKPGSAYKHGHAHSHDHGDHSGD-SPNHHHNYKHHTHEHDHEALDHDEPVTTPSSECVAPAPALVDKL >XP_004068158.1 fetuin-B-like [Oryzias latipes] MKICILGLL---VLGC-VHGAPVD-LKPQSCDDPHAVKAAHVALTKINMDRNNGYIFSLHRLSNVHHSMHGENGVVYYLTMDVVETNCSVLSGKDWKHCEARPVYGQCKAAIFINKVHRVDRLYKYDCVIKPVPSLCPDCPTADNEQVQKTLSLSLDKFNKESGLKNRDKLKITRARAGMAMQMYYIVEYTIQETTCAHNTEKCPLMTCEFAHKGFCKASLEQSINVECEIYESEASEGEKEEHHDHTYDHTHEEAHDHKPGSAYRHSHFHSHEHGNHTGD-FPNHHHDYKHHTHDHDHEALDHEGPMILPSHECKAPAVNLVDQL >XP_030289806.1 fetuin-B-like isoform X1 [Sparus aurata] MKHSVLLSL-LLALGCHVHGAPVDGMQQGSCEDAQAKGAAQQALNKINQDRQEGYVLGLHRLSNVHITKHDENGAVFYLTLDVVETNCSVLSRKDYKSCEARPVYGQCKAAIFINRVQRVVRLYKYDCVIRPVPATCPDCPSFDNAEVQKAVSLSLEKFNKESGLANHSLLKISRATMGMAMSMYYNAEYTIQETTCPKSTEKCPQMACEFAHKGLCRASLHTETSVQCEIYEPESPEAVRVAEANLSLQRTRASSIVETVCSRNTDASELSNCKPEDQFEIRPSVGNKDSSNAVEVECEAVVEETVVDQPASSCPSPHRGIVKLR
PhyML tree of selected proteins (XP_015826648_1_PREDICTED__kininogen_1_like__Nothobranchius_furzeri_:0.19870945,XP_004068158_1_fetuin_B_like__Oryzias_latipes_:0.24580349,(XP_030289806_1_fetuin_B_like_isoform_X1__Sparus_aurata_:0.5786517,(tr_E7FE90_E7FE90_DANRE_Fetuin_B_OS_Danio_rerio_OX_7955_GN_fetub_PE_1_SV_1:0.31946193,((((XP_006017188_1_fetuin_B__Alligator_sinensis_:0.0039686,XP_006260829_1_PREDICTED__fetuin_B__Alligator_mississippiensis_:0.01563667):0.2950865,(XP_005506654_1_fetuin_B__Columba_livia_:0.12447035,(XP_003209226_1_fetuin_B__Meleagris_gallopavo_:0.04621886,NP_001264337_1_fetuin_B_precursor__Gallus_gallus_:0.04465176):0.13312801):0.17105699):0.35670882,(((XP_002832807_1_fetuin_B_isoform_X1__Pongo_abelii_:0.02281636,(sp_Q9UGM5_FETUB_HUMAN_Fetuin_B_OS_Homo_sapiens_OX_9606_GN_FETUB_PE_1_SV_2:0.01288025,(XP_004038216_1_fetuin_B__Gorilla_gorilla_gorilla_:0.01292802,(XP_034813758_1_fetuin_B_isoform_X1__Pan_paniscus_:0.00637209,XP_001153966_1_fetuin_B__Pan_troglodytes_:0.00000001):0.01607141):0.00000001):0.00310259):0.1456369,((XP_535835_2_fetuin_B__Canis_lupus_familiaris_:0.09750211,XP_019695567_1_fetuin_B_isoform_X2__Felis_catus_:0.12097455):0.05949005,(XP_003132625_1_fetuin_B__Sus_scrofa_:0.28897542,(NP_001029390_1_fetuin_B_precursor__Bos_taurus_:0.04965318,((XP_020734453_1_fetuin_B__Odocoileus_virginianus_texanus_:0.03164989,((KAB0374112_1_hypothetical_protein_FD755_014368__Muntiacus_reevesi_:0.00927294,KAB0359886_1_hypothetical_protein_FD754_004042__Muntiacus_muntjak_:0.0138865):0.04131619,(XP_043329405_1_fetuin_B__Cervus_canadensis_:0.0087471,KAF4020911_1_hypothetical_protein_G4228_012704__Cervus_hanglu_yarkandensis_:0.00000001):0.01244637):0.00812273):0.06378973,(XP_004003110_1_fetuin_B__Ovis_aries_:0.00265682,XP_005675217_2_PREDICTED__fetuin_B__Capra_hircus_:0.01010047):0.01764274):0.00771147):0.14603367):0.06722882):0.0314172):0.01625616,(XP_008264796_1_PREDICTED__fetuin_B__Oryctolagus_cuniculus_:0.26764326,(NP_001296451_1_fetuin_B_isoform_1_precursor__Rattus_norvegicus_:0.11038534,NP_067539_1_fetuin_B_isoform_1_precursor__Mus_musculus_:0.06976437):0.16690827):0.0137683):0.65357304):0.28751837,(XP_040205396_1_fetuin_B_like__Rana_temporaria_:0.3495951,XP_018119101_1_fetuin_B__Xenopus_laevis_:0.60546334):0.2729583):0.60059765):0.16237735):0.10862626);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)