PB0080

DATABASE

Click here to access PB0080 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0080	P01031	Complement C5	C5	C5D, C5a, C5b, CPAMD4, ECLZB	Homo_sapiens	C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

Domains

Gene Ontology

PF00207 (A2M) PF01759 (NTR) PF01821 (ANATO) PF01835 (MG2) PF07677 (A2M_recep) PF07678 (TED_complement) PF07703 (A2M_BRD) PF17789 (MG4) PF17790 (MG1) PF17791 (MG3)

GO:0004866 (enables) endopeptidase inhibitor activity GO:0005102 (enables) signaling receptor binding GO:0005515 (enables) protein binding GO:0008009 (enables) chemokine activity GO:0001701 (involved in) in utero embryonic development GO:0002376 (involved in) immune system process GO:0006935 (involved in) chemotaxis GO:0006954 (involved in) inflammatory response GO:0006956 (involved in) complement activation GO:0006957 (involved in) complement activation, alternative pathway GO:0006958 (involved in) complement activation, classical pathway GO:0007166 (involved in) cell surface receptor signaling pathway GO:0007186 (involved in) G protein-coupled receptor signaling pathway GO:0010575 (involved in) positive regulation of vascular endothelial growth factor production GO:0010760 (involved in) negative regulation of macrophage chemotaxis GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0019835 (involved in) cytolysis GO:0032722 (involved in) positive regulation of chemokine production GO:0045087 (involved in) innate immune response GO:0045766 (involved in) positive regulation of angiogenesis GO:0060326 (involved in) cell chemotaxis GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0070062 (located in) extracellular exosome GO:0005579 (part of) membrane attack complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P01031|CO5_HUMAN Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYP DKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPIT YDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI GIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGY KNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVT FDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATP LFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASF VLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGE HLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRL LVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWV ALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANAD DSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISL GPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLV PRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQ LKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTV LPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFP YRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFY VFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTA FALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEAREN SLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDK THPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLN LKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHK GALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLK IDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLK ALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHR PDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYA YKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIM GKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC >tr|E7FCV2|E7FCV2_DANRE Complement component 5 OS=Danio rerio OX=7955 GN=c5 PE=1 SV=2 MARLLLFCIFNLFVCFTVQENVYLITAPKVLRLDASETVVVQLFGFDQETTVHLHLKNTL AVGNKEYDYQSLKLNAANNYQASATLRILAKDFPKEDTSVYLQTISSAFTDNVKIPVTTV NGFLFIQTDKPLYTPEQEVQVRVYSLNEELRKSARTVTLTFQDPRGVKVEIIDMTDINGA KPLLPPFKIPLKPIYGIWKIVATYADNFETTATAEFEVKEYVLPSISVQIEPETNYISEE NFDTFKLKISAKYVQGMPVKSANILLKFGYSTPEETVIIPSTYRSYMLYNGKMEVDLDIR SALSSKPDAPQFLNAMKENTFLYVEVLLQESTGGLSQEAVLSHVKFVETPFTLSIIATPP FIKPGLPYAMRVLVKDPLGEPVKDVSVTMRATATTVDNLSDNLKFLGHQDSVTVPSSKDG VAYFTCNIPANVKNAEFTFETEDASWSQGPLTLKAESYVSVNHRYLYIDLPPESSVFEVG QYVDISVVFSYRDYLSLDTFSYQIISKGKVVKYDTVKRVSEKSQSLNIKITPDMVPSARL LVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTLKLQDDYKPKDKLEIKVSSRSKG ESLVAFSAVDTALFNLRTNKKDPLKKILQHVEKSDLGCGKGGGKNNADVFDRAGLMFITN ANAKASSAGGTCSDTLRPKRSVDLKKKFEDKAQKYGAFREYCLSGTRSSPTLETCKDRAN RVTLPNKKTRRDYEKEKYCRLAFEQCCVFAKDLRKENAENIILSRAAIDFLMDAPLSQVR SYFPESWLWEEHLSKSGSVSISKTLPDSITTWELKAVGVFNEGICVSDKRIPVSQDIWVD VPLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLTASSAVCVFHGAQQGKPDKTNENSGQV AGGSVAMVSFYIMALEAGTHTLTFTLTTDWITESVVKKLRVVPEGIRMEEYIGKRIDPNG VFGTPMRKLEFKNVIPPKIVPKSSVDRIITVNGEVLGDILSILNNPEGIKMLTNLPRGSA ELELMSLLPVYYVYHYLDKTEKWNILGKEAAASEKELKRKMQAGITSIMSFQLKNGEAFS MWAQKDKTPSTWVTALIIKTLSDIHEYVYVDTDVLANAIHWLIKNCQNEDGSFSELAKTN PHKLMGAGVGVTEKSVYLTSYVMIGIKNALKIPNLKLQVFKDALDRGMQYLISRFRKSSH KIESLYVRAIASYAMTVADIDDGTAVNVYENIKKKAKIDGNPPRVCFWQESDTNIDPLKP SSVTAKSVETTVYVLLNTLTRGETEYAKPILNWLTQDQRYGGGVYSTQDTILTLEALTMY SIKAREANLNMVVDIEYKTRGERISRIQLTQQKPVAKPIEVTQNDDVIVKTAMSTGVSFV KLKTVYYVMTESNKSCLFDTTIDIHDSDQNSDDPMLLSQRIVACAKFKPPENSLETESAL TVMEINLPTGVTPVLEDLDEYQNGLESRISNYEVIGDKVVLQIDSIPSDNFYCVGFRILE EFETGMTKASEFTVYEYQAPAFKCTKLYQKQTRKLLRLCEEDHCQCMAAECCNFKSTIDP AITADQRTADICKESVKYALKVVIDSSEAGGDFVTYKATVQSVLKKGETDDLKTDSEVEF IKKASCNSTQFEIGKQYLTMTAESMKIQVNRAYKYKFPLDSEAWVDWWPLESDCSDANCK QYVKVLEGFEFEYLLNGCDLMSSR
Selected proteins from model organisms >sp|P01031|CO5_HUMAN Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYP DKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKRMPIT YDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHI GIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGY KNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQVT FDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATP LFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASF VLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGE HLNIIVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRL LVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWV ALAAVDSAVYGVQRGAKKPLERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANAD DSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKCCYDGACVNNDETCEQRAARISL GPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLV PRRKQLQFALPDSLTTWEIQGVGISNTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQ LKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTV LPLEIGLHNINFSLETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFP YRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFY VFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTA FALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEAREN SLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYALSLGDK THPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLN LKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHK GALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLK IDTQDIEASHYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLK ALVEGVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHR PDKQCTMFYSTSNIKIQKVCEGAACKCVEADCGQMQEELDLTISAETRKQTACKPEIAYA YKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCTNAELVKGRQYLIM GKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC >tr|E7FCV2|E7FCV2_DANRE Complement component 5 OS=Danio rerio OX=7955 GN=c5 PE=1 SV=2 MARLLLFCIFNLFVCFTVQENVYLITAPKVLRLDASETVVVQLFGFDQETTVHLHLKNTL AVGNKEYDYQSLKLNAANNYQASATLRILAKDFPKEDTSVYLQTISSAFTDNVKIPVTTV NGFLFIQTDKPLYTPEQEVQVRVYSLNEELRKSARTVTLTFQDPRGVKVEIIDMTDINGA KPLLPPFKIPLKPIYGIWKIVATYADNFETTATAEFEVKEYVLPSISVQIEPETNYISEE NFDTFKLKISAKYVQGMPVKSANILLKFGYSTPEETVIIPSTYRSYMLYNGKMEVDLDIR SALSSKPDAPQFLNAMKENTFLYVEVLLQESTGGLSQEAVLSHVKFVETPFTLSIIATPP FIKPGLPYAMRVLVKDPLGEPVKDVSVTMRATATTVDNLSDNLKFLGHQDSVTVPSSKDG VAYFTCNIPANVKNAEFTFETEDASWSQGPLTLKAESYVSVNHRYLYIDLPPESSVFEVG QYVDISVVFSYRDYLSLDTFSYQIISKGKVVKYDTVKRVSEKSQSLNIKITPDMVPSARL LVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTLKLQDDYKPKDKLEIKVSSRSKG ESLVAFSAVDTALFNLRTNKKDPLKKILQHVEKSDLGCGKGGGKNNADVFDRAGLMFITN ANAKASSAGGTCSDTLRPKRSVDLKKKFEDKAQKYGAFREYCLSGTRSSPTLETCKDRAN RVTLPNKKTRRDYEKEKYCRLAFEQCCVFAKDLRKENAENIILSRAAIDFLMDAPLSQVR SYFPESWLWEEHLSKSGSVSISKTLPDSITTWELKAVGVFNEGICVSDKRIPVSQDIWVD VPLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLTASSAVCVFHGAQQGKPDKTNENSGQV AGGSVAMVSFYIMALEAGTHTLTFTLTTDWITESVVKKLRVVPEGIRMEEYIGKRIDPNG VFGTPMRKLEFKNVIPPKIVPKSSVDRIITVNGEVLGDILSILNNPEGIKMLTNLPRGSA ELELMSLLPVYYVYHYLDKTEKWNILGKEAAASEKELKRKMQAGITSIMSFQLKNGEAFS MWAQKDKTPSTWVTALIIKTLSDIHEYVYVDTDVLANAIHWLIKNCQNEDGSFSELAKTN PHKLMGAGVGVTEKSVYLTSYVMIGIKNALKIPNLKLQVFKDALDRGMQYLISRFRKSSH KIESLYVRAIASYAMTVADIDDGTAVNVYENIKKKAKIDGNPPRVCFWQESDTNIDPLKP SSVTAKSVETTVYVLLNTLTRGETEYAKPILNWLTQDQRYGGGVYSTQDTILTLEALTMY SIKAREANLNMVVDIEYKTRGERISRIQLTQQKPVAKPIEVTQNDDVIVKTAMSTGVSFV KLKTVYYVMTESNKSCLFDTTIDIHDSDQNSDDPMLLSQRIVACAKFKPPENSLETESAL TVMEINLPTGVTPVLEDLDEYQNGLESRISNYEVIGDKVVLQIDSIPSDNFYCVGFRILE EFETGMTKASEFTVYEYQAPAFKCTKLYQKQTRKLLRLCEEDHCQCMAAECCNFKSTIDP AITADQRTADICKESVKYALKVVIDSSEAGGDFVTYKATVQSVLKKGETDDLKTDSEVEF IKKASCNSTQFEIGKQYLTMTAESMKIQVNRAYKYKFPLDSEAWVDWWPLESDCSDANCK QYVKVLEGFEFEYLLNGCDLMSSR >NP_034536.3 complement C5 preproprotein [Mus musculus] MGLWGILCLLIFLDKTWGQEQTYVISAPKILRVGSSENVVIQVHGYTEAFDATLSLKSYPDKKVTFSSGY VNLSPENKFQNAALLTLQPNQVPREESPVSHVYLEVVSKHFSKSKKIPITYNNGILFIHTDKPVYTPDQS VKIRVYSLGDDLKPAKRETVLTFIDPEGSEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKANYKKDFT TTGTAYFEIKEYVLPRFSVSIELERTFIGYKNFKNFEITVKARYFYNKVVPDAEVYAFFGLREDIKDEEK QMMHKATQAAKLVDGVAQISFDSETAVKELSYNSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLS PYTLNLVATPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMAQTVDVNQETSDLETKRSITHDTDGVAVF VLNLPSNVTVLKFEIRTDDPELPEENQASKEYEAVAYSSLSQSYIYIAWTENYKPMLVGEYLNIMVTPKS PYIDKITHYNYLILSKGKIVQYGTREKLFSSTYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVW INIEEKCGNQLQVHLSPDEYVYSPGQTVSLDMVTEADSWVALSAVDRAVYKVQGNAKRAMQRVFQALDEK SDLGCGAGGGHDNADVFHLAGLTFLTNANADDSHYRDDSCKEILRSKRNLHLLRQKIEEQAAKYKHSVPK KCCYDGARVNFYETCEERVARVTIGPLCIRAFNECCTIANKIRKESPHKPVQLGRIHIKTLLPVMKADIR SYFPESWLWEIHRVPKRKQLQVTLPDSLTTWEIQGIGISDNGICVADTLKAKVFKEVFLEMNIPYSVVRG EQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSAASLHTSRPSRCVFQRIEGSSSHLVTFTLLPLEIG LHSINFSLETSFGKDILVKTLRVVPEGVKRESYAGVILDPKGIRGIVNRRKEFPYRIPLDLVPKTKVERI LSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNHWNIFYPDTLSKRQSLE KKIKQGVVSVMSYRNADYSYSMWKGASASTWLTAFALRVLGQVAKYVKQDENSICNSLLWLVEKCQLENG SFKENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDICPTMKIHTALDKADSFLLENTLPSKSTF TLAIVAYALSLGDRTHPRFRLIVSALRKEAFVKGDPPIYRYWRDTLKRPDSSVPSSGTAGMVETTAYALL ASLKLKDMNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLKQIHLDMDINVAYKHEGDFHKY KVTEKHFLGRPVEVSLNDDLVVSTGYSSGLATVYVKTVVHKISVSEEFCSFYLKIDTQDIEASSHFRLSD SGFKRIIACASYKPSKEESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQLLTDYQIKDGHVILQLNS IPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSISDTRLQKVCEGAACTCVEADCAQLQ AEVDLAISADSRKEKACKPETAYAYKVRITSATEENVFVKYTATLLVTYKTGEAADENSEVTFIKKMSCT NANLVKGKQYLIMGKEVLQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVENLNNFAEDLFLNSCE >NP_444179.1 complement C5 precursor [Rattus norvegicus] MPLPAMGLWGLLCLLIFLDKTWGQEQTYVISAPKIFRVGSSENVVIQAHGYTEAFDATISLKSYPDKKVT YSSGYVNLSPENKFQNSALLTLPPKQFPRDENPVSHVYLEVVSMHFSKSKKIPITYDNGFLFIHTDKPVY TPDQSVKIRVYSLSDDLKPAKRETVLTFVDPEGTEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIKAKY KKDFTTTGTAYFEVKEYVLPRFSVSIEPESNFIGYKNFKNFEITVKARYFYNKMVPDAEVYIFFGLREDI KEDEKQMMHKAMQAATLVNGVAQISFDSETAVKELSYESLEDLNNKYLYIAVTVTESSGGFSEEAEIPGI KYVLSPYTLNLVATPLFLKPGIPFSIKVQVKDSLEQLVGGVPVTLMAQTVNVNQETSDLEPKRSITHSAD GVASFVVNLPSEVTSLKFEVKTDAPELPEENQASKEYEAVTYSSLSQSYIYIGWTENYKPMLVGEYLNII VTPKSPYIDKITHYNYLILSKGKIVQYGTKEKLLYSSYQNINIPVTQDMVPSARLLVYYIVTGEQTAELV ADAVWINIEEKCGNQLQVHLSPDKDVYSPGQTVSLDMVTEADSWVALSAVDSAVYGVRGKAKRAMQRVFQ AFDDKSDLGCGAGGGRDNVDVFHLAGLTFLTNANADDSQYHDDSCKEILRPKRDLQLLHQKVEEQAAKYK HRVPKKCCYDGARENKYETCEQRVARVTIGPHCIRAFNECCTIADKIRKESHHKGMLLGRIQIKALLPVM KAEIRSYFPESWLWEVHRVPKRNQLQVALPDSLTTWEIQGIGISDNGICVADTLKAKVFKDVFLEMNIPY SVVRGEQIQLKGTVYNYRTSGTMFCVKMSAVEGICTPGSSAASPQTSRSSRCVRQRIEGSSSHLVTFSLL PLEIGLHSINFSLETSFGKEILVKTLRVVPEGIKRESYAGVTLDPRGVYGIVNRRKEFPYRIPLDLVPKT NVKRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWNIFHPDTLAR KQSLQKKIKEGLVSVMSYRNADYSYSMWKGASSSAWLTAFALRVLGQVNKYVKQDQYSICNSLLWLIEKC QLENGSFKENSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGICPTEKIYTALAKADSFLLERTLP SKSTFTLAIVAYALSLGDRTHPKFRSIVSALKREALVKGDPPIYRFWRDTLQRPDSSAPNSGTAGMVETT AYALLTSLNLKETSYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLHLDMDINVSYKHKG DFYQYKVTEKNFLGRPVEVPLNDDLIVTTGYSSGLATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSY LSYSDSGHKRIIACASYKPSKEESASGSSHAVMDILLPTGIGANQEDLRALVEGVDQLLTDYQIKDSHVI LQLNSIPSRDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACKCVEAD CGQLQAELDLAISADTRKETACKPEIAYAYKVRITSATEENIFVKYTATLLDIYKTGEAAAEKDSEITFI KKISCTNANLVKGKQYLIMGKEALQIKHNFSFKYIYPLDSSTWIEYWPTDTTCPSCQAFVANLDEFAEDI FLNGCENA >NP_001001646.1 complement C5a anaphylatoxin precursor [Sus scrofa] MGLWGILCFLIFLGKTWGQEQTYVISAPKILHVGAAENIVVQVYGYTEAFAVTVSVKSYPDKKITYSSMY VILSTENKFQNSAFLTIQPKQLLGKPNSVSHVYLDIVSKHFSRSKKIPVTYDNGFLFIHTDKPVYTPHQS VKVRVYSLNDELKPAKRETVLTFIDPQGSEVEVLEENDYTGIISFPDFKIPSNPKYGVWTIQAKYREDFS TTGTAYFEIKEYVLPHFSVSIEPENNFIGYKDFNDFEITVKARYFYNKVVSEADVYMFFGIREDLKDEQK VMMQKAMRNTMLINGIAKVTFNSETAIKELSYDSLEDLNNKYLYIGVTVIESTGGFSEEAEIPGIKYVLS PYKLNLVATPLFVKPGIPYSIKVQVKDSLDLLVGGVPVILSAQTLDANQETSDLESKKSVTRSRDGVASF VVNLPAGVTVLEFNIRTEDPDLSDENQARANYRAIAYSSLSQSYLYIEWTQNYKPVLVGEHLNVVVTPKS PYIDKITHYNYLILSRGKIVHFGTREKLSNSAYQSINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLQVHLSPNTDTYSPGQHVSLNLVTELDSWVALSAVDKAIYGVQMTAKKPLERVFQTFEKN DLGCGAGGGRNNADVFHLAGLTFLTNANTDDIRENDEPCKDILRPKRMLQKKIEEEAAKYKYAMLKKCCY DGAYRNDDETCEERAARIKIGPKCVKAFKDCCYIANQVRAEESHKNIQLGRLHIKTLLAVTNPEIRSYFP ESWLWEVHHVPRRNQLQFVLPDSLTTWEIQGIGISNSGICVTDTLNAKVLKDVFLEMSIPYSVVRGEQIQ LKGTVYNYGTSGVLFCVKMPPVEGICSSGSPGIDPQGKKSSRCQPQKIEGSSSHLVTFDVLPLEIGLHNI NFSLETSLGREILVKTLRVVPEGVKRESYAGITLDPRGIYGAMTRRKEFPYRVPLDLVPKTKVKRIVSVK GLLIGEVMSAVLSQEGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGNNWNIFSSNSLAQRQNLQKKLR EGVVSVMSFRNADHSYSMWKSGSASTWLTAFALRVLGQASKYIDQDLNSICNSILWLVEKCQLGNGSFKE NSEYQPIKLQGTLPIEAQENTLYLTAFAVIGIRKAFDLCPLMKISMALTKADTFLLENTRSTRSTFALAI AAYALSLGDKSHPQFRSIVSALKKEALVKGNPPIYRFWKDDLQKKDRSVPNTGTARMVETTAYALLTSLN LKDMNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIKNFLLNMDVKVSYKHRGDFYHYKITE KNFIGRPVEVPLNDDLVVFSTGQNSGLATVHVKTVVHKTSTSEEVCSFDLKIEIQDIEASSYSSSEYKRI VACASYKPSREESSSGSSHAVMDISLPTGVNANAEDLRALVEGVDQLLTDYEIKDGHVICQLNSIPSNNF LCVRFRIVELFQVGFLSPATFTVYEYHRPDKQCTMFYSMSQTKLQKVCEGVTCKCVEADRGQMQTEVDLT ISVNTRKETACKPEIAYVYKVKIIAMTEESAFVKYTASLLDVYKAGEAVAEKGSEITFIKKTTCTNANLE KGKQYLIMGKEALQIKHNFNFKYIYPLDSSTWIEYWPTDTACPSCQTFLANLDEFTEDIFLNNCENA >XP_415405.5 complement C5 isoform X1 [Gallus gallus] MAILMYFFVLVFSGTAFSQDKTYVLTAPKVFRVGTSEKVVVQAFGYEKEFAVNLALRSFPDKLVAYSSGH ISLNPDNNFQSSVTVTLQPTDLAGPEDSVKYVYLEAVSPHFTGLKKVPVSYENGFLFVHTDKPIYTPDQS VKVRVYSLNEELQPARRETVLTVVDPDGVKVDIIEENDFTGIVSFPDFKIPPNPKYGIWKIEAKYKKNFI TSAVAKFEVKEYAMPSFSIVIEPENNFISSDKFENFRIAVKASYFYNKRLAKADVFLRFGIIEGTEKRMM PRAMLVAKLTNGVAEINFNSKKAVSSLGFQSLEELDGSYLYIAASVVESMGGLSGEVEFSEVKYAVSPYT LSLIATPLFIKPGLPFFIKVQVKDTVDRFVGNIPLVITAKSFSQQMDETELISEGSESGRRETSINDGTA LFVVNVPTDSNLLEFQVKTADPHLSDENQATKTYEARVYSSLSQSYLYIDWASNHKILSVGDFISINIYP RSRYIHNIHHYSYLITSKGKIVSFGTQKRIKDLEYEHLSFQITQEMVPSARLIVYYIVGEEPAELVADSV WLNVEQKCGSSLDIKLLSSKETHKPAEIVSLNMKTQFDSFVALSSIDKAIYGVTGRGKRAMEKIMLKLEK SDLGCGAGGGQNNVDVFRMAGLTFLTNANADDSNEAGGKCSEVIRTKRSDFEEQVLKEASKYKHLEIRKC CMHGVKAYPVSETCSDRARRIQSHAKCVSAFRHCCEFANRLREEEPSKLLILARKQFEAFLELDEAEVRS YFPESWLWEVHQVSPRSKTLSITLPDSLTTWEVQGVGISDKGICVAAPLEVQVVKDIFLSIYVPYSVVRG EQIELKGSVYNHRASAIKFCVKIAAGDGICSSGDSATTRQRMHNCNLKNLGAGSSSPIVFRILPLELGLH TINFTLLTTGSSETVVKTLRVMPEGIKKELHAGFTLDPQGVYGSIKRRQEFRYKIPLNLVPKTKIDRSVS VKGHLMGEVIATILSPEGLSILTNLPKGSAEAELMTIAPVFYVFHYLEASNNWHILGPETLTSRTAMRRK MKEGIVSVLSFRNSDFSYSMWKNGKASTWLTAFALRILGQVNQYINLDQISVCNSLLWLIDNCQMPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSIIGIEKSIKICPTQKIHDAKNKAGDYLLTNVQSAQSPFTM AIISYALALVDLNHQAARSLFSALKREASVIGDPPIYRFWKDDFKTSDLLAPSPVTAQMVETTAYALLTA LLRGDKNYANPIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVKRLHLDMGIKVAYRNHGDLHLFKL TEDNFVGRSVTVPLDDDIYVSTGSSTGIATVNVRTVYNVMGTSEESCNFELKIVPKRDDGYRGEDGGPLG RLEACAKYRPSRREPQSGSAHVVMDISLVSGLEANSEDLSTLASGVDQLIADYEIKDGHVILQIDSVPAD RFLCVGFRISQLFHVGMLNPGTFSVYEYHAPDKRCTVFYNPYGNEKLVRLCEGDECKCMEAECSKVQERL DQSITADTRREVACQNDIAYVYKVNILSRSEEGYFVKYSATILDLYKRGQAFAQKNNEVTFVKKKTCANV ELSPGMQYLIMGKEALKINIGYSFRFQYPLDSSTWIEWWPPNTACTFCQEFLNRMEDFVEDLIISGC >XP_016817059.1 complement C5 isoform X1 [Pan troglodytes] MPGSLGREASGRAGSTGCGAFAFGLRCRYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKF SYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKKMPITYDNGFLFIHTDKPV YTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAK YKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIRED LKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPG IKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVD DGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNI IVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAEL VSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVF QFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRMLQKKIGEIAAKYKHSV VKKCCYDGACVNNDETCEQRAARISLGLRCVKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE IRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVAISNNGICVADTVKAKVFKDVFLEMNIPYSVV RGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLG IGLHNINFSLETSFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIK RILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQK LKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLD NGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQS TFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYA LLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALH NYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGY GNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQL NSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGATCKCVEADCGQ MQEELDLTISTETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKV TCSNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLN GC >XP_038512006.1 complement C5 isoform X1 [Canis lupus familiaris] MGLWGILWFLIFLGKSWGQEQTYVISAPKVFRVGASENVVIQVYGYTEEFDATISIKSYPDRKFSYSSGY VTLSPENKFQNNVVLTIQPKQLSGGQGPVSHVYLEVVSRHFSKSKKVPITYDNGFLFIHTDKPIYTPQQS VKVRVYSLNDDLKPAKRETVLTYIDPEGSEVDIVEENDYTGIISFPDFKIPSNPKYGVWTIRAKYKEDFS TTGTTQFEVKEYVMPHFTISIEPEKSFIGYKDFNNFEITIKARYFYNKVVTEAEVYISFGIRDDLKSDQK EMMQKAMRDTMLINGVAQVTFNSETAIKELSYSSLEDLNDKYLYIGVTVIESTGGFSEEAEIPGIKYILS PYKLNLVATPLFLKPGIPYSIKVQVKDVLDQLVGEVPVTLSAHSVNVNQEVSDLESKKSVTRSSDGVASF VVNLPSGATVLEFNVKTADPDLPEENQASKDYQAIAYSSLSQSYLYIDWTENYKPFLVGEHLNIIVTPRS PYIDNITNYNYLVLSKGKIVHFGKAEKLPDSSYQSVNIPVTPDMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLQVHLSPSANSYYPGQSVSLNMVTESSSWVALSAVDSAIYGVQGQAKKPMQRVFQALETS DLGCGAGGGRNNAEVFYLAGLTFLTNANADDTQEDDKPCKEILRPRRMLRKKIEEEAAKYKQAVLKKCCY DGANRNYDETCEQRAARIKVGPWCAKAFRACCDIASQHRTDSNKPLQLGRLQIKHLLPVTKPEIRSYFPE SWLWEVHHVSGRRNQLQFGLPDSLTTWEIQGVGISDSGICVADTLKVQVFKDIFLEMNIPYSVVRGEQIE LKGTVYNYRRFGIRFCVQMSAAEGICTAGGSAGDRRGPDPSKCRSLRLEGSSSHLVTFSVLPLEIGLHNI NFSLETSLGREILVKTLRVVPEGIKKESYAGVTLDPRGIYGVISRRKEFPYRIPLDLVPKTEVKRIVSVK GMLMGEVMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVFHYLEAGSNWNIFSPNSLMKKQSLKNQLK QGMVSITSYRNADYSYSMWKGGDASTWLTAFALRVLGQVQKYIGQNQNSICNTLLWLTENCQLENGSFKE NSQYQPVKLQGTLPTEAHEHSLYLTAFAVIGIRKAFDLCPLQKINAALTRADAFLLEGAPSARSTFTLAI AAYALSLGDRTHPQFYSIVSGLKRKALVKGDPVIYRFWKDDHQEQERSTATAGTARTVETTAYALLTCLS LGDVAYVNPVVRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIKQLHLNMDVKISYKHKGDLYHYKMTE KNFLGRPIEVPLNDDLVVSTGFSNGLATVHVTTVVQKTSTSEEVCSFDLKIDTQDIEASSFRGYSDSDYK RIIACASYKPSKEESSSGSSHAVMDISLPTGVSANIEDLRALVEGVDQLLTDYQIKDGHVILQLDSIPSD EFLCVRFRIFELFQVGFLSPATFTVYEYHRPDKQCTMFYSPSGSKLQKVCEGVTCKCVEADCGQMQAELD LTISADARKETACKPDIAYAYKVHITSITKENVFIKYTATLLDVYKAGEAAAQKDSEITFIKKATCANAE LEKGRHYLIMGKEALQIKHNFSFKYIYPLDSSTWIEYWPTADAACPACPAFLANLDEFAEDIFLNGCENS >NP_001160088.1 complement C5a anaphylatoxin precursor [Bos taurus] MGLWGILCFLIFLGKSWGQEQTYVISAPKVFHVGAYENVVIQAYGYTEEFDATVSIKSFPDKKVTYSSGH VTLSAENKFQNSATLTIQPKQLSERQSSVSHVYLEVTSKHFSKAKKMPVTYDNGFLFIHTDKPVYTPHQS VKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEENDYTGIISFPDFKIPSNPKYGVWTIRAKYKEDFS TTGTAYFEIKEYVLPHFSISIEPKSNFIGYKDFTNFEITIRARYFYNKVVNEADVYITFGIRDNLEDNQK EMMQKAMQSTALINGMAQVTFNSETAVKELSYESLEDLNNKYLYIGVTIIESTGGFSEEAEIPGIKYVLS PYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSAKTLDANQEITDLESKKSVTRSSDGVASF VVNLPSEVTVLEFNIKTEDLDLPEENQASEDYRAVAYSSLSQSYLYIDWTENYKHLLVGAHLNIVVTPRS PYIDKITHYNFLILSKGKIVHFGTRDKLSDSAYQSINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLEVHLSPETDAYSPGQRVSLNMETELDSWVALTAVDSAIYGVQRTAKRPLERVFQTLEKG DLGCGAGGGRDNAEVFYLAGLTFLTNANADDTRENDEPCKEILRPKRMLKKKIEEEAAKYRNAWVKKCCY DGAHRNDDETCEQRAARIQAGPICIKAFKSCCAIASQFRADEHHKNMQLGRLHIKSLLPVTKPEIRSYFP ESWLWEVHRVPKRNQLQFVLPDSLTTWEIQGVGISNSGICVADTLKAKVFKSVFLEMNIPYSVVRGEQVQ LSGTVYNYRTSGIQFCVKMHPVEGICSSGTPVTDSQGRRFSKCVLQKIEGSSNHLVTFTVLPLEVGLHNL SFSLETSVGNEILVKTLRVVPEGVKRESYAGVTLDPQGVYGIISRRKEFPYRIPLNMVPKTKVKRTVSIK GLLIGEIMSAVLSQEGIDSLTRLPKGNAEAELMSVVPVFYVYHYLEAGHNWDIFSTNSLTQKQNLKTKLK EGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYVDQNQNSICNSLLWLLEKCQLENGSFKE NSDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKAFDICPLEKISTAVSKADIFLHENALSSQSAFTLAI AAYALSLGDKAHPQFRAIVSALKRKAFVKGNPPIYRFWKDDLQQRDSFVPNTGTARMVETTAYALLTNLN LKDMNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVRKLRLNMDVKVSYKNKGDLYHYKMSD KYFLGRPIEVPLNDDLVVLSTGQSSGLATVHVKTVVHKISTSEEVCSFHLKIETREIEAFGYSSSEYKRI VACASYKLSSEESSSGSSHAVMDISLPTGVNANPEDLKALVEQVDQLLTDYEIKDGHVILQLNSIPSNEF LCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNTKLQKVCEGVTCKCIEADCGQMQAELDLT ISAATRKETACKPEIAYAYKVEIVAVTEENAFVKYTATLLDIYKAGEAAAERDAEITFIKKTSCSNANLE KRKQYLIMGKEALQIKHNFRFKYVYPLDSSTWIEYWPTDSRCPSCQRFLANLDEFTEDIFLNGCENA >XP_024108622.1 complement C5 [Pongo abelii] MRGSLGREASGRAGPTGCGAFAFGLRCRYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKF SYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKKMPVTYDNGFLFIHTDKPV YTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAK YKEDFSTTGTTYFEVKEYVLPHFSVSIEPECNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIRED LKDDQKEMMQTAMQNTMLINGIAQITFDSETAVKELSYYSLEDVNNKYLYVAVTVIESTGGFSEEAEIPG IKYVLSPYKLNLVATPLFLKPGIPYSIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSITRVD DGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREDYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNI IVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAEL VSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRRAKKPLERVF QFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSV VKKCCYDGARVNNDETCEQRAARISIGPRCVKAFTECCVVASQLRANNSHKDMQLGRLHMKTLLPVSKPE IRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNSGICVADTVKAKVFKDVFVEMNIPYSVV RGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPAIDHQGTKSSKCVHRKVEGSSSHLVTFTVLPLE IGLHNISFSLETSFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIK RILSVKGLLVGEILSAVLSQEGINILTHLPRGSAEAELMSIVPVFYVFHYLETGNHWNIFHSDTLIEKQK LKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLD NGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLAKIDTALIKADNFLLENTLPAQS TFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDDLQHKDSSVPNTGTAHMVETTAYA LLASLNLKDINYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLNMDIDVSYKHKGALH NYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDPQDIEASHYRGY GNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGIGANEEDLKALVEGVDQLFTDYQIKDGHVILQL NSIPSRDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAVCKCVEADCGQ MQKELDLAISAETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKV TCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLN GC >XP_003207914.2 complement C5 [Meleagris gallopavo] MAILIYFFVLVFSGTAFGQEKTYVLTAPKVFRVGTTEKVVVQAFGYENEFAVSLALRSFPDKIVVYSSGH ISLNPENNFQNSVTVTLQPTDLAGPEDSVKYVYLEAVSPHFTGLKKIPVSYENGFLFIHTDKPIYTPDQS VKVRVYSLNEELQPARRETVLTIVDPDGVKVDIIQENDFTGIVSFPDFKIPPNPKYGIWKIEAKYKKNFI TSAVAKFEVKEYAMPSFSIVIEPEHNFISSDKFENFRIAVKASYFYNKRLAKADVFLRFGIIEGTERRMM PRAMLVTKITNGVAEINFNSKKAVSSLEFQSLEELDGSFLYIAASVAESMGGLSGEVEFSGVKYAVSPYT LSLIATPLFIKPGLPFFIKVQVKDTVDHFVGNIPLIITAKSFSQQMDATELISEGSESGRRETSINDGTA LFVVNIPPDSNLLEFQVKTADPHLSDENQATKTYEARVYSSLSQSYLYIDWASNHKVLNVGDFISINVYP RSRYIHNIHHYSYLITSKGKIVSFGTQKRIKDLEYEHLSFQITQEMVPSARLIVYYIVGEEPAELVADSV WLNVEQKCGSSLDIKLLSSKETHKPAEVVSLNMKTQFDSYVALSSVDKAIYGVTGRGKGAMKKIMLKLEK SDLGCGAGGGQNNVDVFRMAGLTFLTNANADDSNEAGEKCSEVIRTKRSDFEERVLKEASKYKHLEIRKC CMHGVKVYPVSETCSDRARRIQSHPKCISAFINCCEFANRLREEEPNKLLILARKQFEALLELDETEVRS YFPESWLWEVHQVSPRSKTLSVTLPDSLTTWEVQGVGISDRGICVAAPLEVQVVKDIFLSIYVPYSVVRG EQIELKGSVYNHRASAIKFCVKIAVGDGICSSGGSATTGARMHNCDFKNLDAGSSSPIMFRILPLELGLH TINFTLLTTGSSETVVKTLRVKPEGIKKELHAGFTLDPQGVYGSIKRRQEFRYKIPLNLVPKTKIDRSVS VKGHLMGEVIATVLSPEGLSILTNLPKGSAEAELMSVAPVFYVFHYLEASNNWHVLGPETLTSRTQMRRK MKEGIVSILSFRNSDFSYSMWKNGQASTWLTAFALRILGQVNQYVNLDQISVCNTLLWFIENCQMPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSVIGIEKSIKMCPTQKIHDAKNKAGDYLLKNAQSAQSPFTM AIISYALALVDLNHQAARSLFSALKREASVIGDPPIYRFWKDGFKTPDLHAPSSVTAQMVETTAYALLTA LLRGDKSYANPIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVKRLHLDMGVKVAYKNHGDLHVFKL TEDNFVGRAVTVPLDDDIYVSTGSSTGIATINVRTVYNVMGTSEESCNFELKIAPKRDNGYRGEDGEPLG HLEACAKYRPSTREPQSGSAHAVMDISLVSGLVANTEDLSTLASGVDQLIADYEIKDGHVILQIDSVPAD RFLCVGFRISQLFHVGMLNPGTFTVYEYHAPDKRCAVFYNPYGNEKLVRLCEGDECKCMEAECSKVQERL DRSITAGTRREVACQNDIAYVYKVNILSRSEEGYFVKYSATILDLYKRGQAFAQKNNEITFVKKKTCTDV ELSPGMQYLIMGKEALKINIGYSFRFQYPLDSSTWIEWWPSNPACTFCQEFLNRMEDFVEDLIISGC >XP_024785786.2 complement C5 isoform X1 [Pan paniscus] MPGSLGREASGRAGSTGCGAFAFGLRCRYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKF SYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKKMPITYDNGFLFIHTDKPV YTPDQSVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAK YKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIRED LKDDQKEMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPG IKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVD DGVASFVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNI IVTPKSPYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAEL VSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVF QFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRMLQKKIGEIAAKYKHSV VKKCCYDGACVNNDETCEQRAARISLGLRCVKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE IRSYFPESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVAISNNGICVADTVKAKVFKDVFLEMNIPYSVV RGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSTHLVTFTVLPLG IGLHNINFSLETSFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIK RILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQK LKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLD NGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQS TFTLAISAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYA LLTSLNLKDINYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDIDVSYKHKGALH NYKMTDKNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGY GNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQL NSIPSSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGATCKCVEADCGQ MQEELDLTISTETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKV TCSNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLN GC >XP_023098426.1 complement C5 [Felis catus] MGLWGILVFLIFLGKSWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISLKSYPDKKFSYSSGY VTLSMENKFQNSAVLTVQPKQLSGGQNPVSHVYLEVVSKHFSRSKKVPITYDNGFLFIHTDKPVYTPQQS VKVRVYSLNDDLKPAKRETVLTYIDPEGSEVDIMEENDYTGIISFPDFKIPSNPKYGVWTIRAKYKEDFS TTATAYFEIKEYVLPHFSVSIEPENSFIGYKDFNDFEITIKARYFYNKVVTEAEVYITFGIRDDLKDDQK EMMQKALQNTMLINGIAQVTFNSEMATKELSYESLEDLNDKYLYIGVTVIESTGGFSEEAEIPGIKYVLS PYKLNLVATPLFMKPGIPYSIKVQVKNSFDQLVGGVPVTLSAQTVDVNQEMSNLESKKSVTHSSDGVASF MVNLPSGARMLEFNVKTDDPDLPEENQAGKVYQAIAYSSLSQSYLYIDWTGNYKPLLVGEYLNVIVTPRS PYINKITHYNYLILSKGKIVHFGTREKLPDSSYQNINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLQVHLSPSADASYSPSQHVSLNMATESNSWVALSAVDSAIYGVQRRAKKPLERVFQVLET SDLGCGAGGGRNNADVFHLAGLLFLTNANVDDTREDDKPCKEILRPKRMLQKKIQEEVAKYKHTVLKKCC YDGAYRNEDEDCEQRAARITIGPRCVRIFKECCLIAKKHRDEDPLKNIQLGRLHIKTLLPVSKPEIRSYF PESWLWEVHHVPRRSQLQFVLPDSLTTWEIQGVGISNSGICVADTLKAQVFKDVFLEMNIPYSVVRGEQI QLKGTVYNYRMSGMRFCVKMSTVEGICTSGSQAIGHQGINPSKCLSQRVEGSSSHLVTFSVLPLEIGLHN INFSLETSLGKEILVKTLRVVPEGIKKESYAGVTLDPRGIYGVVSRRKEFPYRIPLDLVPKTKVKRIVSV KGLLIGEVMSTVLSQEGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGKNWNIFSTNSLIQNQNLRKKL KEGMVSIMSYRNADSSYSMWKGGSASTWLTAFALRVLGQLNKYIEQNQNSICNTLLWLVENCQLENGSFK ENSDYQPIKLQGTLPVEARENTLYLTAFAVIGIRKAFDICSLMKINTAITKADTFLLENTLSAQSTFTLA IAAYALSLGDKTHPQFRSIVSALKKKALVKGDPVIYRFWKDDLQQESTSTPSPSTAHVVETTAYALLTSL SLKDINYVNPIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIKQLHLNMDINVSYKHKGDLHRYKMT ETNFLGRPIEVPLNDDLVVSTGYSNGVATVHVTTVVQKTSTSDEICSFHLKIEAQDIEASSYRRYSDSDY KRIVACASYKPSKEESSSGSSHAVMDISLPTGIGANQEDLKALVERVDQLLADYQIKDGHIILQLNSIPS DEFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMFYNPFDARLQKVCEGVTCKCIEADCGQMQTEL DLTISADTRKETACKPDIAYAYKVRITSITKENVFVKYTATLLDIYKAGEAVAQKDSDVTFIKKVTCANA DLEKGRQYLIMGKEALQIKYNFSFKYLYPLDSSTWIEYWPTNAMCPSCQAFLANLDEFAEDIFLNGCENP >XP_030870703.1 complement C5 isoform X1 [Gorilla gorilla gorilla] MGLLGILCFLIFLGKTWGQEQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSYPDKKFSYSSGH VHLSSENKFQNSAILTIQPKQLPGGQNPVSYVYLEVVSKHFSKSKKMPITYDNGFLFIHTDKPVYTPDQS VKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDHIGIISFPDFKIPSNPRYGMWTIKAKYKEDFS TTGTAYFEVKEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKVVTEADVYITFGIREDLKDDQK EMMQTAMQNTMLINGIAQVTFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLS PYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLAGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVASF VLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNHKALLVGEHLNIIVTPKS PYIDKITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKPLERVFQFLEKS DLGCGAGGGLNNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKAIEEIAAKYKHSVVKKCCY DGACVNNDETCEQRAARISIGPRCVKAFTECCVVASQLRANNSHKDMQLGRLHMKTLLPVSKPEIRSYFP ESWLWEVHLVPRRKQLQFALPDSLTTWEIQGVGISNSGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQ LKGTVYNYRTSGMQFCVKMSAVEGICTSESPVIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNI NFSLETSFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTISRRKEFPYRIPLDLVPKTEIKRILSVK GLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLK EGMLNIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLDNGSFKE NSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAI SAYALSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQHKDSSVPNTGTARMVETTAYALLTSLN LKDINYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLNMDIDVSYKHKGALHNYKMTH KNFLGRPVEVLLNDDLIVSTGFGSGLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEASHYRGYGNSDYK RIVACASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSS DFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSASNIKIQKVCEGATCKCVEADCGQMQEELD LTISTETRKQTACKPEIAYAYKVSITSITVENVFVKYKATLLDIYKTGEAVPEKDSEITFIKKVTCTNAE LVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTWIEYWPRDTTCSSCQAFLANLDEFAEDIFLNGCQNS >XP_011478017.1 complement C5 [Oryzias latipes] MKVCVLLLCVCCLCWRTQAQPKSYLVTAPSSFRVDAVETVFVQLFGYTREVTVFVFLKDSMAPNHKLLSR DVLTLNANNKFQALANVQLYPNVLTKDIQKVVLHVQSDEINNHVFVPISRSNGFMFIQTDKPLYTPHQNV KVRAFSMNQELRPANRSVFLTFKDPDRVTVDVVEMVDINNGIPTMQKRFKIPIKPKLGIWTIEASYSDDF TTTAVTDFEVKEYVLPSIDINVQPSLNFISDTNFNSFDFKISARYVHGAPVADGEVFLRYGYVSGKNAPF IIPNLVKRERLSSSGEVEVNLNMQEVLSKHDGPRELSSLVGKYLYMAVLVQEETGGISQEAEFASVKFLK SPYHLSLISTPPFIKPGLPYNIKLLVKDHLDKPVNRVSVELVEQRQITETGETNVLNCGNNNQLRSDSDG FIYLICNPWKTSVKAVLKFQTAGLAEANRATLTLESVAYHSPNERYLYINTPMFGKSLVVGRDTQIQVQT ASPSYLNIQALNYLVLSKGKVVFHKSVDFVRSLDGTNSLNFMVTPSMVPSIRLLVFYILHGEGTSELVAD SVWIDVKHKCINGLETSVTVDTRIHKPKENLNIDIRANQPGLVALSAVDSAVYSIRRNYKDPISMVLRHI EQSDLGCGGGGGKDNADVFRLAGLTFLTNANAQSTSVDEPCTAAVRSKRALSDEAKEAKAQSYGSLKPCC VKGMQYIPRSVTCRQYALQYKKLTHRCREAFRECCEFYQKNKDDGDLILARHIGVNFDEVPQVRSYFPES WLWEVQPISSGKLSVSGKLPDSLTTWEIQAVGMFPSGGMCVADTAKVSVNLPLSVDIPLPYQVVRGEQVV LQGSVYNQQDKSIKYCVTLMAGPAVCLLQSQPVSGQPGLHSTGCKWNYLSANGVGKVVFTLLGLEPGMHT LTFTLKTTDGIRDILEKNLRVVPEGVRRDVDSGGSLDPQGVYGSKKLKVVLHNQMPANVVPNSAVQRMLA INGELPGEVVTVLTKPEGIKTLIDLPLGLAIAKLDTLFLLTQVYLYLETTSSWDLFGANSQKSSADLKQK IQDGLIDLSSIRNGDSSYSTSIKAEPSTWVTAMVVKVLALADSVMSLDHQSLSESVTWLISKTQQADGSF SELSSFKPNRAMVEGADPIEKSVYVTSIVLIALQRASEIRDERLQLRFHVSSRRSAAGYLSQHARDVKSV YVRAVATYALTLHDPNSIAVSELISSLESVARQKGNPVELRYWQEADVTADWIKPDQSSGQTVETTSYVL LTMLLKGRIPYANPILSWLTQDQYYGDGFFSSTDMVLTLEALTEYKKLIPRTELDQQINIRYNRKGEVKR VALNRRQPVVAPIEISLTDDITVSTGYGKGVSNVKLKTVFYQTTASLQTRCNFELNIEMSGSNPSESSST EAPHLAACVKYKPPLNEVSTASSLTVLKIQLPTGVEPYLEDLRQFMDPDNPIISHYELQGSTVVILMDTV PSDIFLCVGFRVRTRFKVVGASDCLFTVSERQDRGSLCTKEFSPQHQMLQRLCLGEQCQCMTAACAAYRG NVDLSLTSVQRREELCQPHVKYGLIVAVRSSASEGDFMIYSASVVEVLKNTEKDLEALNPKSEVELVKKA TCTSINLQDNKQYLVFGSRGSEVQNGRHFKYRLALDSEALVELLSTDCSSDLCQKHQAQMEDFSVYFMLN ECI >XP_005512961.1 complement C5 isoform X1 [Columba livia] MTILMCFFVFLFSGTTFGQEKTYVLTAPKIFRAGASEKVVVQAFGFEKEFPVNIAIKSLPDKITVYSSDR ISLTPANKFQDAATLTLQPADLPRTENSVNYVYLEAVSPHFTRLKKIPVSYENGFLFIHTDKPIYTPDQS VKVRVYSLNEELQPARRETVLTFVDPEGVKVDIVEEEDFTGIVSFPDFKIPPNPKYGIWKIEAKYKKNFI TSAVAKFEVKEYAMPSFSITIEPESNFISSDKFESFRIVVKASYFYNKRLPSADVFLRFGIIEESEKRMM PRAMHVTRIENGVAAINFNSKQAVSFIGFQSLEELDGSYLYIVASVLESEGGLSGEAEFAGVRFAVSPYK LSLIATPLFVKPGLPFFIKVQVKDTGDHFVGNVPITISAKSVGEQTDETELISEHSESRRRKTSTNDGTA LFVVNIPSDCKILEFQVKTADPHLSDENQASKTYEAKAYSSLSQSYLYIDWASNHKILEVGDFVNIKVYP HSRYIHKIHHYSYLITSKGKIVSFGTQKRMKDLEYEHLTFQITQEMVPSARLIVYYIVMGEEAAELVADS IWLNVEQKCGNSLDIRLQSSKEILKPAEAISLDMKTEFSSFVALSSIDKAVYGVTASGKRAMEKIMLHLE KSDLGCGAGGGRNNIDVFRMAGLTFLTNANADDSNEAGETCNEVLRTKRSDFKEKILKEASKYTHPEVRK CCMAGVKAYPVSETCSDRARRIRRNEKCISAFTDCCEFANRLREEEPNKLLILARMHFESVLELDEAEVR SYFPESWLWEVHQVSPRSKTLSVTLPDSLTTWEVQGVGISDKGICVAAPLEVPVVKDIFLSVYVPYSVVR GEQIELKGSVYNHRDSPIKFCVKIAAGNGICAFDSATAGSRMHSCNLKNLDGGSSAPVTFRILPLELGLH TINFTLLTARNSEIVVKTLRVMPEGVKKELHAGFTLDPQGVYGSIKRRQEFRYKIPLNLVPKTKIDRSVS VKGHLMGEAIATVLSPSGLGVLTALPKGSAEAELVSIAPVFYVFHYLEESNNWHLLGPETLTSRTRLRRK MKEGIVSILSFRNSDFSYSMWKNGQASTWLTAFALRILGQVNQYINLDQISVCNSLLWLIENCQMPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSLIGIEKSIQICPTQKIHDAKNKAGDYLMKNVRSAQSPFTM AITSYALALMDLNHLSARAAFSALKKEASVIGDPPIYRFWKNTFKTPDQHTPSPVTAQMVETTAYALLTT LLRGDANYAKPIIKWLSEEQRYGGGFYSTQDTINALEALTEYSLLVKRLSLDMSVKVAYKNHGNLHLFKL TEDNFVGRTLTVPLGDDIYVSTGSSTGIATVNVKTVYNTIGTSEESCNFELKIVPKRADGYRKEDGEPLG RLEACAKYRPGVREPQSGSAHAVMDIGLVSGLEANTEDLSTLASGVDQLIADYEIKDGHVILQIDSVPAN NFLCVEFRISELFQVGMLNPATFTVYEYHAPDKRCTMFYNPYGNEKLVRLCEGDECKCMEAECSKVQERL DRSLTADTRREAACQSDIAYVYKVNILSRSEEGYFVKYSATLLDLYKRGQAFAQKNNEVTFVKKKTCTDV ELSPGEQYLIMGKEALKISVGYNFKFQYPLDSSTWIEWWPSNTACAYCQEFLNTMEDFTEDLMISGC >XP_013821764.2 PREDICTED: complement C5 [Capra hircus] MGLRGILCFLIFLGKSWGQEQTYVISAPKVFHVGASENVVIQVYGYTEEFDATVSIRSFPDKKVTYSSVH VTLSAENKFQNSATLTIQPKQLSERQSSVSHVYLEVISKHFSQAKKMPITYDNGFLFIHTDKPVYTPHQS VKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMIEENDYTGIISFPDFKIPSNPKYGVWTIRAKYKEDFS TTGTAYFEVKEYVLPHFSISIEPESNFIGYKDFTNFEITIRARYFYNKVVNEADVYISFGIRDNLEDNQK EMMQKAMQSRTLINGIAQVTFNSETAVKELSYESLEDLNDKYLYIGVTITESTGGFSEEAEIPGIKYVLS PYKLNLVATPLFVKPGIPYSIKVQVKDSFDHLVGGIPVTLSAKTFDVNQEISDLESKKSVTRSSDGVASF VVNLPSEVTVLEFNIKTEDLDLPEENQASEDYRAVAYSSLSQSYLYIDWTENYKHLLVGEHLSIVVTPRS PYIDKITHYNYLILSKGKIVHYGTRDKLSDSAYQSINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLEVHLSPRTDTYSPGQRVSLTMETELDSWVALTAVDSAIYGVQRTAKRPLQRVFQTLETS DLGCGAGGGRDNADVFYLAGLTFLTNANADHTREDDEPCKEILRPKRMLKKKIEEEAAKYRHINVKRCCY DGAHRNDDENCEQRAARIKKGPICIKAFKECCAIASEFRANKTYKNIQLGRLHVKSLLPVTKPEIRSYFP ESWLWEVHHVPKRNQLQFVLPDSLTTWEVQGVGISNSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQ LSGTVYNYRTSGIQFCVKMHPVEGICSSGSPGTDSQGRRFSKCVPQKIEGSSNHLVTFTVLPLEIGLHNL SFSLETSVGNEILVKTLRVVPEGVKRESYAGVTLDPQGIYGIISRRKEFPYRIPLNMVPKTKVKRTVSIK GLLIGEVMSAVLSEEGIDSLTHLPKGNAEAELMSAVPVFYVYHYLEAGHNWDIFSTNSLTQKQNLKTKLK EGMASIMSFRNADYSYSMWKGGGASTWLTAFALRVLGQISKYVDQNQNSICNSLLWLLEKCQLENGSFKE NSDYQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDICPLEKISTAVSKADIFLHENALSTQSAFTLAI AAYALSLGDKSHPQFRSIVSALKKKAFVKGNPPIYRFWKDDLEQKDSSAPNTGTARMVETTAYALLTSLS LKDMNYVSPIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLGRKLRLNMDVKVSYKNKGDLYHYKMSE KYFLGRPIEVPLSDDLVVLSTGQSSGLATVHVKTVVHKISTSEEVCSFHLKIETREIEAFGYSSSEYKRI VACASYKFSSEESSSGSSHAVMDISLPTGVNANPEDLKALVEQVDQLLTDYEIKDGHVILQLNSIPSNEF LCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSHTKLQKVCEGATCKCIEADCGQMQAELDLT ISAATRKERACKPDIAYAYKVEIIAVTEENAFVKYTATLLDVYKAGEAAAERDAEITFIKKTTCSNANLE KRKQYLIMGKEALQIKYNFRIKYVYPLDSSTWIEHWPTDSRCPSCQRFLANLDAFTEDIFLNGCENA >XP_014382164.1 complement C5 [Alligator sinensis] MRFHQYLLASLGWCLSAMNIFSFFCILVVCGRSVSQEQTYVVSAPKILRVGASEKVVIQAFGYKNEFSVN IAIKSYPDKQTVYSSGRVSLSSANKFQGSVTLMIQPKDLPGPGSSVHVYLEASSVHFTREKKMLVTYDNG YLFIQTDKPIYTPDQSVKVRVYSLNQELKPAQRETVLTFVDPEGVKVDIIEENDFTGIVSFPDFKIPSNP KYGTWKIEAKYKKSFTTTAFTKFEVKEYAMPSFSVSIEPEYNFISFEKFEKFKITIQASYFYNKVVAWAD VFVRFGIIEANEKTMMPKAMHVAEMTNGVAEINFNSRNAVRDIGRQSLEELNGAYLYIAATVLESDGGHS EEAEFFGVKFVLSPYKLNLVATPLFVKPGLPFSIKVQVKDTLSQPVGNLPVTLTANVVNEQMDSTHLVRE GSESGRRQTSRTDGTALFIVNIPSDSKTLEFQVKTADPSLSEENQATERYEATAYSSLSKSYLYIDWASN HKMLHVGDHININVHPSSHYIHKIYYYSYLILSKGKIISFGTQARINDTDYEHVSFQLTQDMVPSARLLV YYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSSRQESYKPGKNIPFYMKTQFSSFVTLSSMDKAIYGV AGTRKRSMERVMLELEKSDLGCGAGGGQNNVNVFRLAGLTFLTNANADDSKDADEMCAAIVRSKRFDFEE EIKKRASRYVLEAVRQCCMDGVRAYPVSETCEERTKRVQGGPKCLYAFKDCCEYANQLRQQEPNKVLMLA RKQFEAFLDLVKPEVRSYFPESWLWEVHQVPQGSKSLPVTLPDSLTTWEIQGVSISDKGICVADPLEVQV FKDVFLSMHIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVAAGEGICLFGESSTGPQRMRNCKFSNIESS SVSSVTIRLLPLELGLHTINFTLYTGRDSEILVKTLRVVPEGIKRELNAGFTLDPKGVYGSVRTRQEFRH RVPFNMVPKTKMDRTVSVKGQLMGEVISAVLKPEGVGFLTNLPKGSAEAELMSIVPVFYVYHYLEKTSNW DLLGTEILTSEVKMKRKMKEGIVSILSFRNRDFSYSMWKDGKPSTWLTAFALRIFGQVSEYIDLDHISVC NSLVWLTDCCQMSDGSFKELSSYQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHMCPVQKLQDAKLKA EEYLLRNVQASQSTFTLAITCYALALMDLNHPGTRLAFGNLKKEAFAKGEPPIYRFWKDTLKSLDAFTPN AGTAQMVETTAYALLTTLKGGDKMYANPIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILAARLSLDM NVKVAYKNHGDLHLYKLTEQNFIGRPVTVPLDEDIYVSTTGNTGLATVNVRTVYHTISTSDEICNFELTV TPKTKQDERRQEGEKPERLEACAKYKPGVREPQSESAHAVMDISLPSGVEADEEDLYILATGVDQLIRSY EIKDGHIIIQIDSVPANKFLCVAFRINEIFHVGMLSPATFTVYEYHAPDKKCTIFYNPYGDDRLVRLCEG NECKCMEAECSQMRKKLDLSVSADTRNEVACQQDIAYVYKVKILSYKEEGSFIKYTATLLDVYKRGGALV KKNDETTFVKKNTCSDVVLNPGEQYLIMGKEALRIVVGFSFKYQYPLDSKTWIEWWPSNTACPSCKQFVA TMEGFVEDLLISGC >XP_014459225.1 PREDICTED: complement C5 isoform X1 [Alligator mississippiensis] MWFHQYLLASLGWCLSAMNIFSFFCILVVCGRSFSQEKTYVVSAPKILHVGASEKVVIQAFGYKNEFSVN IAIKSYPDKQTVYSSGRVSLSSANKFQGSVTLMIQPKDLPGPGSSVHVYLEASSVHFAREKKMPVTYDNG YLFIQTDKPIYTPDQSVKVRVYSLNQELKPAQRETVLTFVDPEGVKVDIIEENDFTGIVSFPDFKIPSNP KYGTWKIEAKYKKSFTTTAFTKFEVKEYAMPSFSVSIEPEYNFISFEKFEKFKITIQASYFYNKVVAWAD VFVRFGIIEANEKTMMPKAMHVAEMTNGVAEINFNSRNAVRDIGRQSLEELNGAYLYIAATVLESDGGHS EEAEFFGVKFVLSPYKLNLVATPLFVKPGLPFSIKVQVKDTLSQPVGNLPVTLTANVVNEQMDSTHLVQE GSESGRRQTSRTDGTALFIVNIPSDSKTLEFQVKTADPSLSEENQATERYEATAYSSLSKSYLYIDWASN HKMLHVGDHININVHPSSHYIHKIYYYSYLILSKGKIISFGTQARINDTDYEHVSFQLTQDMVPSARLLV YYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSSRQESYKPGKNIPFYMKTQFSSFVTLSSMDKAIYGV AGTRKRSMERVMLELEKSDLGCGAGGGQNNVNVFRLAGLTFLTNANADDSKEADEICAAIVRSKRFDFKE EIKKRASRYVLEAVRQCCMDGVRAYPVSETCAERTKRVQGGPKCLYAFQDCCEYANQLRQQEPNKVLMLA RKQFEAFLDLVKPEVRSYFPESWLWEVHQVPQGSKSLPVTLPDSLTTWEIQGVSISDKGICVADPLEVQV FKDVFLSMHIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVAAGEGICLFGESSTGLQRMRNCKFSNIESS SVSSVTIRLLPLELGLHTINFTLYTGRDSEILVKTLRVVPEGIKKELNAGFTLDPKGVYGSVRTRQEFRH RVPFNMVPKTKMDRTVSVKGQLMGEVISAVLKPEGVGFLTNLPKGSAEAELMSIVPVFYVYRYLEETSNW DLLGTEILTSEVKMKRKMKEGIVSILSFRNPDFSYSMWKDGKPSTWLTAFALRIFGQVSEYIDLDHISVC NSLVWLTDRCQMSDGSFKELSSYQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHMCPVQKLQDAKLKA EEYLLKNVQAAQSTFTLAITCYALALMDLNHPGTRLAFGNLKKEAFAKGEQPIYRFWKDTLKSVDAFTPN AGTAQMVETTAYALLTTLKGGDKMYANPIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILAARLSLDM NVKVAYKNHGDLHLYKLTEQNFIGRPVTVPLDEDIYVSTTGNTGLATVNVRTVYHTISTSDEICNFELTV TPKTEQDERRQEGEKPERLEACAKYKPGAREPQSESAHAVMDISLPSGVEADEEDLYILATGVDQLIRSY EIKDGHIIIQIDSVPANKFLCVAFRINEIFHVGMLSPATFTVYEYHAPDKKCTIFYNPYGDDRLVKLCEG NECKCMEAECSQMRKKLDLSVSADTRNEVACQQDIAYVYKVKILSYKEEGSFIKYTATLLDVYKRGGTLV KKNDEITFVKKNTCSDVVLNPGEQYLIMGKEALRIVVGFSFKYQYPLDSKTWIEWWPSNTACPSCKQFVE TMEGFVEDLLISGC >XP_008271599.1 PREDICTED: complement C5 isoform X1 [Oryctolagus cuniculus] MGLWGIFCFLIFMGKSWGQEQTYVISAPKVLRVGASENIVIQVYGYTEAFDSTISIKSYPDKKFSYSSGY VSLSSENKFQNSATLTIQPKQLSTGQNAPSHVYLEVVSKHFSRSKKMPITYDNGFLFIHTDKPVYTPHQS VKVRVYSLNDDLKPAKRETVLVFIDPEGSEVDMVEENDYTGIISFPDFKIPSNPKYGVWTIKAKYKEDFS TTGTTYFEVKEYVLPHFSVSIEPESNFIGYKNFKNFEITIKARYFYNKVVSDAEVFIFFGIREDLKDDQK EMMHKAMKSTTLINGVAQVTFDSEVATKELSYYSLEDLNNKYLYIAVTVIESTGGFSEEAEVPGIKYVLS PYKLNLVATPLFLKPGIPYSIKVQVKDSLDQFVGGVPVMLNAQTVDVNQQTSDLETKGSVTRLSDGVASF VVNLPSGVTALDFYVKTNAPDLPEDNQASRKYHAVAYSSLSQSYLYIDWTENYKALLVGEHLNLIVTPKS PYIDKITHYNYLVLSKGKIVHFGTREKLSDSSYQSMNIPVTQSMVPSARLLVYYIVSGEQTAELVSDSVW LNIEEKCGNQLQVHLSPDEDVYSPGQSVSLSMETESHSWVALTAVDSAVYGVQKTAKKPMERVFQALEKN DLGCGAGGGRNNAEVFNLAGLTFLTNANADSSQENDEPCKEVLRPRRMLQQKIQEAAAKYKHPVVKRCCL DGAHRNDDETCEQRLARVTKGPHCARAFNECCSIARQFRDKHSHKNIQLGRLHTKTLLPVSKPEIRSYFP ESWLWEVHHVSKRNQLQLVLPDSLTTWEIQGVGISNSGLCVADTLKAKVFKDVFLEMNIPYSVVRGEQIQ LKGTVYNYRTSGMMFCVKMSTVEGICTSGNLAADHQGTKSSRCVRQKVEGSSTHLVTFSVLPLETGLHSI NFSLETSFGGETLVKTLRVVPEGVKRETHAGVTLDPRGIYGVVSRRKEFPYRIPLDLVPKTNVERIVSVK GLLIGEVLSAVLSKEGINILTHLPKGSAEAELMSVAPVFYVFHYLETGNHWDIFSPNSLIKKQDLKKKLK EGIVSIMSYRNADHSYSMWKGGSASTWLTAFALRVLGQVNKYVEHNQNLICNSLLWLVENCQLENGSFKD DSKYQPIKLQGTLPVEAKENSLYLTAFTVIGIRKAFDLCPLLKISTALTKAENFLLENTLPAQSTFTLAI AAYALSLGDRTHPQFRAIASALKRAASVKGGSPPIYRFWKDGLQQHKDTSAPNAGTAGMVETTAYALLTS LNLKEMNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLQLDMDINVSYKHKGNFQNYKI TEKNFLGKPVEVPLDDDLVISTGHSNGLATVHVATVVHKTSTSEEICSFHLKIEAQDIEASYYSDLGYKR IIACASYKASGEESSSGSSHAVMDISLPTGISANQDDLRALVEGVDQLLTDYQIKDGHVILQVNSIPSTD FLCVRFRIFELFQVGFLSPATFTVYEYHRPDKQCTMFYSTSNTKLQRVCEGTLCKCVEADCGQMEKELDL TISAETRKEKACKPEIVYAYKVSITSITEENVFVKYTATLLDVYKTGEAIAEKGSEITFIKKTTCANADL LKGRQYLIMGKEALQIKHNFSFKYIYLLDSWTWIEYWPSDTTCPSCQAFSANLDEFAEDIFLNGCENA >XP_015815864.1 PREDICTED: complement C5 isoform X1 [Nothobranchius furzeri] MKVLALLVCVWCLGWRTNAESKSYVITAPLSLHLDAVETVFVQLFGYTSEVPVYVFLRTSMAVNNKVLFQ DVVRLNSLNGYQGVANVRLFPNKLGKDVNQVVLHVQTSDINQHQPIPISRTNGFLFIQTDKPLYTPNQKV KVRAFSMNQELRPANRSVFLTFKDPEQVPVDVVEMIDVNNGIPSMQNPFKIPVKPKLGIWTIEAAYSDDF NTKATTDFEVKEYVLPSFSILMNPQTNHISFSEFRRFTFRISARYLHGAPVTEGLVYLRYGYVRGTGAPV IIPKSFSQERLSQTGEVDVTVDMQTVLQKHDGPKDISSLVGSYLYIAVLVKEDTGGITQEAEFASVKFVR SPYHLSLISTPPFIKPGLPYNIKVLVKDHLDKPMSKVSVQLTEKQLVMNGGSTVDMSCQGSGDSSSDGLV YFICHPLKNSARAVLKFQTADPTLPSSSQASLTLEPVAYQSPNQRYLYIDTPMFGRSLEVGRYTNIHVYT ATPSYLNIRTLNYLVLSKGKVVYFRTLNFVNTSDNKQTLNFQVTSSMVPSIRLLVYYVLHGEGTTELVAD SVWMDVKDKCLNGLQMDVSLRSETHKPKDNVNLDIRANQDGLVALSAVDSALFTLRPYYKDPVFTVLRHI EKTDQGCGGGGGKNNADVFRLAGLTFMTNANAHPLSSTEPCTAVVRPKRALSQEEINNKARRYGRFKTCC ERGMDYIPKSVTCERYAQQRLRSKPPADCIKAFRECCEFFQQSQDQNDVLVLARTALGANFDLAPMVRSY FPESWLWEVQRTSSGQLPIRKSLPDSLTTWQIKAVGMFQNGMCVADPVEVSVNLPLSVDVPLPYQVVRGE QVELRGSVYNQKEDSITYCVTLTAGPALCLLQSHPVNDAGLHSTTCTFRHLLAGGVGVVNFTVLGLEPGE HTLTFTLKTRAGVADVVEKLLRVVPEGVRQEVNFGGILDPQGLYGSEKRTVVLKNRLPENIVPKSDVERL LTINGELPGDVATVLLNPEDLKQLISLPPGSAEAELQGLLPLIQVYQYLETTGSWDVLGGDVGKMSGDLR QKIKEGLVAISSFRNGDSSYSMWIKSEPSTIVTAEMIRALSMADAFLSVDHQSLSDSVGWLIRRTQKEDG SFAEKSSSRLIQILGGGEEEVEQSVFVTSVALIALHRATSIRDQILRLRSHEASKRSAANYISQHALSVR SVYVRALATYALTLQDSNSEEVSQLITSLEGLARQKGNPVTLRYWQESSVTTDWLKPDKSSGQTVETTAY VLLTMLLKARISYANPILAWLTQDQHYGGGFFSIKDAVLTLEALTLYKSVMTRSVLNQEINIRYKVKGPL GRVSLSQTRPVATPIQVTKNDDITVTTGYGRGVSSVKLKTVFYQTTASTQPRCNFDLTIEVVGPSVSDNP SMKAPHLVACVKYRPPPNEVATESSLAVMKIQLPTGVEPYLEDLRQFRDDEESLVSHYELQGSTVIIQMD WVPSQVFVCVGFRVRTGFKVVGATESWISVTEPQEKGSLCSKQFSSEQQKLQRLCVDHQCQCMTAACASY RGTTTNTLTLEKRIEEICKEQIKFAYKLTVTSSAAEGDFMTYTATVDQVLRPSNEFEAVSSGTEVDLVKK ATCSSVDLHDNRQYLVMGSSGSEVTHNNGFRSVPPWSVDVLVSRGADGFWSISGTGFLWTLMPWWSSGLR VALQSVRTTFPRWRN >XP_030272007.1 complement C5 [Sparus aurata] MKLCVLLMCVCCLCWRTEADSRTYLITAPLSLRLDAVETVLLQLFDFTDEVTVYVYLKTSMAANHVILAQ EVVTLNAANDYQAAARVRLFPGQLDKSVSHVILHVQSPVINGHLSIPVSRTNGFLFIQTDKPLYTPDQSV KVRAFSLSQELRPAQRSVFLTFRDPQNVIVDIVEMIDANNGIPSMQNPFKIPIKPKLGIWSIEASYSDNF TTSARTEFEVKEYVLPSFSIQMEPESNFISYGKFNSFNFKVSARYLHGAPVADGEVFLRYGYIRGKNPPV LIPSSVSRERLSSTGEVDVTVNMEKVLSKHDGPKDLNSLVGMYLYVAVLLQEDTGGLTQEAEFAAVKFVK SPYSLSLVSTPPFIKPGLPYNIQVLVKDHLDKPVHRVRVRLSERQLFKGGGESEQIPCPDSANSQSDGLA VFICNVPSDGVRAVLKFDTADPALPAASQAALSLEAVAYHSPNQRYLYIDPPLPGRGLEVGRFARIKVYS ATPSYVPVKALSFLVLSKGKVVEFGSQKFISSADHRQTLSFLVKPSMVPSIRLLVYYILYGEGTSELVAD SVWLDVRDKCVNGLQTEVSYRVRDYKPKERFQLDIRANQEGLVALSAVDSALFILRPNYRDPVSTVLRHI EQSDLGCGGGGGRDSADVFRLAGLTFITNANANPLSSTETCTAAVRPKRALTEEQKKKKAHTYGRAKTCC ENGMKFIPKIMTCQKFADQHYSKVPLPCRQAFRECCEFMQQHLDQDQGLVLGRNALGADFDQAPSLVRSY FPESWMWEVQPVSPGQRSTVRTLPDSLTTWQIRAVGMFNDGICVAEPLLVSVNLPLSVDVPLPYQVVRGE QLELKGSVYNQQPDPITYCVTLTVGPALCLLQSQPAAGGAGLHSTTCSWSRLSAKEVGKVSFTVLGLEPG EHTLTFTLKTRNGPKDILEKKLRVVPEGVKKELMSGGTLDPQGRYGSEKRTVELKNNLPINIVPNTAVQR MLTVHGEVLGDVLSVALSPEGIRQLVNLPAGSAEAALDEVLPLIQVYQYLETARHWDILGGNIQENSRDL RRKIREGLVAISSFRRGDSSYSMWMNSKSSTWLTAQVVKTLSAADQLVSVDHQSDHRQSLSESVAWLIRS SQQPDGSFTDASSFRANKVMAAGANAVDQSVYLTSFVLIALHKATSIKDPILQLQFQEDSKTSAANYISQ HASGVKSLYVRAVATYALTLHDPNSMAASTQLLHLERKAQSKGNPVVLRYWKEANVTADWLKPDQSSAQT VEMTVYVLLTLLLKGRIQDANPVLSWLTQDQHYGEGFYSIQDTVLTLEALTEYSTAVPRAVLDQDINIRN RKGSVGRVQLTQSRPVASPIQVTNNEDITATTGYGRGVSTVKMKTVYYETTASNQNCNFDITIEVAGPDT SSNPSMSAPHIVACAKYNPPPNELSTESGLTVMKIQLPTGVDAYLEDLRQFRDAMEPSVSHYELQGHTVV IQMDAVPSDRFLCVGFRIRTAFKVTGESESLFSVYEPQDKGSLCTKQFSSQEQSLQRLCVGQQCQCMTAA CAAYRGKIDATLTADKRTDETCKPHIKYAYKVTVVSSAAEGDFMTYTATVVEVLKNSDKEFEAVSSGTEV DLVKKITCSAVDIQNNKQYLVMGSSGSEVKLNQGFKYRLPLDSEALVELWPTDCSSPECLDYVSQLDDFA LDLQLASCPAS >XP_040179981.1 complement C5 isoform X1 [Rana temporaria] MMILLQIALLIAVCGRSQSQEQTYLVTGPRLWRIGAQETVVIQAFGQTENFPIKMSLLSFPDKRTTYAVQ SIDLTPANKFQGLINLQIQPKDLPRKDGEMQYIYLQAQSKSFTKEEKVAVIYENGHLFIQTDKAVYTPDQ SVKIRVYSMDEELRPARRRVTLTFLDPEKVKMDIITQDDVTGVISFPDFKIPANPRYGLWSIEAAYESDY VTSSLVKFEVKEYVLPRFFVTIEPERNFISHDTFKDFSVTVKAKYYYGRIVEKGKAFIRYGLLINGEKKL MAKSIDVLQMTNGEAVFQFNSERSVAELQYSSLEELEGALLYITATVEEEEGAQSEESENANVKYVLTPY RLTLIATPLFVKPTLPYHIKVQVKDTLENPASRIPLVLTGEFAKENGESTPVDNGEAITQKTDIKGTSMF VINIPADVTALDFRIKTDDPNLQEENQALAEFKATSYKSLTKSYLYIDWARESKVLQVGGFLNVNIFPKS PYLHKLTHYSYLIISKGKILKYDTVERLSGSVSQYLNIQITVNMVPSFRLLIYYIVTGESTAELIADSIW VEVQENCLNNQKVKLSVPSDTFKPKENVTLNVNALTGSIVALSAVDVSIFDVTKKAQRPLERVLRKIEDS DLGCGAGAGQNNVDVFQTAGLTFLTNANIQATQSLDWKCNAILRSKRSLEDEIKKEARKFQNESIKRCCM DGGFNLIKENECKKGVERVQKLKPNFQMCAKVFAKCCKLAEGLKAQLDKEKKELQLGRMYIKTILNLDEP EIRSYFPESWLWEEHAITDRSSSKKVDISLPDSLTTWEVQGVSMSDKGICVADPLTFTVFKDLFLDVQLP YSVVRGEQVQIKVIVYNYQPYKVMGCVRVSVGKEVCLVSDSSSSRNGSPRNCRDEIHPLSPKTFTYNLLP LELGLHPIIFTLHAPKREIVIKNLRVVPEGIQEENSMGFTLDPQGIRGIMKRNQDVAFKIPSSIVPKSKI SRILSINGNILGEVIDTIVSGKSIQTLVSIPKGSAETDLMRVAPIFYVYHYLQTKNEWSLLGPNTFMIQI DMQKKLKDGVSSILAFRKGDHSYSLWRDSDPSTWLTAFALRTFGEVHKYVPLDHMSVCNSLIWLIEKCQS KDGSFQEKSSSLPIKLQGTIPREAAEKTLYLTAYVVIGIQKSLNMCPLAQIDNALRLAVDYLSKQASSAQ SMYTMAVCAYALQITDTTLQSKLQVMTKIKGEALTKGSSFPPVYRYWKDTLKKFDSVTPSTETAVMVETT AYTLLAVLKSGDYEYAKPVVRWLKEQQRYGGGFFGTQDTVIALEALTEVAILEKKLNLNMDVTISYRRAG LFKNYQLTERNPFTKPVEVPILEDLLISTRSAYGIATGNVKTVYNIISPPQENCRFDLKIQKKLPSEDQS IFSDDTSQALLLEACAKYKPNKNENPESGQAVMEITLVTGLLADEKSLNELVNRVDQFVVDYSLEDGKVV LHFDWIGSDEYVCATLLVRKMFKVSLISPGIFKVYEFRAPDQACTAFYNPYADDNLVRVCTGETCKCIEG ECPKLKTKLDMTTTEDQRKNVACKGDITYVYKVQIVQLEEDGDFVKYTAKILDIFKEVTALVKANKQIRF IKKKTCSSFDLENGQQYLIMGKDGIQIREEREYKYEYPLDSNSWIEWWPDASCTSRQCKPFVDLLEGVTE SILLEGCQ >XP_020749261.1 complement C5-like [Odocoileus virginianus texanus] MGLWGILCFLIFLGKSWGQEQTYVISAPKVFRVGASENVVIQVYGYTEEFDATISIKSFPDKKVTYSSGHVTLSTENKFQ NSATLTIAPKQLSERQSSVSHVYLEVISKHFSKAKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETV LTFIDPEGSEVYMVEENDYTGIISFPDFKIPSNPKYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFIGY KDFTSFEITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEMMQKAMQSTTLINGMAQVTFNSETAVKELSYESLEDLND KYLYIGVTIIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSAKTLDVNQE TSDLESKKSVTRSSDGVASFVVNLPSEATVLEFNVKTNDPDLPDENQASKDYRAIAYSSLSQSYLYIDWTENYKHLLVGE HLNIVVTPRSPYIDKITHYNYLVLSKGKIVHFGTRDKLSDSAYQSINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLEVHLSPSTDTYSPGQRVSLNMETELDSWVALTAVDSAIYGVQRTAKRPLERVFQTLEKSDLGCGAGGGR DNADVFYLAGLTFLTNANADNTQENDEPCKEILRPKRMLQKKIEEEAAKYQHIRVKKCCYDGAHRNDYETCEQRAARIKI GPRCVKAFKECCAIATQFRAEESHKNMQLGRLHIKSLLPVTKPEIRSYFPESWLWEVHHVPKRNKLQFVLPDSLTTWEIQ GVGISNSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPGIDPQGRRF PKCVPQRIEGSSTHLVTFTVLPLDTGLHNISFSLETSVGNEILVKTLRVVPEGVRRESYAGVTLDPQGIYGTITRRKEFP YRIPLDMVPKTKVKRTVSIKGLLIGEIMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVYHYLEAGNNWNIFSTNSLT QKQNLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYVDQNQNSICNSLLWLLEKCQLENGSFKE NSDYQPVKLQGTLPVEAQEKTLYLTAFAVIGIRKSFDICPLEKISTAVSKADNFLHENALSTQSAFTLAIAAYALSLGDK AHPQFRSIVSALKKKAFVKGNPPIYRFWKDDLQQKDSSAPSTGTARMVETTAYALLTSLNLKDMNYVNPVIKWLSEEQRY GGGFYSTQDTINAIEGLTEYSLLVRKLHLNMDIKVSYKNKGDLYHYKISEKYFLGRPIEVPLNDDLVVLTTGQNSGLATV HVKTVTHKISTSEEVCSFHLKIETQEIEASSYSSSEYKRIVACASYKLGSEESSSGSSHAVMDISLPTGVSANPEDLKAL VERVDQLLTDYEIKDGHVILQLNSIPSDEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSYTKLQKVCEG VTCKCIEADCGQMQAELDLTISAATRKETACKPEIAYAYKVEITAVTEENAFVKYTATLLDIFKAGEAAAERDSEITFIK KTTCSNANLEKRKQYLIMGKEALQIKYNFRFKYIYPLDSSTWIEYWPTDSRCPSCKRFLESLGEFAEDIFLNGCEST >XP_043309645.1 complement C5 [Cervus canadensis] MGLWGILCFLIFLGKSWGQDQTYVISAPKLFRVGASENVVIQVYGYTEEFDATISIKSFPDKKVTYSSGHVTLSTENKFQ NSATLTIPPKQLSERQRVSHVYLEVISKHFSKAKKMPITYHNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVL TFIDPEGSEVDMVEENDYTGIISFPDFKIPSNPRYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFIGYK DFTSFEITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEMMQKAMQSTTLINGMAQVTFNSETAVKELSYESLEDLNDK YLYIGVTIIESTGGFSEEAEIPGIQYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSAKTLDVNQET SDLESKKSVTRSSDGVASFVVNLPSEVTVLEFNVKTNDPDLPEENQASKDYRAIAYSSLSQSYLYIDWTENYKHLLVGEH LNIVVTPRSPYIDKITHYNYLVLSKGKIVHFGTRDKLSDSAYQSINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWL NVEEKCGNQLQVHLSPSTDTYSPGQRVSLNMETELDSWVSLTAVDSAIYGVQRTAKRPLERVFQTLEKSDLGCGAGGGRN NAEVFYLAGLTFLTNANADNTQENDEPCEEILRPKRMLQKKIEEEAAKYKHIMVKKCCYDGAHRNDDENCEQRAARITIG PRCVKAFKDCCAIASQFRAEESHKNIPLGRLHIKSLLPVTKPEIRSYFPESWLWEVHHVPKRNQLQFVLPDSLTTWEIQG VGISNSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPGIDSQGRRFS RCVPQRIEGSSSHLVTFTVLPLEIGLHNISFSLETSVGNEILVKTLRVVPEGVKRESYAGVTLDPQGIYGTISRRKDFPY RIPLNMVPKTKVKRTVSIKGLLIGEIMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVYHYLEAGNNWNIFSTNSLTQ KQKLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYVDQNQNSICNSLLWLLEQCQLENGSFKEN SDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDICPMEKISTAVSKADNFLHENALSTQSAFTLAIAAYALSLGDKA HPQFRSIVSALKKKAFVKGNPPIYRFWKDDLQQKDSSAPSAGTARMVETTAYALLTSLNLKDMNYVNPVIKWLSEEQRYG GGFYSTQDTINAIEGLTEYSLLVRKLHLNMDIKVSYKNKGDLYHYKISEKYFLGKPIEAPLNDDLVVLTTGQNSGLATVH VKTVIHKISTSEEVCSFHLKIETQEIEASSYSSSEYKRIVACASYKRGSEESSSGSSHAVMDISLPTGVSANPEDLKALV ERVDQLLTDYEIKDGHVILQLNSIPSDEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSYTKLQKVCEGV ACKCIEADCGQMQAELDLTISAATRKETACKPEIAYAYKVEIIAVTEENAFVKYTATLLDIYKAGEAAAERDSEITFIKK TTCSNANLEKRKQYLIMGKEALQIKHNFRLKYIYPLDSSTWIEYWPTDSRCPSCQRFLKNLDEFAEDIFLNGCESA >XP_004004015.2 complement C5 [Ovis aries] MGLWGTLCFLIFLGRSWGQEQTYVISAPKVFHVGASENVVIQVYGYTEDFDATVSIRSFPDKKVTYSSVHVTLSAENKFQ NSATLTIQPKQLSERQSSVSHVYLEVISKHFSQAKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETV LTFIDPEGSEVDMIEENDYTGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTGTAYFEVKEYVLPHFSISIEPESNFIGY KDFTNFEITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEMMQKAMQSTTLINGMAQVTFNSETAVKELSYESLEDLND KYLYIGVTITESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSIKVQVKDSFDHLVGGIPVTLSARTFDVNQE ISDLESKKSVTRSSDGVASFVVNLPSEVTVLEFNIKTEDLDLPEENQASKDYRAVAYSSLSQSYLYIDWTENDKHLLVGE HLSIVVTPRSPYIDKITHYNYLILSKGKIVHYGTRDKLSDSAYQSINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVW LNIEEKCGNQLEVHLSPRTDTYSPGQRVSLTMETELDSWVALTAVDSAIYGVQRTAKRPLERVFQTLETSDLGCGAGGGR DNADVFYLAGLTFLTNANADHTREDDEPCKEILRPKRMLKKKIEEEAAKYKHINVKRCCYDGAHRNDDENCEQRAARIKK GPICIKAFKECCAIASEFRANKTYKNIQLGRLHVKSLLPVTKPEIRSYFPESWLWEVHHVPKRSQLQFVLPDSLTTWEVQ GVGISNSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPGTDSQGRRF SKCVPQKIEGSSSHLVTFTVLPLEIGLHNLSFSLETSVGNEILVKTLRVVPEGVKRESYAGVTLDPQGIYGIISRRKEFP YRIPLNMVPKTKVKRTVSIKGLLIGEVMSAVLSEEGIDSLTHLPKGNAEAELMSAVPVFYVYHYLEAGHNWDIFSTNSLT QKQNLKTKLKEGMASIMSFRNADYSYSMWKGGGASTWLTAFALRVLGQISKYVDQNQNSICNSLLWLLEKCQLENGSFKE NSDYQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDICPLEKISTAVSKADIFLHENALSTQSAFTLAIAAYALSLGDK SHPQFRSIVSALKKKAFVKGNPPIYRFWKDDLEQKDSSAPNTGTARMVETTAYALLTSLSLKDMNYVSPIIRWLSEEQRY GGGFYSTQDTINAIEGLTEYSLLGRKLRLNMDVKVSYKNKGDLYHYKMSDKYFLGRPIEVPLSDDLVVLSTGQSSGLATV RVKTVVHKISTSEEVCSFHLKIETQEIEAFGYSSSEYKRIVACASYKFSSEESSSGSSHAVMDISLPTGVNANPEDLKAL VEQVDQLLTDYEIKDGHVILQLNSIPSNEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTSHTKLQKVCEG ATCKCIEADCGQMQAELDLTISAATRKERACKPDIAYAYKVEIIAVTEENAFVKYTATLLDIYKAGEAAAERDAEITFIK KTTCSNANLEKRKQYLIMGKEALQIKYNFRIKYVYPLDSSTWIEYWPTGSTCPSCQRFLANLDEFTEDIFLNGCANV >KAF4019645.1 hypothetical protein G4228_011172 [Cervus hanglu yarkandensis] MGLWGILCFLIFLGKSWGQDQTYVISAPKLFRVGASENVVIQVYGYTEEFDATISIKSFPDKKVTYSSGHVTLSTENKFQ NSATLTDPEGSEVDMVEENDYTGIISFPDFKIPSNPRYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFI GYKDFTSFEITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEMMQKAMQSTTLINGMAQVTFNSETAVKELSYESLEDL NDKYLYIGVTIIESTGGFSEEAEIPGIQYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSAKTLDVN QETSDLESKKSVTRSSDGVASFVVNLPSEVTVLEFNVKTNDPDLPEENQASKDYRAIAYSSLSQSYLYIDWTENYKHLLV GEHLNIVVTPRSPYIDKITHYNYLVLSKGKIVHFGTRDKLSDSAYQSINIPVTQNMVPSARLLVYYIVTGEQTAELVSDS VWLNVEEKCGNQLQVFQTLEKSDLGCGAGGGRDNAEVFYLAGLTFLTNANADNTQENAAKYKHIMVKKCCYDGAHRNDDE NCEQRAARITIGPRCVKAFKDCCAIASQFRAEESHKNIPLGRLRICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGT VYNYRTSGIQFCVKMHPVEGICSSGSPGIDSQGRRFSRCVPQRIEGSSSHLVTFTVLPLEIGLHNISFSLETSVGNEILV KILRVVPEGVKRESYAGVTLDPQGIYGTISRRKDFPYRIPLNVVPKTKVKRTVSIKGLLIGEIMSAVLSQEGIDILTHLP KGNAEAELMSVVPVFYVYHYLEAGNNWNIFSTNSLTQKQKLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALR VLGQISKYVDQNQNSICNSLLWLLEQCQLENGSFKENSDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDICPMEKI STAVSKADNFLHENALSTQSAFTLAIAAYALSLGDKAHPQFRSIVSALKKKAFVKGNPPIYRFWKDDLQQKDSSAPSAGT ARMVETTAYALLTSLNLKDMNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVRKLRLNMDIKVSYKNKGDLY HYKISEKYFLGKPIEAPLNDDLVVLTTGQNSGLATVHVKTVIHKISTSEEVCSFHLKIETQEIEASSYSGSEHKRIVACA SYKRGSEESSSGSSHAVMDISLPTGVSANPEDLKALVERVDQLLTDYEIKDGHVILQLNSIPSDEFLCVRFRIIELFEVG FLSPATFTVYEYHRPDKQCTMFYSTSYTKLQKVCEGVACKCIEADCGQMQAELDLTISAATRKETACKPEIAYAYKVEII AVTEENAFVKYTATLLDIYKAGEAAAERDSEITFIKKTTCSNANLEKRKQYLIMGKEALQIKHNFRLKNGEDRICPKCKG EDTPSESPGSLLSQEKGSPKFMEEHEVTSQAAHLNLLLGFMKQWKAQLGSGLGYGPIALERNLSDLQLQGAVEVAGDLEV DCYRAPCSESQEELALQHFMKEKLLTELEGKLCVFENIVAVLNKEVEASHLALAASIHQSQLDREHILRLEQRVLELQQT LAQKDQALGKLEQSLRLMEEASYDGTFLWKITNVSRRCQESACGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGTGKRTHL SLFIVIMRGEYDALLSWPFRNKVTFMLLDQNNREHAIDAFRPDLNSASFQRPQSETNVASGCPLFFPLNKLQSPKHAYVK DDTMFLKCIVETNT >XP_041428292.1 complement C5-like isoform X1 [Xenopus laevis] MIWLNVALLLALHGYCLCQEKTYLVTGPRTWRIGALETVVVQAFGQHGDFSIRINLLSYPDKKITYATQHLVLNNGNNYQ GLVKLMIQPQDFPKHSASDPMPFIYLQALSNAFNKEEQVPVSYRNGFLFIQTDKPFYTPDQSVKIRVYSMDEELKPGRRK VVLTFKDPEEVKVDTIEEDDLTGIISFPYFKIPANPKFGMWSIEAAYGKDFTTSGTVKFEVKEYVLPKFLVSIEPEQNFI CYDKFTEFYITVRARYYYEKLVENAKVYIRYGLIQDGERKMLPKSIDLLTMNNGESVFQLNSQKALQELGYSSLEEVAGS YLYITVSVEESTGRVEESENADVKFVLSPYTLKLVGTPLFVKPTLPYYIKVQLRDTLDKPVGNIPLTLSGDMVKEDGSPE DLIIQQQRISTDRNLGIGLFILNIPSDIVSLDFTIKTDDSSLPEENQATATHVAVSYQSLTKSYLYINWAREREVLHVNN FLNVQLVPNSPYIAKLNHYSYLVISKGKILQFGTVPRVPGSNSQSLNLHITADMVPSVRLLVYYIVTGDATAELVADSIW VDVVESCVNHQSVQLSKRENIMKPGQTFSLKISALPKSLVALSAVDTALYDVGKRFQRPLETVLRKIEESDLGCGAGAGE NNADVFRLAGLTFLTNANIQASQKYALKCNEVLRPKRSFNFKDEVDKKASTYTDRNMKKCCYDGVKCFRDENDCAAGINR VSKRYSKKCINAFEVCCLFAKSLQEKMDAQIQDVGMGRMYLRTVFDIDEPQIRSYFPESWMWEEHLLDNRGEKTLSVTLP DSLTTWEFQGVGMSDKGLCVADQFKVTAFKDFFIDVQLPYSIVRGEQIQIKVVVFNYRNSDAKGCVTVSVGKEICLFSDT SPRSGSRECYKHTLSATSLTPFTFSLLPLEVGLHPISFTLSSSSQETVKKTLRVVPEGIKKERNAGFTLDPQGIRGVARR RQEISYKIPSNIVPKSKVSRILSISGNILGEVINTVVKSEGINYLVSLPKGSAETELMRVVPIFYVYHYLETNKRWDLLG TNILAAQIDMQRKMRDGVNSILSFRGKDFSYSIWKEGKPSAWLTAFALKIFGEMEKYVYVNKMSVCNSITWLLDKCQLRD GSFIDQSGYQPGKLQGTVPSESEERSLYLTAYVFIGIQKSFHMCPLEEVKEGLRRSEEYLSKNIRRAKSTFTLAIMGYAL ASWDVSLASVRYVKGALEREAYVIESGDLPIQRYWKDSLKKVDATTPSVETARMVETTAYALLMYLKLALKDYYNPVVRW LKEQQRYGGGFYSTQDTAIALEALTEVSIVDKKLTLNMGVQVSYKKSGDFKNYRLTETSSFTRPEEVPLPEDIIVSTSSA NGIASVHVQTVYNIISPPQEKCRFDLRIGKKLNWKPRQSIFDSERFGVIPVEACARYKAADNDPSISGHAVMEITMVTGL TVDENELEELMQRVDQFVTAYDLENGKVMLHFDGIPSDEYVCVTLLAWEQFKVAVLSPGIFSVYEFHAPEEECTTFFNPL TTNNLEKLCTGDKCKCIQATCPTAQRKIDTSITANARREVACKADVTYAYNVLVISSVEDGDFIKYTASIQDIYKKGGDF VKAKKEVKFIKKKTCTDIEIDQGEHYLIMGKEGIQIRIGFEFLYEYALDSDTWVEWWPPACNTAACEQFIDTLSEFSDKM LFDRC >XP_038046848.1 complement C3-like isoform X1 [Patiria miniata] MQAFLIFFAALQMLVTAQAAQYFIVAPNLVRVDVQETILVSVLGTGENQIPVTLYFQLTGSNDRISETTVFVRQDESQEA RLRIRRDQLPQLQTSGQQFVTLVASANTAQLSIDDRRVILLSYQAGFVFIQTDKPLYTPKQRVDIRVVALDQDMVPVNNE MQVDIISPDDIIVERYKQRPVDGFLTLSFVFPSNPVFGNWSVSAYYGHQFKASSTVQFEAKEYVLPKFYVEVAPQSLYIV PETQNLISKVTARYIFGEPVVGNFYVKYGVLEDDGSLMDLQSKEGRLNEVGEAFQDLDMNDVKVENWAETLMGKRLVIQA FVTDTATGETINTNNTQVTFSRTPYKFNWDLTQRYFKKGLSFSVKANVQFMSGLPAEDVPVIASATALQGGRRVDLEGAQ AGAQAGGGREHLEKISGPQGEVDFRLDVPAAATEITITLRTNNPDLVNANTEGTITVLAQASSNNEYLVVRVPSGDIRRV QRIGRQSTVEVQLTHPDNVGVLNYFVIAGGRIVHKGAKNQVNLNTALGFEVTHEMAPSSRVVAYYTDANGNVVADALLID VEEKCKNPIGLSFLGLPSEGSTYKSERSGQNVQLEILAKEDTNVGLVAVDEAVFKLRNYHRLTQKKVFKRMAGYDLGCGP GGGQTSATIFKNAGVTVMTNAQLDVPHREALGCPEPVRRARRSANDTEREQILSNYEGVNREYCEKGMRELSGSVQLTCA QRAKLMAGRKGLQVDSPEIRAFFDCCSVLESSSDRGRVDAGAGGVNLEDILVRSNFPESWLFDNVITQSLRSDDDDGRVL YPTTLPDSVTTWVIEAVGVHMREVHEMCVAEPIKLEVRPPFFLDIGMPYSVQRFEQIEIVASVFNYGDDELEVTVYLRGK EGLCSIAQPGEYSEGITIQVEAKKPASVKFVIVPLEVKNIPIEIVAMDASGQHRDAIEKDLTVRPEGYEKKISVPVTLDP ANYRGSPAKQDGGADQFYFHSQNWGDQGEEKQIDFIRYSVNRNAIPGSHKARMSLVGNVLGSVIDTVLGGLDKLLRIPGG CGEQTMLGLAPNVYVYTYLKHTDQFTAALETSSERYVFNGVKHELTFRKNDGSYAAFTSRPSSTWLTAFVAKIFCKAKDF AFVDDSNICKAMEWLITQRQSQDDGSFTERNAVIHKEMSGGVQGKASMTAFVLISLLECECDAINKDDSVAAATALLEDE LPDLTRPYAIAITAYALALANSIRAQEAIQMLKDIAAYNAVSDSRYWAADDSSFGGGQKPYWYSARPKAIEVETTSYALL ALLQMEEIQYTHAIVNWLTNQENYNGGFVSTQDTVMALQALSEYAYKVQQYDIDINCEVKCDESEFDEDFSLNPANALVR EQRNIDVPDMSQEMNVFISTEGAGMGQFKFEATYYIPEPDVTECDFDLLINEDENLQLDRPEDDNKEYLSYDIQVRYLRG EKTGMAILDVGLYTGYKAVQEDLQTVMDNSGGRVERYEETDHSVVFYFEDIPGLEAIRIQFRAEREFNVGKVQPVAVHVY DYYNPTEECVKFISPKEGSNLLGKLCVEDTCVCAAGKCAVDPIKKGRDYKVYDMTQMACASKAHFAYEVTVTDVEDKGNF QFYTMTIDAPLKQGLDHVVKDATRVFAKSKSCDTPDLQMTKYLVIGSGGLPTKDDVGQDIYKYVIDDRTFFYEYPTILQV NKSKKWQRIHAKLTELKQELVNGEGCAL >XP_011661993.2 complement C3 isoform X2 [Strongylocentrotus purpuratus] MEGLKGLIVAIFASMAVLVYSGSAQLQTREKIFITAPNVFRVGVNETVTVSVFNTDQDQDVEVTIYLEKRERTRGLAWPY SYTTVAVRRGTPVTTSVRVEPEHYSSPAEGGNQYVYLVASAPSLGFQEEKEVLLSSRSGYLLLHTDKPIYTPNQEVKIRM VVVDQDMKPSSELIHLMILNPQGIIVEQFRETRAVNGFMNKTFTFNTEPMFGNWSVTVLHGLQFEKNKTIKFEVKEYVLP RFTIKINTPDFILESSSRESLDINFEAKHVYKKPVGGNFHMEIGILQPDGIVVSKSTTVGTLENGIGTSSIYPRYNFGLD WFRSYEGCRLNVEVVVTEASTGVTERAVDISTMIVRSPYRFRTGQTVQYFKPALPYEVQFELETVLGKPAQYLDVNIEAS ALVQSRRLTLNHNMDPNANQQSTDANGRVRFIFNTTQDMSQINIRVSTEENIEQENAVFQFDANPYQSPADDDYLSISID QTVFRVGDELYVVARTTASTPIDNLNLLFLSQGKVILAKSIDHMINNPERVFFSVSSDMVPMVRIIAYYINQLDQVVADS IALKIENTCKHHVAINIKEETNEEGAYLPETPVTLLVDAYPTSYVGLLGVDKAVYALNNKHRLSRKKMFEMMQTYDIGCG PGGGPTSPVIFKDSGLSVLTNALLAVPAREALTCQRVSSSRRKRSATQCQSNSRSRIEYCLNQLERRCNCDDNLTTTKMF NRIQRWCTCETIASKLASKLPPYCPQATEQDIEDFSQCCELMNKWRIGSAPLGVDVLDSMDSISIGEDSTDTFEEFGMDV RSDFRETWLFDLIRVGAPGRASLDLQTPGSITEWSLQAVSVTPTGGLCVTDPLDVNVFKSLSIQLQLPYSVVRSEQIEVL ATIYNYNAQGATVRVSFYNPKGTCGESTNPSQPARRTVHVEGFNSQSLKFVIVPVEIGDLPITVTATSDVGSDGVQKILN VIAHGVPQSVDHSVMLDPSGIYRQQRRSPRLRAAMMEDIQSDLLDTDNGVQYNILDLRPPENIIPGTESAVLSLIGNMLG PILVDPVANYGEWLAYPRGCGEQTMSIVAPTIFVLKYLQTMKLMNDSLEEMAMDRISRGLASVLSHRREDGSFTIWGTNV LYSSSTWLTSFVLKVFSHANTLTPVDENVTCKAAEWLVLNAQNPNGSFSELYKVHHTEMTGGISGEASMTAYVLIALYEG HWCDGMHRDFPLALRNAQSFLERQVKYLSRPYAKAIVTYALALSRSAYASDSNRMLRNDAIILGDGSRYWTPNEADLTNE DLPNWYRFRPSAIAIETTAYALLAQLELGDITYAGSIALWLSEQQNYEGGFISTQDSVLALQALTRYSEMANGGIDIDLS CVVTSEVDESFHYEHRFLTHNALVKREVAVPVGGRLRSRCEGKGTAKLAVRMKFNRLPSSQDVCPFNVTYNAREARTGMD PISISRSRVGIAPRSTTTSAQMARAKGDLVATIRFCARYTQNTRTNMGIIDVGLYSGFVLVSERLEDMVQTDHLHLVQRY EVSQRSVIFYLDEIPADQDICMEFNARREIHVGNVQPVAIRVYDYYSPDKSCTSFYHPLQGNTQLPTLCNSADQCICPSE RCALCTREPGKSLLDKACESSDNYALRVTMMSQERISGYTVYIGNVTRVVRTGQDDVSPGMLRHFYIKERCPCPRIKLNG EHTIIGSAGLSFISDTGADGYKYLLDDRSIVEWWPTKLNKKKNLDIQTKLLNFEQDAQLCT >XP_031565662.1 complement C3-like [Actinia tenebrosa] MITQFKENAMFTDSKMLLTLLTIALLMVGCSSKPSYVITAPNIFYVGVPQPIHVALFDVKWSHTIELELRVFLSYGETKV IASQRDRISADNGKLFSLTVGPEVSKFQSSQDRGFVYLLSRIKGPELHISKNTKVNVSYSDGVILIQTDKPIYTPKQTVK IRVVPLGFDLMPSAKKINLVVKNPHGIGVRQWESLNTTLGFISKNIDIGSYALAGIWTIEAYYGHQFLYNASSRFEVREY VLPRFSVKISNPLYILPTLDSFKVKGTAKYTYGKPVQGTATVRLSIAGNPQEKAMSLSTSKIKLVNGEFEHPIKMDRIKT KLREKWFPEGYRLHIEADVTEKSTGKTERAVERSVYFVTTPYLIEYVNTARYFKPGLPFSIVVIVKFTNGQVARKIPMKV LVEAFKTDGRKINASDPKQIQGSGFNWNRANTDDNGRAEFVINIARQVKELQIKVKTNLQNIPKEQNAFKELVMDASESH ELMKLRQTNKPARVGTNAVCDAVLTSKTVDQLTYFVISRGQIIYSATIKKLLGIITTISFKVTSPMSPSSRLFAYYVSKE TGRVVSDSILLEVEHKFPNPIFLKDSDRRNEEPPSMPYNIKIVGTVGTKVGLLGVDQSVYLLSKSNILTADSVFKKQEEL DLGCGAGSGRNSEDMFRNAGMVVLSSDIEVSGEQKCKGEHKRERRSIEEHRDFCCSLGNKTDTIKRSCFRRLKDLDVGIY NAKQRYDCRKTFWMCCIHKFGRNESGIFARARSGVDLEALDFGDEQQEDDALNIQTRQYFPETWINKELTISQHERNGEC RALLSQELQHKCGSAVLPVSLPDTMTTWVVQAIGVSSSAGFGIAKPLHITTFKPFFIYLSMPYSVQRGEEITILATLFNY KNYDVSVHLFLKGDQGFCSAAQPGKMTKLTTSKINIPPQDTVAFPITIVPIKFGKVPIEVIAVGDIGDDRVLKTLNVVPE GIEERLTQSYVLDPQELLKGRKEREENQQNKAEKLSFQSTQAHKDFKQKNKIKLDIPKNAIPGSISAKAYFTGNMIGQAL TNLAAGQMVSLLQMPDGCGEQNMVRIAPNVYILHYLKKTNQMTPELEKKKEKFIQEGYIHELNYRKKDGSFALFKREYNK GSTWLTAFVLKVFCQASKLSGVNIDRNVLCQSAKWLIGNQRQDGAFVEHANMRSIQGGVYTSDVTLTAAVVIALKQCQCG MAEVNSAVERAVGFIEKNVTTLADAYSLAITTYALVLANSPERFRANQKLIQKATYNQGSSNRYWETGSKARNIETAGYA LMAQVALNRFEYAGPIVVWLTKQRSFGGGFVSTADTCVALESIAKYSEQRQKFQLDLRIRMKNKIMRITKNNAFMQQEAD LTEQTGDEVGIQTSGSGVGQMQVDIKYNVPYKENERCDFDVKVIATEEGSGRFISTTSSARNNVPARSRSRRALKAKSAK SKKRKDKNQAKKGKPGKSKKNKKRRKNNRKKNQKKHQKKNQRKNKRRNKGKSKKREKNNRKPQSIDIPKKLVLRVCTKYR KSGQTGMAIIEVGLVTGFSADEDTLIKLVEKKNNSIERYELSDRAVVFYVNQIVNSRRICIAFHLIRIFDVGIIQPVPIK VYXYYEPDTKCTLFYNLGSKRRPVGSCKKEKCKCTQGMCAEPDPYINNIDDLINEVCNVYNYAFKGKVVGIDENTDTNPM AMTYQINITQIIKQGSSIFQTQKAYLFNKPGICHYPDFEFEDEVFIMGKNKNGVQFLDRDTFVKTLSRRQRFVNKIAKHI RHGKCT >XP_039271128.1 complement C3-like [Styela clava] MKLLQLCMQLFIAVLCTRTSFGQNHLLIAPQILREGVRETAVLNLYNIDGRIDVVATVKLEGVTNFEIKNEDATKPIIMK IKYDKPPGVLPSKRRQYVELLVSAKQGNKKVYSGQLRMRLIESSGYIHIQTDRPIYRPEERVNVRVIALTQTQSPEVHRE VEIVIRIPLDNVGVEKKLLRMPKAKFIDTSFELPEYPVYGIWSIQARYTDEKVVRWSTTTFDVRPYVLPTFNVRVLLDDP YVLVKTDMSNEYIRGTITAEYSYGRKVSGPYFLAAKLNRPDIKSKFLFYQMPELRRMAKLRGGKQRFEIKATEVLTVIGD DTFDDLEKEGATIEIDVAVTGEAEGVVESDRSRPIMFVRSPYQLDISRMSKYYTPRTSFEIKIDVLDSVTNSPVKKVELI LAGPKICGTLDCGNDKCCSNGKCGECEPIVEESDENGQVNFKIGMDKDPVKRTYTIQTRKLGIPRENLAKLDFTLHPYIS SSGSYLQLSAVEKIAEVGDKNFGIDVWYKSAPSRISYVIMARGAIISTGVHIPKKGSVNTNIKIEVKGEMVPSFRFFVYF FSGKELLSNSLWIDVKDACKQELQVKVPAQVSPSQVFNVEYIGSPNAILGMSAVDRAAYFLYDKGRLTRSSVFEALNLYD EGCVREGGKNAQHVFEEAGLQVVGGPYSAKDDFTNHCEAKTLKRKKRSSPKNIVAKLEKEALERKCLMDGSWENLYGTSC VERAEAVRLKHSFECAEKFLKGCEDYLKLKRRSGRSIQANVAGFQAVANNVRSNFEENMLWATDVILGPDGKYTRGVVAK DSITTFEFDTVSMHEIDGFCVAPTQNVTIFKDTFVQLKLPYSLKRMEQAEIRATVFNYATTSKRVTVHVKMGEDICSHFR QGKFDDVITLEVDANEAEATSLVLMPLRVPDSKQVDIEVKITNEDNVDIDHVKRSILVLPEGEIKNDIKGTYAIDLKNKR PSYIDRFKIELRFPKRYIPGSRQCWIYPFSNYMGPIIEFDPVTKQPKNDIKNLIRLPGGCGEQTMLSMGPNVMAHKYLKL VGKMKDGSAEETGSIDKMQKGFANELKYRTSTAPIVWSVFPRRAPSVWLNAYVNKIFAQAKQFYTAMDVGPICTSINWLV DQQNPDGSFDTGGRVIHQEMHGAVGSTLSLSAYVMMSLVESQSICPQYTKKVEISILKATDYLENSENDRQMEQPYALSL VCFALSVSNPNNPFAKRMRKKLLSKINYSEDNRLAFWKGAPLKTIEGTGTHAYWYKRNAKAIDVEATGYALLSILYAQSG EKVTQNILDVTRKIVLWIIQQRDEKGGFSTTQDTVVGLQALAEYMIWSSTVEPPTRDVKIDLTISSATGSDWYDEPKRLH LDKSNENSTTPISIPSNVISGGELNIQARGEGEGTLSYRCVYRTLVDEDACHFDISVSTEEDRIPLGHVAQGDGAEILKL KLYISKPKGEPSGQSIVEINLISGYEVMEDTLVKLSETVDASIERYEIAKQKVFLYLSDITEVPKKLAFRISRSVYVGRP EPSTVTVYDYYEPSVRCSKFYNVPEQNLKLRTSSCTDKNGLGSEDICKCAEGGCLTCRTRKQQLENTGCLEGMDGECTIC HDPDNCFDLAGTACKSDYVYEVKVTSDGVEDPSGVFMDFAIQIVEVYKAGDDLDVDRNQNRNFSVRRDCFESCRDDKALV DKDGKKEPFLKKDRTLLMIGNGVEMNYEDDDNILKGGELPRPHYRLGAGIFVERIYPTTKCKKSKKKAEEKKCRKLKKKT PKSTREECLKHIAIHQSCNNLILLRKRITLGCDRERK >CAE1304902.1 unnamed protein product [Sepia pharaonis] MTNVEIQLKGSPRATVGLSAVDKAVYLINDKNKLTRKLVKDTMKLGDLACSPGGGLHVGQVFYHAGFVIMTQDLDRTPAT EINNILCSLKQITAEVSFGRYRRASDFCCISGRYRRGHNCKVAWQEFSYYRKTEFCRSAFMQCCNPAPELPPTRKVITSG EVDESENERTPSARLRQDAKSISPIFSLYFPESELFQEYRLNPSGLHKLNFTLPDSLTTWHIQGMSLSDTSPFCVSKPIS LTTFKNVITKLNFPRVVKRLEQIYIKAVVYNYKTHPINVKVNFHETKEICSHAAPGKPFPVKLSIPAKDIGVAGVVIVPL KAGNFTIHIEVYEVESNTLEIIEKVLHVKYEGVKKTNSFSLMLDPSGTYSGHKRHRRHIFKDVTIPKNEISASQKMQRII MKLTQPAEAIDGSAKGDIVITGNILGSTIQTTLKEPHKLLDKPYGCGEQTMIFLAPCVYILSYLNSTNQGSQVIYENATR YIRLGILREQEFRKMDGSYAAFDQNPSSVWLTAFVLKVFCQASEFEHVDSHLTKSAMTWLFQKQRLDGSFIEDYPVIHQE MVGGVNDRVMTAFVLISLMECGYKMHPVEIYRRKNEIDLAIRYLEKQMAVTYDTYDMAIISYALALADSSRKYEARIKLR SMAIENYDKGYLYWRVGGYSNVTAKKVSAWYHTEESYLSVEATAYALLTEMHYGEVEHVGPIVKWLIEQRNSAGMFKSTQ DTVMALQALAEYGIKTITPDINLFFNLTSSRAHLHKHLTVNKETSLWSHIIPDVPMNDEVLIESMGIGSAQMELNMWYYR PPTQRETCHFNVTHIIMPIQKDVRRLIKRGCPLCGESCRNLNGPILRNWDVSDQTICMKIYLRYLGTSDPGMVVLDMDLL TGYDTHEELLEQLKLDRLIAKYHKHGNSRLTLYFNTIPFNKEIEIKLLMFRTMIYMNRLMPAPINVYVYYNATESCTKFY QLSREKDLINLLCDSSKKVCKCAQRDCVTCYESMSELVNIKLKFLEKKSCAKEQIVMIVNMTSTFDSSGTAYGFVQEDLS KTDIPDLEEHVAIFQKGICHCPHVKVGEIYLIMANKRVRTLDESNQYRHKFWVDSSGLMINKKNQFVKGEIDIFEQKARS LSRQAFCG >XP_006565503.2 alpha-2-macroglobulin-like protein 1 isoform X1 [Apis mellifera] MNKLVFLVLFICSVTFLHCCDAASNVNRGYVFTAPKKLYAGEIETGCLSLHNLELPAHVHLELVFSFLEGQEVLASTSAV VKTGTETCLQLAVPSPIYRTAILRLKIKFDKYPDYVIKSETDVEIEHDSLLTFVETDKPTYKPGQDVKIRILMLMHDLKP WQKSIPEVWIENPSFVKVKQWTNVSTENGMAQLTFPLSPEPSLGSWHIKVMKKKPYPNLIHSTTFKVEKYVLPKFQMTIN SPQYILANVENVTWNICVKYSYGKPVKGNLLLKLTPQTPSWTRLPNLPAIRYETKLDKGDGCTDFVLSGSVLGLAHWKMD PNNIVLIAEFTEAGTGIVETTISRTVVLHEALKLEYEHYTPKYFKFGLPYHGKLRVLRYDDTPAPNEKIQICLKVRGKIE WEKDVVDCRDFRSSTDGFVDFVVPPQHKNIVLLSFVATAVDYPTTYYSPEQRWRVFMNQPSTSITVNPWYSPSDSYLTVA RGNQPIVCGEKYSFNVMYTTSSNMNETISFHYSINSKGSILIYGHVKHKPNRDTILNYFEFHNLLGTIESSANKTNKEAI VHRFPLSVKVTPSMAPVSELLLYYVRSDGEIVATTYTIEVGHCFENKVKSTWHTDAQIPGSPTQYHVEAAPRSLCAISAV DKSTLFLSKSESNLMSSTQTFDALKRFHPTPKFYFPWENSRCKSAIGPEEMKEEINHLPQFLRSKRQTITYSKRVNYVDA VQAFVDFGVIVMSDLVLETRPCPWLFMEYTALSRQYISTNEYMSMKDNSEFAVAAAAMDSGIGYVDQNQAQMATLRSYFP ETWLWELVPIGEEGKITIERTLPHTITDWVGYTTCISPTHGLGIAPPTTITAFQSFFLDYNLPYSIKRGEIMRFKVSLFN YMHHSLPVKIKLEEMEKIDLHLSEPTASFCVKPRDNIVHEYILKPRVIGEVNITVTAFVDIDYPEPCGSETVIFTQDVIV KPILILPEGFPVEETKSALICPKDSSDDSSFMWELTLPKDAVPDSGRAYLNLIGDILGPALENLDKLIKLPKGCGEQNMI LFVPNNHVIKYLDAMRINKPDLRAKAIRNMEKGYQRELKYRFMDGSYSAFEEGESSIWLTAFVLKSFAQAASLIHIDKYV LESSVSWITMNQLEDGCFPVIGTVFHKSMKGGLQEHGSSSALTAYILISLLESGVPLSPSVVNDAQKCLEKGMNNDDLYT TVLTTYVLALLEHPKANSSMKSLMNRATRYKNLIWWEDKSKPSIGLSIEMTAYVILTLLKLGEENLSEALKAVRWISKQR NSEGGFTSTQDTILGLEALTKYAMIVHHNNITDLSVLVTASKEVDDVYKLQDENRVILKQIRLPILPTIVEIFAQGEGCV LIQSNLKYNVASSTGSDAFDLSAEVRSVGYGNECSLQEITICSRYKMADEESNMALLEVGIISGYVPDRASLHSLLDPSS KVKLFEEDQDIVTIYFNKLTGQKTCISFRIIQEYFIDHLKPANIKLYDYYQQELTVSTNYKIPSICSSAEPVDEQLTTPN EMIIMKQLSFDESPMNSSFVVNNAELAIPDGMEGPIPVYVKLNTYDYKTEAATTTNGLPDLTSTFVTEDQTVPTVQTEDE EPIRIDTDNPSITNPLMKEVLRIVKILKINETNVPSPTRINQSCPICMDVLPSNISDIYCSANSAVKVAIRRFRKVRLLL DLHISREVKRLRAMIEFTLSPNCSCSPLDNPGSFALIINKDNDFLTSGNQKQTLNDSFYIYGLPLVSGVPCKLAEIRASC LNEDNIQCTYEDPPAYG >NP_001366904.1 TEP (ThiolEster containing Protein) [Caenorhabditis elegans] MRLLILNILFVVWQIHGVIGQSTNAAVVSTTAAPVKPATYMLVAPAVVRPDQPFSVCMNLLKQATDEDMIVRIEVRTERN ETIAARVISNLKPGIAQTVSLSEMPAQSLTPRQSYKLYIRGETLNAELIFENENELKYDQKALSVFIQTDRAIYRPASLV RYRAIVVKSDLKPYVGNATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGDWFIEVETSNGVQDKSSFTVDTYV LPKFEVNIKTSSFITINDDLSVFVDAKYTYGKGVAGKAKVSLELPWHRWHAMVPTIIDENGVKKEEELMVERTVKLNRQG EAAVVFSNDELKRHKLLHEWGGGSIRIVASVTEDITEIERNATHQISTFREEVKLDVEKQGDTFKPGLTYNVVVALKQMD DTPVKATLPKRVQVSTFYNYPYNHDTSSLQEEKETKIVEVDAHGTSVLTLQPPINCTSARIEAHYDIGGKDNFTATPIYS SLYVEAAVSPTKSFLQLLADNEGAVDVGKSLSFSLKATQPLSTITYQVMSRSNIVVSQQMTVNSEHATISFPATANMAPK SRLIVYAIIESSQEVLVDALDFKVEGIFQNQVALSIDKQAVEPGQNVKFKVTSDKNSFVGLLVVDQSVLLLKTGNDITRE KVEQDLENYDSNNVGGGFGGPRPWEAIDRKKRSIWRPWWGIGGSDAQSIFSNAGLVVLTDALLYREPQREFMSERRLNTP GGLTVMMMDGAPGMAEAAFAAPPMGGSSPPPPTVRKFFPHTWIWSDLNSTSGEVEMEIEAPDTITSWVASTFAINEENGL GVAPTTSKLRVFRPFFIQLNLPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDKDSGYDLLKKDGTVVRRDEVGQQNVR IVSVAGGGTSKAVYFPIVPSSIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVDRNIPFVIDLNNNSSDFSKNLELIWPN DVVDGSQKARLDVIGDMMGPVLNNAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELT YKRADNSFSAFGDSDKAGSTWLTAFVVRSFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEVHHKDMQGGAQDGG VALTAFVLISILENGMENGKAVTYLEKHLDEVSGNAYTMAVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKFASAQK KVEKLKESRAYMFQARPVDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSYAAVTYSDK HTSQVTILNGKHTHSFDINIRNAIVLQSYQLSSLNDAVSINANGTGVVFAQLSYSYYRDSLNDDAPFFCSQEIKEIRAGN RLQLDLCCNYTRPGKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEMEKDDTKMNVYFNPLGGRPVCLSLYSDVTYQ VADQKPANFRLVDYYDPEEQLKMTYAAKQTRSLQEKCGEDCWPPISPSLPPFDESTVTEIY >NP_523506.1 Thioester-containing protein 2, isoform A [Drosophila melanogaster] MFRIFLTGIILQYALLVNATGIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSYNETKQIELPPMSTQNVEFE VPKLATGNYNLSAEGVSGVVFKNSTKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISVIIIDGAQ NRIKQLSDVKLTKGVFSGELQLSEQPVLGTWKISVSVDGDNRETKSFEVDKYVLPKFEVIVDTPKAVVIADKVIKATIRA KYTYGKPVKGKATVSMERSYGYFGDLNANGNKQEKTIDVDGKGHVEFDIIHWAQRGQYLPPIKLFAVVTEELTGNKQNAT ATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKIGFDKSYSYFHEPSPKTRINFEAPVNENGIA TFNVRLPDSDSRYYRIFASFDGSENTIGSISKFEPTPMSREPLKIQVNTKKPRLGEQVSFDVVSIEDLPYFVYTIVARGN VILSDYVDVPDGQKTYTVKFTPTFSMVPKATIYVYYVVNNDLQFEEKTIDFEKEFSNSIDVSAPTNAKPSEEVKLRIKTD ADSFVGLLGVDQSVLLLKSGNDLSQDDIFNSLNIYQTSTPWMNGYGRYPGQTSGLVTLTNANYPYNTGPLVMSYVFEGSR HPWITRPRYRVGIRGDSGDRISFLSQSLNDRNLKEILLKQTPQRTTIRKEFPETWFFENVGEEEFTLTKKIPDTITSWVV TGFSLNPTSGIALTKNPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEATNEVLE KAIDEVRRVKRVTIPANSGKSVSFMIRPKNVGFTTLKITATSALAGDAIHQKLKVEPEGVTLFENRAVFINLKDQPEMSQ SLDADIPNEVVPQSEFIEFSVVGDLLGPTLQNLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGRKLPSVESKARKFLE IGYQRELTYKHDDGSYSAFGKSDASGSTWLTAYVMRSFHQAGTYTDIDPKVITAGLDFLVSKQKESGEFPEVGKLFDNAN QNPLALTSFVLLAFFENHELIPKYQSAIKKAVRYVAEEADKTDDQYSLAIAAVALQLAKHPQSEKVIAKLESVARKENDR MWWSKATESTGEDGRVFHWKPRSNDVEITSYVLLALLEKDPAEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAY KTGSGSGTMDIEFSSAGESKNTIKVNPENSLVLQTHDLPKSTRKVDFTAKGTGSAMVQLSYRYNLAEKEKKPSFKVTPTV KDTPNQLLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVETKNSDSTVVVYFDSLTPGD VRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVKSSLCDICEGADCGEGCKKD
Mafft alignment of selected proteins >sp|P01031|CO5_HUMAN Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 -----------------MGLLGILCFL------------IFLG---KTWGQEQTYVISAP KIFRVGASENIVIQVYGYTEAFDATISIK-SYP-DKKFSYS--SGHVHLSSENKFQNSAI LTIQPKQLPGGQNP--VSYVYLEVVSK-----HFSKSKRMPITYDNGFLFIHTDKPVYTP DQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEEIDHI-GIISF-PDFKIP SNPRYGMWTIKAKYKEDFSTT-GTAYFEVKEYVLPHFSVSIEPEYNFIGYKN---FKNFE ITIKARYFYNKVVTEADVYITFGIREDLKDDQKEM------MQTAMQNTML--------- INGIAQVTFDSETAV--KELSYYSLEDLN--NKYLYIAVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFLKPGIPYPIKVQVKD-SLDQLVG-GVPVTLNAQTIDVNQETS---D L-----DPSKSVT-----RVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE-------- ----NQAREGYRAIAYSSL-SQSYLYIDWTDN--HKALLVGEH-LNIIVTPKSPY-IDKI THYNYLILSKGKIIHFGTREKF-------------------SDASYQS----------IN IPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DAD- AYSPGQTVSLNMATGM--DSWVALAAVDSAVYGVQR--GAKKPLERVFQFL-EKSD---- --LGCGAG----------------------GGLNNANVFHLAGLTFLTNANADDSQENDE P--CK--------EILRPRRT---LQKKIEEIAAKYKHSVVKKC-CYDGA----CVNN-D --ETCEQRAAR-----------ISLG----PRCIKA-------FTECCVVASQLRAN--- ----------ISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVP---------- ----------RRKQLQFALPDSLTTWEIQGVGIS---NTGICVAD-TVKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPV----IDHQGTKSSKC VRQKVE-GSSSHLVTFTVLPLEIG-----LHNINFSL-------------ETWFGK--EI LVKTLRVVPEG-VKRESYSGVTLDPRGIYGTISRRKE----------------------- ---FPYRIPLDLVPKTEIKRILSVKGLLVGEILS----AVLSQEGINILTHLPKGSAEAE LMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYS--YSVW K---GGSASTWLTAFALRVLGQVNKY--VEQNQ-----NSICNSLLWLVENYQ-LDNGSF KENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI----CP--LVKIDTALIKAD NFLL----ENTLPAQ-STFTLAISAYALSLGDKTHPQFRSIVSALKREALVK--GN--PP IYRFWKDNLQ-------HKDSSVPNTGTARMVETTAYALLTSLNLKD--------INYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLRL-SMDIDVSYKHKGA ----LHNYKMTDKNFLG---RPVEVL----LNDDLIV-STGFGSGLATVHVTTVVHKTST SEE-VCSFYLKIDTQDIEASH--------------------------------------- ----------------------------------------------------YRGYGNSD YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVD-QLFTDY-QI KDGHVILQLNSIPSSDFLCVRFRIFE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SN IK-IQK-VC-------EGAACKCVEADCGQMQEELDL----------------------- -TISAE---------------------------TRKQTACKPEIAYAYKVSITSITV-EN VF----VKYKATLLDIYKTGE---AVAEKDSEITFIKKVTC---------------TNAE LVKGRQYLIMGKEALQIKYN-FSFRYI--------YPLD---------SLTWIEY-WPR- -DTTCSSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGC-------------------------- >tr|E7FCV2|E7FCV2_DANRE Complement component 5 OS=Danio rerio OX=7955 GN=c5 PE=1 SV=2 -----------------MARLLLFCIF------------NLFV---CFTVQENVYLITAP KVLRLDASETVVVQLFGFDQETTVHLHLKNTLA-VGNKEYD--YQSLKLNAANNYQASAT LRILAKDFPKEDTS-----VYLQTISS-----AFTDNVKIPVTTVNGFLFIQTDKPLYTP EQEVQVRVYSLNEELRKS-ARTVTLT--FQDP-RGVKVEIIDMTDIN-GAKPLLPPFKIP LKPIYGIWKIVATYADNFETT-ATAEFEVKEYVLPSISVQIEPETNYISEEN---FDTFK LKISAKYVQGMPVKSANILLKFGY---STPEETVI------IPSTYRSYML--------- YNGKMEVDLDIRSALSSKPDAPQFLNAMK-ENTFLYVEVLLQESTGGLSQEAVLSHVKFV ETPFTLSIIATPPFIKPGLPYAMRVLVKD-PLGEPVK-DVSVTMRATATTVDNLSD---N LKFLGHQDSVTVP-----SSKDGVAYFTCNIPANVKNAEFTFETEDASW----------- ----SQGPLTLKAESYVSV-NHRYLYIDLPPE--SSVFEVGQY-VDISVVFSYRD-YLSL DTFSYQIISKGKVVKYDTVKRV--------------------SEKSQS----------LN IKITPDMVPSARLLVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTL----KLQD- DYKPKDKLEIKVSSRSKGESLVAFSAVDTALFNLRT--NKKDPLKKILQHV-EKSD---- --LGCGKG----------------------GGKNNADVFDRAGLMFITNANAKASS-AGG T--CS--------DTLRPKRSV-DLKKKFEDKAQKY--GAFREY-CLSGT----RSSPTL --ETCKDRANRVTLPNKKTRRDYEKE----KYCRLA-------FEQCCVFAKDLRKE--- -----------NAENIILSRAAIDFLMDAPLSQVRSYFPESWLWEEHLSKS--------- ----------GSVSISKTLPDSITTWELKAVGVF---NEGICVSD-K-RIPVSQDIWVDV PLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLTASSAVCVFHGAQ----QGKP--DKTNE NSGQVA-GGSVAMVSFYIMALEAG-----THTLTFTL-------------TTDWIT--ES VVKKLRVVPEG-IRMEEYIGKRIDPNGVFGTPMRKLE----------------------- ---FKNVIPPKIVPKSSVDRIITVNGEVLGDILS----ILNNPEGIKMLTNLPRGSAELE LMSLLPVYYVYHYLDKTEKWNILGKEAAASEKELKRKMQAGITSIMSFQLKNGE-AFSMW AQK-DKTPSTWVTALIIKTLSDIHEY--VYVDT-----DVLANAIHWLIKNCQ-NEDGSF SELAKTNPHKLMGAG-VGVTEKSVYLTSYVMIGIKNALKIPN--LK--LQVFKDALDRGM QYLISRFRKSSHKIE-SLYVRAIASYAMTVADIDDGTAVNVYENIKKKAKID--GN--PP RVCFWQESDT-------NIDPLKPSSVTAKSVETTVYVLLNTLTRGE--------TEYAK PILNWLTQDQRYGGGVYSTQDTILTLEALTMYSIKAR-----EANL-NMVVDIEYKTRGE R---ISRIQLTQQKPVA---KPIEVT----QNDDVIV-KTAMSTGVSFVKLKTVYYVMTE SNK-SCLFDTTIDIHDSDQNS--------------------------------------- ------------------------------------------------------DDPMLL SQRIVACAKFKPPEN-SLETESALTVMEINLPTGVTPVLEDLDEYQNGLE-SRISNY-EV IGDKVVLQIDSIPSDNFYCVGFRILE-EFETGMTKASEFTVYEYQAPAFKCTKLYQK-QT RK-LLR-LC-------EEDHCQCMAAECCNFKSTIDP----------------------- -AITAD---------------------------QRTADICKESVKYALKVVIDSSEA-GG DF----VTYKATVQSVLKKGE--TDDLKTDSEVEFIKKASC---------------NSTQ FEIGKQYLTMTAESMKIQVN-RAYKYK--------FPLD---------SEAWVDW-WPLE SDCSDANCKQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------YV------------------------------------------ ---------------------------------------KVLEGF-----EFEYL----- ----------------------LNGCDLMSSR-------------------- >NP_034536.3 complement C5 preproprotein [Mus musculus] -----------------MGLWGILCLL------------IFLD---KTWGQEQTYVISAP KILRVGSSENVVIQVHGYTEAFDATLSLK-SYP-DKKVTFS--SGYVNLSPENKFQNAAL LTLQPNQVPREESP--VSHVYLEVVSK-----HFSKSKKIPITYNNGILFIHTDKPVYTP DQSVKIRVYSLGDDLKPA-KRETVLT--FIDP-EGSEVDIVEENDYT-GIISF-PDFKIP SNPKYGVWTIKANYKKDFTTT-GTAYFEIKEYVLPRFSVSIELERTFIGYKN---FKNFE ITVKARYFYNKVVPDAEVYAFFGLREDIKDEEKQM------MHKATQAAKL--------- VDGVAQISFDSETAV--KELSYNSLEDLN--NKYLYIAVTVTESSGGFSEEAEIPGVKYV LSPYTLNLVATPLFVKPGIPFSIKAQVKD-SLEQAVG-GVPVTLMAQTVDVNQETS---D L-----ETKRSIT-----HDTDGVAVFVLNLPSNVTVLKFEIRTDDPELPEE-------- ----NQASKEYEAVAYSSL-SQSYIYIAWTEN--YKPMLVGEY-LNIMVTPKSPY-IDKI THYNYLILSKGKIVQYGTREKL-------------------FSSTYQN----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSP------DEY- VYSPGQTVSLDMVTEA--DSWVALSAVDRAVYKVQG--NAKRAMQRVFQALDEKSD---- --LGCGAG----------------------GGHDNADVFHLAGLTFLTNANADDSHYRDD S--CK--------EILRSKRNLHLLRQKIEEQAAKYKHSVPKKC-CYDGA----RVNF-Y --ETCEERVAR-----------VTIG----PLCIRA-------FNECCTIANKIRKE--- ----------SPHKPVQLGRIHIKTLLPVMKADIRSYFPESWLWEIHRVP---------- ----------KRKQLQVTLPDSLTTWEIQGIGIS---DNGICVAD-TLKAKVFKEVFLEM NIPYSVVRGEQIQLKGTVYNYMTSGTKFCVKMSAVEGICTSGSSA----ASLHTSRPSRC VFQRIE-GSSSHLVTFTLLPLEIG-----LHSINFSL-------------ETSFGK--DI LVKTLRVVPEG-VKRESYAGVILDPKGIRGIVNRRKE----------------------- ---FPYRIPLDLVPKTKVERILSVKGLLVGEFLS----TVLSKEGINILTHLPKGSAEAE LMSIAPVFYVFHYLEAGNHWNIFYPDTLSKRQSLEKKIKQGVVSVMSYRNADYS--YSMW K---GASASTWLTAFALRVLGQVAKY--VKQDE-----NSICNSLLWLVEKCQ-LENGSF KENSQYLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDI----CP--TMKIHTALDKAD SFLL----ENTLPSK-STFTLAIVAYALSLGDRTHPRFRLIVSALRKEAFVK--GD--PP IYRYWRDTLK-------RPDSSVPSSGTAGMVETTAYALLASLKLKD--------MNYAN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLK-----QIHL-DMDINVAYKHEGD ----FHKYKVTEKHFLG---RPVEVS----LNDDLVV-STGYSSGLATVYVKTVVHKISV SEE-FCSFYLKIDTQDIEASS--------------------------------------- ----------------------------------------------------HFRLSDSG FKRIIACASYKPSKE-ESTSGSSHAVMDISLPTGIGANEEDLRALVEGVD-QLLTDY-QI KDGHVILQLNSIPSRDFLCVRFRIFE-LFQVGFLNPATFTVYEYHRPDKQCTMIYSI-SD TR-LQK-VC-------EGAACTCVEADCAQLQAEVDL----------------------- -AISAD---------------------------SRKEKACKPETAYAYKVRITSATE-EN VF----VKYTATLLVTYKTGE---AADE-NSEVTFIKKMSC---------------TNAN LVKGKQYLIMGKEVLQIKHN-FSFKYI--------YPLD---------SSTWIEY-WPT- -DTTCPSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------ENLNNF-----AEDLF----- ----------------------LNSCE------------------------- >NP_444179.1 complement C5 precursor [Rattus norvegicus] MP------------LPAMGLWGLLCLL------------IFLD---KTWGQEQTYVISAP KIFRVGSSENVVIQAHGYTEAFDATISLK-SYP-DKKVTYS--SGYVNLSPENKFQNSAL LTLPPKQFPRDENP--VSHVYLEVVSM-----HFSKSKKIPITYDNGFLFIHTDKPVYTP DQSVKIRVYSLSDDLKPA-KRETVLT--FVDP-EGTEVDIVEENDYT-GIISF-PDFKIP SNPKYGVWTIKAKYKKDFTTT-GTAYFEVKEYVLPRFSVSIEPESNFIGYKN---FKNFE ITVKARYFYNKMVPDAEVYIFFGLREDIKEDEKQM------MHKAMQAATL--------- VNGVAQISFDSETAV--KELSYESLEDLN--NKYLYIAVTVTESSGGFSEEAEIPGIKYV LSPYTLNLVATPLFLKPGIPFSIKVQVKD-SLEQLVG-GVPVTLMAQTVNVNQETS---D L-----EPKRSIT-----HSADGVASFVVNLPSEVTSLKFEVKTDAPELPEE-------- ----NQASKEYEAVTYSSL-SQSYIYIGWTEN--YKPMLVGEY-LNIIVTPKSPY-IDKI THYNYLILSKGKIVQYGTKEKL-------------------LYSSYQN----------IN IPVTQDMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSP------DKD- VYSPGQTVSLDMVTEA--DSWVALSAVDSAVYGVRG--KAKRAMQRVFQAFDDKSD---- --LGCGAG----------------------GGRDNVDVFHLAGLTFLTNANADDSQYHDD S--CK--------EILRPKRDLQLLHQKVEEQAAKYKHRVPKKC-CYDGA----RENK-Y --ETCEQRVAR-----------VTIG----PHCIRA-------FNECCTIADKIRKE--- ----------SHHKGMLLGRIQIKALLPVMKAEIRSYFPESWLWEVHRVP---------- ----------KRNQLQVALPDSLTTWEIQGIGIS---DNGICVAD-TLKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGTMFCVKMSAVEGICTPGSSA----ASPQTSRSSRC VRQRIE-GSSSHLVTFSLLPLEIG-----LHSINFSL-------------ETSFGK--EI LVKTLRVVPEG-IKRESYAGVTLDPRGVYGIVNRRKE----------------------- ---FPYRIPLDLVPKTNVKRILSVKGLLIGEFLS----TVLSKEGIDILTHLPKGSAEAE LMSIVPVFYVFHYLEAGNHWNIFHPDTLARKQSLQKKIKEGLVSVMSYRNADYS--YSMW K---GASSSAWLTAFALRVLGQVNKY--VKQDQ-----YSICNSLLWLIEKCQ-LENGSF KENSQYLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGI----CP--TEKIYTALAKAD SFLL----ERTLPSK-STFTLAIVAYALSLGDRTHPKFRSIVSALKREALVK--GD--PP IYRFWRDTLQ-------RPDSSAPNSGTAGMVETTAYALLTSLNLKE--------TSYVN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLHL-DMDINVSYKHKGD ----FYQYKVTEKNFLG---RPVEVP----LNDDLIV-TTGYSSGLATVYVKTVVHKTSV AEE-FCSFYLKIDTQEVEASS--------------------------------------- ----------------------------------------------------YLSYSDSG HKRIIACASYKPSKE-ESASGSSHAVMDILLPTGIGANQEDLRALVEGVD-QLLTDY-QI KDSHVILQLNSIPSRDFLCVRFRIFE-LFQVGFLNPATFTVYEYHRPDKQCTMIYST-SD TN-LQR-VC-------EGAACKCVEADCGQLQAELDL----------------------- -AISAD---------------------------TRKETACKPEIAYAYKVRITSATE-EN IF----VKYTATLLDIYKTGE---AAAEKDSEITFIKKISC---------------TNAN LVKGKQYLIMGKEALQIKHN-FSFKYI--------YPLD---------SSTWIEY-WPT- -DTTCPSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGCENA----------------------- >NP_001001646.1 complement C5a anaphylatoxin precursor [Sus scrofa] -----------------MGLWGILCFL------------IFLG---KTWGQEQTYVISAP KILHVGAAENIVVQVYGYTEAFAVTVSVK-SYP-DKKITYS--SMYVILSTENKFQNSAF LTIQPKQLLGKPNS--VSHVYLDIVSK-----HFSRSKKIPVTYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDELKPA-KRETVLT--FIDP-QGSEVEVLEENDYT-GIISF-PDFKIP SNPKYGVWTIQAKYREDFSTT-GTAYFEIKEYVLPHFSVSIEPENNFIGYKD---FNDFE ITVKARYFYNKVVSEADVYMFFGIREDLKDEQKVM------MQKAMRNTML--------- INGIAKVTFNSETAI--KELSYDSLEDLN--NKYLYIGVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFVKPGIPYSIKVQVKD-SLDLLVG-GVPVILSAQTLDANQETS---D L-----ESKKSVT-----RSRDGVASFVVNLPAGVTVLEFNIRTEDPDLSDE-------- ----NQARANYRAIAYSSL-SQSYLYIEWTQN--YKPVLVGEH-LNVVVTPKSPY-IDKI THYNYLILSRGKIVHFGTREKL-------------------SNSAYQS----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------NTD- TYSPGQHVSLNLVTEL--DSWVALSAVDKAIYGVQM--TAKKPLERVFQTF-EKND---- --LGCGAG----------------------GGRNNADVFHLAGLTFLTNANTDDIRENDE P--CK--------DILRPKRM---LQKKIEEEAAKYKYAMLKKC-CYDGA----YRND-D --ETCEERAAR-----------IKIG----PKCVKA-------FKDCCYIANQVRAE--- ----------ESHKNIQLGRLHIKTLLAVTNPEIRSYFPESWLWEVHHVP---------- ----------RRNQLQFVLPDSLTTWEIQGIGIS---NSGICVTD-TLNAKVLKDVFLEM SIPYSVVRGEQIQLKGTVYNYGTSGVLFCVKMPPVEGICSSGSPG----IDPQGKKSSRC QPQKIE-GSSSHLVTFDVLPLEIG-----LHNINFSL-------------ETSLGR--EI LVKTLRVVPEG-VKRESYAGITLDPRGIYGAMTRRKE----------------------- ---FPYRVPLDLVPKTKVKRIVSVKGLLIGEVMS----AVLSQEGIDILTHLPKGNAEAE LMSIVPVFYVFHYLEAGNNWNIFSSNSLAQRQNLQKKLREGVVSVMSFRNADHS--YSMW K---SGSASTWLTAFALRVLGQASKY--IDQDL-----NSICNSILWLVEKCQ-LGNGSF KENSEYQPIKLQGTLPIEAQENTLYLTAFAVIGIRKAFDL----CP--LMKISMALTKAD TFLL----ENTRSTR-STFALAIAAYALSLGDKSHPQFRSIVSALKKEALVK--GN--PP IYRFWKDDLQ-------KKDRSVPNTGTARMVETTAYALLTSLNLKD--------MNYVN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIK-----NFLL-NMDVKVSYKHRGD ----FYHYKITEKNFIG---RPVEVP----LNDDLVVFSTGQNSGLATVHVKTVVHKTST SEE-VCSFDLKIEIQDIEASS--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGVNANAEDLRALVEGVD-QLLTDY-EI KDGHVICQLNSIPSNNFLCVRFRIVE-LFQVGFLSPATFTVYEYHRPDKQCTMFYSM-SQ TK-LQK-VC-------EGVTCKCVEADRGQMQTEVDL----------------------- -TISVN---------------------------TRKETACKPEIAYVYKVKIIAMTE-ES AF----VKYTASLLDVYKAGE---AVAEKGSEITFIKKTTC---------------TNAN LEKGKQYLIMGKEALQIKHN-FNFKYI--------YPLD---------SSTWIEY-WPT- -DTACPSCQT-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----TEDIF----- ----------------------LNNCENA----------------------- >XP_415405.5 complement C5 isoform X1 [Gallus gallus] -----------------MAILMYFFVL------------VFSG---TAFSQDKTYVLTAP KVFRVGTSEKVVVQAFGYEKEFAVNLALR-SFP-DKLVAYS--SGHISLNPDNNFQSSVT VTLQPTDLAGPEDS--VKYVYLEAVSP-----HFTGLKKVPVSYENGFLFVHTDKPIYTP DQSVKVRVYSLNEELQPA-RRETVLT--VVDP-DGVKVDIIEENDFT-GIVSF-PDFKIP PNPKYGIWKIEAKYKKNFITS-AVAKFEVKEYAMPSFSIVIEPENNFISSDK---FENFR IAVKASYFYNKRLAKADVFLRFGI---IEGTEKRM------MPRAMLVAKL--------- TNGVAEINFNSKKAV--SSLGFQSLEELD--GSYLYIAASVVESMGGLSGEVEFSEVKYA VSPYTLSLIATPLFIKPGLPFFIKVQVKD-TVDRFVG-NIPLVITAKSFSQQMDET---E LISEGSESGRRET-----SINDGTALFVVNVPTDSNLLEFQVKTADPHLSDE-------- ----NQATKTYEARVYSSL-SQSYLYIDWASN--HKILSVGDF-ISINIYPRSRY-IHNI HHYSYLITSKGKIVSFGTQKRI-------------------KDLEYEH----------LS FQITQEMVPSARLIVYYIV-GEEPAELVADSVWLNVEQKCGSSLDIKLLS------SKE- THKPAEIVSLNMKTQF--DSFVALSSIDKAIYGVTG--RGKRAMEKIMLKL-EKSD---- --LGCGAG----------------------GGQNNVDVFRMAGLTFLTNANADDSNEAGG K--CS--------EVIRTKRS--DFEEQVLKEASKYKHLEIRKC-CMHGV----KAYPVS --ETCSDRARR-----------IQSH----AKCVSA-------FRHCCEFANRLREE--- ----------EPSKLLILARKQFEAFLELDEAEVRSYFPESWLWEVHQVSP--------- ----------RSKTLSITLPDSLTTWEVQGVGIS---DKGICVAA-PLEVQVVKDIFLSI YVPYSVVRGEQIELKGSVYNHRASAIKFCVKIAAGDGICSSGDSA----TTRQ--RMHNC NLKNLG-AGSSSPIVFRILPLELG-----LHTINFTL-------------LTTGSS--ET VVKTLRVMPEG-IKKELHAGFTLDPQGVYGSIKRRQE----------------------- ---FRYKIPLNLVPKTKIDRSVSVKGHLMGEVIA----TILSPEGLSILTNLPKGSAEAE LMTIAPVFYVFHYLEASNNWHILGPETLTSRTAMRRKMKEGIVSVLSFRNSDFS--YSMW K---NGKASTWLTAFALRILGQVNQY--INLDQ-----ISVCNSLLWLIDNCQ-MPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSIIGIEKSIKI----CP--TQKIHDAKNKAG DYLL----TNVQSAQ-SPFTMAIISYALALVDLNHQAARSLFSALKREASVI--GD--PP IYRFWKDDFK-------TSDLLAPSPVTAQMVETTAYALLTALLRGD--------KNYAN PIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVK-----RLHL-DMGIKVAYRNHGD ----LHLFKLTEDNFVG---RSVTVP----LDDDIYV-STGSSTGIATVNVRTVYNVMGT SEE-SCNFELKIVPKRDDGYR--------------------------------------- ------------------------------------------------------GEDGGP LGRLEACAKYRPSRR-EPQSGSAHVVMDISLVSGLEANSEDLSTLASGVD-QLIADY-EI KDGHVILQIDSVPADRFLCVGFRISQ-LFHVGMLNPGTFSVYEYHAPDKRCTVFYNPYGN EK-LVR-LC-------EGDECKCMEAECSKVQERLDQ----------------------- -SITAD---------------------------TRREVACQNDIAYVYKVNILSRSE-EG YF----VKYSATILDLYKRGQ---AFAQKNNEVTFVKKKTC---------------ANVE LSPGMQYLIMGKEALKINIG-YSFRFQ--------YPLD---------SSTWIEW-WPP- -NTACTFCQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------NRMEDF-----VEDLI----- ----------------------ISGC-------------------------- >XP_016817059.1 complement C5 isoform X1 [Pan troglodytes] MPGSLGREA-----SGRAGSTGCGAF---------------------AFGLRCRYVISAP KIFRVGASENIVIQVYGYTEAFDATISIK-SYP-DKKFSYS--SGHVHLSSENKFQNSAI LTIQPKQLPGGQNP--VSYVYLEVVSK-----HFSKSKKMPITYDNGFLFIHTDKPVYTP DQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEEIDHI-GIISF-PDFKIP SNPRYGMWTIKAKYKEDFSTT-GTAYFEVKEYVLPHFSVSIEPEYNFIGYKN---FKNFE ITIKARYFYNKVVTEADVYITFGIREDLKDDQKEM------MQTAMQNTML--------- INGIAQVTFDSETAV--KELSYYSLEDLN--NKYLYIAVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFLKPGIPYPIKVQVKD-SLDQLVG-GVPVTLNAQTIDVNQETS---D L-----DPSKSVT-----RVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE-------- ----NQAREGYRAIAYSSL-SQSYLYIDWTDN--HKALLVGEH-LNIIVTPKSPY-IDKI THYNYLILSKGKIIHFGTREKF-------------------SDASYQS----------IN IPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DAD- AYSPGQTVSLNMATGM--DSWVALAAVDSAVYGVQR--GAKKPLERVFQFL-EKSD---- --LGCGAG----------------------GGLNNANVFHLAGLTFLTNANADDSQENDE P--CK--------EILRPRRM---LQKKIGEIAAKYKHSVVKKC-CYDGA----CVNN-D --ETCEQRAAR-----------ISLG----LRCVKA-------FTECCVVASQLRAN--- ----------ISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVP---------- ----------RRKQLQFALPDSLTTWEIQGVAIS---NNGICVAD-TVKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPV----IDHQGTKSSKC VRQKVE-GSSSHLVTFTVLPLGIG-----LHNINFSL-------------ETSFGK--EI LVKTLRVVPEG-VKRESYSGVTLDPRGIYGTISRRKE----------------------- ---FPYRIPLDLVPKTEIKRILSVKGLLVGEILS----AVLSQEGINILTHLPKGSAEAE LMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYS--YSVW K---GGSASTWLTAFALRVLGQVNKY--VEQNQ-----NSICNSLLWLVENYQ-LDNGSF KENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI----CP--LVKIDTALIKAD NFLL----ENTLPAQ-STFTLAISAYALSLGDKTHPQFRSIVSALKREALVK--GN--PP IYRFWKDNLQ-------HKDSSVPNTGTARMVETTAYALLTSLNLKD--------INYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLRL-SMDIDVSYKHKGA ----LHNYKMTDKNFLG---RPVEVL----LNDDLIV-STGFGSGLATVHVTTVVHKTST SEE-VCSFYLKIDTQDIEASH--------------------------------------- ----------------------------------------------------YRGYGNSD YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVD-QLFTDY-QI KDGHVILQLNSIPSSDFLCVRFRIFE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SN IK-IQK-VC-------EGATCKCVEADCGQMQEELDL----------------------- -TISTE---------------------------TRKQTACKPEIAYAYKVSITSITV-EN VF----VKYKATLLDIYKTGE---AVAEKDSEITFIKKVTC---------------SNAE LVKGRQYLIMGKEALQIKYN-FSFRYI--------YPLD---------SLTWIEY-WPR- -DTTCSSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGC-------------------------- >XP_038512006.1 complement C5 isoform X1 [Canis lupus familiaris] -----------------MGLWGILWFL------------IFLG---KSWGQEQTYVISAP KVFRVGASENVVIQVYGYTEEFDATISIK-SYP-DRKFSYS--SGYVTLSPENKFQNNVV LTIQPKQLSGGQGP--VSHVYLEVVSR-----HFSKSKKVPITYDNGFLFIHTDKPIYTP QQSVKVRVYSLNDDLKPA-KRETVLT--YIDP-EGSEVDIVEENDYT-GIISF-PDFKIP SNPKYGVWTIRAKYKEDFSTT-GTTQFEVKEYVMPHFTISIEPEKSFIGYKD---FNNFE ITIKARYFYNKVVTEAEVYISFGIRDDLKSDQKEM------MQKAMRDTML--------- INGVAQVTFNSETAI--KELSYSSLEDLN--DKYLYIGVTVIESTGGFSEEAEIPGIKYI LSPYKLNLVATPLFLKPGIPYSIKVQVKD-VLDQLVG-EVPVTLSAHSVNVNQEVS---D L-----ESKKSVT-----RSSDGVASFVVNLPSGATVLEFNVKTADPDLPEE-------- ----NQASKDYQAIAYSSL-SQSYLYIDWTEN--YKPFLVGEH-LNIIVTPRSPY-IDNI TNYNYLVLSKGKIVHFGKAEKL-------------------PDSSYQS----------VN IPVTPDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------SAN- SYYPGQSVSLNMVTES--SSWVALSAVDSAIYGVQG--QAKKPMQRVFQAL-ETSD---- --LGCGAG----------------------GGRNNAEVFYLAGLTFLTNANADDTQEDDK P--CK--------EILRPRRM---LRKKIEEEAAKYKQAVLKKC-CYDGA----NRNY-D --ETCEQRAAR-----------IKVG----PWCAKA-------FRACCDIASQHRTD--- -----------SNKPLQLGRLQIKHLLPVTKPEIRSYFPESWLWEVHHVSG--------- ----------RRNQLQFGLPDSLTTWEIQGVGIS---DSGICVAD-TLKVQVFKDIFLEM NIPYSVVRGEQIELKGTVYNYRRFGIRFCVQMSAAEGICTAGGSA----GDRRGPDPSKC RSLRLE-GSSSHLVTFSVLPLEIG-----LHNINFSL-------------ETSLGR--EI LVKTLRVVPEG-IKKESYAGVTLDPRGIYGVISRRKE----------------------- ---FPYRIPLDLVPKTEVKRIVSVKGMLMGEVMS----AVLSQEGIDILTHLPKGNAEAE LMSVVPVFYVFHYLEAGSNWNIFSPNSLMKKQSLKNQLKQGMVSITSYRNADYS--YSMW K---GGDASTWLTAFALRVLGQVQKY--IGQNQ-----NSICNTLLWLTENCQ-LENGSF KENSQYQPVKLQGTLPTEAHEHSLYLTAFAVIGIRKAFDL----CP--LQKINAALTRAD AFLL----EGAPSAR-STFTLAIAAYALSLGDRTHPQFYSIVSGLKRKALVK--GD--PV IYRFWKDDHQ-------EQERSTATAGTARTVETTAYALLTCLSLGD--------VAYVN PVVRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIK-----QLHL-NMDVKISYKHKGD ----LYHYKMTEKNFLG---RPIEVP----LNDDLVV-STGFSNGLATVHVTTVVQKTST SEE-VCSFDLKIDTQDIEASS--------------------------------------- ----------------------------------------------------FRGYSDSD YKRIIACASYKPSKE-ESSSGSSHAVMDISLPTGVSANIEDLRALVEGVD-QLLTDY-QI KDGHVILQLDSIPSDEFLCVRFRIFE-LFQVGFLSPATFTVYEYHRPDKQCTMFYSP-SG SK-LQK-VC-------EGVTCKCVEADCGQMQAELDL----------------------- -TISAD---------------------------ARKETACKPDIAYAYKVHITSITK-EN VF----IKYTATLLDVYKAGE---AAAQKDSEITFIKKATC---------------ANAE LEKGRHYLIMGKEALQIKHN-FSFKYI--------YPLD---------SSTWIEY-WPT- ADAACPACPA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGCENS----------------------- >NP_001160088.1 complement C5a anaphylatoxin precursor [Bos taurus] -----------------MGLWGILCFL------------IFLG---KSWGQEQTYVISAP KVFHVGAYENVVIQAYGYTEEFDATVSIK-SFP-DKKVTYS--SGHVTLSAENKFQNSAT LTIQPKQLSERQSS--VSHVYLEVTSK-----HFSKAKKMPVTYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEENDYT-GIISF-PDFKIP SNPKYGVWTIRAKYKEDFSTT-GTAYFEIKEYVLPHFSISIEPKSNFIGYKD---FTNFE ITIRARYFYNKVVNEADVYITFGIRDNLEDNQKEM------MQKAMQSTAL--------- INGMAQVTFNSETAV--KELSYESLEDLN--NKYLYIGVTIIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFVKPGIPYSVKVQVKD-SFDHLVG-GIPVTLSAKTLDANQEIT---D L-----ESKKSVT-----RSSDGVASFVVNLPSEVTVLEFNIKTEDLDLPEE-------- ----NQASEDYRAVAYSSL-SQSYLYIDWTEN--YKHLLVGAH-LNIVVTPRSPY-IDKI THYNFLILSKGKIVHFGTRDKL-------------------SDSAYQS----------IN IPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSP------ETD- AYSPGQRVSLNMETEL--DSWVALTAVDSAIYGVQR--TAKRPLERVFQTL-EKGD---- --LGCGAG----------------------GGRDNAEVFYLAGLTFLTNANADDTRENDE P--CK--------EILRPKRM---LKKKIEEEAAKYRNAWVKKC-CYDGA----HRND-D --ETCEQRAAR-----------IQAG----PICIKA-------FKSCCAIASQFRAD--- ----------EHHKNMQLGRLHIKSLLPVTKPEIRSYFPESWLWEVHRVP---------- ----------KRNQLQFVLPDSLTTWEIQGVGIS---NSGICVAD-TLKAKVFKSVFLEM NIPYSVVRGEQVQLSGTVYNYRTSGIQFCVKMHPVEGICSSGTPV----TDSQGRRFSKC VLQKIE-GSSNHLVTFTVLPLEVG-----LHNLSFSL-------------ETSVGN--EI LVKTLRVVPEG-VKRESYAGVTLDPQGVYGIISRRKE----------------------- ---FPYRIPLNMVPKTKVKRTVSIKGLLIGEIMS----AVLSQEGIDSLTRLPKGNAEAE LMSVVPVFYVYHYLEAGHNWDIFSTNSLTQKQNLKTKLKEGMVSIMSFRNADYS--YSMW K---GGSASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEKCQ-LENGSF KENSDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKAFDI----CP--LEKISTAVSKAD IFLH----ENALSSQ-SAFTLAIAAYALSLGDKAHPQFRAIVSALKRKAFVK--GN--PP IYRFWKDDLQ-------QRDSFVPNTGTARMVETTAYALLTNLNLKD--------MNYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVR-----KLRL-NMDVKVSYKNKGD ----LYHYKMSDKYFLG---RPIEVP----LNDDLVVLSTGQSSGLATVHVKTVVHKIST SEE-VCSFHLKIETREIEAFG--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKLSSE-ESSSGSSHAVMDISLPTGVNANPEDLKALVEQVD-QLLTDY-EI KDGHVILQLNSIPSNEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SN TK-LQK-VC-------EGVTCKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKETACKPEIAYAYKVEIVAVTE-EN AF----VKYTATLLDIYKAGE---AAAERDAEITFIKKTSC---------------SNAN LEKRKQYLIMGKEALQIKHN-FRFKYV--------YPLD---------SSTWIEY-WPT- -DSRCPSCQR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----TEDIF----- ----------------------LNGCENA----------------------- >XP_024108622.1 complement C5 [Pongo abelii] MRGSLGREA-----SGRAGPTGCGAF---------------------AFGLRCRYVISAP KIFRVGASENIVIQVYGYTEAFDATISIK-SYP-DKKFSYS--SGHVHLSSENKFQNSAI LTIQPKQLPGGQNP--VSYVYLEVVSK-----HFSKSKKMPVTYDNGFLFIHTDKPVYTP DQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEEIDHI-GIISF-PDFKIP SNPRYGMWTIKAKYKEDFSTT-GTTYFEVKEYVLPHFSVSIEPECNFIGYKN---FKNFE ITIKARYFYNKVVTEADVYITFGIREDLKDDQKEM------MQTAMQNTML--------- INGIAQITFDSETAV--KELSYYSLEDVN--NKYLYVAVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFLKPGIPYSIKVQVKD-SLDQLVG-GVPVTLNAQTIDVNQETS---D L-----DPSKSIT-----RVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE-------- ----NQAREDYRAIAYSSL-SQSYLYIDWTDN--HKALLVGEH-LNIIVTPKSPY-IDKI THYNYLILSKGKIIHFGTREKF-------------------SDASYQS----------IN IPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DAD- AYSPGQTVSLNMATGM--DSWVALAAVDSAVYGVQR--RAKKPLERVFQFL-EKSD---- --LGCGAG----------------------GGLNNANVFHLAGLTFLTNANADDSQENDE P--CK--------EILRPRRT---LQKKIEEIAAKYKHSVVKKC-CYDGA----RVNN-D --ETCEQRAAR-----------ISIG----PRCVKA-------FTECCVVASQLRAN--- ----------NSHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVP---------- ----------RRKQLQFALPDSLTTWEIQGVGIS---NSGICVAD-TVKAKVFKDVFVEM NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPA----IDHQGTKSSKC VHRKVE-GSSSHLVTFTVLPLEIG-----LHNISFSL-------------ETSFGK--EI LVKTLRVVPEG-VKRESYSGVTLDPRGIYGTISRRKE----------------------- ---FPYRIPLDLVPKTEIKRILSVKGLLVGEILS----AVLSQEGINILTHLPRGSAEAE LMSIVPVFYVFHYLETGNHWNIFHSDTLIEKQKLKKKLKEGMLSIMSYRNADYS--YSVW K---GGSASTWLTAFALRVLGQVNKY--VEQNQ-----NSICNSLLWLVENYQ-LDNGSF KENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI----CP--LAKIDTALIKAD NFLL----ENTLPAQ-STFTLAISAYALSLGDKTHPQFRSIVSALKREALVK--GN--PP IYRFWKDDLQ-------HKDSSVPNTGTAHMVETTAYALLASLNLKD--------INYVN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLRL-NMDIDVSYKHKGA ----LHNYKMTDKNFLG---RPVEVL----LNDDLIV-STGFGSGLATVHVTTVVHKTST SEE-VCSFYLKIDPQDIEASH--------------------------------------- ----------------------------------------------------YRGYGNSD YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGIGANEEDLKALVEGVD-QLFTDY-QI KDGHVILQLNSIPSRDFLCVRFRIFE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SN IK-IQK-VC-------EGAVCKCVEADCGQMQKELDL----------------------- -AISAE---------------------------TRKQTACKPEIAYAYKVSITSITV-EN VF----VKYKATLLDIYKTGE---AVAEKDSEITFIKKVTC---------------TNAE LVKGRQYLIMGKEALQIKYN-FSFRYI--------YPLD---------SLTWIEY-WPR- -DTTCSSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGC-------------------------- >XP_003207914.2 complement C5 [Meleagris gallopavo] -----------------MAILIYFFVL------------VFSG---TAFGQEKTYVLTAP KVFRVGTTEKVVVQAFGYENEFAVSLALR-SFP-DKIVVYS--SGHISLNPENNFQNSVT VTLQPTDLAGPEDS--VKYVYLEAVSP-----HFTGLKKIPVSYENGFLFIHTDKPIYTP DQSVKVRVYSLNEELQPA-RRETVLT--IVDP-DGVKVDIIQENDFT-GIVSF-PDFKIP PNPKYGIWKIEAKYKKNFITS-AVAKFEVKEYAMPSFSIVIEPEHNFISSDK---FENFR IAVKASYFYNKRLAKADVFLRFGI---IEGTERRM------MPRAMLVTKI--------- TNGVAEINFNSKKAV--SSLEFQSLEELD--GSFLYIAASVAESMGGLSGEVEFSGVKYA VSPYTLSLIATPLFIKPGLPFFIKVQVKD-TVDHFVG-NIPLIITAKSFSQQMDAT---E LISEGSESGRRET-----SINDGTALFVVNIPPDSNLLEFQVKTADPHLSDE-------- ----NQATKTYEARVYSSL-SQSYLYIDWASN--HKVLNVGDF-ISINVYPRSRY-IHNI HHYSYLITSKGKIVSFGTQKRI-------------------KDLEYEH----------LS FQITQEMVPSARLIVYYIV-GEEPAELVADSVWLNVEQKCGSSLDIKLLS------SKE- THKPAEVVSLNMKTQF--DSYVALSSVDKAIYGVTG--RGKGAMKKIMLKL-EKSD---- --LGCGAG----------------------GGQNNVDVFRMAGLTFLTNANADDSNEAGE K--CS--------EVIRTKRS--DFEERVLKEASKYKHLEIRKC-CMHGV----KVYPVS --ETCSDRARR-----------IQSH----PKCISA-------FINCCEFANRLREE--- ----------EPNKLLILARKQFEALLELDETEVRSYFPESWLWEVHQVSP--------- ----------RSKTLSVTLPDSLTTWEVQGVGIS---DRGICVAA-PLEVQVVKDIFLSI YVPYSVVRGEQIELKGSVYNHRASAIKFCVKIAVGDGICSSGGSA----TTGA--RMHNC DFKNLD-AGSSSPIMFRILPLELG-----LHTINFTL-------------LTTGSS--ET VVKTLRVKPEG-IKKELHAGFTLDPQGVYGSIKRRQE----------------------- ---FRYKIPLNLVPKTKIDRSVSVKGHLMGEVIA----TVLSPEGLSILTNLPKGSAEAE LMSVAPVFYVFHYLEASNNWHVLGPETLTSRTQMRRKMKEGIVSILSFRNSDFS--YSMW K---NGQASTWLTAFALRILGQVNQY--VNLDQ-----ISVCNTLLWFIENCQ-MPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSVIGIEKSIKM----CP--TQKIHDAKNKAG DYLL----KNAQSAQ-SPFTMAIISYALALVDLNHQAARSLFSALKREASVI--GD--PP IYRFWKDGFK-------TPDLHAPSSVTAQMVETTAYALLTALLRGD--------KSYAN PIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVK-----RLHL-DMGVKVAYKNHGD ----LHVFKLTEDNFVG---RAVTVP----LDDDIYV-STGSSTGIATINVRTVYNVMGT SEE-SCNFELKIAPKRDNGYR--------------------------------------- ------------------------------------------------------GEDGEP LGHLEACAKYRPSTR-EPQSGSAHAVMDISLVSGLVANTEDLSTLASGVD-QLIADY-EI KDGHVILQIDSVPADRFLCVGFRISQ-LFHVGMLNPGTFTVYEYHAPDKRCAVFYNPYGN EK-LVR-LC-------EGDECKCMEAECSKVQERLDR----------------------- -SITAG---------------------------TRREVACQNDIAYVYKVNILSRSE-EG YF----VKYSATILDLYKRGQ---AFAQKNNEITFVKKKTC---------------TDVE LSPGMQYLIMGKEALKINIG-YSFRFQ--------YPLD---------SSTWIEW-WPS- -NPACTFCQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------NRMEDF-----VEDLI----- ----------------------ISGC-------------------------- >XP_024785786.2 complement C5 isoform X1 [Pan paniscus] MPGSLGREA-----SGRAGSTGCGAF---------------------AFGLRCRYVISAP KIFRVGASENIVIQVYGYTEAFDATISIK-SYP-DKKFSYS--SGHVHLSSENKFQNSAI LTIQPKQLPGGQNP--VSYVYLEVVSK-----HFSKSKKMPITYDNGFLFIHTDKPVYTP DQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEEIDHI-GIISF-PDFKIP SNPRYGMWTIKAKYKEDFSTT-GTAYFEVKEYVLPHFSVSIEPEYNFIGYKN---FKNFE ITIKARYFYNKVVTEADVYITFGIREDLKDDQKEM------MQTAMQNTML--------- INGIAQVTFDSETAV--KELSYYSLEDLN--NKYLYIAVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFLKPGIPYPIKVQVKD-SLDQLVG-GVPVTLNAQTIDVNQETS---D L-----DPSKSVT-----RVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE-------- ----NQAREGYRAIAYSSL-SQSYLYIDWTDN--HKALLVGEH-LNIIVTPKSPY-IDKI THYNYLILSKGKIIHFGTREKF-------------------SDASYQS----------IN IPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DAD- AYSPGQTVSLNMATGM--DSWVALAAVDSAVYGVQR--GAKKPLERVFQFL-EKSD---- --LGCGAG----------------------GGLNNANVFHLAGLTFLTNANADDSQENDE P--CK--------EILRPRRM---LQKKIGEIAAKYKHSVVKKC-CYDGA----CVNN-D --ETCEQRAAR-----------ISLG----LRCVKA-------FTECCVVASQLRAN--- ----------ISHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVP---------- ----------RRKQLQFALPDSLTTWEIQGVAIS---NNGICVAD-TVKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPV----IDHQGTKSSKC VRQKVE-GSSTHLVTFTVLPLGIG-----LHNINFSL-------------ETSFGK--EI LVKTLRVVPEG-VKRESYSGVTLDPRGIYGTISRRKE----------------------- ---FPYRIPLDLVPKTEIKRILSVKGLLVGEILS----AVLSQEGINILTHLPKGSAEAE LMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLSIMSYRNADYS--YSVW K---GGSASTWLTAFALRVLGQVNKY--VEQNQ-----NSICNSLLWLVENYQ-LDNGSF KENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI----CP--LVKIDTALIKAD NFLL----ENTLPAQ-STFTLAISAYALSLGDKTHPQFRSIVSALKREALVK--GN--PP IYRFWKDNLQ-------HKDSSVPNTGTARMVETTAYALLTSLNLKD--------INYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLRL-SMDIDVSYKHKGA ----LHNYKMTDKNFLG---RPVEVL----LNDDLIV-STGFGSGLATVHVTTVVHKTST SEE-VCSFYLKIDTQDIEASH--------------------------------------- ----------------------------------------------------YRGYGNSD YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVD-QLFTDY-QI KDGHVILQLNSIPSSDFLCVRFRIFE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SN IK-IQK-VC-------EGATCKCVEADCGQMQEELDL----------------------- -TISTE---------------------------TRKQTACKPEIAYAYKVSITSITV-EN VF----VKYKATLLDIYKTGE---AVAEKDSEITFIKKVTC---------------SNAE LVKGRQYLIMGKEALQIKYN-FSFRYI--------YPLD---------SLTWIEY-WPR- -DTTCSSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGC-------------------------- >XP_023098426.1 complement C5 [Felis catus] -----------------MGLWGILVFL------------IFLG---KSWGQEQTYVISAP KIFRVGASENIVIQVYGYTEAFDATISLK-SYP-DKKFSYS--SGYVTLSMENKFQNSAV LTVQPKQLSGGQNP--VSHVYLEVVSK-----HFSRSKKVPITYDNGFLFIHTDKPVYTP QQSVKVRVYSLNDDLKPA-KRETVLT--YIDP-EGSEVDIMEENDYT-GIISF-PDFKIP SNPKYGVWTIRAKYKEDFSTT-ATAYFEIKEYVLPHFSVSIEPENSFIGYKD---FNDFE ITIKARYFYNKVVTEAEVYITFGIRDDLKDDQKEM------MQKALQNTML--------- INGIAQVTFNSEMAT--KELSYESLEDLN--DKYLYIGVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFMKPGIPYSIKVQVKN-SFDQLVG-GVPVTLSAQTVDVNQEMS---N L-----ESKKSVT-----HSSDGVASFMVNLPSGARMLEFNVKTDDPDLPEE-------- ----NQAGKVYQAIAYSSL-SQSYLYIDWTGN--YKPLLVGEY-LNVIVTPRSPY-INKI THYNYLILSKGKIVHFGTREKL-------------------PDSSYQN----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------SADA SYSPSQHVSLNMATES--NSWVALSAVDSAIYGVQR--RAKKPLERVFQVL-ETSD---- --LGCGAG----------------------GGRNNADVFHLAGLLFLTNANVDDTREDDK P--CK--------EILRPKRM---LQKKIQEEVAKYKHTVLKKC-CYDGA----YRNE-D --EDCEQRAAR-----------ITIG----PRCVRI-------FKECCLIAKKHRDE--- ----------DPLKNIQLGRLHIKTLLPVSKPEIRSYFPESWLWEVHHVP---------- ----------RRSQLQFVLPDSLTTWEIQGVGIS---NSGICVAD-TLKAQVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRMSGMRFCVKMSTVEGICTSGSQA----IGHQGINPSKC LSQRVE-GSSSHLVTFSVLPLEIG-----LHNINFSL-------------ETSLGK--EI LVKTLRVVPEG-IKKESYAGVTLDPRGIYGVVSRRKE----------------------- ---FPYRIPLDLVPKTKVKRIVSVKGLLIGEVMS----TVLSQEGIDILTHLPKGNAEAE LMSIVPVFYVFHYLEAGKNWNIFSTNSLIQNQNLRKKLKEGMVSIMSYRNADSS--YSMW K---GGSASTWLTAFALRVLGQLNKY--IEQNQ-----NSICNTLLWLVENCQ-LENGSF KENSDYQPIKLQGTLPVEARENTLYLTAFAVIGIRKAFDI----CS--LMKINTAITKAD TFLL----ENTLSAQ-STFTLAIAAYALSLGDKTHPQFRSIVSALKKKALVK--GD--PV IYRFWKDDLQ-------QESTSTPSPSTAHVVETTAYALLTSLSLKD--------INYVN PIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLIK-----QLHL-NMDINVSYKHKGD ----LHRYKMTETNFLG---RPIEVP----LNDDLVV-STGYSNGVATVHVTTVVQKTST SDE-ICSFHLKIEAQDIEASS--------------------------------------- ----------------------------------------------------YRRYSDSD YKRIVACASYKPSKE-ESSSGSSHAVMDISLPTGIGANQEDLKALVERVD-QLLADY-QI KDGHIILQLNSIPSDEFLCVRFRIFE-LFQVGFLNPATFTVYEYHRPDKQCTMFYNP-FD AR-LQK-VC-------EGVTCKCIEADCGQMQTELDL----------------------- -TISAD---------------------------TRKETACKPDIAYAYKVRITSITK-EN VF----VKYTATLLDIYKAGE---AVAQKDSDVTFIKKVTC---------------ANAD LEKGRQYLIMGKEALQIKYN-FSFKYL--------YPLD---------SSTWIEY-WPT- -NAMCPSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGCENP----------------------- >XP_030870703.1 complement C5 isoform X1 [Gorilla gorilla gorilla] -----------------MGLLGILCFL------------IFLG---KTWGQEQTYVISAP KIFRVGASENIVIQVYGYTEAFDATISIK-SYP-DKKFSYS--SGHVHLSSENKFQNSAI LTIQPKQLPGGQNP--VSYVYLEVVSK-----HFSKSKKMPITYDNGFLFIHTDKPVYTP DQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEEIDHI-GIISF-PDFKIP SNPRYGMWTIKAKYKEDFSTT-GTAYFEVKEYVLPHFSVSIEPEYNFIGYKN---FKNFE ITIKARYFYNKVVTEADVYITFGIREDLKDDQKEM------MQTAMQNTML--------- INGIAQVTFDSETAV--KELSYYSLEDLN--NKYLYIAVTVIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFLKPGIPYPIKVQVKD-SLDQLAG-GVPVTLNAQTIDVNQETS---D L-----DPSKSVT-----RVDDGVASFVLNLPSGVTVLEFNVKTDAPDLPEE-------- ----NQAREGYRAIAYSSL-SQSYLYIDWTDN--HKALLVGEH-LNIIVTPKSPY-IDKI THYNYLILSKGKIIHFGTREKF-------------------SDASYQS----------IN IPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DAD- AYSPGQTVSLNMATGM--DSWVALAAVDSAVYGVQR--GAKKPLERVFQFL-EKSD---- --LGCGAG----------------------GGLNNANVFHLAGLTFLTNANADDSQENDE P--CK--------EILRPRRT---LQKAIEEIAAKYKHSVVKKC-CYDGA----CVNN-D --ETCEQRAAR-----------ISIG----PRCVKA-------FTECCVVASQLRAN--- ----------NSHKDMQLGRLHMKTLLPVSKPEIRSYFPESWLWEVHLVP---------- ----------RRKQLQFALPDSLTTWEIQGVGIS---NSGICVAD-TVKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVEGICTSESPV----IDHQGTKSSKC VRQKVE-GSSSHLVTFTVLPLEIG-----LHNINFSL-------------ETSFGK--EI LVKTLRVVPEG-VKRESYSGVTLDPRGIYGTISRRKE----------------------- ---FPYRIPLDLVPKTEIKRILSVKGLLVGEILS----AVLSQEGINILTHLPKGSAEAE LMSVVPVFYVFHYLETGNHWNIFHSDPLIEKQKLKKKLKEGMLNIMSYRNADYS--YSVW K---GGSASTWLTAFALRVLGQVNKY--VEQNQ-----NSICNSLLWLVENYQ-LDNGSF KENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI----CP--LVKIDTALIKAD NFLL----ENTLPAQ-STFTLAISAYALSLGDKTHPQFRSIVSALKREALVK--GN--PP IYRFWKDNLQ-------HKDSSVPNTGTARMVETTAYALLTSLNLKD--------INYVN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLRL-NMDIDVSYKHKGA ----LHNYKMTHKNFLG---RPVEVL----LNDDLIV-STGFGSGLATVHVTTVVHKTST SEE-VCSFYLKIDTQDIEASH--------------------------------------- ----------------------------------------------------YRGYGNSD YKRIVACASYKPSRE-ESSSGSSHAVMDISLPTGISANEEDLKALVEGVD-QLFTDY-QI KDGHVILQLNSIPSSDFLCVRFRIFE-LFEVGFLSPATFTVYEYHRPDKQCTMFYSA-SN IK-IQK-VC-------EGATCKCVEADCGQMQEELDL----------------------- -TISTE---------------------------TRKQTACKPEIAYAYKVSITSITV-EN VF----VKYKATLLDIYKTGE---AVPEKDSEITFIKKVTC---------------TNAE LVKGRQYLIMGKEALQIKYN-FSFRYI--------YPLD---------SLTWIEY-WPR- -DTTCSSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGCQNS----------------------- >XP_011478017.1 complement C5 [Oryzias latipes] M----------------KVCVLLLCVC------------CLCW---RTQAQPKSYLVTAP SSFRVDAVETVFVQLFGYTREVTVFVFLKDSMA-PNHKLLS--RDVLTLNANNKFQALAN VQLYPNVLTKD-----IQKVVLHVQSD-----EINNHVFVPISRSNGFMFIQTDKPLYTP HQNVKVRAFSMNQELRPA-NRSVFLT--FKDP-DRVTVDVVEMVDINNGIPTMQKRFKIP IKPKLGIWTIEASYSDDFTTT-AVTDFEVKEYVLPSIDINVQPSLNFISDTN---FNSFD FKISARYVHGAPVADGEVFLRYGYV--SGKNAPFI------IPNLVKRERL--------S SSGEVEVNLNMQEVL-SKHDGPRELSSLV--GKYLYMAVLVQEETGGISQEAEFASVKFL KSPYHLSLISTPPFIKPGLPYNIKLLVKD-HLDKPVN-RVSVELVEQRQITETGET---N VLNCGNNNQLR-------SDSDGFIYLICNPWKTSVKAVLKFQTA--GLAEA-------- ----NRATLTLESVAYHSP-NERYLYINTPMF--GKSLVVGRD-TQIQVQTASPS-YLNI QALNYLVLSKGKVVFHKSVDFVR------------------SLDGTNS----------LN FMVTPSMVPSIRLLVFYILHGEGTSELVADSVWIDVKHKCINGLETSVTV------DTR- IHKPKENLNIDIRANQ--PGLVALSAVDSAVYSIRR--NYKDPISMVLRHI-EQSD---- --LGCGGG----------------------GGKDNADVFRLAGLTFLTNANAQSTS-VDE P--CT--------AAVRSKRAL--SDEAKEAKAQSY--GSLKPC-CVKGM----QYIPRS --VTCRQYALQY----------KKLT----HRCREA-------FRECCEFYQKNKDD--- -------------GDLILAR-HIGVNFDEVP-QVRSYFPESWLWEVQPISS--------- ----------GKLSVSGKLPDSLTTWEIQAVGMF--PSGGMCVAD-TAKVSVNLPLSVDI PLPYQVVRGEQVVLQGSVYNQQDKSIKYCVTLMAGPAVCLLQSQP---VSGQPGLHSTGC KWNYLS-ANGVGKVVFTLLGLEPG-----MHTLTFTL-------------KTTDGI-RDI LEKNLRVVPEG-VRRDVDSGGSLDPQGVYGSKKLKVV----------------------- ---LHNQMPANVVPNSAVQRMLAINGELPGEVVT----VLTKPEGIKTLIDLPLGLAIAK LDTLFLLTQVYLYLETTSSWDLFGANSQKSSADLKQKIQDGLIDLSSIRNGDSS--YSTS I---KAEPSTWVTAMVVKVLALADSV--MSLDH-----QSLSESVTWLISKTQ-QADGSF SELSSFKPNRAMVEG-ADPIEKSVYVTSIVLIALQRASEIRDERLQ--LRFHVSSRRSAA GYLS----QHARDVK-SVYVRAVATYALTLHDPNSIAVSELISSLESVARQK--GN--PV ELRYWQEADV-------TADWIKPDQSSGQTVETTSYVLLTMLLKGR--------IPYAN PILSWLTQDQYYGDGFFSSTDMVLTLEALTEYKKLIP-----RTEL-DQQINIRYNRKGE ----VKRVALNRRQPVV---APIEIS----LTDDITV-STGYGKGVSNVKLKTVFYQTTA SLQTRCNFELNIEMSGSNPSE--------------------------------------- -------------------------------------------------------SSSTE APHLAACVKYKPPLN-EVSTASSLTVLKIQLPTGVEPYLEDLRQFMDPDN-PIISHY-EL QGSTVVILMDTVPSDIFLCVGFRVRT-RFKVVGASDCLFTVSERQDRGSLCTKEFSP-QH QM-LQR-LC-------LGEQCQCMTAACAAYRGNVDL----------------------- -SLTSV---------------------------QRREELCQPHVKYGLIVAVRSSAS-EG DF----MIYSASVVEVLKNTEKDLEALNPKSEVELVKKATC---------------TSIN LQDNKQYLVFGSRGSEVQNG-RHFKYR--------LALD---------SEALVEL-LST- -DCSSDLCQK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------HQ------------------------------------------ ---------------------------------------AQMEDF-----SVYFM----- ----------------------LNECI------------------------- >XP_005512961.1 complement C5 isoform X1 [Columba livia] -----------------MTILMCFFVF------------LFSG---TTFGQEKTYVLTAP KIFRAGASEKVVVQAFGFEKEFPVNIAIK-SLP-DKITVYS--SDRISLTPANKFQDAAT LTLQPADLPRTENS--VNYVYLEAVSP-----HFTRLKKIPVSYENGFLFIHTDKPIYTP DQSVKVRVYSLNEELQPA-RRETVLT--FVDP-EGVKVDIVEEEDFT-GIVSF-PDFKIP PNPKYGIWKIEAKYKKNFITS-AVAKFEVKEYAMPSFSITIEPESNFISSDK---FESFR IVVKASYFYNKRLPSADVFLRFGI---IEESEKRM------MPRAMHVTRI--------- ENGVAAINFNSKQAV--SFIGFQSLEELD--GSYLYIVASVLESEGGLSGEAEFAGVRFA VSPYKLSLIATPLFVKPGLPFFIKVQVKD-TGDHFVG-NVPITISAKSVGEQTDET---E LISEHSESRRRKT-----STNDGTALFVVNIPSDCKILEFQVKTADPHLSDE-------- ----NQASKTYEAKAYSSL-SQSYLYIDWASN--HKILEVGDF-VNIKVYPHSRY-IHKI HHYSYLITSKGKIVSFGTQKRM-------------------KDLEYEH----------LT FQITQEMVPSARLIVYYIVMGEEAAELVADSIWLNVEQKCGNSLDIRLQS------SKE- ILKPAEAISLDMKTEF--SSFVALSSIDKAVYGVTA--SGKRAMEKIMLHL-EKSD---- --LGCGAG----------------------GGRNNIDVFRMAGLTFLTNANADDSNEAGE T--CN--------EVLRTKRS--DFKEKILKEASKYTHPEVRKC-CMAGV----KAYPVS --ETCSDRARR-----------IRRN----EKCISA-------FTDCCEFANRLREE--- ----------EPNKLLILARMHFESVLELDEAEVRSYFPESWLWEVHQVSP--------- ----------RSKTLSVTLPDSLTTWEVQGVGIS---DKGICVAA-PLEVPVVKDIFLSV YVPYSVVRGEQIELKGSVYNHRDSPIKFCVKIAAGNGICAF-DSA----TAGS--RMHSC NLKNLD-GGSSAPVTFRILPLELG-----LHTINFTL-------------LTARNS--EI VVKTLRVMPEG-VKKELHAGFTLDPQGVYGSIKRRQE----------------------- ---FRYKIPLNLVPKTKIDRSVSVKGHLMGEAIA----TVLSPSGLGVLTALPKGSAEAE LVSIAPVFYVFHYLEESNNWHLLGPETLTSRTRLRRKMKEGIVSILSFRNSDFS--YSMW K---NGQASTWLTAFALRILGQVNQY--INLDQ-----ISVCNSLLWLIENCQ-MPDGSF SEFSDYQPVKLQGTLPREAKEKSLYLTAFSLIGIEKSIQI----CP--TQKIHDAKNKAG DYLM----KNVRSAQ-SPFTMAITSYALALMDLNHLSARAAFSALKKEASVI--GD--PP IYRFWKNTFK-------TPDQHTPSPVTAQMVETTAYALLTTLLRGD--------ANYAK PIIKWLSEEQRYGGGFYSTQDTINALEALTEYSLLVK-----RLSL-DMSVKVAYKNHGN ----LHLFKLTEDNFVG---RTLTVP----LGDDIYV-STGSSTGIATVNVKTVYNTIGT SEE-SCNFELKIVPKRADGYR--------------------------------------- ------------------------------------------------------KEDGEP LGRLEACAKYRPGVR-EPQSGSAHAVMDIGLVSGLEANTEDLSTLASGVD-QLIADY-EI KDGHVILQIDSVPANNFLCVEFRISE-LFQVGMLNPATFTVYEYHAPDKRCTMFYNPYGN EK-LVR-LC-------EGDECKCMEAECSKVQERLDR----------------------- -SLTAD---------------------------TRREAACQSDIAYVYKVNILSRSE-EG YF----VKYSATLLDLYKRGQ---AFAQKNNEVTFVKKKTC---------------TDVE LSPGEQYLIMGKEALKISVG-YNFKFQ--------YPLD---------SSTWIEW-WPS- -NTACAYCQE-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------NTMEDF-----TEDLM----- ----------------------ISGC-------------------------- >XP_013821764.2 PREDICTED: complement C5 [Capra hircus] -----------------MGLRGILCFL------------IFLG---KSWGQEQTYVISAP KVFHVGASENVVIQVYGYTEEFDATVSIR-SFP-DKKVTYS--SVHVTLSAENKFQNSAT LTIQPKQLSERQSS--VSHVYLEVISK-----HFSQAKKMPITYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMIEENDYT-GIISF-PDFKIP SNPKYGVWTIRAKYKEDFSTT-GTAYFEVKEYVLPHFSISIEPESNFIGYKD---FTNFE ITIRARYFYNKVVNEADVYISFGIRDNLEDNQKEM------MQKAMQSRTL--------- INGIAQVTFNSETAV--KELSYESLEDLN--DKYLYIGVTITESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFVKPGIPYSIKVQVKD-SFDHLVG-GIPVTLSAKTFDVNQEIS---D L-----ESKKSVT-----RSSDGVASFVVNLPSEVTVLEFNIKTEDLDLPEE-------- ----NQASEDYRAVAYSSL-SQSYLYIDWTEN--YKHLLVGEH-LSIVVTPRSPY-IDKI THYNYLILSKGKIVHYGTRDKL-------------------SDSAYQS----------IN IPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSP------RTD- TYSPGQRVSLTMETEL--DSWVALTAVDSAIYGVQR--TAKRPLQRVFQTL-ETSD---- --LGCGAG----------------------GGRDNADVFYLAGLTFLTNANADHTREDDE P--CK--------EILRPKRM---LKKKIEEEAAKYRHINVKRC-CYDGA----HRND-D --ENCEQRAAR-----------IKKG----PICIKA-------FKECCAIASEFRAN--- ----------KTYKNIQLGRLHVKSLLPVTKPEIRSYFPESWLWEVHHVP---------- ----------KRNQLQFVLPDSLTTWEVQGVGIS---NSGICVAN-TLKAKVFKSVFLEM NIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPG----TDSQGRRFSKC VPQKIE-GSSNHLVTFTVLPLEIG-----LHNLSFSL-------------ETSVGN--EI LVKTLRVVPEG-VKRESYAGVTLDPQGIYGIISRRKE----------------------- ---FPYRIPLNMVPKTKVKRTVSIKGLLIGEVMS----AVLSEEGIDSLTHLPKGNAEAE LMSAVPVFYVYHYLEAGHNWDIFSTNSLTQKQNLKTKLKEGMASIMSFRNADYS--YSMW K---GGGASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEKCQ-LENGSF KENSDYQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDI----CP--LEKISTAVSKAD IFLH----ENALSTQ-SAFTLAIAAYALSLGDKSHPQFRSIVSALKKKAFVK--GN--PP IYRFWKDDLE-------QKDSSAPNTGTARMVETTAYALLTSLSLKD--------MNYVS PIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLGR-----KLRL-NMDVKVSYKNKGD ----LYHYKMSEKYFLG---RPIEVP----LSDDLVVLSTGQSSGLATVHVKTVVHKIST SEE-VCSFHLKIETREIEAFG--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKFSSE-ESSSGSSHAVMDISLPTGVNANPEDLKALVEQVD-QLLTDY-EI KDGHVILQLNSIPSNEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SH TK-LQK-VC-------EGATCKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKERACKPDIAYAYKVEIIAVTE-EN AF----VKYTATLLDVYKAGE---AAAERDAEITFIKKTTC---------------SNAN LEKRKQYLIMGKEALQIKYN-FRIKYV--------YPLD---------SSTWIEH-WPT- -DSRCPSCQR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDAF-----TEDIF----- ----------------------LNGCENA----------------------- >XP_014382164.1 complement C5 [Alligator sinensis] MRFHQYLLASLGWCLSAMNIFSFFCIL------------VVCG---RSVSQEQTYVVSAP KILRVGASEKVVIQAFGYKNEFSVNIAIK-SYP-DKQTVYS--SGRVSLSSANKFQGSVT LMIQPKDLPGPGSS--V-HVYLEASSV-----HFTREKKMLVTYDNGYLFIQTDKPIYTP DQSVKVRVYSLNQELKPA-QRETVLT--FVDP-EGVKVDIIEENDFT-GIVSF-PDFKIP SNPKYGTWKIEAKYKKSFTTT-AFTKFEVKEYAMPSFSVSIEPEYNFISFEK---FEKFK ITIQASYFYNKVVAWADVFVRFGI---IEANEKTM------MPKAMHVAEM--------- TNGVAEINFNSRNAV--RDIGRQSLEELN--GAYLYIAATVLESDGGHSEEAEFFGVKFV LSPYKLNLVATPLFVKPGLPFSIKVQVKD-TLSQPVG-NLPVTLTANVVNEQMDST---H LVREGSESGRRQT-----SRTDGTALFIVNIPSDSKTLEFQVKTADPSLSEE-------- ----NQATERYEATAYSSL-SKSYLYIDWASN--HKMLHVGDH-ININVHPSSHY-IHKI YYYSYLILSKGKIISFGTQARI-------------------NDTDYEH----------VS FQLTQDMVPSARLLVYYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSS------RQE- SYKPGKNIPFYMKTQF--SSFVTLSSMDKAIYGVAG--TRKRSMERVMLEL-EKSD---- --LGCGAG----------------------GGQNNVNVFRLAGLTFLTNANADDSKDADE M--CA--------AIVRSKRF--DFEEEIKKRASRYVLEAVRQC-CMDGV----RAYPVS --ETCEERTKR-----------VQGG----PKCLYA-------FKDCCEYANQLRQQ--- ----------EPNKVLMLARKQFEAFLDLVKPEVRSYFPESWLWEVHQVPQ--------- ----------GSKSLPVTLPDSLTTWEIQGVSIS---DKGICVAD-PLEVQVFKDVFLSM HIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVAAGEGICLFGESS----TGPQ--RMRNC KFSNIE-SSSVSSVTIRLLPLELG-----LHTINFTL-------------YTGRDS--EI LVKTLRVVPEG-IKRELNAGFTLDPKGVYGSVRTRQE----------------------- ---FRHRVPFNMVPKTKMDRTVSVKGQLMGEVIS----AVLKPEGVGFLTNLPKGSAEAE LMSIVPVFYVYHYLEKTSNWDLLGTEILTSEVKMKRKMKEGIVSILSFRNRDFS--YSMW K---DGKPSTWLTAFALRIFGQVSEY--IDLDH-----ISVCNSLVWLTDCCQ-MSDGSF KELSSYQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHM----CP--VQKLQDAKLKAE EYLL----RNVQASQ-STFTLAITCYALALMDLNHPGTRLAFGNLKKEAFAK--GE--PP IYRFWKDTLK-------SLDAFTPNAGTAQMVETTAYALLTTLKGGD--------KMYAN PIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILAA-----RLSL-DMNVKVAYKNHGD ----LHLYKLTEQNFIG---RPVTVP----LDEDIYV-STTGNTGLATVNVRTVYHTIST SDE-ICNFELTVTPKTKQDER--------------------------------------- ------------------------------------------------------RQEGEK PERLEACAKYKPGVR-EPQSESAHAVMDISLPSGVEADEEDLYILATGVD-QLIRSY-EI KDGHIIIQIDSVPANKFLCVAFRINE-IFHVGMLSPATFTVYEYHAPDKKCTIFYNPYGD DR-LVR-LC-------EGNECKCMEAECSQMRKKLDL----------------------- -SVSAD---------------------------TRNEVACQQDIAYVYKVKILSYKE-EG SF----IKYTATLLDVYKRGG---ALVKKNDETTFVKKNTC---------------SDVV LNPGEQYLIMGKEALRIVVG-FSFKYQ--------YPLD---------SKTWIEW-WPS- -NTACPSCKQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------ATMEGF-----VEDLL----- ----------------------ISGC-------------------------- >XP_014459225.1 PREDICTED: complement C5 isoform X1 [Alligator mississippiensis] MWFHQYLLASLGWCLSAMNIFSFFCIL------------VVCG---RSFSQEKTYVVSAP KILHVGASEKVVIQAFGYKNEFSVNIAIK-SYP-DKQTVYS--SGRVSLSSANKFQGSVT LMIQPKDLPGPGSS--V-HVYLEASSV-----HFAREKKMPVTYDNGYLFIQTDKPIYTP DQSVKVRVYSLNQELKPA-QRETVLT--FVDP-EGVKVDIIEENDFT-GIVSF-PDFKIP SNPKYGTWKIEAKYKKSFTTT-AFTKFEVKEYAMPSFSVSIEPEYNFISFEK---FEKFK ITIQASYFYNKVVAWADVFVRFGI---IEANEKTM------MPKAMHVAEM--------- TNGVAEINFNSRNAV--RDIGRQSLEELN--GAYLYIAATVLESDGGHSEEAEFFGVKFV LSPYKLNLVATPLFVKPGLPFSIKVQVKD-TLSQPVG-NLPVTLTANVVNEQMDST---H LVQEGSESGRRQT-----SRTDGTALFIVNIPSDSKTLEFQVKTADPSLSEE-------- ----NQATERYEATAYSSL-SKSYLYIDWASN--HKMLHVGDH-ININVHPSSHY-IHKI YYYSYLILSKGKIISFGTQARI-------------------NDTDYEH----------VS FQLTQDMVPSARLLVYYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSS------RQE- SYKPGKNIPFYMKTQF--SSFVTLSSMDKAIYGVAG--TRKRSMERVMLEL-EKSD---- --LGCGAG----------------------GGQNNVNVFRLAGLTFLTNANADDSKEADE I--CA--------AIVRSKRF--DFKEEIKKRASRYVLEAVRQC-CMDGV----RAYPVS --ETCAERTKR-----------VQGG----PKCLYA-------FQDCCEYANQLRQQ--- ----------EPNKVLMLARKQFEAFLDLVKPEVRSYFPESWLWEVHQVPQ--------- ----------GSKSLPVTLPDSLTTWEIQGVSIS---DKGICVAD-PLEVQVFKDVFLSM HIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVAAGEGICLFGESS----TGLQ--RMRNC KFSNIE-SSSVSSVTIRLLPLELG-----LHTINFTL-------------YTGRDS--EI LVKTLRVVPEG-IKKELNAGFTLDPKGVYGSVRTRQE----------------------- ---FRHRVPFNMVPKTKMDRTVSVKGQLMGEVIS----AVLKPEGVGFLTNLPKGSAEAE LMSIVPVFYVYRYLEETSNWDLLGTEILTSEVKMKRKMKEGIVSILSFRNPDFS--YSMW K---DGKPSTWLTAFALRIFGQVSEY--IDLDH-----ISVCNSLVWLTDRCQ-MSDGSF KELSSYQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHM----CP--VQKLQDAKLKAE EYLL----KNVQAAQ-STFTLAITCYALALMDLNHPGTRLAFGNLKKEAFAK--GE--QP IYRFWKDTLK-------SVDAFTPNAGTAQMVETTAYALLTTLKGGD--------KMYAN PIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILAA-----RLSL-DMNVKVAYKNHGD ----LHLYKLTEQNFIG---RPVTVP----LDEDIYV-STTGNTGLATVNVRTVYHTIST SDE-ICNFELTVTPKTEQDER--------------------------------------- ------------------------------------------------------RQEGEK PERLEACAKYKPGAR-EPQSESAHAVMDISLPSGVEADEEDLYILATGVD-QLIRSY-EI KDGHIIIQIDSVPANKFLCVAFRINE-IFHVGMLSPATFTVYEYHAPDKKCTIFYNPYGD DR-LVK-LC-------EGNECKCMEAECSQMRKKLDL----------------------- -SVSAD---------------------------TRNEVACQQDIAYVYKVKILSYKE-EG SF----IKYTATLLDVYKRGG---TLVKKNDEITFVKKNTC---------------SDVV LNPGEQYLIMGKEALRIVVG-FSFKYQ--------YPLD---------SKTWIEW-WPS- -NTACPSCKQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------ETMEGF-----VEDLL----- ----------------------ISGC-------------------------- >XP_008271599.1 PREDICTED: complement C5 isoform X1 [Oryctolagus cuniculus] -----------------MGLWGIFCFL------------IFMG---KSWGQEQTYVISAP KVLRVGASENIVIQVYGYTEAFDSTISIK-SYP-DKKFSYS--SGYVSLSSENKFQNSAT LTIQPKQLSTGQNA--PSHVYLEVVSK-----HFSRSKKMPITYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLV--FIDP-EGSEVDMVEENDYT-GIISF-PDFKIP SNPKYGVWTIKAKYKEDFSTT-GTTYFEVKEYVLPHFSVSIEPESNFIGYKN---FKNFE ITIKARYFYNKVVSDAEVFIFFGIREDLKDDQKEM------MHKAMKSTTL--------- INGVAQVTFDSEVAT--KELSYYSLEDLN--NKYLYIAVTVIESTGGFSEEAEVPGIKYV LSPYKLNLVATPLFLKPGIPYSIKVQVKD-SLDQFVG-GVPVMLNAQTVDVNQQTS---D L-----ETKGSVT-----RLSDGVASFVVNLPSGVTALDFYVKTNAPDLPED-------- ----NQASRKYHAVAYSSL-SQSYLYIDWTEN--YKALLVGEH-LNLIVTPKSPY-IDKI THYNYLVLSKGKIVHFGTREKL-------------------SDSSYQS----------MN IPVTQSMVPSARLLVYYIVSGEQTAELVSDSVWLNIEEKCGNQLQVHLSP------DED- VYSPGQSVSLSMETES--HSWVALTAVDSAVYGVQK--TAKKPMERVFQAL-EKND---- --LGCGAG----------------------GGRNNAEVFNLAGLTFLTNANADSSQENDE P--CK--------EVLRPRRM---LQQKIQEAAAKYKHPVVKRC-CLDGA----HRND-D --ETCEQRLAR-----------VTKG----PHCARA-------FNECCSIARQFRDK--- ----------HSHKNIQLGRLHTKTLLPVSKPEIRSYFPESWLWEVHHVS---------- ----------KRNQLQLVLPDSLTTWEIQGVGIS---NSGLCVAD-TLKAKVFKDVFLEM NIPYSVVRGEQIQLKGTVYNYRTSGMMFCVKMSTVEGICTSGNLA----ADHQGTKSSRC VRQKVE-GSSTHLVTFSVLPLETG-----LHSINFSL-------------ETSFGG--ET LVKTLRVVPEG-VKRETHAGVTLDPRGIYGVVSRRKE----------------------- ---FPYRIPLDLVPKTNVERIVSVKGLLIGEVLS----AVLSKEGINILTHLPKGSAEAE LMSVAPVFYVFHYLETGNHWDIFSPNSLIKKQDLKKKLKEGIVSIMSYRNADHS--YSMW K---GGSASTWLTAFALRVLGQVNKY--VEHNQ-----NLICNSLLWLVENCQ-LENGSF KDDSKYQPIKLQGTLPVEAKENSLYLTAFTVIGIRKAFDL----CP--LLKISTALTKAE NFLL----ENTLPAQ-STFTLAIAAYALSLGDRTHPQFRAIASALKRAASVK-GGS--PP IYRFWKDGLQQ------HKDTSAPNAGTAGMVETTAYALLTSLNLKE--------MNYVN PIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVK-----QLQL-DMDINVSYKHKGN ----FQNYKITEKNFLG---KPVEVP----LDDDLVI-STGHSNGLATVHVATVVHKTST SEE-ICSFHLKIEAQDIEASY--------------------------------------- -------------------------------------------------------YSDLG YKRIIACASYKASGE-ESSSGSSHAVMDISLPTGISANQDDLRALVEGVD-QLLTDY-QI KDGHVILQVNSIPSTDFLCVRFRIFE-LFQVGFLSPATFTVYEYHRPDKQCTMFYST-SN TK-LQR-VC-------EGTLCKCVEADCGQMEKELDL----------------------- -TISAE---------------------------TRKEKACKPEIVYAYKVSITSITE-EN VF----VKYTATLLDVYKTGE---AIAEKGSEITFIKKTTC---------------ANAD LLKGRQYLIMGKEALQIKHN-FSFKYI--------YLLD---------SWTWIEY-WPS- -DTTCPSCQA-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FS------------------------------------------ ---------------------------------------ANLDEF-----AEDIF----- ----------------------LNGCENA----------------------- >XP_015815864.1 PREDICTED: complement C5 isoform X1 [Nothobranchius furzeri] M----------------KVLALLVCVW------------CLGW---RTNAESKSYVITAP LSLHLDAVETVFVQLFGYTSEVPVYVFLRTSMA-VNNKVLF--QDVVRLNSLNGYQGVAN VRLFPNKLGKD-----VNQVVLHVQTS-----DINQHQPIPISRTNGFLFIQTDKPLYTP NQKVKVRAFSMNQELRPA-NRSVFLT--FKDP-EQVPVDVVEMIDVNNGIPSMQNPFKIP VKPKLGIWTIEAAYSDDFNTK-ATTDFEVKEYVLPSFSILMNPQTNHISFSE---FRRFT FRISARYLHGAPVTEGLVYLRYGYV--RGTGAPVI------IPKSFSQERL--------S QTGEVDVTVDMQTVL-QKHDGPKDISSLV--GSYLYIAVLVKEDTGGITQEAEFASVKFV RSPYHLSLISTPPFIKPGLPYNIKVLVKD-HLDKPMS-KVSVQLTEKQLVMNGGST---V DMSCQGSGD---------SSSDGLVYFICHPLKNSARAVLKFQTADPTLPSS-------- ----SQASLTLEPVAYQSP-NQRYLYIDTPMF--GRSLEVGRY-TNIHVYTATPS-YLNI RTLNYLVLSKGKVVYFRTLNFVN------------------TSDNKQT----------LN FQVTSSMVPSIRLLVYYVLHGEGTTELVADSVWMDVKDKCLNGLQMDVSL------RSE- THKPKDNVNLDIRANQ--DGLVALSAVDSALFTLRP--YYKDPVFTVLRHI-EKTD---- --QGCGGG----------------------GGKNNADVFRLAGLTFMTNANAHPLS-STE P--CT--------AVVRPKRAL--SQEEINNKARRY--GRFKTC-CERGM----DYIPKS --VTCERYAQQR--------LRSKPP----ADCIKA-------FRECCEFFQQSQDQ--- ------------NDVLVLARTALGANFDLAP-MVRSYFPESWLWEVQRTSS--------- ----------GQLPIRKSLPDSLTTWQIKAVGMF---QNGMCVAD-PVEVSVNLPLSVDV PLPYQVVRGEQVELRGSVYNQKEDSITYCVTLTAGPALCLLQSHP----VNDAGLHSTTC TFRHLL-AGGVGVVNFTVLGLEPG-----EHTLTFTL-------------KTRAGV-ADV VEKLLRVVPEG-VRQEVNFGGILDPQGLYGSEKRTVV----------------------- ---LKNRLPENIVPKSDVERLLTINGELPGDVAT----VLLNPEDLKQLISLPPGSAEAE LQGLLPLIQVYQYLETTGSWDVLGGDVGKMSGDLRQKIKEGLVAISSFRNGDSS--YSMW I---KSEPSTIVTAEMIRALSMADAF--LSVDH-----QSLSDSVGWLIRRTQ-KEDGSF AEKSSSRLIQILGGG-EEEVEQSVFVTSVALIALHRATSIRDQILR--LRSHEASKRSAA NYIS----QHALSVR-SVYVRALATYALTLQDSNSEEVSQLITSLEGLARQK--GN--PV TLRYWQESSV-------TTDWLKPDKSSGQTVETTAYVLLTMLLKAR--------ISYAN PILAWLTQDQHYGGGFFSIKDAVLTLEALTLYKSVMT-----RSVL-NQEINIRYKVKGP ----LGRVSLSQTRPVA---TPIQVT----KNDDITV-TTGYGRGVSSVKLKTVFYQTTA STQPRCNFDLTIEVVGPSVSD--------------------------------------- -------------------------------------------------------NPSMK APHLVACVKYRPPPN-EVATESSLAVMKIQLPTGVEPYLEDLRQFRDDEE-SLVSHY-EL QGSTVIIQMDWVPSQVFVCVGFRVRT-GFKVVGATESWISVTEPQEKGSLCSKQFSS-EQ QK-LQR-LC-------VDHQCQCMTAACASYRGTTTN----------------------- -TLTLE---------------------------KRIEEICKEQIKFAYKLTVTSSAA-EG DF----MTYTATVDQVLRPSN-EFEAVSSGTEVDLVKKATC---------------SSVD LHDNRQYLVMGSSGSEVTHN-NGFRSV--------PPWS---------VDVLVSR-GAD- -GFWSISGTG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------WTLMPWW--SSGLRVA----- ----------------------LQSVRTTFPRWRN----------------- >XP_030272007.1 complement C5 [Sparus aurata] M----------------KLCVLLMCVC------------CLCW---RTEADSRTYLITAP LSLRLDAVETVLLQLFDFTDEVTVYVYLKTSMA-ANHVILA--QEVVTLNAANDYQAAAR VRLFPGQLDKS-----VSHVILHVQSP-----VINGHLSIPVSRTNGFLFIQTDKPLYTP DQSVKVRAFSLSQELRPA-QRSVFLT--FRDP-QNVIVDIVEMIDANNGIPSMQNPFKIP IKPKLGIWSIEASYSDNFTTS-ARTEFEVKEYVLPSFSIQMEPESNFISYGK---FNSFN FKVSARYLHGAPVADGEVFLRYGYI--RGKNPPVL------IPSSVSRERL--------S STGEVDVTVNMEKVL-SKHDGPKDLNSLV--GMYLYVAVLLQEDTGGLTQEAEFAAVKFV KSPYSLSLVSTPPFIKPGLPYNIQVLVKD-HLDKPVH-RVRVRLSERQLFKGGGES---E QIPCPDSAN---------SQSDGLAVFICNVPSDGVRAVLKFDTADPALPAA-------- ----SQAALSLEAVAYHSP-NQRYLYIDPPLP--GRGLEVGRF-ARIKVYSATPS-YVPV KALSFLVLSKGKVVEFGSQKFIS------------------SADHRQT----------LS FLVKPSMVPSIRLLVYYILYGEGTSELVADSVWLDVRDKCVNGLQTEVSY------RVR- DYKPKERFQLDIRANQ--EGLVALSAVDSALFILRP--NYRDPVSTVLRHI-EQSD---- --LGCGGG----------------------GGRDSADVFRLAGLTFITNANANPLS-STE T--CT--------AAVRPKRAL--TEEQKKKKAHTY--GRAKTC-CENGM----KFIPKI --MTCQKFADQH--------Y-SKVP----LPCRQA-------FRECCEFMQQHLDQ--- ------------DQGLVLGRNALGADFDQAPSLVRSYFPESWMWEVQPVSP--------- ----------GQRSTVRTLPDSLTTWQIRAVGMF---NDGICVAE-PLLVSVNLPLSVDV PLPYQVVRGEQLELKGSVYNQQPDPITYCVTLTVGPALCLLQSQP---AAGGAGLHSTTC SWSRLS-AKEVGKVSFTVLGLEPG-----EHTLTFTL-------------KTRNGP-KDI LEKKLRVVPEG-VKKELMSGGTLDPQGRYGSEKRTVE----------------------- ---LKNNLPINIVPNTAVQRMLTVHGEVLGDVLS----VALSPEGIRQLVNLPAGSAEAA LDEVLPLIQVYQYLETARHWDILGGNIQENSRDLRRKIREGLVAISSFRRGDSS--YSMW M---NSKSSTWLTAQVVKTLSAADQL--VSVDHQSDHRQSLSESVAWLIRSSQ-QPDGSF TDASSFRANKVMAAG-ANAVDQSVYLTSFVLIALHKATSIKDPILQ--LQFQEDSKTSAA NYIS----QHASGVK-SLYVRAVATYALTLHDPNSMAASTQLLHLERKAQSK--GN--PV VLRYWKEANV-------TADWLKPDQSSAQTVEMTVYVLLTLLLKGR--------IQDAN PVLSWLTQDQHYGEGFYSIQDTVLTLEALTEYSTAVP-----RAVL-DQDINIRNR-KGS ----VGRVQLTQSRPVA---SPIQVT----NNEDITA-TTGYGRGVSTVKMKTVYYETTA SNQ-NCNFDITIEVAGPDTSS--------------------------------------- -------------------------------------------------------NPSMS APHIVACAKYNPPPN-ELSTESGLTVMKIQLPTGVDAYLEDLRQFRDAME-PSVSHY-EL QGHTVVIQMDAVPSDRFLCVGFRIRT-AFKVTGESESLFSVYEPQDKGSLCTKQFSS-QE QS-LQR-LC-------VGQQCQCMTAACAAYRGKIDA----------------------- -TLTAD---------------------------KRTDETCKPHIKYAYKVTVVSSAA-EG DF----MTYTATVVEVLKNSDKEFEAVSSGTEVDLVKKITC---------------SAVD IQNNKQYLVMGSSGSEVKLN-QGFKYR--------LPLD---------SEALVEL-WPT- -DCSSPECLD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------YV------------------------------------------ ---------------------------------------SQLDDF-----ALDLQ----- ----------------------LASCPAS----------------------- >XP_040179981.1 complement C5 isoform X1 [Rana temporaria] M----------------MILLQIALLI------------AVCG---RSQSQEQTYLVTGP RLWRIGAQETVVIQAFGQTENFPIKMSLL-SFP-DKRTTYA--VQSIDLTPANKFQGLIN LQIQPKDLPRKDGE--MQYIYLQAQSK-----SFTKEEKVAVIYENGHLFIQTDKAVYTP DQSVKIRVYSMDEELRPA-RRRVTLT--FLDP-EKVKMDIITQDDVT-GVISF-PDFKIP ANPRYGLWSIEAAYESDYVTS-SLVKFEVKEYVLPRFFVTIEPERNFISHDT---FKDFS VTVKAKYYYGRIVEKGKAFIRYGL---LINGEKKL------MAKSIDVLQM--------- TNGEAVFQFNSERSV--AELQYSSLEELE--GALLYITATVEEEEGAQSEESENANVKYV LTPYRLTLIATPLFVKPTLPYHIKVQVKD-TLENPAS-RIPLVLTGEFAKENGEST---P V-----DNGEAITQ---KTDIKGTSMFVINIPADVTALDFRIKTDDPNLQEE-------- ----NQALAEFKATSYKSL-TKSYLYIDWARE--SKVLQVGGF-LNVNIFPKSPY-LHKL THYSYLIISKGKILKYDTVERL-------------------SGSVSQY----------LN IQITVNMVPSFRLLIYYIVTGESTAELIADSIWVEVQENCLNNQKVKLSV------PSD- TFKPKENVTLNVNALT--GSIVALSAVDVSIFDVTK--KAQRPLERVLRKI-EDSD---- --LGCGAG----------------------AGQNNVDVFQTAGLTFLTNANIQATQSLDW K--CN--------AILRSKRS---LEDEIKKEARKFQNESIKRC-CMDGG----FNLIKE --NECKKGVER-----------VQKLKPNFQMCAKV-------FAKCCKLAEGLKAQL-- ---------DKEKKELQLGRMYIKTILNLDEPEIRSYFPESWLWEEHAITDR-------- ---------SSSKKVDISLPDSLTTWEVQGVSMS---DKGICVAD-PLTFTVFKDLFLDV QLPYSVVRGEQVQIKVIVYNYQPYKVMGCVRVSVGKEVCLVSDSS----SSRN--GSPRN CRDEIH-PLSPKTFTYNLLPLELG-----LHPIIFTL-------------HAP-KR--EI VIKNLRVVPEG-IQEENSMGFTLDPQGIRGIMKRNQD----------------------- ---VAFKIPSSIVPKSKISRILSINGNILGEVID----TIVSGKSIQTLVSIPKGSAETD LMRVAPIFYVYHYLQTKNEWSLLGPNTFMIQIDMQKKLKDGVSSILAFRKGDHS--YSLW R---DSDPSTWLTAFALRTFGEVHKY--VPLDH-----MSVCNSLIWLIEKCQ-SKDGSF QEKSSSLPIKLQGTIPREAAEKTLYLTAYVVIGIQKSLNM----CP--LAQIDNALRLAV DYLS----KQASSAQ-SMYTMAVCAYALQITDTTLQSKLQVMTKIKGEALTK--GSSFPP VYRYWKDTLK-------KFDSVTPSTETAVMVETTAYTLLAVLKSGD--------YEYAK PVVRWLKEQQRYGGGFFGTQDTVIALEALTEVAILEK-----KLNL-NMDVTISYRRAGL ----FKNYQLTERNPFT---KPVEVP----ILEDLLI-STRSAYGIATGNVKTVYNIISP PQE-NCRFDLKIQKKLPSEDQ--------------------------------------- ---------------------------------------------------SIFSDDTSQ ALLLEACAKYKPNKN-E-NPESGQAVMEITLVTGLLADEKSLNELVNRVD-QFVVDY-SL EDGKVVLHFDWIGSDEYVCATLLVRK-MFKVSLISPGIFKVYEFRAPDQACTAFYNPYAD DN-LVR-VC-------TGETCKCIEGECPKLKTKLDM----------------------- -TTTED---------------------------QRKNVACKGDITYVYKVQIVQLEE-DG DF----VKYTAKILDIFKEVT---ALVKANKQIRFIKKKTC---------------SSFD LENGQQYLIMGKDGIQIREE-REYKYE--------YPLD---------SNSWIEW-WPD- ASCTSRQCKP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------DLLEGV-----TESIL----- ----------------------LEGCQ------------------------- >XP_020749261.1 complement C5-like [Odocoileus virginianus texanus] -----------------MGLWGILCFL------------IFLG---KSWGQEQTYVISAP KVFRVGASENVVIQVYGYTEEFDATISIK-SFP-DKKVTYS--SGHVTLSTENKFQNSAT LTIAPKQLSERQSS--VSHVYLEVISK-----HFSKAKKMPITYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVYMVEENDYT-GIISF-PDFKIP SNPKYGVWTIQAKYKEDFSTT-GTAYFEIKEYVLPHFSISIEPESNFIGYKD---FTSFE ITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEM------MQKAMQSTTL--------- INGMAQVTFNSETAV--KELSYESLEDLN--DKYLYIGVTIIESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFVKPGIPYSVKVQVKD-SFDHLVG-GIPVTLSAKTLDVNQETS---D L-----ESKKSVT-----RSSDGVASFVVNLPSEATVLEFNVKTNDPDLPDE-------- ----NQASKDYRAIAYSSL-SQSYLYIDWTEN--YKHLLVGEH-LNIVVTPRSPY-IDKI THYNYLVLSKGKIVHFGTRDKL-------------------SDSAYQS----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSP------STD- TYSPGQRVSLNMETEL--DSWVALTAVDSAIYGVQR--TAKRPLERVFQTL-EKSD---- --LGCGAG----------------------GGRDNADVFYLAGLTFLTNANADNTQENDE P--CK--------EILRPKRM---LQKKIEEEAAKYQHIRVKKC-CYDGA----HRND-Y --ETCEQRAAR-----------IKIG----PRCVKA-------FKECCAIATQFRAE--- ----------ESHKNMQLGRLHIKSLLPVTKPEIRSYFPESWLWEVHHVP---------- ----------KRNKLQFVLPDSLTTWEIQGVGIS---NSGICVAN-TLKAKVFKSVFLEM NIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPG----IDPQGRRFPKC VPQRIE-GSSTHLVTFTVLPLDTG-----LHNISFSL-------------ETSVGN--EI LVKTLRVVPEG-VRRESYAGVTLDPQGIYGTITRRKE----------------------- ---FPYRIPLDMVPKTKVKRTVSIKGLLIGEIMS----AVLSQEGIDILTHLPKGNAEAE LMSVVPVFYVYHYLEAGNNWNIFSTNSLTQKQNLKTKLKEGMVSIMSFRNADYS--YSMW K---GGSASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEKCQ-LENGSF KENSDYQPVKLQGTLPVEAQEKTLYLTAFAVIGIRKSFDI----CP--LEKISTAVSKAD NFLH----ENALSTQ-SAFTLAIAAYALSLGDKAHPQFRSIVSALKKKAFVK--GN--PP IYRFWKDDLQ-------QKDSSAPSTGTARMVETTAYALLTSLNLKD--------MNYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVR-----KLHL-NMDIKVSYKNKGD ----LYHYKISEKYFLG---RPIEVP----LNDDLVVLTTGQNSGLATVHVKTVTHKIST SEE-VCSFHLKIETQEIEASS--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKLGSE-ESSSGSSHAVMDISLPTGVSANPEDLKALVERVD-QLLTDY-EI KDGHVILQLNSIPSDEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SY TK-LQK-VC-------EGVTCKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKETACKPEIAYAYKVEITAVTE-EN AF----VKYTATLLDIFKAGE---AAAERDSEITFIKKTTC---------------SNAN LEKRKQYLIMGKEALQIKYN-FRFKYI--------YPLD---------SSTWIEY-WPT- -DSRCPSCKR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ESLGEF-----AEDIF----- ----------------------LNGCEST----------------------- >XP_043309645.1 complement C5 [Cervus canadensis] -----------------MGLWGILCFL------------IFLG---KSWGQDQTYVISAP KLFRVGASENVVIQVYGYTEEFDATISIK-SFP-DKKVTYS--SGHVTLSTENKFQNSAT LTIPPKQLSERQ-R--VSHVYLEVISK-----HFSKAKKMPITYHNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMVEENDYT-GIISF-PDFKIP SNPRYGVWTIQAKYKEDFSTT-GTAYFEIKEYVLPHFSISIEPESNFIGYKD---FTSFE ITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEM------MQKAMQSTTL--------- INGMAQVTFNSETAV--KELSYESLEDLN--DKYLYIGVTIIESTGGFSEEAEIPGIQYV LSPYKLNLVATPLFVKPGIPYSVKVQVKD-SFDHLVG-GIPVTLSAKTLDVNQETS---D L-----ESKKSVT-----RSSDGVASFVVNLPSEVTVLEFNVKTNDPDLPEE-------- ----NQASKDYRAIAYSSL-SQSYLYIDWTEN--YKHLLVGEH-LNIVVTPRSPY-IDKI THYNYLVLSKGKIVHFGTRDKL-------------------SDSAYQS----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNVEEKCGNQLQVHLSP------STD- TYSPGQRVSLNMETEL--DSWVSLTAVDSAIYGVQR--TAKRPLERVFQTL-EKSD---- --LGCGAG----------------------GGRNNAEVFYLAGLTFLTNANADNTQENDE P--CE--------EILRPKRM---LQKKIEEEAAKYKHIMVKKC-CYDGA----HRND-D --ENCEQRAAR-----------ITIG----PRCVKA-------FKDCCAIASQFRAE--- ----------ESHKNIPLGRLHIKSLLPVTKPEIRSYFPESWLWEVHHVP---------- ----------KRNQLQFVLPDSLTTWEIQGVGIS---NSGICVAN-TLKAKVFKSVFLEM NIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPG----IDSQGRRFSRC VPQRIE-GSSSHLVTFTVLPLEIG-----LHNISFSL-------------ETSVGN--EI LVKTLRVVPEG-VKRESYAGVTLDPQGIYGTISRRKD----------------------- ---FPYRIPLNMVPKTKVKRTVSIKGLLIGEIMS----AVLSQEGIDILTHLPKGNAEAE LMSVVPVFYVYHYLEAGNNWNIFSTNSLTQKQKLKTKLKEGMVSIMSFRNADYS--YSMW K---GGSASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEQCQ-LENGSF KENSDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDI----CP--MEKISTAVSKAD NFLH----ENALSTQ-SAFTLAIAAYALSLGDKAHPQFRSIVSALKKKAFVK--GN--PP IYRFWKDDLQ-------QKDSSAPSAGTARMVETTAYALLTSLNLKD--------MNYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVR-----KLHL-NMDIKVSYKNKGD ----LYHYKISEKYFLG---KPIEAP----LNDDLVVLTTGQNSGLATVHVKTVIHKIST SEE-VCSFHLKIETQEIEASS--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKRGSE-ESSSGSSHAVMDISLPTGVSANPEDLKALVERVD-QLLTDY-EI KDGHVILQLNSIPSDEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SY TK-LQK-VC-------EGVACKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKETACKPEIAYAYKVEIIAVTE-EN AF----VKYTATLLDIYKAGE---AAAERDSEITFIKKTTC---------------SNAN LEKRKQYLIMGKEALQIKHN-FRLKYI--------YPLD---------SSTWIEY-WPT- -DSRCPSCQR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------KNLDEF-----AEDIF----- ----------------------LNGCESA----------------------- >XP_004004015.2 complement C5 [Ovis aries] -----------------MGLWGTLCFL------------IFLG---RSWGQEQTYVISAP KVFHVGASENVVIQVYGYTEDFDATVSIR-SFP-DKKVTYS--SVHVTLSAENKFQNSAT LTIQPKQLSERQSS--VSHVYLEVISK-----HFSQAKKMPITYDNGFLFIHTDKPVYTP HQSVKVRVYSLNDDLKPA-KRETVLT--FIDP-EGSEVDMIEENDYT-GIISF-PDFKIP SNPKYGVWTIRAKYKEDFSTT-GTAYFEVKEYVLPHFSISIEPESNFIGYKD---FTNFE ITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEM------MQKAMQSTTL--------- INGMAQVTFNSETAV--KELSYESLEDLN--DKYLYIGVTITESTGGFSEEAEIPGIKYV LSPYKLNLVATPLFVKPGIPYSIKVQVKD-SFDHLVG-GIPVTLSARTFDVNQEIS---D L-----ESKKSVT-----RSSDGVASFVVNLPSEVTVLEFNIKTEDLDLPEE-------- ----NQASKDYRAVAYSSL-SQSYLYIDWTEN--DKHLLVGEH-LSIVVTPRSPY-IDKI THYNYLILSKGKIVHYGTRDKL-------------------SDSAYQS----------IN IPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSP------RTD- TYSPGQRVSLTMETEL--DSWVALTAVDSAIYGVQR--TAKRPLERVFQTL-ETSD---- --LGCGAG----------------------GGRDNADVFYLAGLTFLTNANADHTREDDE P--CK--------EILRPKRM---LKKKIEEEAAKYKHINVKRC-CYDGA----HRND-D --ENCEQRAAR-----------IKKG----PICIKA-------FKECCAIASEFRAN--- ----------KTYKNIQLGRLHVKSLLPVTKPEIRSYFPESWLWEVHHVP---------- ----------KRSQLQFVLPDSLTTWEVQGVGIS---NSGICVAN-TLKAKVFKSVFLEM NIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPG----TDSQGRRFSKC VPQKIE-GSSSHLVTFTVLPLEIG-----LHNLSFSL-------------ETSVGN--EI LVKTLRVVPEG-VKRESYAGVTLDPQGIYGIISRRKE----------------------- ---FPYRIPLNMVPKTKVKRTVSIKGLLIGEVMS----AVLSEEGIDSLTHLPKGNAEAE LMSAVPVFYVYHYLEAGHNWDIFSTNSLTQKQNLKTKLKEGMASIMSFRNADYS--YSMW K---GGGASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEKCQ-LENGSF KENSDYQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDI----CP--LEKISTAVSKAD IFLH----ENALSTQ-SAFTLAIAAYALSLGDKSHPQFRSIVSALKKKAFVK--GN--PP IYRFWKDDLE-------QKDSSAPNTGTARMVETTAYALLTSLSLKD--------MNYVS PIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLGR-----KLRL-NMDVKVSYKNKGD ----LYHYKMSDKYFLG---RPIEVP----LSDDLVVLSTGQSSGLATVRVKTVVHKIST SEE-VCSFHLKIETQEIEAFG--------------------------------------- -------------------------------------------------------YSSSE YKRIVACASYKFSSE-ESSSGSSHAVMDISLPTGVNANPEDLKALVEQVD-QLLTDY-EI KDGHVILQLNSIPSNEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SH TK-LQK-VC-------EGATCKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKERACKPDIAYAYKVEIIAVTE-EN AF----VKYTATLLDIYKAGE---AAAERDAEITFIKKTTC---------------SNAN LEKRKQYLIMGKEALQIKYN-FRIKYV--------YPLD---------SSTWIEY-WPT- -GSTCPSCQR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FL------------------------------------------ ---------------------------------------ANLDEF-----TEDIF----- ----------------------LNGCANV----------------------- >KAF4019645.1 hypothetical protein G4228_011172 [Cervus hanglu yarkandensis] -----------------MGLWGILCFL------------IFLG---KSWGQDQTYVISAP KLFRVGASENVVIQVYGYTEEFDATISIK-SFP-DKKVTYS--SGHVTLSTENKFQNSAT LT---------------------------------------------------------- ------------------------------DP-EGSEVDMVEENDYT-GIISF-PDFKIP SNPRYGVWTIQAKYKEDFSTT-GTAYFEIKEYVLPHFSISIEPESNFIGYKD---FTSFE ITIRARYFYNKVVNEADVYISFGIRDNLKDNQKEM------MQKAMQSTTL--------- INGMAQVTFNSETAV--KELSYESLEDLN--DKYLYIGVTIIESTGGFSEEAEIPGIQYV LSPYKLNLVATPLFVKPGIPYSVKVQVKD-SFDHLVG-GIPVTLSAKTLDVNQETS---D L-----ESKKSVT-----RSSDGVASFVVNLPSEVTVLEFNVKTNDPDLPEE-------- ----NQASKDYRAIAYSSL-SQSYLYIDWTEN--YKHLLVGEH-LNIVVTPRSPY-IDKI THYNYLVLSKGKIVHFGTRDKL-------------------SDSAYQS----------IN IPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNVEEKCGNQLQ--------------- ----------------------------------------------VFQTL-EKSD---- --LGCGAG----------------------GGRDNAEVFYLAGLTFLTNANADNTQEN-- --------------------------------AAKYKHIMVKKC-CYDGA----HRND-D --ENCEQRAAR-----------ITIG----PRCVKA-------FKDCCAIASQFRAE--- ----------ESHKNIPLGRLR-------------------------------------- ----------------------------------------ICVAN-TLKAKVFKSVFLEM NIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMHPVEGICSSGSPG----IDSQGRRFSRC VPQRIE-GSSSHLVTFTVLPLEIG-----LHNISFSL-------------ETSVGN--EI LVKILRVVPEG-VKRESYAGVTLDPQGIYGTISRRKD----------------------- ---FPYRIPLNVVPKTKVKRTVSIKGLLIGEIMS----AVLSQEGIDILTHLPKGNAEAE LMSVVPVFYVYHYLEAGNNWNIFSTNSLTQKQKLKTKLKEGMVSIMSFRNADYS--YSMW K---GGSASTWLTAFALRVLGQISKY--VDQNQ-----NSICNSLLWLLEQCQ-LENGSF KENSDYQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDI----CP--MEKISTAVSKAD NFLH----ENALSTQ-SAFTLAIAAYALSLGDKAHPQFRSIVSALKKKAFVK--GN--PP IYRFWKDDLQ-------QKDSSAPSAGTARMVETTAYALLTSLNLKD--------MNYVN PVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVR-----KLRL-NMDIKVSYKNKGD ----LYHYKISEKYFLG---KPIEAP----LNDDLVVLTTGQNSGLATVHVKTVIHKIST SEE-VCSFHLKIETQEIEASS--------------------------------------- -------------------------------------------------------YSGSE HKRIVACASYKRGSE-ESSSGSSHAVMDISLPTGVSANPEDLKALVERVD-QLLTDY-EI KDGHVILQLNSIPSDEFLCVRFRIIE-LFEVGFLSPATFTVYEYHRPDKQCTMFYST-SY TK-LQK-VC-------EGVACKCIEADCGQMQAELDL----------------------- -TISAA---------------------------TRKETACKPEIAYAYKVEIIAVTE-EN AF----VKYTATLLDIYKAGE---AAAERDSEITFIKKTTC---------------SNAN LEKRKQYLIMGKEALQIKHN-FRLKN-------------------------------GE- -DRICPKCKGEDTPSESPGSLLSQEKGSPKFMEEHEVTSQAAHLNLLLGFMKQWKAQLGS GLGYGPIALERNLSDLQLQGAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLTELEG KLCVFENIVAVLNKEVEASHLALAASIHQSQLDREHILRLEQRVLELQQTLAQKDQALGK LEQSLRLMEEASYDGTFLWKITNVSRRCQESACGRTVSLFSPAFYTAKYGYKLCLRLYLN GDGTGKRTHLSLFIVIMRGEYDALLSWPFRNKVTFMLLDQNNREH-----AIDAFRPDLN SASFQRPQSETNVASGCPLFFPLNKLQSPKHAYVKDDTMFLKCIVETN---T >XP_041428292.1 complement C5-like isoform X1 [Xenopus laevis] -----------------MIWLNVALLL------------ALHG---YCLCQEKTYLVTGP RTWRIGALETVVVQAFGQHGDFSIRINLL-SYP-DKKITYA--TQHLVLNNGNNYQGLVK LMIQPQDFPKHSASDPMPFIYLQALSN-----AFNKEEQVPVSYRNGFLFIQTDKPFYTP DQSVKIRVYSMDEELKPG-RRKVVLT--FKDP-EEVKVDTIEEDDLT-GIISF-PYFKIP ANPKFGMWSIEAAYGKDFTTS-GTVKFEVKEYVLPKFLVSIEPEQNFICYDK---FTEFY ITVRARYYYEKLVENAKVYIRYGL---IQDGERKM------LPKSIDLLTM--------- NNGESVFQLNSQKAL--QELGYSSLEEVA--GSYLYITVSVEESTGRV-EESENADVKFV LSPYTLKLVGTPLFVKPTLPYYIKVQLRD-TLDKPVG-NIPLTLSGDMVKEDGSPE---D LII---QQQRIST-----DRNLGIGLFILNIPSDIVSLDFTIKTDDSSLPEE-------- ----NQATATHVAVSYQSL-TKSYLYINWARE--REVLHVNNF-LNVQLVPNSPY-IAKL NHYSYLVISKGKILQFGTVPRV-------------------PGSNSQS----------LN LHITADMVPSVRLLVYYIVTGDATAELVADSIWVDVVESCVNHQSVQLSK------REN- IMKPGQTFSLKISALP--KSLVALSAVDTALYDVGK--RFQRPLETVLRKI-EESD---- --LGCGAG----------------------AGENNADVFRLAGLTFLTNANIQASQKYAL K--CN--------EVLRPKRSF-NFKDEVDKKASTYTDRNMKKC-CYDGV----KCFRDE --NDCAAGINR-----------VSKRYS--KKCINA-------FEVCCLFAKSLQEKM-- ---------DAQIQDVGMGRMYLRTVFDIDEPQIRSYFPESWMWEEHLLDNR-------- ----------GEKTLSVTLPDSLTTWEFQGVGMS---DKGLCVAD-QFKVTAFKDFFIDV QLPYSIVRGEQIQIKVVVFNYRNSDAKGCVTVSVGKEICLFSDTS-----PRS--GSREC YKHTLS-ATSLTPFTFSLLPLEVG-----LHPISFTL-------------SSS-SQ--ET VKKTLRVVPEG-IKKERNAGFTLDPQGIRGVARRRQE----------------------- ---ISYKIPSNIVPKSKVSRILSISGNILGEVIN----TVVKSEGINYLVSLPKGSAETE LMRVVPIFYVYHYLETNKRWDLLGTNILAAQIDMQRKMRDGVNSILSFRGKDFS--YSIW K---EGKPSAWLTAFALKIFGEMEKY--VYVNK-----MSVCNSITWLLDKCQ-LRDGSF IDQSGYQPGKLQGTVPSESEERSLYLTAYVFIGIQKSFHM----CP--LEEVKEGLRRSE EYLS----KNIRRAK-STFTLAIMGYALASWDVSLASVRYVKGALEREAYVIESGD--LP IQRYWKDSLK-------KVDATTPSVETARMVETTAYALLMYLKLAL--------KDYYN PVVRWLKEQQRYGGGFYSTQDTAIALEALTEVSIVDK-----KLTL-NMGVQVSYKKSGD ----FKNYRLTETSSFT---RPEEVP----LPEDIIV-STSSANGIASVHVQTVYNIISP PQE-KCRFDLRIGKKLNWKPRQ-------------------------------------- ---------------------------------------------------SIFDSERFG VIPVEACARYKAADN-D-PSISGHAVMEITMVTGLTVDENELEELMQRVD-QFVTAY-DL ENGKVMLHFDGIPSDEYVCVTLLAWE-QFKVAVLSPGIFSVYEFHAPEEECTTFFNPLTT NN-LEK-LC-------TGDKCKCIQATCPTAQRKIDT----------------------- -SITAN---------------------------ARREVACKADVTYAYNVLVISSVE-DG DF----IKYTASIQDIYKKGG---DFVKAKKEVKFIKKKTC---------------TDIE IDQGEHYLIMGKEGIQIRIG-FEFLYE--------YALD---------SDTWVEW-WPP- -ACNTAACEQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FI------------------------------------------ ---------------------------------------DTLSEF-----SDKML----- ----------------------FDRC-------------------------- >XP_038046848.1 complement C3-like isoform X1 [Patiria miniata] MQ------------------AFLIFFA------------ALQM---LVTAQAAQYFIVAP NLVRVDVQETILVSVLGT-GENQIPVTLYFQLT-GSNDRIS----ETTVFVRQDESQEAR LRIRRDQLPQLQTSG-QQFVTLVASAN-TAQLSIDDRRVILLSYQAGFVFIQTDKPLYTP KQRVDIRVVALDQDMVPV-NNEMQVD--IISP-DDIIVERYKQRPVD-GFLT--LSFVFP SNPVFGNWSVSAYYGHQFKAS-STVQFEAKEYVLPKFYVEVAPQSLYIVPET----QNLI SKVTARYIFGEPVV-GNFYVKYGV---LEDDGSLM-------DLQSKEGRL--------N EVGEAFQDLDMNDVK-----VENWAETLM--GKRLVIQAFVTDTATGETINTNNTQVTFS RTPYKFNWDLTQRYFKKGLSFSVKANVQF-MSGLPAE-DVPVIASATALQGGRRVDL--E GAQAGAQAGGGREHLEKISGPQGEVDFRLDVPAAATEITITLRTNNPDLVNA-------- -----NTEGTITVLAQASS-NNEYLVVRVPSGDIRRVQRIGRQ-STVEVQLTHP---DNV GVLNYFVIAGGRIVHKGAKNQV---------------------NLNTA----------LG FEVTHEMAPSSRVVAYYT---DANGNVVADALLIDVEEKCKNPIGLSFLGLPSEGSTYK- SERSGQNVQLEILAKE--DTNVGLVAVDEAVFKLRN--YHRLTQKKVFKRM-AGYD---- --LGCGPG----------------------GGQTSATIFKNAGVTVMTNAQLDVPHREAL G--CPE-------PVRRARRSA---NDTEREQILSNYEGVNREY-CEKGM--RELSGSVQ --LTCAQRAKLM-----AGRKGLQVD----SPEIRA-------FFDCCSVLESSSDRGRV DAGAGG--------------------VNLEDILVRSNFPESWLFDNVITQSL-RSDD--- --------DDGRVLYPTTLPDSVTTWVIEAVGVHMREVHEMCVAE-PIKLEVRPPFFLDI GMPYSVQRFEQIEIVASVFNYGDDELEVTVYLRGKEGLCSIAQPG----------EYSEG ITIQVE-AKKPASVKFVIVPLEVK-----NIPIEIVA-------------MDASGQHRDA IEKDLTVRPEG-YEKKISVPVTLDPANYRGSPAKQDGG-ADQFYFHSQNWGDQGEE--KQ IDFIRYSVNRNAIPGSHKAR-MSLVGNVLGSVID----TVLG--GLDKLLRIPGGCGEQT MLGLAPNVYVYTYLKHTDQF------TAALETSSERYVFNGVKHELTFRKNDGS--YAAF T---SRPSSTWLTAFVAKIFCKAKDF--AFVDD-----SNICKAMEWLITQRQSQDDGSF TERNAVIHKEMSGGV-----QGKASMTAFVLISLLECE------CD--AINKDDSVAAAT ALLE----DELPDLT-RPYAIAITAYALALANSIRAQEAI--QMLKDIAAYNAVSD---- -SRYWAADDSSFGGG--QKPYWYSARPKAIEVETTSYALLALLQMEE--------IQYTH AIVNWLTNQENYNGGFVSTQDTVMALQALSEYAYKVQ-----QYDI-DINCEVKCDESEF ----DEDFSLNPANALVREQRNIDVPD---MSQEMNVFISTEGAGMGQFKFEATYYIPEP DVT-ECDFDLLINEDENLQLD--------------------------------------- ----------------------------------------------------RPEDDNKE YLSYDIQVRYLR------GEKTGMAILDVGLYTGYKAVQEDLQTVMDNSG-GRVERY-EE TDHSVVFYFEDIPGLEAIRIQFRAER-EFNVGKVQPVAVHVYDYYNPTEECVKFISPKEG SN-LLGKLC-------VEDTCVCAAGKCAVDPIKKGR----------------------- -DYKVY---------------------------DMTQMACASKAHFAYEVTVTDVED-KG NF----QFYTMTIDAPLKQGL---DHVVKDATRVFAKSKSC---------------DTPD LQMTK-YLVIGSGGLPTKDDVGQDIYK--------YVID---------DRTFFYE-YPT- -ILQVNKSKK-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------WQ------------------------------------------ ------RIH------------------------------AKLTEL-----KQELVN---- ----------------------GEGCAL------------------------ >XP_011661993.2 complement C3 isoform X2 [Strongylocentrotus purpuratus] MEGLKG-----------LIVAIFASMA------------VLVYSGSAQLQTREKIFITAP NVFRVGVNETVTVSVFNTDQDQDVEVTIYLEKR-ERTRGLAWPYSYTTVAVRRGTPVTTS VRVEPEHYSSPAEGG-NQYVYLVASAP---SLGFQEEKEVLLSSRSGYLLLHTDKPIYTP NQEVKIRMVVVDQDMKPS-SELIHLM--ILNP-QGIIVEQFRETRAVNGFMN--KTFTFN TEPMFGNWSVTVLHGLQFEKN-KTIKFEVKEYVLPRFTIKINTPDFILESSS---RESLD INFEAKHVYKKPVG-GNFHMEIGI---LQPDGIVV-------SKSTTVGTL--------- ENGIGTSSIYPRYNF-----GLDWFRSYE--GCRLNVEVVVTEASTGVTERAVDISTMIV RSPYRFRTGQTVQYFKPALPYEVQFELET-VLGKPAQ-YLDVNIEASALVQSRRLTLNHN MDPNANQQS---------TDANGRVRFIFNTTQDMSQINIRVSTEE-NIEQE-------- -----NAVFQFDANPYQSPADDDYLSISID----QTVFRVGDE-LYVVARTTAS---TPI DNLNLLFLSQGKVILAKSIDHM--------------------INNPER----------VF FSVSSDMVPMVRIIAYYI---NQLDQVVADSIALKIENTCKHHVAINIKEE----TNEEG AYLPETPVTLLVDAYP--TSYVGLLGVDKAVYALNN--KHRLSRKKMFEMM-QTYD---- --IGCGPG----------------------GGPTSPVIFKDSGLSVLTNALLAVPAREAL T--CQR------VSSSRRKRSATQCQSNSRSRIEYCLNQLERRCNCDDNLTTTKMFNRIQ RWCTCETIASK---------LASKLP----PYCPQATEQDIEDFSQCCELMNKWRIG--- -SAPLGVDVLDSMDSISIGEDSTD-TFEEFGMDVRSDFRETWLFDLIRVGAP-------- ----------GRASLDLQTPGSITEWSLQAVSVT--PTGGLCVTD-PLDVNVFKSLSIQL QLPYSVVRSEQIEVLATIYNYNAQGATVRVSFYNPKGTCGESTNP----------SQPAR RTVHVE-GFNSQSLKFVIVPVEIG-----DLPITVTA-------------TSDVGS--DG VQKILNVIAHG-VPQSVDHSVMLDPSGIYRQQRRSPRLRAAMMEDIQSDLLDTDNG--VQ YNILDLRPPENIIPGTESAV-LSLIGNMLGPILV----DPVA--NYGEWLAYPRGCGEQT MSIVAPTIFVLKYLQTMKLM------NDSLEEMAMDRISRGLASVLSHRREDGS--FTIW GTNVLYSSSTWLTSFVLKVFSHANTL--TPVDE-----NVTCKAAEWLVLNAQ-NPNGSF SELYKVHHTEMTGGI-----SGEASMTAYVLIALYEGHW-----CDGMHRDFPLALRNAQ SFLE----RQVKYLS-RPYAKAIVTYALALSRSAYASDSN--RMLRNDAIIL--GD---- GSRYWTPNEADLTNE--DLPNWYRFRPSAIAIETTAYALLAQLELGD--------ITYAG SIALWLSEQQNYEGGFISTQDSVLALQALTRYSEMAN----GGIDI-DLSCVVTSEVDES F---HYEHRFLTHNALVK--REVAVP----VGGRLRS--RCEGKGTAKLAVRMKFNRLPS SQD-VCPFNVTYNAREARTGMDPISISRSRV----------------------------- ------GIAPRST----------------------------------TTSAQMARAKGDL VATIRFCARYTQ------NTRTNMGIIDVGLYSGFVLVSERLEDMVQTDHLHLVQRY-EV SQRSVIFYLDEIPADQDICMEFNARR-EIHVGNVQPVAIRVYDYYSPDKSCTSFYHPLQG NTQLPT-LCN------SADQCICPSERCALCTREPGK----------------------- ---------------------------------SLLDKACESSDNYALRVTMMSQER-IS GY----TVYIGNVTRVVRTGQ---DDVSPGMLRHFYIKERC---------------PCPR IKLNGEHTIIGSAGLSFISDTGADGYK--------YLLD---------DRSIVEW-WPT- -KLNKKKNLD-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------IQ------------------------------------------ ---------------------------------------TKLLNF-----EQDAQL---- -------------------------CT------------------------- >XP_031565662.1 complement C3-like [Actinia tenebrosa] MITQFKENAM----FTDSKMLLTLLTI------------ALLM---VGCSSKPSYVITAP NIFYVGVPQPIHVALFDVKWSHTIELELRVFLSYGETKVIA--SQRDRISADNGKLFSLT VGPEVSKFQSSQD---RGFVYLLSRIK-GPELHISKNTKVNVSYSDGVILIQTDKPIYTP KQTVKIRVVPLGFDLMPS-AKKINLV--VKNP-HGIGVRQWESLNTTLGFIS--KNIDIG SYALAGIWTIEAYYGHQFLYN-ASSRFEVREYVLPRFSVKISNPLYILPT-----LDSFK VKGTAKYTYGKPVQ-GTATVRLSI---AGNPQEKA------MSLSTSKIKL--------- VNGEFEHPIKMDRIK--TKLREKWFPE----GYRLHIEADVTEKSTGKTERAVERSVYFV TTPYLIEYVNTARYFKPGLPFSIVVIVKF-TNGQVAR-KIPMKVLVEAFKTDGRKI---N ASDPKQIQGSGFNWNRANTDDNGRAEFVINIARQVKELQIKVKTNLQNIPKE-------- ----QNAFKELVMDA--SE-SHELMKLRQT----NKPARVGTN-AVCDAVLTSK----TV DQLTYFVISRGQIIYSATIKKL--------------------LGIITT----------IS FKVTSPMSPSSRLFAYYVS--KETGRVVSDSILLEVEHKFPNPIFLKDSD------RRN- EEPPSMPYNIKIVGTV--GTKVGLLGVDQSVYLLSK--SNILTADSVFKKQ-EELD---- --LGCGAG----------------------SGRNSEDMFRNAGMVVLSSDIEVSGE---Q K--CKG-------EHKRERRSI---------------EEHRDFC-CSLGN----KTDTIK --RSCFRRLKDL----DVGIYNAKQR----YDCRKT-------FWMCCIHKFGRNESGIF ARARSG----VDLEALDFGDEQQE--DDALNIQTRQYFPETWINKELTISQHERNGECRA LLSQELQHKCGSAVLPVSLPDTMTTWVVQAIGVS--SSAGFGIAK-PLHITTFKPFFIYL SMPYSVQRGEEITILATLFNYKNYDVSVHLFLKGDQGFCSAAQPG--------KMTKLTT SKINIP-PQDTVAFPITIVPIKFG-----KVPIEVIA-------------VGDIGD--DR VLKTLNVVPEG-IEERLTQSYVLDPQELLKGRKEREEN-QQNKAEKLSFQSTQAHKDFKQ KNKIKLDIPKNAIPGSISAK-AYFTGNMIGQALT----NLAAG-QMVSLLQMPDGCGEQN MVRIAPNVYILHYLKKTNQM------TPELEKKKEKFIQEGYIHELNYRKKDGS--FALF KRE-YNKGSTWLTAFVLKVFCQASKLSGVNIDR-----NVLCQSAKWLIGN-Q-RQDGAF VEHANM--RSIQGGV----YTSDVTLTAAVVIALKQCQ------CG--MAEVNSAVERAV GFIE----KNVTTLA-DAYSLAITTYALVLANSPERFRAN--QKLIQKATYNQGSS---- -NRYWETGSK------------------ARNIETAGYALMAQVALNR--------FEYAG PIVVWLTKQRSFGGGFVSTADTCVALESIAKYSEQRQ-----KFQL-DLRIRMK------ ----NKIMRITKNNAFMQ--QEADLTEQ--TGDEVGI--QTSGSGVGQMQVDIKYNVPYK ENE-RCDFDVKVIATEEGSGRFISTTSSARNNVPARSRSRRALKAKSAKSKKRKDKNQAK KGKP--GKSKKNKKRRKNNRKKNQKKHQKKNQRKNKRRNKGKSKKREKNNRKPQSIDIPK KLVLRVCTKYRK------SGQTGMAIIEVGLVTGFSADEDTLIKLVEKKN-NSIERY-EL SDRAVVFYVNQIVNSRRICIAFHLIR-IFDVGIIQPVPIKVYXYYEPDTKCTLFYNLGSK RR-PVG-SC-------KKEKCKCTQGMCAEPDPYINN----------------------- ----ID---------------------------DLINEVCNVY-NYAFKGKVVGIDE-NT DTNPMAMTYQINITQIIKQGS---SIFQTQKAYLFNKPGIC---------------HYPD FEFEDEVFIMGKNKNGVQF------------------LD---------RDTFVKT----- ----LSRRQR-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ---------------------------------------NKIAKH--------------- --------------------IRHGKCT------------------------- >XP_039271128.1 complement C3-like [Styela clava] MK---------------LLQLCMQLFI------------AVLC---TRTSFGQNHLLIAP QILREGVRETAVLNLYNIDGRIDVVATVKLEG--VTNFEIK--NE----DATKPIIMKIK YDKPPGVLPSKR----RQYVELLVSAKQGNKKVYSGQLRMRLIESSGYIHIQTDRPIYRP EERVNVRVIALTQTQSPEVHREVEIV--IRIPLDNVGVEKKLLRMPKAKFID--TSFELP EYPVYGIWSIQARYTDEKVVRWSTTTFDVRPYVLPTFNVRVLLDDPYVLVKTDMSNEYIR GTITAEYSYGRKVS-GPYFLAAKL---NRPDIKSKF-LFYQMPELRRMAKL--------- RGGKQRFEIKATEVL--TVIGDDTFDDLEKEGATIEIDVAVTGEAEGVVESDRSRPIMFV RSPYQLDISRMSKYYTPRTSFEIKIDVLDSVTNSPVK-KVELILAGPKICGTLDCG---N DKCCSNGKCGECEPIVEESDENGQVNFKIGMDKDPVKRTYTIQTRKLGIPRE-------- ----NLAKLDFTLHPYISS-SGSYLQLSAV----EKIAEVGDKNFGIDVWYK-----SAP SRISYVIMARGAIISTGVHIPK-------------------KGSVNTN----------IK IEVKGEMVPSFRFFVYFF----SGKELLSNSLWIDVKDACKQELQVKVPA---------- QVSPSQVFNVEYIGSP--NAILGMSAVDRAAYFLYD--KGRLTRSSVFEAL-NLYD---- --EGCVRE----------------------GGKNAQHVFEEAGLQVVGGPYSAKDD-FTN H--CEA------KTLKRKKRSS---PKNIVAKLEKE--ALERKC-LMDGS----WENLYG --TSCVERAEA---------VRLKHS----FECAEK-------FLKGCEDYLKLKRR--- ----SG----RSIQANVAG-------FQAVANNVRSNFEENMLWATDVILG--------- --------PDGKYTRGVVAKDSITTFEFDTVSMH--EIDGFCVAP-TQNVTIFKDTFVQL KLPYSLKRMEQAEIRATVFNYATTSKRVTVHVKMGEDICSHFRQG----------KFDDV ITLEVD-ANEAEATSLVLMPLRVPDSKQVDIEVKITN-------------EDNVDI--DH VKRSILVLPEGEIKNDIKGTYAIDLKNKRPSYIDRFK----------------------- ---IELRFPKRYIPGSRQCW-IYPFSNYMGPIIEFDPVTKQPKNDIKNLIRLPGGCGEQT MLSMGPNVMAHKYLKLVGKMK----DGSAEETGSIDKMQKGFANELKYRTSTAPIVWSVF P---RRAPSVWLNAYVNKIFAQAKQFY-TAMDV-----GPICTSINWLVDQ-Q-NPDGSF DTGGRVIHQEMHGAV-----GSTLSLSAYVMMSLVESQSI----CPQYTKKVEISILKAT DYLEN--SENDRQME-QPYALSLVCFALSVSNPNNPFAKRMRKKLLSKINYSEDNR---- -LAFWKGAPLKTIEGTGTHAYWYKRNAKAIDVEATGYALLSILYAQSGEKVTQNILDVTR KIVLWIIQQRDEKGGFSTTQDTVVGLQALAEYMIWSSTVEPPTRDV-KIDLTISSATGSD WYDEPKRLHLDKSNENST--TPISIPSNVISGGELNI--QARGEGEGTLSYRCVYRTL-V DED-ACHFDISVSTEEDRIPLG-------------------------------------- ---------------------------------------------------HVAQGDGAE ILKLKLYISKPK------GEPSGQSIVEINLISGYEVMEDTLVKLSETVD-ASIERY-EI AKQKVFLYLSDI-TEVPKKLAFRISR-SVYVGRPEPSTVTVYDYYEPSVRCSKFYNVPEQ NLKLRTSSCTDKNGLGSEDICKCAEGGCLTCRTRKQQLE----------NTGCLEGMDGE CTICHDPDN----------------------CFDLAGTACKSDYVYEVKVTSDGVEDPSG VF----MDFAIQIVEVYKAGD--DLDVDRNQNRNFSVRRDCFESCRDDKALVDKDGKKEP FLKKDRTLLMIGNGVEMNYEDDDNILKGGELPRPHYRLG---------AGIFVERIYPT- TKCKKSKKKA-------E------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------EKKC-----------------------------RKLKKKTPKSTREECLK---H IA-------------------IHQSCNNLILLRKRIT---LGCDRERK---- >CAE1304902.1 unnamed protein product [Sepia pharaonis] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----TNVEIQLKGSP--RATVGLSAVDKAVYLIND--KNKLTRKLVKDTM-KLGD---- --LACSPG----------------------GGLHVGQVFYHAGFVIMTQDLDRTPATEIN NILCSLKQITAEVSFGRYRRAS-------------------DFC-CISGR----YRRG-- --HNCKVAWQEF--------SYYRKT----EFCRSA-------FMQCCNPAPELPPT--R KVITSGEVDESENERTPSARLRQD--AKSISPIFSLYFPESELFQEYRLNPS-------- ----------GLHKLNFTLPDSLTTWHIQGMSLS--DTSPFCVSK-PISLTTFKNVITKL NFPRVVKRLEQIYIKAVVYNYKTHPINVKVNFHETKEICSHAAPG-----------KPFP VKLSIP-AKDIGVAGVVIVPLKAG-----NFTIHIEVY-----------EVESNTL--EI IEKVLHVKYEG-VKKTNSFSLMLDPSGTYSGHKRHRRH-IFKDVTIPKNEISASQK--MQ RIIMKLTQPAEAIDGSAKGD-IVITGNILGSTIQ----TTLK--EPHKLLDKPYGCGEQT MIFLAPCVYILSYLNSTNQG------SQVIYENATRYIRLGILREQEFRKMDGS--YAAF D---QNPSSVWLTAFVLKVFCQASEF--EHVDS-----HLTKSAMTWLFQK-Q-RLDGSF IEDYPVIHQEMVGGV------NDRVMTAFVLISLMECGYKMH-PVE--IYRRKNEIDLAI RYLE----KQMAVTY-DTYDMAIISYALALADSSRKYEAR--IKLRSMAIENYDKG---- -YLYWRVGGYSNVTAK-KVSAWYHTEESYLSVEATAYALLTEMHYGE--------VEHVG PIVKWLIEQRNSAGMFKSTQDTVMALQALAEYGIKTI-----TPDI-NLFFNLTSSRAHL ----HKHLTVNKETSLWS-HIIPDVP----MNDEVLI--ESMGIGSAQMELNMWYYRPPT QRE-TCHFNVTHIIMPIQKDV------------------RRLI----------------K RGCPLCGESCRNL----------------------------------NGPILRNWDVSDQ TICMKIYLRYLG------TSDPGMVVLDMDLLTGYDTHEELLEQLK--LD-RLIAKYHKH GNSRLTLYFNTIPFNKEIEIKLLMFRTMIYMNRLMPAPINVYVYYNATESCTKFYQLSRE KD-LINLLCDS-----SKKVCKCAQRDCVTCYESMSEL---------------------- VNIKLK---------------------------FLEKKSCAKE-QIVMIVNMTSTFD-SS G-----TAYGFVQEDLSKT-----DIPDLEEHVAIFQKGIC---------------HCPH VKVGEIYLIMANKRVRTLDESNQYRHK--------FWVD---------SSGLM------- ----INKKNQ-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FV------------------------------------------ ------K--------------------------------GEIDIF-----EQKARS---- -------------------LSRQAFCG------------------------- >XP_006565503.2 alpha-2-macroglobulin-like protein 1 isoform X1 [Apis mellifera] MNKL-------------VFLVLFICSV------------TFLHCCDAASNVNRGYVFTAP KKLYAGEIETGCLSLHNLELPAHVHLELVFSFL-EGQEVLA----STSAVVKTGTETCLQ LAVPSPIYR-------TAILRLKIKFDKYPDYVIKSETDVEIEHDSLLTFVETDKPTYKP GQDVKIRILMLMHDLKPW-QKSIPEV-WIENP-SFVKVKQWTNVSTENGMAQ--LTFPLS PEPSLGSWHIKVMKKKPYPNLIHSTTFKVEKYVLPKFQMTINSPQYILAN-----VENVT WNICVKYSYGKPVK-GNLLLKLTP---QTPSWTRL----PNLPAIRYETKL--------- DKGDGCTDFVLSGSV--LGLAHWKMD-----PNNIVLIAEFTEAGTGIVETTISRTVVLH EALKLEYEHYTPKYFKFGLPYHGKLRVLR-YDDTPAP-NEKIQICLKVRGKIEWEK---D VVDCRDFR----------SSTDGFVDFVVP-PQHKNIVLLSFVATAVDYPTTYYSPEQRW RVFMNQPSTSITVNPWYSP-SDSYLTVARG----NQPIVCGEK-YSFNVMYTTSSNMNET ISFHYSINSKGSILIYGHVKHKPNRDTILNYFEFHNLLGTIESSANKTNKEAIVHRFPLS VKVTPSMAPVSELLLYYV---RSDGEIVATTYTIEVGHCFENKVKSTWHTD--------- AQIPGSPTQYHVEAAP--RSLCAISAVDKSTLFLSKSESNLMSSTQTFDAL-KRFH---- --------------------------------PTPKFYFPWENSRCKSAIGPEEMKEEIN H--LP--------QFLRSKRQTITYSKRVN------YVDAVQAF-VDFGV--IVMSDLVL ETRPCPWLFMEY--------TALSRQ----YISTNE--------------YMSMKDNSEF AVAAAA---------MDSGIGYVD-QNQAQMATLRSYFPETWLWELVPIGEE-------- ----------GKITIERTLPHTITDWVGYTTCIS--PTHGLGIAP-PTTITAFQSFFLDY NLPYSIKRGEIMRFKVSLFNYMHHSLPVKIKLEEMEKIDLHLSEP--------------T ASFCVK-PRDNIVHEYILKPRVIG-----EVNITVTAFVDIDYPEPCGSETVIFTQ--DV IVKPILILPEG-FPVEETKSALICPKDSSDDSSFM------------------------- ---WELTLPKDAVPDSGRAY-LNLIGDILGPALE----------NLDKLIKLPKGCGEQN MILFVPNNHVIKYLDAMRIN------KPDLRAKAIRNMEKGYQRELKYRFMDGS--YSAF E---EGESSIWLTAFVLKSFAQAASL--IHIDK-----YVLESSVSWITMN-Q-LEDGCF PVIGTVFHKSMKGGL--QEHGSSSALTAYILISLLESG----------VPLSPSVVNDAQ KCLE-----KGMNND-DLYTTVLTTYVLALLEHPKANSSM--KSLMNRATRY--KN---- -LIWWEDKSK---------------PSIGLSIEMTAYVILTLLKLGE------ENLSEAL KAVRWISKQRNSEGGFTSTQDTILGLEALTKYAMIVH-----HNNITDLSVLVTASKEV- ----DDVYKLQDENRVIL--KQIRLPI---LPTIVEI--FAQGEGCVLIQSNLKYNVASS TGS--DAFDLSAEVRSVGYGN--------------------------------------- ---------------------------------------------------------ECS LQEITICSRYKMA-----DEESNMALLEVGIISGYVPDRASLHSLLDPS--SKVKLF-EE DQDIVTIYFNKL-TGQKTCISFRIIQ-EYFIDHLKPANIKLYDYYQQELTVSTNYKIPS- -------ICSSAEP--VDEQLTTPNEMIIMKQLSFDESPMNSSFVVNNAELAIPDGMEGP IPVYVKLNTYDYKTEAATTTNGLPDLTSTFVTEDQTVPTVQTEDEEPIRIDTDNPSI-TN PL----MKEVLRIVKILKINE---TNVPSPTRIN----QSC--------------PICMD VLPSNISDIYCSANSAVKVAIRRFRKV-------RLLLDLHISREVKRLRAMIEFTLSP- -NCSCSPLDN-------PGS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------FA------------------------------------------ -------------LII-----------------------NKDNDFLTSGNQKQTLNDSFY IY-------------GLP-LVSGVPCKLAEIRASCLNEDNIQCTYEDPPAYG >NP_001366904.1 TEP (ThiolEster containing Protein) [Caenorhabditis elegans] MR---------------LLILNILFVVWQIHGVIGQSTNAAVVSTTAAPVKPATYMLVAP AVVRPDQPFSVCMNLLKQATDEDMIVRIEVRT--ERNETIA--ARVIS-NLKPGIAQTVS LSEMPAQSLTPRQSY-KLYIRGETLNA---ELIFENENELKYDQKALSVFIQTDRAIYRP ASLVRYRAIVVKSDLKPY-VGNATIK--IFDP-SRNLISQTIGVTLDRGVYS--GELQLA EETLLGDWFIEVETSNGVQ---DKSSFTVDTYVLPKFEVNIKTSSFITINDD------LS VFVDAKYTYGKGVA-GKAKVSLEL---PWHRWHAMVPTIIDENGVKKEEELMVERTVKLN RQGEAAVVFSNDELK-----RHKLLHEWG--GGSIRIVASVTEDITEIERNAT-HQISTF REEVKLDVEKQGDTFKPGLTYNVVVALKQ-MDDTPVKATLPKRVQVSTFYNYPYNH---D TSSLQEEKETKIV----EVDAHGTSVLTLQPPINCTSARIEAHYDIGGKDNF-------- --TATPIYSSLYVEAAVSP-TKSFLQLLADN---EGAVDVGKS-LSFSLKATQP-----L STITYQVMSRSNIVVSQQMT---------------------VNSEHAT----------IS FPATANMAPKSRLIVYAII--ESSQEVLVDALDFKVEGIFQNQVALSIDKQ--------- AVEPGQNVKFKVTSDK--NSFVGLLVVDQSVLLLKT--GNDITREKVEQDL-ENYDSNN- --VGGGFGGPRPWEAIDRKKRSIWRPWWGIGGSDAQSIFSNAGLVVLTDALLYREPQR-- -------------EFMSERRLN--------------TPGGLTVM-MMDGA---------- ---------------------------------------------------PGMAEAAFA APPMGG--------------------SSPPPPTVRKFFPHTWIWSDLNSTS--------- ----------GEVEMEIEAPDTITSWVASTFAIN--EENGLGVAPTTSKLRVFRPFFIQL NLPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDKDSGYDLLKKDGTVVRRDEVGQQNV RIVSVAGGGTSKAVYFPIVPSSIG-----EIPVHISA-------------IASQGG--DA VEMNLRVDPQG-YKVDRNIPFVIDLNNNSSDFSKN------------------------- ---LELIWPNDVVDGSQKAR-LDVIGDMMGPVLN----------NAHKLVQMPYGCGEQN MLNLVPNILVVKYLRATNRN------ESQLETKAIKFIEQGIQRELTYKRADNS--FSAF GDS-DKAGSTWLTAFVVRSFHHAKQY--AFVDP-----NVISRAVAFLNSQ-Q-MESGAF AERGEVHHKDMQGGA----QDGGVALTAFVLISILENG---------------MENGKAV TYLE----KHLDEVSGNAYTMAVVAYALQLAKSKQAGKAF--ENLKKHKIVEKSGD---- -VKFASAQKKVEKL---KESRAYMFQARPVDIETTSYAVLSYLAQNQ--------TSESL SIIRWLVSQRNELGGFTSTQDTVMALQALSSYAAVTY-----SDKH-TSQVTILNGKH-- ----THSFDINIRNAIVL--QSYQLSS---LNDAVSI--NANGTGVVFAQLSYSYYRDSL NDD--APFFCSQEIKEIRAGN--------------------------------------- ------------------------------------------------------------ RLQLDLCCNYTR------PGKSNMALAEIDALSGYRFDAEQVHTLTSIEDLQRVEM--EK DDTKMNVYFNPL-GGRPVCLSLYSDV-TYQVADQKPANFRLVDYYDPEEQLKMTYAAKQT RS-LQE-KC--------GEDC--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------------------WPP- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------IS------------------------------------------ ---------------------------------------PSLPPF-----DESTVT---E IY-------------------------------------------------- >NP_523506.1 Thioester-containing protein 2, isoform A [Drosophila melanogaster] MFR--------------IFLTGIILQY------------ALLV------NATGIYSVVGP GTLRSNSKYNVVVSVHKADGPSQIKVSLNGPSY-NETKQIE----LPPMSTQNVEFEVPK LATGNYNLSAEGVSG----------------VVFKNSTKLNYADKKPSVFVQTDKATYKP ADLVQFRILFLDENTRPA-KIEKPISVIIIDG-AQNRIKQLSDVKLTKGVFS--GELQLS EQPVLGTWKISVSVDGDNR---ETKSFEVDKYVLPKFEVIVDTPKAVVIADK-----VIK ATIRAKYTYGKPVK-GKATVSMER---SYGYFGDL-----NANGNKQEKTI--------D VDGKGHVEFDIIHWA----QRGQYLPP-------IKLFAVVTEELTGNKQNAT-ATVVLH QQRYSIEPYERPEHFEANKSFIYQVVVKN-VDGSPVT-NSAKNVKIGFDKSYSYFH---E PSP-----KTRINF-EAPVNENGIATFNVRLPDSDSRYYRIFASFDGSENTI-------- -----GSISKFEPTPM----SREPLKIQVN----TKKPRLGEQ-VSFDVVS-----IEDL PYFVYTIVARGNVILSDYVDVP-------------------DGQKTYT----------VK FTPTFSMVPKATIYVYYVV----NNDLQFEEKTIDFEKEFSNSIDVSAPT---------- NAKPSEEVKLRIKTDA--DSFVGLLGVDQSVLLLKS--GNDLSQDDIFNSL-NIYQTSTP WMNGYGRY----------------------PGQT-------SGLVTLTNANYPYNT---- -------------------------------------GPLVMSY-VFEGSR--------- --HPWITRPRYR--------VGIRGD----SGDRIS-------FL-----SQSLNDR--- -----------NLKEILL-------KQTPQRTTIRKEFPETWFFEN--VGE--------- ----------EEFTLTKKIPDTITSWVVTGFSLN--PTSGIALTKNPSKIRVFQPFFVST NLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMDNSDQEYEFTEAT-NEVLEKAIDEVRRV KRVTIP-ANSGKSVSFMIRPKNVG-----FTTLKITA-------------TSALAG--DA IHQKLKVEPEG-VTLFENRAVFINLKDQ-PEMSQS------------------------- ---LDADIPNEVVPQSEFIE-FSVVGDLLGPTLQ----------NLDNLVRMPYGCGEQN MVNFVPNILVLKYLEVTGRK------LPSVESKARKFLEIGYQRELTYKHDDGS--YSAF GKS-DASGSTWLTAYVMRSFHQAGTY--TDIDP-----KVITAGLDFLVSK-Q-KESGEF PEVGKLFDN---------ANQNPLALTSFVLLAFFENHEL--------IPKYQSAIKKAV RYVA----EEADKTD-DQYSLAIAAVALQLAKHPQSEKVI--AKLESVARKE--ND---- -RMWWSKATESTG----EDGRVFHWKPRSNDVEITSYVLLALLEKDP--------AEKAL PIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTG-----SGSG-TMDIEFSSAGES- ----KNTIKVNPENSLVL--QTHDLPK---STRKVDF--TAKGTGSAMVQLSYRYNLAEK EKK--PSFKVTPTVKDT------------------------------------------- ---------------------------------------------------------PNQ LLIVDVCAEYVPLEDADKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRVKRVET--KN SDSTVVVYFDSLTPGDVRCLPLEASK-AHAVAKQKPASVSLYDYYDTERKATEYYQVKSS ---LCD-IC-------EGADCG-------------------------------------- -------------------------------------EGCKKD----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------
BMGE Cleaned alignment of selected proteins >sp|P01031|CO5_HUMAN Complement C5 OS=Homo sapiens OX=9606 GN=C5 PE=1 SV=4 MGLLGILCFLTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKENKFQSAILTIQPKQLPVSYVYLEVVSKKRMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEEIDHGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYFKNFEITIKARYFYNKVVTEADVYITFGIRINGIAQVTFDSSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNDDGVASFVLNLPSGVVLEFNVKTDAPDLPEERAIAYSSLSQSYLYIDWALLVGELNIIVTPKSPYIDKITYNYLILSKGKIIHFGTREKFINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQTVSLNDSWVALAAVDSAVYGVQAKKPLERVFLGCGAGGGLNNANVFHLAGLTFLTNANADEILRPRRTLQKKIEEIAAKYKCYDGAETCEQRAARRCIKAFTECCVVAQLGRLHMKTLLPPEIRSYFPESWLWEVHLVPALPDSLTTWEIQGVGISTGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMVEGICTSLVTFTVLPLEIGLHNINFSLEILVKTLRVVPEGVKRESSGVTLDPRGIYGTSRRKEFPYRIPLDLVPKTEKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNWNIFHSKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYNSICNSLLWLVENYQLDNGSFKENQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDITALIKADSTFTLAISAYALSLGDKSIVSALKREALVKPPIYRFWKDNLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVSMDIDVSYKYKMTDKNFLGRPVEVLLNDDLIVSGLATVHVTTVVHKTSTSEEVCSFYLKIDRIVACASYKPESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGAACKCVEADCGTISAETACKPEIAYAYKVSITSVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCNAELVKGRQYLIMGKEALQIKSFRYISLTWIEYNLDEFAEDIFLNGC- >tr|E7FCV2|E7FCV2_DANRE Complement component 5 OS=Danio rerio OX=7955 GN=c5 PE=1 SV=2 MARLLLFCIFVYLITAPKVLRLDASETVVVQLFGFDQETTVHLHLKANNYQSATLRILAKDFP---VYLQTISSVKIPVTTVNGFLFIQTDKPLYTPEQEVQVRVYSLNEELRKSARTVTLTRGVKVEIIDMTDIGAKPLPPFKIPLKPIYGIWKIVATYADNFETTATAEFEVKEYVLPSISVQIEPETNYISEFDTFKLKISAKYVQGMPVKSANILLKFGY-YNGKMEVDLDIFLNAMKNTFLYVEVLLQESTGGLSQEAVLSHVKFVETPFTLSIIATPPFIKPGLPYAMRVLVKDPLGEPVKDVSVTMRKDGVAYFTCNIPANVNAEFTFETEDASW---KAESYVSVNHRYLYIDLVFEVGQVDISVVFSYRDYLSLDFSYQIISKGKVVKYDTVKRVLNIKITPDMVPSARLLVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTKPKDKLEIKESLVAFSAVDTALFNLRKKDPLKKILLGCGKGGGKNNADVFDRAGLMFITNANAKDTLRPKRSLKKKFEDKAQKY-CLSGTETCKDRANRYCRLAFEQCCVFAILSRAAIDFLMDSQVRSYFPESWLWEEHLSKTLPDSITTWELKAVGVFEGICVSDK-RIPVSQDIWVDVPLPYSMVRGEQILLKGSVYNQRSSGIKFTVTLSSAVCVFMVSFYIMALEAGTHTLTFTLESVVKKLRVVPEGIRMEEIGKRIDPNGVFGTMRKLEFKNVIPPKIVPKSSDRIITVNGEVLGDILSILNNPEGIKMLTNLPRGSAELELMSLLPVYYVYHYLDKTEWNILGKELKRKMQAGITSIMSFQLKNGEFSMWADKTPSTWVTALIIKTLSDIHEYDVLANAIHWLIKNCQNEDGSFSELNPHKLMGAG-VGVTEKSVYLTSYVMIGIKNALKIDALDRGMSLYVRAIASYAMTVADINVYENIKKKAKIDPPRVCFWQESDTVTAKSVETTVYVLLNTLTRGEEYAKPILNWLTQDQRYGGGVYSTQDTILTLEALTMYSIKANMVVDIEYKIQLTQQKPVAKPIEVTQNDDVIVTGVSFVKLKTVYYVMTESNKSCLFDTTIDRIVACAKFKPSLETESALTVMEINLPTGVTPVLEDLDEYQNGLESRISNYEVIGDKVVLQIDSIPSNFYCVGFRILEEFETGMTKASEFTVYEYQAPAFKCTKLYQKEEDHCQCMAAECCAITADDICKESVKYALKVVIDSVTYKATVQSVLKKGEDDLKTDSEVEFIKKASCSTQFEIGKQYLTMTAESMKIQAYKYKSEAWVDWVLEGFEFEYLLNGCD >NP_034536.3 complement C5 preproprotein [Mus musculus] MGLWGILCLLTYVISAPKILRVGSSENVVIQVHGYTEAFDATLSLKENKFQAALLTLQPNQVPVSHVYLEVVSKKKIPITYNNGILFIHTDKPVYTPDQSVKIRVYSLGDDLKPAKRETVLTEGSEVDIVEENDYGIISFPDFKIPSNPKYGVWTIKANYKKDFTTTGTAYFEIKEYVLPRFSVSIELERTFIGYFKNFEITVKARYFYNKVVPDAEVYAFFGLRVDGVAQISFDSSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGVKYVLSPYTLNLVATPLFVKPGIPFSIKAQVKDSLEQAVGGVPVTLMTDGVAVFVLNLPSNVVLKFEIRTDDPELPEEEAVAYSSLSQSYIYIAWPMLVGELNIMVTPKSPYIDKITYNYLILSKGKIVQYGTREKLINIPVTQNMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPSPGQTVSLDDSWVALSAVDRAVYKVQAKRAMQRVFLGCGAGGGHDNADVFHLAGLTFLTNANADEILRSKRNLRQKIEEQAAKYKCYDGAETCEERVARLCIRAFNECCTIAQLGRIHIKTLLPADIRSYFPESWLWEIHRVPTLPDSLTTWEIQGIGISNGICVADTLKAKVFKEVFLEMNIPYSVVRGEQIQLKGTVYNYMTSGTKFCVKMVEGICTSLVTFTLLPLEIGLHSINFSLDILVKTLRVVPEGVKRESAGVILDPKGIRGINRRKEFPYRIPLDLVPKTKERILSVKGLLVGEFLSTVLSKEGINILTHLPKGSAEAELMSIAPVFYVFHYLEAGNWNIFYPSLEKKIKQGVVSVMSYRNADYSYSMWKGASASTWLTAFALRVLGQVAKYNSICNSLLWLVEKCQLENGSFKENLPIKLQGTLPAEAQEKTLYLTAFSVIGIRKAVDITALDKADSTFTLAIVAYALSLGDRLIVSALRKEAFVKPPIYRYWRDTLKGTAGMVETTAYALLASLKLKDNYANPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLLDMDINVAYKYKVTEKHFLGRPVEVSLNDDLVVSGLATVYVKTVVHKISVSEEFCSFYLKIDRIIACASYKPESTSGSSHAVMDISLPTGIGANEEDLRALVEGVDQLLTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSIEGAACTCVEADCAAISADKACKPETAYAYKVRITSVKYTATLLVTYKTGEAADE-NSEVTFIKKMSCNANLVKGKQYLIMGKEVLQIKSFKYISSTWIEYNLNNFAEDLFLNSCE >NP_444179.1 complement C5 precursor [Rattus norvegicus] MGLWGLLCLLTYVISAPKIFRVGSSENVVIQAHGYTEAFDATISLKENKFQSALLTLPPKQFPVSHVYLEVVSMKKIPITYDNGFLFIHTDKPVYTPDQSVKIRVYSLSDDLKPAKRETVLTEGTEVDIVEENDYGIISFPDFKIPSNPKYGVWTIKAKYKKDFTTTGTAYFEVKEYVLPRFSVSIEPESNFIGYFKNFEITVKARYFYNKMVPDAEVYIFFGLRVNGVAQISFDSSLEDLNNKYLYIAVTVTESSGGFSEEAEIPGIKYVLSPYTLNLVATPLFLKPGIPFSIKVQVKDSLEQLVGGVPVTLMADGVASFVVNLPSEVSLKFEVKTDAPELPEEEAVTYSSLSQSYIYIGWPMLVGELNIIVTPKSPYIDKITYNYLILSKGKIVQYGTKEKLINIPVTQDMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPSPGQTVSLDDSWVALSAVDSAVYGVRAKRAMQRVFLGCGAGGGRDNVDVFHLAGLTFLTNANADEILRPKRDLHQKVEEQAAKYKCYDGAETCEQRVARHCIRAFNECCTIALLGRIQIKALLPAEIRSYFPESWLWEVHRVPALPDSLTTWEIQGIGISNGICVADTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGTMFCVKMVEGICTPLVTFSLLPLEIGLHSINFSLEILVKTLRVVPEGIKRESAGVTLDPRGVYGINRRKEFPYRIPLDLVPKTNKRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNWNIFHPSLQKKIKEGLVSVMSYRNADYSYSMWKGASSSAWLTAFALRVLGQVNKYYSICNSLLWLIEKCQLENGSFKENLPIKLQGTLPAEAQENTLYLTAFSVIGIRKAIGITALAKADSTFTLAIVAYALSLGDRSIVSALKREALVKPPIYRFWRDTLQGTAGMVETTAYALLTSLNLKESYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVDMDINVSYKYKVTEKNFLGRPVEVPLNDDLIVSGLATVYVKTVVHKTSVAEEFCSFYLKIDRIIACASYKPESASGSSHAVMDILLPTGIGANQEDLRALVEGVDQLLTDYQIKDSHVILQLNSIPSDFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMIYSTEGAACKCVEADCGAISADTACKPEIAYAYKVRITSVKYTATLLDIYKTGEAAAEKDSEITFIKKISCNANLVKGKQYLIMGKEALQIKSFKYISSTWIEYNLDEFAEDIFLNGCE >NP_001001646.1 complement C5a anaphylatoxin precursor [Sus scrofa] MGLWGILCFLTYVISAPKILHVGAAENIVVQVYGYTEAFAVTVSVKENKFQSAFLTIQPKQLLVSHVYLDIVSKKKIPVTYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDELKPAKRETVLTQGSEVEVLEENDYGIISFPDFKIPSNPKYGVWTIQAKYREDFSTTGTAYFEIKEYVLPHFSVSIEPENNFIGYFNDFEITVKARYFYNKVVSEADVYMFFGIRINGIAKVTFNSSLEDLNNKYLYIGVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSIKVQVKDSLDLLVGGVPVILSRDGVASFVVNLPAGVVLEFNIRTEDPDLSDERAIAYSSLSQSYLYIEWPVLVGELNVVVTPKSPYIDKITYNYLILSRGKIVHFGTREKLINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQHVSLNDSWVALSAVDKAIYGVQAKKPLERVFLGCGAGGGRNNADVFHLAGLTFLTNANTDDILRPKRMLQKKIEEEAAKYKCYDGAETCEERAARKCVKAFKDCCYIAQLGRLHIKTLLAPEIRSYFPESWLWEVHHVPVLPDSLTTWEIQGIGISSGICVTDTLNAKVLKDVFLEMSIPYSVVRGEQIQLKGTVYNYGTSGVLFCVKMVEGICSSLVTFDVLPLEIGLHNINFSLEILVKTLRVVPEGVKRESAGITLDPRGIYGATRRKEFPYRVPLDLVPKTKKRIVSVKGLLIGEVMSAVLSQEGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGNWNIFSSNLQKKLREGVVSVMSFRNADHSYSMWKSGSASTWLTAFALRVLGQASKYNSICNSILWLVEKCQLGNGSFKENQPIKLQGTLPIEAQENTLYLTAFAVIGIRKAFDLMALTKADSTFALAIAAYALSLGDKSIVSALKKEALVKPPIYRFWKDDLQGTARMVETTAYALLTSLNLKDNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLINMDVKVSYKYKITEKNFIGRPVEVPLNDDLVVSGLATVHVKTVVHKTSTSEEVCSFDLKIERIVACASYKPESSSGSSHAVMDISLPTGVNANAEDLRALVEGVDQLLTDYEIKDGHVICQLNSIPSNFLCVRFRIVELFQVGFLSPATFTVYEYHRPDKQCTMFYSMEGVTCKCVEADRGTISVNTACKPEIAYVYKVKIIAVKYTASLLDVYKAGEAVAEKGSEITFIKKTTCNANLEKGKQYLIMGKEALQIKNFKYISSTWIEYNLDEFTEDIFLNNCE >XP_415405.5 complement C5 isoform X1 [Gallus gallus] MAILMYFFVLTYVLTAPKVFRVGTSEKVVVQAFGYEKEFAVNLALRDNNFQSVTVTLQPTDLAVKYVYLEAVSPKKVPVSYENGFLFVHTDKPIYTPDQSVKVRVYSLNEELQPARRETVLTDGVKVDIIEENDFGIVSFPDFKIPPNPKYGIWKIEAKYKKNFITSAVAKFEVKEYAMPSFSIVIEPENNFISSFENFRIAVKASYFYNKRLAKADVFLRFGI-TNGVAEINFNSSLEELDGSYLYIAASVVESMGGLSGEVEFSEVKYAVSPYTLSLIATPLFIKPGLPFFIKVQVKDTVDRFVGNIPLVITNDGTALFVVNVPTDSLLEFQVKTADPHLSDEEARVYSSLSQSYLYIDWILSVGDISINIYPRSRYIHNIHYSYLITSKGKIVSFGTQKRILSFQITQEMVPSARLIVYYIV-GEEPAELVADSVWLNVEQKCGSSLDIKLLSKPAEIVSLNDSFVALSSIDKAIYGVTGKRAMEKIMLGCGAGGGQNNVDVFRMAGLTFLTNANADEVIRTKRSFEEQVLKEASKYKCMHGVETCSDRARRKCVSAFRHCCEFAILARKQFEAFLEAEVRSYFPESWLWEVHQVSTLPDSLTTWEVQGVGISKGICVAAPLEVQVVKDIFLSIYVPYSVVRGEQIELKGSVYNHRASAIKFCVKIGDGICSSPIVFRILPLELGLHTINFTLETVVKTLRVMPEGIKKELAGFTLDPQGVYGSKRRQEFRYKIPLNLVPKTKDRSVSVKGHLMGEVIATILSPEGLSILTNLPKGSAEAELMTIAPVFYVFHYLEASNWHILGPAMRRKMKEGIVSVLSFRNSDFSYSMWKNGKASTWLTAFALRILGQVNQYISVCNSLLWLIDNCQMPDGSFSEFQPVKLQGTLPREAKEKSLYLTAFSIIGIEKSIKIDAKNKAGSPFTMAIISYALALVDLSLFSALKREASVIPPIYRFWKDDFKVTAQMVETTAYALLTALLRGDNYANPIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVDMGIKVAYRFKLTEDNFVGRSVTVPLDDDIYVTGIATVNVRTVYNVMGTSEESCNFELKIVRLEACAKYRPEPQSGSAHVVMDISLVSGLEANSEDLSTLASGVDQLIADYEIKDGHVILQIDSVPARFLCVGFRISQLFHVGMLNPGTFSVYEYHAPDKRCTVFYNPEGDECKCMEAECSSITADVACQNDIAYVYKVNILSVKYSATILDLYKRGQAFAQKNNEVTFVKKKTCNVELSPGMQYLIMGKEALKINSFRFQSSTWIEWRMEDFVEDLIISGC- >XP_016817059.1 complement C5 isoform X1 [Pan troglodytes] AGSTGCGAF-RYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKENKFQSAILTIQPKQLPVSYVYLEVVSKKKMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEEIDHGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYFKNFEITIKARYFYNKVVTEADVYITFGIRINGIAQVTFDSSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNDDGVASFVLNLPSGVVLEFNVKTDAPDLPEERAIAYSSLSQSYLYIDWALLVGELNIIVTPKSPYIDKITYNYLILSKGKIIHFGTREKFINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQTVSLNDSWVALAAVDSAVYGVQAKKPLERVFLGCGAGGGLNNANVFHLAGLTFLTNANADEILRPRRMLQKKIGEIAAKYKCYDGAETCEQRAARRCVKAFTECCVVAQLGRLHMKTLLPPEIRSYFPESWLWEVHLVPALPDSLTTWEIQGVAISNGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMVEGICTSLVTFTVLPLGIGLHNINFSLEILVKTLRVVPEGVKRESSGVTLDPRGIYGTSRRKEFPYRIPLDLVPKTEKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNWNIFHSKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYNSICNSLLWLVENYQLDNGSFKENQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDITALIKADSTFTLAISAYALSLGDKSIVSALKREALVKPPIYRFWKDNLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVSMDIDVSYKYKMTDKNFLGRPVEVLLNDDLIVSGLATVHVTTVVHKTSTSEEVCSFYLKIDRIVACASYKPESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGATCKCVEADCGTISTETACKPEIAYAYKVSITSVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCNAELVKGRQYLIMGKEALQIKSFRYISLTWIEYNLDEFAEDIFLNGC- >XP_038512006.1 complement C5 isoform X1 [Canis lupus familiaris] MGLWGILWFLTYVISAPKVFRVGASENVVIQVYGYTEEFDATISIKENKFQNVVLTIQPKQLSVSHVYLEVVSRKKVPITYDNGFLFIHTDKPIYTPQQSVKVRVYSLNDDLKPAKRETVLTEGSEVDIVEENDYGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTGTTQFEVKEYVMPHFTISIEPEKSFIGYFNNFEITIKARYFYNKVVTEAEVYISFGIRINGVAQVTFNSSLEDLNDKYLYIGVTVIESTGGFSEEAEIPGIKYILSPYKLNLVATPLFLKPGIPYSIKVQVKDVLDQLVGEVPVTLSSDGVASFVVNLPSGAVLEFNVKTADPDLPEEQAIAYSSLSQSYLYIDWPFLVGELNIIVTPRSPYIDNITYNYLVLSKGKIVHFGKAEKLVNIPVTPDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPYPGQSVSLNSSWVALSAVDSAIYGVQAKKPMQRVFLGCGAGGGRNNAEVFYLAGLTFLTNANADEILRPRRMLRKKIEEEAAKYKCYDGAETCEQRAARWCAKAFRACCDIAQLGRLQIKHLLPPEIRSYFPESWLWEVHHVSGLPDSLTTWEIQGVGISSGICVADTLKVQVFKDIFLEMNIPYSVVRGEQIELKGTVYNYRRFGIRFCVQMAEGICTALVTFSVLPLEIGLHNINFSLEILVKTLRVVPEGIKKESAGVTLDPRGIYGVSRRKEFPYRIPLDLVPKTEKRIVSVKGMLMGEVMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVFHYLEAGSWNIFSPSLKNQLKQGMVSITSYRNADYSYSMWKGGDASTWLTAFALRVLGQVQKYNSICNTLLWLTENCQLENGSFKENQPVKLQGTLPTEAHEHSLYLTAFAVIGIRKAFDLAALTRADSTFTLAIAAYALSLGDRSIVSGLKRKALVKPVIYRFWKDDHQGTARTVETTAYALLTCLSLGDAYVNPVVRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLINMDVKISYKYKMTEKNFLGRPIEVPLNDDLVVNGLATVHVTTVVQKTSTSEEVCSFDLKIDRIIACASYKPESSSGSSHAVMDISLPTGVSANIEDLRALVEGVDQLLTDYQIKDGHVILQLDSIPSEFLCVRFRIFELFQVGFLSPATFTVYEYHRPDKQCTMFYSPEGVTCKCVEADCGTISADTACKPDIAYAYKVHITSIKYTATLLDVYKAGEAAAQKDSEITFIKKATCNAELEKGRHYLIMGKEALQIKSFKYISSTWIEYNLDEFAEDIFLNGCE >NP_001160088.1 complement C5a anaphylatoxin precursor [Bos taurus] MGLWGILCFLTYVISAPKVFHVGAYENVVIQAYGYTEEFDATVSIKENKFQSATLTIQPKQLSVSHVYLEVTSKKKMPVTYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEENDYGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPKSNFIGYFTNFEITIRARYFYNKVVNEADVYITFGIRINGMAQVTFNSSLEDLNNKYLYIGVTIIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEVVLEFNIKTEDLDLPEERAVAYSSLSQSYLYIDWHLLVGALNIVVTPRSPYIDKITYNFLILSKGKIVHFGTRDKLINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSPSPGQRVSLNDSWVALTAVDSAIYGVQAKRPLERVFLGCGAGGGRDNAEVFYLAGLTFLTNANADEILRPKRMLKKKIEEEAAKYRCYDGAETCEQRAARICIKAFKSCCAIAQLGRLHIKSLLPPEIRSYFPESWLWEVHRVPVLPDSLTTWEIQGVGISSGICVADTLKAKVFKSVFLEMNIPYSVVRGEQVQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLEVGLHNLSFSLEILVKTLRVVPEGVKRESAGVTLDPQGVYGISRRKEFPYRIPLNMVPKTKKRTVSIKGLLIGEIMSAVLSQEGIDSLTRLPKGNAEAELMSVVPVFYVYHYLEAGHWDIFSTNLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYNSICNSLLWLLEKCQLENGSFKENQPVKLQGTLPVEAREKTLYLTAFAVIGIRKAFDITAVSKADSAFTLAIAAYALSLGDKAIVSALKRKAFVKPPIYRFWKDDLQGTARMVETTAYALLTNLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDVKVSYKYKMSDKYFLGRPIEVPLNDDLVVSGLATVHVKTVVHKISTSEEVCSFHLKIERIVACASYKLESSSGSSHAVMDISLPTGVNANPEDLKALVEQVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGVTCKCIEADCGTISAATACKPEIAYAYKVEIVAVKYTATLLDIYKAGEAAAERDAEITFIKKTSCNANLEKRKQYLIMGKEALQIKRFKYVSSTWIEYNLDEFTEDIFLNGCE >XP_024108622.1 complement C5 [Pongo abelii] AGPTGCGAF-RYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKENKFQSAILTIQPKQLPVSYVYLEVVSKKKMPVTYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEEIDHGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTTYFEVKEYVLPHFSVSIEPECNFIGYFKNFEITIKARYFYNKVVTEADVYITFGIRINGIAQITFDSSLEDVNNKYLYVAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYSIKVQVKDSLDQLVGGVPVTLNDDGVASFVLNLPSGVVLEFNVKTDAPDLPEERAIAYSSLSQSYLYIDWALLVGELNIIVTPKSPYIDKITYNYLILSKGKIIHFGTREKFINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQTVSLNDSWVALAAVDSAVYGVQAKKPLERVFLGCGAGGGLNNANVFHLAGLTFLTNANADEILRPRRTLQKKIEEIAAKYKCYDGAETCEQRAARRCVKAFTECCVVAQLGRLHMKTLLPPEIRSYFPESWLWEVHLVPALPDSLTTWEIQGVGISSGICVADTVKAKVFKDVFVEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMVEGICTSLVTFTVLPLEIGLHNISFSLEILVKTLRVVPEGVKRESSGVTLDPRGIYGTSRRKEFPYRIPLDLVPKTEKRILSVKGLLVGEILSAVLSQEGINILTHLPRGSAEAELMSIVPVFYVFHYLETGNWNIFHSKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYNSICNSLLWLVENYQLDNGSFKENQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDITALIKADSTFTLAISAYALSLGDKSIVSALKREALVKPPIYRFWKDDLQGTAHMVETTAYALLASLNLKDNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDIDVSYKYKMTDKNFLGRPVEVLLNDDLIVSGLATVHVTTVVHKTSTSEEVCSFYLKIDRIVACASYKPESSSGSSHAVMDISLPTGIGANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGAVCKCVEADCGAISAETACKPEIAYAYKVSITSVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCNAELVKGRQYLIMGKEALQIKSFRYISLTWIEYNLDEFAEDIFLNGC- >XP_003207914.2 complement C5 [Meleagris gallopavo] MAILIYFFVLTYVLTAPKVFRVGTTEKVVVQAFGYENEFAVSLALRENNFQSVTVTLQPTDLAVKYVYLEAVSPKKIPVSYENGFLFIHTDKPIYTPDQSVKVRVYSLNEELQPARRETVLTDGVKVDIIQENDFGIVSFPDFKIPPNPKYGIWKIEAKYKKNFITSAVAKFEVKEYAMPSFSIVIEPEHNFISSFENFRIAVKASYFYNKRLAKADVFLRFGI-TNGVAEINFNSSLEELDGSFLYIAASVAESMGGLSGEVEFSGVKYAVSPYTLSLIATPLFIKPGLPFFIKVQVKDTVDHFVGNIPLIITNDGTALFVVNIPPDSLLEFQVKTADPHLSDEEARVYSSLSQSYLYIDWVLNVGDISINVYPRSRYIHNIHYSYLITSKGKIVSFGTQKRILSFQITQEMVPSARLIVYYIV-GEEPAELVADSVWLNVEQKCGSSLDIKLLSKPAEVVSLNDSYVALSSVDKAIYGVTGKGAMKKIMLGCGAGGGQNNVDVFRMAGLTFLTNANADEVIRTKRSFEERVLKEASKYKCMHGVETCSDRARRKCISAFINCCEFAILARKQFEALLETEVRSYFPESWLWEVHQVSTLPDSLTTWEVQGVGISRGICVAAPLEVQVVKDIFLSIYVPYSVVRGEQIELKGSVYNHRASAIKFCVKIGDGICSSPIMFRILPLELGLHTINFTLETVVKTLRVKPEGIKKELAGFTLDPQGVYGSKRRQEFRYKIPLNLVPKTKDRSVSVKGHLMGEVIATVLSPEGLSILTNLPKGSAEAELMSVAPVFYVFHYLEASNWHVLGPQMRRKMKEGIVSILSFRNSDFSYSMWKNGQASTWLTAFALRILGQVNQYISVCNTLLWFIENCQMPDGSFSEFQPVKLQGTLPREAKEKSLYLTAFSVIGIEKSIKMDAKNKAGSPFTMAIISYALALVDLSLFSALKREASVIPPIYRFWKDGFKVTAQMVETTAYALLTALLRGDSYANPIIKWLSEEQRYGGGFYSTQDTVNALEALTEYSLLVDMGVKVAYKFKLTEDNFVGRAVTVPLDDDIYVTGIATINVRTVYNVMGTSEESCNFELKIAHLEACAKYRPEPQSGSAHAVMDISLVSGLVANTEDLSTLASGVDQLIADYEIKDGHVILQIDSVPARFLCVGFRISQLFHVGMLNPGTFTVYEYHAPDKRCAVFYNPEGDECKCMEAECSSITAGVACQNDIAYVYKVNILSVKYSATILDLYKRGQAFAQKNNEITFVKKKTCDVELSPGMQYLIMGKEALKINSFRFQSSTWIEWRMEDFVEDLIISGC- >XP_024785786.2 complement C5 isoform X1 [Pan paniscus] AGSTGCGAF-RYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKENKFQSAILTIQPKQLPVSYVYLEVVSKKKMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEEIDHGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYFKNFEITIKARYFYNKVVTEADVYITFGIRINGIAQVTFDSSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLVGGVPVTLNDDGVASFVLNLPSGVVLEFNVKTDAPDLPEERAIAYSSLSQSYLYIDWALLVGELNIIVTPKSPYIDKITYNYLILSKGKIIHFGTREKFINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQTVSLNDSWVALAAVDSAVYGVQAKKPLERVFLGCGAGGGLNNANVFHLAGLTFLTNANADEILRPRRMLQKKIGEIAAKYKCYDGAETCEQRAARRCVKAFTECCVVAQLGRLHMKTLLPPEIRSYFPESWLWEVHLVPALPDSLTTWEIQGVAISNGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMVEGICTSLVTFTVLPLGIGLHNINFSLEILVKTLRVVPEGVKRESSGVTLDPRGIYGTSRRKEFPYRIPLDLVPKTEKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNWNIFHSKLKKKLKEGMLSIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYNSICNSLLWLVENYQLDNGSFKENQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDITALIKADSTFTLAISAYALSLGDKSIVSALKREALVKPPIYRFWKDNLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVSMDIDVSYKYKMTDKNFLGRPVEVLLNDDLIVSGLATVHVTTVVHKTSTSEEVCSFYLKIDRIVACASYKPESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGATCKCVEADCGTISTETACKPEIAYAYKVSITSVKYKATLLDIYKTGEAVAEKDSEITFIKKVTCNAELVKGRQYLIMGKEALQIKSFRYISLTWIEYNLDEFAEDIFLNGC- >XP_023098426.1 complement C5 [Felis catus] MGLWGILVFLTYVISAPKIFRVGASENIVIQVYGYTEAFDATISLKENKFQSAVLTVQPKQLSVSHVYLEVVSKKKVPITYDNGFLFIHTDKPVYTPQQSVKVRVYSLNDDLKPAKRETVLTEGSEVDIMEENDYGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTATAYFEIKEYVLPHFSVSIEPENSFIGYFNDFEITIKARYFYNKVVTEAEVYITFGIRINGIAQVTFNSSLEDLNDKYLYIGVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFMKPGIPYSIKVQVKNSFDQLVGGVPVTLSSDGVASFMVNLPSGAMLEFNVKTDDPDLPEEQAIAYSSLSQSYLYIDWPLLVGELNVIVTPRSPYINKITYNYLILSKGKIVHFGTREKLINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPSQHVSLNNSWVALSAVDSAIYGVQAKKPLERVFLGCGAGGGRNNADVFHLAGLLFLTNANVDEILRPKRMLQKKIQEEVAKYKCYDGAEDCEQRAARRCVRIFKECCLIAQLGRLHIKTLLPPEIRSYFPESWLWEVHHVPVLPDSLTTWEIQGVGISSGICVADTLKAQVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRMSGMRFCVKMVEGICTSLVTFSVLPLEIGLHNINFSLEILVKTLRVVPEGIKKESAGVTLDPRGIYGVSRRKEFPYRIPLDLVPKTKKRIVSVKGLLIGEVMSTVLSQEGIDILTHLPKGNAEAELMSIVPVFYVFHYLEAGKWNIFSTNLRKKLKEGMVSIMSYRNADSSYSMWKGGSASTWLTAFALRVLGQLNKYNSICNTLLWLVENCQLENGSFKENQPIKLQGTLPVEARENTLYLTAFAVIGIRKAFDITAITKADSTFTLAIAAYALSLGDKSIVSALKKKALVKPVIYRFWKDDLQSTAHVVETTAYALLTSLSLKDNYVNPIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLINMDINVSYKYKMTETNFLGRPIEVPLNDDLVVNGVATVHVTTVVQKTSTSDEICSFHLKIERIVACASYKPESSSGSSHAVMDISLPTGIGANQEDLKALVERVDQLLADYQIKDGHIILQLNSIPSEFLCVRFRIFELFQVGFLNPATFTVYEYHRPDKQCTMFYNPEGVTCKCIEADCGTISADTACKPDIAYAYKVRITSVKYTATLLDIYKAGEAVAQKDSDVTFIKKVTCNADLEKGRQYLIMGKEALQIKSFKYLSSTWIEYNLDEFAEDIFLNGCE >XP_030870703.1 complement C5 isoform X1 [Gorilla gorilla gorilla] MGLLGILCFLTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKENKFQSAILTIQPKQLPVSYVYLEVVSKKKMPITYDNGFLFIHTDKPVYTPDQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEEIDHGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEVKEYVLPHFSVSIEPEYNFIGYFKNFEITIKARYFYNKVVTEADVYITFGIRINGIAQVTFDSSLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSLDQLAGGVPVTLNDDGVASFVLNLPSGVVLEFNVKTDAPDLPEERAIAYSSLSQSYLYIDWALLVGELNIIVTPKSPYIDKITYNYLILSKGKIIHFGTREKFINIPVTQNMVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQTVSLNDSWVALAAVDSAVYGVQAKKPLERVFLGCGAGGGLNNANVFHLAGLTFLTNANADEILRPRRTLQKAIEEIAAKYKCYDGAETCEQRAARRCVKAFTECCVVAQLGRLHMKTLLPPEIRSYFPESWLWEVHLVPALPDSLTTWEIQGVGISSGICVADTVKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMVEGICTSLVTFTVLPLEIGLHNINFSLEILVKTLRVVPEGVKRESSGVTLDPRGIYGTSRRKEFPYRIPLDLVPKTEKRILSVKGLLVGEILSAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNWNIFHSKLKKKLKEGMLNIMSYRNADYSYSVWKGGSASTWLTAFALRVLGQVNKYNSICNSLLWLVENYQLDNGSFKENQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDITALIKADSTFTLAISAYALSLGDKSIVSALKREALVKPPIYRFWKDNLQGTARMVETTAYALLTSLNLKDNYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDIDVSYKYKMTHKNFLGRPVEVLLNDDLIVSGLATVHVTTVVHKTSTSEEVCSFYLKIDRIVACASYKPESSSGSSHAVMDISLPTGISANEEDLKALVEGVDQLFTDYQIKDGHVILQLNSIPSDFLCVRFRIFELFEVGFLSPATFTVYEYHRPDKQCTMFYSAEGATCKCVEADCGTISTETACKPEIAYAYKVSITSVKYKATLLDIYKTGEAVPEKDSEITFIKKVTCNAELVKGRQYLIMGKEALQIKSFRYISLTWIEYNLDEFAEDIFLNGCQ >XP_011478017.1 complement C5 [Oryzias latipes] KVCVLLLCVCSYLVTAPSSFRVDAVETVFVQLFGYTREVTVFVFLKNNKFQLANVQLYPNVLTIQKVVLHVQSDVFVPISRSNGFMFIQTDKPLYTPHQNVKVRAFSMNQELRPANRSVFLTDRVTVDVVEMVDIGIPTMKRFKIPIKPKLGIWTIEASYSDDFTTTAVTDFEVKEYVLPSIDINVQPSLNFISDFNSFDFKISARYVHGAPVADGEVFLRYGYVSSGEVEVNLNMELSSLVGKYLYMAVLVQEETGGISQEAEFASVKFLKSPYHLSLISTPPFIKPGLPYNIKLLVKDHLDKPVNRVSVELVSDGFIYLICNPWKTSKAVLKFQTA--GLAEAESVAYHSPNERYLYINTSLVVGRTQIQVQTASPSYLNIQLNYLVLSKGKVVFHKSVDFVLNFMVTPSMVPSIRLLVFYILHGEGTSELVADSVWIDVKHKCINGLETSVTVKPKENLNIDPGLVALSAVDSAVYSIRYKDPISMVLLGCGGGGGKDNADVFRLAGLTFLTNANAQAAVRSKRASDEAKEAKAQSY-CVKGMVTCRQYALQRCREAFRECCEFYILAR-HIGVNFD-QVRSYFPESWLWEVQPISKLPDSLTTWEIQAVGMFGGMCVADTAKVSVNLPLSVDIPLPYQVVRGEQVVLQGSVYNQQDKSIKYCVTLGPAVCLLKVVFTLLGLEPGMHTLTFTLDILEKNLRVVPEGVRRDVSGGSLDPQGVYGSKLKVVLHNQMPANVVPNSAQRMLAINGELPGEVVTVLTKPEGIKTLIDLPLGLAIAKLDTLFLLTQVYLYLETTSWDLFGADLKQKIQDGLIDLSSIRNGDSSYSTSIKAEPSTWVTAMVVKVLALADSVQSLSESVTWLISKTQQADGSFSELKPNRAMVEG-ADPIEKSVYVTSIVLIALQRASEISSRRSAASVYVRAVATYALTLHDPELISSLESVARQKPVELRYWQEADVSSGQTVETTSYVLLTMLLKGRPYANPILSWLTQDQYYGDGFFSSTDMVLTLEALTEYKKLIDQQINIRYNVALNRRQPVVAPIEISLTDDITVKGVSNVKLKTVFYQTTASLQRCNFELNIEHLAACVKYKPEVSTASSLTVLKIQLPTGVEPYLEDLRQFMDPDNPIISHYELQGSTVVILMDTVPSIFLCVGFRVRTRFKVVGASDCLFTVSERQDRGSLCTKEFSPLGEQCQCMTAACASLTSVELCQPHVKYGLIVAVRSMIYSASVVEVLKNTEEALNPKSEVELVKKATCSINLQDNKQYLVFGSRGSEVQHFKYRSEALVELQMEDFSVYFMLNECI >XP_005512961.1 complement C5 isoform X1 [Columba livia] MTILMCFFVFTYVLTAPKIFRAGASEKVVVQAFGFEKEFPVNIAIKANKFQAATLTLQPADLPVNYVYLEAVSPKKIPVSYENGFLFIHTDKPIYTPDQSVKVRVYSLNEELQPARRETVLTEGVKVDIVEEEDFGIVSFPDFKIPPNPKYGIWKIEAKYKKNFITSAVAKFEVKEYAMPSFSITIEPESNFISSFESFRIVVKASYFYNKRLPSADVFLRFGI-ENGVAAINFNSSLEELDGSYLYIVASVLESEGGLSGEAEFAGVRFAVSPYKLSLIATPLFVKPGLPFFIKVQVKDTGDHFVGNVPITISNDGTALFVVNIPSDCILEFQVKTADPHLSDEEAKAYSSLSQSYLYIDWILEVGDVNIKVYPHSRYIHKIHYSYLITSKGKIVSFGTQKRMLTFQITQEMVPSARLIVYYIVMGEEAAELVADSIWLNVEQKCGNSLDIRLQSKPAEAISLDSSFVALSSIDKAVYGVTGKRAMEKIMLGCGAGGGRNNIDVFRMAGLTFLTNANADEVLRTKRSFKEKILKEASKYTCMAGVETCSDRARRKCISAFTDCCEFAILARMHFESVLEAEVRSYFPESWLWEVHQVSTLPDSLTTWEVQGVGISKGICVAAPLEVPVVKDIFLSVYVPYSVVRGEQIELKGSVYNHRDSPIKFCVKIGNGICAFPVTFRILPLELGLHTINFTLEIVVKTLRVMPEGVKKELAGFTLDPQGVYGSKRRQEFRYKIPLNLVPKTKDRSVSVKGHLMGEAIATVLSPSGLGVLTALPKGSAEAELVSIAPVFYVFHYLEESNWHLLGPRLRRKMKEGIVSILSFRNSDFSYSMWKNGQASTWLTAFALRILGQVNQYISVCNSLLWLIENCQMPDGSFSEFQPVKLQGTLPREAKEKSLYLTAFSLIGIEKSIQIDAKNKAGSPFTMAITSYALALMDLAAFSALKKEASVIPPIYRFWKNTFKVTAQMVETTAYALLTTLLRGDNYAKPIIKWLSEEQRYGGGFYSTQDTINALEALTEYSLLVDMSVKVAYKFKLTEDNFVGRTLTVPLGDDIYVTGIATVNVKTVYNTIGTSEESCNFELKIVRLEACAKYRPEPQSGSAHAVMDIGLVSGLEANTEDLSTLASGVDQLIADYEIKDGHVILQIDSVPANFLCVEFRISELFQVGMLNPATFTVYEYHAPDKRCTMFYNPEGDECKCMEAECSSLTADAACQSDIAYVYKVNILSVKYSATLLDLYKRGQAFAQKNNEVTFVKKKTCDVELSPGEQYLIMGKEALKISNFKFQSSTWIEWTMEDFTEDLMISGC- >XP_013821764.2 PREDICTED: complement C5 [Capra hircus] MGLRGILCFLTYVISAPKVFHVGASENVVIQVYGYTEEFDATVSIRENKFQSATLTIQPKQLSVSHVYLEVISKKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMIEENDYGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTGTAYFEVKEYVLPHFSISIEPESNFIGYFTNFEITIRARYFYNKVVNEADVYISFGIRINGIAQVTFNSSLEDLNDKYLYIGVTITESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSIKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEVVLEFNIKTEDLDLPEERAVAYSSLSQSYLYIDWHLLVGELSIVVTPRSPYIDKITYNYLILSKGKIVHYGTRDKLINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSPSPGQRVSLTDSWVALTAVDSAIYGVQAKRPLQRVFLGCGAGGGRDNADVFYLAGLTFLTNANADEILRPKRMLKKKIEEEAAKYRCYDGAENCEQRAARICIKAFKECCAIAQLGRLHVKSLLPPEIRSYFPESWLWEVHHVPVLPDSLTTWEVQGVGISSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLEIGLHNLSFSLEILVKTLRVVPEGVKRESAGVTLDPQGIYGISRRKEFPYRIPLNMVPKTKKRTVSIKGLLIGEVMSAVLSEEGIDSLTHLPKGNAEAELMSAVPVFYVYHYLEAGHWDIFSTNLKTKLKEGMASIMSFRNADYSYSMWKGGGASTWLTAFALRVLGQISKYNSICNSLLWLLEKCQLENGSFKENQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDITAVSKADSAFTLAIAAYALSLGDKSIVSALKKKAFVKPPIYRFWKDDLEGTARMVETTAYALLTSLSLKDNYVSPIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLGNMDVKVSYKYKMSEKYFLGRPIEVPLSDDLVVSGLATVHVKTVVHKISTSEEVCSFHLKIERIVACASYKFESSSGSSHAVMDISLPTGVNANPEDLKALVEQVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGATCKCIEADCGTISAARACKPDIAYAYKVEIIAVKYTATLLDVYKAGEAAAERDAEITFIKKTTCNANLEKRKQYLIMGKEALQIKRIKYVSSTWIEHNLDAFTEDIFLNGCE >XP_014382164.1 complement C5 [Alligator sinensis] MNIFSFFCILTYVVSAPKILRVGASEKVVIQAFGYKNEFSVNIAIKANKFQSVTLMIQPKDLPV-HVYLEASSVKKMLVTYDNGYLFIQTDKPIYTPDQSVKVRVYSLNQELKPAQRETVLTEGVKVDIIEENDFGIVSFPDFKIPSNPKYGTWKIEAKYKKSFTTTAFTKFEVKEYAMPSFSVSIEPEYNFISFFEKFKITIQASYFYNKVVAWADVFVRFGI-TNGVAEINFNSSLEELNGAYLYIAATVLESDGGHSEEAEFFGVKFVLSPYKLNLVATPLFVKPGLPFSIKVQVKDTLSQPVGNLPVTLTTDGTALFIVNIPSDSTLEFQVKTADPSLSEEEATAYSSLSKSYLYIDWMLHVGDININVHPSSHYIHKIYYSYLILSKGKIISFGTQARIVSFQLTQDMVPSARLLVYYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSSKPGKNIPFYSSFVTLSSMDKAIYGVARKRSMERVMLGCGAGGGQNNVNVFRLAGLTFLTNANADAIVRSKRFFEEEIKKRASRYVCMDGVETCEERTKRKCLYAFKDCCEYAMLARKQFEAFLDPEVRSYFPESWLWEVHQVPTLPDSLTTWEIQGVSISKGICVADPLEVQVFKDVFLSMHIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVGEGICLFSVTIRLLPLELGLHTINFTLEILVKTLRVVPEGIKRELAGFTLDPKGVYGSRTRQEFRHRVPFNMVPKTKDRTVSVKGQLMGEVISAVLKPEGVGFLTNLPKGSAEAELMSIVPVFYVYHYLEKTSWDLLGTKMKRKMKEGIVSILSFRNRDFSYSMWKDGKPSTWLTAFALRIFGQVSEYISVCNSLVWLTDCCQMSDGSFKELQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHMDAKLKAESTFTLAITCYALALMDLLAFGNLKKEAFAKPPIYRFWKDTLKGTAQMVETTAYALLTTLKGGDMYANPIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILADMNVKVAYKYKLTEQNFIGRPVTVPLDEDIYVTGLATVNVRTVYHTISTSDEICNFELTVTRLEACAKYKPEPQSESAHAVMDISLPSGVEADEEDLYILATGVDQLIRSYEIKDGHIIIQIDSVPAKFLCVAFRINEIFHVGMLSPATFTVYEYHAPDKKCTIFYNPEGNECKCMEAECSSVSADVACQQDIAYVYKVKILSIKYTATLLDVYKRGGALVKKNDETTFVKKNTCDVVLNPGEQYLIMGKEALRIVSFKYQSKTWIEWTMEGFVEDLLISGC- >XP_014459225.1 PREDICTED: complement C5 isoform X1 [Alligator mississippiensis] MNIFSFFCILTYVVSAPKILHVGASEKVVIQAFGYKNEFSVNIAIKANKFQSVTLMIQPKDLPV-HVYLEASSVKKMPVTYDNGYLFIQTDKPIYTPDQSVKVRVYSLNQELKPAQRETVLTEGVKVDIIEENDFGIVSFPDFKIPSNPKYGTWKIEAKYKKSFTTTAFTKFEVKEYAMPSFSVSIEPEYNFISFFEKFKITIQASYFYNKVVAWADVFVRFGI-TNGVAEINFNSSLEELNGAYLYIAATVLESDGGHSEEAEFFGVKFVLSPYKLNLVATPLFVKPGLPFSIKVQVKDTLSQPVGNLPVTLTTDGTALFIVNIPSDSTLEFQVKTADPSLSEEEATAYSSLSKSYLYIDWMLHVGDININVHPSSHYIHKIYYSYLILSKGKIISFGTQARIVSFQLTQDMVPSARLLVYYIVTGENTAELVADSVWLNVEQKCGNSLEIKLSSKPGKNIPFYSSFVTLSSMDKAIYGVARKRSMERVMLGCGAGGGQNNVNVFRLAGLTFLTNANADAIVRSKRFFKEEIKKRASRYVCMDGVETCAERTKRKCLYAFQDCCEYAMLARKQFEAFLDPEVRSYFPESWLWEVHQVPTLPDSLTTWEIQGVSISKGICVADPLEVQVFKDVFLSMHIPYSVVRGEQIKLKGSVYNYGTSTLKFCVKVGEGICLFSVTIRLLPLELGLHTINFTLEILVKTLRVVPEGIKKELAGFTLDPKGVYGSRTRQEFRHRVPFNMVPKTKDRTVSVKGQLMGEVISAVLKPEGVGFLTNLPKGSAEAELMSIVPVFYVYRYLEETSWDLLGTKMKRKMKEGIVSILSFRNPDFSYSMWKDGKPSTWLTAFALRIFGQVSEYISVCNSLVWLTDRCQMSDGSFKELQAVKLQGTLPKEAKEKALYLTAFTVIGIEKSIHMDAKLKAESTFTLAITCYALALMDLLAFGNLKKEAFAKQPIYRFWKDTLKGTAQMVETTAYALLTTLKGGDMYANPIIRWLSEEQRFGGGFYSTQDTINALEALTEYSILADMNVKVAYKYKLTEQNFIGRPVTVPLDEDIYVTGLATVNVRTVYHTISTSDEICNFELTVTRLEACAKYKPEPQSESAHAVMDISLPSGVEADEEDLYILATGVDQLIRSYEIKDGHIIIQIDSVPAKFLCVAFRINEIFHVGMLSPATFTVYEYHAPDKKCTIFYNPEGNECKCMEAECSSVSADVACQQDIAYVYKVKILSIKYTATLLDVYKRGGTLVKKNDEITFVKKNTCDVVLNPGEQYLIMGKEALRIVSFKYQSKTWIEWTMEGFVEDLLISGC- >XP_008271599.1 PREDICTED: complement C5 isoform X1 [Oryctolagus cuniculus] MGLWGIFCFLTYVISAPKVLRVGASENIVIQVYGYTEAFDSTISIKENKFQSATLTIQPKQLSPSHVYLEVVSKKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLVEGSEVDMVEENDYGIISFPDFKIPSNPKYGVWTIKAKYKEDFSTTGTTYFEVKEYVLPHFSVSIEPESNFIGYFKNFEITIKARYFYNKVVSDAEVFIFFGIRINGVAQVTFDSSLEDLNNKYLYIAVTVIESTGGFSEEAEVPGIKYVLSPYKLNLVATPLFLKPGIPYSIKVQVKDSLDQFVGGVPVMLNSDGVASFVVNLPSGVALDFYVKTNAPDLPEDHAVAYSSLSQSYLYIDWALLVGELNLIVTPKSPYIDKITYNYLVLSKGKIVHFGTREKLMNIPVTQSMVPSARLLVYYIVSGEQTAELVSDSVWLNIEEKCGNQLQVHLSPSPGQSVSLSHSWVALTAVDSAVYGVQAKKPMERVFLGCGAGGGRNNAEVFNLAGLTFLTNANADEVLRPRRMLQQKIQEAAAKYKCLDGAETCEQRLARHCARAFNECCSIAQLGRLHTKTLLPPEIRSYFPESWLWEVHHVSVLPDSLTTWEIQGVGISSGLCVADTLKAKVFKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMMFCVKMVEGICTSLVTFSVLPLETGLHSINFSLETLVKTLRVVPEGVKRETAGVTLDPRGIYGVSRRKEFPYRIPLDLVPKTNERIVSVKGLLIGEVLSAVLSKEGINILTHLPKGSAEAELMSVAPVFYVFHYLETGNWDIFSPDLKKKLKEGIVSIMSYRNADHSYSMWKGGSASTWLTAFALRVLGQVNKYNLICNSLLWLVENCQLENGSFKDDQPIKLQGTLPVEAKENSLYLTAFTVIGIRKAFDLTALTKAESTFTLAIAAYALSLGDRAIASALKRAASVKPPIYRFWKDGLQGTAGMVETTAYALLTSLNLKENYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVDMDINVSYKYKITEKNFLGKPVEVPLDDDLVINGLATVHVATVVHKTSTSEEICSFHLKIERIIACASYKAESSSGSSHAVMDISLPTGISANQDDLRALVEGVDQLLTDYQIKDGHVILQVNSIPSDFLCVRFRIFELFQVGFLSPATFTVYEYHRPDKQCTMFYSTEGTLCKCVEADCGTISAEKACKPEIVYAYKVSITSVKYTATLLDVYKTGEAIAEKGSEITFIKKTTCNADLLKGRQYLIMGKEALQIKSFKYISWTWIEYNLDEFAEDIFLNGCE >XP_015815864.1 PREDICTED: complement C5 isoform X1 [Nothobranchius furzeri] KVLALLVCVWSYVITAPLSLHLDAVETVFVQLFGYTSEVPVYVFLRLNGYQVANVRLFPNKLGVNQVVLHVQTSQPIPISRTNGFLFIQTDKPLYTPNQKVKVRAFSMNQELRPANRSVFLTEQVPVDVVEMIDVGIPSMNPFKIPVKPKLGIWTIEAAYSDDFNTKATTDFEVKEYVLPSFSILMNPQTNHISFFRRFTFRISARYLHGAPVTEGLVYLRYGYVQTGEVDVTVDMDISSLVGSYLYIAVLVKEDTGGITQEAEFASVKFVRSPYHLSLISTPPFIKPGLPYNIKVLVKDHLDKPMSKVSVQLTSDGLVYFICHPLKNSRAVLKFQTADPTLPSSEPVAYQSPNQRYLYIDTSLEVGRTNIHVYTATPSYLNIRLNYLVLSKGKVVYFRTLNFVLNFQVTSSMVPSIRLLVYYVLHGEGTTELVADSVWMDVKDKCLNGLQMDVSLKPKDNVNLDDGLVALSAVDSALFTLRYKDPVFTVLQGCGGGGGKNNADVFRLAGLTFMTNANAHAVVRPKRASQEEINNKARRY-CERGMVTCERYAQQDCIKAFRECCEFFVLARTALGANFD-MVRSYFPESWLWEVQRTSSLPDSLTTWQIKAVGMFNGMCVADPVEVSVNLPLSVDVPLPYQVVRGEQVELRGSVYNQKEDSITYCVTLGPALCLLVVNFTVLGLEPGEHTLTFTLDVVEKLLRVVPEGVRQEVFGGILDPQGLYGSKRTVVLKNRLPENIVPKSDERLLTINGELPGDVATVLLNPEDLKQLISLPPGSAEAELQGLLPLIQVYQYLETTGWDVLGGDLRQKIKEGLVAISSFRNGDSSYSMWIKSEPSTIVTAEMIRALSMADAFQSLSDSVGWLIRRTQKEDGSFAEKRLIQILGGG-EEEVEQSVFVTSVALIALHRATSIASKRSAASVYVRALATYALTLQDSQLITSLEGLARQKPVTLRYWQESSVSSGQTVETTAYVLLTMLLKARSYANPILAWLTQDQHYGGGFFSIKDAVLTLEALTLYKSVMNQEINIRYKVSLSQTRPVATPIQVTKNDDITVRGVSSVKLKTVFYQTTASTQRCNFDLTIEHLVACVKYRPEVATESSLAVMKIQLPTGVEPYLEDLRQFRDDEESLVSHYELQGSTVIIQMDWVPSVFVCVGFRVRTGFKVVGATESWISVTEPQEKGSLCSKQFSSVDHQCQCMTAACATLTLEEICKEQIKFAYKLTVTSMTYTATVDQVLRPSNEAVSSGTEVDLVKKATCSVDLHDNRQYLVMGSSGSEVTGFRSVVDVLVSRTLMPWGLRVALQSVR >XP_030272007.1 complement C5 [Sparus aurata] KLCVLLMCVCTYLITAPLSLRLDAVETVLLQLFDFTDEVTVYVYLKANDYQAARVRLFPGQLDVSHVILHVQSPLSIPVSRTNGFLFIQTDKPLYTPDQSVKVRAFSLSQELRPAQRSVFLTQNVIVDIVEMIDAGIPSMNPFKIPIKPKLGIWSIEASYSDNFTTSARTEFEVKEYVLPSFSIQMEPESNFISYFNSFNFKVSARYLHGAPVADGEVFLRYGYISTGEVDVTVNMDLNSLVGMYLYVAVLLQEDTGGLTQEAEFAAVKFVKSPYSLSLVSTPPFIKPGLPYNIQVLVKDHLDKPVHRVRVRLSSDGLAVFICNVPSDGRAVLKFDTADPALPAAEAVAYHSPNQRYLYIDPGLEVGRARIKVYSATPSYVPVKLSFLVLSKGKVVEFGSQKFILSFLVKPSMVPSIRLLVYYILYGEGTSELVADSVWLDVRDKCVNGLQTEVSYKPKERFQLDEGLVALSAVDSALFILRYRDPVSTVLLGCGGGGGRDSADVFRLAGLTFITNANANAAVRPKRATEEQKKKKAHTY-CENGMMTCQKFADQPCRQAFRECCEFMVLGRNALGADFDSLVRSYFPESWMWEVQPVSTLPDSLTTWQIRAVGMFDGICVAEPLLVSVNLPLSVDVPLPYQVVRGEQLELKGSVYNQQPDPITYCVTLGPALCLLKVSFTVLGLEPGEHTLTFTLDILEKKLRVVPEGVKKELSGGTLDPQGRYGSKRTVELKNNLPINIVPNTAQRMLTVHGEVLGDVLSVALSPEGIRQLVNLPAGSAEAALDEVLPLIQVYQYLETARWDILGGDLRRKIREGLVAISSFRRGDSSYSMWMNSKSSTWLTAQVVKTLSAADQLQSLSESVAWLIRSSQQPDGSFTDARANKVMAAG-ANAVDQSVYLTSFVLIALHKATSIDSKTSAASLYVRAVATYALTLHDPTQLLHLERKAQSKPVVLRYWKEANVSSAQTVEMTVYVLLTLLLKGRQDANPVLSWLTQDQHYGEGFYSIQDTVLTLEALTEYSTAVDQDINIRNRVQLTQSRPVASPIQVTNNEDITARGVSTVKMKTVYYETTASNQNCNFDITIEHIVACAKYNPELSTESGLTVMKIQLPTGVDAYLEDLRQFRDAMEPSVSHYELQGHTVVIQMDAVPSRFLCVGFRIRTAFKVTGESESLFSVYEPQDKGSLCTKQFSSVGQQCQCMTAACATLTADETCKPHIKYAYKVTVVSMTYTATVVEVLKNSDEAVSSGTEVDLVKKITCAVDIQNNKQYLVMGSSGSEVKGFKYRSEALVELQLDDFALDLQLASCP >XP_040179981.1 complement C5 isoform X1 [Rana temporaria] MILLQIALLITYLVTGPRLWRIGAQETVVIQAFGQTENFPIKMSLLANKFQLINLQIQPKDLPMQYIYLQAQSKEKVAVIYENGHLFIQTDKAVYTPDQSVKIRVYSMDEELRPARRRVTLTEKVKMDIITQDDVGVISFPDFKIPANPRYGLWSIEAAYESDYVTSSLVKFEVKEYVLPRFFVTIEPERNFISHFKDFSVTVKAKYYYGRIVEKGKAFIRYGL-TNGEAVFQFNSSLEELEGALLYITATVEEEEGAQSEESENANVKYVLTPYRLTLIATPLFVKPTLPYHIKVQVKDTLENPASRIPLVLTIKGTSMFVINIPADVALDFRIKTDDPNLQEEKATSYKSLTKSYLYIDWVLQVGGLNVNIFPKSPYLHKLTYSYLIISKGKILKYDTVERLLNIQITVNMVPSFRLLIYYIVTGESTAELIADSIWVEVQENCLNNQKVKLSVKPKENVTLNGSIVALSAVDVSIFDVTAQRPLERVLLGCGAGAGQNNVDVFQTAGLTFLTNANIQAILRSKRSLEDEIKKEARKFQCMDGGNECKKGVERMCAKVFAKCCKLAQLGRMYIKTILNPEIRSYFPESWLWEEHAITSLPDSLTTWEVQGVSMSKGICVADPLTFTVFKDLFLDVQLPYSVVRGEQVQIKVIVYNYQPYKVMGCVRVGKEVCLVTFTYNLLPLELGLHPIIFTLEIVIKNLRVVPEGIQEENMGFTLDPQGIRGIKRNQDVAFKIPSSIVPKSKSRILSINGNILGEVIDTIVSGKSIQTLVSIPKGSAETDLMRVAPIFYVYHYLQTKNWSLLGPDMQKKLKDGVSSILAFRKGDHSYSLWRDSDPSTWLTAFALRTFGEVHKYMSVCNSLIWLIEKCQSKDGSFQEKLPIKLQGTIPREAAEKTLYLTAYVVIGIQKSLNMNALRLAVSMYTMAVCAYALQITDTQVMTKIKGEALTKPPVYRYWKDTLKETAVMVETTAYTLLAVLKSGDEYAKPVVRWLKEQQRYGGGFFGTQDTVIALEALTEVAILENMDVTISYRYQLTERNPFTKPVEVPILEDLLIYGIATGNVKTVYNIISPPQENCRFDLKIQLLEACAKYKPE-NPESGQAVMEITLVTGLLADEKSLNELVNRVDQFVVDYSLEDGKVVLHFDWIGSEYVCATLLVRKMFKVSLISPGIFKVYEFRAPDQACTAFYNPTGETCKCIEGECPTTTEDVACKGDITYVYKVQIVQVKYTAKILDIFKEVTALVKANKQIRFIKKKTCSFDLENGQQYLIMGKDGIQIREYKYESNSWIEWLLEGVTESILLEGCQ >XP_020749261.1 complement C5-like [Odocoileus virginianus texanus] MGLWGILCFLTYVISAPKVFRVGASENVVIQVYGYTEEFDATISIKENKFQSATLTIAPKQLSVSHVYLEVISKKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLTEGSEVYMVEENDYGIISFPDFKIPSNPKYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFIGYFTSFEITIRARYFYNKVVNEADVYISFGIRINGMAQVTFNSSLEDLNDKYLYIGVTIIESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEAVLEFNVKTNDPDLPDERAIAYSSLSQSYLYIDWHLLVGELNIVVTPRSPYIDKITYNYLVLSKGKIVHFGTRDKLINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSPSPGQRVSLNDSWVALTAVDSAIYGVQAKRPLERVFLGCGAGGGRDNADVFYLAGLTFLTNANADEILRPKRMLQKKIEEEAAKYQCYDGAETCEQRAARRCVKAFKECCAIAQLGRLHIKSLLPPEIRSYFPESWLWEVHHVPVLPDSLTTWEIQGVGISSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLDTGLHNISFSLEILVKTLRVVPEGVRRESAGVTLDPQGIYGTTRRKEFPYRIPLDMVPKTKKRTVSIKGLLIGEIMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVYHYLEAGNWNIFSTNLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYNSICNSLLWLLEKCQLENGSFKENQPVKLQGTLPVEAQEKTLYLTAFAVIGIRKSFDITAVSKADSAFTLAIAAYALSLGDKSIVSALKKKAFVKPPIYRFWKDDLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDIKVSYKYKISEKYFLGRPIEVPLNDDLVVSGLATVHVKTVTHKISTSEEVCSFHLKIERIVACASYKLESSSGSSHAVMDISLPTGVSANPEDLKALVERVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGVTCKCIEADCGTISAATACKPEIAYAYKVEITAVKYTATLLDIFKAGEAAAERDSEITFIKKTTCNANLEKRKQYLIMGKEALQIKRFKYISSTWIEYSLGEFAEDIFLNGCE >XP_043309645.1 complement C5 [Cervus canadensis] MGLWGILCFLTYVISAPKLFRVGASENVVIQVYGYTEEFDATISIKENKFQSATLTIPPKQLSVSHVYLEVISKKKMPITYHNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMVEENDYGIISFPDFKIPSNPRYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFIGYFTSFEITIRARYFYNKVVNEADVYISFGIRINGMAQVTFNSSLEDLNDKYLYIGVTIIESTGGFSEEAEIPGIQYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEVVLEFNVKTNDPDLPEERAIAYSSLSQSYLYIDWHLLVGELNIVVTPRSPYIDKITYNYLVLSKGKIVHFGTRDKLINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNVEEKCGNQLQVHLSPSPGQRVSLNDSWVSLTAVDSAIYGVQAKRPLERVFLGCGAGGGRNNAEVFYLAGLTFLTNANADEILRPKRMLQKKIEEEAAKYKCYDGAENCEQRAARRCVKAFKDCCAIAPLGRLHIKSLLPPEIRSYFPESWLWEVHHVPVLPDSLTTWEIQGVGISSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLEIGLHNISFSLEILVKTLRVVPEGVKRESAGVTLDPQGIYGTSRRKDFPYRIPLNMVPKTKKRTVSIKGLLIGEIMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVYHYLEAGNWNIFSTKLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYNSICNSLLWLLEQCQLENGSFKENQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDITAVSKADSAFTLAIAAYALSLGDKSIVSALKKKAFVKPPIYRFWKDDLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDIKVSYKYKISEKYFLGKPIEAPLNDDLVVSGLATVHVKTVIHKISTSEEVCSFHLKIERIVACASYKRESSSGSSHAVMDISLPTGVSANPEDLKALVERVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGVACKCIEADCGTISAATACKPEIAYAYKVEIIAVKYTATLLDIYKAGEAAAERDSEITFIKKTTCNANLEKRKQYLIMGKEALQIKRLKYISSTWIEYNLDEFAEDIFLNGCE >XP_004004015.2 complement C5 [Ovis aries] MGLWGTLCFLTYVISAPKVFHVGASENVVIQVYGYTEDFDATVSIRENKFQSATLTIQPKQLSVSHVYLEVISKKKMPITYDNGFLFIHTDKPVYTPHQSVKVRVYSLNDDLKPAKRETVLTEGSEVDMIEENDYGIISFPDFKIPSNPKYGVWTIRAKYKEDFSTTGTAYFEVKEYVLPHFSISIEPESNFIGYFTNFEITIRARYFYNKVVNEADVYISFGIRINGMAQVTFNSSLEDLNDKYLYIGVTITESTGGFSEEAEIPGIKYVLSPYKLNLVATPLFVKPGIPYSIKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEVVLEFNIKTEDLDLPEERAVAYSSLSQSYLYIDWHLLVGELSIVVTPRSPYIDKITYNYLILSKGKIVHYGTRDKLINIPVTQDMVPSARLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLEVHLSPSPGQRVSLTDSWVALTAVDSAIYGVQAKRPLERVFLGCGAGGGRDNADVFYLAGLTFLTNANADEILRPKRMLKKKIEEEAAKYKCYDGAENCEQRAARICIKAFKECCAIAQLGRLHVKSLLPPEIRSYFPESWLWEVHHVPVLPDSLTTWEVQGVGISSGICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLEIGLHNLSFSLEILVKTLRVVPEGVKRESAGVTLDPQGIYGISRRKEFPYRIPLNMVPKTKKRTVSIKGLLIGEVMSAVLSEEGIDSLTHLPKGNAEAELMSAVPVFYVYHYLEAGHWDIFSTNLKTKLKEGMASIMSFRNADYSYSMWKGGGASTWLTAFALRVLGQISKYNSICNSLLWLLEKCQLENGSFKENQPVKLQGTLPVEARENTLYLTAFAVIGIRKAFDITAVSKADSAFTLAIAAYALSLGDKSIVSALKKKAFVKPPIYRFWKDDLEGTARMVETTAYALLTSLSLKDNYVSPIIRWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLGNMDVKVSYKYKMSDKYFLGRPIEVPLSDDLVVSGLATVRVKTVVHKISTSEEVCSFHLKIERIVACASYKFESSSGSSHAVMDISLPTGVNANPEDLKALVEQVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGATCKCIEADCGTISAARACKPDIAYAYKVEIIAVKYTATLLDIYKAGEAAAERDAEITFIKKTTCNANLEKRKQYLIMGKEALQIKRIKYVSSTWIEYNLDEFTEDIFLNGCA >KAF4019645.1 hypothetical protein G4228_011172 [Cervus hanglu yarkandensis] MGLWGILCFLTYVISAPKLFRVGASENVVIQVYGYTEEFDATISIKENKFQSATLT------------------------------------------------------------------EGSEVDMVEENDYGIISFPDFKIPSNPRYGVWTIQAKYKEDFSTTGTAYFEIKEYVLPHFSISIEPESNFIGYFTSFEITIRARYFYNKVVNEADVYISFGIRINGMAQVTFNSSLEDLNDKYLYIGVTIIESTGGFSEEAEIPGIQYVLSPYKLNLVATPLFVKPGIPYSVKVQVKDSFDHLVGGIPVTLSSDGVASFVVNLPSEVVLEFNVKTNDPDLPEERAIAYSSLSQSYLYIDWHLLVGELNIVVTPRSPYIDKITYNYLVLSKGKIVHFGTRDKLINIPVTQNMVPSARLLVYYIVTGEQTAELVSDSVWLNVEEKCGNQLQ--------------------------------------VFLGCGAGGGRDNAEVFYLAGLTFLTNANAD----------------AAKYKCYDGAENCEQRAARRCVKAFKDCCAIAPLGRLR--------------------------------------------ICVANTLKAKVFKSVFLEMNIPYSVVRGEQIQLSGTVYNYRTSGIQFCVKMVEGICSSLVTFTVLPLEIGLHNISFSLEILVKILRVVPEGVKRESAGVTLDPQGIYGTSRRKDFPYRIPLNVVPKTKKRTVSIKGLLIGEIMSAVLSQEGIDILTHLPKGNAEAELMSVVPVFYVYHYLEAGNWNIFSTKLKTKLKEGMVSIMSFRNADYSYSMWKGGSASTWLTAFALRVLGQISKYNSICNSLLWLLEQCQLENGSFKENQPVKLQGTLPVEAREKTLYLTAFAVIGIRKSFDITAVSKADSAFTLAIAAYALSLGDKSIVSALKKKAFVKPPIYRFWKDDLQGTARMVETTAYALLTSLNLKDNYVNPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVNMDIKVSYKYKISEKYFLGKPIEAPLNDDLVVSGLATVHVKTVIHKISTSEEVCSFHLKIERIVACASYKRESSSGSSHAVMDISLPTGVSANPEDLKALVERVDQLLTDYEIKDGHVILQLNSIPSEFLCVRFRIIELFEVGFLSPATFTVYEYHRPDKQCTMFYSTEGVACKCIEADCGTISAATACKPEIAYAYKVEIIAVKYTATLLDIYKAGEAAAERDSEITFIKKTTCNANLEKRKQYLIMGKEALQIKRLKN--------NNREHAIDAFLNKLQ >XP_041428292.1 complement C5-like isoform X1 [Xenopus laevis] MIWLNVALLLTYLVTGPRTWRIGALETVVVQAFGQHGDFSIRINLLGNNYQLVKLMIQPQDFPMPFIYLQALSNEQVPVSYRNGFLFIQTDKPFYTPDQSVKIRVYSMDEELKPGRRKVVLTEEVKVDTIEEDDLGIISFPYFKIPANPKFGMWSIEAAYGKDFTTSGTVKFEVKEYVLPKFLVSIEPEQNFICYFTEFYITVRARYYYEKLVENAKVYIRYGL-NNGESVFQLNSSLEEVAGSYLYITVSVEESTGRV-EESENADVKFVLSPYTLKLVGTPLFVKPTLPYYIKVQLRDTLDKPVGNIPLTLSNLGIGLFILNIPSDISLDFTIKTDDSSLPEEVAVSYQSLTKSYLYINWVLHVNNLNVQLVPNSPYIAKLNYSYLVISKGKILQFGTVPRVLNLHITADMVPSVRLLVYYIVTGDATAELVADSIWVDVVESCVNHQSVQLSKKPGQTFSLKKSLVALSAVDTALYDVGFQRPLETVLLGCGAGAGENNADVFRLAGLTFLTNANIQEVLRPKRSFKDEVDKKASTYTCYDGVNDCAAGINRKCINAFEVCCLFAGMGRMYLRTVFDPQIRSYFPESWMWEEHLLDTLPDSLTTWEFQGVGMSKGLCVADQFKVTAFKDFFIDVQLPYSIVRGEQIQIKVVVFNYRNSDAKGCVTVGKEICLFPFTFSLLPLEVGLHPISFTLETVKKTLRVVPEGIKKERAGFTLDPQGIRGVRRRQEISYKIPSNIVPKSKSRILSISGNILGEVINTVVKSEGINYLVSLPKGSAETELMRVVPIFYVYHYLETNKWDLLGTDMQRKMRDGVNSILSFRGKDFSYSIWKEGKPSAWLTAFALKIFGEMEKYMSVCNSITWLLDKCQLRDGSFIDQQPGKLQGTVPSESEERSLYLTAYVFIGIQKSFHMEGLRRSESTFTLAIMGYALASWDVYVKGALEREAYVILPIQRYWKDSLKETARMVETTAYALLMYLKLALDYYNPVVRWLKEQQRYGGGFYSTQDTAIALEALTEVSIVDNMGVQVSYKYRLTETSSFTRPEEVPLPEDIIVNGIASVHVQTVYNIISPPQEKCRFDLRIGPVEACARYKAD-PSISGHAVMEITMVTGLTVDENELEELMQRVDQFVTAYDLENGKVMLHFDGIPSEYVCVTLLAWEQFKVAVLSPGIFSVYEFHAPEEECTTFFNPTGDKCKCIQATCPSITANVACKADVTYAYNVLVISIKYTASIQDIYKKGGDFVKAKKEVKFIKKKTCDIEIDQGEHYLIMGKEGIQIREFLYESDTWVEWTLSEFSDKMLFDRC- >XP_038046848.1 complement C3-like isoform X1 [Patiria miniata] ---AFLIFFAQYFIVAPNLVRVDVQETILVSVLGT-GENQIPVTLYRQDESEARLRIRRDQLPQQFVTLVASANRVILLSYQAGFVFIQTDKPLYTPKQRVDIRVVALDQDMVPVNNEMQVDDDIIVERYKQRPVGFLT-LSFVFPSNPVFGNWSVSAYYGHQFKASSTVQFEAKEYVLPKFYVEVAPQSLYIVP-QNLISKVTARYIFGEPVV-GNFYVKYGV-EVGEAFQDLDMWAETLMGKRLVIQAFVTDTATGETINTNNTQVTFSRTPYKFNWDLTQRYFKKGLSFSVKANVQFMSGLPAEDVPVIASPQGEVDFRLDVPAAAEITITLRTNNPDLVNATVLAQASSNNEYLVVRVVQRIGRSTVEVQLTHP--DNVGLNYFVIAGGRIVHKGAKNQVLGFEVTHEMAPSSRVVAYYT---DANGNVVADALLIDVEEKCKNPIGLSFLGRSGQNVQLEDTNVGLVAVDEAVFKLRHRLTQKKVFLGCGPGGGQTSATIFKNAGVTVMTNAQLDPVRRARRS-NDTEREQILSNYCEKGMLTCAQRAKLPEIRAFFDCCSVL----------VNILVRSNFPESWLFDNVITQTLPDSVTTWVIEAVGVHHEMCVAEPIKLEVRPPFFLDIGMPYSVQRFEQIEIVASVFNYGDDELEVTVYLKEGLCSISVKFVIVPLEVKNIPIEIVADAIEKDLTVRPEGYEKKIVPVTLDPANYRGSAKQDGIRYSVNRNAIPGSHAR-MSLVGNVLGSVIDTVLG--GLDKLLRIPGGCGEQTMLGLAPNVYVYTYLKHTDF-----SSERYVFNGVKHELTFRKNDGSYAAFTSRPSSTWLTAFVAKIFCKAKDFSNICKAMEWLITQRQQDDGSFTERIHKEMSGGV-----QGKASMTAFVLISLLECE--DSVAAATRPYAIAITAYALALANSI--QMLKDIAAYN---SRYWAADDSPKAIEVETTSYALLALLQMEEQYTHAIVNWLTNQENYNGGFVSTQDTVMALQALSEYAYKVDINCEVKCDFSLNPANALVRNIDVPMSQEMNVAGMGQFKFEATYYIPEPDVTECDFDLLINSYDIQVRYLR--GEKTGMAILDVGLYTGYKAVQEDLQTVMDNSGGRVERYEETDHSVVFYFEDIPGEAIRIQFRAEREFNVGKVQPVAVHVYDYYNPTEECVKFISPVEDTCVCAAGKCADYKVYMACASKAHFAYEVTVTDQFYTMTIDAPLKQGLDHVVKDATRVFAKSKSCTPDLQMTK-YLVIGSGGLPTKQDIYKDRTFFYEKLTELKQELVGEGCA >XP_011661993.2 complement C3 isoform X2 [Strongylocentrotus purpuratus] LIVAIFASMAKIFITAPNVFRVGVNETVTVSVFNTDQDQDVEVTIYRRGTPTTSVRVEPEHYSNQYVYLVASAPKEVLLSSRSGYLLLHTDKPIYTPNQEVKIRMVVVDQDMKPSSELIHLMQGIIVEQFRETRAGFMN-KTFTFNTEPMFGNWSVTVLHGLQFEKNKTIKFEVKEYVLPRFTIKINTPDFILESRESLDINFEAKHVYKKPVG-GNFHMEIGI-ENGIGTSSIYPWFRSYEGCRLNVEVVVTEASTGVTERAVDISTMIVRSPYRFRTGQTVQYFKPALPYEVQFELETVLGKPAQYLDVNIEANGRVRFIFNTTQDMQINIRVSTEE-NIEQEDANPYQSPDDDYLSISIVFRVGDLYVVARTTAS--TPIDLNLLFLSQGKVILAKSIDHMVFFSVSSDMVPMVRIIAYYI---NQLDQVVADSIALKIENTCKHHVAINIKELPETPVTLLTSYVGLLGVDKAVYALNHRLSRKKMFIGCGPGGGPTSPVIFKDSGLSVLTNALLASSSRRKRSCQSNSRSRIEYCLCDDNLCTCETIASKYCPQAFSQCCELMSIGEDSTD-TFEMDVRSDFRETWLFDLIRVGQTPGSITEWSLQAVSVTGGLCVTDPLDVNVFKSLSIQLQLPYSVVRSEQIEVLATIYNYNAQGATVRVSFPKGTCGESLKFVIVPVEIGDLPITVTADGVQKILNVIAHGVPQSVHSVMLDPSGIYRQRRSPRLDLRPPENIIPGTEAV-LSLIGNMLGPILVDPVA--NYGEWLAYPRGCGEQTMSIVAPTIFVLKYLQTMKM-----MAMDRISRGLASVLSHRREDGSFTIWGLYSSSTWLTSFVLKVFSHANTLNVTCKAAEWLVLNAQNPNGSFSELHHTEMTGGI-----SGEASMTAYVLIALYEGHW-LALRNAQRPYAKAIVTYALALSRSN--RMLRNDAIIL--GSRYWTPNEAPSAIAIETTAYALLAQLELGDTYAGSIALWLSEQQNYEGGFISTQDSVLALQALTRYSEMADLSCVVTSEHRFLTHNALVREVAVPVGGRLRSKGTAKLAVRMKFNRLPSSQDVCPFNVTYNTIRFCARYTQ--NTRTNMGIIDVGLYSGFVLVSERLEDMVQTDHHLVQRYEVSQRSVIFYLDEIPAQDICMEFNARREIHVGNVQPVAIRVYDYYSPDKSCTSFYHPSADQCICPSERCA-----KACESSDNYALRVTMMSTVYIGNVTRVVRTGQDDVSPGMLRHFYIKERCCPRIKLNGEHTIIGSAGLSFIADGYKDRSIVEWKLLNFEQDAQ---CT >XP_031565662.1 complement C3-like [Actinia tenebrosa] SKMLLTLLTISYVITAPNIFYVGVPQPIHVALFDVKWSHTIELELRDNGKLSLTVGPEVSKFQRGFVYLLSRIKTKVNVSYSDGVILIQTDKPIYTPKQTVKIRVVPLGFDLMPSAKKINLVHGIGVRQWESLNTGFIS-KNIDIGSYALAGIWTIEAYYGHQFLYNASSRFEVREYVLPRFSVKISNPLYILPTLDSFKVKGTAKYTYGKPVQ-GTATVRLSI-VNGEFEHPIKMWFPE--GYRLHIEADVTEKSTGKTERAVERSVYFVTTPYLIEYVNTARYFKPGLPFSIVVIVKFTNGQVARKIPMKVLDNGRAEFVINIARQVELQIKVKTNLQNIPKEVMDA--SESHELMKLRQPARVGTAVCDAVLTSK---TVDLTYFVISRGQIIYSATIKKLISFKVTSPMSPSSRLFAYYVS--KETGRVVSDSILLEVEHKFPNPIFLKDSDPPSMPYNIKGTKVGLLGVDQSVYLLSNILTADSVFLGCGAGSGRNSEDMFRNAGMVVLSSDIEVEHKRERRS-------------CSLGNRSCFRRLKDDCRKTFWMCCIHKDFGDEQQE--DDIQTRQYFPETWINKELTISSLPDTMTTWVVQAIGVSAGFGIAKPLHITTFKPFFIYLSMPYSVQRGEEITILATLFNYKNYDVSVHLFLDQGFCSAAFPITIVPIKFGKVPIEVIADRVLKTLNVVPEGIEERLQSYVLDPQELLKGKEREEIKLDIPKNAIPGSIAK-AYFTGNMIGQALTNLAAG-QMVSLLQMPDGCGEQNMVRIAPNVYILHYLKKTNM-----KKEKFIQEGYIHELNYRKKDGSFALFKYNKGSTWLTAFVLKVFCQASKLNVLCQSAKWLIGN-QRQDGAFVEH--RSIQGGV----YTSDVTLTAAVVIALKQCQ--SAVERAVDAYSLAITTYALVLANSN--QKLIQKATYN---NRYWETGSK--ARNIETAGYALMAQVALNREYAGPIVVWLTKQRSFGGGFVSTADTCVALESIAKYSEQRDLRIRMK--MRITKNNAFMQEADLTTGDEVGISGVGQMQVDIKYNVPYKENERCDFDVKVIVLRVCTKYRK--SGQTGMAIIEVGLVTGFSADEDTLIKLVEKKNNSIERYELSDRAVVFYVNQIVNRRICIAFHLIRIFDVGIIQPVPIKVYXYYEPDTKCTLFYNLKKEKCKCTQGMCA---IDEVCNVY-NYAFKGKVVGMTYQINITQIIKQGSSIFQTQKAYLFNKPGICYPDFEFEDEVFIMGKNKNGVQ-----RDTFVKTKIAKH-----HGKCT >XP_039271128.1 complement C3-like [Styela clava] LLQLCMQLFINHLLIAPQILREGVRETAVLNLYNIDGRIDVVATVKTKPIIKIKYDKPPGVLPRQYVELLVSAKLRMRLIESSGYIHIQTDRPIYRPEERVNVRVIALTQTQSPEHREVEIVDNVGVEKKLLRMPKFID-TSFELPEYPVYGIWSIQARYTDEKVVRSTTTFDVRPYVLPTFNVRVLLDDPYVLVNEYIRGTITAEYSYGRKVS-GPYFLAAKL-RGGKQRFEIKATFDDLEGATIEIDVAVTGEAEGVVESDRSRPIMFVRSPYQLDISRMSKYYTPRTSFEIKIDVLDVTNSPVKKVELILAENGQVNFKIGMDKDPKRTYTIQTRKLGIPRETLHPYISSSGSYLQLSAIAEVGDFGIDVWYK----SAPSISYVIMARGAIISTGVHIPKIKIEVKGEMVPSFRFFVYFF----SGKELLSNSLWIDVKDACKQELQVKVPASPSQVFNVENAILGMSAVDRAAYFLYGRLTRSSVFEGCVREGGKNAQHVFEEAGLQVVGGPYSATLKRKKRS-PKNIVAKLEKE-LMDGSTSCVERAEAECAEKFLKGCEDYVAG-------FQNNVRSNFEENMLWATDVILVAKDSITTFEFDTVSMHDGFCVAPTQNVTIFKDTFVQLKLPYSLKRMEQAEIRATVFNYATTSKRVTVHVGEDICSHATSLVLMPLRVPDIEVKITNDHVKRSILVLPEGIKNDIGTYAIDLKNKRPSIDRFKIELRFPKRYIPGSRCW-IYPFSNYMGPIIETKQPKNDIKNLIRLPGGCGEQTMLSMGPNVMAHKYLKLVGMK----GSIDKMQKGFANELKYRTSTAPWSVFPRRAPSVWLNAYVNKIFAQAKQFGPICTSINWLVDQ-QNPDGSFDTGIHQEMHGAV-----GSTLSLSAYVMMSLVESQSIISILKATQPYALSLVCFALSVSNPRMRKKLLSKINYS---LAFWKGAPLAKAIDVEATGYALLSILYAQSDVTRKIVLWIIQQRDEKGGFSTTQDTVVGLQALAEYMIWSKIDLTISSALHLDKSNENSTPISIPSGGELNIEGEGTLSYRCVYRTL-VDEDACHFDISVSKLKLYISKPK--GEPSGQSIVEINLISGYEVMEDTLVKLSETVDASIERYEIAKQKVFLYLSDI-TVPKKLAFRISRSVYVGRPEPSTVTVYDYYEPSVRCSKFYNVSEDICKCAEGGCLTICHDTACKSDYVYEVKVTSDGMDFAIQIVEVYKAGDLDVDRNQNRNFSVRRDCKEPFLKKDRTLLMIGNGVEMNDNILKAGIFVERKLKKKREECLHQSCN >CAE1304902.1 unnamed protein product [Sepia pharaonis] ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TNVEIQRATVGLSAVDKAVYLINNKLTRKLVKLACSPGGGLHVGQVFYHAGFVIMTQDLDRSFGRYRRA-------------CISGRHNCKVAWQEFCRSAFMQCCNPAPSARLRQD--AKPIFSLYFPESELFQEYRLNTLPDSLTTWHIQGMSLSSPFCVSKPISLTTFKNVITKLNFPRVVKRLEQIYIKAVVYNYKTHPINVKVNFTKEICSHVAGVVIVPLKAGNFTIHIEVEIIEKVLHVKYEGVKKTNFSLMLDPSGTYSGKRHRRMKLTQPAEAIDGSAGD-IVITGNILGSTIQTTLK--EPHKLLDKPYGCGEQTMIFLAPCVYILSYLNSTNG-----NATRYIRLGILREQEFRKMDGSYAAFDQNPSSVWLTAFVLKVFCQASEFHLTKSAMTWLFQK-QRLDGSFIEDIHQEMVGGV------NDRVMTAFVLISLMECGYKNEIDLAIDTYDMAIISYALALADSR--IKLRSMAIEN---YLYWRVGGYESYLSVEATAYALLTEMHYGEEHVGPIVKWLIEQRNSAGMFKSTQDTVMALQALAEYGIKTNLFFNLTSSLTVNKETSLWIIPDVPMNDEVLIIGSAQMELNMWYYRPPTQRETCHFNVTHICMKIYLRYLG--TSDPGMVVLDMDLLTGYDTHEELLEQLK--LDRLIAKYKHGNSRLTLYFNTIPFKEIEIKLLMFRMIYMNRLMPAPINVYVYYNATESCTKFYQLSKKVCKCAQRDCVNIKLKKSCAKE-QIVMIVNMTSTAYGFVQEDLSKT--DIPDLEEHVAIFQKGICCPHVKVGEIYLIMANKRVRTLQYRHKSSGLM--EIDIFEQKARQAFCG >XP_006565503.2 alpha-2-macroglobulin-like protein 1 isoform X1 [Apis mellifera] VFLVLFICSVGYVFTAPKKLYAGEIETGCLSLHNLELPAHVHLELVKTGTECLQLAVPSPIYRTAILRLKIKFDTDVEIEHDSLLTFVETDKPTYKPGQDVKIRILMLMHDLKPWQKSIPEVSFVKVKQWTNVSTGMAQ-LTFPLSPEPSLGSWHIKVMKKKPYPNLHSTTFKVEKYVLPKFQMTINSPQYILANVENVTWNICVKYSYGKPVK-GNLLLKLTP-DKGDGCTDFVLKMD---PNNIVLIAEFTEAGTGIVETTISRTVVLHEALKLEYEHYTPKYFKFGLPYHGKLRVLRYDDTPAPNEKIQICTDGFVDFVVP-PQHKIVLLSFVATAVDYPTTTVNPWYSPSDSYLTVARPIVCGEYSFNVMYTTSSMNETIFHYSINSKGSILIYGHVKHKLSVKVTPSMAPVSELLLYYV---RSDGEIVATTYTIEVGHCFENKVKSTWHTIPGSPTQYHRSLCAISAVDKSTLFLSNLMSSTQTF--------PTPKFYFPWENSRCKSAIGPEQFLRSKRQYSKRVN------YVDFGVRPCPWLFMEISTNE-------YDSGIGYVD-QNQATLRSYFPETWLWELVPIGTLPHTITDWVGYTTCISHGLGIAPPTTITAFQSFFLDYNLPYSIKRGEIMRFKVSLFNYMHHSLPVKIKLMEKIDLHVHEYILKPRVIGEVNITVTADVIVKPILILPEGFPVEEKSALICPKDSSDDSFM--WELTLPKDAVPDSGAY-LNLIGDILGPALE------NLDKLIKLPKGCGEQNMILFVPNNHVIKYLDAMRN-----KAIRNMEKGYQRELKYRFMDGSYSAFEEGESSIWLTAFVLKSFAQAASLYVLESSVSWITMN-QLEDGCFPVIFHKSMKGGL--QEHGSSSALTAYILISLLESG--SVVNDAQDLYTTVLTTYVLALLEHM--KSLMNRATRY---LIWWEDKSKSIGLSIEMTAYVILTLLKLGESEALKAVRWISKQRNSEGGFTSTQDTILGLEALTKYAMIVDLSVLVTASYKLQDENRVIKQIRLPLPTIVEIEGCVLIQSNLKYNVASSTGS-DAFDLSAEEITICSRYKM--DEESNMALLEVGIISGYVPDRASLHSLLDPS-SKVKLFEEDQDIVTIYFNKL-TQKTCISFRIIQEYFIDHLKPANIKLYDYYQQELTVSTNYKIVDEQLTTPNEMIIPVYVKPTVQTEDEEPIRIDTDNMKEVLRIVKILKINETNVPSPTRIN----QSCCMDVLPSNISDIYCSANSAVKRFRKVLRAMIEFKDNDFQKQTLGVPCK >NP_001366904.1 TEP (ThiolEster containing Protein) [Caenorhabditis elegans] LLILNILFVVTYMLVAPAVVRPDQPFSVCMNLLKQATDEDMIVRIEKPGIATVSLSEMPAQSLKLYIRGETLNANELKYDQKALSVFIQTDRAIYRPASLVRYRAIVVKSDLKPYVGNATIKSRNLISQTIGVTLGVYS-GELQLAEETLLGDWFIEVETSNGVQ--DKSSFTVDTYVLPKFEVNIKTSSFITIN---LSVFVDAKYTYGKGVA-GKAKVSLEL-RQGEAAVVFSNLLHEWGGGSIRIVASVTEDITEIERNAT-HQISTFREEVKLDVEKQGDTFKPGLTYNVVVALKQMDDTPVKTLPKRVQAHGTSVLTLQPPINCSARIEAHYDIGGKDNFYVEAAVSPTKSFLQLLAAVDVGKLSFSLKATQP----LSITYQVMSRSNIVVSQQMT--ISFPATANMAPKSRLIVYAII--ESSQEVLVDALDFKVEGIFQNQVALSIDKEPGQNVKFKNSFVGLLVVDQSVLLLKNDITREKVEVGGGFGGGSDAQSIFSNAGLVVLTDALLYEFMSERRL------------TMMDGA--------------------------------SSPTVRKFFPHTWIWSDLNSTEAPDTITSWVASTFAINNGLGVAPTSKLRVFRPFFIQLNLPYAVRRGEKFALLVLVFNYMEKEQDVTVTLDKDSGYDAVYFPIVPSSIGEIPVHISADAVEMNLRVDPQGYKVDRIPFVIDLNNNSSDSKN--LELIWPNDVVDGSQAR-LDVIGDMMGPVLN------NAHKLVQMPYGCGEQNMLNLVPNILVVKYLRATNN-----KAIKFIEQGIQRELTYKRADNSFSAFGDKAGSTWLTAFVVRSFHHAKQYNVISRAVAFLNSQ-QMESGAFAERHHKDMQGGA----QDGGVALTAFVLISILENG--MENGKAVNAYTMAVVAYALQLAKSF--ENLKKHKIVE---VKFASAQKKARPVDIETTSYAVLSYLAQNQSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSYAAVTTSQVTILNGFDINIRNAIVQSYQLSLNDAVSITGVVFAQLSYSYYRDSLNDD-APFFCSQEQLDLCCNYTR--PGKSNMALAEIDALSGYRFDAEQVHTLTSIEDQRVEM-EKDDTKMNVYFNPL-GRPVCLSLYSDVTYQVADQKPANFRLVDYYDPEEQLKMTYAA-GEDC-----------------------------------------------------------------------------------------------SLPPFDESTV----- >NP_523506.1 Thioester-containing protein 2, isoform A [Drosophila melanogaster] IFLTGIILQYIYSVVGPGTLRSNSKYNVVVSVHKADGPSQIKVSLNQNVEFVPKLATGNYNLS-----------TKLNYADKKPSVFVQTDKATYKPADLVQFRILFLDENTRPAKIEKPISAQNRIKQLSDVKLGVFS-GELQLSEQPVLGTWKISVSVDGDNR--ETKSFEVDKYVLPKFEVIVDTPKAVVIA--VIKATIRAKYTYGKPVK-GKATVSMER-VDGKGHVEFDIYLPP-----IKLFAVVTEELTGNKQNAT-ATVVLHQQRYSIEPYERPEHFEANKSFIYQVVVKNVDGSPVTNSAKNVKENGIATFNVRLPDSDRYYRIFASFDGSENTIEPTPM---SREPLKIQVKPRLGEVSFDVVS----IEDLPFVYTIVARGNVILSDYVDVPVKFTPTFSMVPKATIYVYYVV----NNDLQFEEKTIDFEKEFSNSIDVSAPTKPSEEVKLRDSFVGLLGVDQSVLLLKNDLSQDDIFNGYGRYPGQT-------SGLVTLTNANYP---------------------VFEGSHPWITRPRYGDRISFL-----SLL-------KQTTTIRKEFPETWFFEN--VGKIPDTITSWVVTGFSLNSGIALTKPSKIRVFQPFFVSTNLPYSVKRGEVIAIPVVIFNYLDKTLDADVVMSDQEYEFSVSFMIRPKNVGFTTLKITADAIHQKLKVEPEGVTLFERAVFINLKDQ-PESQS--LDADIPNEVVPQSEIE-FSVVGDLLGPTLQ------NLDNLVRMPYGCGEQNMVNFVPNILVLKYLEVTGK-----KARKFLEIGYQRELTYKHDDGSYSAFGDASGSTWLTAYVMRSFHQAGTYKVITAGLDFLVSK-QKESGEFPEVFDN---------ANQNPLALTSFVLLAFFENHELSAIKKAVDQYSLAIAAVALQLAKHI--AKLESVARKE---RMWWSKATEPRSNDVEITSYVLLALLEKDPEKALPIIKWLISQRNSNGGFSSTQDTVIGLQALTKFAYKTTMDIEFSSAIKVNPENSLVQTHDLPSTRKVDFTGSAMVQLSYRYNLAEKEKK-PSFKVTPTIVDVCAEYVPDKDKDSNMAVMEIALPSGFVGDSTSLGKIQAVDRKRVET-KNSDSTVVVYFDSLTPDVRCLPLEASKAHAVAKQKPASVSLYDYYDTERKATEYYQVEGADCG------------EGCKKD-------------------------------------------------------------------------------------------
PhyML tree of selected proteins (((CAE1304902_1_unnamed_protein_product__Sepia_pharaonis_:1.2914666,(XP_039271128_1_complement_C3_like__Styela_clava_:1.49921095,((tr_E7FCV2_E7FCV2_DANRE_Complement_component_5_OS_Danio_rerio_OX_7955_GN_c5_PE_1_SV_2:0.43736858,(XP_030272007_1_complement_C5__Sparus_aurata_:0.13481968,(XP_015815864_1_PREDICTED__complement_C5_isoform_X1__Nothobranchius_furzeri_:0.18944378,XP_011478017_1_complement_C5__Oryzias_latipes_:0.26907835):0.09349806):0.41487813):0.32138626,((XP_041428292_1_complement_C5_like_isoform_X1__Xenopus_laevis_:0.27148959,XP_040179981_1_complement_C5_isoform_X1__Rana_temporaria_:0.28691064):0.23919482,(((XP_005512961_1_complement_C5_isoform_X1__Columba_livia_:0.05778014,(XP_415405_5_complement_C5_isoform_X1__Gallus_gallus_:0.01984552,XP_003207914_2_complement_C5__Meleagris_gallopavo_:0.0280183):0.06024713):0.13512627,(XP_014382164_1_complement_C5__Alligator_sinensis_:0.00443431,XP_014459225_1_PREDICTED__complement_C5_isoform_X1__Alligator_mississippiensis_:0.00549234):0.130223):0.10660056,((NP_001001646_1_complement_C5a_anaphylatoxin_precursor__Sus_scrofa_:0.07985718,((XP_023098426_1_complement_C5__Felis_catus_:0.04042851,XP_038512006_1_complement_C5_isoform_X1__Canis_lupus_familiaris_:0.08332772):0.02012555,((XP_008271599_1_PREDICTED__complement_C5_isoform_X1__Oryctolagus_cuniculus_:0.06852195,(NP_034536_3_complement_C5_preproprotein__Mus_musculus_:0.0742099,NP_444179_1_complement_C5_precursor__Rattus_norvegicus_:0.02893897):0.08251192):0.01620156,(XP_030870703_1_complement_C5_isoform_X1__Gorilla_gorilla_gorilla_:0.00540204,(sp_P01031_CO5_HUMAN_Complement_C5_OS_Homo_sapiens_OX_9606_GN_C5_PE_1_SV_4:0.00450044,((XP_016817059_1_complement_C5_isoform_X1__Pan_troglodytes_:0.00000001,XP_024785786_2_complement_C5_isoform_X1__Pan_paniscus_:0.00000001):0.00634746,XP_024108622_1_complement_C5__Pongo_abelii_:0.01354578):0.00528106):0.00000001):0.04935313):0.02107999):0.01478284):0.01195373,((XP_020749261_1_complement_C5_like__Odocoileus_virginianus_texanus_:0.01201107,(KAF4019645_1_hypothetical_protein_G4228_011172__Cervus_hanglu_yarkandensis_:0.01064402,XP_043309645_1_complement_C5__Cervus_canadensis_:0.00081733):0.01556473):0.0050134,(NP_001160088_1_complement_C5a_anaphylatoxin_precursor__Bos_taurus_:0.01751617,(XP_004004015_2_complement_C5__Ovis_aries_:0.00360969,XP_013821764_2_PREDICTED__complement_C5__Capra_hircus_:0.0054461):0.02246524):0.01730335):0.04259753):0.28049739):0.1018974):0.10228283):0.71415095):0.04827177):0.06885297,(XP_031565662_1_complement_C3_like__Actinia_tenebrosa_:0.96771745,(XP_038046848_1_complement_C3_like_isoform_X1__Patiria_miniata_:0.81548466,XP_011661993_2_complement_C3_isoform_X2__Strongylocentrotus_purpuratus_:0.96095436):0.15076978):0.11772619):0.51042962,XP_006565503_2_alpha_2_macroglobulin_like_protein_1_isoform_X1__Apis_mellifera_:1.42150284,(NP_523506_1_Thioester_containing_protein_2__isoform_A__Drosophila_melanogaster_:0.96211613,NP_001366904_1_TEP__ThiolEster_containing_Protein___Caenorhabditis_elegans_:0.914063):0.4070176);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)