PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0077 | P04114 | Apolipoprotein B-100 | APOB | FCHL2, FLDB, LDLCQ4, apoB-100, apoB-48, apolipoprotein B | Homo_sapiens | Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. |
Domains | Gene Ontology |
PF01347 (Vitellogenin_N) PF06448 (DUF1081) PF09172 (DUF1943) PF12491 (ApoB100_C) |
GO:0005319 (enables) lipid transporter activity
GO:0005515 (enables) protein binding GO:0005543 (enables) phospholipid binding GO:0008201 (enables) heparin binding GO:0035473 (enables) lipase binding GO:0050750 (enables) low-density lipoprotein particle receptor binding GO:0120020 (enables) cholesterol transfer activity GO:0001701 (involved in) in utero embryonic development GO:0006629 (involved in) lipid metabolic process GO:0006642 (involved in) triglyceride mobilization GO:0006869 (involved in) lipid transport GO:0007283 (involved in) spermatogenesis GO:0007399 (involved in) nervous system development GO:0008202 (involved in) steroid metabolic process GO:0008203 (involved in) cholesterol metabolic process GO:0009566 (involved in) fertilization GO:0009615 (involved in) response to virus GO:0009743 (involved in) response to carbohydrate GO:0009791 (involved in) post-embryonic development GO:0010033 (involved in) response to organic substance GO:0010269 (involved in) response to selenium ion GO:0010628 (involved in) positive regulation of gene expression GO:0010744 (involved in) positive regulation of macrophage derived foam cell differentiation GO:0010884 (involved in) positive regulation of lipid storage GO:0010886 (involved in) positive regulation of cholesterol storage GO:0016042 (involved in) lipid catabolic process GO:0019433 (involved in) triglyceride catabolic process GO:0030301 (involved in) cholesterol transport GO:0030317 (involved in) flagellated sperm motility GO:0032355 (involved in) response to estradiol GO:0032496 (involved in) response to lipopolysaccharide GO:0033344 (involved in) cholesterol efflux GO:0034374 (involved in) low-density lipoprotein particle remodeling GO:0034379 (involved in) very-low-density lipoprotein particle assembly GO:0034383 (involved in) low-density lipoprotein particle clearance GO:0042157 (involved in) lipoprotein metabolic process GO:0042158 (involved in) lipoprotein biosynthetic process GO:0042159 (involved in) lipoprotein catabolic process GO:0042632 (involved in) cholesterol homeostasis GO:0042953 (involved in) lipoprotein transport GO:0045540 (involved in) regulation of cholesterol biosynthetic process GO:0048844 (involved in) artery morphogenesis GO:0071356 (involved in) cellular response to tumor necrosis factor GO:0071379 (involved in) cellular response to prostaglandin stimulus GO:0120009 (involved in) intermembrane lipid transfer GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005737 (located in) cytoplasm GO:0005769 (located in) early endosome GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0005789 (located in) endoplasmic reticulum membrane GO:0005790 (located in) smooth endoplasmic reticulum GO:0005811 (located in) lipid droplet GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0010008 (located in) endosome membrane GO:0012506 (located in) vesicle membrane GO:0030669 (located in) clathrin-coated endocytic vesicle membrane GO:0031904 (located in) endosome lumen GO:0031983 (located in) vesicle lumen GO:0043025 (located in) neuronal cell body GO:0043202 (located in) lysosomal lumen GO:0043231 (located in) intracellular membrane-bounded organelle GO:0070062 (located in) extracellular exosome GO:0070971 (located in) endoplasmic reticulum exit site GO:0071682 (located in) endocytic vesicle lumen GO:0034359 (part of) mature chylomicron GO:0034360 (part of) chylomicron remnant GO:0034361 (part of) very-low-density lipoprotein particle GO:0034362 (part of) low-density lipoprotein particle GO:0034363 (part of) intermediate-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0042627 (part of) chylomicron |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |