PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0074 | O60687 | Sushi repeat-containing protein SRPX2 | SRPX2 | BPP, CBPS, PMGX, RESDX, SRPUL | Homo_sapiens | Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. |
Domains | Gene Ontology |
PF00084 (3_Sushi) PF02494 (HYR) PF13778 (DUF4174) |
GO:0005102 (enables) signaling receptor binding
GO:0005201 (enables) extracellular matrix structural constituent GO:0005515 (enables) protein binding GO:0036458 (enables) hepatocyte growth factor binding GO:0042802 (enables) identical protein binding GO:0001525 (involved in) angiogenesis GO:0007155 (involved in) cell adhesion GO:0042325 (involved in) regulation of phosphorylation GO:0048870 (involved in) cell motility GO:0051965 (involved in) positive regulation of synapse assembly GO:0071625 (involved in) vocalization behavior GO:0090050 (involved in) positive regulation of cell migration involved in sprouting angiogenesis GO:0098609 (involved in) cell-cell adhesion GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005737 (located in) cytoplasm GO:0009986 (located in) cell surface GO:0030054 (located in) cell junction GO:0045202 (located in) synapse GO:0060076 (located in) excitatory synapse GO:0097060 (located in) synaptic membrane GO:0062023 (part of) collagen-containing extracellular matrix |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |