PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0072 | Q8IUX7 | Adipocyte enhancer-binding protein 1 | AEBP1 | ACLP, AE binding protein 1 | Homo_sapiens | May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. |
Domains | Gene Ontology |
PF00246 (Peptidase_M14) PF00754 (F5_F8_type_C) |
GO:0000977 (enables) RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001227 (enables) DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0003677 (enables) DNA binding GO:0004180 (enables) carboxypeptidase activity GO:0005201 (enables) extracellular matrix structural constituent GO:0005516 (enables) calmodulin binding GO:0005518 (enables) collagen binding GO:0008270 (enables) zinc ion binding GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II GO:0006355 (involved in) regulation of transcription, DNA-templated GO:0006508 (involved in) proteolysis GO:1904026 (involved in) regulation of collagen fibril organization GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0070062 (located in) extracellular exosome GO:0062023 (part of) collagen-containing extracellular matrix |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |