PB0068

DATABASE

Click here to access PB0068 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0068	P16112	Aggrecan core protein	ACAN	AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, SSOAOD, aggrecan	Homo_sapiens	This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Domains

Gene Ontology

PF00059 (Lectin_C) PF00084 (Sushi) PF00193 (4_Xlink) PF07686 (V-set)

GO:0005201 (enables) extracellular matrix structural constituent GO:0005515 (enables) protein binding GO:0005540 (enables) hyaluronic acid binding GO:0030021 (enables) extracellular matrix structural constituent conferring compression resistance GO:0030246 (enables) carbohydrate binding GO:0046872 (enables) metal ion binding GO:0001501 (involved in) skeletal system development GO:0006508 (involved in) proteolysis GO:0007155 (involved in) cell adhesion GO:0007417 (involved in) central nervous system development GO:0031012 (is active in) extracellular matrix GO:0005576 (located in) extracellular region GO:0005796 (located in) Golgi lumen GO:0043202 (located in) lysosomal lumen GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P16112|PGCA_HUMAN Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPV TTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEV QSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSA IIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNE TYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAG WLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPEN FFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVF HYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVS PRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCES HNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQT GLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTA VPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEV PSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEE PYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLD SSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSG EVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVL ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT APGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPG VEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVED ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISG LPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPS GEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLET TAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSA SGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSAS EVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAP ETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEG RGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPS GFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPS GLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPS GEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSG AYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSG FLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSE FVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESS SETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGE ASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPES EWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPA RSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRET WVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFEN WRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFG QKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRH PRRSRPSTAH >tr|F1R511|F1R511_DANRE Aggrecan b OS=Danio rerio OX=7955 GN=acanb PE=4 SV=3 GTSLYLICLENSTLSVSIPVEQPLRPLLGGSMVIPCYFQDITLQDPGTLTSPTNAPLSQR IKWSHIHKGKISLILVATEGQVQVETEYLDRVHLVNYPMVPSDATIEISELRSHDSGTYR CEVMQGIDDNYDSVEMQIQGIVFHYRAISTRYTLTFEMAKAACIQNSAVIATPAQLQAAY DDGFHQCDAGWLSDQTVRYPIHEPREPCYGDKDNFPGVRTYGVRDVNETYDVYCFAEKMS GRVFYSMSVEKFTFADAEDQCAKLGAQLATTGQLYLAWKTGMDVCNAGWLADRSVRYPIN IARPQCGGGLLGVRTVYLFPNQTGYPYPDSRYDAICYEEDKVLIKTTPFPEIYTTTDSSD YTEQVTTEGEVRGQILTDEPFNTTSTESPLSPPLNITDVEEDIINVATAPPSLEHAIPSI NVTAKIKGVVFHYRAESGRYAYTYEEAQDACQKLGAVIATPELLQAAYEAGLHQCSAGWL QDQTVRYPIVHPRKKCSGDSEDVPGVRSYNVRPAHEQYDVYCYMDQIKGEIFHVSSLAGF TYYEAVAHCRKLSSTLASTGELYAAWNQGFHKCSPGWLADRSVRYPVGSPDFDCGGNKTG VQTIYAQPNQTGSPHPYSRYDAYCFKGITAQCVFVQVFHPIVPPLFVDMSGSGSGSGYAS ASTSGSGSDSASGSASGVPDSSSGYISGSGIASGSASGSGQSGDGSGFLVRYQEGTDALM WSSASGSASEAKDGSGSGIIITSGIQSGDQESGEESGHFAVASGLPSGLGSGISGSGTSG FFSGEESSGSGFFSVSFVDTKMIDLTARAFGEQELSGFYTAESGFPSGSGSFSGFETGSA IGFESNSAFGSGSGFETGSAIGFESNSASAFGSGSSSGFESSSAFGFGSGSASGFGSGIA SGIESSPASAFGSGSASGFGSSSAIGLESSSASGFKSVSVTGTSGYPNHPSAPFDPCDPN PCGQGLCSLQDGVALCQCHSGFSGENCSMLVQGCAEGWMEFMGSCYIHFDERETWTSAEQ HCQELNSHLVSISSQQEQEFVKTQAQDYQWIGLNDKDVQNEFRWTDGSPLEYENWRPNQP DNYFSTGEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCTTPPEVQNARMLGNSKDRY PVNSFIRYQCNSGFTQRHLSVVRCLPDGQWEKPRVECIRGIENNRLRKRSLYIRPKAVNS RTWRKVL >tr|E7F537|E7F537_DANRE Aggrecan a OS=Danio rerio OX=7955 GN=acana PE=4 SV=3 MLSLLLLSMCLWVFSATASFDYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTV NDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASI KITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQN SAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDV NETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCN AGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGSG FFPLDLELTTDGDNGVLTVDTITESHTVISKPASTESEVQGEVVTYKPSVTTSVENPYTA LDISHVLPSPPTSSVEKDPDFGSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQ LACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRS YGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQ GFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKED LDLPLNESESQETVTEEKIVSISSHPALHRPEGTPIIAPSPTEPSGTEESVASSSGDLLS SGSGDQPSGSSVSSGDSSGTSSTDDLLTSGSGDQSGSGSSVTSGDYSGASGTDSLFSSGS GDRSSGSFSSSGDFSGASGTDDLLGSGSGEQPSGSFVSSGDFSGASGSGDMSSGSGSSSG SGSGLDILVTFSGIDTVFSGVGSTSGQLEEAGEGSTEILTFQLDQISGSGSGLGSGSGYS SEESGSTSDLSSSSGESGESGDLSGISSGSGFSEESSGFSGFASGIFPSGGSSDISFIDG SGIIMVDRPWMKISSFLTEQELGSGQVDFSGSGLFSGSGVSGDISGLSGEISGSSGDSSG ISSDISGMSGDISGMSGDISGISGDITGMSGDLSGMSSSDHSGSGSGLAFSGVTFLGSGF TDLTEQSREQEASGLVFFGSGEGSGFRSGGYAIESGERSGDSASSDVIFFSNNDMVEMSN KPLQGMELGRGEVEYSGTVRLSSGSGDDQSVFISGHEWIPVTANTPSVKSTDPPPAELFD QGPSDLYSDTAGHLGPYLKPEEIINNLDAVPLAALSSTTETASLQRPAVVERPAVNDYLN PCEPNPCGAGVCSVKDGVGLCHCPPGLHGEECQFDSHSCEKGWTKFQGNCYLHFSKRETW LDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENW RPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGN KKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFGLHDKSVHHSHK ARTALEKQL
Selected proteins from model organisms >sp|P16112|PGCA_HUMAN Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPV TTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEV QSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSA IIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNE TYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAG WLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPEN FFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFAEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVF HYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVS PRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCES HNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQT GLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTA VPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEV PSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEE PYTPSPPVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLD SSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSG EVLETSASGVGDLSGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVL ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETT APGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPG VEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVED ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISG LPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPS GEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVDEISGLPSGEVLET TAPGVEEISGLPSGEVLETSTSAVGDLSGLPSGGEVLEISVSGVEDISGLPSGEVVETSA SGIEDVSELPSGEGLETSASGVEDLSRLPSGEEVLEISASGFGDLSGLPSGGEGLETSAS EVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAP ETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEG RGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPS GFPDTSGETSGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPS GLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPS GEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSG AYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSG FLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITSE FVEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESS SETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEGE ASAAPEVSGESTTTSDVGTEAPGLPSATPTASGDRTEISGDLSGHTSQLGVVISTSIPES EWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPA RSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRET WVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFEN WRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFG QKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRH PRRSRPSTAH >XP_043345769.1 aggrecan core protein isoform X7 [Cervus canadensis] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISK EKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAI STRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNE TYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGG NLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILT AKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQ PRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGS LRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAA VPVGEETTATPGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEP FPSEKPFPPEELFPSEKPFPSEKPFPSEKPFPSEEPFPSEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPVP SRTELPSSGEASGVPEVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWT SAPKVDRLPSGGEGPEVSASGVEDISGLPSGGEVHLEISASGVEDISGLPSGGEVHLEISASGVEDISGLPSGGEVHLEI SASGVEDLSGLPSGEEGHLEISASGVEDLSVIPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSV SGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGVE DLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSASGVEDLSRLPSGEGPEVSASGVEDLSVLPSGEGHLEISASGVEDLS RLPSGEGPEVSASGVEDLGVLPSGEGHLETSASGVEDLSRLPSGEGHLEISASGEEDLSRLPSGEGPEVSASGVEDLGVL PSGEGHLETSTSGVEDLGVLPSGEGHLETSTSGVEDLSRLPSGEGHLETSTSEVEDLSRLPSGEGHLETSTSEVEDLSRL PSGEGHLETSTSGVEDLSRLPSGEGPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSRGEDHLETSASGVGDLSGL PSGRDGLEISASGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDF SGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGET SGLFGVSGQPSGFPDISGETSGILEISGQPSGFSGEISGMTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGI PDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTPTTFKEEEGLGSVELSGLPSGEADLSGTSGLV DVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQ EAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSREPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLP EVTLITSELVEGVTEPTVSQELGQRPPVTYTPQLFETSGEASASGDVPRFPGSGIEASSVPESSGEMSAYPEAEVGASAA PEASGGASGSPDLSETTSTFHEADLEGTSGLGASGSPSAFPQGPTEGLATPEVSGESTTTFDVSVEASGSPSTTPLASGD KTDTSGDLSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTDASIPTSAGGTDDSEA TTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSH LSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNY QLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQ KRSSRTLRRSRPSTAH >KAB0352492.1 hypothetical protein FD754_017349 [Muntiacus muntjak] MVNLQALLEKKFEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATE GRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRA QRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEM EGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLH ANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTA PEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHY RPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRP PSETYDVYCYVDRLEGEVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPA CGGEKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPIGEETTATP GFTVEPENKTEWELTYTPAGTFPLPGAHRRPFCNGSALSLREAVPLRGTIPPRGTIPLRETIPPRGTVPFREAVPLREAI PLRGTVPLRXXXXPSEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVPEVSGDFTGSGEISGHLDFSGQPSGESA SGLPSEDLDSSGLTSTVGSGLPSESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSASGVEDISGLPSGGEGHLEISASG VEDISGLPSGGEVHLEISASGVEDLSRLPSGEGPEISASGVEDLSGLPSGEEGHLEISASGVEDLSVIPSGEGPEVSASG VEDLSRLPSGEGPEVSASGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGVGPEVSASGVEDLSRLPSGEEGHLETSTSGVE DLSRLPSGEGHLETSTSGVEDLSRLPSGEGXXXXTSGVEDLSRLPSGEGPEVSASGVEDLGVLPSGDGHLEISASGVEDL SRLPSGGEDHLEPSASGVGDLSGLPSGREGLEISASGAADLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASGL PSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGG ASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQPSGFSGEISGVTELSGLPSGQPEISGE ASGILSGLGPPFGITDLSGETPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTPTTFKEEE GLGSVELSGLPSGEADLSGTSGLVDVSGLSSGATDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLP SGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDF SGTTDVSGESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQELGQRPPVTYTPQLFESSGEASASGDVPRFPGSGIE TSSVPESSGEMSAYPEAEVGASAAPKASGGAFGSPDLSETTSTFHEADLEGTSGRGASGSPSAFPQGPTEGLATLEVSGE STTTFDMSVEASGSPSATPLASGDKIDTSGDLSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQT ADTATSPTDASIPTSAGGTDDSEATTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGH CYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFF ATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRC QPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSHPSTAH >KAB0369135.1 hypothetical protein FD755_019140 [Muntiacus reevesi] MVNLQALLEKKFEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATE GRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRA QRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEM EGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLH ANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTA PEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHY RPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRP PSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPA CGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPIGEETTATP GFTVEPENKTEWELTYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEE LFPSEKPFPSEKPFPSEKPFPSEEPFPSEKPFPPEELFPSEKPFPSEEPFPSEKPFRPEEPFPSEKPIPSEEPFPSEKPF PSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVPEVSGDFTGSGEISGHLDVSGQPSGESASGLPSEDLDSSGLTSTVGS GLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSASGVEDISGLPSGGEVHLEISASGVEDLSRLPSGEGPEISASG VEDLSGLPSGEEGHLEISASGVEDLSVIPSGEGPEVSASGVEDLSRLPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGVE DLSRLPSGEGPEVSASGVEDISRLPSGEGPEVSASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGEGPEVSASGVEDLX XXLPSGEGHLETSTSGVEDLSRLPSGEGPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSGGEDHLETSASGVGDL SGLPSGREGLEISASGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQGPEASGLPSGFSGEYSGVDLGSGPSSGL PDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSRLPFSELDISGGASGLSSGAELSGQASGSPDIS GETSGLFGVSGQPSGFPDISGETSRLLEVSGQPSGFSGEISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGET PGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTPMTFKEEEGLGSVELSGLPSGEADLSGTS GLVDVSGLSSGATDSSGFTSQPPEFSGLPSGVTEVSGEAYRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAT TAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAAMSTSGEAS GLPEVTLITSELVEGVTEPTVSQELGQRPPVTYSPQLFESSGEASASGDVPRFPGSGIETSSVPESSGEMSAYPEAEVGA SAAPEASGGAFGSPDLSETTSTFHEADLEGTSGLGASGSPSAFLQGPTEGLATPEVSGESTTTFDVSVEPSGSPSATPLA SGDKTDTSGDLSGHTSGLGIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQIADTATSPTDASIPTSAAGTDD SEATTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQ QSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVP CNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKR RLQKRSSRPLRRSRPSTAH >OWK08890.1 ACAN [Cervus elaphus hippelaphus] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISK EKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKAISTRYTLD FDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCF AEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRT VYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEV SPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGV VFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTY GVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPVGEET TATSGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPF PPEELFPSEKPFPSEKPFPSEKPFPSEEPFPSEEPFPSEKPFPPEELFPSEKPFPSEEPFPSEKPFPPEEPFPSEKPIPS EEPFPSEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVPEVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD SSGLTSTVGSGLPVESGLPSGEEERITWTSAPEVDRLPSGGEGPEVSASGVEDISGLPSGGEVHLEISASGDLSRLPSGE GPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSRGEDHLETSASGVGDLSGLPSGREGLEISASGAGDLSGLISGK EDLTESASGDLDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTAT TAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGIL EISGQPSGFSGEISGMTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLV SSAMSGSGESSGITFVDTSLVEVTPTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSG LPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSG DHLGSLDQSGLQSGLVEPSREPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQELGQ RPPVTYTPQLFETSGEASASGDVPRFPGSGIEASSVPESSGEMSAYPEAEVGASAAPEASGGASGSPDLSETTSTFHEAD LEGTSGLGASGSPSAFPQGPTEGLATPEVSGESTTTFDVSVEASGSPSTTPLASGDKTDTSGDLSGHTSGLDIVISTTIP ESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTDASIPTSAGGTDDSEATTTDIDECLSSPCLNGATCVDAID SFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIG LNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARI FGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRTLRRSRPSTAH >KAF4017792.1 hypothetical protein G4228_009467 [Cervus hanglu yarkandensis] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISK EKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAI STRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNE TYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGG NLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILT AKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQ PRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGS LRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAA VPVGEETTATPGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEGSXXXXGGEVHLEISASGVE DLSGLPSGEEGHLEISASGVEDLSVIPSGEGPEVSVSGVEDLSGLPSGEEDLSRLPSGEGPEVSASGVEDLGVLPSGEGH LEISASGVEDLSRLPSRGEDHLETSASGVGDLSGLPSGRDGLEISASGAGDLSGLISGKEDLTESASGDLDLGRIPSVTL GSGQAPEASGLPSGFRGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSG LPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGILEISGQPSGFSGEISGMTELSG LPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLV EVTPTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSL PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSRE PASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQELGQRPPVTYTPQLFETSGEASASG DVPRFPGSGIEASSVPESSGEMSAYPEAEVGASAAPEASGGASGSPDLSETTSTFHEADLEGTSGLGASGSPSAFPQGPT EGLATPEVSGESTTTFDVSVEASGSPSTTPLASGDKTDTSGDLSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESS SPVHSGEESQTADTATSPTDASIPTSAGGTDDSEATTTDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSS IVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLP FTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRS SRTLRRSRPSTAH >XP_041442785.1 aggrecan core protein isoform X2 [Xenopus laevis] MTTLLLVFVCLRVIAAAISVEVTDHHNTLSVIIPLDLPLNVQLGHSLTIPCFFINALDGVTVAPSTAPLTPRIKWSKHVK GKETVLLVATDGHVRVNEAYNGRVSMPTYPLAPTDVSLEISNILSNDSGTYRCEVMHGIEDSQATVEVNVKGVVFHYRAI STRYTLDFEKAKKACIQNSATIATPEQLQAAYDDGYHQCDAGWLSDQTVRYPIHNPREACYGDKDMFPGVRTYGVRETDE TYDVYCYVEDMQGEVFYATSPEKFTFDEAEKQCKSLGARLATTGELYVAWKSGMDVCSAGWLGDRSVRYPISIARPNCGG NLVGVRTVYLHPNQTGYPNPLSRYDAICYKAGPDEDITIQTITQPSLEIIIPRNDTEEEARGSIASLEPTNFTLTPTDLE EFFTATPELVLTEGPFENVTEEVFPLENITALAQTEAPGTVNVTFSEGPEFNATTSLEEEIVPVTAAPAEVEPEKHIAKT GVVFHYRAASSRYSLNFTEAKKACLVNNAIIATPAQLQAAYEAGFDQCDAGWISDQTVRYPIVTPRENCHGDKNGFPGVR NYGVVNPAARFDVYCFIDKLHGEVFFATQPDQFTFQEANEFCDEQNATLASTGQLYVAWKLGLDKCRAGWLSDGSVRYPI VTPRKACGGDIPGVRTVYLHANQTGFPDPLSKYHAFCFREEIPEIPSIKEEVIVTQVVSELETLPSGEGPTAEIETTTDF ENQTDFWMANVTESPTIEPSVTVSPSVVPIVSPAPEDISGETSGIGSAISGEPSGVPSGEVSGDVSGADLSGQPSGTEES GFPSGTDISGVSGLPSGDVSGDVSGDISGDVSGDISGEEPSGEPDISGLHSGFPSGAEDISGQVSGFPDISGLSSVPIET SGLSSGELSGDEIISGSASGIEIISGFSSGIEDVSGIASGFPTITHVDTTWVESVTKPTETELEGKGEIEFSASSGIELS GDLSGLESSGDLSGFDLSGVTSSVIESSGDISGFISGDISGEPSGMIDLSGEVSGVTDISGELSGLKDFSGEASGVLDFS GELSGLSGESSGIISVSSGYSGDIGISGEASGIREISGELSGVPDISGLGSGILEIPSGVILIDQSLKELSQPPKKEEEG KGSVGISGFYSGDVDSSGDISGILDVSGEPSGLIDISGFMSGGIPSGDIDISGLSDISGAVSGSEYVSGLQSGFDDVSGV PTVSHIDFTLKEPPTQGPDTQEAGGSPSVILEFSGIASGETLPSGTHEGSLESSGIYTSGSVTLITDDSVEAITKPAVSQ ELGGVTFAYTIETSASGDIGTETSATHETSGKQETTLEGSTEPSSGHITFLAPESSGEISETSESETTHAPEEAQQETEL VTSVASGEVTDEPTIETASPSSPITIESEGVIGSCADQPCGAGTCTEKEGRIYCACPAGFGGDLCNIDLEVCEDGWTKFQ GHCYKHFSERETWVDAENVCRYHQSHLASILSPEEQEFVNSNAQDYQWIGLNDKTIENDFRWSDANPLQYENWRPNQPDN FFTTGEDCVVMIWHERGEWNDVPCNYHLPFTCKKGTVACSDPPAVQNAYTLGKKKVRYEISSLVRYQCNQGYLQRHVPII RCLPTGHWDEPRILCIDLSTYRRHKRSPRSRSRAIATSEQGKAH >XP_030269061.1 aggrecan core protein-like isoform X2 [Sparus aurata] MIRWIVLLSLCLHVISASFDYIYEEHSFMDPEDVLSVSIPLEGPQRPLLGGSLVLPCYFEDHTVPDPGAPTITPLSHRIK WSLVTKEKVTTILVALEGQVRISESYLDRVHLVGYPVTPTDASIKISELRSTDSGVYRCEVQQGIEDNHDIVHVQVQGIV FHYRAIMGRYTLTFEKANAACTQNSAVMASPEQLQAAFDDGFHQCDAGWLSDQTVRYPIHDPRVNCYGDKEELPGVRTYG VRDLNETYDVYCFTEKMTGRVFYTAAAEKFTFSEAEASCANRGARLATTGQLYLAWQGGMDVCNAGWLGDRSVRYPINIR RPQCGGGLVGVRTVYLHTNQTGYPLPESRYDAFCYTESPDEEGSGFIEEGSGVLSVTTVTQSPEVFFRRTTTESEAVGEV ETQQPTVVDFTYTLSPTELPLPQPPNVTELITDLIEPATARPDVGREPSKDFVMPPTGVVFHYRSDSGRYAFTFVEAQRA CQSVGASIATPEQLQAAYKAGFHQCDAGWLLDQSVRYPIVFPRDKCTGDLGDQPGVRSYGLRPADERYDVYCYIDGLKGE VFHVRSAEGFTYDEAASSCQEQNAVLASTGELYAAWKMGFDKCRAGWLVDGSVRYPINKPRSECGGGKLGVHTVYANPNQ TGFHERDAKFDAYCFRADLLLIANETGLNITEIQEVLLNISSITDLLRPAVPSIVPPIPVETSGSGSGSADFGSGSASGD NSGDSSGSGDLAASGDGVISGDLSGSGDLSGSGDLSGSGDRVVSGDSSGSGDLSGSGDRVVSGDLSGSGDLSGSGDRVVS GDLSGSGDLSGSGDRVVSGDSSGSGDISGSGNQIISGDLSGSKDLAGSASAELPSGASGFSSTDASGSTLSGEGSGITVV FSGIDSIVSAEGSISGEPQEAGEGSTGILIFPSTGEGSGELSGSGDLSGSGSGSGFTSMGSGSGGSGQFSGMSSGFINGQ DFSGFSGFPSGSYSGSASGQSGELSGSGDAQILLIDGEMIDVSIRTTNKEYELGGGLLEFSGSGDISGSGVLSGDLSGSG DISGSGILSVDLSGSGDISGSGILSVDLSGSGDISGSGILSGDLSGSGPRSGTEFFSGVTFIGSGFTELTGSSSGEQEAS GYLLYSSGQGSGGHLSGYGGLIYHSGSGSGMSGSEFSTSGEEGSVTFLTGDFMTELSRDTTPSMELGQGSVEYSGEGSGS GGFFSGSGDNRLFTASGTSSGVSSADLPLVVLPSTSSEWALTETTAGPEEALSGTELSQTSGDIDETYGSAPAPAGLAAP PTAATPASLQATGTAAEMDSVEGVFNPCEPNPCGDASCTVEDGVPVCHDEQQCEDGWTKFQGNCYLHFSDREMWLDAEQR CRDLNAHLVSIITPEEQHFVNSNAQDYQWIGLNDKTVQNDFRWTDGTPLQYENWRPNQPDNYFNSEEDCVVMIWHENGQW NDVPCNYHLPFTCKKGPVSCSAPPEVENAHMFGTRREEYPVNSIIRYQCNPGFTQRHPPVVRCRADGQWEKPQVECTDVK ARRRTQRRSGGRH >XP_023807578.1 aggrecan core protein [Oryzias latipes] MIRLTLLTSLSLSLVSAAFDYISEAHSFMDPEDVLSVDIPLEEPQRPLLGSSLVLPCFFQDHTVPDPGAPVIPPLSHRIK WSFVTKKNVSTVLVALGGQVRIGKGYLDRVQLLNYPQTPEDASIRISELRSSDTGVYSCEVQLGIEDDHDFVQVYVTGVV FHYRSFMGRYALTFEEAKTTCSQNSAAIASPEQLQAAYDDGFHQCDAGWISDQTVRYPIHDVRVNCFGDKEDLPGVRNYG VRDPREKYDVYCFAEKMTGRVFFTTSVEKFTVSEAALACSRHGAQLATTGQLYIAWQGGMDVCNTGWLADLSVRYPINVR RPQCGGGLLGVRTVYLHPNQTGFPLPESRHGAFCYADSPDDKSLNSGSGSGDESGPWRVSTVTKDPQLLFSWVTSESEVV GEMETQASSALNVTNFENPKMLVSPTVIITEAMEAINRPGVGKEPNTGSTMPPAGVVFHYRSHTGRYTFNFSEAQLACQS VGGSIASPQQLQAAYESGYHQCDAGWLLDQTVRYSIVVPRDKCAGDLGDQPGVRSYGMRPADERYDVYCYIEDLRGEVFH LESADGLTYDQAVLSCQEHGGILASTGELYAAWKTGFDKCRAGWLQDGSVRYPINIPRARCGGGKHGVHTVYAHPNQTGF PPREDRYDAYCIRSELLVQKNTLYEQYQHHLINNNCCTSTVNILLTANETGPNATDNHNKQLNHTSVADSFRLSLSSIVP SVYVEMSGSGSGAENTAPEFAGGCIFMNHCGELSGSDFGDQIISGDYTSSTDPPGGVVTNSSGSGLSGSRITDTSGSSLS ESDNMDGSGAGLSGSSNINGSRSGFNGTNHVDSLGSGLSGSTSMDGLESGLSGSNSTDDTGSGLGGSNSTDYTGSGLSGS NSTDDTGSGLSGSNITNNSGSRLSGSDRTDDPGSGLSGSTRTDDPGSGLRGSNITDNSGSGLSGSDRTDDPGSGLSGSTR TDDPGSGLSGSKITENSGSSHSGFSSIDGSGSGFIGPSGVDNSGSGLSGLSSVDSSGLGLSGSNSTDDKGSGLSGSNSTD YTGSGLSGSNSTNDTGSGLSGSNITNNSGSRLSGSDRTDDPGSGLSGSTRTDDPGSGLRGSNITDNSGSGLSGSDRTDDP GSGLSGSTRTDDPGSGLSGSNITENSGSSHSGFSSIDGSGSGFIGPSGVDNSGSGLSGLSSVDSSGLGLGGSSTIIAIGS ALSGYSNFDDSGSGLSGSSSTDGLESGLSGSSSADGSGSTLNGGGYNIPVVLSKLESFALEGGSALSREVKEGRPAILFF PSSVEGSGEPSGSRNLSWSGPKTGLASVDSGFSVESSGGSKALSGTTSGFILHQDFSGFKGFTSGSLSGSGSGQTREFEG SGNPQIFLIHDKLMDASVNQKQHELGGGPPVLSGSGDFSGSGILGGSFSDSDPESVSVLSSDVTSIGSGIPEVSVSSAAE HKQASEILLHSSGQGGEIQLSGLRGSTFVSQSVSGFSRSDIPSNEDKVKNLFLREDPNRQRKSRERGSEDHSGDGSQSGN GDAIATTAFFLGETSGHKQAEATTKPEKVTEVPVDGSEHVPAGLEARLITAEPAFEETSRITEDLDVCHPNPCANGATCV ESADSFRCLCLPSYGGERCDVDEQHCAEGWTKFQGNCYLHVSKRETWPGAEQHCRSLNAHLVSIITPEEQQFVNANAKAY QWIGLNDRTVENDFHWTDCTPVQYQNWKQNQPDNYGSGENCVVMIWLKNGLWNDEPCHYHLPFTCKKGPVSCGEPPHVVN AVMFGRKRLEYPVRSIVRYQCNPGFRQRHSPVIRCQADGLWETPRVECVDAKARTRAGAGIIRRLPSATQGTARSS >KAF7212766.1 aggrecan core protein-like [Nothobranchius furzeri] MWKDTQKPSVVSEVQDHTFPDPGAPPIVPLSHRIKWSHVTKEKVTTILVALEGQVHISKSFLDRVHLLSYPQTPTDASLK ITELRSSDSGVYRCEVQHGIEDNHDIVHVHVQGIVFHYRAIMGRYTLTFEMAEAACSQNSAVVASSEQLQAAYDDGFHQC DAGWLSDHTVRYPIHDPRVNCYGDKEELPGVRTYGVRDLSETYDVYCFAEKMTGGVFYTTSAEKFTFSEAESACSRQGAQ LATTGQLYLAWKSGMDICNAGWLRDGSVRYPINIRRPQCGGGLLGVRTVYLHTNQTGYPLSESRYDAFCYTEAPDEESSG AAEGSGVLSVTSVTQSPELFFSRVTTESEVIGEVETQLPLDLNETESQTEPSLLQPPSVDDPIEAATAQPGVYKEPSETF VVSSEDVVFHYRSSAGRYAYMFVEAQLACQSVGGSIATPQHLQAAYEAGYHQCDAGWLLDQTVRYPVVFPREKCAGDLGD EPGVRSYGLRPADERYDVYCYTGKLTGEVFHVGSAEGFTYDEAVSSCQNHSAVLASTGELYAAWKMGFDKCRAGWLLDRS VRYPINNPRSECGGGKSGVHTVYAHPNQTRYPELDAKFDAYCFRANVLHQTNKTQLNITVIQEALLNKTSVIDLLMLNVS SIVLPIPVEMSGSGSGLADFGSGSVNGSISGDHSGNLSGSGNLPGSGDGLTSGDSSGSGDISGSRDMSGSGALSGSGDLS GSGHQSSSGDSSGSGHQSSSGDSSGSGHQSSSGDSSGSGHQSSSGDSSGSGHQSSSGDSSGSGHQSSSXXXXXXXXXXXX GDSSGSGHQSSSGDSSGSGHQSSSGDSSGSGHLAGSTSTGGSGSGLSGVGSGITFFFSGADNIVSEEGTSSGGPQEAGEG FTENCIVSSSGSWSGCSSGDLSPSGSGSGATKSEDSLGGSGHFSGSTSGFTSGQDLSGFLSGSSSGSGESGELSGSGDLQ IVLVDEKLVHASTTLKENELGAGPLVFSGSGDLLGSSSGSGLSGELSGSGDLQILQIDENLIDESTAQKGYELGAGPHVF SGSGDHSGLGVFSGDHSGSASRSESEFVSGVILMGSGLMELTVSSSGEHKEASGIVFYSSGQGSGGQISGFGSSSFLSGS GSELSGSAVSGSGFSASGEEGSVKLLTDDLIKAPRQTEAPQELGQGSVQYSGEESGSSFSGGRVFDLSTAPGAPTSSVAS TEDLSEAVLPSPPAEPVPTEPTRLPEDHPNEAEETETFSETYMMPSFERIPEGLVAPPTAAKPAFVETPATAGEVEVCHP NPCANGATCVESADSFKCLCLPSYGGKHCKIEEQQCEDGWTKFQGNCYLHISDRKDWLGAENHCQGLEAHLVSIITPEEQ HFVNAFANDYKWIGLSDKAVERDFQWTDGTPMQYENWRPNQPDNYFNSGEDCVVMVWHEKGQWNDVPCNYHLPFTCKKGP VSCGAPPEVENAHTFGARRLQYPVNSIIRYQCKPGFRQRHLPVVRCQDDGHWEKPRVECTDVKARKRIQHRSSWDPAVSS TEK >NP_001348429.1 aggrecan core protein isoform 1 precursor [Mus musculus] MTTLLLVFVTLRVIAAVISEEVPDHDNSLSVSIPQPSPLKVLLGSSLTIPCYFIDPMHPVTTAPSTAPLT PRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEDDITIQTVTWPDLELPLPRNVTEGEALGSVILTAKPIFDLSPTISEPGEALTL APEVGSTAFPEAEERTGEATRPWGFPAEVTRGPDSATAFASEDLVVRVTISPGAAEVPGQPRLPGGVVFH YRPGSTRYSLTFEEAQQACMHTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATRLEQFTFQEARAFCAAQNATLASTGQLYAAWSQGLDK CYAGWLADGTLRYPIITPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVAPSPGEEGGSTP TSPSDIEDWIVTQVGPGVDAVPLEPKTTEVPYFTTEPRKQTEWEPAYTPVGTSPQPGIPPTWLPTLPAAE EHTESPSASEEPSASAVPSTSEEPYTSSFAVPSMTELPGSGEASGAPDLSGDFTGSGDASGRLDSSGQPS GGIESGLPSGDLDSSGLSPTVSSGLPVESGSASGDGEVPWSHTPTVGRLPSGGESPEGSASASGTGDLSG LPSGGEITETSTSGAEETSGLPSGGDGLETSTSGVDDVSGIPTGREGLETSASGVEDLSGLPSGEEGSET STSGIEDISVLPTGGESLETSASGVGDLSGLPSGGESLETSASGAEDVTQLPTERGGLETSASGVEDITV LPTGRESLETSASGVEDVSGLPSGREGLETSASGIEDISVFPTEAEGLDTSASGGYVSGIPSGGDGTETS ASGVEDVSGLPSGGEGLETSASGVEDLGPSTRDSLETSASGVDVTGFPSGRGDPETSVSGVGDDFSGLPS GKEGLETSASGAEDLSGLPSGKEDLVGSASGALDFGKLPPGTLGSGQTPEVNGFPSGFSGEYSGADIGSG PSSGLPDFSGLPSGFPTVSLVDSTLVEVITATTSSELEGRGTIGISGSGEVSGLPLGELDSSADISGLPS GTELSGQASGSPDSSGETSGFFDVSGQPFGSSGVSEETSGIPEISGQPSGTPDTTATSGVTELNELSSGQ PDVSGDGSGILFGSGQSSGITSVSGETSGISDLSGQPSGFPVFSGTATRTPDLASGTISGSGESSGITFV DTSFVEVTPTTFREEEGLGSVELSGFPSGETELSGTSGTVDVSEQSSGAIDSSGLTSPTPEFSGLPSGVA EVSGEFSGVETGSSLPSGAFDGSGLVSGFPTVSLVDRTLVESITQAPTAQEAGEGPSGILEFSGAHSGTP DISGELSGSLDLSTLQSGQMETSTETPSSPYFSGDFSSTTDVSGESIAATTGSGESSGLPEVTLNTSELV EGVTEPTVSQELGHGPSMTYTPRLFEASGDASASGDLGGAVTNFPGSGIEASVPEASSDLSAYPEAGVGV SAAPEASSKLSEFPDLHGITSAFHETDLEMTTPSTEVNSNPWTFQEGTREGSAAPEVSGESSTTSDIDTG TSGVPSATPMASGDRTEISGEWSDHTSEVNVAISSTITESEWAQPTRYPTETLQEIESPNPSYSGEETQT AETTMSLTDAPTLSSSEGSGETESTVADIDECLSSPCLNGATCVDALDTFTCLCLPSYRGNLCEIDQEQC EEGWTKFQGHCYRHFHDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRW SDGHSLQFEKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGDPPVVEHARTLG QKKDRYEISSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPNTYKHRLQKRSMRPTRRSRPSMAH >XP_038956962.1 aggrecan core protein isoform X1 [Rattus norvegicus] MTTLLLVFVTLRVIAAVISEEVPDHDNSLSVSIPQPSPLKALLGTSLTIPCYFIDPMHPVTTAPSTAPLT PRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDLELPLPRNITEGEARGNVILTAKPIFDMSPTVSEPGEALTL APEVGTTVFPEAGERTEKTTRPWGFPEEATRGPDSATAFASEDLVVRVTISPGAVEVPGQPRLPGGVVFH YRPGSTRYSLTFEEAQQACIRTGAAIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATQMEQFTFQEAQAFCAAQNATLASTGQLYAAWSQGLDK CYAGWLADGTLRYPIVNPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVAPSPGGTPTSPS DIEDWIVTRVEPGVDAVPLEPETTEVPYFTTEPEKQTEWEPAYTPVGTSPLPGIPPTWLPTVPAAEEHTE SPSASQEPSASQVPSTSEEPYTPSLAVPSGTELPSSGDTSGAPDLSGDFTGSTDTSGRLDSSGEPSGGSE SGLPSGDLDSSGLGPTVSSGLPVESGSASGDGEIPWSSTPTVGRLPSGGESLEGSASASGTGDLSGLPSG GEITETSASGTEEISGLPSGGDDLETSTSGIDGASVLPTGRGGLETSASGVEDLSGLPSGEEGSETSTSG IEDISVLPTGESPETSASGVGDLSGLPSGGESLETSASGVEDVTQLPTERGGLETSASGIEDITVLPTGR ENLETSASGVEDVSGLPSGKEGLETSASGIEDISVFPTEAEGLETSASGGYVSGIPSGEDGTETSTSGVE GVSGLPSGGEGLETSASGVEDLGLPTRDSLETSASGVDVTGYPSGREDTETSVPGVGDDLSGLPSGQEGL ETSASGAEDLGGLPSGKEDLVGSASGALDFGKLPSGTLGSGQTPEASGLPSGFSGEYSGVDIGSGPSSGL PDFSGLPSGFPTVSLVDSTLVEVITATTASELEGRGTISVSGSGEESGPPLSELDSSADISGLPSGTELS GQTSGSLDVSGETSGFFDVSGQPFGSSGTGEGTSGIPEVSGQPSGSPDTTEISELSGLSSGQPDVSGEGS GILFGSGQSSGITSVSGETSGISDLSGQPSGFPVLSGTTPGTPDLASGAMSGSGDSSGITFVDTSLIEVT PTTFREEEGLGSVELSGLPSGETDLSGTSGMVDVSGQSSGAIDSSGLISPTPEFSGLPSGVAEVSGEVSG VETGSSLSSGAFDGSGLVSGFPTVSLVDRTLVESITLAPTAQEAGEGPSSILEFSGAHSGTPDISGDLSG SLDQSTWQPGWTEASTEPPSSPYFSGDFSSTTDASGESITAPTGSGETSGLPEVTLITSELVEGVTEPTV SQELGHGPSMTYTPRLFEASGEASASGDLGGPVTIFPGSGVEASVPEGSSDPSAYPEAGVGVSAAPEASS QLSEFPDLHGITSASRETDLEMTTPGTEVSSNPWTFQEGTREGSAAPEVSGESSTTSDIDAGTSGVPFAT PMTSGDRTEISGEWSDHTSEVNVTVSTTVPESRWAQSTQHPTETLQEIGSPNPSYSGEETQTAETAKSLT DTPTLASPEGSGETESTAADIDECLSSPCLNGATCVDALDTFTCLCLPSYRGDLCEIDQEQCEEGWTKFQ GHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRWSDGHSLQF EKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGEPPAVEHARTLGQKKDRYEI SSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPNTYKHRLQKRSMRPTRRSRPSMAH >XP_024837356.1 aggrecan core protein isoform X1 [Bos taurus] MTTLLLVFVTLRVITAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNMRSNDSGIYRCEVMHGIE DSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPESFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGSVILTAKPDFEVSPTAPEPEEPFTF VPEVRATAFPEVENRTEEATRPWAFPRESTPGLGAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFH YRPGSSRYSLTFEEAKQACLRTGAIIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDK CYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPEEEEGSAP TAGPDVEEWMVTQVGPGVAAVPIGEETTAIPGFTVEPENKTEWELAYTPAGTLPLPGIPPTWPPTGEATE EHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELFPSEKPFPSEKPFPSEEPFPSEKPFPPE ELFPSEKPIPSEEPFPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPVP SRTELPSSGEVSGVPEISGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLP SGEEERITWTSAPKVDRLPSGGEGPEVSGVEDISGLPSGGEVHLEISASGVEDISGLPSGGEVHLEISAS GVEDLSRIPSGEGPEISASGVEDISGLPSGEEGHLEISASGVEDLSGIPSGEGPEVSASGVEDLIGLPSG EGPEVSASGVEDLSRLPSGEGPEVSASGVEDLSGLPSGEGPEVSVSGVEDLSRLPSGEGPEVSASGVEDL SRLPSGEGPEISVSGVEDISILPSGEGPEVSASGVEDLSVLPSGEGHLEISTSGVEDLSVLPSGEGHLEI SASGVEDISRLPSGEGPEVSASGVEDLSVLPSGEDHLEISASGVEDLGVLPSGEDHLEISASGVEDISRL PSGEGPEVSASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGGEDHLETSASGVGDLSGLPSGREGLEIS ASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLESGPSSGLPDF SGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQA SGSPDISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQPSGFYGEISGVTELSGLASGQPEISGEASGI LSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAVSGSGESSGITFVDTSLVEVTPT TFKEEEGLGSVELSGLPSGEVGVSGTSGLADVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASGAE SGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSL DQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQ ELGQRPPVTYTPQLFESSGEASASGDVPRFPGSGVEVSSVPESSGETSAYPEAEVGASAAPEASGGASGS PNLSETTSTFHEADLEGTSGLGVSGSPSAFPEGPTEGLATPEVSGESTTAFDVSVEASGSPSATPLASGD RTDTSGDLSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTDASIPA SAGGTDDSEATTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRH FPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPN QPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRY QCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSHPSTAH >XP_015147464.2 aggrecan core protein isoform X1 [Gallus gallus] MTTLLLVFVCLQAITTAASAELSDSSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDTNALLTPRIK WSKLSNGTEIVLLVATGGKIRLNAEYREVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQD TIEVLVKGVVFHYRAISTRYTLNFERAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIH LPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTG ELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPANQTGYPHPSSRYDAICYSGDD FEALVPGLFTDEVGTELGSAFTIQTVTQTEVELPLPRNVTEEEARGSIATLEPMEITATATELYEAFTVL PDLFATSVTVETASPREENVTREEITGIWAVPEEVTTSVSGTAFTTGMAEVSSVEEAIAVTATPGLESAS PFTIEDHLVQVTAAPDVALLPRQPISPTGVVFHYRAATSRYAFSFIQAQQACLENNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPEQ FTFQEAQLYCESQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVSPRPACGGDAPGVRTIYQHHN QTGFPDPLSRHHAFCFRALPSVVEEGVTSLFEEEVMVTQLIPGVEGIPSGEETTVETELSSEPENQTAQG TEVFPTDVSLLSARPSAFPPATVIPEETSTNASIPEVSGEFPESGEHPTSGEPSASGAPDTSGEPTSVGF ELSGEQSGIGESGLPSVDLQSSGFVPGESGLPSGDVSGLPSGIVDISGLPSAEEEVTVSVSRIPEVSGMP SGAESSGLHSGFSGEISGTELISGLPSGEESGLASGFPTISLVDSTLVEVVTAAPGRQEEGKGSIGVSGE EELSGFPSAEWDSSGARGLPSGAETSGEQSGVPELSGEHSGVPGLSGEPFEVPELSGEHSGVTELSGEHS GLPELSGEPFGVPELSGFPSGLDISGEPSGAPEVSGPVDVSGLTSGVDGSGEVSGVTFISTSLQEVTTPS VAEAEAKEILEISGLPSGETSGMVSGSLDVSGQPSGHIDFGGSASGVLEMSGFPSGAVESSGEASGVEVT SGLASGEESGLTSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGFLSGDRGVSGDGSGAVQSSG LPSGTGDFSGEPSGIPYFSGDISGATDLSGQPSAVTDISGEDSGLPEVTLVTSDLVEVVTRPTVSQELGG ETAVTFPYVFGPSGEGSASGDLSGGASAEGGIETSTAYEISGESSAFPETSIETSTDQEISGEASAYPEI SVETSTHLETSGETSAYPEISTETSTIQEVSGETSAFPEISTETSTIQEISGETSAFPEIRIETSTFQEI SGETSAFPEIRIETSTSQEARGETSAFPEITIEASTVHETSGETSAFPEISIETSTVHETSGETSAFPEI SIETSTVHEISGESSAFPEIRIETSTSQEARGETSAFPEITIEASTIQEISGETSAFPEISIATSTVREI SGETSAFPEIRIETSTSQEARGETSALPEITIETSTVHETSGEASAFPEISIETSTRQEARGEASAYPEV SIEASTTQEVSGESSAFPEISVETSTSQEARGETSAFPEIGIETSTAHEGSGETPGLPAVSTDTAATSLA SGEPSGAPEKETPDTTSHLITGVSGETSVPDAVISTSAPDVELAQEPRNTEETQLEIEPSTPAASGQETE TAAVLDNPHLPATATAALHPASQEAVDALGPTTEDTDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLC EIDLANCEEGWIKFQGHCYRHFEERETWMDAESRCREHQAHLSSIITPEEQEFVNSHAQDYQWIGLSDRA VENDFRWSDGHSLQFENWRPNQPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVV ENARTFGRKKDRYEINSLVRYQCDHGYIQRHVPTIRCQPNGHWEEPRISCTNPSSYQRRLYKRSPRSRLR PGVVHRPTH >XP_020953956.1 aggrecan core protein isoform X1 [Sus scrofa] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPQPSPLRVLLGGSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRVSKEKEVVLLVATEGQVRVNSAYQDRVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGTVILTVKPVFEFSPTAPEPEEPFTF APGTGATAFPEAENRTGEATRPWAFPEESTPGLGAPTAFTSEDLVVQVTMAPGATEFPGQPRLPGGVVFH YRPGSSRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS TPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLASTGQLYAAWSRGLDK CYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAVAPSPGEEEGGT PTSLPDLEERIATQVGPGVAAVPVGEETTEVAAFTTEPENRTEWEFVYTPVGTSPLPGIPPTWPPTSAAT EEGTEGPSATEAPSTSEEPFPSEKPFPSEEPFPSEEPFPSEKPSASEEPFPSEQPSTLSAPVPSRTELPG SGEVSGAPEVSGDFTGSGEVSGHLDYSGQPSGEIASGLPSEDLDSSGLTSAVGSGLPVESGLASGDEDKI TWSSTSKVDRLPSGGEGPEGSVSGVEDLSGLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDLSRLP SGEGPEISASGIEDISQLPSGEGPEISASGIEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVE DISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEI SASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPS GEGPEISVSGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVED LSRLPSGEGPEISASGVEDLSRLPSGEGPDISASGVEDLSRLPSGEGPEISASGIEDLSRLPSGEGPEIS ASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSG EGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGVEDLSRLPSGGEGHLETSASGVE DLSGIPSGGEDHLESSASGVGDLSGLPSGREGLEIYASGAEDLSGLTSGKEDLAGSASGDLDVGRMPSGT LESGQAPEVSGLPSGFSGEYSGVDLGSGPSSGLPDFSELPSGFPTVSLVDTTLVEMVTATTASELEGRGT IGVSGAGETFGLPFSELDISGGASGHPSGAELSGQASGSPDISGETSGLFDVSGQPSGFPDISGGTSGLF EVSGQPSGFSGATSGVTELSGLSSGQPDISGDASGVLSGVGQPFGLTDVSGETSGVPDLSGQPSGWPGFS GMPSGTPDLVSSATSGSGESSGITFVDTSLVEVTPTTRKEEEGLGSVELSGLPSGEADLSGASGVVDVSG LASGATDSSGFTSQPPEFSGLPSGVTEVSGESSGVEIGSSLPSGAYDGSGLPLSAPTVYLVDRTLVESVT QAPTAQEAGEGPPGTLELSGAHSGVPDMSGDHSGSVDLSGLQSGLAEPSGEPASTPYFSGDFSVTTDISG DSSAATSTSGEASGLPEVTLIASEFVEGVTEPTVSQELGQRPPVTHTPQLFESSGEASASGDVPRFPGSG VEAPPIPESSRESSAYPEAETGASAAPEASGGASGSPDLTEATSAFHEADLEGTSGLGVSVSTSAFQEGT REVSAAPEVSRESTTTYDVGPEASGLPLATPVSSGDRTEVSGDLSGHTSGLEVAISTAIPEYAWTQQTQR PAEAPLEIESSSPVHSGEEMPTAKPATSQTEASIPTPPGQTDESEATTADFDECLSSPCLNGATCVDAID SFTCLCLPSYQGDLCEIDQKLCENGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVN NNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPF TCKKGTVACGEPPVVEHARIFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPAT YKRRLQKRSSRSLRRSRPSTGP >NP_001106926.3 aggrecan core protein precursor [Canis lupus familiaris] MTTLLLVFVTLRVITAASSLEASDPDNSLSVSIPEPSPMRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRITKEKEVVLLVATEGQVRINSAYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTVKPIFDLSPTAPEPEEPFTF VPEPEKPFTFATDVGVTAFPEAENRTGEATRPWGVPEESTPGPAFTAFTSEDHVVQVTAVPGAAEVPGQP RLPGGVVFHYRPGSARYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPR TPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDKLEGEVFFITRLEQFTFQEALAFCESHNATLASTGQLY AAWSQGLDKCYAGWLSDGSLRYPIVTPRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSAVPS PGEEEGGTPTPSVVEDWIATQVGPGVAAVPMGEETTAILDFTIEPENQTEWEPAYSPAGTSPLPGIPPTW PPTSTATEESTEGPSGTEVPSVSEEPSPSEEPFPWEELSTLSPPGPSGTELPGSGEASGVPEVSGDFTGS GEVSGHPDSSGQLSGESASGLPSEDLDSSGLTSAVGSGLASGDEDRITLSSIPKVEGEGLETSASGVEDL SGLPSGREGLETSTSGVGDLSGLPSGEGLEVSASGVEDLSGLPSGEGPETSASGVGDLSRLPSGEGPEVS ASGVGDLSGLPSGREGLETSTSGVEDLSGLPSGEGPEASTSGVGDLSRLPSGEGPEVSASGVEDLSGLPS GEGLEASASGVGDLSGLPSGEGPEASASGVGDLSRLPSGEGPEVSASGVEDLSGLSSGESPEASASGVGD LSGLPSGREGLETSASGVGDLSGLPSGEGQEASASGVEDLSRLPSGEGPEASASGVGELSGLPSGREGLE TSASGVGDLSGLPSGEGPEAFASGVEDLSILPSGEGPEASASGVGDLSGLPSGREGLETSTSGVGDLSGL PSGREGLETSTSGVGDLSGLPSGEGPEASASGIGDISGLPSGREGLETSSSGVEDHPETSASGVEDLSGL PSGVEGHPETSASGVEDLSELSSGGEGLETSASGAEDLSGLPSGKEDLIGSASGALDFGRIPSGTLGSGQ APEASSLPSGFSGEYSGVDFGSGPSSGLPDFSGLPSGFPTISLVDTTLVEVITTTSASELEGRGTIGISG AGETSGLPVSELDISGAVSGLPSGAELSGQASGSPDMSGETSGFFGVSGQPSGFPDISGGTSGLFEVSGQ PSGFSGETSGVTELSGLYSGQPDVSGEASGVPSGSGEPFGMTDLSGETSGVPDISGQPSGLPEFSGTTSG IPDLVSSTMSGSGESSGITFVDTSLVEVTPTTFKEEEGLGSVELSGLPSGEVDLSGASGTMDISGQSSGA TDSSGLTSQLPEFSGLPSGAAEVSGESSGAEIGSSLPSGTYEGSGLPSSFPTVSLVDRTLVESVTQAPTA QEAGEGPSGILELSGAHSGAPDVSGDHSGSLDLSGMQSGLVEPSGEPSSTPYFSGDFSGTMDVTGEPSTA MSASGEASGLLEVTLITSEFVEGVTEPTVSQELAQRPPVTHTPQLFESSGEASASGEISGATPAFPGSGL EASSVPESSSETSDFPERAVGVSAAPEASGGASGAPDVSEATSTFPEADVEGASGLGVSGGTSAFPEGPR EGSATPEVQEEPTTSYDVGREALGWPSATPTASGDRIEVSGDLSGHTSGLDVVISTSVPESEWIQQTQRP AEAHLEIEASSPLHSGEETQTAETATSPTDDASIPTSPSGTDESAPAIPDIDECLSSPCLNGATCVDAID SFTCLCLPSYRGDLCEIDQELCEEGWTKFQGHCYRYFPDRESWVDAESRCRAQQSHLSSIVTPEEQEFVN NNAQDYQWIGLNDRTIEGDFRWSDGHSLQFENWRPNQPDNFFVSGEDCVVMIWHEKGEWNDVPCNYYLPF TCKKGTVACGDPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEKPRITCTDPST YKRRLQKRSSRAPRRSRPSTAH >XP_027812861.1 aggrecan core protein isoform X1 [Ovis aries] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTF APEVRATAFPEVENRTGEATWPWAFPRESTPGVGAPTAFTSEDLVVQVTLAPGATEVPGQPRLPGGVVFH YRPGSSRYSLTFEEAKEACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGLRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDK CYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVVPSPGEEEGSTP TAGPEVEDWIVTEVGPGVAAVPVGEETTAVPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGEATE EHTEGPSATEVPSASEKPFPSEKPFPPEELFPSEKPFPSEKPFPSEKPFPSEKPFPSEKPFPPEELFPSE KPIPSEEPFPSEKPFPSEEPFPSEKPIPSEEPFPSEKPFRPEEPFPSEKPIPSEEPFPSEKPFPPEEPFP SEKPIPSEEPFPSEEPSTLSAPVPSRTELPTSGEASGVPEVSGDFTGSGEISGHLDFSGQPSGESASGLP SEDLDSSGLTPTVGSGLPVESGLPSGEEERITWTSPPIVDRLPSGGEGPEVSASGVEDISGLPSGGEVHL EISASGVEDLSRLPSGEGPEVSASGVEDLSGLPSGEEGHLEISASGVDLSGIPSGEGPEVSASGVEDLGV LPSGEGHLEISASGVEDLSRLPSGEGPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSGEGPEVSA SGVEDLSRLPSGEGPEVSASGVEDLSRLPSGGEVHLEISASGVEDLSRLPSGEGPEVSASGVEDLSGLPS GEEGHLEISASGVDLSGIPSGEGPEVSASGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSASGVE DLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSAPGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEV SASGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSASGVEDLGVLPS GEGHLEISASGVEDLSRLPSGEGPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSGGEDHLETSAS GVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASGLPSGFSG EYSGVDLGSGPSSGLPDFSGLPSGLPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELD ISGGASGLSSGAELSGQASGSPEISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQPSGFSGEISGVTE LSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGVPDLVSSAVSGSG ESSGIMFVDTSLVEVTPTTFKEEEGLGSVELSGLPSGEAGLSGTSGLVDVSGLSSGAIDSSGFTPQPPEF SGLPSGVTEVSGEASGAASGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILEL SGTPSGAPDMSGDHLGSLDQSGLQSGLVEPRGEPASTPYFSGDFSGATDVSGESSAATSTSGEPSGLPEV TLITSELVEGVTEPTVSQELGQRPPVTYTPKLFESSGEASVSGDVPSFPGSGVEASPVPESSGETSAYPE AEVGASAAPEASGGASGSPNLSETTSTFHEADLEGTSGLGASGRPSAFPEGPTEGLATPEVSGESTTAFD VSVEASGSPSATPLASGDRTDTSGDLSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGE ESQTADTATSPTDASIPTSTGGTDDSEATTTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEID QKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEG DFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHA RIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSRP STAH >XP_003952775.3 LOW QUALITY PROTEIN: aggrecan core protein [Pan troglodytes] MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFPEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYS LTFEEAQQACLHTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGV RPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADG SLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEW IATQVVPGVAAVPVEEETTAVPSGETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEE STEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEE PYTPSPPVPSWTELPSSGEESGAPDVSGDFIGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGS VLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGE VLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDIS GLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPG VEXISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVL ETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGL PSGEVLETTASGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTASGVEEISGLPSGEVLETSTSAV GDVSGPPSGGEVLEISASGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLSRLPSGEEV LEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDL DLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTAST ASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPD TSGETSGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPD LVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVNS SGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEA GEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDFASTTNVSRESSVAMGT SGEASGLPEVTLITSEFVEGVTEPTVSQELGQRPPVTHTPQLFESSGDVSTAGDVSGATPVLPGSGVEVS SVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTFQEGEASAA PEVSGESTTTNDVGTEAPGLPSATPTASGDRTEISGDPSGHTLRLGVVISTSIPESEWTQQTQRPAETHL EIESSSLLYSGEETHTVKTATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLC PPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDY QWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGT VACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQ KRSSRHPRRSRPSTAH >XP_008249943.1 PREDICTED: aggrecan core protein isoform X1 [Oryctolagus cuniculus] MTTLLLVLVALRVIAAAISGDVSDLDNALSVSIPQPSPVRALLGTSLTIPCYFIDPVHPVTTAPSTAPLT PRIKWSRISKDKEVVLLVANEGRVRINSAYQDKVSLPNYPAIPSDATLEIQSLRSNDSGIYRCEVMHGLE DSEATLEVVVKGVVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAASECRRLGARL ATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFMDIPENFFGVGGEEDITVQTVTWPDVELPVPRNITEGEARGSVVLTAKPVLDVSPTAPQPEETFAP GVGATAFPGVENGTEEATRPRGFADEATLGPSSATAFTSADLVVQVTAAPGVAEVPGQPRLPGGVVFHYR PGPTRYSLTFEEAQQACLRTGAAMASAEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSP GVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFQEALEFCESHNATLASTGQLYAAWSRGLDRCY AGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGTSEAPSPGPEEGGTATP ASGLEDWIVTQVGPGVAATPRAEERTAVPSFATEPGNQTGWEAASSPVGTSLLPGIPPTWPPTGTAAEGT TEGLSTAAMPSASEGPYTPSSLVARETELPGLGVTSVPPDISGDLTSSGEASGLFGPTGQPLGGSASGLP SGELDSGSLTPTVGSGLPIGSGLASGDEDRIQWSSSTEVGGVTSGAEIPETSASGVGTDLSGLPSGAEIP ETFASGVGTDLSGLPSGAEIPETFASGVGTDLSGLPSGAEILETSASGVGTDLSGLPSGAEILETSASGV GTDLSGLPSGAEILETSASGVGTDLSGLPSGAEIPETFASGVGTDLSGLPSGAEILETSASGVGTDLSGL PSGAEIPETSASGVGTDLSGLPSGAEILETSASGVGTDLSGLPSGAEILETSASGVGTDLSGLPSGAEIL ETSASGVGTDLSGLPSGAEILETSASGVGTDLSGLPSGAEILETSASGVGTDLSGLPSGGEIPETFASGV GDLSGLPPGREDLETLTSGVGDLSGLSSGKDGLVGSASGALDFGGTLGSGQIPETSGLPSGYSGEYSEVD LGSGPSSGLPDFSGLPSGFPTVSLVDTPLVEVVTATTARELEGRGTIGISGAGEISGLPSSELDVSGGTS GADISGEADVGGEASGLIVRGQPSGFPDTSGEAFGVTEVSGLSSGQPDLSGEASGVLFGSGPPFGITDLS GEPSGQPSGLPEFSGTTHRIPDLVSGATSGSGESSGIAFVDTSVVEVTPTTLREEEGLGSVEFSGFPSGE TGLSGTPETIDVSGQSSGTIDSSGFTSLAPEVSGSPSGVAEVSGEASGTEITSGLPSGVFDSSGLPSGFP TVSLVDRTLVESVTQAPTAQEAEGPSDILELSGVHSGLPDVSGAHSGFLDPSGLQSGLVEPSGEPPRTPY FSGDFPSTPDVSGEASAATSSSGDISGLPEVTLVTSEFMEGVTRPTVSQELGQGPPMTHVPKLFESSGEA LASGDTSGAAPAFPGSGLEASSVPESHGETSAYAEPGTKAAAAPDASGEASGSPDSGEITSVFREAAGEG ASGLEVSSSSLASQQGPREGSASPEVSGESTTSYEIGTETSGLPLATPAASEDRAEVSGDLSGRTPVPVD VVTNVPEAEWIQHSQRPAEMWPETKSSSPSYSGEDTAGTAASPASADTPGEPGPTTAAPRSCAEEPCGPG TCQETEGRVTCLCPPGHTGEYCDIDIDECLSSPCVNGATCVDASDSFTCLCLPSYGGDLCETDQEVCEEG WTKFQGHCYRHFPDRETWVDAEGRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDG HPLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVEHARTFGQKK DRYEINSLVRYQCAEGFTQRHVPTIRCQPSGHWEEPRITCTHPTTYKRRVQKRSSRTLQRSQASSAP >XP_024088629.1 LOW QUALITY PROTEIN: aggrecan core protein [Pongo abelii] MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRVSKEKEVVLLVATEGRVRVNSAYQEKVSLPNYPAIPSDATLEIQSLRSNDSGVYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDKAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFPEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYS LTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGV RPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADG SLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEW IATQVVPGVAAVPVEEETTAVPLGETTAILEFTTEPENQTEREPVYIPVGTSPLPGILPTWPPTGAATEE STEGPSATEVPSASEKPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEE PYTPSPPVPSWTELLSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGERASGLPSGDLDSSGLTSTVAS GLPVESGLASGDEERIEWSSTPTVGELPSGAEILEGSISGVGDLSGLPSGEVLETTAPGVEDISGLPSGE VLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTXPGVEDISGLPSGEVLETTXPGVEDIS GLPSGEVLETTXPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAP GVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEV LETXCPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVGDLSG LPSGEVLETSTSGVGDLSGLPSGEVLETSTSAVGDLSGLPSGGEVLETSASGVEDISGLPSGEVVETSAS GIEDVSELPSGEGLETSASGVGDLSRLPSGEEVLETSASGVRDISGLPSGGEVLEISASGVGDLSGLPSG VEGLETSASEVGTDLSGLPSGREGLETSASGTEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPE TSGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGE ISGLPSSELDISGGASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGETSGVTELSGLSSG QPGVSGEASGVLYGTSQPFGITDLSGETSGVSDLSGQPSGLPGFSGATSRVPDLVSGATSGSGESSGITF VDTSLVEVTPATFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGI AEVSGEASGAEIGSSLASGAYYGSGLPSGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILEISGAHSGA PDMSGDHSGFLDLSGLQSGLVEPSGEPPGTPYFSRDFASTTDVSGESSAAMGTSREASGLPEVTLITSEF VEGVTEPTVSQELGQRPPVTHTPQLFESSGEVSAAGDISGATPVLPGSGVEVSSVPESSNETSTHPEAGV GASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTFQEGKASAAPEVSGESTTTNDVGTKA PGLPSATPTASADRTEISGDLSGHTSGLGIVISTSIPESEWTQQTQRPVEAHLEIESSSLLYSGEETHTV QTATSPTDASIPTSPEWKRESESTAAAPARSCAEEPCGAGTCKETEGHVICLCPPGYTGEHCNIDQEVCE EGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWS DGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQ KKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_019475050.1 aggrecan core protein [Meleagris gallopavo] MTTLLLVFVCLQAITTAASAEFSESSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDTSALLTPRIK WSKLSNETEIVLLVATGGKIRLNAEYKEVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQD TIEVLVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIH LPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTG ELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPINQTGYPHPSSRYDAICYSGDD FEALIPGQFTDEVGTELGSAFTIQTVTQTEVELPLPRNATEEEARGSIATLEPMEITATATELYEAFTVL PDLFTTSVTVETASPGEENVTREEVTGIWAVPEEVTTSVSDTAFTTEMAEVSSVEVAIGVTATPELESAS PFTVEDHLVQVTAAPDVALLPRQPISPTGVVFHYRAATSRYALSFVQAQWACLENNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPER FTFQEAQLYCASQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVSPRPGCGGDAPGVRTIYQHYN QTGFPDPLSRHHAFCFRALPSVEEEGVTSHFEEEVMVTQVIPGVEGIPSGEETTVETELSAEPENQTAWG TEVIPTDVSLLSARPSAFPPATVIPEETSTSASIPEVSGEFPESGEHPASGEPSASGAPDTSGEPTSGGF ELSGEHSGIGESGLPSVDLQSSGFVPGESGLPSGDVSGLPSGTVDTSGLPSAEEEISVSISRIPEVSGMP SGAESSGLHSGFSGEISGTELISGLPSGEESGLTSGFPTVSLVDSTLVEVVTAAPGRQEEGKGSIGVSGE GELSGFPSAEWDSSGARGLPSGAEASGEHSGVPELSGEHSGVPGLSGEPFEVPELSGEHSGVPELSGEHS GLPELSGEPLGVPELSGFPSGLDISGEPSGIPEVSGLVDVSGLTSGVDGSGEISGITFISTSLQEVTTPS TAEAEAKEILEISGLPSGETSGMVSGSLEVSGQPSGHIDFGGSASGVLEMSGFPSGAVESSGETSGVEVT SGLASGEESGLPSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGFLSGDRGLSGEGSGAVQSSG LPSGTGDFSGEPSGIPYFSGDISGATDLSGQPSAVTDISGEDSGLPEVTLVTSDLVEVVTRPTVSQELGG ETAVTFPYIFGPNGEGSASGDLSGGTSAEGGIETSTAYEISGETSAFPETSIETSTGQEISGEASAYPEI SVETSTNLETSGETSAYPEISTETSTIQEVSGETSAFPEISTETSTIQEISGETSAFPEIRIETSTFQEI SGETSAFPEIRIETSTSQEARSETSAFPEITIEASTVHETSGETSAFPEISIETSTVHEISGESSAFPEI RIETSTSQEARGETSAFPEITIEASTIQEISGETSAFPEISIETSTVREISGETSAFPEIRIETSTSQEA RGETSAFPEITIETSTVHETSGETSAFPEISIETSTQEARGEGSAYPEVSIEASTIQEVSGESSAFPEIS VETSTSQEARGETSAFPEIGIETSTAHESSGETPGLPAVSTDTAATSLASGEPSSAPEKEIPDATSHLIA GVSGETSVPDVVISTSAPDVELTQEPRNTEETRLEIEPSTPAASGQETETAAVLDSPHLPATATAALHPA SQEAIDALGPTTEDTDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLCEIDLANCEEGWIKFQGHCYRH FEERETWMDAESRCREHQAHLSSIITPEEQEFVNSHAQDYQWIGLSDRAVENDFRWSDGHSLQFENWRPN QPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSLVRY QCDHGYIQRHVPTIRCQPNGHWEEPRISCINPSSYQRRLYKRSPWSRSRPGVMHRPTH >XP_034795266.1 aggrecan core protein isoform X1 [Pan paniscus] MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFPEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYS LTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGV RPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDECYAGWLADG SLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEW IATQVVPGVAAVPVEEETTAVPSRETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEE STEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVELFPSEEPFPSKEPSPSEEPSALEEPYTPSP PVPSWTELPSSGEESGAPDVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLISTVGSGLPVES GLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSASGVGDLSGLPSGEVLETTA PGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGE VLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEEIS GLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEDISGLPSGEVLETTAP GVEDISGLPSGEVLETTASGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEEISGLPSGEV LETSTSAAGDLSGLPSGGEVLEISASGVEDISGLPSGEVVETSASGIEDVSELPSGEGLETSASGVEDLS RLPSGEEVLEISASGFGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSVLPSGKEDL VGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTL VEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVS GQPSGFPDTSGETSGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFS GATSGVPDLVSGTTSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSG QFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVT QAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDFASTTNVSG ESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTVSQELGQRPPVTHTPQLFESSGEVSTAGDVSGATPVL PGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTF QEGEASAAPEVSGESTTTNDVGTEAPGLPSATPTASGDRTEISGDLSGHTSRLGVVISTSIPESQWTQQT QRPAETHLEIESSSLLYSGEETHTVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPCGAGTCKET EGHVICLCPPGYTGEHCNIDIDECLSSPCLNGATCVDAIDSFTCLCLPSYEGDLCEIDQEVCEEGWNKYQ GHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQF ENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEI NSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_023110702.1 LOW QUALITY PROTEIN: aggrecan core protein [Felis catus] MTTLLLVFVTLRVITAASAIEASDPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLS PRIKWSRISKEKEVVLLVATEGQVRVNSAYQDKVSLPNYPAIPSDATLEIQNLCSNDSGMYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEDMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNVTEGEARGNVILTVKPIFDVSPTIPEPEEPFTF VPEVGATAFPEAENRTGEATRPWGVPEESTPGLAFTAFTSEDHVVQVTAVPGATEVPGRPRLPGGVVFHY RPGSARYALTFAEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSS PGVRTYGVRPPSETYDVYCYVDRLEGEVFFVTRPEQFTFEEALAFCESHNATLASTGQLYAAWSGGLDKC YAGWLSDGSLRYPIVTPRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSAAPSPGEEEGGTAT PSVEDWIATQVVPGVAAVPSGEETTTSPDFTTEPENQTEWELAYTPVGTSPPPGIPPTWPPTSAATEEST EGPSGTEVPSASEEPSPSEEPAPSEEPFPWEEPSTLAPPVPSGTELPGSGEASGVPEVSGDFTGSGEVSG RLDSSGQPSGEISSGLPSGDLDSSGLTSAVGSGLPVESGLASGDEDRITGPSIPKVGGEGLETSASGVGD LSGLPSAEGPEVSASGVEVLSGLPSGEGPEVSASGVGDLSGLPSAEGPEVSASGVEVLSGLPSGEGPEVS ASGVEVLSGLPSAEGPEVSASGVEVLSGLPSGEGPEVSASGVGDLSGLPSAEGPEVSCLWSRVLSGLPSG EGPEVSASGVEVLSGLPSAEGPEVSASGVGDLSGLPSAEGPEVSASGVEVLSGLPSGEGPEVSASGVEVL SGLPSGEGPEVSASGVEVLSGLPSAEGPEVSASGVEVLSGLPSAEGPEVSASGVEVLSGLLLEKKSLASG VGDLSGLPSAEGPESLASGVEVSAGCFCRRSEVSASGVGDLSGLPSGEGPEVSASGVEVLSGLPSGEGPE VSASGVEVLSGLPSGEGPEVSASGIGDLSGLPSGREGLETSASGVGGLSGLPSGIEGHPETSASGVGDLS EFYSGGEGLETSASGAEELSGLPSGKEDLIGSASGDLDLGRIPSGTPGSGQAPEASGLPSGFSGEYSGVD LGSGPSSGLPDFSGLPSGFPTISLVDTTLVEVVTATTASELEGRGTIGISGAGETSGLPLSELDISGAVS GLPSGAELSGQASGSPDTSGETSGFFGVSGQPSGFPDISGGTSGLFEVSGQASGFSGETSAVTELSGLVS GQPDVSGEASGVLSGSGQPFGITDLSGETSGVPGVSGATSGIPDLVPSAVSGSGASSGITFVDTSLVEVT PTTFKEEEGLGSVELSGLPSGEAGLSGTSGIMDVSGQSSGAVDSGGFTSPPPEFSGLPSAVAEVSGESSG AEIGSSLPSGAYDGSGLASGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGIVELSGAHSGAPDVSGDHSG FLDLSGPRSGLVEPSGEPSSTPYFSGDFSGTVDVSGESSAATGTGGEASGLPEVTLITSEFVEGVTEPTV SQELAQRPPVTHTPRLFESSGEASASGEISGATPTFPGSGVGSVPESSSETPAFPEAGVGASAAPEASGG ASGSPDVSEATSTFPDADVEGGSGLAVSGSTSAFPEGPGEGLATPEAREEPTTTHDVGTEASGWASATPM ASGDRTEIGGDLSGHTSGLDVVISTSVPESEWTQQTQRPAEAHLEIESSSPLHSGEETQTAETATFPTDA SIPTPPGGTDESAVTVADIDECLSSPCLNGATCVDAIDSFTCLCLPSYRGDLCEIDQELCEEGWTKFQGH CYRYFPDRESWVDAESRCRAQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHSLQFEN WRPNQPDNFFVSGEDCVVMIWHEKGEWNDVPCNYYLPFTCKKGTVACGDPPVVEHARTFGQKKDRYEINS LVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPSTYKRRLQKRSSRPARRSRPSTAH >XP_018865821.2 LOW QUALITY PROTEIN: aggrecan core protein [Gorilla gorilla gorilla] MTTLLWVFVTLRVITAAVTVETSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPTDATLEIQSLRSNDSGVYRCEVMHGIE DSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTF APEIGATAFPEVENETGEATRPWGFPTPGLGPATAFTSEDLVVQVTAVPGQPHLPGGVVFHYRPGPTRYS LTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKNSSPGVRTYGV RPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADG SLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISVVPSPGEEEGGTPTSPSGVEEW IATQVVPGVAAVPAEEETTAVPSRETTAILEFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEE STEGPSATEVPSASEEPSPSEVPFPSEEPSPSEEPFPSVRPFPSVELFPSEEPFPSKEPSPSEEPSASEE PYTPLPPVPSWTELPSSGEESGAPDVSGDFIGSGDVSGHLDFSGQLSGDRASELPSGDLDSSGLTSTVGS GLPVESGLASGDEERIEWSSTPTVGELPSGAEILEGSASGVGDLSGLPSGEVLETSAFGVEEISGLPSGE VLETTAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEEIS GLPSGEVLETTXPGVEEISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEEISGLPSGEVLETTAP GVEEISGLPSGEVLETXAPGVEEISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEV LETTAPGVEEISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGVEDISR LPSGEVLETSTSAVGDLSGLPSGGEVLEISASGVEDISISGLPSGEVVETSASGIEDVSELPSGEGLETS ASGVEDLSRLPSGEEVLEISASGVGDLSGLPSGGEGLETSASEVGTDLSGLPSGREGLETSASGAEDLSG LPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSDLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPT VSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGE IPGLFGVSGQPSGFPDTSGETSGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITGLSGETSGVPDLSGQ PSGLPGFSGATSGVPDLVSGATSGSGESSGITFVDTSLVEVAPTTFKEEEGLGSVELSGLPSGEADLSGK PGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAETGSSLPSGAYYGSGTPSSFPTVSLVD RTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDF ASTTNVSGESSVAMGTSGEASGLPEVTLITSEFVEGVTEPTISQELGQRPPVTHTPQLFESSGEVSTAGD VSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHKADLERSSGLG VSGSTLTFQEGEASAAPEVSGESTTTNDMGTEAPGLPSATPTASGDRTEISGDLSGHSSRLGVVISTSIP ESEWTQQTQRPAETHLEIESSSLLNSGEETHKVETATSPTDASIPASPEWKRESESTAAAPARSCAEEPC GAGTCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSI VTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWN DVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEE PRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_021145604.1 aggrecan core protein isoform X1 [Columba livia] MTTLLLVFVCLRIIAAAVAVELSDSSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDTSALLTPRIK WSKLSNGTEVVLLVATGGKIRLNSEYREVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQD TIEVLVKGIVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIH WPRVQCYGDKDEFPGVRTYGVREPDETYDVYCYAEQMQGKVFYASAPEKFTFQEAFDKCHSLGARLATTG ELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLHANQTGYPHPDSRYDAICYSGDDV ETLVPGQFIDERGSELGSAFTIQTVTQTEVELPLPRNATEEEARGSIATLEPIEITPPATELYEGFTVLP DLFATGVTAETAAPEEENVTRGDVTEVWAVPEEVTTVTLGTLITTQTAEMSSVEEVMEVTATPGLESASV FTVEDQLVRVTAAPGVGLLPEQPISPTGVVFHYRSATSRYAFSFVQAQQACLENNAVIATPEQLQAAYEA GFDQCDAGWLRDQTVRYPIVNPRSNCVGDKENSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPEQF TFPEAQQYCESQNATLASVGQLHAAWKQGLDRCYAGWLADGSLRYPIVSPRPACGGDAPGVRTIYQHYNQ TGFPDPLSRHHAFCFRALPPVEEDGVTLFFEEDALATQVIPGVEGVPSGEEVTVETEFATQPENQTAWGT EVLPTDVSLLPVSPSVFPPATIIPEETSTNASISEVSGEMTESGEHQVSGETSASGWVPEVPDASGEPTS GLFELSGEHSGIGESGLPSVDLHTSGFLPGESGLPSGDLSGVPSGIVDISGLTSGEEDVSVSTSRTPEVS GLPPGVESSGLPSGFSGEISGTELVSGVSSGEESGLASGFPTISLVDTTLEEVVTTVPERQEEGKGSIGV SGEGDLSGFPSAEWDTSEGTHGLPSGAELSGEPSREPELSGEPSGVPELSGLPSGLDVSGEPSGTHEVSG LVDLSGLTSGIDGSGEALGVTFVDTSLEEVTTIPSITRAEAKEILEISGLPSGGGDTSGMVSGSSDISGE PSGHVDFGGSASGVLEMSGHPSGVIDSSGEVSGVDVTSGLLSGEESGLTSGFPTVSLVDTTLVEVVTQTS VAQEVGEGPSGMIEISGFPSGDRGLSGEASGAILTSGFPSGTGDFSGEPSGIPYISGDTSGTTDLSGQSS AVTDASGEASGLPEVTLVTSDLVQVVTIPTVSQELGGETAVTFPYGFGPSGGASASGELSGETSAWPESG METSTAYEISGEASAFPETSIETSTIQEISGETSAFPETSVETSTIHEISGETSAFPEFSTETSTIQEIS GETSAFPEIIIETSTSQEARGETSGYPEIIIETSTIQEISGETSGFPESSTETSTTQEISGETSAFPEIR IETSTVQEISGETSAFPEIRIETFTSQEARAETSGYPEISIETSTVHETSGESSAFPEIIIETSTVHEIS GESSAFPEISIETSTVREISGESSAFPEISIETSTVREISGESSAFPEIRIETSTNQEARGETSAYPEIS IETSTVHETSGETSAFPQISIETSMVHEISGETSAFPEIRIETSTSQEARGETSAFPEINIETSTVHEIS GEASAFPEINIETQTSQEARGETFVYPETSIETSTVQEVSGETSAFPEIRIETSTVQEVSGETSAFPEIR IETSTSQEARGETPAFSDTNRETSTVHKTSGEASSLPASNVETAATSLARGEPSGAPEEKEIPDTTSGAV THSITGVSGEASVPDFVISTSTPDVEPTQGHRNPEEAQLEIEPSPPAVSEQQTETDAVLDNPHLLATATA VLPQVSQEAIDALGPTTEDTDECHSSPCLNGATCADGIDSFKCLCLPSYGGDLCEIDLQNCEEGWTKFQG HCYRHFEDRETWMDAENRCRQYQAHLSSIITPEEQDFVNSHAQDYQWIGLSDRAVENDFRWSDGHSLQFE NWRPNQPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEIN SLVRYQCNQGYIQRHVPTIRCQPNGQWEDPRISCINPSNYQRRLYKRSPRSRSRLSGRAVHRPTH >XP_017922102.1 PREDICTED: aggrecan core protein [Capra hircus] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEREEPFTF APEVRATAFPAVENRTGEATWPWAFPRESTPGVGAPTAFTSEDLVVQVTLAPGVTEVPGQPRLPGGVVFH YRPGSSRYSLTFEEAKEACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGLRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDK CYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPGEEEGSTP TAGPEVEDWIVTEVRPGVAAVPVGEETTAIPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGEATE EHTEGPSATEVPSASEKPFPSEEPFLPEEPFPSEKPFPPEELFPSEKPFPSEKPFPSEKPFPSEEPFPSE KPFPPEELFPSEKPIPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFP SEEPSTLSAPVPSRTELPTSGEASGVPEVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDFDSSGLTPT VGSGLPVESGLPSGEEERITWTSAPKVDRLPSRGEGPEVSASGVEDISGLPSGGEVHLEISASGVEDLSG LPSGEEGHLEISASGVEDLSGIPSGEGPEVSVSGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSA SGVEDLGVLPSGEGPEVSASGVEDLSRFPSGEGPEVSASGVEDLGVLPSGEGHLEISASGVEDLSRLPSG EGPEVSASGVEDLGVLPSGEGHLEISASGVEDLGVLPSGEGHLEISASGVEDLSRLPSGEGPEVSASGVE DLGVLPSGEGHLEISASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGEGHLEISASGVEDLGVLPSGEG HLEISASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGEGHLEISASGVEDLGVLPSGEGHLEISASGVE DLSRLPSGGEEHLETSASGVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVT LGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDLSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGT IDISGAGETSGLPFSELDISGEASGLSSGAELSGQASGSPEISGETSGLFGVSGQPSGFPDISGETSGLL EVSGQPSGFSGEISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFS GTTSGIPDLVSSAVSGSGESSGIMFVDTSLVEVTPTTFKEEEGLGSVELSGLPSGEAGLSGTSGLVDVSG LSSGAIDSSGFTPQPPEFSGLPSGVTEVSGEASGAASGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVT QAPTAQEAGEGPSGILELSGTPSGAPDMSGDHLGSLDQSGLQSGLVEPRGEPASTPYFSGDFSGATDVSG ESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQELGQRPPITYTPQLFESSGEASVSGDVPRFPGSG VEASPVPESSGETSAYPEAEVGASAAPEARGGASGSPNLSETTSTFHEADLEGTSGLGASGSPSAFPEGP TEGLATPEVSGESTTAFDVSVEASGSPSATPLASGDRTDTSGDLSGHTSGLDIVISTTIPESEWTQQTQR PAEARLEIESSSPVHSGEETQTADTATSSTDASIPTSTGGTDDSEATTTDIDECLSSPCLNGATCVDAID SFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVN NNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPF TCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPAT YKRRLQKRSSRPLRRSRPSTAH >XP_014377588.1 aggrecan core protein [Alligator sinensis] MTTLLLVIVYLRVITAAFSVELSDNGDGLEVRIPEQSPLKVVLGNSLIIPCYFSDPIDYDTISPLTPRIK WSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNYPAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQD TIEVIVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIH FPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTG ELYLAWKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYVNQTGYPHPHTRYDAICYTGEDF EGLVPENFTDETAGELGSAFTIQTVTRTEVELPLPHNVTEEEARGSIATLGPIDITPTASELYEGFTVTP GLFATGITAETAFTEAENVTEEEATPVWAIPEEVTTWALETFYTSEAPEVSSVEEALGVTATPELESASA FTVEEQIVQVTAAPDIALIPEQPISPTGVVFHYRPATNRYSLNFVQAQQACLDNNAVIATPEQLQAAYEA GFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGVRTYGMRPASEMYDVYCYIDRLKGEVFFATQPGQF TFQEAREYCESQNFTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVTPRAACGGDKPGVRTIYLNPNQ TGFPDPLSRHHAYCFRALPSLQEVEGATPFFEEDLIATQVIPGVEEVPSGEETTVETELATGPENQTEWG AEVFPTDISLLSVSPSVFPPVSAIPEETSAEASVSGVSGDISASGEPQISGEPTISGWVSGAPDVSGEPA SGIFEPSGEPSGIGESGMPSADLDISGLLSGESGLPSGDVSGMPPVIIDVSGLPSGEEDLAVSASGIPDI SGMPSGEEISELPEISGLPSGFSGEVSGVELTSGLPSGEESGLPSGIPTVYIDHTTLVEVVTTAAEREQE GKGVIGVSGEGDLSGLPSAEWDISGKISGFPSGADISGEPSGIPDISGAPSGIPDISGLPSGVDISGMPS GIPDISGLPSGIDISGAPSGIPDISGFVDLSGLVSGGDESGEPSGITFINASVVEVTTPSITEAEAKEIL EISGLPSGEEDISGAVSGILDVSGLPSGLVDFSGDVSGMPEISGLPSGIPDISGEISGVEVSSGQPSGVY DYSGLQSGLPTISLVDTTLVEVVTQTSVAQEAGEGPSGVLEISGLPSGERETSGEVSGMVDISGLPSGTV DISGEPSSVPYFSGDISGVTDLSGLTSAVTEVSGEESGLPEVTLITSDLEEVVTKPTVSQELGGETAVTV PHIFEASGDASASGESSAETSALPEISPETSTAYEISGETSAFPEAATESSTAREISGETSALPEISIET STVHETGGETSAFPEISIETSTVHETSGETSALPEIHIETATVQEASGETSALPEISIETATVGGTSGET SALPEISIETATVGGTSDETSALPEISIEAATVGETSDETSALPEISIEAATVGETSDETSALPEISIEA ATVGETSDETSALPEISIETATVGGTSDETSALPEISIEAATVGGTSDETSALPEISIEAATIGETSDET SALSEISIETATAGGTSDETSALPEISIETATVHETSSETSTFPETSTDTSGISLVSGESSGTPEERREI STDTSGTHTHTIPDISGETSAPDIVISTSIPDVELTQEPKGPEEAQLEIESSTPMVSGQETETAAVLETL LISPTATAILPQVSQEATDVPRLTAEVAPKTCDENPCGAGTCQERDGGITCLCPPGYMGDRCDIDLEDCE VGWTKFQGHCYRHFEERETWVDAETRCREHQAHLSSIITPEEQDFVNNHAQDYQWIGLSDRAVEHDFRWS DGNSLQYENWRPNQPDNFFATGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGR KKDRYEINSMVRYQCNQGFIQRHVPTIRCQPNGHWEEPRIACINPSTYQRRLYKRSSRNRSRTNGRAVQR PTH >XP_019333446.1 PREDICTED: aggrecan core protein isoform X1 [Alligator mississippiensis] MTTLLLVFVYLRVITAAFSVELSDNGDGLEVRIPEQSPLKVVLGNSLIIPCYFSDPIDYDTISPLTPRIK WSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNYPAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQD TIEVIVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIH FPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTG ELYLAWKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYVNQTGYPHPHTRYDAICYTGEDF EGLVPENFTDETAGELGSAFTIQTVTRTEVELPLPYNVTEEEARGSIATLGPIDITPTASELYEGFTVTP GLFATGITAETAFTEAENVTEEEATPVWAIPEEVTTWALETFYTSEAPEVSSVEEALGVTATPELESASA FTVEEQIVQVTAAPDIALIPEQPISPTGVVFHYRPATNRYSLNFVQAQQACLDNNAVIATPEQLQAAYEA GFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGIRTYGMRPASEMYDVYCYIDRLNGEVFFATQPGQF TFQEAQEYCESQNSTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVTPRAACGGDKPGVRTIYLNPNQ TGFPDPLSRHHAYCFRALPSLQEVEGATPFFEEDLIATQVIPGVEEVPSGEETTVETELATGPENQTEWG TEVFPTDISLLSVSPSVFPPVSAIPEETSAEASVSGVSGDISASGEPQISGEPTISGWVSGAPDVSGEPA SGIFEPSGEPSGIGESGMPSADLDISGLLSGESGLPSGDISGMPPVIIDVSGLPSGEEDLAVSASGIPDI SGMPSGEEISELPEISGLPSGFSGEVSGVELTSGLPSGEESGLPSGIPTVYIDHTTLVEVVTTAAEREQE GKGVIGVSGEGDLSGLPSAEWDISGKISGFPSGADISGEPSAIPDISGAPSGIPDISGLPSGVDISGMPS GIPDISGLPSGIDISGAPSGIPDISGFVDLSGLVSGGDESGEPSGITFINASVVEVTTPSITEAEAKEIL EISGLPSGEEDISGAVSGILDVSGLPSGLVDFSGDVSGMPEISGLPSGIPDISGEISGVEVSSGQPSGVY DYSGLQSGLPTISLVDTTLVEVVTQTSVTQEAGEGPSGVLEISGLPSGERETSGEVSGMVDISGLPSGTA DISGEPSSVPYFSGDISGVTDLSGLTSAVTEVSGEESGLPEVTLITSDLEEVVTKPTVSQELGGETAVTV PHIFEASGDASASGESSGETSALPEISPETSTAYEISGETSAFPEAATESSTAREISGETSALPEISIET STVHETSGETSAFPEISIETSTVHETSGETSALPEIHIETATVQEASGETSALPEISIETATVGGTSGEI SALPEISIETATVVETSDETSALPEISIEAATVGETSDETSALPEISIETATVGGTSDETSALPEISIET ATVGGTSDETSALPEISIETATVHETSSETSTLPEISIETATVHESSGETSTFPETTTDTSGISLVSGES SGTPEERREISTDTSGTHTHTIPDISGETSAPDIVISTSIPDVELTQEPKGPEEAQLEIESSTPMVSGQE TETAAVLETLLISPTATAILPQVSQEATDVPRLTAEVAPKTCDENPCGAGTCQERDGGITCLCPPGYMGD RCDIDIDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLCEIDLEDCEVGWTKFQGHCYRHFEERETWVD AETRCREHQAHLSSIITPEEQDFVNNHAQDYQWIGLSDRAVEHDFRWSDGNSLQYENWRPNQPDNFFATG EDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSMVRYQCNQGFIQR HVPTIRCQPNGHWEEPRIACINPSTYQRRLYKRSSRNRSRTNGRAVQRPTH >XP_020765043.1 aggrecan core protein [Odocoileus virginianus texanus] MTTLLLVFVTLRVIAAAISVEVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLA PRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIE DSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVR YPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARL ATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYT GEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPEFEVSPTVPEPEEPFTF VPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFH YRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDS SPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDK CYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVTPSPGEEEGSTP TAGPDVEDWIVTQVGPGVAAVPVGEETTATPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATE EHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELFPSEKPFPSEKPFPSEEPFPSEKPSEKP FPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVPEVSGDFTGSGEISGHLDLSGQPSGESASGLPSEDL DSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKIDRLPSGGEGPEVSASGVEDISGLPSGGEGHLEISA SGVEDLSRLPSGEGPEISASGVEDLSGLPSGGEVHLEISASGVEDLSRLPSGEGPEISASGVEDLSGLPS GEGPEVSVSGAEDLSGLPSGEGPEVSVSGAEDLSGLPSGEGPEVSVSGAEDLSGLPSGEGPEVSVSGAED LSGLPSGEGPEVSASGVEDLSRLPSGEVPEVSASGVEDFSRLPSGEGPEISASGVEDFSRLPSGEGPEVS ASGVEDLSRLPSGEGPEVSASGVEDLGILPSGEGHLEISASGVEDLSRLPSGGEDHLETSASGVGDLSGL PSGREGLEISASGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLG SGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGL SSGAELSGQASGSPDISGETSGFFGVSGQPSGFPDISGETSGLLELSGLPSGQPEISGEASGILSGLGPP FGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGVPDLVSSAMSGSGESSGITFVDTSLVEVTPTTFKEEEG LGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPS GAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQS GQVEPSGEPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITSELVEGVTEPTVSQELGQRPP VTYTPQLFESSGEASASGDVPRFPGSGIEASSVPESSGEMSAYPKAEVGASAAPEASGGASGSPDLSETT STFHEADLEGASGLGASGSSSAFPQGPTEGLATPEVSGESTTTFDVSVEASGSPSTTPLASGDKTDTSGD LSGHTSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTDASIPTSAGGTDD SETTTTDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGL NDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTAATYK RKLQKRSSQPLRRSRPSTAH >XP_040198337.1 aggrecan core protein isoform X1 [Rana temporaria] MTTLLLVFVCLRVIAAAISVEFSDHANTLSVSIPEEAPLNVLLGHSVTIPCYFINAVEHLTVAPSTAPLS PRIKWSRHNKGHETVLLVATNSQIRVTEAYKGRISLPNYPLIPTDVSLEIVNLLSSDSGVYRCEIMHGIE DSQDTVTLNVKGIVFHYRAISTRYTLDFENAKKACIQNNAVIATPEQLQSAYDDGYHQCDAGWLSDQTVR YPIHNPREPCYGDKEMFPGVRTYGVRETDETYDVYCYAEHMEGEVFYATSPGKYTFHEAEKQCQNLGARL ATTGELYLAWQTGMDVCSAGWLADRSVRYPISYKRPNCGGNLVGVRTVYLHPNQTGYPDPLSRYDAICYK DDAENITIQTVTQPGLELIFQRNVTEEEARGSIATLEGLDFTLTPSEDSFTATPVFPGTPLSPDLVPTEA PLENITDDGLQLWLENVTAVPSVEATGTVEGEVVPVTAAIDAAQPGKPISETGVVFHYRAGSSRYSLNFN QAKQACLNNHAAITTPAQLQAAYEAGFDQCDAGWISDQTVRYPIVQPRENCNGDKNGFPGVRNYGVVNPD EQYDVYCYIDKLRGQVFFATQPDHFTFQQAQEFCESKNATLASTGQLYSAWKSGFDKCRAGWLSDGSVRY PIVTPRKVCGGDQSGVRTVYLYANQTGFPDPLSKYNAFCFRPSLFEEEEEVPGTPSIEEEIIATKLYPVV EGLPSGEEITVETVTATEFENETDFWLLNATALPTVELEIVRPSAIPPVAAVPEDVSGEASVSGASGIPS GEVSGEPSGEVSGVPDISGEPSASGLVSGEGSGEPSGISGFSSGDISASGLPSGEVSGEIPSGEIDTSGL PSGFPSGDELISGSASGFPDISGLTSADMSGLPSGDVSGEASGVELVSGLPSGFESGLSSGDFSGLHSGD FSGLPSGDFSGLPSGFPTILHVDTVWTEGITKSPDTEAEGKGTTEFSASGDISGLPSTDFSGLASGLELS GEPSGLDFSGRPSGFFEVSGEVSGIDMSGFSSGIPLEESSGDISGISGLPSGISGEESGDISGAKEFSGD ISGIFSGDLSGISGSGLIDFSGEIDISGEISGASGDISGVSSGTFDESGESSGVTLIDGILVESTRPSEK EEEGKGSVEESGLFSGDFSGEISGISGISGEISGDIDASGLISGELPSGELDISGLTSGIIDISGEASGA GFISGLPSGIDDISGEASGAGFISGLPSGIDDISGEASGAGFISGLPSGIDDISGLTSGFPTISHIDLTL VEVPTIGPDTEEAGQGPSGVFEISGFPSGETSTEASGIIDLSGFPSGETSTEASGIIDLSGFPSGTQESG DGSGIHTSGIPDIKLITDDLIEAVTEPTVSQELAGVTSPYIIDASASGDISGEGPLTIPDISGEPSGIPL TSGEPESFVEGSTEASTDISGHQTSSANDVSGETSVPDIVISTSQPESEISLDQKEPEEAKKDTELSASA SGDITEDVPLEVVTPAPLLEAKPQAIPDVTEVEGIVGTCADINCGAGACVERDGRVHCQCLPGYGGDNCE IDIDECLPSPCVNGATCVDGIDSFKCLCLPSYGGDLCQIDIEVCDEGWTKFQGHCYQHFSNRETWVDAEN TCRSHQSHLSSILSSEEQEFVNGNAQDYQWIGLNDKTVENDFRWSDGNPLQYENWRPNQPDNFFATGEDC VVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVENAYTLGRTKERYEITSLVRYQCNQGFLQRHVP IIRCLSSGQWEEPRIQCINPSTYRHRRSPRRRPKSADKDTQKKAH >tr|F1R511|F1R511_DANRE Aggrecan b OS=Danio rerio OX=7955 GN=acanb PE=4 SV=3 GTSLYLICLENSTLSVSIPVEQPLRPLLGGSMVIPCYFQDITLQDPGTLTSPTNAPLSQR IKWSHIHKGKISLILVATEGQVQVETEYLDRVHLVNYPMVPSDATIEISELRSHDSGTYR CEVMQGIDDNYDSVEMQIQGIVFHYRAISTRYTLTFEMAKAACIQNSAVIATPAQLQAAY DDGFHQCDAGWLSDQTVRYPIHEPREPCYGDKDNFPGVRTYGVRDVNETYDVYCFAEKMS GRVFYSMSVEKFTFADAEDQCAKLGAQLATTGQLYLAWKTGMDVCNAGWLADRSVRYPIN IARPQCGGGLLGVRTVYLFPNQTGYPYPDSRYDAICYEEDKVLIKTTPFPEIYTTTDSSD YTEQVTTEGEVRGQILTDEPFNTTSTESPLSPPLNITDVEEDIINVATAPPSLEHAIPSI NVTAKIKGVVFHYRAESGRYAYTYEEAQDACQKLGAVIATPELLQAAYEAGLHQCSAGWL QDQTVRYPIVHPRKKCSGDSEDVPGVRSYNVRPAHEQYDVYCYMDQIKGEIFHVSSLAGF TYYEAVAHCRKLSSTLASTGELYAAWNQGFHKCSPGWLADRSVRYPVGSPDFDCGGNKTG VQTIYAQPNQTGSPHPYSRYDAYCFKGITAQCVFVQVFHPIVPPLFVDMSGSGSGSGYAS ASTSGSGSDSASGSASGVPDSSSGYISGSGIASGSASGSGQSGDGSGFLVRYQEGTDALM WSSASGSASEAKDGSGSGIIITSGIQSGDQESGEESGHFAVASGLPSGLGSGISGSGTSG FFSGEESSGSGFFSVSFVDTKMIDLTARAFGEQELSGFYTAESGFPSGSGSFSGFETGSA IGFESNSAFGSGSGFETGSAIGFESNSASAFGSGSSSGFESSSAFGFGSGSASGFGSGIA SGIESSPASAFGSGSASGFGSSSAIGLESSSASGFKSVSVTGTSGYPNHPSAPFDPCDPN PCGQGLCSLQDGVALCQCHSGFSGENCSMLVQGCAEGWMEFMGSCYIHFDERETWTSAEQ HCQELNSHLVSISSQQEQEFVKTQAQDYQWIGLNDKDVQNEFRWTDGSPLEYENWRPNQP DNYFSTGEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCTTPPEVQNARMLGNSKDRY PVNSFIRYQCNSGFTQRHLSVVRCLPDGQWEKPRVECIRGIENNRLRKRSLYIRPKAVNS RTWRKVL >tr|E7F537|E7F537_DANRE Aggrecan a OS=Danio rerio OX=7955 GN=acana PE=4 SV=3 MLSLLLLSMCLWVFSATASFDYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTV NDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASI KITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQN SAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDV NETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCN AGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGSG FFPLDLELTTDGDNGVLTVDTITESHTVISKPASTESEVQGEVVTYKPSVTTSVENPYTA LDISHVLPSPPTSSVEKDPDFGSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQ LACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRS YGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQ GFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKED LDLPLNESESQETVTEEKIVSISSHPALHRPEGTPIIAPSPTEPSGTEESVASSSGDLLS SGSGDQPSGSSVSSGDSSGTSSTDDLLTSGSGDQSGSGSSVTSGDYSGASGTDSLFSSGS GDRSSGSFSSSGDFSGASGTDDLLGSGSGEQPSGSFVSSGDFSGASGSGDMSSGSGSSSG SGSGLDILVTFSGIDTVFSGVGSTSGQLEEAGEGSTEILTFQLDQISGSGSGLGSGSGYS SEESGSTSDLSSSSGESGESGDLSGISSGSGFSEESSGFSGFASGIFPSGGSSDISFIDG SGIIMVDRPWMKISSFLTEQELGSGQVDFSGSGLFSGSGVSGDISGLSGEISGSSGDSSG ISSDISGMSGDISGMSGDISGISGDITGMSGDLSGMSSSDHSGSGSGLAFSGVTFLGSGF TDLTEQSREQEASGLVFFGSGEGSGFRSGGYAIESGERSGDSASSDVIFFSNNDMVEMSN KPLQGMELGRGEVEYSGTVRLSSGSGDDQSVFISGHEWIPVTANTPSVKSTDPPPAELFD QGPSDLYSDTAGHLGPYLKPEEIINNLDAVPLAALSSTTETASLQRPAVVERPAVNDYLN PCEPNPCGAGVCSVKDGVGLCHCPPGLHGEECQFDSHSCEKGWTKFQGNCYLHFSKRETW LDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENW RPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGN KKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFGLHDKSVHHSHK ARTALEKQL >XP_038065741.1 fibropellin-3-like [Patiria miniata] MAKLCPKSGYTNWGPGLPDNYGYEDCAYMDPGFYGAGGNWNDVWCFQYYNYICKKRITPSSCDDKPCQNSGVCETDGTGG YQCKCKAGYTGKTCQEDNYCQSGWNHYGDFCYRFSDEYLHFDDRHTWQGALARCQSDGANLVSIHSKDESNFIFDHMGYS RGRFWIGLTDQEREGFFKWSDGTKLDFINWSPRIPDNAGNEDCAHIDSVYFGSQWSDVWCGQIYGYVCKKAAEDIDECKS QPCQNDGTCVDLINDYRCDCVAGYDGKDCENNIDECALTTCLPGFVCVDGINSCCCMATKSMTV
Mafft alignment of selected proteins >sp|P16112|PGCA_HUMAN Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 -MTTLLWVFVTLRVITAAVTV-----ET--SDHDNSLSVSIPQPSPLRVLLGTSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNY PAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITVQTVTWPDMEL------PLPRNITEGEAR GSVILTVKPI-FEVSPSPLEPEEPFTFAPE-----------IGATAFAEVENETGE-ATR PWGFP------------------------------TPGLGPATAFTSEDLVVQVTA---- ------VPGQP--HLPGGVVFHYRPGP-TRYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISA-VPSPGEEEGGTPTSPSGV EEWIVTQVVPGV--AAVPVEEETTAVPSGETTAILEFTTEPENQTE-WEPAYTPVGTSPL P--GILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSP----------- -------------------------------SEEPFPSVRPFPSVEL------------- -----------------------------FPSEEPFPSKEPSPSEEPSASEEPYTPSPPV PSWTELPSSGEESGA--PD--VSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLD--SS GLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEG--SASGVG-DLSG-LP SG-EVLETSASGVGDLSGLPSGEVLETTAPGV-EDISGLPSGEVL--------------- ------ETTAPGV-EDISGLPSGEVL--ETTAPGV-EDISGLPSG-EV-LETTAPGV-ED ISGLPS-GEVLETTAPGVE-DISGLPSGE-------------------VL-ETTAPGVED ISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISG LPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPS GEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEV LETAAPGVEDISGLPSGEVLETAAPGVEDISGLPSGEVLETAAPGV-EDISGLPSG-EVL -ETAAPGVEDISGLPSGEVLETAAPGV-EDISGLP-SG-EV------------------- ---------------------------------------------------------LET AAPGVEDISGLPSGEVL-ETAAPGVEDISGLPSGEVLETTAPGV-EEISGLPSGE-VLET TAPGV-DEISGLPSGEVL-ETTAP------------------------------------ -----------------------GVEEISGLPSGEVL-ETSTSAVG-DLSGLPSGGEVLE ISVSGV-ED--ISGLPSG-EVVETSASGIEDVSELPSGEGL-ETSASGV-EDLSRLPS-G E--------------------EVLEISASGFG-DLSGLPSGGEG-LETSASEVGTDLSGL PSGREGLETSA-----SGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSG LPSG-------FSGEYSGVDLGSGPPSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVVTASTASELEGRGTIGISGA-------GEIS GLPSSE---LDISGRASGLPSGTELSGQASGSPDVSGEIPGLF--GVSGQPSGFPDTSGE T----------------------SGVT-ELSGLSSGQPGISGEASGVLYGTSQPFGITDL SG-ETSGVPDLSGQPSGLPGF--SGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVA-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GK-SGMVDVSGQFSGT-----------VDSSGFTSQTPEFSGLPSG------IAEVSGES SRAEIGSSL-PSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGA HSGAPDMSGEHSGFLDLSGLQ---------SGLIEPS-------GEPPGTPYFSGDFAST TNVSGESSVAMGTSGEASGLP----------------EVTLIT-SEFV-EGVTEPTISQE LGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGA SAAPEASREDSGSPDLSETTSAFHEANLERSS----------GLGVSGSTLTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EASAAPEVSGESTTTSDVGTEAPG-------- ------------LP----------------SATP--------TASGDRTEISGDLSG--H TSQ------LGVVISTSIPESEWTQQTQRPAETHLEIES---SSLLYSGEETHTVETATS PT-DA-----SIPASPEWKRES-------------------------------------- ESTAAAPARSCAEEPCGAG-TC-KETEGHVICLCPPGYTGEHCN---------------- ----------------------IDQEVCEEGWNKYQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRP NQPDNFFAAGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HMPTIRCQPSGHWEEPQITCTDPTTYKRRL QKRSSRHPRRSRPSTA----H >XP_043345769.1 aggrecan core protein isoform X7 [Cervus canadensis] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-APSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPVGEETTATPG--------FTIEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEKPF------------PSEEPFPS---------------------- --------------------EEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEASGV--PE--VSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEVH-----------------LEISASGV-EDISGLPSGGEV--------------- ----HLEISASGV-EDISGLPSGGEVHLEISASGV-EDLSGLPSGEEGHLEISASGV-ED LSVIPS-GEGPEVSVSGVE-DLSGLPSGEGPEVSVSGVEDLSGLPSGEGP-EVS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----VSGVEDLSGLPSGEGPEVSVSGVEDLSGLPSGEGPEVSVSGV-EDLSGLPSG-EGP -EVSVSGVEDLSGLPSGEGPEVSVSGV-EDLSGLP-SG-EGP------------------ --------------------EVSVSGVEDLSGLPSGEGPEVSASGVEDLSRLPSGEGPEV SASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGEGPEVSASGV-EDLGVLPSGEGHLET SASGV-EDLSRLPSGEGHLEISASGEEDLSRLPSGEGPEVSASGVEDLGVLPSGEGHLET STSGVEDLGVLPSGEGHLETSTSGVEDLSRLPSGEGHLETSTSEVE-DLSRLPSGEGHLE TSTSEV-ED--LSRLPSGEGHLETSTSGVEDLSRLPSGEGP-EVSASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSRGEDHLETSASGVG-DLSGL PSGRDGLEISA-----SGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSGI--LEISGQPSGF---SGEISGMT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------IDSSGFTSQPPEFSGLPSG------VTEVSGEA SRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------REPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGA SAAPEASGGASGSPDLSETTSTFHEADLEGTS----------GLGASGSPSAFPQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTTFDVSVEASG-------- ------------SP----------------STTP--------LASGDKTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSAGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDVCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRTLRRSRPSTA----H >KAB0352492.1 hypothetical protein FD754_017349 [Muntiacus muntjak] --------MVNLQ----ALLE-----KK--FEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGEKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-APSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPIGEETTATPG--------FTVEPENKTE-WELTYTPAGTFPL P--G--------------------------AHRRPFCNGSALSLREAVPLRGTIPPRGTI PLRETIPPRGTVPFREAV------------PLREAIPLRGTVPLR--------------- --------------------------------XXXXPSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEASGV--PE--VSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPSESGLPSGEEERITWTSAPKVDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEGH-----------------LEISASGV-EDISGLPSGGEV--------------- ----HLEISASGV-EDLSRLPSGEGP--EISASGV-EDLSGLPSGEEGHLEISASGV-ED LSVIPS-GEGPEVSASGVE-DLSRLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPEVSASGV-EDLSGLPSG-EGP -EVSVSGVEDLSGLPSGVGPEVSASGV-EDLSRLP-SG-E-------------------- ------------------------------------------------------------ ------------------------------------------------------EGHLET STSGV-EDLSRLPSGEG------------------------------------------- ----------------HLETSTSGVEDLSRLPSGEGX----------------------- ----------------------XXXTSGVEDLSRLPSGEGP-EVSASGV-EDLGVLPS-G D--------------------GHLEISASGVE-DLSRLPSGGEDHLEPSASGVG-DLSGL PSGREGLEISA-----SGAADLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSGL--LEVSGQPSGF---SGEISGVT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-ETPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------TDSSGFTSQPPEFSGLPSG------VTEVSGEA SRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------GEPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGIETSSVPESSGEMSAYPEAEVGA SAAPKASGGAFGSPDLSETTSTFHEADLEGTS----------GRGASGSPSAFPQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATLEVSGESTTTFDMSVEASG-------- ------------SP----------------SATP--------LASGDKIDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSAGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDMCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRPLRRSHPSTA----H >KAB0369135.1 hypothetical protein FD755_019140 [Muntiacus reevesi] --------MVNLQ----ALLE-----KK--FEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-APSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPIGEETTATPG--------FTVEPENKTE-WELTYTPAGTFPL P--GIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEKPF------------PSEEPFPSEKPFPPEEL------------F PSEKPFPSEEPFPSEKPFRPEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEASGV--PE--VSGDFTGSGEISGHLDVSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEVH-----------------LEISASGV-EDLSRLPSGEGP--------------- ----------------------------EISASGV-EDLSGLPSGEEGHLEISASGV-ED LSVIPS-GEGPEVSASGVE-DLSRLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------GPEVSVSGV-EDLSGLPSG-EGP -EVSVSGVEDLSRLPSGEGPEVSASGV-EDISRLP-SG-EG------------------- ---------------------------------------------------------PEV SASGVEDLSVLPSGEGHLEISASGVEDLSRLPSGEGPEVSASGV-EDL------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------XXXLPSGEGHLETSTSGVEDLSRLPSGEGP-EVSASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSGGEDHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQGPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS RLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSRL--LEVSGQPSGF---SGEISGVT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-ETPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-MTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------TDSSGFTSQPPEFSGLPSG------VTEVSGEA YRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQATTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------GEPASTPYFSGDFSGT TDVSGESSAAMSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYSPQLFESSGEASASGDV----PRFPGSGIETSSVPESSGEMSAYPEAEVGA SAAPEASGGAFGSPDLSETTSTFHEADLEGTS----------GLGASGSPSAFLQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTTFDVSVEPSG-------- ------------SP----------------SATP--------LASGDKTDTSGDLSG--H TSG------LGIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQIADTATS PT-DA-----SIPTSAAGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDMCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRPLRRSRPSTA----H >OWK08890.1 ACAN [Cervus elaphus hippelaphus] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVK-------AISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-APSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPVGEETTATSG--------FTIEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEKPF------------PSEEPFPSEEPFPSEKPF------PPEELF PSEKPFPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEASGV--PE--VSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPVESGLPSGEEERITWTSAPEVDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEVH-----------------LEISASG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------DLSRLPSGEGP-EVSASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSRGEDHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSGI--LEISGQPSGF---SGEISGMT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------IDSSGFTSQPPEFSGLPSG------VTEVSGEA SRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------REPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGA SAAPEASGGASGSPDLSETTSTFHEADLEGTS----------GLGASGSPSAFPQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTTFDVSVEASG-------- ------------SP----------------STTP--------LASGDKTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSAGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDVCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRTLRRSRPSTA----H >KAF4017792.1 hypothetical protein G4228_009467 [Cervus hanglu yarkandensis] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-APSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPVGEETTATPG--------FTIEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGAATEEHTEGPSATEG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------SX-XX XG-GEVH-----------------L----------------------------------- ----------------------------EISASGV-EDLSGLPSGEEGHLEISASGV-ED LSVIPS-GEGPEVSVSGVE-DLSGLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------EDLSRLPSGEGP-EVSASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSRGEDHLETSASGVG-DLSGL PSGRDGLEISA-----SGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASG LPSG-------FRGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSGI--LEISGQPSGF---SGEISGMT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------IDSSGFTSQPPEFSGLPSG------VTEVSGEA SRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------REPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGA SAAPEASGGASGSPDLSETTSTFHEADLEGTS----------GLGASGSPSAFPQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTTFDVSVEASG-------- ------------SP----------------STTP--------LASGDKTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSAGGTDDS-------------------------------------- EAT-TT------------------------------------------------------ -----------------------DQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRTLRRSRPSTA----H >XP_041442785.1 aggrecan core protein isoform X2 [Xenopus laevis] -MTTLLLVFVCLRVIAAAISV-----EV--TDHHNTLSVIIPLDLPLNVQLGHSLTIPCF FINALDGVTV---APSTAPLTPRIKWSKHVKGKETVLLVATDGHVRVNEAYNGRVSMPTY PLAPTDVSLEISNILSNDSGTYRCEVMHGIEDSQATVEVNVKGVVFHYRAISTRYTLDFE KAKKACIQNSATIATPEQLQAAYDDGYHQCDAGWLSDQTVRYPIHNPREACYGDKDMFPG VRTYGVRETDETYDVYCYVEDMQGEVFYATSPEKFTFDEAEKQCKSLGARLATTGELYVA WKSGMDVCSAGWLGDRSVRYPISIARPNCGGNLVGVRTVYLHP-NQTGYPNPLSRYDAIC YKAGP------------------DE---DITIQTITQPSLEI------IIPRNDTEEEAR GSIA-SLEPT--NFTLTPTDLEEFFTATPE-----------LVLTEGP-FENVTEE---- --VFPLENITALAQT----EAPGT------VNVTFSEGPEFNATTSLEEEIVPVTAAPAE -----VEPEKH--IAKTGVVFHYRAAS-SRYSLNFTEAKKACLVNNAIIATPAQLQAAYE AGFDQCDAGWISDQTVRYPIVTPRENCHGDKNGFPGVRNYGVVNPAARFDVYCFIDKLHG EVFFATQPDQFTFQEANEFCDEQNATLASTGQLYVAWKLGLDKCRAGWLSDGSVRYPIVT PRKACGGDIPGVRTVYLHANQTGFPDPLSKYHAFCFR-------------EEIPEIPSIK EEVIVTQVVSEL--ETLPSGEGPTAEIE--------TTTDFENQTDFWMANVTESPTIEP SVTVSPSVVPIVSPAPEDISGETSGIGS-AISGEPSGV---------------------- ------------------------------------------------------------ ------------------------------------------------PSGEV------- --------SGDVSGA---D--LSGQPSGTEE-SG-FPSGTDISGV--SGLPSGDVSGDVS GDI----------SGDVSG----------------------------------DISGEEP SG-E-------------------------------------------------------- ------------------------------------PDISGLH----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGF PSGAEDISGQV-----SGFPDISGLSSVP--------------------------IETSG LSSGELSGDEIISGSASGIEIISGFSSGIE----------------------DVSGIAS- -----GFPTITHVD---------TTWVESVTKPTETELEGKGEIEFSASSGIELS-GDLS GLES------------SGDLSGFDLSGVTSSVIESSGDISGFISGDISGEPSGMIDLSGE VSGV--TDISGELSGLKDFSGEASGVL-DFSGELSG---LSGESSGIISVSSGYSGDIGI SG-EASGIREISGELSGVPDI--SGLGSGILEI----------PSGVILIDQSLKELS-- Q-PPKKEEEGKGSVGISGFYS---------------------------------GDVDSS GDISGILDVSGEPSGL-----------IDISGFMS-----GGIPSGDIDISGLSDISGAV SGSEYVSGL-QSGFDDVSGV----PTVSHIDFTLKEPPTQGPDTQEAGGSPSVILEFSGI ASGETLPSGTHEGSLESSGI-------------------------------YTSG----- -------------------------------------SVTLIT-DDSV-EAITKPAVSQE LGG---VT-FAYTI----ETSASGDI--------------------GTETSATHE----- ---------------------------------------------TSGKQETTLEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STE------------------------------- ------------------------------------------PSSGHITFLAPESSG--E IS-----------------ETSESETTHAPEEAQQETEL---VTSVASGEVTDEPTIETA SP-SS----------PITIESEGV------------------------------------ -------IGSCADQPCGAG-TC-TEKEGRIYCACPAGFGGDLCN---------------- ----------------------IDLEVCEDGWTKFQGHCYK------HFSERETWVDAEN VCRYHQSHLASILSPEEQEFVNSN---AQDYQWIGLNDKTIENDFRWSDANPLQYENWRP NQPDNFFTTGEDCV-VMIWHERGEWNDVPCNYHLPFTCKKGTVACSDPPAVQNAYTLGKK KVRYEISSLVRYQCN--QGYLQR-------HVPIIRCLPTGHWDEPRILCIDLSTYRR-- HKRSPRSRSRAIATSEQGKAH >XP_030269061.1 aggrecan core protein-like isoform X2 [Sparus aurata] MIRWIVLLSLCLHVISASFDYIYEEHSF--MDPEDVLSVSIPLEGPQRPLLGGSLVLPCY FEDHTVPDPG---APTITPLSHRIKWSLVTKEKVTTILVALEGQVRISESYLDRVHLVGY PVTPTDASIKISELRSTDSGVYRCEVQQGIEDNHDIVHVQVQGIVFHYRAIMGRYTLTFE KANAACTQNSAVMASPEQLQAAFDDGFHQCDAGWLSDQTVRYPIHDPRVNCYGDKEELPG VRTYGVRDLNETYDVYCFTEKMTGRVFYTAAAEKFTFSEAEASCANRGARLATTGQLYLA WQGGMDVCNAGWLGDRSVRYPINIRRPQCGGGLVGVRTVYLHT-NQTGYPLPESRYDAFC YTESPDEEG-------SGFIEEGSG---VLSVTTVTQSP-EV------FFRRTTTESEAV GEVE-TQQPTVVDFTYTLSPTELPLPQPPN----------------------VTE----- ---------------------------------------------LITDLIEPATARPDV ----GREPSKDFVMPPTGVVFHYRSDS-GRYAFTFVEAQRACQSVGASIATPEQLQAAYK AGFHQCDAGWLLDQSVRYPIVFPRDKCTGDLGDQPGVRSYGLRPADERYDVYCYIDGLKG EVFHVRSAEGFTYDEAASSCQEQNAVLASTGELYAAWKMGFDKCRAGWLVDGSVRYPINK PRSECGGGKLGVHTVYANPNQTGFHERDAKFDAYCFRADL-------------------- ---------------LLIANETGLNITE----------------IQEVLLNISSITDL-- ---LRPAVPSIVPPIPVETSGSGSGSAD-FGSGS-------------------------- ------------------------------------------------------------ ------------------------------------------------ASGDN------- --------SGDSSGS--GD--LAA--------SGDGVISGDLSGS-------GDLSG--- -------------SGDLSG-----------------SGDR------VVSG---DSSG--- ------------------------------------------------------------ ----------------------------------S-GDLSGSGD-------RVVSG---- -----------DLSGSG---DLSG--SG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DRVVSG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DLSGS-GDLSG---------- --SGD-RVVSG------------------------------------------------- --------------------------------------DSSGSG---------------- ------------------------------------------------------------ ------------------------DISGSGNQ-----------------------IISGD LSGSKDLAGSAS---AELPSGASGFSS------------------------------TDA SGST-------LSGEGSGITV-------------------------------VFSGID-- -----------------------SIVSAEGSISGEPQEAGEGSTGILIF----------- ----------PSTGEGSGELSGSGDLS-GSGS---------------------------- ----------------------GSGFT-SMGSGSGGSGQFSGMSSGFINGQ-------DF SG--------FSGFPSGSYSGSASGQS--------GELSGSGD-AQILLIDGEMIDVSIR T-TNKEYELGGGLLEFS-------------------------------------GSGDIS G---------------------------------------SGV------------LSGDL SG---------------SGDISG-SGILSVDLSG-SGDISGS-----GILSV-DLSGSGD ISGSGILSGDLSGSGPRSGTEFFSGVTFIGSGFTELTGSSSGE-QEASGYLLYSSGQGSG GHLSGYGGLIY-HSGSGSGMSGSE-----FSTSGEEGSVTFLT-GDFMTELSRDTTPSME LGQ--------------GSVEYSGEGSGSGG----------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------FFSGSGDNRLFTASG--T SSGVSSADLPLVVLPSTSSEWALTETTAGPEEALSGTEL---SQTSGDIDETYGSAPAPA GL-AA----PPTAATPASLQATG------------------TAAEM-------------- DSV-EGVFNPCEPNPCGDASCT-VEDGVPV-C---------------------------- ----------------------HDEQQCEDGWTKFQGNCYL------HFSDREMWLDAEQ RCRDLNAHLVSIITPEEQHFVNSN---AQDYQWIGLNDKTVQNDFRWTDGTPLQYENWRP NQPDNYFNSEEDCV-VMIWHENGQWNDVPCNYHLPFTCKKGPVSCSAPPEVENAHMFGTR REEYPVNSIIRYQCN--PGFTQR-------HPPVVRCRADGQWEKPQVECTDVK-ARRRT QRRSGGR-------------H >XP_023807578.1 aggrecan core protein [Oryzias latipes] MIRLTLLTSLSLSLVSAAFDYISEAHSF--MDPEDVLSVDIPLEEPQRPLLGSSLVLPCF FQDHTVPDPG---APVIPPLSHRIKWSFVTKKNVSTVLVALGGQVRIGKGYLDRVQLLNY PQTPEDASIRISELRSSDTGVYSCEVQLGIEDDHDFVQVYVTGVVFHYRSFMGRYALTFE EAKTTCSQNSAAIASPEQLQAAYDDGFHQCDAGWISDQTVRYPIHDVRVNCFGDKEDLPG VRNYGVRDPREKYDVYCFAEKMTGRVFFTTSVEKFTVSEAALACSRHGAQLATTGQLYIA WQGGMDVCNTGWLADLSVRYPINVRRPQCGGGLLGVRTVYLHP-NQTGFPLPESRHGAFC YADSPDDKS----LNSGSGSGDESG---PWRVSTVTKDP-QL------LFSWVTSESEVV GEME-TQASSALNVTNFENPK---MLVSPT------------------------------ ---------------------------------------------VIITEAMEAINRPGV ----GKEPNTGSTMPPAGVVFHYRSHT-GRYTFNFSEAQLACQSVGGSIASPQQLQAAYE SGYHQCDAGWLLDQTVRYSIVVPRDKCAGDLGDQPGVRSYGMRPADERYDVYCYIEDLRG EVFHLESADGLTYDQAVLSCQEHGGILASTGELYAAWKTGFDKCRAGWLQDGSVRYPINI PRARCGGGKHGVHTVYAHPNQTGFPPREDRYDAYCIRSELL-----VQKNTLYEQYQ--- HHLINNNCCTSTVNILLTANETGPNATD----------------NHNKQLNHTSVADS-- ---FRLSLSSIVPSVYVEMSGSGSGAEN-TAPEFAGGC---------------------- ------------------------------------------------------------ ------------------------------------------------IFMNH------- --------CGELSGSDFGDQIISGDYTSSTDPPGGVVTNSSGSGL--SGSRITDTSG--S SLS---------ESDNMDG-----------------SGAG-----LSGSS---NING-SR SG-F-------------------------NGT-NHVDSLGSG------------------ ---------LSGS-TSMDGLESG------LSGSNS-TDDTGSGLG------GSNST---- -----------DYTGSGL--SGSN--ST-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DDTGSGL-----------SGS -NITNNSGSRLSG---------------SDRTDDPGSG---------------------- ------------------------------------------------------------ --------------------------------------LSGSTR-TDDPG---------- --SGL-RGSNIT------------------------------------------------ --------------------------------------DNSGSGLS--------GSDRTD DPGSGL----------SG------------------------STRT----DDPGSGLS-G S--------------------KITENSGSSHS---------------------G-FSSID GSGSGFIGPSGVDNSGSGLSGLSSVDSSGLGLSGSNSTD-DKG---SGLSGSN---STDY TGSG-------LSGSNSTNDTGSGLSGSNITNNSGS----------------RLSGSDRT DDPGSGLSGSTRTDDPGSGLRGSNITDNSGSGLSGSDRTDDPGSGLSGSTRTDDPGSGLS GSNITENSGSSHSGFSSIDGSGSGFIG-PSGV-DNSG--SGLS--GLS---------SVD SSGL----------GL----GGSSTII-AIGSALSGYSNFDDSGSGLSGSS-------ST DG--------LESGLSGSSSA--DGSG--------STLNGGGYNIPVVLSKLESFALEGG SALSREVKEGRPAILF--FPS---SVE---------------------------GSGEPS G--SRNLSWSGPKTGLASVDSGFS---VESSGGSKAL---SGTTSGFILHQDFSGFKGFT SGSLSGSGSGQTREFEGSGN----PQIFLIHDKL-MDASVNQKQHELGGGPP-VLSGSGD FSGSGILGGSFSDSDPESVSVLSSDVTSIGSGIPEVSVSSAAEHKQASEILLHSSGQGGE IQLSGLRGSTF-VSQSVSGFSRSD-----IPSNEDKVKNLFLR------EDPNRQRKSRE R----------------GSEDHSGDGSQ-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SGNGDAIATTAFFLG--E TSG----------HKQAEATTKPEKVTEVPVD---------------------GSEHVPA GL-EA----RLITAEPAFEET--------------------------------------- SRI-TEDLDVCHPNPCANGATC-VESADSFRCLCLPSYGGERCD---------------- ----------------------VDEQHCAEGWTKFQGNCYL------HVSKRETWPGAEQ HCRSLNAHLVSIITPEEQQFVNAN---AKAYQWIGLNDRTVENDFHWTDCTPVQYQNWKQ NQPDNY-GSGENCV-VMIWLKNGLWNDEPCHYHLPFTCKKGPVSCGEPPHVVNAVMFGRK RLEYPVRSIVRYQCN--PGFRQR-------HSPVIRCQADGLWETPRVECVDAK-ARTRA GAGIIRRLPSATQGTARS--S >KAF7212766.1 aggrecan core protein-like [Nothobranchius furzeri] --------------------------MW---------------KDTQKPSVVSEV----- -QDHTFPDPG---APPIVPLSHRIKWSHVTKEKVTTILVALEGQVHISKSFLDRVHLLSY PQTPTDASLKITELRSSDSGVYRCEVQHGIEDNHDIVHVHVQGIVFHYRAIMGRYTLTFE MAEAACSQNSAVVASSEQLQAAYDDGFHQCDAGWLSDHTVRYPIHDPRVNCYGDKEELPG VRTYGVRDLSETYDVYCFAEKMTGGVFYTTSAEKFTFSEAESACSRQGAQLATTGQLYLA WKSGMDICNAGWLRDGSVRYPINIRRPQCGGGLLGVRTVYLHT-NQTGYPLSESRYDAFC YTEAPDEES--------SGAAEGSG---VLSVTSVTQSP-EL------FFSRVTTESEVI GEVE-TQLPL--DLNETESQTEPSLLQPPS------------------------------ ----------------------------------------------VDDPIEAATAQPGV ----YKEPSETFVVSSEDVVFHYRSSA-GRYAYMFVEAQLACQSVGGSIATPQHLQAAYE AGYHQCDAGWLLDQTVRYPVVFPREKCAGDLGDEPGVRSYGLRPADERYDVYCYTGKLTG EVFHVGSAEGFTYDEAVSSCQNHSAVLASTGELYAAWKMGFDKCRAGWLLDRSVRYPINN PRSECGGGKSGVHTVYAHPNQTRYPELDAKFDAYCFRANV-------------------- ---------------LHQTNKTQLNITV----------------IQEALLNKTSVIDL-- ---LMLNVSSIVLPIPVEMSGSGSGLAD-FGSGSVNGS---------------------- ------------------------------------------------------------ ------------------------------------------------ISGDH------- --------SGNLSGS--GN--LPG--------SGDGLTSGDSSGS-------GDISG--- -------------SRDMSG-----------------SGAL------SGSG---DLSG--- SG-H-------------------------------------------------------- -------------------------------QSSS-GDSSGSGH-------QSSSG---- -----------DSSGSG---HQSS--SG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------DSSGSG--------------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------HQSSS-GDSSG---------- --SGH-QSSSG------------------------------------------------- --------------------------------------DSSGSGHQ-------------- -------------------------------------------SSS----XXXXXXXX-X X--------------------XXGDSSGSGHQ-----------------------SSSGD SSGSGHQSSSGD---SSGSGHLAGSTS------------------------------TGG SGSG-------LSGVGSGITF-------------------------------FFSGAD-- -----------------------NIVSEEGTSSGGPQEAGEGFTENCIV----------- ----------SSSGSWSG--CSSGDLS-PSGS---------------------------- ----------------------GSGAT-KSEDSLGGSGHFSGSTSGFTSGQ-------DL SG-----------FLSGSSSG--SGES--------GELSGSGD-LQIVLVDEKLVHAS-- T-TLKENELGAGPLVFS-------------------------------------GSGDLL G---------------------------------------SSSGSG---------LSGEL SG---------------SGDLQ----ILQIDENL-IDESTAQKGYELGAGPH-VFSGSGD HSGLGVFSGDHSGSASRSESEFVSGVILMGSGLMELTVSSSGEHKEASGIVFYSSGQGSG GQISGFGSSSF-LSGSGSELSGSAVSGSGFSASGEEGSVKLLT-DDLI-KAPRQTEAPQE LGQ--------------GSVQYSGEESGS------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SFSGGRVFDLSTAPGAPT SSVASTEDLSEAVLPSPPAEPVPTEPTRLPEDHPNEAEE---TETFSETYMMPSFERIPE GL-VA----PPTAAKPAFVET--------------------------------------- PAT-AGEVEVCHPNPCANGATC-VESADSFKCLCLPSYGGKHCK---------------- ----------------------IEEQQCEDGWTKFQGNCYL------HISDRKDWLGAEN HCQGLEAHLVSIITPEEQHFVNAF---ANDYKWIGLSDKAVERDFQWTDGTPMQYENWRP NQPDNYFNSGEDCV-VMVWHEKGQWNDVPCNYHLPFTCKKGPVSCGAPPEVENAHTFGAR RLQYPVNSIIRYQCK--PGFRQR-------HLPVVRCQDDGHWEKPRVECTDVK-ARKRI QHRSSWD--PAVSSTE----K >NP_001348429.1 aggrecan core protein isoform 1 precursor [Mus musculus] -MTTLLLVFVTLRVIAAVISE-----EV--PDHDNSLSVSIPQPSPLKVLLGSSLTIPCY FIDPMHPVTT---APSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGED---DITIQTVTWPDLEL------PLPRNVTEGEAL GSVILTAKPI-FDLSPTISEPGEALTLAPE-----------VGSTAFPEAEERTGE-ATR PWGFPAE---------------------------VTRGPDSATAFASEDLVVRVTISPGA ----AEVPGQP--RLPGGVVFHYRPGS-TRYSLTFEEAQQACMHTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEG EVFFATRLEQFTFQEARAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIIT PRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSV-APSPGEEGGSTPTSPSDI EDWIVTQVGPGV--DAVPLEPKTTEVPY--------FTTEPRKQTE-WEPAYTPVGTSPQ P--GIPPTWLPTLPAAEEHTESPSASEEPSASAVPSTS---------------------- ------------------------------------------------------------ --------------------------------------------------EEPYTSSFAV PSMTELPGSGEASGA--PD--LSGDFTGSGDASGRLDSSGQPSGGIESGLPSGDLD--SS GLSPTVSSGLPVESGSASGDGE-VPWSHTPTVGRLPSGGESPEGSASASGTG-DLSG-LP SG-GEI------------------TETSTSGA-EETSGLPSGGDG--------------- -----LETSTSGV-DDVSGIPTGREG-LETSASGV-EDLSGLPSGEEG-SETSTSGI-ED ISVLPTGGESLETSASGVG-DLSGLPSG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GESLETSASGA-EDVTQLPTE---- ----------------RGGLETSASGV-EDITVLP-TG---------------------- ------------------------------------------------------------ ---------------------------------RESLETSASGV-EDVSGLPSGREGLET SASGI-EDISVFPTE--------------------------------------------- ---------------------------------AEGL-DTSASG-G-YVSGIPSGGDGTE TSASGV-ED--VSGLPSG-------------------GEGL-ETSASGV-EDLG--PS-T R--------------------DSLETSASGV--DVTGFPSGRGD-PETSVSGVGDDFSGL PSGKEGLETSA-----SGAEDLSGLPSGKEDLVGSASGALDFGKLPPGTLGSGQTPEVNG FPSG-------FSGEYSGADIGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVITATTSSELEGRGTIGISGS-------GEVS GLPLGE---LDSSADISGLPSGTELSGQASGSPDSSGETSGFF--DVSGQPFGSSGVSEE TSGI--PEISGQPSGTP-DTTATSGVT-ELNELSSGQPDVSGDGSGILFGSGQSSGITSV SG-ETSGISDLSGQPSGFPVF--SGTATRTPDLASGTISGSGESSGITFVDTSFVEVT-- P-TTFREEEGLGSVELSGFPS---------------------------------GETELS GT-SGTVDVSEQSSGA-----------IDSSGLTSPTPEFSGLPSG------VAEVSGEF SGVETGSSL-PSGAFDGSGLVSGFPTVSLVDRTLVESITQAPTAQEAGEGPSGILEFSGA HSGTPDISGELSGSLDLSTLQ---------SGQMETS-------TETPSSPYFSGDFSST TDVSGESIAATTGSGESSGLP----------------EVTLNT-SELV-EGVTEPTVSQE LGHGPSMTYTPRLFEASGDASASGDLGGAVTNFPGSGIEA-SVPEASSDLSAYPEAGVGV SAAPEASSKLSEFPDLHGITSAFHETDLEMTT-P--------STEVNSNPWTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TREGSAAPEVSGESSTTSDIDTGTSG-------- ------------VP----------------SATP--------MASGDRTEISGEWSD--H TSE------VNVAISSTITESEWAQPTRYPTETLQEIES---PNPSYSGEETQTAETTMS LT-DA-----PTLSSSEGSGET-------------------------------------- EST-VADIDECLSSPCLNGATC-VDALDTFTCLCLPSYRGNLCE---------------- ----------------------IDQEQCEEGWTKFQGHCYR------HFHDRETWVDAER RCREQQSHLSSIVTPEEQEFVNKN---AQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRP NQPDNFFATGEDCV-VMIWHERGEWNDVPCNYQLPFTCKKGTVACGDPPVVEHARTLGQK KDRYEISSLVRYQCT--EGFVQR-------HVPTIRCQPSGHWEEPRITCTDPNTYKHRL QKRSMRPTRRSRPSMA----H >XP_038956962.1 aggrecan core protein isoform X1 [Rattus norvegicus] -MTTLLLVFVTLRVIAAVISE-----EV--PDHDNSLSVSIPQPSPLKALLGTSLTIPCY FIDPMHPVTT---APSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDLEL------PLPRNITEGEAR GNVILTAKPI-FDMSPTVSEPGEALTLAPE-----------VGTTVFPEAGERTEK-TTR PWGFPEE---------------------------ATRGPDSATAFASEDLVVRVTISPGA ----VEVPGQP--RLPGGVVFHYRPGS-TRYSLTFEEAQQACIRTGAAIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEG EVFFATQMEQFTFQEAQAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIVN PRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSV-APSP----GGTPTSPSDI EDWIVTRVEPGV--DAVPLEPETTEVPY--------FTTEPEKQTE-WEPAYTPVGTSPL P--GIPPTWLPTVPAAEEHTESPSASQEPSASQVPSTS---------------------- ------------------------------------------------------------ --------------------------------------------------EEPYTPSLAV PSGTELPSSGDTSGA--PD--LSGDFTGSTDTSGRLDSSGEPSGGSESGLPSGDLD--SS GLGPTVSSGLPVESGSASGDGE-IPWSSTPTVGRLPSGGESLEGSASASGTG-DLSG-LP SG-GEI------------------TETSASGT-EEISGLPSGGDD--------------- -----LETSTSGI-DGASVLPTGRGG-LETSASGV-EDLSGLPSGEEG-SETSTSGI-ED ISVLPT-GESPETSASGVG-DLSGLPSG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------GESLETSASGV-EDVTQLPTE---- ----------------RGGLETSASGI-EDITVLP-TG---------------------- ------------------------------------------------------------ ---------------------------------RENLETSASGV-EDVSGLPSGKEGLET SASGI-EDISVFPTE--------------------------------------------- ---------------------------------AEGL-ETSASG-G-YVSGIPSGEDGTE TSTSGV-EG--VSGLPSG-------------------GEGL-ETSASGV-EDLG--LP-T R--------------------DSLETSASGV--DVTGYPSGRED-TETSVPGVGDDLSGL PSGQEGLETSA-----SGAEDLGGLPSGKEDLVGSASGALDFGKLPSGTLGSGQTPEASG LPSG-------FSGEYSGVDIGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVITATTASELEGRGTISVSGS-------GEES GPPLSE---LDSSADISGLPSGTELSGQTSGSLDVSGETSGFF--DVSGQPFGSSGTGEG TSGI--PEVSGQPSGSP-DTTE---IS-ELSGLSSGQPDVSGEGSGILFGSGQSSGITSV SG-ETSGISDLSGQPSGFPVL--SGTTPGTPDLASGAMSGSGDSSGITFVDTSLIEVT-- P-TTFREEEGLGSVELSGLPS---------------------------------GETDLS GT-SGMVDVSGQSSGA-----------IDSSGLISPTPEFSGLPSG------VAEVSGEV SGVETGSSL-SSGAFDGSGLVSGFPTVSLVDRTLVESITLAPTAQEAGEGPSSILEFSGA HSGTPDISGDLSGSLDQSTWQ---------PGWTEAS-------TEPPSSPYFSGDFSST TDASGESITAPTGSGETSGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGHGPSMTYTPRLFEASGEASASGDLGGPVTIFPGSGVEA-SVPEGSSDPSAYPEAGVGV SAAPEASSQLSEFPDLHGITSASRETDLEMTT-P--------GTEVSSNPWTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TREGSAAPEVSGESSTTSDIDAGTSG-------- ------------VP----------------FATP--------MTSGDRTEISGEWSD--H TSE------VNVTVSTTVPESRWAQSTQHPTETLQEIGS---PNPSYSGEETQTAETAKS LT-DT-----PTLASPEGSGET-------------------------------------- EST-AADIDECLSSPCLNGATC-VDALDTFTCLCLPSYRGDLCE---------------- ----------------------IDQEQCEEGWTKFQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNKN---AQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRP NQPDNFFATGEDCV-VMIWHERGEWNDVPCNYQLPFTCKKGTVACGEPPAVEHARTLGQK KDRYEISSLVRYQCT--EGFVQR-------HVPTIRCQPSGHWEEPRITCTDPNTYKHRL QKRSMRPTRRSRPSMA----H >XP_024837356.1 aggrecan core protein isoform X1 [Bos taurus] -MTTLLLVFVTLRVITAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNMRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPESFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GSVILTAKPD-FEVSPTAPEPEEPFTFVPE-----------VRATAFPEVENRTEE-ATR PWAFPRE---------------------------STPGLGAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAIIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSA-APSPEEEEGSAPTAGPDV EEWMVTQVGPGV--AAVPIGEETTAIPG--------FTVEPENKTE-WELAYTPAGTLPL P--GIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEEPF------------PSEKPFPPEELFPSEKP------------I PSEEPFPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEVSGV--PE--ISGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEV----SGVE-DISG-LP SG-GEVH-----------------LEISASGV-EDISGLPSGGEV--------------- ----HLEISASGV-EDLSRIPSGEGP--EISASGV-EDISGLPSGEEGHLEISASGV-ED LSGIPS-GEGPEVSASGVE-DLIGLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GPEVSASGVEDLSRLPSGEGPEVSASGV-EDLSGLPSG-EGP -EVSVSGVEDLSRLPSGEGPEVSASGV-EDLSRLP-SG-EG------------------- ---------------------------------------------------------PEI SVSGVEDISI--------------------LPSGEGPEVSASGV-EDLSVLPSGEGHLEI STSGV-EDLSVLPSGEG------------------------------------------- ----------------HLEISASGVEDISRLPSGEGP-EVSASGVE-DLSVLPSGEDHLE ISASGV-ED--LGVLPSGEDHLEISASGVEDISRLPSGEGP-EVSASGV-EDLSVLPS-G E--------------------GHLEISASGVE-DLSRLPSGGEDHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLESGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGLF--GVSGQPSGFPDISGE TSGL--LEVSGQPSGF---YGEISGVT-ELSGLASGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAVSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEVGVS GT-SGLADVSGLSSGA-----------IDSSGFTSQPPEFSGLPSG------VTEVSGEA SGAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPS-------GEPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGVEVSSVPESSGETSAYPEAEVGA SAAPEASGGASGSPNLSETTSTFHEADLEGTS----------GLGVSGSPSAFPEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTAFDVSVEASG-------- ------------SP----------------SATP--------LASGDRTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPASAGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDVCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRPLRRSHPSTA----H >XP_015147464.2 aggrecan core protein isoform X1 [Gallus gallus] -MTTLLLVFVCLQAITTAASA-----EL--SDSSDGLEVKIPEQSPLRVVLGSSLNIPCY FNIPEEEDT-------NALLTPRIKWSKLSNGTEIVLLVATGGKIRLNAEYREVISLPNY PAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGVVFHYRAISTRYTLNFE RAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHLPRERCYGDKDEFPG VRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTGELYLA WKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPANQTGYPHPSSRYDAIC YSGDDFEAL----VPGLFTDEVGTELGSAFTIQTVTQTEVEL------PLPRNVTEEEAR GSIA-TLEPM--EITATATELYEAFTVLPDLFATSV-----TVETASPREENVTREEITG IWAVPEEVTTSVSGTAFTTGMAEVSSVEEAIAVTATPGLESASPFTIEDHLVQVTAAPDV ----ALLPRQP--ISPTGVVFHYRAAT-SRYAFSFIQAQQACLENNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKG EVFFATQPEQFTFQEAQLYCESQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVS PRPACGGDAPGVRTIYQHHNQTGFPDPLSRHHAFCFRAL----PSVVE-EGVTSLFE--- EEVMVTQLIPGV--EGIPSGEETTVETE--------LSSEPENQTA-QGTEVFPTDVSLL S--ARPSAFPPATVIPEETSTNASIPEV---SGEFPES---------------------- ------------------------------------------------------------ --------------------------------------------GEHPTSGEPS------ -----------ASGA--PD--TSGEPT-----SVGFELSGEQSGIGESGLPSVDLQ--SS GF-------VPGESGLPSG----------------------------------DVSG-LP SG-I-------------------------------------------------------- ------------------------------------VDISGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSAEEEVTVSV-----SRIPEVSGMPSG---------------------------AESSG LHSG-------FSGEISGTELISGLPSG------------------------EESGLAS- -----GFPTISLVD---------STLVEVVTAAPGRQEEGKGSIGVSGE-------EELS GFPSAE---WDSS-GARGLPSGAETSGEQSGVPELSGEHSGVP--GLSGEPFEVPELSGE HSGV--TELSGE----------HSGLP-ELSGEPFGVPELSGFPSGL-----------DI SG-EPSGAPEV----SGPVDV--SGLTSGV--------DGSGEVSGVTFISTSLQEVT-- T-PSVAEAEAKEILEISGLPS---------------------------------G--ETS GMVSGSLDVSGQPSGH-----------IDFGGSASGVLEMSGFPSG------AVESSGEA SGVEVTSGL-ASG--EESGLTSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGF LSGDRGVSGDGSGAVQSSGLP---------SGTGDFS-------GEPSGIPYFSGDISGA TDLSGQPSAVTDISGEDSGLP----------------EVTLVT-SDLV-EVVTRPTVSQE LGGETAVT-FPYVFGPSGEGSASGDLSGGASA--EGGIETSTAYEISGESSAFPETSIET STDQEISGEASAYPEISVETSTHLETSGETSAYPEISTETSTIQEVSGETSAFPEI---- ------------------------------------STETSTIQEISGETSAFPEIRIET STFQEISGETSAFPEIRIETSTSQEARGET--------------------SAFPEITIEA STVHETSGETSAFPEISIETSTVHETSGETSAFPEISIETSTVHEISGESSAFPEIRIET STSQEARGETSAFPEITIEASTIQEISGETSAFPEISIATSTVREISGETSAFPEIRIET STSQEARGETSALPEITIETSTVHETSGEASAFPEISIETSTRQEARGEASAYPEVSIEA STTQEVSGESSAFPEISVETSTSQEARGETSAFPEIGIETSTAHEGSGETPG-------- ------------LPAVSTDTAATSLASGEPSGAP--EKETPDTTS----HLITGVSG--E TSV------PDAVISTSAPDVELAQEPRNTEETQLEIEP---STPAASGQETETAAVLDN PHLPATATAALHPASQEAVDAL-------------------------------------- GPT-TEDTDECHSSPCLNGATC-VDGIDSFKCLCLPSYGGDLCE---------------- ----------------------IDLANCEEGWIKFQGHCYR------HFEERETWMDAES RCREHQAHLSSIITPEEQEFVNSH---AQDYQWIGLSDRAVENDFRWSDGHSLQFENWRP NQPDNFFSAGEDCV-VMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRK KDRYEINSLVRYQCD--HGYIQR-------HVPTIRCQPNGHWEEPRISCTNPSSYQRRL YKRSPRSRLRPG--VVHRPTH >XP_020953956.1 aggrecan core protein isoform X1 [Sus scrofa] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPQPSPLRVLLGGSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGQVRVNSAYQDRVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GTVILTVKPV-FEFSPTAPEPEEPFTFAPG-----------TGATAFPEAENRTGE-ATR PWAFPEE---------------------------STPGLGAPTAFTSEDLVVQVTMAPGA ----TEFPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSTPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLASTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAVAPSPGEEEGGTPTSLPDL EERIATQVGPGV--AAVPVGEETTEVAA--------FTTEPENRTE-WEFVYTPVGTSPL P--GIPPTWPPTSAATEEGTEGPSATEAPSTSEEPFPSEKPFPSEEPF------------ ------------------------------------------------------------ ------------------------------PSEEPFPSEKPSASEEPFPSEQPSTLSAPV PSRTELPGSGEVSGA--PE--VSGDFTGSGEVSGHLDYSGQPSGEIASGLPSEDLD--SS GLTSAVGSGLPVESGLASGDEDKITWSSTSKVDRLPSGGEGPEG--SVSGVE-DLSG-LP SG-EGPEISASGVEDLSRLPSGEGPEISASGV-EDLSRLPSGEGP--------------- ------EISASGI-EDISQLPSGEGP--EISASGI-EDLSRLPSG-EG-PEISASGV-ED LSRLPS-GEGPEISASGVE-DISQLPSGE-------------------GP-EIS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ASGVEDLSRLPSGEGPEISASGVEDISQLPSGEGPEISASGV-EDLSRLPSG-EGP -EISASGVEDLSRLPSGEGPEISASGV-EDISQLP-SG-EGPEISASGVEDLSRLPSGEG PEISASGVEDISQLPSGEGPEISVSGVEDLSRLPSGEGPEISASGVEDLSRLPSGEGPEI SASGVEDISQLPSGEGP-EISASGVEDLSRLPSGEGPEISASGV-EDLSRLPSGEGP-DI SASGV-EDLSRLPSGEGP-EISASGIEDLSRLPSGEGPEISASGVEDLSRLPSGEGP-EI SASGVEDISQLPSGE-GPEISASGVEDLSRLPSGEGP-EISASGVE-DISQLPSG-EGPE ISASGV-ED--LSRLPSG-EGPEISASGVEDISQLPSGEGP-EISASGV-EDLSRLPSGG E--------------------GHLETSASGVE-DLSGIPSGGEDHLESSASGVG-DLSGL PSGREGLEIYA-----SGAEDLSGLTSGKEDLAGSASGDLDVGRMPSGTLESGQAPEVSG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSELPS- -----GFPTVSLVD---------TTLVEMVTATTASELEGRGTIGVSGA-------GETF GLPFSE---LDISGGASGHPSGAELSGQASGSPDISGETSGLF--DVSGQPSGFPDISGG TSGL--FEVSGQPSGF---SGATSGVT-ELSGLSSGQPDISGDASGVLSGVGQPFGLTDV SG-ETSGVPDLSGQPSGWPGF--SGMPSGTPDLVSSATSGSGESSGITFVDTSLVEVT-- P-TTRKEEEGLGSVELSGLPS---------------------------------GEADLS GA-SGVVDVSGLASGA-----------TDSSGFTSQPPEFSGLPSG------VTEVSGES SGVEIGSSL-PSGAYDGSGLPLSAPTVYLVDRTLVESVTQAPTAQEAGEGPPGTLELSGA HSGVPDMSGDHSGSVDLSGLQ---------SGLAEPS-------GEPASTPYFSGDFSVT TDISGDSSAATSTSGEASGLP----------------EVTLIA-SEFV-EGVTEPTVSQE LGQRPPVTHTPQLFESSGEASASGDV----PRFPGSGVEAPPIPESSRESSAYPEAETGA SAAPEASGGASGSPDLTEATSAFHEADLEGTS----------GLGVSVSTSAFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------TREVSAAPEVSRESTTTYDVGPEASG-------- ------------LP----------------LATP--------VSSGDRTEVSGDLSG--H TSG------LEVAISTAIPEYAWTQQTQRPAEAPLEIES---SSPVHSGEEMPTAKPATS QT-EA-----SIPTPPGQTDES-------------------------------------- EAT-TADFDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDLCE---------------- ----------------------IDQKLCENGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINSLVRYQCT--EGFVQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRSLRRSRPSTG----P >NP_001106926.3 aggrecan core protein precursor [Canis lupus familiaris] -MTTLLLVFVTLRVITAASSL-----EA--SDPDNSLSVSIPEPSPMRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRITKEKEVVLLVATEGQVRINSAYQDKVSLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTVKPI-FDLSPTAPEPEEPFTFVPE-PEKPFTFATDVGVTAFPEAENRTGE-ATR PWGVPEE---------------------------STPGP-AFTAFTSEDHVVQVTAVPGA ----AEVPGQP--RLPGGVVFHYRPGS-ARYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDKLEG EVFFITRLEQFTFQEALAFCESHNATLASTGQLYAAWSQGLDKCYAGWLSDGSLRYPIVT PRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSA-VPSPGEEEGGTPTPS-VV EDWIATQVGPGV--AAVPMGEETTAILD--------FTIEPENQTE-WEPAYSPAGTSPL P--GIPPTWPPTSTATEESTEGPSGTEVPSVSEEPSPS---------------------- ------------------------------------------------------------ --------------------------------------------EEPFPWEELSTLSPPG PSGTELPGSGEASGV--PE--VSGDFTGSGEVSGHPDSSGQLSGESASGLPSEDLD--SS GLTSAVG------SGLASGDEDRITLSSIPKV-----EGEGLET--SASGVE-DLSG-LP SGREGLETSTSGVGDLSGLPSGEGLEVSASGV-EDLSGLPSGEGP--------------- ------ETSASGV-GDLSRLPSGEGP--EVSASGV-GDLSGLPSGREG-LETSTSGV-ED LSGLPS-GEGPEASTSGVG-DLSRLPSGE-------------------GP-EVS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ASGVEDLSGLPSGEGLEASASGVGDLSGLPSGEGPEASASGV-GDLSRLPSG-EGP -EVSASGVEDLSGLSSGESPEASASGV-GDLSGLP-SGREG------------------- ---------------------------------------------------------LET SASGVGDLSGLPSGEGQ-EASASGVEDLSRLPSGEGPEASASGV-GELSGLPSGREGLET SASGV-GDLSGLPSGEGP------------------------------------------ ------------------EAFASGVEDLSILPSGEGP-EASASGVG-DLSGLPSGREGLE TSTSGV-GD--LSGLPSGREGLETSTSGVGDLSGLPSGEGP-EASASGI-GDISGLPS-G REGLETSSSGVE---------DHPETSASGVE-DLSGLPSGVEGHPETSASGVE-DLSEL SSGGEGLETSA-----SGAEDLSGLPSGKEDLIGSASGALDFGRIPSGTLGSGQAPEASS LPSG-------FSGEYSGVDFGSGPSSGLP----------------------DFSGLPS- -----GFPTISLVD---------TTLVEVITTTSASELEGRGTIGISGA-------GETS GLPVSE---LDISGAVSGLPSGAELSGQASGSPDMSGETSGFF--GVSGQPSGFPDISGG TSGL--FEVSGQPSGF---SGETSGVT-ELSGLYSGQPDVSGEASGVPSGSGEPFGMTDL SG-ETSGVPDISGQPSGLPEF--SGTTSGIPDLVSSTMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEVDLS GA-SGTMDISGQSSGA-----------TDSSGLTSQLPEFSGLPSG------AAEVSGES SGAEIGSSL-PSGTYEGSGLPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGA HSGAPDVSGDHSGSLDLSGMQ---------SGLVEPS-------GEPSSTPYFSGDFSGT MDVTGEPSTAMSASGEASGLL----------------EVTLIT-SEFV-EGVTEPTVSQE LAQRPPVTHTPQLFESSGEASASGEISGATPAFPGSGLEASSVPESSSETSDFPERAVGV SAAPEASGGASGAPDVSEATSTFPEADVEGAS----------GLGVSGGTSAFPEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PREGSATPEVQEEPTTSYDVGREALG-------- ------------WP----------------SATP--------TASGDRIEVSGDLSG--H TSG------LDVVISTSVPESEWIQQTQRPAEAHLEIEA---SSPLHSGEETQTAETATS PTDDA-----SIPTSPSGTDES-------------------------------------- APA-IPDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYRGDLCE---------------- ----------------------IDQELCEEGWTKFQGHCYR------YFPDRESWVDAES RCRAQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHSLQFENWRP NQPDNFFVSGEDCV-VMIWHEKGEWNDVPCNYYLPFTCKKGTVACGDPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HVPTIRCQPSGHWEKPRITCTDPSTYKRRL QKRSSRAPRRSRPSTA----H >XP_027812861.1 aggrecan core protein isoform X1 [Ovis aries] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEPEEPFTFAPE-----------VRATAFPEVENRTGE-ATW PWAFPRE---------------------------STPGVGAPTAFTSEDLVVQVTLAPGA ----TEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKEACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGLRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-VPSPGEEEGSTPTAGPEV EDWIVTEVGPGV--AAVPVGEETTAVPG--------FTVEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEKPFPPEELFPSEKPFPSEKPF PSEKPFPSEKPFPSEKPFPPEELFPSEKPIPSEEPFPSEKPFPSEEPFPSEKPIPSEEPF PSEKPFRPEEPFPSEKPIPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEEPSTLSAPV PSRTELPTSGEASGV--PE--VSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLD--SS GLTPTVGSGLPVESGLPSGEEERITWTSPPIVDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEVH-----------------LEISASGV-EDLSRLPSGEGPEVSASGVEDLSGLPS GEEGHLEISASGV--DLSGIPSGEGP--EVSASGV-EDLGVLPSG-EGHLEISASGV-ED LSRLPS-GEGPEVSASGVE-DLGVLPSGE-------------------GHLEIS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----ASGVEDLSRLPSGEGPEVSASGVEDLSRLPSGEGPEVSASGV-EDLSRLPSGGEVH LEISASGVEDLSRLPSGEGPEVSASGV-EDLSGLP-SGEEGHL----------------- --------------------EISASGV-DLSGIPSGEGPEVSASGVEDLSRLPSGEGPEV SASGVEDLSRLPSGEGP-EVSASGVEDLSRLPSGEGPEVSASGV-EDLSRLPSGEGP-EV SAPGV-EDLSRLPSGEGP-EVSASGVEDLSRLPSGEGPEVSASGVEDLSRLPSGE----- ----------------GPEVSASGVEDLSRLPSGEGP-EVSASGVE-DLSRLPSGEGP-E VSASGV-ED--LGVLPSGEGHLEISASGVEDLSRLPSGEGP-EVSASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSGGEDHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GLPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPEISGETSGLF--GVSGQPSGFPDISGE TSGL--LEVSGQPSGF---SGEISGVT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGVPDLVSSAVSGSGESSGIMFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEAGLS GT-SGLVDVSGLSSGA-----------IDSSGFTPQPPEFSGLPSG------VTEVSGEA SGAASGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGT PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPR-------GEPASTPYFSGDFSGA TDVSGESSAATSTSGEPSGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPKLFESSGEASVSGDV----PSFPGSGVEASPVPESSGETSAYPEAEVGA SAAPEASGGASGSPNLSETTSTFHEADLEGTS----------GLGASGRPSAFPEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTAFDVSVEASG-------- ------------SP----------------SATP--------LASGDRTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSTGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDMCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRPLRRSRPSTA----H >XP_003952775.3 LOW QUALITY PROTEIN: aggrecan core protein [Pan troglodytes] -MTTLLWVFVTLRVITAAVTV-----ET--SDHDNSLSVSIPQPSPLRVLLGTSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNY PAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDMEL------PLPRNITEGEAR GSVILTVKPI-FEVSPSPLEPEEPFTFAPE-----------IGATAFPEVENETGE-ATR PWGFP------------------------------TPGLGPATAFTSEDLVVQVTA---- ------VPGQP--HLPGGVVFHYRPGP-TRYSLTFEEAQQACLHTGAVIASPEQLQAAYE AGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISA-VPSPGEEEGGTPTSPSGV EEWIATQVVPGV--AAVPVEEETTAVPSGETTAILEFTTEPENQTE-WEPAYTPVGTSPL P--GILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSP----------- -------------------------------SEEPFPSVRPFPSVEL------------- -----------------------------FPSEEPFPSKEPSPSEEPSASEEPYTPSPPV PSWTELPSSGEESGA--PD--VSGDFIGSGDVSGHLDFSGQLSGDRASGLPSGDLD--SS GLTSTVGSVLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEG--SASGVG-DLSG-LP SG-EVLETSASGVGDLSGLPSGEVLETTAPGV-EDISGLPSGEVL--------------- ------ETTAPGV-EDISGLPSGEVL--ETTAPGV-EDISGLPSG-EV-LETTAPGV-ED ISGLPS-GEVLETTAPGVE-DISGLPSGE-------------------VL-ETTAPGVE- ------------------------------------------------------------ ------------------------------------------------------------ -------------ISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGVEXISGLPSGEV LETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGV-EDISGLPSG-EVL -ETTAPGVEDISGLPSGEVLETTAPGV-EDISGLP-SG-EV------------------- ---------------------------------------------------------LET TAPGVEDISGLPSGEVL-ETTAPGVEDISGLPSGEVLETTASGV-EDISGLPSGE-VLET TAPGV-EEISGLPSGEVL-ETTAS------------------------------------ -----------------------GVEEISGLPSGEVL-ETSTSAVG-DVSGPPSGGEVLE ISASGV-ED--ISGLPSG-EVVETSASGIEDVSELPSGEGL-ETSASGV-EDLSRLPS-G E--------------------EVLEISASGFG-DLSGLPSGGEG-LETSASEVGTDLSGL PSGREGLETSA-----SGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSG LPSG-------FSGEYSGVDLGSGPPSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVVTASTASELEGRGTIGISGA-------GEIS GLPSSE---LDISGRASGLPSGTELSGQASGSPDVSGEIPGLF--GVSGQPSGFPDTSGE T----------------------SGVT-ELSGLSSGQPGVSGEASGVLYGTSQPFGITDL SG-ETSGVPDLSGQPSGLPGF--SGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVA-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GK-SGMVDVSGQFSGT-----------VNSSGFTSQTPEFSGLPSG------IAEVSGES SRAEIGSSL-PSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGA HSGAPDMSGEHSGFLDLSGLQ---------SGLVEPS-------GEPPGTPYFSGDFAST TNVSRESSVAMGTSGEASGLP----------------EVTLIT-SEFV-EGVTEPTVSQE LGQRPPVTHTPQLFESSGDVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGA SAAPEASREDSGSPDLSETTSAFHEADLERSS----------GLGVSGSTLTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EASAAPEVSGESTTTNDVGTEAPG-------- ------------LP----------------SATP--------TASGDRTEISGDPSG--H TLR------LGVVISTSIPESEWTQQTQRPAETHLEIES---SSLLYSGEETHTVKTATS PT-DA-----SIPASPEWKRES-------------------------------------- ESTAAAPARSCAEEPCGAG-TC-KETEGHVICLCPPGYTGEHCN---------------- ----------------------IDQEVCEEGWNKYQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRP NQPDNFFAAGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HMPTIRCQPSGHWEEPRITCTDPTTYKRRL QKRSSRHPRRSRPSTA----H >XP_008249943.1 PREDICTED: aggrecan core protein isoform X1 [Oryctolagus cuniculus] -MTTLLLVLVALRVIAAAISG-----DV--SDLDNALSVSIPQPSPVRALLGTSLTIPCY FIDPVHPVTT---APSTAPLTPRIKWSRISKDKEVVLLVANEGRVRINSAYQDKVSLPNY PAIPSDATLEIQSLRSNDSGIYRCEVMHGLEDSEATLEVVVKGVVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAASECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFMD-----IPENFFGVGGEE---DITVQTVTWPDVEL------PVPRNITEGEAR GSVVLTAKPV-LDVSPTAPQPEE--TFAPG-----------VGATAFPGVENGTEE-ATR PRGFADE---------------------------ATLGPSSATAFTSADLVVQVTAAPGV ----AEVPGQP--RLPGGVVFHYRPGP-TRYSLTFEEAQQACLRTGAAMASAEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFQEALEFCESHNATLASTGQLYAAWSRGLDRCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGTSE-APSPGPEEGGTATPASGL EDWIVTQVGPGV--AATPRAEERTAVPS--------FATEPGNQTG-WEAASSPVGTSLL P--GIPPTWPPTGTAAEGTTEGLSTAAMPSASEGP------------------------- ------------------------------------------------------------ -----------------------------------------------------YTPSSLV ARETELPGLGVTSVP--PD--ISGDLTSSGEASGLFGPTGQPLGGSASGLPSGELD--SG SLTPTVGSGLPIGSGLASGDEDRIQWSSSTEVGGVTSGAEIPET--SASGVGTDLSG-LP SG-AEI------------------PETFASGVGTDLSGLPSGAEI--------------- -----PETFASGVGTDLSGLPSGAEI-LETSASGVGTDLSGLPSGAEI-LETSASGVGTD LSGLPSGAEILETSASGVGTDLSGLPSG-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------AEIPETFASGVGTDLSGLPSG---- ----------------AEILETSASGVGTDLSGLP-SG---------------------- ------------------------------------------------------------ ---------------------------------AEIPETSASGVGTDLSGLPSGAEILET SASGVGTDLSGLPSG--------------------------------------------- ---------------------------------AEIL-ETSASGVGTDLSGLPSGAEILE TSASGVGTD--LSGLPSG-------------------AEIL-ETSASGVGTDLSGLPS-G A--------------------EILETSASGVGTDLSGLPSGGEI-PETFASGVG-DLSGL PPGREDLETLT-----SGVGDLSGLSSGKDGLVGSASGALDFG----GTLGSGQIPETSG LPSG-------YSGEYSEVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TPLVEVVTATTARELEGRGTIGISGA-------GEIS GLPSSE---LDVSGGT----SGADISGEA----DVGGEASGLI---VRGQPSGFPDTSGE A----------------------FGVT-EVSGLSSGQPDLSGEASGVLFGSGPPFGITDL SG-EP------SGQPSGLPEF--SGTTHRIPDLVSGATSGSGESSGIAFVDTSVVEVT-- P-TTLREEEGLGSVEFSGFPS---------------------------------GETGLS GT-PETIDVSGQSSGT-----------IDSSGFTSLAPEVSGSPSG------VAEVSGEA SGTEITSGL-PSGVFDSSGLPSGFPTVSLVDRTLVESVTQAPTAQEA-EGPSDILELSGV HSGLPDVSGAHSGFLDPSGLQ---------SGLVEPS-------GEPPRTPYFSGDFPST PDVSGEASAATSSSGDISGLP----------------EVTLVT-SEFM-EGVTRPTVSQE LGQGPPMTHVPKLFESSGEALASGDTSGAAPAFPGSGLEASSVPESHGETSAYAEPGTKA AAAPDASGEASGSPDSGEITSVFREAAGEGAS----------GLEVSSSSLASQQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PREGSASPEVSGESTTSYEIGTETSG-------- ------------LP----------------LATP--------AASEDRAEVSGDLSG--R TP-------VPVDVVTNVPEAEWIQHSQRPAEMWPETKS---SSPSYSGED--TAGTAAS PA-SA-----DTPGEPGPTTAA-------PRSCAEEPCGPGTCQETEGRVTCLCPPGHTG EYC-DIDIDECLSSPCVNGATC-VDASDSFTCLCLPSYGGDLCE---------------- ----------------------TDQEVCEEGWTKFQGHCYR------HFPDRETWVDAEG RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVEHARTFGQK KDRYEINSLVRYQCA--EGFTQR-------HVPTIRCQPSGHWEEPRITCTHPTTYKRRV QKRSSRTLQRSQASSA----P >XP_024088629.1 LOW QUALITY PROTEIN: aggrecan core protein [Pongo abelii] -MTTLLWVFVTLRVITAAVTV-----ET--SDHDNSLSVSIPQPSPLRVLLGTSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQEKVSLPNY PAIPSDATLEIQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD KAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITVQTVTWPDMEL------PLPRNITEGEAR GSVILTVKPI-FEVSPSPLEPEEPFTFAPE-----------IGATAFPEVENETGE-ATR PWGFP------------------------------TPGLGPATAFTSEDLVVQVTA---- ------VPGQP--HLPGGVVFHYRPGP-TRYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISA-VPSPGEEEGGTPTSPSGV EEWIATQVVPGV--AAVPVEEETTAVPLGETTAILEFTTEPENQTE-REPVYIPVGTSPL P--GILPTWPPTGAATEESTEGPSATEVPSASEKPSPSEVPFPSEEPSP----------- -------------------------------SEEPFPSVRPFPSVEL------------- -----------------------------FPSEEPFPSKEPSPSEEPSASEEPYTPSPPV PSWTELLSSGEESGA--PD--VSGDFTGSGDVSGHLDFSGQLSGERASGLPSGDLD--SS GLTSTVASGLPVESGLASGDEERIEWSSTPTVGELPSGAEILEG--SISGVG-DLSG-LP SG-EVLETTAPGVEDISGLPSGEVLETTAPGV-EDISGLPSGEVL--------------- ------ETTAPGV-EDISGLPSGEVL--ETTXPGV-EDISGLPSG-EV-LETTXPGV-ED ISGLPS-GEVLETTXPGVE-DISGLPSGE-------------------VL-ETT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGV-EDISGLPSG-EVL -ETTAPGVEDISGLPSGEVLETTAPGV-EDISGLP-SG-EV------------------- ---------------------------------------------------------LET TAPGVEDISGLPSGEVL-ETXCPGVEDISGLPSGEVLETTAPGV-EDISGLPSGE-VLET TAPGV-EDISGLPSGEVL-ETTAPGVGDLSGLPSGE------------------------ ----------------VLETSTSGVGDLSGLPSGEVL-ETSTSAVG-DLSGLPSGGEVLE TSASGV-ED--ISGLPSG-EVVETSASGIEDVSELPSGEGL-ETSASGV-GDLSRLPS-G EEVLETSASGVRDISGLPSGGEVLEISASGVG-DLSGLPSGVEG-LETSASEVGTDLSGL PSGREGLETSA-----SGTEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVVTASTASELEGRGTIGISGA-------GEIS GLPSSE---LDISGGASGLPSGTELSGQASGSPDVSGEIPGLF--GVSGQPSGFPDTSGE T----------------------SGVT-ELSGLSSGQPGVSGEASGVLYGTSQPFGITDL SG-ETSGVSDLSGQPSGLPGF--SGATSRVPDLVSGATSGSGESSGITFVDTSLVEVT-- P-ATFKEEEGLGSVELSGLPS---------------------------------GEADLS GK-SGMVDVSGQFSGT-----------VDSSGFTSQTPEFSGLPSG------IAEVSGEA SGAEIGSSL-ASGAYYGSGLPSGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILEISGA HSGAPDMSGDHSGFLDLSGLQ---------SGLVEPS-------GEPPGTPYFSRDFAST TDVSGESSAAMGTSREASGLP----------------EVTLIT-SEFV-EGVTEPTVSQE LGQRPPVTHTPQLFESSGEVSAAGDISGATPVLPGSGVEVSSVPESSNETSTHPEAGVGA SAAPEASREDSGSPDLSETTSAFHEADLERSS----------GLGVSGSTLTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------KASAAPEVSGESTTTNDVGTKAPG-------- ------------LP----------------SATP--------TASADRTEISGDLSG--H TSG------LGIVISTSIPESEWTQQTQRPVEAHLEIES---SSLLYSGEETHTVQTATS PT-DA-----SIPTSPEWKRES-------------------------------------- ESTAAAPARSCAEEPCGAG-TC-KETEGHVICLCPPGYTGEHCN---------------- ----------------------IDQEVCEEGWNKYQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRP NQPDNFFAAGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HMPTIRCQPSGHWEEPRITCTDPTTYKRRL QKRSSRHPRRSRPSTA----H >XP_019475050.1 aggrecan core protein [Meleagris gallopavo] -MTTLLLVFVCLQAITTAASA-----EF--SESSDGLEVKIPEQSPLRVVLGSSLNIPCY FNIPEEEDT-------SALLTPRIKWSKLSNETEIVLLVATGGKIRLNAEYKEVISLPNY PAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGVVFHYRAISTRYTLNFE KAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHLPRERCYGDKDEFPG VRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTGELYLA WKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPINQTGYPHPSSRYDAIC YSGDDFEAL----IPGQFTDEVGTELGSAFTIQTVTQTEVEL------PLPRNATEEEAR GSIA-TLEPM--EITATATELYEAFTVLPDLFTTSV-----TVETASPGEENVTREEVTG IWAVPEEVTTSVSDTAFTTEMAEVSSVEVAIGVTATPELESASPFTVEDHLVQVTAAPDV ----ALLPRQP--ISPTGVVFHYRAAT-SRYALSFVQAQWACLENNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKG EVFFATQPERFTFQEAQLYCASQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVS PRPGCGGDAPGVRTIYQHYNQTGFPDPLSRHHAFCFRAL----PSVEE-EGVTSHFE--- EEVMVTQVIPGV--EGIPSGEETTVETE--------LSAEPENQTA-WGTEVIPTDVSLL S--ARPSAFPPATVIPEETSTSASIPEV---SGEFPES---------------------- ------------------------------------------------------------ --------------------------------------------GEHPASGEPS------ -----------ASGA--PD--TSGEPT-----SGGFELSGEHSGIGESGLPSVDLQ--SS GF-------VPGESGLPSG----------------------------------DVSG-LP SG-T-------------------------------------------------------- ------------------------------------VDTSGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSAEEEISVSI-----SRIPEVSGMPSG---------------------------AESSG LHSG-------FSGEISGTELISGLPSG------------------------EESGLTS- -----GFPTVSLVD---------STLVEVVTAAPGRQEEGKGSIGVSGE-------GELS GFPSAE---WDSS-GARGLPSGAEASGEHSGVPELSGEHSGVP--GLSGEPFEVPELSGE HSGV--PELSGE----------HSGLP-ELSGEPLGVPELSGFPSGL-----------DI SG-EPSGIPEV----SGLVDV--SGLTSGV--------DGSGEISGITFISTSLQEVT-- T-PSTAEAEAKEILEISGLPS---------------------------------G--ETS GMVSGSLEVSGQPSGH-----------IDFGGSASGVLEMSGFPSG------AVESSGET SGVEVTSGL-ASG--EESGLPSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGF LSGDRGLSGEGSGAVQSSGLP---------SGTGDFS-------GEPSGIPYFSGDISGA TDLSGQPSAVTDISGEDSGLP----------------EVTLVT-SDLV-EVVTRPTVSQE LGGETAVT-FPYIFGPNGEGSASGDLSGGTSA--EGGIETSTAYEISGETSAFPETSIET STGQEISGEASAYPEISVETSTNLETSGETSAYPEISTETSTIQEVSGETSAFPEI---- ------------------------------------STETSTIQEISGETSAFPEIRIET STFQEISGETSAFPEIRIETSTSQEARSET--------------------SAFPEITIEA --------------------STVHETSGETSAFPEISIETSTVHEISGESSAFPEIRIET STSQEARGETSAFPEITIEASTIQEISGETSAFPEISIETSTVREISGETSAFPEIRIET STSQEARGETSAFPEITIETSTVHETSGETSAFPEISIETST-QEARGEGSAYPEVSIEA STIQEVSGESSAFPEISVETSTSQEARGETSAFPEIGIETSTAHESSGETPG-------- ------------LPAVSTDTAATSLASGEPSSAP--EKEIPDATS----HLIAGVSG--E TSV------PDVVISTSAPDVELTQEPRNTEETRLEIEP---STPAASGQETETAAVLDS PHLPATATAALHPASQEAIDAL-------------------------------------- GPT-TEDTDECHSSPCLNGATC-VDGIDSFKCLCLPSYGGDLCE---------------- ----------------------IDLANCEEGWIKFQGHCYR------HFEERETWMDAES RCREHQAHLSSIITPEEQEFVNSH---AQDYQWIGLSDRAVENDFRWSDGHSLQFENWRP NQPDNFFSAGEDCV-VMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRK KDRYEINSLVRYQCD--HGYIQR-------HVPTIRCQPNGHWEEPRISCINPSSYQRRL YKRSPWSRSRPG--VMHRPTH >XP_034795266.1 aggrecan core protein isoform X1 [Pan paniscus] -MTTLLWVFVTLRVITAAVTV-----ET--SDHDNSLSVSIPQPSPLRVLLGTSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNY PAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITVQTVTWPDMEL------PLPRNITEGEAR GSVILTVKPI-FEVSPSPLEPEEPFTFAPE-----------IGATAFPEVENETGE-ATR PWGFP------------------------------TPGLGPATAFTSEDLVVQVTA---- ------VPGQP--HLPGGVVFHYRPGP-TRYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDECYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISA-VPSPGEEEGGTPTSPSGV EEWIATQVVPGV--AAVPVEEETTAVPSRETTAILEFTTEPENQTE-WEPAYTPVGTSPL P--GILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSP----------- -------------------------------SEE------PFPSVEL------------- -----------------------------FPSEEPFPSKEPSPSEEPSALEEPYTPSPPV PSWTELPSSGEESGA--PD--VSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLD--SS GLISTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEG--SASGVG-DLSG-LP SG-EVLETSASGVGDLSGLPSGEVLETTAPGV-EDISGLPSGEVL--------------- ------ETTAPGV-EDISGLPSGEVL--ETTAPGV-EDISGLPSG-EV-LETTAPGV-ED ISGLPS-GEVLETTAPGVE-DISGLPSGE-------------------VL-ETT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APGVEDISGLPSGEVLETTAPGVEDISGLPSGEVLETTAPGV-EEISGLPSG-EVL -ETTAPGVEEISGLPSGEVLETTAPGV-EEISGLP-SG-EV------------------- ---------------------------------------------------------LET TAPGVEDISGLPSGEVL-ETTAPGVEDISGLPSGEVLETTASGV-EDISGLPSGE-VLET TAPGV-EEISGLPSGEVL-ETTAP------------------------------------ -----------------------GVEEISGLPSGEVL-ETSTSAAG-DLSGLPSGGEVLE ISASGV-ED--ISGLPSG-EVVETSASGIEDVSELPSGEGL-ETSASGV-EDLSRLPS-G E--------------------EVLEISASGFG-DLSGLPSGGEG-LETSASEVGTDLSGL PSGREGLETSA-----SGAEDLSVLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSG LPSG-------FSGEYSGVDLGSGPPSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVVTASTASELEGRGTIGISGA-------GEIS GLPSSE---LDISGRASGLPSGTELSGQASGSPDVSGEIPGLF--GVSGQPSGFPDTSGE T----------------------SGVT-ELSGLSSGQPGVSGEASGVLYGTSQPFGITDL SG-ETSGVPDLSGQPSGLPGF--SGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVA-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GK-SGMVDVSGQFSGT-----------VDSSGFTSQTPEFSGLPSG------IAEVSGES SRAEIGSSL-PSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGA HSGAPDMSGEHSGFLDLSGLQ---------SGLVEPS-------GEPPGTPYFSGDFAST TNVSGESSVAMGTSGEASGLP----------------EVTLIT-SEFV-EGVTEPTVSQE LGQRPPVTHTPQLFESSGEVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGA SAAPEASREDSGSPDLSETTSAFHEADLERSS----------GLGVSGSTLTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EASAAPEVSGESTTTNDVGTEAPG-------- ------------LP----------------SATP--------TASGDRTEISGDLSG--H TSR------LGVVISTSIPESQWTQQTQRPAETHLEIES---SSLLYSGEETHTVETATS PT-DA-----SIPASPEWKRES-------------------------------------- ESTAAAPARSCAEEPCGAG-TC-KETEGHVICLCPPGYTGEHCNIDIDECLSSPCLNGAT CVDAIDSFTCLCLPSYEGDLCEIDQEVCEEGWNKYQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRP NQPDNFFAAGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HMPTIRCQPSGHWEEPRITCTDPTTYKRRL QKRSSRHPRRSRPSTA----H >XP_023110702.1 LOW QUALITY PROTEIN: aggrecan core protein [Felis catus] -MTTLLLVFVTLRVITAASAI-----EA--SDPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLSPRIKWSRISKEKEVVLLVATEGQVRVNSAYQDKVSLPNY PAIPSDATLEIQNLCSNDSGMYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEDMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNVTEGEAR GNVILTVKPI-FDVSPTIPEPEEPFTFVPE-----------VGATAFPEAENRTGE-ATR PWGVPEE---------------------------STPGL-AFTAFTSEDHVVQVTAVPGA ----TEVPGRP--RLPGGVVFHYRPGS-ARYALTFAEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFVTRPEQFTFEEALAFCESHNATLASTGQLYAAWSGGLDKCYAGWLSDGSLRYPIVT PRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSA-APSPGEEEGGTATPS--V EDWIATQVVPGV--AAVPSGEETTTSPD--------FTTEPENQTE-WELAYTPVGTSPP P--GIPPTWPPTSAATEESTEGPSGTEVPSASEEPSPS---------------------- ------------------------------------------------------------ --------------------------------------EEPAPSEEPFPWEEPSTLAPPV PSGTELPGSGEASGV--PE--VSGDFTGSGEVSGRLDSSGQPSGEISSGLPSGDLD--SS GLTSAVGSGLPVESGLASGDEDRITGPSIPKV-----GGEGLET--SASGVG-DLSG-LP SA-EGPEVSASGVEVLSGLPSGEGPEVSASGV-GDLSGLPSAEGP--------------- ------EVSASGV-EVLSGLPSGEGP--EVSASGV-EVLSGLPSA-EG-PEVSASGV-EV LSGLPS-GEGPEVSASGVG-DLSGLPSAE-------------------GP-EVS------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----CLWSRVLSGLPSGEGPEVSASGVEVLSGLPSAEGPEVSASGV-GDLSGLPSA-EGP -EVSASGVEVLSGLPSGEGPEVSASGV-EVLSGLP-SG-EG------------------- ---------------------------------------------------------PEV SASGVEVLSGLPSAEGP-EVSASGVEVLSGLPSAEGPEVSASGV-EVLSGLLLEKKSL-- -ASGV-GDLSGLPSAEGP------------------------------------------ ------------------ESLASGVE-VSAGCFCRRS-EVSASGVG-DLSGLPSG-EGPE VSASGV-EV--LSGLPSG-EGPEVSASGVEVLSGLPSGEGP-EVSASGI-GDLSGLPS-G R--------------------EGLETSASGVG-GLSGLPSGIEGHPETSASGVG-DLSEF YSGGEGLETSA-----SGAEELSGLPSGKEDLIGSASGDLDLGRIPSGTPGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTISLVD---------TTLVEVVTATTASELEGRGTIGISGA-------GETS GLPLSE---LDISGAVSGLPSGAELSGQASGSPDTSGETSGFF--GVSGQPSGFPDISGG TSGL--FEVSGQASGF---SGETSAVT-ELSGLVSGQPDVSGEASGVLSGSGQPFGITDL SG-ETSGV----------PGV--SGATSGIPDLVPSAVSGSGASSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEAGLS GT-SGIMDVSGQSSGA-----------VDSGGFTSPPPEFSGLPSA------VAEVSGES SGAEIGSSL-PSGAYDGSGLASGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGIVELSGA HSGAPDVSGDHSGFLDLSGPR---------SGLVEPS-------GEPSSTPYFSGDFSGT VDVSGESSAATGTGGEASGLP----------------EVTLIT-SEFV-EGVTEPTVSQE LAQRPPVTHTPRLFESSGEASASGEISGATPTFPGSGV--GSVPESSSETPAFPEAGVGA SAAPEASGGASGSPDVSEATSTFPDADVEGGS----------GLAVSGSTSAFPEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PGEGLATPEAREEPTTTHDVGTEASG-------- ------------WA----------------SATP--------MASGDRTEIGGDLSG--H TSG------LDVVISTSVPESEWTQQTQRPAEAHLEIES---SSPLHSGEETQTAETATF PT-DA-----SIPTPPGGTDES-------------------------------------- AVT-VADIDECLSSPCLNGATC-VDAIDSFTCLCLPSYRGDLCE---------------- ----------------------IDQELCEEGWTKFQGHCYR------YFPDRESWVDAES RCRAQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHSLQFENWRP NQPDNFFVSGEDCV-VMIWHEKGEWNDVPCNYYLPFTCKKGTVACGDPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HVPTIRCQPSGHWEEPRITCTDPSTYKRRL QKRSSRPARRSRPSTA----H >XP_018865821.2 LOW QUALITY PROTEIN: aggrecan core protein [Gorilla gorilla gorilla] -MTTLLWVFVTLRVITAAVTV-----ET--SDHDNSLSVSIPQPSPLRVLLGTSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNY PAIPTDATLEIQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITVQTVTWPDMEL------PLPRNITEGEAR GSVILTVKPI-FEVSPSPLEPEEPFTFAPE-----------IGATAFPEVENETGE-ATR PWGFP------------------------------TPGLGPATAFTSEDLVVQVTA---- ------VPGQP--HLPGGVVFHYRPGP-TRYSLTFEEAQQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKNSSPGVRTYGVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISV-VPSPGEEEGGTPTSPSGV EEWIATQVVPGV--AAVPAEEETTAVPSRETTAILEFTTEPENQTE-WEPAYTPVGTSPL P--GILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEVPFPSEEPSP----------- -------------------------------SEEPFPSVRPFPSVEL------------- -----------------------------FPSEEPFPSKEPSPSEEPSASEEPYTPLPPV PSWTELPSSGEESGA--PD--VSGDFIGSGDVSGHLDFSGQLSGDRASELPSGDLD--SS GLTSTVGSGLPVESGLASGDEERIEWSSTPTVGELPSGAEILEG--SASGVG-DLSG-LP SG-EVLETSAFGVEEISGLPSGEVLETTAPGV-EDISGLPSGEVL--------------- ------ETTAPGV-EEISGLPSGEVL--ETTAPGV-EEISGLPSG-EV-LETTAPGV-EE ISGLPS-GEVLETTXPGVE-EISGLPSGE-------------------VL-ETT------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----APGVEEISGLPSGEVLETTAPGVEEISGLPSGEVLETTAPGV-EEISGLPSG-EVL -ETXAPGVEEISGLPSGEVLETTAPGV-EDISGLP-SG-EV------------------- ---------------------------------------------------------LET TAPGVEEISGLPSGEVL-ETTAPGVEEISGLPSGEVLETTAPGV-EDISGLPSGE-VLET TAPGV-EEISGLPSGEVL-ETTAP------------------------------------ -----------------------GVEDISRLPSGEVL-ETSTSAVG-DLSGLPSGGEVLE ISASGV-EDISISGLPSG-EVVETSASGIEDVSELPSGEGL-ETSASGV-EDLSRLPS-G E--------------------EVLEISASGVG-DLSGLPSGGEG-LETSASEVGTDLSGL PSGREGLETSA-----SGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSD LPSG-------FSGEYSGVDLGSGPPSGLP----------------------DFSGLPS- -----GFPTVSLVD---------STLVEVVTASTASELEGRGTIGISGA-------GEIS GLPSSE---LDISGRASGLPSGTELSGQASGSPDVSGEIPGLF--GVSGQPSGFPDTSGE T----------------------SGVT-ELSGLSSGQPGVSGEASGVLYGTSQPFGITGL SG-ETSGVPDLSGQPSGLPGF--SGATSGVPDLVSGATSGSGESSGITFVDTSLVEVA-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GK-PGMVDVSGQFSGT-----------VDSSGFTSQTPEFSGLPSG------IAEVSGES SRAETGSSL-PSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGA HSGAPDMSGEHSGFLDLSGLQ---------SGLVEPS-------GEPPGTPYFSGDFAST TNVSGESSVAMGTSGEASGLP----------------EVTLIT-SEFV-EGVTEPTISQE LGQRPPVTHTPQLFESSGEVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGA SAAPEASREDSGSPDLSETTSAFHKADLERSS----------GLGVSGSTLTFQEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------EASAAPEVSGESTTTNDMGTEAPG-------- ------------LP----------------SATP--------TASGDRTEISGDLSG--H SSR------LGVVISTSIPESEWTQQTQRPAETHLEIES---SSLLNSGEETHKVETATS PT-DA-----SIPASPEWKRES-------------------------------------- ESTAAAPARSCAEEPCGAG-TC-KETEGHVICLCPPGYTGEHCN---------------- ----------------------IDQEVCEEGWNKYQGHCYR------HFPDRETWVDAER RCREQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRP NQPDNFFAAGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQK KDRYEINSLVRYQCT--EGFVQR-------HMPTIRCQPSGHWEEPRITCTDPTTYKRRL QKRSSRHPRRSRPSTA----H >XP_021145604.1 aggrecan core protein isoform X1 [Columba livia] -MTTLLLVFVCLRIIAAAVAV-----EL--SDSSDGLEVKIPEQSPLRVVLGSSLNIPCY FNIPEEEDT-------SALLTPRIKWSKLSNGTEVVLLVATGGKIRLNSEYREVISLPNY PAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGIVFHYRAISTRYTLNFE KAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHWPRVQCYGDKDEFPG VRTYGVREPDETYDVYCYAEQMQGKVFYASAPEKFTFQEAFDKCHSLGARLATTGELYLA WKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLHA-NQTGYPHPDSRYDAIC YSGDDVETL----VPGQFIDERGSELGSAFTIQTVTQTEVEL------PLPRNATEEEAR GSIA-TLEPI--EITPPATELYEGFTVLPDLFATGV-----TAETAAPEEENVTRGDVTE VWAVPEEVTTVTLGTLITTQTAEMSSVEEVMEVTATPGLESASVFTVEDQLVRVTAAPGV ----GLLPEQP--ISPTGVVFHYRSAT-SRYAFSFVQAQQACLENNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKENSPGVRSYGMRPASETYDVYCYIDRLKG EVFFATQPEQFTFPEAQQYCESQNATLASVGQLHAAWKQGLDRCYAGWLADGSLRYPIVS PRPACGGDAPGVRTIYQHYNQTGFPDPLSRHHAFCFRAL----PPVEE-DGVTLFFE--- EDALATQVIPGV--EGVPSGEEVTVETE--------FATQPENQTA-WGTEVLPTDVSLL P--VSPSVFPPATIIPEETSTNASISEV---SGEMTES---------------------- ------------------------------------------------------------ --------------------------------------------GEHQVSGETSA----- --------SGWVPEV--PD--ASGEPT-----SGLFELSGEHSGIGESGLPSVDLH--TS GF-------LPGESGLPSG----------------------------------DLSG-VP SG-I-------------------------------------------------------- ------------------------------------VDISGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ TSGEEDVSVST-----SRTPEVSGLPPG---------------------------VESSG LPSG-------FSGEISGTELVSGVSSG------------------------EESGLAS- -----GFPTISLVD---------TTLEEVVTTVPERQEEGKGSIGVSGE-------GDLS GFPSAE---WDTSEGTHGLPSGAELSGEPSREP--------------------------- ----------------------------ELSGEPSGVPELSGLPSGL-----------DV SG-EPSGTHEV----SGLVDL--SGLTSGI--------DGSGEALGVTFVDTSLEEVT-- TIPSITRAEAKEILEISGLPS---------------------------------GGGDTS GMVSGSSDISGEPSGH-----------VDFGGSASGVLEMSGHPSG------VIDSSGEV SGVDVTSGL-LSG--EESGLTSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGF PSGDRGLSGEASGAILTSGFP---------SGTGDFS-------GEPSGIPYISGDTSGT TDLSGQSSAVTDASGEASGLP----------------EVTLVT-SDLV-QVVTIPTVSQE LGGETAVT-FPYGFGPSGGASASGELSGETSAWPESGMETSTAYEISGEASAFPETSIET STIQEISGETSAFPETSVETSTIHEISGETSAFPEFSTETSTIQEISGETSAFPEIIIET STSQEARGETSGYPEIIIETSTIQEISGETSGFPESSTETSTTQEISGETSAFPEIRIET STVQEISGETSAFPEIRIETFTSQEARAETSGYPEISIETSTVHETSGESSAFPEIIIET STVHEISGESSAFPEISIETSTVREISGESSAFPEISIETSTVREISGESSAFPEIRIET STNQEARGETSAYPEISIETSTVHETSGETSAFPQISIETSMVHEISGETSAFPEIRIET STSQEARGETSAFPEINIETSTVHEISGEASAFPEINIETQTSQEARGETFVYPETSIET STVQEVSGETSAFPEIRIETSTVQEVSGETSAFPEIRIETSTSQEARGETPAFSDTNRET STVHKTSGEASSLPASNVETAATSLARGEPSGAP-EEKEIPDTTSGAVTHSITGVSG--E ASV------PDFVISTSTPDVEPTQGHRNPEEAQLEIEP---SPPAVSEQQTETDAVLDN PHLLATATAVLPQVSQEAIDAL-------------------------------------- GPT-TEDTDECHSSPCLNGATC-ADGIDSFKCLCLPSYGGDLCE---------------- ----------------------IDLQNCEEGWTKFQGHCYR------HFEDRETWMDAEN RCRQYQAHLSSIITPEEQDFVNSH---AQDYQWIGLSDRAVENDFRWSDGHSLQFENWRP NQPDNFFSAGEDCV-VMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRK KDRYEINSLVRYQCN--QGYIQR-------HVPTIRCQPNGQWEDPRISCINPSNYQRRL YKRSPRSRSRLSGRAVHRPTH >XP_017922102.1 PREDICTED: aggrecan core protein [Capra hircus] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPD-FEVSPTAPEREEPFTFAPE-----------VRATAFPAVENRTGE-ATW PWAFPRE---------------------------STPGVGAPTAFTSEDLVVQVTLAPGV ----TEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKEACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGLRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSA-APSPGEEEGSTPTAGPEV EDWIVTEVRPGV--AAVPVGEETTAIPG--------FTVEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEEPFLPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEKPF------------PSEEPFPSEKPFPPEELFPSEKPIPSEEPF PSEKPFPPEEPFPSEKPIPSEEPFPSEKPFPPEEPFPSEKPIPSEEPFPSEEPSTLSAPV PSRTELPTSGEASGV--PE--VSGDFTGSGEISGHLDFSGQPSGESASGLPSEDFD--SS GLTPTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSRGEGPEV--SASGVE-DISG-LP SG-GEVH-----------------LEISASGV-EDLSGLPSGEEG--------------- ----HLEISASGV-EDLSGIPSGEGP--EVSVSGV-EDLSRLPSG-EG-PEVSASGV-ED LSRLPS-GEGPEVSASGVE-DLGVLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GPEVSASGVEDLSRFPSGEGPEVSASGV-EDLGVLPSG-EGH LEISASGVEDLSRLPSGEGPEVSASGV-EDLGVLP-SG-EGH------------------ ---------------------------------------------------------LEI SASGVEDLGVLPSGEGHLEISASGVEDLSRLPSGEGPEVSASGV-EDLGVLPSGEGHLEI SASGV-EDLSVLPSGEG------------------------------------------- ----------------HLEISASGVEDLSRLPSGEGHLEISASGVE-DLGVLPSGEGHLE ISASGV-ED--LSVLPSGEGHLEISASGVEDLSRLPSGEGHLEISASGV-EDLGVLPS-G E--------------------GHLEISASGVE-DLSRLPSGGEEHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DLSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGEASGLSSGAELSGQASGSPEISGETSGLF--GVSGQPSGFPDISGE TSGL--LEVSGQPSGF---SGEISGVT-ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGIPDLVSSAVSGSGESSGIMFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEAGLS GT-SGLVDVSGLSSGA-----------IDSSGFTPQPPEFSGLPSG------VTEVSGEA SGAASGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGT PSGAPDMSGDHLGSLDQSGLQ---------SGLVEPR-------GEPASTPYFSGDFSGA TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPITYTPQLFESSGEASVSGDV----PRFPGSGVEASPVPESSGETSAYPEAEVGA SAAPEARGGASGSPNLSETTSTFHEADLEGTS----------GLGASGSPSAFPEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTAFDVSVEASG-------- ------------SP----------------SATP--------LASGDRTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEETQTADTATS ST-DA-----SIPTSTGGTDDS-------------------------------------- EAT-TTDIDECLSSPCLNGATC-VDAIDSFTCLCLPSYQGDMCE---------------- ----------------------IDQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQK KDRYEINALVRYQCT--EGFIQR-------HVPTIRCQPSGHWEEPRITCTDPATYKRRL QKRSSRPLRRSRPSTA----H >XP_014377588.1 aggrecan core protein [Alligator sinensis] -MTTLLLVIVYLRVITAAFSV-----EL--SDNGDGLEVRIPEQSPLKVVLGNSLIIPCY FSDPIDYDT-------ISPLTPRIKWSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNY PAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQDTIEVIVKGVVFHYRAISTRYTLNFE KAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIHFPRERCYGDKDEFPG VRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTGELYLA WKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYV-NQTGYPHPHTRYDAIC YTGEDFEGL----VPENFTDETAGELGSAFTIQTVTRTEVEL------PLPHNVTEEEAR GSIA-TLGPI--DITPTASELYEGFTVTPGLFATGI-----TAETAFTEAENVTEEEATP VWAIPEEVTTWALETFYTSEAPEVSSVEEALGVTATPELESASAFTVEEQIVQVTAAPDI ----ALIPEQP--ISPTGVVFHYRPAT-NRYSLNFVQAQQACLDNNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGVRTYGMRPASEMYDVYCYIDRLKG EVFFATQPGQFTFQEAREYCESQNFTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVT PRAACGGDKPGVRTIYLNPNQTGFPDPLSRHHAYCFRAL----PSLQEVEGATPFFE--- EDLIATQVIPGV--EEVPSGEETTVETE--------LATGPENQTE-WGAEVFPTDISLL S--VSPSVFPPVSAIPEETSAEASVSGV---SGDISAS---------------------- ------------------------------------------------------------ --------------------------------------------GEPQISGEPTI----- --------SGWVSGA--PD--VSGEPA-----SGIFEPSGEPSGIGESGMPSADLD--IS GL-------LSGESGLPSG----------------------------------DVSG-MP PV-I-------------------------------------------------------- ------------------------------------IDVSGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSGEEDLAVSA-----SGIPDISGMPSGEE---------------------ISELPEISG LPSG-------FSGEVSGVELTSGLPSG------------------------EESGLPS- -----GIPTVYIDH---------TTLVEVVTTAAEREQEGKGVIGVSGE-------GDLS GLPSAE---WDISGKISGFPSGADISGEPSGIPDISGAPSGIP--DISGLPSGV------ ----------------------------DISGMPSGIPDISGLPSGI-----------DI SG-APSGIPDI----SGFVDL--SGLVSGG--------DESGEPSGITFINASVVEVT-- T-PSITEAEAKEILEISGLPS---------------------------------GEEDIS GAVSGILDVSGLPSGL-----------VDFSGDVSGMPEISGLPSG------IPDISGEI SGVEVSSGQ-PSGVYDYSGLQSGLPTISLVDTTLVEVVTQTSVAQEAGEGPSGVLEISGL PSGERETSGEVSGMVDISGLP---------SGTVDIS-------GEPSSVPYFSGDISGV TDLSGLTSAVTEVSGEESGLP----------------EVTLIT-SDLE-EVVTKPTVSQE LGGETAVT-VPHIFEASGDASASGESSAETSALPEISPETSTAYEISGETSAFPEAATES STAREISGETSALPEISIETSTVHETGGETSAFPEISIETSTVHETSGETSALPEI---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------HIETATVQEASGETSALPEISIETATVGGTSGETSALPEISIET ATVGGTSDETSALPEISIEAATVGETSDETSALPEISIEAATVGETSDETSALPEISIEA ATVGETSDETSALPEISIETATVGGTSDETSALPEISIEAATVGGTSDETSALPEISIEA ATIGETSDETSALSEISIETATAGGTSDETSALPEISIETATVHETSSETST-------- ------------FPETSTDTSGISLVSGESSGTPEERREISTDTSGTHTHTIPDISG--E TSA------PDIVISTSIPDVELTQEPKGPEEAQLEIES---STPMVSGQETETAAVLET LLISPTATAILPQVSQEATDVPRLTAEVAPKT---------------------------- ----------CDENPCGAG-TC-QERDGGITCLCPPGYMGDRCD---------------- ----------------------IDLEDCEVGWTKFQGHCYR------HFEERETWVDAET RCREHQAHLSSIITPEEQDFVNNH---AQDYQWIGLSDRAVEHDFRWSDGNSLQYENWRP NQPDNFFATGEDCV-VMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRK KDRYEINSMVRYQCN--QGFIQR-------HVPTIRCQPNGHWEEPRIACINPSTYQRRL YKRSSRNRSRTNGRAVQRPTH >XP_019333446.1 PREDICTED: aggrecan core protein isoform X1 [Alligator mississippiensis] -MTTLLLVFVYLRVITAAFSV-----EL--SDNGDGLEVRIPEQSPLKVVLGNSLIIPCY FSDPIDYDT-------ISPLTPRIKWSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNY PAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQDTIEVIVKGVVFHYRAISTRYTLNFE KAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIHFPRERCYGDKDEFPG VRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTGELYLA WKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYV-NQTGYPHPHTRYDAIC YTGEDFEGL----VPENFTDETAGELGSAFTIQTVTRTEVEL------PLPYNVTEEEAR GSIA-TLGPI--DITPTASELYEGFTVTPGLFATGI-----TAETAFTEAENVTEEEATP VWAIPEEVTTWALETFYTSEAPEVSSVEEALGVTATPELESASAFTVEEQIVQVTAAPDI ----ALIPEQP--ISPTGVVFHYRPAT-NRYSLNFVQAQQACLDNNAVIATPEQLQAAYE AGFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGIRTYGMRPASEMYDVYCYIDRLNG EVFFATQPGQFTFQEAQEYCESQNSTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVT PRAACGGDKPGVRTIYLNPNQTGFPDPLSRHHAYCFRAL----PSLQEVEGATPFFE--- EDLIATQVIPGV--EEVPSGEETTVETE--------LATGPENQTE-WGTEVFPTDISLL S--VSPSVFPPVSAIPEETSAEASVSGV---SGDISAS---------------------- ------------------------------------------------------------ --------------------------------------------GEPQISGEPTI----- --------SGWVSGA--PD--VSGEPA-----SGIFEPSGEPSGIGESGMPSADLD--IS GL-------LSGESGLPSG----------------------------------DISG-MP PV-I-------------------------------------------------------- ------------------------------------IDVSGL------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ PSGEEDLAVSA-----SGIPDISGMPSGEE---------------------ISELPEISG LPSG-------FSGEVSGVELTSGLPSG------------------------EESGLPS- -----GIPTVYIDH---------TTLVEVVTTAAEREQEGKGVIGVSGE-------GDLS GLPSAE---WDISGKISGFPSGADISGEPSAIPDISGAPSGIP--DISGLPSGV------ ----------------------------DISGMPSGIPDISGLPSGI-----------DI SG-APSGIPDI----SGFVDL--SGLVSGG--------DESGEPSGITFINASVVEVT-- T-PSITEAEAKEILEISGLPS---------------------------------GEEDIS GAVSGILDVSGLPSGL-----------VDFSGDVSGMPEISGLPSG------IPDISGEI SGVEVSSGQ-PSGVYDYSGLQSGLPTISLVDTTLVEVVTQTSVTQEAGEGPSGVLEISGL PSGERETSGEVSGMVDISGLP---------SGTADIS-------GEPSSVPYFSGDISGV TDLSGLTSAVTEVSGEESGLP----------------EVTLIT-SDLE-EVVTKPTVSQE LGGETAVT-VPHIFEASGDASASGESSGETSALPEISPETSTAYEISGETSAFPEAATES STAREISGETSALPEISIETSTVHETSGETSAFPEISIETSTVHETSGETSALPEI---- ------------------------------------------------------------ ------------------------------------------------------------ ----------------HIETATVQEASGETSALPEISIETATVGGTSGEISALPEISIET ----------------------------------------ATVVETSDETSALPEISIEA ATVGETSDETSALPEISIETATVGGTSDETSALPEISIETATVGGTSDETSALPEISIET ATVHE--------------------TSSETSTLPEISIETATVHESSGETST-------- ------------FPETTTDTSGISLVSGESSGTPEERREISTDTSGTHTHTIPDISG--E TSA------PDIVISTSIPDVELTQEPKGPEEAQLEIES---STPMVSGQETETAAVLET LLISPTATAILPQVSQEATDVPRLTAEVAPKTCDENPCGAGTCQERDGGITCLCPPGYMG DRC-DIDIDECHSSPCLNGATC-VDGIDSFKCLCLPSYGGDLCE---------------- ----------------------IDLEDCEVGWTKFQGHCYR------HFEERETWVDAET RCREHQAHLSSIITPEEQDFVNNH---AQDYQWIGLSDRAVEHDFRWSDGNSLQYENWRP NQPDNFFATGEDCV-VMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRK KDRYEINSMVRYQCN--QGFIQR-------HVPTIRCQPNGHWEEPRIACINPSTYQRRL YKRSSRNRSRTNGRAVQRPTH >XP_020765043.1 aggrecan core protein [Odocoileus virginianus texanus] -MTTLLLVFVTLRVIAAAISV-----EV--SEPDNSLSVSIPEPSPLRVLLGSSLTIPCY FIDPMHPVTT---APSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNY PAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFD RAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPG VRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLA WQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHA-NQTGYPDPSSRYDAIC YTGEDFVD-----IPENFFGVGGEE---DITIQTVTWPDVEL------PLPRNITEGEAR GNVILTAKPE-FEVSPTVPEPEEPFTFVPE-----------VRATAFPAVENRTGE-ATR PWAFPGE---------------------------STPGLEAPTAFTSEDLVVQVTLAPGA ----AEVPGQP--RLPGGVVFHYRPGS-SRYSLTFEEAKQACLRTGAVIASPEQLQAAYE AGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEG EVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVT PRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSV-TPSPGEEEGSTPTAGPDV EDWIVTQVGPGV--AAVPVGEETTATPG--------FTVEPENKTE-WELAYTPAGTFPL P--GIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPPEEPFPSEKPFPPEELF PSEKPFPSEKPFPSEEPF------------PSEK-------------------------- ------------------------------------PSEKPFPSEEPFPSEEPSTLSAPV PSRTELPSSGEASGV--PE--VSGDFTGSGEISGHLDLSGQPSGESASGLPSEDLD--SS GLTSTVGSGLPVESGLPSGEEERITWTSAPKIDRLPSGGEGPEV--SASGVE-DISG-LP SG-GEGH-----------------LEISASGV-EDLSRLPSGEGP--------------- ----------------------------EISASGV-EDLSGLPSGGEVHLEISASGV-ED LSRLPS-GEGPEISASGVE-DLSGLPSGE------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------GPEVSVSGAEDLSGLPSGEGPEVSVSGA-EDLSGLPSG-EGP -EVSVSGAEDLSGLPSGEGPEVSVSGA-EDLSGLP-SG-EG------------------- ---------------------------------------------------------PEV SASGVEDLSR--------------------LPSGEVPEVSASGV-EDFSRLPSGEGP--- ------------------------------------------------------------ ------------------EISASGVEDFSRLPSGEGP----------------------- ----------------------EVSASGVEDLSRLPSGEGP-EVSASGV-EDLGILPS-G E--------------------GHLEISASGVE-DLSRLPSGGEDHLETSASGVG-DLSGL PSGREGLEISA-----SGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASG LPSG-------FSGEYSGVDLGSGPSSGLP----------------------DFSGLPS- -----GFPTVSLVD---------TTLVEVVTATTAGELEGRGTIDISGA-------GETS GLPFSE---LDISGGASGLSSGAELSGQASGSPDISGETSGFF--GVSGQPSGFPDISGE TSGL--L---------------------ELSGLPSGQPEISGEASGILSGLGPPFGITDL SG-EAPGIPDLSGQPSGLPEF--SGTTSGVPDLVSSAMSGSGESSGITFVDTSLVEVT-- P-TTFKEEEGLGSVELSGLPS---------------------------------GEADLS GT-SGLVDVSGLSSGA-----------IDSSGFTSQPPEFSGLPSG------VTEVSGEA SRAESGSSL-PSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGA PSGAPDMSGDHLGSLDQSGLQ---------SGQVEPS-------GEPASTPYFSGDFSGT TDVSGESSAATSTSGEASGLP----------------EVTLIT-SELV-EGVTEPTVSQE LGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPKAEVGA SAAPEASGGASGSPDLSETTSTFHEADLEGAS----------GLGASGSSSAFPQG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------PTEGLATPEVSGESTTTFDVSVEASG-------- ------------SP----------------STTP--------LASGDKTDTSGDLSG--H TSG------LDIVISTTIPESEWTQQTQRPAEARLEIES---SSPVHSGEESQTADTATS PT-DA-----SIPTSAGGTDDS-------------------------------------- ETT-TT------------------------------------------------------ -----------------------DQKLCEEGWTKFQGHCYR------HFPDRATWVDAES QCRKQQSHLSSIVTPEEQEFVNNN---AQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYQLPFTCKKGTA----------------- -----------------------------------------------------ATYKRKL QKRSSQPLRRSRPSTA----H >XP_040198337.1 aggrecan core protein isoform X1 [Rana temporaria] -MTTLLLVFVCLRVIAAAISV-----EF--SDHANTLSVSIPEEAPLNVLLGHSVTIPCY FINAVEHLTV---APSTAPLSPRIKWSRHNKGHETVLLVATNSQIRVTEAYKGRISLPNY PLIPTDVSLEIVNLLSSDSGVYRCEIMHGIEDSQDTVTLNVKGIVFHYRAISTRYTLDFE NAKKACIQNNAVIATPEQLQSAYDDGYHQCDAGWLSDQTVRYPIHNPREPCYGDKEMFPG VRTYGVRETDETYDVYCYAEHMEGEVFYATSPGKYTFHEAEKQCQNLGARLATTGELYLA WQTGMDVCSAGWLADRSVRYPISYKRPNCGGNLVGVRTVYLHP-NQTGYPDPLSRYDAIC YKDD-------------------AE---NITIQTVTQPGLEL------IFQRNVTEEEAR GSIA-TLEGL--DFTLTPSE--DSFTATPVFPGTPLS--PDLVPTEAP-LENITDD-GLQ LWL---E------------------------NVTAVPSVEATG--TVEGEVVPVTAAIDA -----AQPGKP--ISETGVVFHYRAGS-SRYSLNFNQAKQACLNNHAAITTPAQLQAAYE AGFDQCDAGWISDQTVRYPIVQPRENCNGDKNGFPGVRNYGVVNPDEQYDVYCYIDKLRG QVFFATQPDHFTFQQAQEFCESKNATLASTGQLYSAWKSGFDKCRAGWLSDGSVRYPIVT PRKVCGGDQSGVRTVYLYANQTGFPDPLSKYNAFCFR------PSLFEEEEEVPGTPSIE EEIIATKLYPVV--EGLPSGEEITVETV--------TATEFENETDFWLLNATALPTVEL EI-VRPSAIPPVAAVPEDVSGEASVSGA---SGIPSGE---------------------- ------------------------------------------------------------ ------------------------------------------------VSGEP------- --------SGEVSGV--PD--ISGEPSASGLVSG--EGSGEPSGI--SGFSSGDISA--- -------------SGLPSG----------------------------------EVSGEIP SG-E-------------------------------------------------------- ------------------------------------IDTSGLP----------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------------SGF PSGDELISGSA-----SGFPDISGLTSA----------------------------DMSG LPSGD------VSGEASGVELVSGLPSGFESGLSSGDFSGLHSGDFSGLPSGDFSGLPS- -----GFPTILHVD---------TVWTEGITKSPDTEAEGKGTTEFSAS-------GDIS GLPSTD---F------SGLASGLELSGEPSGL-DFSGRPSGFF--EVSGEVSGI-DMSGF SSGIPLEESSGDISGI---SGLPSGISGEESGDISGAKEFSGDISGIFSG--------DL SGISGSGLIDFSGEIDISGEI--SGASGDISGVSSGTFDESGESSGVTLIDGILVEST-- R-PSEKEEEGKGSVEESGLFSGDFSGEISGISGISGEISGDIDASGLISGELPSGELDIS GLTSGIIDISGEASGAGFI-SGLPSGIDDISGEASGAGFISGLPSG------IDDISGEA SGAGFISGL-PSGIDDISGLTSGFPTISHIDLTLVEVPTIGPDTEEAGQGPSGVFEISGF PSGE--TSTEASGIIDLSGFP---------SG--ETS-------TEASGIIDLSG-FPSG TQESGDGSGI-----HTSGIP----------------DIKLIT-DDLI-EAVTEPTVSQE LAG---VT-SPYII----DASASGDISGEGPL---------TIPDISGEPSGIPL----- ---------------------------------------------TSGEPESFVEG---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------STEAST---------------------------- ------------------------------------------DISGHQTSSANDVSG--E TSV------PDIVISTSQPESEISLDQKEPEEAKKDTEL---SAS-ASGDITEDVPLEVV TP-APLLE-AKPQAIPDVTEVEGIVG-----TCADINCGAGACVERDGRVHCQCLPGYGG DNC-EIDIDECLPSPCVNGATC-VDGIDSFKCLCLPSYGGDLCQ---------------- ----------------------IDIEVCDEGWTKFQGHCYQ------HFSNRETWVDAEN TCRSHQSHLSSILSSEEQEFVNGN---AQDYQWIGLNDKTVENDFRWSDGNPLQYENWRP NQPDNFFATGEDCV-VMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVENAYTLGRT KERYEITSLVRYQCN--QGFLQR-------HVPIIRCLSSGQWEEPRIQCINPSTYRHR- --RSPRRRPKSADKDTQKKAH >tr|F1R511|F1R511_DANRE Aggrecan b OS=Danio rerio OX=7955 GN=acanb PE=4 SV=3 -GTSLYLI----------------------CLENSTLSVSIPVEQPLRPLLGGSMVIPCY FQDITLQDPGTLTSPTNAPLSQRIKWSHIHKGKISLILVATEGQVQVETEYLDRVHLVNY PMVPSDATIEISELRSHDSGTYRCEVMQGIDDNYDSVEMQIQGIVFHYRAISTRYTLTFE MAKAACIQNSAVIATPAQLQAAYDDGFHQCDAGWLSDQTVRYPIHEPREPCYGDKDNFPG VRTYGVRDVNETYDVYCFAEKMSGRVFYSMSVEKFTFADAEDQCAKLGAQLATTGQLYLA WKTGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFP-NQTGYPYPDSRYDAIC YEED------------------------KVLIKTTPFPEIYTTTDSSDYTEQVTTEGEVR GQIL-TDEPF--NTTSTESPLSPPLNITDV------------------------------ ----------------------------------------------EEDIINVATAPPSL E---HAIPSINVTAKIKGVVFHYRAES-GRYAYTYEEAQDACQKLGAVIATPELLQAAYE AGLHQCSAGWLQDQTVRYPIVHPRKKCSGDSEDVPGVRSYNVRPAHEQYDVYCYMDQIKG EIFHVSSLAGFTYYEAVAHCRKLSSTLASTGELYAAWNQGFHKCSPGWLADRSVRYPVGS PDFDCGGNKTGVQTIYAQPNQTGSPHPYSRYDAYCFKGITA------------------- -QCVFVQV---------------------------------------------------- -------FHPIVPPLFVDMSGSGSG----------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ --------SGYASAS------TSG--------SGSDSASGSASGV--PDSSSGYISG--- -------------SGIASG----------------------------------SASG--- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --SG-------QSGDGSGFLV-----------R-------------------YQEGTD-- -----------------------ALMWS--SASGSASEAKDG------------------ --------------------SGSGIII-TSGI---------------------------- ----------------------QSGDQ-ESGEESGHFAVASGLPSGLGSGI-------SG SG--------TSGFFSG------------------EESSGSGF-FSVSFVDTKMIDLT-- A-RAFGEQ------ELSGFYT---------------------------------AE---- ----------------------------------------SGFPSG----------SGSF SGFETGSAI-------------------------------------------GFESNSAF GSGSGFETGSAIGFESNSASAFGSGSS---SGFESSSAFGFGS-GSASG---FGSGIASG IESS--PASAF-GSGSASGF---------------------------------------- -----------------GSSSAIGLESS-------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------SASGFKSVSVTGTSG--- -------------YPNHP------------------------------------------ ------------------------------------------------------------ ----SAPFDPCDPNPCGQGLCS-LQDGVAL-CQCHSGFSGENCS---------------- ----------------------MLVQGCAEGWMEFMGSCYI------HFDERETWTSAEQ HCQELNSHLVSISSQQEQEFVKTQ---AQDYQWIGLNDKDVQNEFRWTDGSPLEYENWRP NQPDNYFSTGEDCV-VMIWHENGQWNDVPCNYHLPFTCKSGPVTCTTPPEVQNARMLGNS KDRYPVNSFIRYQCN--SGFTQR-------HLSVVRCLPDGQWEKPRVECIRGI-ENNRL RKRSLYIRPKAVNSRTWRKVL >tr|E7F537|E7F537_DANRE Aggrecan a OS=Danio rerio OX=7955 GN=acana PE=4 SV=3 -MLSLLLLSMCLWVFSATASF-----DYIDTEPESPLRVSIPNELPLRPLMGDTLVLPCY FQDNTVNDPG---APTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGY PMTPTDASIKITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFE KAKAACIQNSAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPG VRTYGVRDVNETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLA WKGGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFP-NQTGYPHPDSRYDAFC YSETGDEGSGFFPLDLELTTDGDNG---VLTVDTITESH-TV------ISKPASTESEVQ GEVV-TYKPS--VTTSVENPY-TALDISHV------------------------------ ---------------------------------------------LPSPPTSSVEKDPDF GSGLSQSNKTEDTMSATGVVFHYRGGNCSRYPFGFVEAQLACKSIGAVIASAQQLQAAYE AGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRSYGLRPADERYDVYCYVDKLRG QVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQGFDKCRAGWLLDRSVRYSINI PRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKEDL-------------------- ---------------DLPLNESESQETV----------------TEEKIVSISSHPAL-- ---HRPEGTPIIAPSPTEPSGTEESVAS-------------------------------- ------------------------------------------------------------ ------------------------------------------------SSGDLL------ -----------SSGS--GDQ-----------PSGSSVSSGDSSGT--SSTDDLLTSG--- -------------SGDQSG-----------------SGSS------VTSG---DYSG--- ----------------------------ASGT-DSLFS---------------------- ---------------------------------------SGSGDR--------SSG---- -----------SFSSSG---DFSG------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------ASGT-DDLLG---------- ------------------------------------------------------------ ----------------------------------------SGSGEQ-------------- ------------------------------------------------------------ ---------------------------PSGSF-----------------------VSSGD FSGA------------SGSGDMSS---------------------------------GSG SSSG--------SGSGLDILV-------------------------------TFSGID-- -----------------------TVFSGVGSTSGQLEEAGEGSTEILTFQL--------- ---------DQISGSGSGLGSGSGYSSEESGS---------------------------- ----------------------TSDLS-SSSGESGESGDLSGISSGSGFSE-------ES SG--------FSGFASGIFP---SGGSSDI-----SFIDGSG----IIMVDRPWMKIS-- S-FLTEQELGSGQVDFS-------------------------------------GSGLFS G---------------------------------------SGVSGD------ISGLSGEI SGS--------------SGDSSG----ISSDISGMSGDISGMSGDISGISGD-ITGMSGD LSGMS--SSDHSGSG--SGLA-FSGVTFLGSGFTDLT-EQSRE-QEASGLVFFGSGEGSG FRSGGYAI----ESGERSGDSASS-------------DVIFFSNNDMV-EMSNKPLQGME LGR--------------GEVEYSGTVR--------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------LSSGSGDDQSVFISG--H EW-----------IPVTANTPSVKSTDPPPAELFDQGPSDLYSDTAGHLGPYLKPEEIIN NL-DA----VPLAALSSTTETASLQR---P-----------AVVER-------------- PAV-NDYLNPCEPNPCGAGVCS-VKDGVGL-CHCPPGLHGEECQ---------------- ----------------------FDSHSCEKGWTKFQGNCYL------HFSKRETWLDAEQ RCRDLNAHLVSINTPEEQAFVNSN---AQDYQWIGLNDKTVENDFRWSDGTQLQFENWRP NQPDNYFNSEEDCV-VMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGNK KERYQVNSIIRYQCS--ENFTQR-------HPPVIRCMADGQWEKPKVQCIPKVKFG--L HDKSVHHSHKARTALEKQ--L >XP_038065741.1 fibropellin-3-like [Patiria miniata] ------------------------------------------------------------ -------------MAKLCPKSGYTNWG--------------------------------- PGLPDN---------------------YGYED---------------------------- -----C--------------AYMDPGFYGAGGNW-------------------------- ------------NDVWCF------------------------------------------ ------------------QY-----------------------------------YNYIC KK---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----RITPSSCDDKPCQNSGVCETDGTGGYQCKCKAGYTGKTCQ---------------- ----------------------ED-NYCQSGWNHYGDFCYRFSDEYLHFDDRHTWQGALA RCQSDGANLVSIHSKDESNFIFDHMGYSRGRFWIGLTDQEREGFFKWSDGTKLDFINWSP RIPDN--AGNEDCAHIDSVYFGSQWSDVWCGQIYGYVCKKAAED------IDECKSQPCQ NDGTCVDLINDYRCDCVAGYDGKDCENNIDECALTTCL-------PGFVCVDGINSCCCM ATKSMT--------------V
BMGE Cleaned alignment of selected proteins >sp|P16112|PGCA_HUMAN Aggrecan core protein OS=Homo sapiens OX=9606 GN=ACAN PE=1 SV=3 MTTLLWVFVTLRVITAAVTVSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFAEVENETGEATRPWGFP---TPGLGPATAFTSEDLVVQVTA------VPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIVTQVVPGVAAVPVEEETTAVPSFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGLETTAPGVEDISGLPSGEVLDISGLPSGETTAPGVEDISGLPSGLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGVLETAAPGVEDISGLPSGGEVLETAAPGVEDISGLPGEVLETTAPGVEEISGDEISGLETSTSADVSELPSGEGLETSASGVEDLSRLPSEVLEISASGFGDLSGLPSGGEGLETSASEVGDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGET----------SGVTELSGLSSGQPGISGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVATTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLIEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITEGVTEPTISQELGQRPPVTHTPQLFESSGKVSTAGDISGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEANLERSSGLGVSGSTLTFQEG--EASAAPEVSGESTTTSDVGTEAPGTASGDRTESGDLSGLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTSIPASPEWKRESAPARSCAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPQITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_043345769.1 aggrecan core protein isoform X7 [Cervus canadensis] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPVGEETTATPGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSASGVELEISASGVEDISGLPSGGEVDISGLPSGEISASGVEDLSGLPSGLEISASGVEDLSVIPSGEGPEVSVSGVEDLSGLPSGGPEVSVSGVEDLSGLPSGGEGPEVSVSGVEDLSGLPGEGPEVSASGVEDLGVEDLSRLETSTSEDLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSRGEDLETSASGVGDLSGLPSGRDGLEISASGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGILEISGQISGMTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSREPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGASAAPEASGGASGSPDLSETTSTFHEADLEGTSGLGASGSPSAFPQGPTEGLATPEVSGESTTTFDVSVEASGLASGDKTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSAGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRTLRRSRPSTAH >KAB0352492.1 hypothetical protein FD754_017349 [Muntiacus muntjak] -------MVNLQ----ALLEFEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGEKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPIGEETTATPGFTVEPENKTEWELTYTPAGTFPLPG--------------------------AHRRPFCNEEPFPSEEPSTLSAPVPSRTELPSSGEASGVVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPSESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSASGVELEISASGVEDISGLPSGGEVDLSRLPSGEISASGVEDLSGLPSGLEISASGVEDLSVIPSGEGPEVSASGVEDLSRLPSGGPEVSASGVEDLSGLPSGGVGPEVSASGVEDLSRLP----------------EDLSRL------DLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSGGEDLEPSASGVGDLSGLPSGREGLEISASGAADLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGETPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGATDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGIETSSVPESSGEMSAYPEAEVGASAAPKASGGAFGSPDLSETTSTFHEADLEGTSGRGASGSPSAFPQGPTEGLATLEVSGESTTTFDMSVEASGLASGDKIDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSAGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSHPSTAH >KAB0369135.1 hypothetical protein FD755_019140 [Muntiacus reevesi] -------MVNLQ----ALLEFEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPIGEETTATPGFTVEPENKTEWELTYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVVSGDFTGSGEISGHLDVSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEVSASGVELEISASGVEDLSRLPSGEGP--------EISASGVEDLSGLPSGLEISASGVEDLSVIPSGEGPEVSASGVEDLSRLPSGGPEVSVSGVEDLSGLPSGGEGPEVSASGVEDISRLPGEGPEVSASGVEDL--------------DLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSGGEDLETSASGVGDLSGLPSGREGLEISASGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQGPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSRLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSRLLEVSGQISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGETPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTMTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGATDSSGFTSQPPEFSGLPSGVTEVSGEAYRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQATTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAAMSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYSPQLFESSGEASASGDV----PRFPGSGIETSSVPESSGEMSAYPEAEVGASAAPEASGGAFGSPDLSETTSTFHEADLEGTSGLGASGSPSAFLQGPTEGLATPEVSGESTTTFDVSVEPSGLASGDKTDSGDLSGLGIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQIADTATSPTSIPTSAAGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSRPSTAH >OWK08890.1 ACAN [Cervus elaphus hippelaphus] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVK-------AISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPVGEETTATSGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWTSAPEVDRLPSGGEGPEVSASGVELEISASG-----------------------------------------------------------------------------------------------------------------------------------------DLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSRGEDLETSASGVGDLSGLPSGREGLEISASGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGILEISGQISGMTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSREPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGASAAPEASGGASGSPDLSETTSTFHEADLEGTSGLGASGSPSAFPQGPTEGLATPEVSGESTTTFDVSVEASGLASGDKTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSAGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRTLRRSRPSTAH >KAF4017792.1 hypothetical protein G4228_009467 [Cervus hanglu yarkandensis] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVAPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPVGEETTATPGFTIEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEG--------------------------------------------------------------------------------------------------------------------------------L---------------------------EISASGVEDLSGLPSGLEISASGVEDLSVIPSGEGPEVSVSGVEDLSGLPSG----------------------------------------------------------------DLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSRGEDLETSASGVGDLSGLPSGRDGLEISASGAGDLSGLISGKEDLTESASGDLDLGRIPSVTLGSGQAPEASGLPSGFRGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGILEISGQISGMTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSREPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFETSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPEAEVGASAAPEASGGASGSPDLSETTSTFHEADLEGTSGLGASGSPSAFPQGPTEGLATPEVSGESTTTFDVSVEASGLASGDKTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSAGGTDDST--------------------------------------DQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHTLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRTLRRSRPSTAH >XP_041442785.1 aggrecan core protein isoform X2 [Xenopus laevis] MTTLLLVFVCLRVIAAAISVTDHHNTLSVIIPLDLPLNVQLGHSLTIPCFFINALDGVTVAPSTAPLTPRIKWSKHVKGKETVLLVATDGHVRVNEAYNGRVSMPTYPLAPTDVSLEISNILSNDSGTYRCEVMHGIEDSQATVEVNVKGVVFHYRAISTRYTLDFEKAKKACIQNSATIATPEQLQAAYDDGYHQCDAGWLSDQTVRYPIHNPREACYGDKDMFPGVRTYGVRETDETYDVYCYVEDMQGEVFYATSPEKFTFDEAEKQCKSLGARLATTGELYVAWKSGMDVCSAGWLGDRSVRYPISIARPNCGGNLVGVRTVYLHPNQTGYPNPLSRYDAICYKAGP-------------DEDITIQTITQPSLEIIIPRNDTEEEARGSIA-SLEPT-NFTLTPTDLEEFFTATPELVLTEGP-FENVTEE-----VFPLEFSEGPEFNATTSLEEEIVPVTAAPAE-VEPEKHIAKTGVVFHYRAASSRYSLNFTEAKKACLVNNAIIATPAQLQAAYEAGFDQCDAGWISDQTVRYPIVTPRENCHGDKNGFPGVRNYGVVNPAARFDVYCFIDKLHGEVFFATQPDQFTFQEANEFCDEQNATLASTGQLYVAWKLGLDKCRAGWLSDGSVRYPIVTPRKACGGDIPGVRTVYLHANQTGFPDPLSKYHAFCFR------------EEIPEIPSIKEEVIVTQVVSELETLPSGEGPTAEIETTTDFENQTDWMANVTESPTIEPSVSPSVVPIVSPAPEDISGETSGIGS-AISGEPSGV----PSGEV---------------SGDVSGALSGQPSGTEE-SG-FPSGTDISGV--SGLPSGDVSVSGDI----------SGDVSG------------------------------------------------------------------PDISGLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------SGFPSGAEDISGQVSGFPDISGLSSVP--------------------------IETSGLSSGISGSASGIEIISGFSSGIEDVSGIASGFPTITHVDTTWVESVTKPTETELEGKGEIEFSASGDLSGLES---------SGDLSGFDLSGVTSSVIESSGDISGFIDISGEPSGMIDLSGEVSGVTDISGEASGVLDFSGELSG---LSGESSGIISVSSGYSGDIGISGEASGIREISGELSGVPDISGLGSGILEI----------PSGVILIDQSLKELSPPKKEEEGKGSVGISGFYSGDVDSSGDSGILDVSGEPSGLIDISGFMS-----GGIPSGLSDISGAVSGSEYVSGLQSGFDDVSGV----PTVSHIDFTLKEPPTQGPDTQEAGGSPSVILEFSGIASGETLPSGTHEGSLESSGI---------------YTSG--------------------------SVTLITEAITKPAVSQELGG---VT-FAYTI----ETSASGDI--------------------GTETSATHE----------------------------------------TSGKQETTLEGSTE-----------------------PSSGHITFAPESSG----------ETSESETTHAPEEAQQETELVTSVASGEVTDEPTIETASP-----PITIESE--IGSCADQPCGAG-TCTEKEGRIYCACPAGFGGDLCNIDLEVCEDGWTKFQGHCYKHFSERETWVDAENVCRYHQSHLASILSPEEQEFVNSNAQDYQWIGLNDKTIENDFRWSDANPLQYENWRPNQPDNFFTTGEDCVVMIWHERGEWNDVPCNYHLPFTCKKGTVACSDPPAVQNAYTLGKKKVRYEISSLVRYQCNQGYLQRHVPIIRCLPTGHWDEPRILCIDLSTYRR--HKRSPRSRSRAIATSEH >XP_030269061.1 aggrecan core protein-like isoform X2 [Sparus aurata] IRWIVLLSLCLHVISASFDYMDPEDVLSVSIPLEGPQRPLLGGSLVLPCYFEDHTVPDPGAPTITPLSHRIKWSLVTKEKVTTILVALEGQVRISESYLDRVHLVGYPVTPTDASIKISELRSTDSGVYRCEVQQGIEDNHDIVHVQVQGIVFHYRAIMGRYTLTFEKANAACTQNSAVMASPEQLQAAFDDGFHQCDAGWLSDQTVRYPIHDPRVNCYGDKEELPGVRTYGVRDLNETYDVYCFTEKMTGRVFYTAAAEKFTFSEAEASCANRGARLATTGQLYLAWQGGMDVCNAGWLGDRSVRYPINIRRPQCGGGLVGVRTVYLHTNQTGYPLPESRYDAFCYTESPDEE---SGFIEEGSGVLSVTTVTQSP-EVFFRRTTTESEAVGEVE-TQQPTVDFTYTLSPTELPLPQPPN-----------VTE----------------------LITDLIEPATARPDVGREPSKDMPPTGVVFHYRSDSGRYAFTFVEAQRACQSVGASIATPEQLQAAYKAGFHQCDAGWLLDQSVRYPIVFPRDKCTGDLGDQPGVRSYGLRPADERYDVYCYIDGLKGEVFHVRSAEGFTYDEAASSCQEQNAVLASTGELYAAWKMGFDKCRAGWLVDGSVRYPINKPRSECGGGKLGVHTVYANPNQTGFHERDAKFDAYCFRADL--------------------------------LLIANETGLNITE--------IQVLLNISSITDL---LRPAVPSIVPPIPVETSGSGSGSAD-FGSGS--------ASGDN---------------SGDSSGSLAA--------SGDGVISGDLSGS-------GDLS---------------SGDLSG-----------------SGDR----VVSG------------------------------------SGDLSGSGD---RVVSG-------------DLSGSG--DLSG--SG--DRVVSG----------------------------------DLSGSGDLSGRVVSG-DSSGSG-----------------------------DISGSGNQ--------------------IISGDLSGSKDLAGSAELPSGASGFSS------------------------------TDASGSTLSGEGSGITV---------VFSGID----------SIVSAEGSISGEPQEAGEGSTGILIF-----------PSTGEGSGELSGSGDLS-GSGS------------------------------------GSGFTSMGSGSGGSGQFSGMSSGFINGQ-------DFSG-------FSGFPSGSYSGSGQS--------GELSGSGD-AQILLIDGEMIDVSTNKEYELGGGLLEFS----GSGDISG---------------------------SGV------LSGDLSG--------------SGDISG-SGILSVDLSG-SGDISGS-----GILSV-DLSGSGDISGSGILSGDLSGSGPRSGTESGFTELTQEASGYLLYSSGQGSGGHLSGYGGLIY-HSGSGSGMSSVTFLTELSRDTTPSMELGQ--------------GSVEYSGEGSGSGG-----------------------------------------------------------------------------------------------------FFSGSGDNLFTASGPLVVLPSTSSEWALTETTAGPEEALSGTELSQTSGDIDETYGSAPAPAGLPTAATPASLQATGVFNPCEPNPCGDASCTVEDGVPV-C------------HDEQQCEDGWTKFQGNCYLHFSDREMWLDAEQRCRDLNAHLVSIITPEEQHFVNSNAQDYQWIGLNDKTVQNDFRWTDGTPLQYENWRPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKKGPVSCSAPPEVENAHMFGTRREEYPVNSIIRYQCNPGFTQRHPPVVRCRADGQWEKPQVECTDVK-ARRRTQRRSGGR---------H >XP_023807578.1 aggrecan core protein [Oryzias latipes] IRLTLLTSLSLSLVSAAFDYMDPEDVLSVDIPLEEPQRPLLGSSLVLPCFFQDHTVPDPGAPVIPPLSHRIKWSFVTKKNVSTVLVALGGQVRIGKGYLDRVQLLNYPQTPEDASIRISELRSSDTGVYSCEVQLGIEDDHDFVQVYVTGVVFHYRSFMGRYALTFEEAKTTCSQNSAAIASPEQLQAAYDDGFHQCDAGWISDQTVRYPIHDVRVNCFGDKEDLPGVRNYGVRDPREKYDVYCFAEKMTGRVFFTTSVEKFTVSEAALACSRHGAQLATTGQLYIAWQGGMDVCNTGWLADLSVRYPINVRRPQCGGGLLGVRTVYLHPNQTGFPLPESRHGAFCYADSPDDKLNSGSGSGDESGPWRVSTVTKDP-QLLFSWVTSESEVVGEME-TQASSLNVTNFENPK---MLVSPT------------------------------------VIITEAMEAINRPGVGKEPNTGMPPAGVVFHYRSHTGRYTFNFSEAQLACQSVGGSIASPQQLQAAYESGYHQCDAGWLLDQTVRYSIVVPRDKCAGDLGDQPGVRSYGMRPADERYDVYCYIEDLRGEVFHLESADGLTYDQAVLSCQEHGGILASTGELYAAWKTGFDKCRAGWLQDGSVRYPINIPRARCGGGKHGVHTVYAHPNQTGFPPREDRYDAYCIRSELL----VQKNTLYEQYQ---HHLINNNCCTSTILLTANETGPNATD--------NHKQLNHTSVADS---FRLSLSSIVPSVYVEMSGSGSGAEN-TAPEFAGGC----IFMNH---------------CGELSGSISGDYTSSTDPPGGVVTNSSGSGL--SGSRITDTS-SSLS---------ESDNMDG-----------------SGAG----SGSS-------NGTNHVDSLGSG---SMDGLESG-LSGSNSTDDTGSGLG--GSNST-------------DYTGSGL-SGSN--ST--DDTGSGL--------------------SDRTDDP-----LSGSTRTDDPGRGSNITDNSGSG-----------STRT---DDPGSGLSKITENSGSSHS-------------------GFSSIDGSGSGFIGPSGSGLSGLSSVDSSGLGLSGSNSTD-DKG---SGLSGSN---STDYTGSGLSGSNSTNDTGSGLSGSNIRLSGSDRGLSGSTRTDNITDNSGSGLSGSDRTDDPGSGLSGSSGLSGSNITESSHSGFSSIDGSGSGFIG-PSGV-DNSG--SGLSGLS---------SVDSSGL------SSTIIAIGSALSGYSNFDDSGSGLSGSS-------STDG-------LESGLSGSSSADGSG--------STLNGGGYNIPVVLSKLESFALELSREVKEGRPAILF--FPSGSGEPSG-SRNLSWSGPKTGLVESSGGSKAL---SGTTSGFSGFKGFTSGSLSGSGSQTREFEGSGN----PQIFLIHDKL-MDASVNQKQHELGGGPP-VLSGSGDFSGSGILGGSFSDSDPESVSVSGIPEVSKQASEILLHSSGQGGEIQLSGLRGSTF-VSQSVSGFSKNLFLREDPNRQRKSRER----------------GSEDHSGDGSQ--------------------------------------------------------------------------------------------------------SGNGDAIATAFFLG----HKQAEATTKPEKVTEVPVD------------------GSEHVPAGLLITAEPAFEET-EDLDVCHPNPCANGATCVESADSFRCLCLPSYGGERCDVDEQHCAEGWTKFQGNCYLHVSKRETWPGAEQHCRSLNAHLVSIITPEEQQFVNANAKAYQWIGLNDRTVENDFHWTDCTPVQYQNWKQNQPDNY-GSGENCVVMIWLKNGLWNDEPCHYHLPFTCKKGPVSCGEPPHVVNAVMFGRKRLEYPVRSIVRYQCNPGFRQRHSPVIRCQADGLWETPRVECVDAK-ARTRAGAGIIRRLPSATQGTAS >KAF7212766.1 aggrecan core protein-like [Nothobranchius furzeri] ---------------------------------KDTQKPSVVSEV------QDHTFPDPGAPPIVPLSHRIKWSHVTKEKVTTILVALEGQVHISKSFLDRVHLLSYPQTPTDASLKITELRSSDSGVYRCEVQHGIEDNHDIVHVHVQGIVFHYRAIMGRYTLTFEMAEAACSQNSAVVASSEQLQAAYDDGFHQCDAGWLSDHTVRYPIHDPRVNCYGDKEELPGVRTYGVRDLSETYDVYCFAEKMTGGVFYTTSAEKFTFSEAESACSRQGAQLATTGQLYLAWKSGMDICNAGWLRDGSVRYPINIRRPQCGGGLLGVRTVYLHTNQTGYPLSESRYDAFCYTEAPDEE----SGAAEGSGVLSVTSVTQSP-ELFFSRVTTESEVIGEVE-TQLPL-DLNETESQTEPSLLQPPS-------------------------------------VDDPIEAATAQPGVYKEPSETVSSEDVVFHYRSSAGRYAYMFVEAQLACQSVGGSIATPQHLQAAYEAGYHQCDAGWLLDQTVRYPVVFPREKCAGDLGDEPGVRSYGLRPADERYDVYCYTGKLTGEVFHVGSAEGFTYDEAVSSCQNHSAVLASTGELYAAWKMGFDKCRAGWLLDRSVRYPINNPRSECGGGKSGVHTVYAHPNQTRYPELDAKFDAYCFRANV--------------------------------LHQTNKTQLNITV--------IQALLNKTSVIDL---LMLNVSSIVLPIPVEMSGSGSGLAD-FGSGSVNGS----ISGDH---------------SGNLSGSLPG--------SGDGLTSGDSSGS-------GDIS---------------SRDMSG-----------------SGAL----SGSG---------------------------------QSSSGDSSGSGH---QSSSG-------------DSSGSG--HQSS--SG--DSSGSG----------------------------------HQSSSGDSSGQSSSG-DSSGSG------------SSS---XXXXXXXXXXGDSSGSGHQ--------------------SSSGDSSGSGHQSSSGSGSGHLAGSTS------------------------------TGGSGSGLSGVGSGITF---------FFSGAD----------NIVSEEGTSSGGPQEAGEGFTENCIV-----------SSSGSWSG--CSSGDLS-PSGS------------------------------------GSGATKSEDSLGGSGHFSGSTSGFTSGQ-------DLSG----------FLSGSSSGSGES--------GELSGSGD-LQIVLVDEKLVHASTLKENELGAGPLVFS----GSGDLLG---------------------------SSSGSG---LSGELSG--------------SGDLQ----ILQIDENL-IDESTAQKGYELGAGPH-VFSGSGDHSGLGVFSGDHSGSASRSESESGLMELTKEASGIVFYSSGQGSGGQISGFGSSSF-LSGSGSELSSVKLLTKAPRQTEAPQELGQ--------------GSVQYSGEESGS-------------------------------------------------------------------------------------------------------SFSGGRVFLSTAPGSEAVLPSPPAEPVPTEPTRLPEDHPNEAEETETFSETYMMPSFERIPEGLPTAAKPAFVET-GEVEVCHPNPCANGATCVESADSFKCLCLPSYGGKHCKIEEQQCEDGWTKFQGNCYLHISDRKDWLGAENHCQGLEAHLVSIITPEEQHFVNAFANDYKWIGLSDKAVERDFQWTDGTPMQYENWRPNQPDNYFNSGEDCVVMVWHEKGQWNDVPCNYHLPFTCKKGPVSCGAPPEVENAHTFGARRLQYPVNSIIRYQCKPGFRQRHLPVVRCQDDGHWEKPRVECTDVK-ARKRIQHRSSWD--PAVSSTEK >NP_001348429.1 aggrecan core protein isoform 1 precursor [Mus musculus] MTTLLLVFVTLRVIAAVISEPDHDNSLSVSIPQPSPLKVLLGSSLTIPCYFIDPMHPVTTAPSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEDDITIQTVTWPDLELPLPRNVTEGEALGSVILTAKPIFDLSPTISEPGEALTLAPEVGSTAFPEAEERTGEATRPWGFPAEVTRGPDSATAFASEDLVVRVTISPGAAEVPGQPRLPGGVVFHYRPGSTRYSLTFEEAQQACMHTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATRLEQFTFQEARAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIITPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVAPSPGEEGGSTPTSPSDIEDWIVTQVGPGVDAVPLEPKTTEVPYFTTEPRKQTEWEPAYTPVGTSPQPGIPPTWLPTLPAAEEHTESPSASEEPSASAVPSTS------EEPYTSSFAVPSMTELPGSGEASGALSGDFTGSGDASGRLDSSGQPSGGIESGLPSGDLDSSGLSPTVSSGLPVESGSASGDGE-VPWSHTPTVGRLPSGGESPEGSASGTGTETSTSGAEETSGLPSGGDGDVSGIPTGETSASGVEDLSGLPSGSETSTSGIEDISVLPTGESLETSASGVGDLSGLPSGSLETSASGAEDVTQLPTERGGLETSASGVEDITVLPRESLETSASGVEDVSGEDISVFDTSASG-------GEGLETSASGVEDLG--PSDSLETSASGV-DVTGFPSGRGDPETSVSGVGDFSGLPSGKEGLETSASGAEDLSGLPSGKEDLVGSASGALDFGKLPPGTLGSGQTPEVNGFPSGFSGEYSGADIGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVITATTSSELEGRGTIGISGSGEVSGLPLGELDSSADISGLPSGTELSGQASGSPDSSGETSGFFDVSGQPFGSSGVSEETSGIPEISGQTSGVTELNELSSGQPDVSGDGSGILFGSGQSSGITSVSGETSGISDLSGQPSGFPVFSGTATRTPDLASGTISGSGESSGITFVDTSFVEVTTTFREEEGLGSVELSGFPSGETELSGTSGTVDVSEQSSGAIDSSGLTSPTPEFSGLPSGVAEVSGEFSGVETGSSLPSGAFDGSGLVSGFPTVSLVDRTLVESITQAPTAQEAGEGPSGILEFSGAHSGTPDISGELSGSLDLSTLQSGQMETSTETPSSPYFSGDFSSTTDVSGESIAATTGSGESSGLPEVTLNTEGVTEPTVSQELGHGPSMTYTPRLFEASGDASASGDLGGAVTNFPGSGIEA-SVPEASSDLSAYPEAGVGVSAAPEASSKLSEFPDLHGITSAFHETDLEMTTSTEVNSNPWTFQEGTREGSAAPEVSGESSTTSDIDTGTSGMASGDRTESGEWSDVNVAISSTITESEWAQPTRYPTETLQEIESPNPSYSGEETQTAETTMSLTPTLSSSEGSGETADIDECLSSPCLNGATCVDALDTFTCLCLPSYRGNLCEIDQEQCEEGWTKFQGHCYRHFHDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGDPPVVEHARTLGQKKDRYEISSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPNTYKHRLQKRSMRPTRRSRPSMAH >XP_038956962.1 aggrecan core protein isoform X1 [Rattus norvegicus] MTTLLLVFVTLRVIAAVISEPDHDNSLSVSIPQPSPLKALLGTSLTIPCYFIDPMHPVTTAPSTAPLTPRIKWSRVSKEKEVVLLVATEGQVRVNSIYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVIVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDLELPLPRNITEGEARGNVILTAKPIFDMSPTVSEPGEALTLAPEVGTTVFPEAGERTEKTTRPWGFPEEATRGPDSATAFASEDLVVRVTISPGAVEVPGQPRLPGGVVFHYRPGSTRYSLTFEEAQQACIRTGAAIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSSETYDVYCYVDKLEGEVFFATQMEQFTFQEAQAFCAAQNATLASTGQLYAAWSQGLDKCYAGWLADGTLRYPIVNPRPACGGDKPGVRTVYLYPNQTGLPDPLSKHHAFCFRGVSVAPSP----GGTPTSPSDIEDWIVTRVEPGVDAVPLEPETTEVPYFTTEPEKQTEWEPAYTPVGTSPLPGIPPTWLPTVPAAEEHTESPSASQEPSASQVPSTS------EEPYTPSLAVPSGTELPSSGDTSGALSGDFTGSTDTSGRLDSSGEPSGGSESGLPSGDLDSSGLGPTVSSGLPVESGSASGDGE-IPWSSTPTVGRLPSGGESLEGSASGTGTETSASGTEEISGLPSGGDDGASVLPTGETSASGVEDLSGLPSGSETSTSGIEDISVLPTGESPETSASGVGDLSGLPSGSLETSASGVEDVTQLPTERGGLETSASGIEDITVLPRENLETSASGVEDVSGEDISVFETSASG-------GEGLETSASGVEDLG--LPDSLETSASGV-DVTGYPSGREDTETSVPGVGDLSGLPSGQEGLETSASGAEDLGGLPSGKEDLVGSASGALDFGKLPSGTLGSGQTPEASGLPSGFSGEYSGVDIGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVITATTASELEGRGTISVSGSGEESGPPLSELDSSADISGLPSGTELSGQTSGSLDVSGETSGFFDVSGQPFGSSGTGEGTSGIPEVSGQ---ISELSGLSSGQPDVSGEGSGILFGSGQSSGITSVSGETSGISDLSGQPSGFPVLSGTTPGTPDLASGAMSGSGDSSGITFVDTSLIEVTTTFREEEGLGSVELSGLPSGETDLSGTSGMVDVSGQSSGAIDSSGLISPTPEFSGLPSGVAEVSGEVSGVETGSSLSSGAFDGSGLVSGFPTVSLVDRTLVESITLAPTAQEAGEGPSSILEFSGAHSGTPDISGDLSGSLDQSTWQPGWTEASTEPPSSPYFSGDFSSTTDASGESITAPTGSGETSGLPEVTLITEGVTEPTVSQELGHGPSMTYTPRLFEASGEASASGDLGGPVTIFPGSGVEA-SVPEGSSDPSAYPEAGVGVSAAPEASSQLSEFPDLHGITSASRETDLEMTTGTEVSSNPWTFQEGTREGSAAPEVSGESSTTSDIDAGTSGMTSGDRTESGEWSDVNVTVSTTVPESRWAQSTQHPTETLQEIGSPNPSYSGEETQTAETAKSLTPTLASPEGSGETADIDECLSSPCLNGATCVDALDTFTCLCLPSYRGDLCEIDQEQCEEGWTKFQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNKNAQDYQWIGLNDRTIEGDFRWSDGHSLQFEKWRPNQPDNFFATGEDCVVMIWHERGEWNDVPCNYQLPFTCKKGTVACGEPPAVEHARTLGQKKDRYEISSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPNTYKHRLQKRSMRPTRRSRPSMAH >XP_024837356.1 aggrecan core protein isoform X1 [Bos taurus] MTTLLLVFVTLRVITAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNMRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPESFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGSVILTAKPDFEVSPTAPEPEEPFTFVPEVRATAFPEVENRTEEATRPWAFPRESTPGLGAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAIIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFWEAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPEEEEGSAPTAGPDVEEWMVTQVGPGVAAVPIGEETTAIPGFTVEPENKTEWELAYTPAGTLPLPGIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEVSGVISGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSGGEGPEV--SGVELEISASGVEDISGLPSGGEVDLSRIPSGEISASGVEDISGLPSGLEISASGVEDLSGIPSGEGPEVSASGVEDLIGLPSGGPEVSASGVEDLSGLPSGGEGPEVSASGVEDLSRLPGEGPEVSASGVEDLSVEDLSVLEVSASGDISRLPSGEGPEVSASGVEDLSVLPSGHLEISASGVEDLSRLPSGGEDLETSASGVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLESGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQISGVTELSGLASGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAVSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEVGVSGTSGLADVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASGAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGLVEPSGEPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGVEVSSVPESSGETSAYPEAEVGASAAPEASGGASGSPNLSETTSTFHEADLEGTSGLGVSGSPSAFPEGPTEGLATPEVSGESTTAFDVSVEASGLASGDRTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPASAGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDVCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSHPSTAH >XP_015147464.2 aggrecan core protein isoform X1 [Gallus gallus] MTTLLLVFVCLQAITTAASASDSSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDT----NALLTPRIKWSKLSNGTEIVLLVATGGKIRLNAEYREVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGVVFHYRAISTRYTLNFERAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHLPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTGELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPNQTGYPHPSSRYDAICYSGDDFEAVPGLFTDEVGTEAFTIQTVTQTEVELPLPRNVTEEEARGSIA-TLEPM-EITATATELYEAFTVLPDTVETASPREENVTREITGIWAVPEEATPGLESASPFTIEDHLVQVTAAPDVALLPRQPISPTGVVFHYRAATSRYAFSFIQAQQACLENNAVIATPEQLQAAYEAGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPEQFTFQEAQLYCESQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVSPRPACGGDAPGVRTIYQHHNQTGFPDPLSRHHAFCFRAL---PSVVE-EGVTSLFE---EEVMVTQLIPGVEGIPSGEETTVETELSSEPENQTAQGTEVFPTDVSLLSARPSAFPPATVIPEETSTNASIPEV---SGEFPESGEHPTSGEPS-----------------ASGATSGEPT-----SVGFELSGEQSGIGESGLPSVDLQSSGF-------VPGESGLPSG------------------------------------------------------------------VDISGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------PSAEEEVTVSVSRIPEVSGMPSG---------------------------AESSGLHSGFSGEISGTELISGLPSG--EESGLASGFPTISLVDSTLVEVVTAAPGRQEEGKGSIGVSGEEELSGFPSAEWDSS-GARGLPSGAETSGEQSGVPELSGEHSGVPGLSGEPFEVPELSGEHSGVTELSGEHSGLPELSGEPFGVPELSGFPSGL-----------DISGEPSGAPEV----SGPVDVSGLTSGV--------DGSGEVSGVTFISTSLQEVTPSVAEAEAKEILEISGLPSG--ETSGMSGSLDVSGQPSGHIDFGGSASGVLEMSGFPSGAVESSGEASGVEVTSGLASG--EESGLTSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGFLSGDRGVSGDGSGAVQSSGLPSGTGDFSGEPSGIPYFSGDISGATDLSGQPSAVTDISGEDSGLPEVTLVTEVVTRPTVSQELGGETAVT-FPYVFGPSGEGSASGDLSGGASA--EGGIETSTAYEISGESSAFPETSIETSTDQEISGEASAYPEISVETSTHLETSGETSAIQEVSGETSAFPEIRGETSAFPEIGIETSTAHEGSGETPGTTS----HITGVSGPDAVISTSAPDVELAQEPRNTEETQLEIEPSTPAASGQETETAAVLDNPHLHPASQEAVDALEDTDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLCEIDLANCEEGWIKFQGHCYRHFEERETWMDAESRCREHQAHLSSIITPEEQEFVNSHAQDYQWIGLSDRAVENDFRWSDGHSLQFENWRPNQPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSLVRYQCDHGYIQRHVPTIRCQPNGHWEEPRISCTNPSSYQRRLYKRSPRSRLRPG--VVH >XP_020953956.1 aggrecan core protein isoform X1 [Sus scrofa] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPQPSPLRVLLGGSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGQVRVNSAYQDRVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGTVILTVKPVFEFSPTAPEPEEPFTFAPGTGATAFPEAENRTGEATRPWAFPEESTPGLGAPTAFTSEDLVVQVTMAPGATEFPGQPRLPGGVVFHYRPGSSRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSTPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLASTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPGEEEGGTPTSLPDLEERIATQVGPGVAAVPVGEETTEVAAFTTEPENRTEWEFVYTPVGTSPLPGIPPTWPPTSAATEEGTEGPSATEAPSTSEEPFPSEEPFPSEQPSTLSAPVPSRTELPGSGEVSGAVSGDFTGSGEVSGHLDYSGQPSGEIASGLPSEDLDSSGLTSAVGSGLPVESGLASGDEDKITWSSTSKVDRLPSGGEGPEGSVSGVEPEISASGVEDLSRLPSGEGPDISQLPSGEISASGIEDLSRLPSGPEISASGVEDLSRLPSGEGPEISASGVEDISQLPSGGPEISASGVEDLSRLPSGGEGPEISASGVEDISQLPGEGPEISASGVEDLSREDLSRLEISASGDISQLPSGEGPEISASGVEDLSRLPSGHLETSASGVEDLSGIPSGGEDLESSASGVGDLSGLPSGREGLEIYASGAEDLSGLTSGKEDLAGSASGDLDVGRMPSGTLESGQAPEVSGLPSGFSGEYSGVDLGSGPSSGLPDFSELPSGFPTVSLVDTTLVEMVTATTASELEGRGTIGVSGAGETFGLPFSELDISGGASGHPSGAELSGQASGSPDISGETSGLFDVSGQPSGFPDISGGTSGLFEVSGQTSGVTELSGLSSGQPDISGDASGVLSGVGQPFGLTDVSGETSGVPDLSGQPSGWPGFSGMPSGTPDLVSSATSGSGESSGITFVDTSLVEVTTTRKEEEGLGSVELSGLPSGEADLSGASGVVDVSGLASGATDSSGFTSQPPEFSGLPSGVTEVSGESSGVEIGSSLPSGAYDGSGLPLSAPTVYLVDRTLVESVTQAPTAQEAGEGPPGTLELSGAHSGVPDMSGDHSGSVDLSGLQSGLAEPSGEPASTPYFSGDFSVTTDISGDSSAATSTSGEASGLPEVTLIAEGVTEPTVSQELGQRPPVTHTPQLFESSGEASASGDV----PRFPGSGVEAPPIPESSRESSAYPEAETGASAAPEASGGASGSPDLTEATSAFHEADLEGTSGLGVSVSTSAFQEGTREVSAAPEVSRESTTTYDVGPEASGVSSGDRTESGDLSGLEVAISTAIPEYAWTQQTQRPAEAPLEIESSSPVHSGEEMPTAKPATSQTSIPTPPGQTDESADFDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDLCEIDQKLCENGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRSLRRSRPSTGP >NP_001106926.3 aggrecan core protein precursor [Canis lupus familiaris] MTTLLLVFVTLRVITAASSLSDPDNSLSVSIPEPSPMRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRITKEKEVVLLVATEGQVRINSAYQDKVSLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTVKPIFDLSPTAPEPEEPFTFVPEVGVTAFPEAENRTGEATRPWGVPEESTPGP-AFTAFTSEDHVVQVTAVPGAAEVPGQPRLPGGVVFHYRPGSARYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDKLEGEVFFITRLEQFTFQEALAFCESHNATLASTGQLYAAWSQGLDKCYAGWLSDGSLRYPIVTPRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSAVPSPGEEEGGTPTPS-VVEDWIATQVGPGVAAVPMGEETTAILDFTIEPENQTEWEPAYSPAGTSPLPGIPPTWPPTSTATEESTEGPSGTEVPSVSEEPSPSEEPFPWEELSTLSPPGPSGTELPGSGEASGVVSGDFTGSGEVSGHPDSSGQLSGESASGLPSEDLDSSGLTSAVG------SGLASGDEDRITLSSIPKV-----EGEGLETSASGVELEVSASGVEDLSGLPSGEGPDLSRLPSGEVSASGVGDLSGLPSGLETSTSGVEDLSGLPSGEGPEASTSGVGDLSRLPSGGPEASASGVGDLSRLPSGGESPEASASGVGDLSGLPGEGPEASASGVGELSGGDLSGLEASASGDLSGLPSGEGPEASASGIGDISGLPSDHPETSASGVEDLSGLPSGVEGPETSASGVEDLSELSSGGEGLETSASGAEDLSGLPSGKEDLIGSASGALDFGRIPSGTLGSGQAPEASSLPSGFSGEYSGVDFGSGPSSGLPDFSGLPSGFPTISLVDTTLVEVITTTSASELEGRGTIGISGAGETSGLPVSELDISGAVSGLPSGAELSGQASGSPDMSGETSGFFGVSGQPSGFPDISGGTSGLFEVSGQTSGVTELSGLYSGQPDVSGEASGVPSGSGEPFGMTDLSGETSGVPDISGQPSGLPEFSGTTSGIPDLVSSTMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEVDLSGASGTMDISGQSSGATDSSGLTSQLPEFSGLPSGAAEVSGESSGAEIGSSLPSGTYEGSGLPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDVSGDHSGSLDLSGMQSGLVEPSGEPSSTPYFSGDFSGTMDVTGEPSTAMSASGEASGLLEVTLITEGVTEPTVSQELAQRPPVTHTPQLFESSGEASASGEISGATPAFPGSGLEASSVPESSSETSDFPERAVGVSAAPEASGGASGAPDVSEATSTFPEADVEGASGLGVSGGTSAFPEGPREGSATPEVQEEPTTSYDVGREALGTASGDRIESGDLSGLDVVISTSVPESEWIQQTQRPAEAHLEIEASSPLHSGEETQTAETATSPTSIPTSPSGTDESPDIDECLSSPCLNGATCVDAIDSFTCLCLPSYRGDLCEIDQELCEEGWTKFQGHCYRYFPDRESWVDAESRCRAQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHSLQFENWRPNQPDNFFVSGEDCVVMIWHEKGEWNDVPCNYYLPFTCKKGTVACGDPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEKPRITCTDPSTYKRRLQKRSSRAPRRSRPSTAH >XP_027812861.1 aggrecan core protein isoform X1 [Ovis aries] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEPEEPFTFAPEVRATAFPEVENRTGEATWPWAFPRESTPGVGAPTAFTSEDLVVQVTLAPGATEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKEACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGLRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVVPSPGEEEGSTPTAGPEVEDWIVTEVGPGVAAVPVGEETTAVPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPTSGEASGVVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDLDSSGLTPTVGSGLPVESGLPSGEEERITWTSPPIVDRLPSGGEGPEVSASGVELEISASGVEDLSRLPSGEGPDLSGIPSGEVSASGVEDLGVLPSGLEISASGVEDLSRLPSGEGPEVSASGVEDLGVLPSGGPEVSASGVEDLSRLPSGGEGPEVSASGVEDLSGLPGEGPEVSASGVEDLSREDLSRLEVSASGDLSRLPSGEGPEVSASGVEDLGVLPSGHLEISASGVEDLSRLPSGGEDLETSASGVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGLPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPEISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGVPDLVSSAVSGSGESSGIMFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEAGLSGTSGLVDVSGLSSGAIDSSGFTPQPPEFSGLPSGVTEVSGEASGAASGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGTPSGAPDMSGDHLGSLDQSGLQSGLVEPRGEPASTPYFSGDFSGATDVSGESSAATSTSGEPSGLPEVTLITEGVTEPTVSQELGQRPPVTYTPKLFESSGEASVSGDV----PSFPGSGVEASPVPESSGETSAYPEAEVGASAAPEASGGASGSPNLSETTSTFHEADLEGTSGLGASGRPSAFPEGPTEGLATPEVSGESTTAFDVSVEASGLASGDRTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSTGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSRPSTAH >XP_003952775.3 LOW QUALITY PROTEIN: aggrecan core protein [Pan troglodytes] MTTLLWVFVTLRVITAAVTVSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFPEVENETGEATRPWGFP---TPGLGPATAFTSEDLVVQVTA------VPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLHTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIATQVVPGVAAVPVEEETTAVPSFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEEPSASEEPYTPSPPVPSWTELPSSGEESGAVSGDFIGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLTSTVGSVLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGLETTAPGVEDISGLPSGEVLDISGLPSGETTAPGVEDISGLPSGLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGVLETTAPGVEDISGLPSGGEVLETTAPGVEDISGLPGEVLETTASGVEDISGEEISGLETSTSADVSELPSGEGLETSASGVEDLSRLPSEVLEISASGFGDLSGLPSGGEGLETSASEVGDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGET----------SGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVATTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVNSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDFASTTNVSRESSVAMGTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTHTPQLFESSGDVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTFQEG--EASAAPEVSGESTTTNDVGTEAPGTASGDRTESGDPSGLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLYSGEETHTVKTATSPTSIPASPEWKRESAPARSCAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_008249943.1 PREDICTED: aggrecan core protein isoform X1 [Oryctolagus cuniculus] MTTLLLVLVALRVIAAAISGSDLDNALSVSIPQPSPVRALLGTSLTIPCYFIDPVHPVTTAPSTAPLTPRIKWSRISKDKEVVLLVANEGRVRINSAYQDKVSLPNYPAIPSDATLEIQSLRSNDSGIYRCEVMHGLEDSEATLEVVVKGVVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAASECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFMDIPENFFGVGGEEDITVQTVTWPDVELPVPRNITEGEARGSVVLTAKPVLDVSPTAPQPEE--TFAPGVGATAFPGVENGTEEATRPRGFADEATLGPSSATAFTSADLVVQVTAAPGVAEVPGQPRLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAAMASAEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFQEALEFCESHNATLASTGQLYAAWSRGLDRCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGTSEAPSPGPEEGGTATPASGLEDWIVTQVGPGVAATPRAEERTAVPSFATEPGNQTGWEAASSPVGTSLLPGIPPTWPPTGTAAEGTTEGLSTAAMPSASEGP------------YTPSSLVARETELPGLGVTSVPISGDLTSSGEASGLFGPTGQPLGGSASGLPSGELDSGSLTPTVGSGLPIGSGLASGDEDRIQWSSSTEVGGVTSGAEIPETSASGVGPETFASGVTDLSGLPSGAEIDLSGLPSGETSASGVTDLSGLPSGLETSASGVTDLSGLPSAEILETSASGVGDLSGLPSGIPETFASGVTDLSGLPSGAEILETSASGVTDLSGLPAEIPETSASGVTDLSGTDLSGLETSASG-------AEILETSASGVTDLSGLPSEILETSASGVGDLSGLPSGGEIPETFASGVGDLSGLPPGREDLETLTSGVGDLSGLSSGKDGLVGSASGALDFG----GTLGSGQIPETSGLPSGYSGEYSEVDLGSGPSSGLPDFSGLPSGFPTVSLVDTPLVEVVTATTARELEGRGTIGISGAGEISGLPSSELDVSGGT----SGADISGEA----DVGGEASGLI-VRGQPSGFPDTSGEA----------FGVTEVSGLSSGQPDLSGEASGVLFGSGPPFGITDLSGEP------SGQPSGLPEFSGTTHRIPDLVSGATSGSGESSGIAFVDTSVVEVTTTLREEEGLGSVEFSGFPSGETGLSGTPETIDVSGQSSGTIDSSGFTSLAPEVSGSPSGVAEVSGEASGTEITSGLPSGVFDSSGLPSGFPTVSLVDRTLVESVTQAPTAQEA-EGPSDILELSGVHSGLPDVSGAHSGFLDPSGLQSGLVEPSGEPPRTPYFSGDFPSTPDVSGEASAATSSSGDISGLPEVTLVTEGVTRPTVSQELGQGPPMTHVPKLFESSGEALASGDTSGAAPAFPGSGLEASSVPESHGETSAYAEPGTKAAAAPDASGEASGSPDSGEITSVFREAAGEGASGLEVSSSSLASQQGPREGSASPEVSGESTTSYEIGTETSGAASEDRAESGDLSGVPVDVVTNVPEAEWIQHSQRPAEMWPETKSSSPSYSGED--TAGTAASPADTPGEPGPTTAAIDIDECLSSPCVNGATCVDASDSFTCLCLPSYGGDLCETDQEVCEEGWTKFQGHCYRHFPDRETWVDAEGRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVEHARTFGQKKDRYEINSLVRYQCAEGFTQRHVPTIRCQPSGHWEEPRITCTHPTTYKRRVQKRSSRTLQRSQASSAP >XP_024088629.1 LOW QUALITY PROTEIN: aggrecan core protein [Pongo abelii] MTTLLWVFVTLRVITAAVTVSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQEKVSLPNYPAIPSDATLEIQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDKAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFPEVENETGEATRPWGFP---TPGLGPATAFTSEDLVVQVTA------VPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIATQVVPGVAAVPVEEETTAVPLFTTEPENQTEREPVYIPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEKPSPSEEPSASEEPYTPSPPVPSWTELLSSGEESGAVSGDFTGSGDVSGHLDFSGQLSGERASGLPSGDLDSSGLTSTVASGLPVESGLASGDEERIEWSSTPTVGELPSGAEILEGSISGVGLETTAPGVEDISGLPSGEVLDISGLPSGETTXPGVEDISGLPSGLETTXPGVEDISGLPSGEVLETTXPGVEDISGLPSGVLETTAPGVEDISGLPSGGEVLETTAPGVEDISGLPGEVLETTAPGVEDISGEDISGLETSTSADVSELPSGEGLETSASGVGDLSRLPSEVLEISASGVGDLSGLPSGVEGLETSASEVGDLSGLPSGREGLETSASGTEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGGASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGET----------SGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITDLSGETSGVSDLSGQPSGLPGFSGATSRVPDLVSGATSGSGESSGITFVDTSLVEVTATFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGEASGAEIGSSLASGAYYGSGLPSGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILEISGAHSGAPDMSGDHSGFLDLSGLQSGLVEPSGEPPGTPYFSRDFASTTDVSGESSAAMGTSREASGLPEVTLITEGVTEPTVSQELGQRPPVTHTPQLFESSGEVSAAGDISGATPVLPGSGVEVSSVPESSNETSTHPEAGVGASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTFQEG--KASAAPEVSGESTTTNDVGTKAPGTASADRTESGDLSGLGIVISTSIPESEWTQQTQRPVEAHLEIESSSLLYSGEETHTVQTATSPTSIPTSPEWKRESAPARSCAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_019475050.1 aggrecan core protein [Meleagris gallopavo] MTTLLLVFVCLQAITTAASASESSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDT----SALLTPRIKWSKLSNETEIVLLVATGGKIRLNAEYKEVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHLPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEQMQGKVFYATSPEKFTFQEAFDKCHSLGARLATTGELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLNPNQTGYPHPSSRYDAICYSGDDFEAIPGQFTDEVGTEAFTIQTVTQTEVELPLPRNATEEEARGSIA-TLEPM-EITATATELYEAFTVLPDTVETASPGEENVTREVTGIWAVPEEATPELESASPFTVEDHLVQVTAAPDVALLPRQPISPTGVVFHYRAATSRYALSFVQAQWACLENNAVIATPEQLQAAYEAGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKESSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPERFTFQEAQLYCASQNATLASAGQLHAAWKQGLDRCYPGWLADGSLRYPIVSPRPGCGGDAPGVRTIYQHYNQTGFPDPLSRHHAFCFRAL---PSVEE-EGVTSHFE---EEVMVTQVIPGVEGIPSGEETTVETELSAEPENQTAWGTEVIPTDVSLLSARPSAFPPATVIPEETSTSASIPEV---SGEFPESGEHPASGEPS-----------------ASGATSGEPT-----SGGFELSGEHSGIGESGLPSVDLQSSGF-------VPGESGLPSG------------------------------------------------------------------VDTSGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------PSAEEEISVSISRIPEVSGMPSG---------------------------AESSGLHSGFSGEISGTELISGLPSG--EESGLTSGFPTVSLVDSTLVEVVTAAPGRQEEGKGSIGVSGEGELSGFPSAEWDSS-GARGLPSGAEASGEHSGVPELSGEHSGVPGLSGEPFEVPELSGEHSGVPELSGEHSGLPELSGEPLGVPELSGFPSGL-----------DISGEPSGIPEV----SGLVDVSGLTSGV--------DGSGEISGITFISTSLQEVTPSTAEAEAKEILEISGLPSG--ETSGMSGSLEVSGQPSGHIDFGGSASGVLEMSGFPSGAVESSGETSGVEVTSGLASG--EESGLPSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGFLSGDRGLSGEGSGAVQSSGLPSGTGDFSGEPSGIPYFSGDISGATDLSGQPSAVTDISGEDSGLPEVTLVTEVVTRPTVSQELGGETAVT-FPYIFGPNGEGSASGDLSGGTSA--EGGIETSTAYEISGETSAFPETSIETSTGQEISGEASAYPEISVETSTNLETSGETSAIQEVSGETSAFPEIRGETSAFPEIGIETSTAHESSGETPGATS----HIAGVSGPDVVISTSAPDVELTQEPRNTEETRLEIEPSTPAASGQETETAAVLDSPHLHPASQEAIDALEDTDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLCEIDLANCEEGWIKFQGHCYRHFEERETWMDAESRCREHQAHLSSIITPEEQEFVNSHAQDYQWIGLSDRAVENDFRWSDGHSLQFENWRPNQPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSLVRYQCDHGYIQRHVPTIRCQPNGHWEEPRISCINPSSYQRRLYKRSPWSRSRPG--VMH >XP_034795266.1 aggrecan core protein isoform X1 [Pan paniscus] MTTLLWVFVTLRVITAAVTVSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPSDATLEVQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFPEVENETGEATRPWGFP---TPGLGPATAFTSEDLVVQVTA------VPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLRDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDECYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISAVPSPGEEEGGTPTSPSGVEEWIATQVVPGVAAVPVEEETTAVPSFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEEPSALEEPYTPSPPVPSWTELPSSGEESGAVSGDFTGSGDVSGHLDFSGQLSGDRASGLPSGDLDSSGLISTVGSGLPVESGLPSGDEERIEWPSTPTVGELPSGAEILEGSASGVGLETTAPGVEDISGLPSGEVLDISGLPSGETTAPGVEDISGLPSGLETTAPGVEDISGLPSGEVLETTAPGVEDISGLPSGVLETTAPGVEEISGLPSGGEVLETTAPGVEEISGLPGEVLETTASGVEDISGEEISGLETSTSADVSELPSGEGLETSASGVEDLSRLPSEVLEISASGFGDLSGLPSGGEGLETSASEVGDLSGLPSGREGLETSASGAEDLSVLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSGLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGET----------SGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITDLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGTTSGSGESSGITFVDTSLVEVATTFKEEEGLGSVELSGLPSGEADLSGKSGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAEIGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTHTPQLFESSGEVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHEADLERSSGLGVSGSTLTFQEG--EASAAPEVSGESTTTNDVGTEAPGTASGDRTESGDLSGLGVVISTSIPESQWTQQTQRPAETHLEIESSSLLYSGEETHTVETATSPTSIPASPEWKRESAPARSCAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_023110702.1 LOW QUALITY PROTEIN: aggrecan core protein [Felis catus] MTTLLLVFVTLRVITAASAISDPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLSPRIKWSRISKEKEVVLLVATEGQVRVNSAYQDKVSLPNYPAIPSDATLEIQNLCSNDSGMYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEDMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQSGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNVTEGEARGNVILTVKPIFDVSPTIPEPEEPFTFVPEVGATAFPEAENRTGEATRPWGVPEESTPGL-AFTAFTSEDHVVQVTAVPGATEVPGRPRLPGGVVFHYRPGSARYALTFAEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFVTRPEQFTFEEALAFCESHNATLASTGQLYAAWSGGLDKCYAGWLSDGSLRYPIVTPRPSCGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGVSAAPSPGEEEGGTATPS--VEDWIATQVVPGVAAVPSGEETTTSPDFTTEPENQTEWELAYTPVGTSPPPGIPPTWPPTSAATEESTEGPSGTEVPSASEEPSPSEEPFPWEEPSTLAPPVPSGTELPGSGEASGVVSGDFTGSGEVSGRLDSSGQPSGEISSGLPSGDLDSSGLTSAVGSGLPVESGLASGDEDRITGPSIPKV-----GGEGLETSASGVGPEVSASGVGDLSGLPSAEGPVLSGLPSGEVSASGVEVLSGLPSAPEVSASGVEVLSGLPSGEGPEVSASGVGDLSGLPSAGPEVSASGVGDLSGLPSAGEGPEVSASGVEVLSGLPAEGPEVSASGVEVLSGGDLSGLEVSASGVLSGLPSGEGPEVSASGIGDLSGLPSEGLETSASGVGGLSGLPSGIEGPETSASGVGDLSEFYSGGEGLETSASGAEELSGLPSGKEDLIGSASGDLDLGRIPSGTPGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTISLVDTTLVEVVTATTASELEGRGTIGISGAGETSGLPLSELDISGAVSGLPSGAELSGQASGSPDTSGETSGFFGVSGQPSGFPDISGGTSGLFEVSGQTSAVTELSGLVSGQPDVSGEASGVLSGSGQPFGITDLSGETSGV----------PGVSGATSGIPDLVPSAVSGSGASSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEAGLSGTSGIMDVSGQSSGAVDSGGFTSPPPEFSGLPSAVAEVSGESSGAEIGSSLPSGAYDGSGLASGFPTVSLVDRTLVESVTQAPTAQEAGEGPSGIVELSGAHSGAPDVSGDHSGFLDLSGPRSGLVEPSGEPSSTPYFSGDFSGTVDVSGESSAATGTGGEASGLPEVTLITEGVTEPTVSQELAQRPPVTHTPRLFESSGEASASGEISGATPTFPGSGV--GSVPESSSETPAFPEAGVGASAAPEASGGASGSPDVSEATSTFPDADVEGGSGLAVSGSTSAFPEGPGEGLATPEAREEPTTTHDVGTEASGMASGDRTEGGDLSGLDVVISTSVPESEWTQQTQRPAEAHLEIESSSPLHSGEETQTAETATFPTSIPTPPGGTDESADIDECLSSPCLNGATCVDAIDSFTCLCLPSYRGDLCEIDQELCEEGWTKFQGHCYRYFPDRESWVDAESRCRAQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHSLQFENWRPNQPDNFFVSGEDCVVMIWHEKGEWNDVPCNYYLPFTCKKGTVACGDPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHVPTIRCQPSGHWEEPRITCTDPSTYKRRLQKRSSRPARRSRPSTAH >XP_018865821.2 LOW QUALITY PROTEIN: aggrecan core protein [Gorilla gorilla gorilla] MTTLLWVFVTLRVITAAVTVSDHDNSLSVSIPQPSPLRVLLGTSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRVSKEKEVVLLVATEGRVRVNSAYQDKVSLPNYPAIPTDATLEIQSLRSNDSGVYRCEVMHGIEDSEATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQAGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYVHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITVQTVTWPDMELPLPRNITEGEARGSVILTVKPIFEVSPSPLEPEEPFTFAPEIGATAFPEVENETGEATRPWGFP---TPGLGPATAFTSEDLVVQVTA------VPGQPHLPGGVVFHYRPGPTRYSLTFEEAQQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKNSSPGVRTYGVRPSTETYDVYCFVDRLEGEVFFATRLEQFTFQEALEFCESHNATLATTGQLYAAWSRGLDKCYAGWLADGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLPDPLSRHHAFCFRGISVVPSPGEEEGGTPTSPSGVEEWIATQVVPGVAAVPAEEETTAVPSFTTEPENQTEWEPAYTPVGTSPLPGILPTWPPTGAATEESTEGPSATEVPSASEEPSPSEEPSASEEPYTPLPPVPSWTELPSSGEESGAVSGDFIGSGDVSGHLDFSGQLSGDRASELPSGDLDSSGLTSTVGSGLPVESGLASGDEERIEWSSTPTVGELPSGAEILEGSASGVGLETTAPGVEDISGLPSGEVLEISGLPSGETTAPGVEEISGLPSGLETTAPGVEEISGLPSGEVLETTXPGVEEISGLPSGVLETTAPGVEEISGLPSGGEVLETTAPGVEDISGLPGEVLETTAPGVEDISGEEISGLETSTSADVSELPSGEGLETSASGVEDLSRLPSEVLEISASGVGDLSGLPSGGEGLETSASEVGDLSGLPSGREGLETSASGAEDLSGLPSGKEDLVGSASGDLDLGKLPSGTLGSGQAPETSDLPSGFSGEYSGVDLGSGPPSGLPDFSGLPSGFPTVSLVDSTLVEVVTASTASELEGRGTIGISGAGEISGLPSSELDISGRASGLPSGTELSGQASGSPDVSGEIPGLFGVSGQPSGFPDTSGET----------SGVTELSGLSSGQPGVSGEASGVLYGTSQPFGITGLSGETSGVPDLSGQPSGLPGFSGATSGVPDLVSGATSGSGESSGITFVDTSLVEVATTFKEEEGLGSVELSGLPSGEADLSGKPGMVDVSGQFSGTVDSSGFTSQTPEFSGLPSGIAEVSGESSRAETGSSLPSGAYYGSGTPSSFPTVSLVDRTLVESVTQAPTAQEAGEGPSGILELSGAHSGAPDMSGEHSGFLDLSGLQSGLVEPSGEPPGTPYFSGDFASTTNVSGESSVAMGTSGEASGLPEVTLITEGVTEPTISQELGQRPPVTHTPQLFESSGEVSTAGDVSGATPVLPGSGVEVSSVPESSSETSAYPEAGFGASAAPEASREDSGSPDLSETTSAFHKADLERSSGLGVSGSTLTFQEG--EASAAPEVSGESTTTNDMGTEAPGTASGDRTESGDLSGLGVVISTSIPESEWTQQTQRPAETHLEIESSSLLNSGEETHKVETATSPTSIPASPEWKRESAPARSCAEEPCGAG-TCKETEGHVICLCPPGYTGEHCNIDQEVCEEGWNKYQGHCYRHFPDRETWVDAERRCREQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDRTIEGDFRWSDGHPMQFENWRPNQPDNFFAAGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGEPPVVEHARTFGQKKDRYEINSLVRYQCTEGFVQRHMPTIRCQPSGHWEEPRITCTDPTTYKRRLQKRSSRHPRRSRPSTAH >XP_021145604.1 aggrecan core protein isoform X1 [Columba livia] MTTLLLVFVCLRIIAAAVAVSDSSDGLEVKIPEQSPLRVVLGSSLNIPCYFNIPEEEDT----SALLTPRIKWSKLSNGTEVVLLVATGGKIRLNSEYREVISLPNYPAIPTDATLEIKALRSNHTGIYRCEVMYGIEDRQDTIEVLVKGIVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGYEQCDAGWLADQTVRYPIHWPRVQCYGDKDEFPGVRTYGVREPDETYDVYCYAEQMQGKVFYASAPEKFTFQEAFDKCHSLGARLATTGELYLAWKDGMDMCSAGWLADRSVRYPISRARPNCGGNLVGVRTVYLHANQTGYPHPDSRYDAICYSGDDVETVPGQFIDERGSEAFTIQTVTQTEVELPLPRNATEEEARGSIA-TLEPI-EITPPATELYEGFTVLPDTAETAAPEEENVTRGVTEVWAVPEEATPGLESASVFTVEDQLVRVTAAPGVGLLPEQPISPTGVVFHYRSATSRYAFSFVQAQQACLENNAVIATPEQLQAAYEAGFDQCDAGWLRDQTVRYPIVNPRSNCVGDKENSPGVRSYGMRPASETYDVYCYIDRLKGEVFFATQPEQFTFPEAQQYCESQNATLASVGQLHAAWKQGLDRCYAGWLADGSLRYPIVSPRPACGGDAPGVRTIYQHYNQTGFPDPLSRHHAFCFRAL---PPVEE-DGVTLFFE---EDALATQVIPGVEGVPSGEEVTVETEFATQPENQTAWGTEVLPTDVSLLPVSPSVFPPATIIPEETSTNASISEV---SGEMTESGEHQVSGETSA-------------SGWVPEVASGEPT-----SGLFELSGEHSGIGESGLPSVDLHTSGF-------LPGESGLPSG------------------------------------------------------------------VDISGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------TSGEEDVSVSTSRTPEVSGLPPG---------------------------VESSGLPSGFSGEISGTELVSGVSSG--EESGLASGFPTISLVDTTLEEVVTTVPERQEEGKGSIGVSGEGDLSGFPSAEWDTSEGTHGLPSGAELSGEPSREP----------------------------------------ELSGEPSGVPELSGLPSGL-----------DVSGEPSGTHEV----SGLVDLSGLTSGI--------DGSGEALGVTFVDTSLEEVTPSITRAEAKEILEISGLPSGGGDTSGMSGSSDISGEPSGHVDFGGSASGVLEMSGHPSGVIDSSGEVSGVDVTSGLLSG--EESGLTSGFPTVSLVDTTLVEVVTQTSVAQEVGEGPSGMIEISGFPSGDRGLSGEASGAILTSGFPSGTGDFSGEPSGIPYISGDTSGTTDLSGQSSAVTDASGEASGLPEVTLVTQVVTIPTVSQELGGETAVT-FPYGFGPSGGASASGELSGETSAWPESGMETSTAYEISGEASAFPETSIETSTIQEISGETSAFPETSVETSTIHEISGETSAIQEISGETSAFPEISGETSAFPEIRIETSTSQEARGETPATTSGAVTHITGVSGPDFVISTSTPDVEPTQGHRNPEEAQLEIEPSPPAVSEQQTETDAVLDNPHLPQVSQEAIDALEDTDECHSSPCLNGATCADGIDSFKCLCLPSYGGDLCEIDLQNCEEGWTKFQGHCYRHFEDRETWMDAENRCRQYQAHLSSIITPEEQDFVNSHAQDYQWIGLSDRAVENDFRWSDGHSLQFENWRPNQPDNFFSAGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSLVRYQCNQGYIQRHVPTIRCQPNGQWEDPRISCINPSNYQRRLYKRSPRSRSRLSGRAVH >XP_017922102.1 PREDICTED: aggrecan core protein [Capra hircus] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPDFEVSPTAPEREEPFTFAPEVRATAFPAVENRTGEATWPWAFPRESTPGVGAPTAFTSEDLVVQVTLAPGVTEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKEACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGLRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSAAPSPGEEEGSTPTAGPEVEDWIVTEVRPGVAAVPVGEETTAIPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGEATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPTSGEASGVVSGDFTGSGEISGHLDFSGQPSGESASGLPSEDFDSSGLTPTVGSGLPVESGLPSGEEERITWTSAPKVDRLPSRGEGPEVSASGVELEISASGVEDLSGLPSGEEGDLSGIPSGEVSVSGVEDLSRLPSGPEVSASGVEDLSRLPSGEGPEVSASGVEDLGVLPSGGPEVSASGVEDLGVLPSGGEGPEVSASGVEDLGVLPGEGPEVSASGVEDLGVEDLSVLEISASGDLSRLPSGEGHEISASGVEDLGVLPSGHLEISASGVEDLSRLPSGGEELETSASGVGDLSGLPSGREGLEISASGAGDLSGLTSGKEDLTGSASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDLSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGEASGLSSGAELSGQASGSPEISGETSGLFGVSGQPSGFPDISGETSGLLEVSGQISGVTELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGIPDLVSSAVSGSGESSGIMFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEAGLSGTSGLVDVSGLSSGAIDSSGFTPQPPEFSGLPSGVTEVSGEASGAASGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGTPSGAPDMSGDHLGSLDQSGLQSGLVEPRGEPASTPYFSGDFSGATDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPITYTPQLFESSGEASVSGDV----PRFPGSGVEASPVPESSGETSAYPEAEVGASAAPEARGGASGSPNLSETTSTFHEADLEGTSGLGASGSPSAFPEGPTEGLATPEVSGESTTAFDVSVEASGLASGDRTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEETQTADTATSSTSIPTSTGGTDDSTDIDECLSSPCLNGATCVDAIDSFTCLCLPSYQGDMCEIDQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTVACGEPPVVEHARIFGQKKDRYEINALVRYQCTEGFIQRHVPTIRCQPSGHWEEPRITCTDPATYKRRLQKRSSRPLRRSRPSTAH >XP_014377588.1 aggrecan core protein [Alligator sinensis] MTTLLLVIVYLRVITAAFSVSDNGDGLEVRIPEQSPLKVVLGNSLIIPCYFSDPIDYDT----ISPLTPRIKWSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNYPAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQDTIEVIVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIHFPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTGELYLAWKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYVNQTGYPHPHTRYDAICYTGEDFEGVPENFTDETAGEAFTIQTVTRTEVELPLPHNVTEEEARGSIA-TLGPI-DITPTASELYEGFTVTPGTAETAFTEAENVTEEATPVWAIPEEATPELESASAFTVEEQIVQVTAAPDIALIPEQPISPTGVVFHYRPATNRYSLNFVQAQQACLDNNAVIATPEQLQAAYEAGFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGVRTYGMRPASEMYDVYCYIDRLKGEVFFATQPGQFTFQEAREYCESQNFTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVTPRAACGGDKPGVRTIYLNPNQTGFPDPLSRHHAYCFRAL---PSLQEVEGATPFFE---EDLIATQVIPGVEEVPSGEETTVETELATGPENQTEWGAEVFPTDISLLSVSPSVFPPVSAIPEETSAEASVSGV---SGDISASGEPQISGEPTI-------------SGWVSGAVSGEPA-----SGIFEPSGEPSGIGESGMPSADLDISGL-------LSGESGLPSG------------------------------------------------------------------IDVSGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------PSGEEDLAVSASGIPDISGMPSGEE---------------------ISELPEISGLPSGFSGEVSGVELTSGLPSG--EESGLPSGIPTVYIDHTTLVEVVTTAAEREQEGKGVIGVSGEGDLSGLPSAEWDISGKISGFPSGADISGEPSGIPDISGAPSGIPDISGLPSGV---------------------DISGMPSGIPDISGLPSGI-----------DISGAPSGIPDI----SGFVDLSGLVSGG--------DESGEPSGITFINASVVEVTPSITEAEAKEILEISGLPSGEEDISGASGILDVSGLPSGLVDFSGDVSGMPEISGLPSGIPDISGEISGVEVSSGQPSGVYDYSGLQSGLPTISLVDTTLVEVVTQTSVAQEAGEGPSGVLEISGLPSGERETSGEVSGMVDISGLPSGTVDISGEPSSVPYFSGDISGVTDLSGLTSAVTEVSGEESGLPEVTLITEVVTKPTVSQELGGETAVT-VPHIFEASGDASASGESSAETSALPEISPETSTAYEISGETSAFPEAATESSTAREISGETSALPEISIETSTVHETGGETSAVHETSGETSALPEISDETSALPEISIETATVHETSSETSTDTSGTHTHIPDISGPDIVISTSIPDVELTQEPKGPEEAQLEIESSTPMVSGQETETAAVLETLLLPQVSQEATDVP-----CDENPCGAG-TCQERDGGITCLCPPGYMGDRCDIDLEDCEVGWTKFQGHCYRHFEERETWVDAETRCREHQAHLSSIITPEEQDFVNNHAQDYQWIGLSDRAVEHDFRWSDGNSLQYENWRPNQPDNFFATGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSMVRYQCNQGFIQRHVPTIRCQPNGHWEEPRIACINPSTYQRRLYKRSSRNRSRTNGRAVH >XP_019333446.1 PREDICTED: aggrecan core protein isoform X1 [Alligator mississippiensis] MTTLLLVFVYLRVITAAFSVSDNGDGLEVRIPEQSPLKVVLGNSLIIPCYFSDPIDYDT----ISPLTPRIKWSRLSDGKEVVLLVATDGKVRINTEYKEVISMPNYPAIPTDASLEIKALRSNDSGIYRCGVMHGIEDRQDTIEVIVKGVVFHYRAISTRYTLNFEKAKQACIQNSAVIATPEQLQAAYEDGFEQCDAGWLADQTVRYPIHFPRERCYGDKDEFPGVRTYGVRETDETYDVYCYAEEIKGQVFYATSPAKFTFQEAAEKCHSLGARLATTGELYLAWKGGMDVCSAGWLADQSVRYPISKARPNCGGNLVGVRTVYLYVNQTGYPHPHTRYDAICYTGEDFEGVPENFTDETAGEAFTIQTVTRTEVELPLPYNVTEEEARGSIA-TLGPI-DITPTASELYEGFTVTPGTAETAFTEAENVTEEATPVWAIPEEATPELESASAFTVEEQIVQVTAAPDIALIPEQPISPTGVVFHYRPATNRYSLNFVQAQQACLDNNAVIATPEQLQAAYEAGFDQCDAGWLRDQTVRYPIVTPRSRCVGDKDSSPGIRTYGMRPASEMYDVYCYIDRLNGEVFFATQPGQFTFQEAQEYCESQNSTLASTGQLQAAWKLGLDRCHAGWLADGSLRYPIVTPRAACGGDKPGVRTIYLNPNQTGFPDPLSRHHAYCFRAL---PSLQEVEGATPFFE---EDLIATQVIPGVEEVPSGEETTVETELATGPENQTEWGTEVFPTDISLLSVSPSVFPPVSAIPEETSAEASVSGV---SGDISASGEPQISGEPTI-------------SGWVSGAVSGEPA-----SGIFEPSGEPSGIGESGMPSADLDISGL-------LSGESGLPSG------------------------------------------------------------------IDVSGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------PSGEEDLAVSASGIPDISGMPSGEE---------------------ISELPEISGLPSGFSGEVSGVELTSGLPSG--EESGLPSGIPTVYIDHTTLVEVVTTAAEREQEGKGVIGVSGEGDLSGLPSAEWDISGKISGFPSGADISGEPSAIPDISGAPSGIPDISGLPSGV---------------------DISGMPSGIPDISGLPSGI-----------DISGAPSGIPDI----SGFVDLSGLVSGG--------DESGEPSGITFINASVVEVTPSITEAEAKEILEISGLPSGEEDISGASGILDVSGLPSGLVDFSGDVSGMPEISGLPSGIPDISGEISGVEVSSGQPSGVYDYSGLQSGLPTISLVDTTLVEVVTQTSVTQEAGEGPSGVLEISGLPSGERETSGEVSGMVDISGLPSGTADISGEPSSVPYFSGDISGVTDLSGLTSAVTEVSGEESGLPEVTLITEVVTKPTVSQELGGETAVT-VPHIFEASGDASASGESSGETSALPEISPETSTAYEISGETSAFPEAATESSTAREISGETSALPEISIETSTVHETSGETSAVHETSGETSALPEISSETSTLPEISIETATVHESSGETSTDTSGTHTHIPDISGPDIVISTSIPDVELTQEPKGPEEAQLEIESSTPMVSGQETETAAVLETLLLPQVSQEATDVPIDIDECHSSPCLNGATCVDGIDSFKCLCLPSYGGDLCEIDLEDCEVGWTKFQGHCYRHFEERETWVDAETRCREHQAHLSSIITPEEQDFVNNHAQDYQWIGLSDRAVEHDFRWSDGNSLQYENWRPNQPDNFFATGEDCVVMIWHEQGEWNDVPCNYHLPFTCKKGTVACGDPPVVENARTFGRKKDRYEINSMVRYQCNQGFIQRHVPTIRCQPNGHWEEPRIACINPSTYQRRLYKRSSRNRSRTNGRAVH >XP_020765043.1 aggrecan core protein [Odocoileus virginianus texanus] MTTLLLVFVTLRVIAAAISVSEPDNSLSVSIPEPSPLRVLLGSSLTIPCYFIDPMHPVTTAPSTAPLAPRIKWSRISKEKEVVLLVATEGRVRVNSAYQDKVTLPNYPAIPSDATLEIQNLRSNDSGIYRCEVMHGIEDSQATLEVVVKGIVFHYRAISTRYTLDFDRAQRACLQNSAIIATPEQLQAAYEDGFHQCDAGWLADQTVRYPIHTPREGCYGDKDEFPGVRTYGIRDTNETYDVYCFAEEMEGEVFYATSPEKFTFQEAANECRRLGARLATTGQLYLAWQGGMDMCSAGWLADRSVRYPISKARPNCGGNLLGVRTVYLHANQTGYPDPSSRYDAICYTGEDFVDIPENFFGVGGEEDITIQTVTWPDVELPLPRNITEGEARGNVILTAKPEFEVSPTVPEPEEPFTFVPEVRATAFPAVENRTGEATRPWAFPGESTPGLEAPTAFTSEDLVVQVTLAPGAAEVPGQPRLPGGVVFHYRPGSSRYSLTFEEAKQACLRTGAVIASPEQLQAAYEAGYEQCDAGWLQDQTVRYPIVSPRTPCVGDKDSSPGVRTYGVRPPSETYDVYCYVDRLEGEVFFATRLEQFTFREAQEFCESQNATLATTGQLYAAWSRGLDKCYAGWLSDGSLRYPIVTPRPACGGDKPGVRTVYLYPNQTGLLDPLSRHHAFCFRGVSVTPSPGEEEGSTPTAGPDVEDWIVTQVGPGVAAVPVGEETTATPGFTVEPENKTEWELAYTPAGTFPLPGIPPTWPPTGAATEEHTEGPSATEVPSASEKPFPSEEPFPSEEPSTLSAPVPSRTELPSSGEASGVVSGDFTGSGEISGHLDLSGQPSGESASGLPSEDLDSSGLTSTVGSGLPVESGLPSGEEERITWTSAPKIDRLPSGGEGPEVSASGVELEISASGVEDLSRLPSGEGP--------EISASGVEDLSGLPSGLEISASGVEDLSRLPSGEGPEISASGVEDLSGLPSGGPEVSVSGAEDLSGLPSGGEGPEVSVSGAEDLSGLPGEVPEVSASGVEDFSR------------DLSRLPSGEGPEVSASGVEDLGILPSGHLEISASGVEDLSRLPSGGEDLETSASGVGDLSGLPSGREGLEISASGAGDLSGLISGKEDLTESASGALDLGRIPSVTLGSGQAPEASGLPSGFSGEYSGVDLGSGPSSGLPDFSGLPSGFPTVSLVDTTLVEVVTATTAGELEGRGTIDISGAGETSGLPFSELDISGGASGLSSGAELSGQASGSPDISGETSGFFGVSGQPSGFPDISGETSGLL----------ELSGLPSGQPEISGEASGILSGLGPPFGITDLSGEAPGIPDLSGQPSGLPEFSGTTSGVPDLVSSAMSGSGESSGITFVDTSLVEVTTTFKEEEGLGSVELSGLPSGEADLSGTSGLVDVSGLSSGAIDSSGFTSQPPEFSGLPSGVTEVSGEASRAESGSSLPSGAYDSSGLPSGFPTVSFVDRTLVESVTQAPTAQEAGEGPSGILELSGAPSGAPDMSGDHLGSLDQSGLQSGQVEPSGEPASTPYFSGDFSGTTDVSGESSAATSTSGEASGLPEVTLITEGVTEPTVSQELGQRPPVTYTPQLFESSGEASASGDV----PRFPGSGIEASSVPESSGEMSAYPKAEVGASAAPEASGGASGSPDLSETTSTFHEADLEGASGLGASGSSSAFPQGPTEGLATPEVSGESTTTFDVSVEASGLASGDKTDSGDLSGLDIVISTTIPESEWTQQTQRPAEARLEIESSSPVHSGEESQTADTATSPTSIPTSAGGTDDST--------------------------------------DQKLCEEGWTKFQGHCYRHFPDRATWVDAESQCRKQQSHLSSIVTPEEQEFVNNNAQDYQWIGLNDKTIEGDFRWSDGHSLQFENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYQLPFTCKKGTA-------------------------------------------------------------ATYKRKLQKRSSQPLRRSRPSTAH >XP_040198337.1 aggrecan core protein isoform X1 [Rana temporaria] MTTLLLVFVCLRVIAAAISVSDHANTLSVSIPEEAPLNVLLGHSVTIPCYFINAVEHLTVAPSTAPLSPRIKWSRHNKGHETVLLVATNSQIRVTEAYKGRISLPNYPLIPTDVSLEIVNLLSSDSGVYRCEIMHGIEDSQDTVTLNVKGIVFHYRAISTRYTLDFENAKKACIQNNAVIATPEQLQSAYDDGYHQCDAGWLSDQTVRYPIHNPREPCYGDKEMFPGVRTYGVRETDETYDVYCYAEHMEGEVFYATSPGKYTFHEAEKQCQNLGARLATTGELYLAWQTGMDVCSAGWLADRSVRYPISYKRPNCGGNLVGVRTVYLHPNQTGYPDPLSRYDAICYKDD--------------AENITIQTVTQPGLELIFQRNVTEEEARGSIA-TLEGL-DFTLTPSE--DSFTATPVLVPTEAP-LENITDDGLQLWL---EAVPSVEATG--TVEGEVVPVTAAIDA-AQPGKPISETGVVFHYRAGSSRYSLNFNQAKQACLNNHAAITTPAQLQAAYEAGFDQCDAGWISDQTVRYPIVQPRENCNGDKNGFPGVRNYGVVNPDEQYDVYCYIDKLRGQVFFATQPDHFTFQQAQEFCESKNATLASTGQLYSAWKSGFDKCRAGWLSDGSVRYPIVTPRKVCGGDQSGVRTVYLYANQTGFPDPLSKYNAFCFR-----PSLFEEEEEVPGTPSIEEEIIATKLYPVVEGLPSGEEITVETVTATEFENETDWLLNATALPTVELEVRPSAIPPVAAVPEDVSGEASVSGA---SGIPSGE----VSGEP---------------SGEVSGVISGEPSASGLVSG--EGSGEPSGI--SGFSSGDIS---------------SGLPSG------------------------------------------------------------------IDTSGLP-----------------------------------------------------------------------------------------------------------------------------------------------------------------SGFPSGDELISGSASGFPDISGLTSA----------------------------DMSGLPSGVSGEASGVELVSGLPSGFEDFSGLPSGFPTILHVDTVWTEGITKSPDTEAEGKGTTEFSASGDISGLPSTDF------SGLASGLELSGEPSGL-DFSGRPSGFFEVSGEVSGI-DMSGFSSGIEESSGDPSGISEESGDISGAKEFSGDISGIFSG--------DLSGSGSGLIDFSGEIDISGEISGASGDISGVSSGTFDESGESSGVTLIDGILVESTPSEKEEEGKGSVEESGLFSGELDISGLSGIIDISGEASGADDISGEASGAGFISGLPSGIDDISGEASGAGFISGLPSGIDDISGLTSGFPTISHIDLTLVEVPTIGPDTEEAGQGPSGVFEISGFPSGE--TSTEASGIIDLSGFPSG--ETSTEASGIIDLSG-FPSGTQESGDGSGI-----HTSGIPDIKLITEAVTEPTVSQELAG---VT-SPYII----DASASGDISGEGPL---------TIPDISGEPSGIPL----------------------------------------TSGEPESFVEGSTEAST--------------------DISGHQTSANDVSGPDIVISTSQPESEISLDQKEPEEAKKDTELSAS-ASGDITEDVPLEVVTPKPQAIPDVTEVEIDIDECLPSPCVNGATCVDGIDSFKCLCLPSYGGDLCQIDIEVCDEGWTKFQGHCYQHFSNRETWVDAENTCRSHQSHLSSILSSEEQEFVNGNAQDYQWIGLNDKTVENDFRWSDGNPLQYENWRPNQPDNFFATGEDCVVMIWHEKGEWNDVPCNYHLPFTCKKGTVACGDPPVVENAYTLGRTKERYEITSLVRYQCNQGFLQRHVPIIRCLSSGQWEEPRIQCINPSTYRHR---RSPRRRPKSADKDTH >tr|F1R511|F1R511_DANRE Aggrecan b OS=Danio rerio OX=7955 GN=acanb PE=4 SV=3 GTSLYLI-------------CLENSTLSVSIPVEQPLRPLLGGSMVIPCYFQDITLQDPGSPTNAPLSQRIKWSHIHKGKISLILVATEGQVQVETEYLDRVHLVNYPMVPSDATIEISELRSHDSGTYRCEVMQGIDDNYDSVEMQIQGIVFHYRAISTRYTLTFEMAKAACIQNSAVIATPAQLQAAYDDGFHQCDAGWLSDQTVRYPIHEPREPCYGDKDNFPGVRTYGVRDVNETYDVYCFAEKMSGRVFYSMSVEKFTFADAEDQCAKLGAQLATTGQLYLAWKTGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPYPDSRYDAICYEED----------------KVLIKTTPFPEIYTYTEQVTTEGEVRGQIL-TDEPF-NTTSTESPLSPPLNITDV-------------------------------------EEDIINVATAPPSLHAIPSINAKIKGVVFHYRAESGRYAYTYEEAQDACQKLGAVIATPELLQAAYEAGLHQCSAGWLQDQTVRYPIVHPRKKCSGDSEDVPGVRSYNVRPAHEQYDVYCYMDQIKGEIFHVSSLAGFTYYEAVAHCRKLSSTLASTGELYAAWNQGFHKCSPGWLADRSVRYPVGSPDFDCGGNKTGVQTIYAQPNQTGSPHPYSRYDAYCFKGITA-------------------QCVFVQV----------------------------------------------FHPIVPPLFVDMSGSGSG-------------------------------------SGYASASTSG--------SGSDSASGSASGV--PDSSSGYIS---------------SGIASG------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SGQSGDGSGFLV---------YQEGTD----------ALMWS--SASGSASEAKDG----------------------------SGSGIII-TSGI------------------------------------QSGDQESGEESGHFAVASGLPSGLGSGI-------SGSG-------TSGFFSG----------------EESSGSGF-FSVSFVDTKMIDLTRAFGEQ------ELSGFYTAE--------------------------------SGFPSG----SGSFSGFETGSAI------------------------------------------GFESNSAFGSGSGFETGSAIGFESNSASASGFESSSGSASG---FGSGIASGIESS--PASAF-GSGSASGF-----------------------------------GSSSAIGLESS--------------------------------------------------------------------------------------------------------SASGFKSVVTGTSG----YPNHP-----------------------------------------------------APFDPCDPNPCGQGLCSLQDGVAL-CQCHSGFSGENCSMLVQGCAEGWMEFMGSCYIHFDERETWTSAEQHCQELNSHLVSISSQQEQEFVKTQAQDYQWIGLNDKDVQNEFRWTDGSPLEYENWRPNQPDNYFSTGEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCTTPPEVQNARMLGNSKDRYPVNSFIRYQCNSGFTQRHLSVVRCLPDGQWEKPRVECIRGI-ENNRLRKRSLYIRPKAVNSRTL >tr|E7F537|E7F537_DANRE Aggrecan a OS=Danio rerio OX=7955 GN=acana PE=4 SV=3 MLSLLLLSMCLWVFSATASFTEPESPLRVSIPNELPLRPLMGDTLVLPCYFQDNTVNDPGAPTIAPLSHRIKWSLVTKEKTTNILVASEGIVSIEKRYMDRITLVGYPMTPTDASIKITELHSNDSGVYRCEVMQGIEDSHDIVDVQVQGIVFHYRAITTRYTLNFEKAKAACIQNSAVIATPEQLQAAYDEGFHQCDAGWLADQTVRYPIHDPREACYGDKYEFPGVRTYGVRDVNETYDVYCFAERMTGKVFHTTSPNKFTFEEAEAQCSKLGAKLATTGQLYLAWKGGMDVCNAGWLADRSVRYPINIARPQCGGGLLGVRTVYLFPNQTGYPHPDSRYDAFCYSETGDEGLDLELTTDGDNGVLTVDTITESH-TVISKPASTESEVQGEVV-TYKPS-VTTSVENPY-TALDISHV------------------------------------LPSPPTSSVEKDPDFSQSNKTEMSATGVVFHYRGGNSRYPFGFVEAQLACKSIGAVIASAQQLQAAYEAGYHQCDAGWLSDQTVRYPIVSPRHQCSGDMEQVPGVRSYGLRPADERYDVYCYVDKLRGQVFHASSFEGFTYGEAVAHCQGQNASLASTAHLYAAWKQGFDKCRAGWLLDRSVRYSINIPRQQCGGGRTGVHTVYLFPNQTGSPDLHSKFDAYCFKEDL--------------------------------DLPLNESESQETV--------TEKIVSISSHPAL---HRPEGTPIIAPSPTEPSGTEESVAS--------------SSGDLL-----------------SSGS----------PSGSSVSSGDSSGT--SSTDDLLTS---------------SGDQSG-----------------SGSS----VTSG------ASGTDSLFS-------------------------SGSGDR----SSG-------------SFSSSG--DFSG-----------------------------------------------ASGTDDLLG--------SGSG--------------------------------PSGSF--------------------VSSGDFSGA-------SGSGDMSS---------------------------------GSGSSSG-SGSGLDILV---------TFSGID----------TVFSGVGSTSGQLEEAGEGSTEILTF----------DQISGSGSGLGSGSGYSSEESGS------------------------------------TSDLSSSSGESGESGDLSGISSGSGFSE-------ESSG-------FSGFASGIFP-SGGSSDI-----SFIDGSG----IIMVDRPWMKISFLTEQELGSGQVDFS----GSGLFSG---------------------------SGVSGDISGLSGEISGS-------------SGDSSG----ISSDISGMSGDISGMSGDISGISGD-ITGMSGDLSGMS--SSDHSGSG--SGLASGFTDLTQEASGLVFFGSGEGSGFRSGGYAI----ESGERSGDSDVIFFSEMSNKPLQGMELGR--------------GEVEYSGTVR---------------------------------------------------------------------------------------------------------LSSGSGDDSVFISG----IPVTANTPSVKSTDPPPAELFDQGPSSDTAGHLGPYLKPEEIINNLPLAALSSTTETADYLNPCEPNPCGAGVCSVKDGVGL-CHCPPGLHGEECQFDSHSCEKGWTKFQGNCYLHFSKRETWLDAEQRCRDLNAHLVSINTPEEQAFVNSNAQDYQWIGLNDKTVENDFRWSDGTQLQFENWRPNQPDNYFNSEEDCVVMIWHENGQWNDVPCNYHLPFTCKSGPVTCDKPPKVENAKMFGNKKERYQVNSIIRYQCSENFTQRHPPVIRCMADGQWEKPKVQCIPKVKFG--LHDKSVHHSHKARTALEL >XP_038065741.1 fibropellin-3-like [Patiria miniata] ------------------------------------------------------------MAKLCPKSGYTNWG---------------------------------PGLPDN---------------------YGYED---------------------------------C--------------AYMDPGFYGAGGNW--------------------------------------NDVWCF------------------------------------------------------------QY----------------------------------YNYICKK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITPSSCDDKPCQNSGVCTDGTGGYQCKCKAGYTGKTCQED-NYCQSGWNHYGDFCYRHFDDRHTWQGALARCQSDGANLVSIHSKDESNFIFDHSRGRFWIGLTDQEREGFFKWSDGTKLDFINWSPRIPDN--AGNEDCAIDSVYFGSQWSDVWCGQIYGYVCKKAAED------IDECKSQPCQNDGTCVDLINDYRCDAGYDGKECALTTCL-------PGFVCVDGINSCCCMATKSMT----------V
PhyML tree of selected proteins (((((XP_021145604_1_aggrecan_core_protein_isoform_X1__Columba_livia_:0.08697,(XP_019475050_1_aggrecan_core_protein__Meleagris_gallopavo_:0.02464599,XP_015147464_2_aggrecan_core_protein_isoform_X1__Gallus_gallus_:0.02213726):0.07667193):0.14779824,(XP_019333446_1_PREDICTED__aggrecan_core_protein_isoform_X1__Alligator_mississippiensis_:0.00336869,XP_014377588_1_aggrecan_core_protein__Alligator_sinensis_:0.0190799):0.12370295):0.185237,(((XP_008249943_1_PREDICTED__aggrecan_core_protein_isoform_X1__Oryctolagus_cuniculus_:0.1938161,(XP_024088629_1_LOW_QUALITY_PROTEIN__aggrecan_core_protein__Pongo_abelii_:0.0172307,(XP_018865821_2_LOW_QUALITY_PROTEIN__aggrecan_core_protein__Gorilla_gorilla_gorilla_:0.01168023,((XP_034795266_1_aggrecan_core_protein_isoform_X1__Pan_paniscus_:0.00369866,XP_003952775_3_LOW_QUALITY_PROTEIN__aggrecan_core_protein__Pan_troglodytes_:0.00476382):0.00058505,(XP_038065741_1_fibropellin_3_like__Patiria_miniata_:7.48202077,sp_P16112_PGCA_HUMAN_Aggrecan_core_protein_OS_Homo_sapiens_OX_9606_GN_ACAN_PE_1_SV_3:0.00357292):0.00377095):0.00266257):0.00761521):0.08821039):0.01616077,(NP_001348429_1_aggrecan_core_protein_isoform_1_precursor__Mus_musculus_:0.04258075,XP_038956962_1_aggrecan_core_protein_isoform_X1__Rattus_norvegicus_:0.0452156):0.16313001):0.01782371,((NP_001106926_3_aggrecan_core_protein_precursor__Canis_lupus_familiaris_:0.05515427,XP_023110702_1_LOW_QUALITY_PROTEIN__aggrecan_core_protein__Felis_catus_:0.05265276):0.03670308,(XP_020953956_1_aggrecan_core_protein_isoform_X1__Sus_scrofa_:0.07739937,((XP_024837356_1_aggrecan_core_protein_isoform_X1__Bos_taurus_:0.02094683,(XP_027812861_1_aggrecan_core_protein_isoform_X1__Ovis_aries_:0.00784778,XP_017922102_1_PREDICTED__aggrecan_core_protein__Capra_hircus_:0.01492611):0.01352872):0.00333636,(XP_020765043_1_aggrecan_core_protein__Odocoileus_virginianus_texanus_:0.01304229,((KAB0369135_1_hypothetical_protein_FD755_019140__Muntiacus_reevesi_:0.00902328,KAB0352492_1_hypothetical_protein_FD754_017349__Muntiacus_muntjak_:0.01214426):0.00902644,(OWK08890_1_ACAN__Cervus_elaphus_hippelaphus_:0.00114369,(XP_043345769_1_aggrecan_core_protein_isoform_X7__Cervus_canadensis_:0.00000001,KAF4017792_1_hypothetical_protein_G4228_009467__Cervus_hanglu_yarkandensis_:0.0012485):0.00089327):0.00998149):0.001201):0.00783344):0.04736699):0.03051667):0.01825892):0.34985713):0.16759649,(XP_040198337_1_aggrecan_core_protein_isoform_X1__Rana_temporaria_:0.26506072,XP_041442785_1_aggrecan_core_protein_isoform_X2__Xenopus_laevis_:0.40488173):0.13714005):0.80495565,tr_F1R511_F1R511_DANRE_Aggrecan_b_OS_Danio_rerio_OX_7955_GN_acanb_PE_4_SV_3:0.87064538,(tr_E7F537_E7F537_DANRE_Aggrecan_a_OS_Danio_rerio_OX_7955_GN_acana_PE_4_SV_3:0.64052397,(XP_030269061_1_aggrecan_core_protein_like_isoform_X2__Sparus_aurata_:0.20735723,(KAF7212766_1_aggrecan_core_protein_like__Nothobranchius_furzeri_:0.2917257,XP_023807578_1_aggrecan_core_protein__Oryzias_latipes_:0.8522698):0.16360162):0.28895692):0.17979927);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)