PB0065

DATABASE

Click here to access PB0065 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0065	P35442	Thrombospondin-2	THBS2	TSP2	Homo_sapiens	Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties.

Domains

Gene Ontology

PF00090 (3_TSP_1) PF00093 (VWC) PF02412 (6_TSP_3) PF05735 (TSP_C) PF07645 (EGF_CA) PF12947 (EGF_3)

GO:0005201 (enables) extracellular matrix structural constituent GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008201 (enables) heparin binding GO:0007155 (involved in) cell adhesion GO:0016525 (involved in) negative regulation of angiogenesis GO:0051965 (involved in) positive regulation of synapse assembly GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0031012 (located in) extracellular matrix GO:0031091 (located in) platelet alpha granule GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P35442|TSP2_HUMAN Thrombospondin-2 OS=Homo sapiens OX=9606 GN=THBS2 PE=1 SV=2 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >tr|E7F1S4|E7F1S4_DANRE Thrombospondin 2b OS=Danio rerio OX=7955 GN=thbs2b PE=3 SV=1 MILRRCFRLLALLLLFTSVKSQDAQLEDETIFDLFESSGITRKTIGVKLFKGLDSDAPAY RFIRFDQLPSVSSTALQQLLLQIQNNEGFILTATLRQDRTSRGTILALEGPGERRQLEIV SDGRTNTLDLVYWWADGSRNVISFEEVDLSDSQWKNITLYVHGETATLYIGCGLIDSFIL DEPFYEHLSATGASMFVAKGSTRESHFRGLLQNVRFIFDTQLEDILESRGCDLGNPVEAN KVSESAEFVEVPSSIATNVIGQNTDVPATSSSELMCERSCEELANLFQELKGLRVVVSNL IDGLQKVTEENTAMKEALNKMQSLSEQSMCWQDGRMFEDKEDWIVDSCTKCTCQEGKVVC RQITCPPVACANPSFIDGECCPVCLPMDSEDGWSPWSEWTQCTVTCGSGTQQRGRSCDDT SNTCSGPSIQTRKCSLGKCDRRVRQDGGWSLWSPWSSCSVTCGEGLITRIRHCNAPVPQR GGKDCEGEGRETQSCHTDPCPIDGGWGPWSPWAACSATCGGGLKSRVRECNSPEPQHGGR KCLGDSIENEVCNRLECPIDGCLSNPCFSGVECNTASDGSWECGPCPNGYRGNGTSCEDV NECNMVSDLCHKVGGLQQCVNTDPGFHCLPCPPRYKGTQPYGMGVESAKTNKQVCEPYNP CKDNSHSCHKFAECIFLSHFTDPMYKCECRIGYAGDGIICGEDFDLDGWPNQDLVCGANA TYHCKKDNCPTLPNSGQEDFDNDGQGDACDKDDDNDEIVDERDNCPLMYNPRQYDYDKDD VGDRCDNCPYEHNPAQTDTDNNGEGDACSVDMDGDEILNERDNCPLIYNTDQKDTDLDGV GDQCDNCPLVHNPQQTDSDNDLVGDQCDNNQDIDEDGHQNNMDNCPYIPNANQADHDGDG KGDACDFDDDNDGIPDDRDNCRLVPNKDQEDSDGDGRGEACENDFDNDNVPDIFDACPEN SGISVTDFRKFQMVHLDPKGTTQIDPNWVVRNQGKELVQTANSDPGIAVGFDEFSAVDFS GTFYVNTDRDDDYAGFVFGYQSSRRFYVVMWKQITQTYWEEKPSKAFGISGVSLKVVNST TGTGEILRNALWHTGNTKHQVRTLWHDPKNIGWKDFTAYRWHLIHRPKTGFIRVVVYEGK QIMADSGPVYDKTFAGGRLGLFVFSQEAVFFSDLKYECRDN >tr|F8W5Z7|F8W5Z7_DANRE Thrombospondin 2a OS=Danio rerio OX=7955 GN=thbs2a PE=3 SV=1 MILRSNLCLWPLLLLCIRALPQDGLVEDESIFDLFKISGISRKTIGAKLFKGHDWDSPAY RFIRFDHIPAVSTPALHQILKQVQNNEGFVFVATMRQDKGSRGTLLGVEGPGGLRQLEIV SNGRANTLDLVYMVKGSQNVVSFEDVDLSDSQWKNISLYVHGENAHLYVGCSLIDSVILD EPFYELLRPEGSQMFVAKGSIRENHFRGLLQNVQFLFDTPIENILRNKGCEIAKPEEVNV VNESTESVSVGTSISTNFIGEKEKIASDVCERSCEELSNMVQELKGLRIIVGNLIDGLQK VTEENTVMKEVLGNMKNIKDKRMCWQDGRLFEDKEDWVVDSCTKCTCQESKIVCHQITCP PVACASPTFLDGECCPLCLPKDSEDGWSPWSEWTECTVTCGTGTQQRGRSCDATSNPCSG PSIQTRRCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNSPVPQLGGKDCE GSGRETQKCEAKPCPIDGAWGPWSPWAVCSVTCGGGTRTRTRVCNSPRPQYGGKKCPGDS VDTNACNKQDCPVDGCLSNPCFGGVECTSSPDGSWECGPCPLGFRGNGKVCEDVNECDMV PDLCYKVGDSQRCVNTDPGFHCLPCPPRYKGNQPFGMGVEAAKLNKQVCEQENPCKEKTH NCHRSAECIYLGHFSEPMFKCECKIGYAGDGLICGEDSDLDGWPNQNLVCGANQSYHCKK DNCPKLPNSGQEDFDKDGQGDACDKDDDNDGIMDETDNCPLLYNPRQFDYDKDLVGDRCD NCPYEHNPAQIDTDGNGEGDACAVDIDGDEVLNENDNCPYMYNTDQKDTDMDGVGDQCDN CPLLHNPEQTDSDNDRVGDECDNNQDIDEDGHQNSLDNCPYIPNANQADHDKDGKGDACD SDDDNDGVPDDKDNCRLVPNKDQRDSDGDGRGDACKDDFDNDSIPDFMDVCPENDAISNT DFRKFQMVHLDPKGTAQIDPNWVVRHQGKELVQTANSDPGIAVGFDEFNAVDFSGTFYVN TDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEDNPSKAIGISGVSLKVVNSTTGTGEH LRNALWHTGDTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADS GPVYDQTFAGGRLGLFVFSQELVYFSDLKYECRDN
Selected proteins from model organisms >sp|P35442|TSP2_HUMAN Thrombospondin-2 OS=Homo sapiens OX=9606 GN=THBS2 PE=1 SV=2 MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRF DYIPPVNADDLSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGP ADTLDLTYWIDGTRHVVSLEDVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFY EHLQAEKSRMYVAKGSARESHFRGLLQNVHLVFENSVEDILSKKGCQQGQGAEINAISEN TETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQELSGLHVLVNQLSENLKRVSND NQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTICHQITCPPATC ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSG RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQER QMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDI CFSTSKVPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCH KHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNC PHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCP YVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDD DNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFR NFQMVPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDR DDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRN ALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPI YDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_038078580.1 thrombospondin-1-like isoform X1 [Patiria miniata] MPTRATMARLTYYVFAFGFLCSALHCQLTKAYEEVDVMLASGISARTPGVRETKTPEGGRAFKVRPKDRDLGTDQGSLER LLRSMKADEGFILITVAYQDPKNRGTLVSVDRTDGQVRGFGFHIDRRNDEAVVQFAEFGAGEPQESQVVFSPLNIGKDDT ELHTFVLDVRGNLVTLYMDCQLIGLKILPSSFYMNMEPDNMKLRLGKGLPDRNNVLDFKGTLAVAKFAFQTSTTDVLISQ GCEIEPVFSSSQISFGSSFPLPIGESEPSHISSDAAMPGGEGNVEQSTPNNNNHGDSGSFGNSGLSDSMSFGGAIPVPPG GSFSNLNPGVPSSTGGTSGNVMPQPVPGTPPHLPTNMGYMHPNAAPTDDTMQGQCAYTCEQISNLNNQVQVLSDGYDDMW NKLEHFENQRPPEWPSQQGCWYMKTLYDDGDVFKVDKCKSCECRVEGGLPTVECSLIKCQPGKCANPIIMEGDCCPTCPN DNLGWSDWAEWTSCSVTCGNGIQQRGRSCDRTQFECNGNDVETRVCYLDPCIEIVDGGWSNFTPWSCGVTCGNGTESRMR SCNSPRPKNGGKRCDGELDGAGREERPCGRDPCPVDGQWGQFSEFTPCTKTCDGGWQERYRFCDSPPPAHGGRDCVGSDT HRRMCNEWPCPIDACLSSPCFDGVECVSFTDGRYECKDCPVGYTGNGILCQDINECLLVSDACFNFHGEHRCLNLIPGYT CRKCPIGYRGNQPSGMGVYHAKRYKQQCIPINPCAEGTSSCHIDARCIFYGPYSDPQYGCKCKTGFAGDGVHCGYDSDLD GWPDEQLDCEDHGDYTHCTRDNCASLPNSGQEDNDGDGKGDACDADDDDDLVDDVADNCQFISNWQQFDIDDDGVGDVCD NCPFVSNTRQEDTDSDGDGDVCDYDIDEDGIYNEDDNCMYVANARQLDFDEDGYGDVCDNCPDYGNPDQMDIDDDNVGDV CDTDRDVDNDGHQDDLDNCWNIANSDQADHDMDGIGDACDFDDDNDGIEDVDDNCRLIFNPSQNDTNENGRGDACEYDND GDGVTDLQDACPDNANIQRTDLSHFQLIKLDPEGSAQIDPHWIVRNRGQELVQTINSDPGLAIGYDEFNSVEFSGTFYVN TERDDDYAGFVFGYQSNHRFYSVMWKQVTQKYWEPMPTMSEATAGLQLKLINSTTGPGEYLRNALWHTGDTSDQVKLIWS DANKIGWKDFTAYRWILTHRPRTGYIRVTMYEGSKVLADSGALYDFTLQGGRIGLFCFSQEMVFFSDLQYKCLAEE >XP_030855692.1 thrombospondin-1 [Strongylocentrotus purpuratus] MEKIRCFSCFVLFIATLLPAIIAQSSYVEFNVLQDVGISAASPGVDLVRGQEENSVAYKIKPNKGDMAANTIDVQRLGDA MNDEDGFVLVAKVKMGQKARGTVVSLDGHGHTDRLFGLVIDRKSDSVLMPYSYRRDGVTTQDSLEFSGLNLEDTEDRDWH TFTLDIQGNLAILYADCTRVGLQIMYGSFVYDVTPDQYSLRLGKGLKGRKDVPDFKGIIEDVKFIFGQRGTRILRLQGCD IEASSSQSSSSDISPDFGGQSHDSQLSPFGGGHESIPDVGVGVGVGVGVGVGVGVGPLVSQPNIHPSVHEVETPEQETIA PVPPKMPEVPTVPNTPHTAIEPGVVEGPLNDGSPMNYNLPSLYLPNSPGSHNFAEPTNGARPMPNMNDVIPNGQCAITCD QISQLRNMVDVLSQGQENILTRVTDMDNRIPSQTPPWLDGCFYKNEIRQNFEEWKDDACTTCECNAPAVTCRLIECQPIT CQNPIIKPGECCPQCPNEEQGWSDWTEWTSCSVTCGSGTMQRGRSCDRMRYPCNGRSVETRNCIRDSCVSVVDGGWSNWT PWACGITCGVGTETRVRSCNSPPPQNGGARCLGEAFGAGREERLCQRDPCPVDGAWGEWSLWTACTHSCDGGNQERYRFC DSPTPAHGGRNCSGIKRQEQMCNQRPCPIDGCLSSPCFEGVDCRSSDDGVFQCGPCPVGFRGDGQSCTDVNECLEVLNTC FHHHSQHRCINKIPGYSCQECPTGYRGNQPNGIGIFHASRYRQQCIPINPCTEGTHDCAPDAKCTFFGPYSQPQYGCRCR TGYAGDGYACGLDSDLDGRPDVDLDCQGLGDYMHCHKDNCPRLPNSGQEDSDRDGEGDACDDDDDDDGIRDDRDNCQFTP NRWQGDRDRDKVGDECDNCPTHSNPRQENVDGDEFGDECDDDIDNDGHDNFIDNCPKHANANQDDSDHDGLGDLCDNCPF DFNPLQIDTDDDNVGDECDTDEDVDGDGHQDNLDNCPDIPNASQKDHDNDGIGDACDPDDDNDGVTDADDNCRLVFNPSQ NDTDENGRGDACESDFDGDGVADIMDACPENSMIQRTDLSAFQMVPMDPSGASQLEPNWMVRNHGLELVQTINSDPGLAV GYDEFESVEFSGTFYVNTAKDDDYAGFIFGYQSNHRFYAVMWKQVTQKYWQPDPSPAEATAGLQLKLINSTTGPGEYLRN AMWHTGDTENQVKLIWSDPNKIGWKDFTAYRWTVQHRPIDGFMQVTAWEGSNVLADSGPLYDSTLRGGRLGLYCFSQEMV FFSDMEYRCLSDY >XP_039248576.1 thrombospondin-1-like [Styela clava] MKILQVLLAALACTAAAAELGDKVHDVFTMTNFLSKMREHGISKYVRQTDSYNNFLPAYRFRRPTTTLDLTAVDSQFRSL AEDISQNQEFVLLMSLRNDFTKKGTLLSVTPKDEIDTSGDFLEIVTDPVKGHLSVFGFSQNKKFVHAFETGDLQQEGAWT NFSLWVTTTKMTLYHNCDYVGQFSHNDTLIPMFDVNKNALHLATGFKKAKSFRGSLARIRFYVGATVAEVLAQETRCTRD EHTKLSRDTFEDIGAPGVQPKSSSVSLLSDTDSKSSNNMVCDLSCDDIRKLASVRPPSDYYEGKPVEVMDFPRKSCWDDT VRYDDGEQWKRDDCQVCNCTAGKVTCVVEKCNALPCIDVVEVEGQCCPECASEAIGYSQWSEWTACSVTCGIGQQQRGRA CDKVHFTCDLKTKESRNCVLEPCDRKVKLDGGWSYWSPWGPCSVSCGEGVNTRIRECNAPAPQLGGKDCEGASRENRVCS QPHCPIDGEWGPYSPYSLCSATCGEGTKERTRTCDNPAPMYGGKYCSGKETDTVTCNDKPCPIHGKWSPWSKYGPCTASC GRGQKTRVRSCNNPAPEHGGEYCEGDSSEVRDCKGDPCPIDGGWGPYTPFSRCSATCGGGFKKRTRECNNPAPLFGGKYC VGDKTNIESCSEKTCPINNCLRNPCYPGVTCTPHDDGSYECGTCPEGMQGDGGQCEDIDECKLVPDACFHYEGKHRCQNY PGGYSCMPCPMGHKGDIPTGTGVEYAIAHKQECVVSNPCTDGTNPCSENAECIFLDPTITPPFMCKCHPGYSSFPECRGF VCLEDADLDGIPDVDSSCMKDGVNITLKGDNCLNLPNSGQENADGDEFGDACDRDADNDGIVNERDNCPLIHNPTQHDSD RDGFGDVCDNCPFVRNPGQIDTDNDGLGDECDPDIDGDEILNSDDNCPYVHNPNQRDTDKDGVGDACDNCPNVINKDQSD ADSDLVGDACDTDLDRDKDGVQDDLDNCPFVPNSGQADHDKDRIGDECDNDDDNDGILDKDDNCRLIHNPDQKDSDGNGR GDVCEEDFDGDNIKDFEDACMDNALITKTDFTHFDMVKLDPTGTAQIDPNWVIRNKGKEIIQTKNCDPGLAVGKDMFNGV DFEGTFYVNTGNDDDYAGFVFGYQSSSRFYVLMWKQKTQSYWRAYPRQANAEAGLQLKVVESTTGPGEYLRNALWHTGDT PGQVRTLWTDSMHQGWQDHSAYRWTLNHRPETGEIRVTMYNGKKLLTDSGRIIDRTYAGGRMGMFIFSQEMVFYSDMKYK CSDSKINYK >CAE1249094.1 THBS2S [Sepia pharaonis] MIALIAPADAQFRPLRKPEIGAAFMRYNELSLVGEIQLQSNRRRGRATLLRAENLAMNTKFDSYIDFQRAEVVINLKTKD GREYAVRFLTGVLSENKNKKIIIRFTNLQSNSNGIQLFVNCMNAGRDNTELPIRDVLMGNFSVQRHPAFKLYGQASLKEL LMMQGCEDTENIAPTRPSIPKPSLPSWVGSIDPDRRFPDIDIKRETHSREVSQDPFYTVDQIKTDRIHHSTIDSVKPELP NAIVELTIAIRDLQRDFQNQIRETHLLKETLKECQMCRGTPPEPGNLRRCSSNPCFQGVRCIDTEEGFRCGSCPPGFYGD GKTCSAYLTCNDRPCYPGVQCSDTSSGFICGPCPTTLTGDGTVHGCHPTRVTCDSSPCFPGVMCTDQRTGFHCGSCPTGY TGNGTYCEDLDECQFSRPCDRRATCTNLSPGFTCTPCPQGYTSSPITGIGILSAQQTRQICQDIDECRSNNGGCVPHSRC INTRGSFRCSECDPGYSGNQTVGCRRQISNCSNGKECHKNARCIQRPESSTHECQCSIGYGGDGYYCSKDQDLDGIPDNA LPCGHRKCRKDNCVSTPNSGQEDADGDGLGDACDPDADNDGIVNNPDNCPLVANPDQDDTEDKPDRKGDACDNCPTIPNP EQTDTDDDGMGDTCDPDADNDGIINAHDNCIRVKNADQRDTDGDGIGDACDNCPFVPNVKQLDSDADLTGDACDTNDDKD DDGVQDTNDNCPHIANSDQLDTDGDTLGDICDNDDDNDGVLDVNDNCPLRMNPRQEDEDGNGVGDICEIDKDGDGSEDFI DVCPHNGNIYATDFRAYQTVILDPEGDSQIDPNWVILNQGAEIVQTMNSDPGIAISYTAFAGVDFSGTFYVNTEVDDDYA GFIFSYQDSSHFYVVMWKKNTQTYWHSTPFRAVAEPGIQLKLVNSSTGPGQYLRNALWHTGDTHDQVRLLWKDPRNEGWK ERKAYRWELIHRPYKGLIRILFFEETELIADSGNIYDFTLKGGRLGVFCFSQEMVIWSDLVYRCNDYIPPGLLEEEDYGY GQ >AAK55517.1 putative thrombospondin [Drosophila melanogaster] MNWTRVLLIGLTALALTFVEVASLSLDPVASAELEQFIRKGDVVISTRHIRPRRKLHISIEALFMIDFPMLKHKMSFFLD RKQQRVTLDISANGATESRNFEIPNINETSTIRSLALQFSKNRITLHVDCKASTHHDIDMNLAKLYTQMDDPVIKLFRER KYPLHFDGDMEHSLQRANCQKGNHRRGNRRMLRNKITEREKNKKRDVRGWYEPTIAREGVVDHRHQEVPTDVERGDIPVL NGDCEDALARSLSDLLALVKLLREDVAHQRQEIAYLRMLLENCAGCKNPLTTDNQLRIEPDCRSANPCYPGVECLDSAAG PRCGHCPLGFIGDGKSCKPGVTCAHHMCYPGVQCHDTVNGAQCDSCPAGYEGDGRTCSLRNPCLDTPCPSGAQCLQVGYP PYFHCISCPMGHEVNGTSCRDMNECLLYDPCDELATCTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDE CRTGFFRCPEHSTCINEIGSYRCQCHEGYVTNGTYSCLDRSSVFMCPDGTVCDRNAVCLRMDNIRHKCHCNVGWAGNGLI CGRDTDVDGWPDQAIGCPELHCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVG DVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDF VGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCE DDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEIVQTLNSDPGLAVGKDAFGGVDFDGT FYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEAR LLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVFCFSQRMIIWSNLQYKCNNRV KPLIYNDLSDYLKTKVELQD >XP_397221.5 cartilage oligomeric matrix protein isoform X1 [Apis mellifera] MRVIITLIITIFFLVYVVDSSITRDEDLEKNLRERWNDDFVIVFSNIKSKKKQFQVMVEVLLTIKYEKSKMVLMLDRRAK RVILENIDEVGHRVAQYINMDNLNVNSNFPSKNVIFLVHQSQPGARMAVYIDCIYRGVIPLKKTFRELTNSEDNLLIEAF RERKSQVKVYPLARSMEALQEENCLSTLTDTNTESQELRSIDDNNNFETPSFNSARVNLRNKQNHHVHRSKEHNHDETVD LFEDTDQIDLNSRQSNHNRHSVRDRSNRYKHENDRNKYLEFDQDFSSLMKRLQQPEYFNEPIQEKFEVLSNLNESDILNQ PINIYHKRVPRRGDIGIQSLDERVCLTDNQIVKTLNELIGATKKIWREIELNRLETHRVLLLIENCAACREPPPVPLTTT TPAPPSCSYKSPCFPGSECRDTPRGPQCGACPPDYTGDGYRCVKITCAHNPCFKGVRCYDQSDRYSCGNCPIGYIGNGKH CELKNVCEPNPCYSEVQCDLISEPPFYRCGVCPNGFTGNGSVCVDINECEIAQPCSLGVQCINLHPGFRCDPCPPGYTGT MIEGVGLEIAMNRKQICQDINECENNNGGCDPYMECINMQGSYRCGACRAGFIGNQTVGCHPAHSICPDLITRCDVNAEC VCIDTNVYSCRCRVGWTGDGLICGIDRDNDGIPDRNLHCRDRHCRMDNCPLTPNSGQEDADRDGIGDACDPDADDDGVLN SSDNCPFISNPGQEDNDSDGPDLVGDICDNCPRVRNPKQEDTDDDGIGDACDPDIDNDGIPNNQDNCQKIKNQNQNDMDE DGIGDACDNCPYGYNPNQLDQDGDGVGDDCDNDNDRDRDGVQDDRDNCPDVANSGQNDDDHDGIGNECDNDMDNDGVPNS NDNCPYVYNPDQRHTHNNFIGDACWHDYDNDTVKNIHDNCPNNSLIWATDFRKYTTIALDPFGTAQEDPVWVIHNDGAEI QQLVNSDPGIAIGPDIFSGVDFEGTFFVDDDGDDDFVGFVFSYQDNRRFYIVAWKKAHQPYWVPTPFRAVGDPGIYLKLV DSDTGPGEILRNSLWHNENTINQVKILWHDPKKIGWKERTSYRWQLLHRPKIGLIRFRLYQGKQLMADSGNVYDSTLKGG KLGVYCFSQEKITWSNLLYVCKETVPLSVWNDLPSNLRKEINVDINNEIKSQYSQKSIYYDSH >XP_031556620.1 cartilage oligomeric matrix protein-like [Actinia tenebrosa] MKKSGSIWYLQSLLVLLSMVLNTEAKIQDFDLIKSFELGKGQITGLGRIEGYPGEPEEAYRFDRGLARLHLGPEFVSDLA EASRESKSLTITSNLKLDRKSYGTLLSIETEGEGNLVFSLLFSCFSSCRISLYYPEGSLTSVTYFDKVPNISDGKWHKMV LHIQTNRMGKHVVSLFMDCRSLGKKKISAGLDQLFPLSNEKVKYALRFAQRGASNSVYIPWKGSLQSVLLIFGVRSHSFA NPVDCLTKSTRQILSGLTNKNNRHKYQPTVKVVTTQRRQTTSKDATTVKSTPTKPQKDGTTKPQPSVRPITQKEKPTRNI VDIITSGETRFGVADGSSPTTELVLTTSDEKLDYLVDMIRQLKKEQFHRESALRKTIEMLRIDLNSQSQEVRYVRSFLEH GGACKSGSLIQQTGKRFDSIGTILPGRKTDRQNPVAGGKCLQKPCFPFVECYETPDEGLGFRCGPCPPGFTGNGIRCEDV NECNLYPCSALTKCINLRPGYQCTPCPVGYLGNASMGLGVEMARKNKQVCEDINECANGRNGGCSIHSECINTQGSYRCG PCKPGYDGDSTRECKRVLFCSNAPRANPCGKLAHCIPRNDGRNYECKCKPGYGGDGVRCGKDSDMDGYPDRALGCKGPKC AKDNCREIPNSGQEDVDGDGTGDACEYDADGDRKPSKDQDNCPSVPNEDQQDTDADGVGDACDNCQTVNNPDQEDTDKDG IGDACDVDIDGDGIINVLDNCPKVPNRDQKNTDGDPHGDACDNCKRGKNPDQADKDGDGIGDVCDFDQDYDRDGVDDRHD NCLRKPNAAQLDTDGDGLGDVCDSDDDNDGIPDYKDNCRLVRNVDQKDSDNDGIGDACQGDYDNDGVPDAVDICPYNHNI TKTDFSSFFNVNFDPLSKIKDYPQWKASKKGNEVYLRKNSNVGLFVATPKYEDIEFRGTMFVNTHQDDDIIGFAFGYQQY GHFFLLSWKRKEQMYWIVNPFRATAKTWLTLKRVKSSSVPSHGIRNALWHTAETRRHTKVLWQKRLTRGWKPKTAYRWEL NYTPSNGYLRLQMWVGTQQLMDTGILRDLEMRGGRLGFFSFSQGDIIWSDLQVRCVDGK >NP_001361951.1 Peptidase M12B domain-containing protein [Caenorhabditis elegans] MPPFYIVITFLLSTVFRISQSVHHHLNEEELKQVFGVSNKHDVPEYSLIEATRHPLKNGNLKMKFTAWNDTYHLNLRKNS RIVSPHIISVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFLVLQTLPKRVHHLQKERH LVYKRSAGLLTNAESKIREEITRLQEEQESFCDTSEQLDDPAMTHLHFNYTIPTSAQLDSSFIFPNMDPITLEIGLFLDS KLFEHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGVHKNGQAQSLLDAFCRYQ AHMNPGTDLTDMNHYDHGVLLTGYDIYHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMGHNMGMVHDGVQN QCNKGCCLMSAVNGAGKTTWSDCSVREFNAFLLQLDESGRGNCLRDASPGLISTNHLSDLRLPGQRFTADQQCSYFWGRD YKVEIPNGKAMDDICRILWCGNSGSTISTAHPALEGSWCGANKWCHKGQCTHWTFGLTPVPIDGEWSEWGGAEKGCPIQQ CAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGIVCGATSSNCLGFTREEFGNKICSSIKYDPHKPDQQLTGEGFEHS TQPCRVWCHLIGSELIRNKGQFPDGTPCGFDAYCVGGQCLALSCDNKALVEQPEDCPRIEGRSVHQWEEWSSWSECSVSC GLGGREVRERKCSSGRKCQGVSEESRPCEGVLRDCEEFGEWKEWGSCSEKCALGVQKRFRPCLTDQCSSKHLQEERPCDN EGCWTNWDEWSSCSQSCGGGRRYRIRKCLDDKCDGDDLEKESCNTQKCISQSWGDWLPCSVSCGIGFQIRERLCDGELCA TANKQARTCNQQQCPSAFSLSVWSEWGEWTTCSATCGEGLQSRERSCRRGSCTEDDASQTRRCVNGPCEHSYLTWSEWTT CETCSSFDSRKRIAKCDGTTENCQDKIDEETCDIACLREKHSFGPISPRRPKLITSNDLRKAFGRPLLPIESIHSEKWSE WGPCSVTCGSGRRVRTRGCQEASCPEQHIQTEECNLNSCLELFIWSDWSSCSKSCGQDGIQTRQKLCLFNNAECSSYAES RRCKDLPSCSSISSGRTISENGFDAPRWSEWSSWSACSCFSLTSTRRRFCQVVDPTVQGFCAGAILEQIPCAPGSCSPSA GGWSLWSEWSSCSKDCGDTGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDNVCSDEKVDGGWTDWTAWSECTDYCRN GHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPARCHLRDGGWSTWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQSCS GLAHQTSLCDLPACDHESDGEWSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSPSTALCSSF ITSSHLADGYFIDTDQQQ >tr|E7F1S4|E7F1S4_DANRE Thrombospondin 2b OS=Danio rerio OX=7955 GN=thbs2b PE=3 SV=1 MILRRCFRLLALLLLFTSVKSQDAQLEDETIFDLFESSGITRKTIGVKLFKGLDSDAPAY RFIRFDQLPSVSSTALQQLLLQIQNNEGFILTATLRQDRTSRGTILALEGPGERRQLEIV SDGRTNTLDLVYWWADGSRNVISFEEVDLSDSQWKNITLYVHGETATLYIGCGLIDSFIL DEPFYEHLSATGASMFVAKGSTRESHFRGLLQNVRFIFDTQLEDILESRGCDLGNPVEAN KVSESAEFVEVPSSIATNVIGQNTDVPATSSSELMCERSCEELANLFQELKGLRVVVSNL IDGLQKVTEENTAMKEALNKMQSLSEQSMCWQDGRMFEDKEDWIVDSCTKCTCQEGKVVC RQITCPPVACANPSFIDGECCPVCLPMDSEDGWSPWSEWTQCTVTCGSGTQQRGRSCDDT SNTCSGPSIQTRKCSLGKCDRRVRQDGGWSLWSPWSSCSVTCGEGLITRIRHCNAPVPQR GGKDCEGEGRETQSCHTDPCPIDGGWGPWSPWAACSATCGGGLKSRVRECNSPEPQHGGR KCLGDSIENEVCNRLECPIDGCLSNPCFSGVECNTASDGSWECGPCPNGYRGNGTSCEDV NECNMVSDLCHKVGGLQQCVNTDPGFHCLPCPPRYKGTQPYGMGVESAKTNKQVCEPYNP CKDNSHSCHKFAECIFLSHFTDPMYKCECRIGYAGDGIICGEDFDLDGWPNQDLVCGANA TYHCKKDNCPTLPNSGQEDFDNDGQGDACDKDDDNDEIVDERDNCPLMYNPRQYDYDKDD VGDRCDNCPYEHNPAQTDTDNNGEGDACSVDMDGDEILNERDNCPLIYNTDQKDTDLDGV GDQCDNCPLVHNPQQTDSDNDLVGDQCDNNQDIDEDGHQNNMDNCPYIPNANQADHDGDG KGDACDFDDDNDGIPDDRDNCRLVPNKDQEDSDGDGRGEACENDFDNDNVPDIFDACPEN SGISVTDFRKFQMVHLDPKGTTQIDPNWVVRNQGKELVQTANSDPGIAVGFDEFSAVDFS GTFYVNTDRDDDYAGFVFGYQSSRRFYVVMWKQITQTYWEEKPSKAFGISGVSLKVVNST TGTGEILRNALWHTGNTKHQVRTLWHDPKNIGWKDFTAYRWHLIHRPKTGFIRVVVYEGK QIMADSGPVYDKTFAGGRLGLFVFSQEAVFFSDLKYECRDN >tr|F8W5Z7|F8W5Z7_DANRE Thrombospondin 2a OS=Danio rerio OX=7955 GN=thbs2a PE=3 SV=1 MILRSNLCLWPLLLLCIRALPQDGLVEDESIFDLFKISGISRKTIGAKLFKGHDWDSPAY RFIRFDHIPAVSTPALHQILKQVQNNEGFVFVATMRQDKGSRGTLLGVEGPGGLRQLEIV SNGRANTLDLVYMVKGSQNVVSFEDVDLSDSQWKNISLYVHGENAHLYVGCSLIDSVILD EPFYELLRPEGSQMFVAKGSIRENHFRGLLQNVQFLFDTPIENILRNKGCEIAKPEEVNV VNESTESVSVGTSISTNFIGEKEKIASDVCERSCEELSNMVQELKGLRIIVGNLIDGLQK VTEENTVMKEVLGNMKNIKDKRMCWQDGRLFEDKEDWVVDSCTKCTCQESKIVCHQITCP PVACASPTFLDGECCPLCLPKDSEDGWSPWSEWTECTVTCGTGTQQRGRSCDATSNPCSG PSIQTRRCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNSPVPQLGGKDCE GSGRETQKCEAKPCPIDGAWGPWSPWAVCSVTCGGGTRTRTRVCNSPRPQYGGKKCPGDS VDTNACNKQDCPVDGCLSNPCFGGVECTSSPDGSWECGPCPLGFRGNGKVCEDVNECDMV PDLCYKVGDSQRCVNTDPGFHCLPCPPRYKGNQPFGMGVEAAKLNKQVCEQENPCKEKTH NCHRSAECIYLGHFSEPMFKCECKIGYAGDGLICGEDSDLDGWPNQNLVCGANQSYHCKK DNCPKLPNSGQEDFDKDGQGDACDKDDDNDGIMDETDNCPLLYNPRQFDYDKDLVGDRCD NCPYEHNPAQIDTDGNGEGDACAVDIDGDEVLNENDNCPYMYNTDQKDTDMDGVGDQCDN CPLLHNPEQTDSDNDRVGDECDNNQDIDEDGHQNSLDNCPYIPNANQADHDKDGKGDACD SDDDNDGVPDDKDNCRLVPNKDQRDSDGDGRGDACKDDFDNDSIPDFMDVCPENDAISNT DFRKFQMVHLDPKGTAQIDPNWVVRHQGKELVQTANSDPGIAVGFDEFNAVDFSGTFYVN TDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEDNPSKAIGISGVSLKVVNSTTGTGEH LRNALWHTGDTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADS GPVYDQTFAGGRLGLFVFSQELVYFSDLKYECRDN >NP_035711.2 thrombospondin-2 precursor [Mus musculus] MLWALALLALGIGPRASAGDHVKDTSFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNTDD LNRIVKLARRKEGFFLTAQLKQDRKSRGTLLVLEGPGTSQRQFEIVSNGPGDTLDLNYWVEGNQHTNFLE DVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEPFYEQLEVDRSRMYVAKGASRESHFRGLLQNVH LVFADSVEDILSKKGCQHSQGAEVNTISEHTETLHLSPHITTDLVVQGVEKAQEVCTHSCEELSNMMNEL SGLHVMVNQLSKNLERVSSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWVVDSCTTCTCKKFKTVC HQITCSPATCANPSFVEGECCPSCSHSADSDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKPCQRDP CPIDGRWSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPCFP GAKCNSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDICFSTNKAPRCVNTNPGFHCLPCPPRYKGNQ PFGVGLEDARTEKQVCEPENPCKDKTHSCHKNAECIYLGHFSDPMYKCECQIGYAGDGLICGEDSDLDGW PNNNLVCATNATYHCIKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCQLLFNPRQLDYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL MHNPDQIDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPDDRD NCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKT GYMRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDA >NP_001162609.1 thrombospondin-2 precursor [Rattus norvegicus] MLWALALLALGIGPRAYAGDHGEDTAFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYVPPVNTDD LNRIVKLARRKEGFFLTAQLKQDRKSRGTLLVLEGPGTSQRQFEIVSNGPGDTLDLNYWVEGHQHTNFLE DVGLADSQWKNVTVQVASDTYSLYVGCDLIDSVTLEEPFYEQLEADKSRMYVAKGASRESHFRGLLQNVH LVFADSVEDILSKKGCQHSQGAEVNTISEHTETLHLSPHITTDLVVQGVEKAQEVCTHSCEELSNMMNEL SGLHVMVNQLSKNLERVSSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWVVDSCTTCTCKKFKTVC NQITCSPATCANPSLVEGECCPSCSHSADNDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKACQRAP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPCFP GAKCNSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVADICFSINKASRCVNTNPGFHCLPCPPRYKGTQ PFGIGLEDAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNSNLVCATNATYHCVKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCPLLFNPRQLDYDKD EVGDRCDNCPYVHNQAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL MHNPDQMDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPDDRD NCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKT GYMRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDA >NP_789861.1 thrombospondin-2 precursor [Bos taurus] MLWPLLLLALWAWPSAQAGDQDEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSAEH LGRITEAMRRKEGFFLTASMKQDRRSRGTLLALEGPGATHRQFEIVSNGPADTLDLTYWVDGTQHVISLE DVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEPFYEHLQTERSRMYVTKGAARESHFRGLLQNVY LVFENSVEDLLSKKGCQQSQGAETNAISENTETLHLSPMVTMEHVGPSAEKSPEVCEHSCEELGSMIREL SGLHVIVNQLHENLRKVSNDNQFLWELIGGPPKTRNVSACWQDGRFFAENETWVVDSCTKCTCKKFKTVC HQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQT RACSLGRCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCP VDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGGAKEQQMCNRKSCPIDGCLSNPCFPGA ECSSFPDGSWSCGSCPGGFLGNGTHCEDLDECAVVTDVCFATSKAHRCVNTNPGYHCLPCPPRYKGNQPF GVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPN KNLVCATNATYHCVKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVSDEKDNCQLLFNPRQFDYDKDEV GDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVH NPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPHIPNANQADHDRDGQGDACDSDDDNDGIPDDRDNC RLVANPDQEDSDGDRRGDACKDDFDNDSIPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIR HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWED QPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGY IRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_015139537.2 thrombospondin-2 isoform X1 [Gallus gallus] MCDGGRAPRSAPQRRQRPGSRQSPLVPSALLMPGVMLQRSRLLWLAVFITLWVSSDAQDDAKEENTFDLL QISNINRKTIGAKLFRGPDPAIPAYRFIRFDHIPPFKPEKLKKIVKLIRQNEGFILSATLRQDRQSRGTI LALEGPGISERQFEIISNGRANTLDLIYWVDGFQNVISLEDVDLADSQWKNLTVQVTGENYNLYVGCDLI DSFILEEPFYEQLKAENSRMYVAKGSIRENHFRGLLQNIHLIFDTSIEDVLRKKGCQRSQSTEVNTINES TEILHLSPAVTTEYVGEKTEKKAEFCDRSCEELGTMFTELTGLRIVVNNLADNLQKVSEENQIMWELIGP NKTLKNQSVCWQDGRVFADSESWIVDSCTKCTCQDSKIVCHQITCPPVSCADPSFIEGECCPVCSHSDDS EEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCS VTCGVGNITRIRLCNSPIPQMGGKNCVGNGRETEKCEKAPCPVNGQWGPWSPWSACTVTCGGGIRERSRL CNSPEPQYGGKPCVGDTKQHDMCNKRDCPIDGCLSNPCFPGAECNSYPDGSWSCGPCPAGFLGNGTVCED LDECIAVSDVCFKVNQVHRCVNTNPGFHCLPCPPRYKGSQPYGVGLEVAKTEKQVCEPENPCKDKTHSCH KSAECIYLGHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNNNLVCAANATYHCVKDNCPLLPNSGQED FDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCA VDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQ NNQDNCPYIPNANQADHDKDGKGDACDPDDDNDGIPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDDDN VPDIFDVCPENNAISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELVQTANSDPGIAVGYDEFSSVDF SGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGTGEHLRN ALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRL GLFVFSQEMVYFSDLKYECRDA >XP_024213293.1 thrombospondin-2 [Pan troglodytes] MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADD LSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLE DVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVH LVFENSLEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQEL SGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTSCTCKKFKTIC HQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFP GAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGNQ PVGVGLDAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRD NCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKT GYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_043312836.1 thrombospondin-2 [Cervus canadensis] MLRPLLLLALWAWSSAQAGDQDEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSAEHLGRIAEAMRR REGFFLTASLKQDRRSRGTLLALEGPGAAHRQFEIVSNGPADTLDLTYWVDGTQHVISLEDVGLADSQWKNVTVQVTGET YSLYVGCDLMDSFALDEPFYEHLQTERSRMYVAKGAARESHFRGLLQNVYLVFENSVEDLLSKKGCQQNQGAEANAISED TETLHLSPMVTMEHVGRSAERGPEVCEHSCEELGSMIRELSGLHVIVSQLHENLRKVSNDNQFLWELIGGPPKTRNMSAC WQDGRFFAENETWVVDSCTKCTCKKFKTVCHQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGSGTQ QRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRE TKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPCFPGA ECSSFPDGSWSCGACPMGFLGNGTHCEDLDECAVVTDVCFATSKAHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTE KQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPL LPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVD IDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNA NQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNF QMVHLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMW KQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGY IRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >KAF4024738.1 hypothetical protein G4228_016622 [Cervus hanglu yarkandensis] MLRPLLLLALWAWSSAQAGDQDEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSAEHLGRIAEAMRR REGFFLTASLKQDRRSRGTLLALEGPGAAHRQFEIVSNGPADTLDLTYWVDGTQHVISLEDVGLADSQWKNVTVQVTGET YSLYVGCDLMDSFTLDEPFYEHLQTERSRMYVAKGAARESHFRGLLQNVYLVFENSVEDLLSKKGCQQNQGAEANAISED TETLHLSPMVTMDHVGRSAERGPEVCEHSCEELGSMIRELSGLHVIVSQLHENLRKVSNDNQFLWELIGGPPKTRNMSAC WQDGRFFAENETWVVDSCTKCTCKKFKTVCHQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGSGTQ QRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRE TKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPCFPGA ECSSFPDGSWSCGACPVGFLGNGTHCEDLDEVGALPRLRGGPRRPGPGLMSSLLVPQCAVVTDVCFATSKAHRCVNTNPG YHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSD LDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRC DNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGD QCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDF DNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYV NTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLW HDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRGECENR GHWGRVSQGTGKECTFCFSFYKSCTSGK >XP_018118557.1 thrombospondin-2 [Xenopus laevis] MLQRKLLLLHILISFGVSIYGQDEEKEDETNFDLFEISNINKRTIGAKIFRGHESSSPAFRFLRFDHIPPVNSEKVKQIT ELMQQNEGFILTATMRQDKHNRGTLIAIEGPGISNRLFELVSNGRANTLDLIYWVDGSQNVISLEDVDLADSQWKNITVQ LLGENFNLYIGCDLIDSFQLEETFYEHLKADNVKMFLAKGSIRGNHFRGLLQDVRLIFDISIEDVLRKKGCQLSHTGEVN TISEKTEILHLSPMTTEYVGQKIEKQIDFCDHSCDELGSMFTELTRLRILVNNLLDNLQKVSEENQVLWELIGPNKTLKN QSMCWQDGRVFADNEDWIVDSCTKCTCQNSKTVCHQITCPPVHCASPSFIDGECCPMCFPMDSEAGWSPWSEWTECSVTC GSGTQQRGRSCDATSSSCEGSSIQTRTCHPGKCDNRIRQDGGWSHWSPWSACSVTCGIGNITRIRLCNSPKPQLGGKNCT GAGRETKQCEGIPCPINGKWGPWSPWSSCTVTCGGGLRERSRLCNNPKPQYGGKKCGGEPKEKEMCNKQDCPIDGCLSNP CFPGAECNSYPDGSWSCGACPVGFVGNGTFCEDLDECALVSDACFQLGGLHRCVNTDPGYHCLPCPPRYKGTQPFGVGIE VAKKDKQECEPINPCKDKSHNCHKYAECIYIGHFSDPSYKCECRTGYAGDGIICGEDSDLDGWPNNNLICAANATYHCIK DNCPLLPNSGQEDFDKDGVGDACDKDDDNDGVDDEKDNCPLLYNPRQFDYDKDEVGDRCDNCVYVHNPAQIDTDNNGEGD ACAADIDGDDILNELDNCPYVYNTNQKDTDMDGVGDQCDNCPLMHNPDQTDVDNDLVGDQCDNNEDIDEDGYQNNLDNCP YIPNANQADHDKDGRGDACDSDDDNDGVPDERDNCRLVYNPDQKDSDGDGRGDACKDDFDNDSIPDIFDVCPENSDISET DFRKFQMVPLDPKGTAQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFSAVDFSGTFYVNTDRDDDYAGFVFGYQSSSRF YVLMWKQVTQTYWEDKPSRAYGYSGVSVKVVNSTTGTGEHLRNALWHTGNTPGEVRTLWHDPKNVGWKDYTAYRWHLTHR PKTGFIRVVVYEGKQIMADSGPLYDKTYAGGRLGLFVFSQEMVYFSDLKYECKDF >OWK09861.1 THBS1 [Cervus elaphus hippelaphus] MPTLPAWQPLTLGSPPRAAGSLLGADSSAMGLAWGLAVLLLSHVCGSSRIPESGGDNSVFDIFELTGAARKGSGRRLVKG PDPSSPAFRIEDANLIPPVPDKKFQDLVDAVRAEKGFLLLASLRQMKKTRGTLLAVERKDHSGQLFSVVSNGKAGTLDLS LTVQGKQHVVSVEEALLATGQWKGITLFVQEDRAQLYIDCEKMENAELDVPIQSIFTRDLASIARLRIAKGGVNDNFQGV LQNVRFVFGTTPEDILRNKGCSSSTSVFLTLDNNVVNGSSPAIRTDYIGHKTKDLQAICGISCDELSSMVLELRGLRTIV TTLQDSIRKVVSGLRPPPTEENKELANELRRPPLCYHNGVQYRTGDEWTVDSCTECRCQNSVTICKKVSCPIMPCSNATV PDGECCPRCWPSDSADDGWSPWSEWTSCSVTCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIHECDKRCVITRIRLCNSP SPQMNGKPCEGKARETKACQKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCIGDVTENQICNKQD CPIDGCLSNPCFAGVQCTSYPDGSWKCGACPPGYSGDGVACKDVDECKEVPDACFNHNGEHRCENTDPGYNCLPCPPRFT GSQPFGRGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNYLGHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNEDLVC VANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQ ADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQKDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDED GHQNNLDNCPYVPNANQADHEKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDQDKVPDIDDI CPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVQTVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGF VFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDF TAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLFVFSQEMVFFSDLKYECRGRSKMTVNIQVESLVQT SIRNASHARG >NP_001184085.1 thrombospondin-2 precursor [Canis lupus familiaris] MLGALVLLALWASSSAQAGDQDEDMAFDLFRISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSADY LSRIAKIVRQKEGFFLTASLKQDPKSRGTLLALEGPGAQRQFEIVSNGPADTLDLTYWIDGTQHVISLED VGLADSQWKNVTVQVTGDTYSLYVGCDLIDSFTLDEPFYEQLRTEKTRMYVAKGSARDSHFRGLLQNVHL VFENSVEDVLSKKGCQQSQGAEANAISENTETLHLSPQGGPEYGGPGAQQRPEVCERSCEELSTMITELS GLHVIVNQLHENLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKKFKTVCH QITCPPATCANPSFVEGECCPSCFHSLDGEEGWSPWAEWTECSTTCGSGTQQRGRSCDVTSNTCLGPSIQ TRACSLGKCDNRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKGCQGVPC PIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQQMCNKRSCPIDGCLSNPCFPG AQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFTTSKAHRCVNTNPGFHCLPCPPRYKGSQP FGVGLEAARTEKQVCEPENPCKDKTHACHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWP NKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVDDEKDNCQLLFNPRQFDYDKDE VGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLV HNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDN CRLVFNPGQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENSAISETDFRNFQMVHLDPKGTTQIDPNWVI RHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWE DQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTG YIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_013847876.1 thrombospondin-2 isoform X1 [Sus scrofa] MGRRQGGSFAGFSLEGSRMLWPLLLLASGAWSSARAGDQDEDTAFDLFSVSNINRKTIGAKQFRGPDPSV PAYRFVRFDYIPPVGAEPLGRIAEAMRRKEGFFLTASLKQDRKSRGTLLALEGPGATRRQFEIVSNGPAD TLDLTYWVDGAQHVISLEDVGLADAQWKNVTVQVTGETYSLYVGCDLMDSFTLDEPFYEQLKTEQSRMYV AKGSARESHFRGLLQNVFLVFENSVEDLLSKKGCRQSQGAEANAISENTETLHLSPPVSTGHVGLGAEKG REVCEHSCEELGSMIQELSGLHVIVSQLHENLRKVSNDNQFLWELIGGPPKTRNVSACWQDGRFFAENET WVVDSCTKCTCRKFKTVCHQITCPPATCADPAFVDGECCPSCFSDGEEGWSPWAEWTECSATCGPGTQQR GRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGR GCKGSGRETRACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQQMCN KRSCPVDGCLSNPCFPGASCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFTTSKAHRCVNTD PGFHCLPCPPRYKGSQPFGVGLEAARTEKQVCEPENPCEDKTHNCHRHAECVYLGHFSDPMFKCECRTGY AGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVSDEKD NCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDSNGEGDACSVDIDGDDVFNERDNCPYVYNTDQR DTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDVDEDGHQNNQDNCPYISNANQADHDHDGKGD ACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENNAISETDFRNFQM VPLDPKGTTQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSS SRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGW KDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_017195335.1 PREDICTED: LOW QUALITY PROTEIN: thrombospondin-2 [Oryctolagus cuniculus] MLWGLALLALWAWQGAQDVRAADPDEDTSFDLFSISNINRKTIGAKQFRGPEPGAPAYRFVRFDYIPPVN AADLLRITRSMRRRDGFFLTAQLKQDRKSRGTLLALEGPGAARQFEVVSNGPADTLDLTYWTDGGQHVLS LEDVGLADSQWKNITVQVAGETFGLYVGCDLIDSFALDEPFYEQLTADRSRMYVAXGAARESHFRGLLQN MHLVFENSVEDVLSKKGCQHGRGAEINAISEHTETLHLSPHLSAEHTGQSLQPRPEVCEHSCAELGNMIS ELSGLHLLVDQLSENLRRVSSDNQFLLELIGVPPKTRNVSGCWQEDRMFAENETWVVDSCTTCTCKKFKT VCHQITCSPATCANPSIVEGECCPSCSHADGEEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPS IQTRACSLSKCDARVRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKSCKGSGRETKACEGA PCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKACVGDVKERQMCNRRSCPVDGCLSNPCF PGAECSSFPDGSWSCGACPVGYLGNGTYCEDLDECAVVTDVCFSTSKTARCINTQPGFHCLPCPPRYKGS QPSGVGLEAARAEKQVCEPENPCKDKTHSCHKQAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDG WPNSNLVCATNATYHCLKDNCPHLPNSGQEDFDKDGVGDACDDDDDNDGVSDEKDNCQLLFNPRQFDYDK DEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCP LMHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYVANANQADHDNDGKGDACDPDDDNDGIPDDR DNCRLLFNPDQEDSDGDGRGDICKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNW VIRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTY WEDQPSRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLTHRPK TGYIRVLVHEGKQVMADSGPIYDHTYSGGRLGLFVFSQEMVYFSDLKYECRDV >XP_024104045.1 thrombospondin-2 [Pongo abelii] MVWRLVLLALWVWPSMEAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGMPAYRFVRFDYIPPVNADD LSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHMVSLE DVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVH LVFENSVEDILSKKGCQQGQGAEINTISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQEL SGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTIC HQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQLGGKNCKGSGRETKACQGAP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKTCVGDVQERQMCNKRSCPVDGCLSNPCFP GAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGSQ PVGVGLEAAKMEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDMDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRD NCRLVFNPDQEDLDGDGRGDICKDDFDNDNVPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKT GYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_003204105.2 thrombospondin-2 [Meleagris gallopavo] MPGVMLQRSRLLWLAVLITLWVSSDAQDDAKEEENTFDLLQISNINRKTIGAKLFRGPDPAIPAYRFIRF DHIPPFKPEKLKKIVKLIRQNEGFILSAILRQDRQSRGTILALEGPGISERQFEIISNGRANTLDLIYWV DGFQNVISLEDVDLADSQWKNLTVQVAGENYNLYVGCDLIDSFILEEPFYEQLKAENSRMYVAKGSIREN HFRGLLQNIHLIFDTSIEDVLRKKGCQRSQSTEVNTINESTEILHLSPAVTTEYVGEKTEKKAEFCDRSC EELGTMFTELTGLRIVVNNLADNLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADSESWIVDSCTK CTCQDSKIVCHQITCPPVSCADPSFIEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDV TRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPIPQMGGKNCVGNG RETEKCEKAPCPVNGQWGPWSPWSACTVTCGGGLRERSRLCNSPEPQYGGKPCVGDTKQHDMCNKRDCPI DGCLSNPCFPGAECNSYPDGSWSCGPCPAGFLGNGTVCEDLDECIAVSDVCFKVNQVHRCVNTNPGFHCL PCPPRYKGSQPYGVGLEVAKTEKQVCEPENPCKDKTHSCHKSAECIYLGHFSDPMYKCECRTGYAGDGHI CGEDSDLDGWPNNNLVCAANATYHCVKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLF NPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDG VGDQCDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDPDD DNDGIPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDNDNVPDIFDVCPENNAISETDFRKFQMVPLDPK GTAQIDPNWVIRHQGKELVQTANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVL MWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAY RWHLIHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRLGLFVFSQEMVYFSDLKYECRDA >XP_003820249.2 thrombospondin-2 [Pan paniscus] MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADD LSKITKIMRQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLE DVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVH LVFENSVEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQEL SGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTSCTCKKFKTIC HQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPCFP GAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKMPRCVNTQPGFHCLPCPPRYRGNQ PVGVGLDAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRD NCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSHFYVVMWKQVTQTYW EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKT GYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_006932208.1 thrombospondin-2 isoform X1 [Felis catus] MLWDLVLLALWAASGARAGDQDEDTAFNLFSISNINRKTIGAKQFRGPDPNVPAYRFVRFDYIPPVSADY LSKIAKIVRQKEGFFLTASLKQDPKSRGTLLALEGPGASQRQFEIVSNGPADTLDLTYWIDGAQHVISLE DVGLADSQWKNITVQVTGETYSLYVGCDLIDSFTLDEPFYEQLRTEKSRMYVAKGSARDNHFRGLLQNIY LVFENSVEDVLSKKGCQQSQGAEANAISENTETLHLSPQVATEYAGPGAHRRPEVCERSCEELGTMITEL SGLHVIVNQLHENLRKVSNDNQVLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKKFKTVC HQITCPPATCANPSFVEGECCPSCFHSLDGEEGWSPWAEWTQCSATCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKGCQGTP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVQERQMCNKRSCPVDGCLSNPCFP GAECSSFPDGSWSCGACPVGFLGNGTHCEDLDECAVVTDVCFAVGKAQRCVNTNPGFHCLPCPPRYKGTQ PFGVGLEAARTEKQVCEPENPCKDKTHACHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNKNLVCSTNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVDDEKDNCQLLFNPRQFDYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDIDNDLVGDQCDNNDDIDDDGHQNNQDNCPYIPNANQADHDHDGQGDACDSDDDNDGVPDDRD NCRLVSNPGQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENSAISETDFRNFQMVHLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EEQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKT GYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_027828484.1 thrombospondin-2 [Ovis aries] MLRPLLLLALWAWSSAQAGDQDEDTAFDLFSLSNINRKTIGAKQFRGPDPHTPAYRFVRFDYIPPVSAEH LGRIAEAMRRKEGFFLTASLKQDRRSRGTLLALEGPGAAHRQFEIVSNGPADTLDLTYWVDGTQHVISLE DVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEPFYEHLQTERSRMYVAKGAARESHFRGLLQNVY LVFENSVEDLLSKKGCQQSQGAEANAISENTETLHLSPMVTMEHVGPSAEKGPEVCEHSCEELGSMIREL SGLHVIVNQLHESLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCRKFKTVC HQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQT RACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRGCKGSGRETAACQGPPCP VDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQQMCNRKSCPVDGCLSNPCFPGA ECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSRAHRCVNTNPGYHCLPCPPRYKGNQPF GVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPN KNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEV GDRCDNCPYVHNPAQIDTDSNGEGDACSADIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVH NPDQTDVDNDLVGDQCDDNEDIDEDGHQNNQDNCPYIPNANQADHDRDGRGDACDSDDDNDGVPDDRDNC RLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIR HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWED QPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGY IRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_018885551.1 thrombospondin-2 [Gorilla gorilla gorilla] MVWRLVLLALWVWPSTQAGHQDKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNADD LSKITKIMQQKEGFFLTAQLKQDGKSRGTLLALEGPGLSQRQFEIVSNGPADTLDLTYWIDGTRHVVSLE DVGLADSQWKNVTVQVAGETYSLHVGCDLIDSFALDEPFYEHLQAEKSRMYVAKGSARESHFRGLLQNVH LVFENSVEDILSKKGCQQGQGAEINAISENTETLRLGPHVTTEYVGPSSERRPEVCERSCEELGNMVQEL SGLHVLVNQLSENLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKKFKTIC HQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSI QTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAP CPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERQMCNKRSCPMDGCLSNPCFP GAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSKVPRCVNTQPGFHCLPCPPRYRGSE PVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGW PNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKD EVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPL VHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRD NCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWV IRHQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYW EDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKT GYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDI >XP_011482880.1 thrombospondin-2 isoform X1 [Oryzias latipes] MKLWRHLFLFLSVFHQAASQDEEQLDETSFDLFEISHITRKTLGAKQFRGQNLDAPAYRFIRFDFLPPVD PPILKQILEQIQNNEGFVFVASMRQDHTSRGTLVALEGPGGRRQFEIISNGPANTLDLVYWVDGSQNVVS FEDVDLSDSQWKNITLHIHGENANLFVGCNLLDSFVLDEPFYEHLRAEGSRMYVAKGSNRENHFRGLLQS VRFIFDTPVESILQNRGCEVIKQDDPNTVRESTEVIDVRPSITTNIIGQKTDDLGSDMCERSCEELSTMF HELKGLRVVVSNLIDGLQKVTEENTVMKEALGRMKETKEKNMCWQDGRLFEDKEDWVVDSCTKCTCQESK IVCHQITCPPVACASPSFVDGECCPVCMPKDSEDGWSPWSEWTECTVTCGIGTQQRGRSCDATSNPCSGP SIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGTDCEGSGRETQNCTA TPCPIDGGWGPWSPWASCSATCGGGIKSRTRECNSPQPQHGGKKCLGEASDSDSCNKKDCPIDGCLSNPC FGGVDCSSSPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVSGTQRCVNTNPGFHCLPCPKRYKG TQPFGMGVESAKRNKQVCEPENPCKDKTHSCHKFAECIYISHFSDPMYKCECRTGYAGDGFICGEDSDLD GWPNQNLVCGANTTYNCQKDNCPDLPNSGQEDFDRDGQGDACDKDDDNDGILDERDNCALLYNPRQFDFD KDEVGDRCDNCPYEHNPAQIDTDHNGEGDACAVDIDGDDIHNDNDNCPYVYNTDQKDTDMDGVGDQCDNC PLLHNPDQSDIDNDLVGDQCDNNQDIDEDGHQNNLDNCPYVANANQADHDKDGKGDACDYDDDNDGVPDD KDNCRLTPNADQVDSDGDGRGDACKDDFDNDSIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDPN WVVRHQGKELVQTANSDPGIAVGFDEFNAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQT YWEYKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLIHRP KTGFIRVVVYEGKQIMADSGPIYDKTFAGGRLGLFVFSQELVFFSDLKYECRDKPEYRTVILKTTEPGWE DNSKRAKEKTPLQ >XP_013224536.2 thrombospondin-2 [Columba livia] MLQRSGLLWLAVLITLWVSSNAQDGDKEEETTFDLLQISNINRKTVGAKLFRGPDPATPAYRFIRFDHIP PCKPEKLKKIVRLIRQNEGFILSATLRQDRQSRGTILALEGPGISERQFEIISNGRANTLDLIYWVDGFQ NVISLEDVDLADSQWKNLTVQITGENYNLYVGCDLIDSFILEEPFYEQLKAENSRMYVAKGSIRENHFRG LLQNIQLIFDTSIEDVLCKKGCQRSQSTEVNTINESTEILHLSPAVTTEYVGEKPEKKAEFCDRSCEELG TMFTELTGLRIVVNNLADNLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADSESWIVDSCTKCTCQ GSKIVCHQITCPAVSCANPSFVEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSA CTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCVGNGRETE KCEKVPCPVNGQWGPWSPWSACTVTCGGGIRERSRLCNSPEPQYGGKPCVGDIKQHDMCNKKDCPIDGCL SNPCFPGAECNSYPDGSWSCGPCPAGYLGNGTICEDLDECIAVSDVCFKVNQVHRCVNTNPGFHCLPCPP RYKGSQPYGVGLEIAKTEKQVCEPENPCKDKTHSCHKSAECIYLGHFSDPMYKCECRTGYAGDGRICGED SDLDGWPNNNLVCAANATYHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQ FDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQ CDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDPDDDNDG VPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDNDSVPDIYDVCPENNAISETDFRKFQMVPLDPKGTAQ IDPNWVIRHQGKELVQTANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQ VTQTYWEDKPTRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHL IHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRLGLFVFSQEMVYFSDLKYECRDA >XP_017908975.1 PREDICTED: thrombospondin-2 [Capra hircus] MLRPLLLLALWAWSSAQAGDQDEDTAFDLFSLSNINRKTIGAKQFRGPDPRTPAYRFVRFDYIPPVSAEH LGRIAEAMRRKEGFFLTASLKQDRRSRGTLLALEGPGAAHRQFEIVSNGPADTLDLTYWVDGTQHVISLE DVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEPFYEHLQTERSRMYVAKGAARESHFRGLLQNVY LVFENSVEDLLSKKGCQQSRGAEANAISENTETLHLSPMVTMEHVGPSAEKGPEVCEHSCEELGSMIREL SGLHVIVNQLHESLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKKFKTVC HQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQT RACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCP VDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDIKEQQMCNRKSCPVDGCLSNPCFPGA ECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSRAHRCVNTNPGYHCLPCPPRYKGNQPF GVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPN KNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEV GDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVH NPDQTDVDNDLVGDQCDDNEDIDEDGHQNNQDNCPYIPNANQADHDRDGRGDACDSDDDNDGVPDDRDNC RLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIR HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWED QPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGY IRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_025050742.1 thrombospondin-2 isoform X1 [Alligator sinensis] MKRGVCARKLAKNNFSNYLAGLIEDITPTQRTLAAYVLRPTRLQPTPPITRVMLLRSSLLWLTFLLTLWA TSNAQDGDKEEETTFDLLQISNINRKTIGAKVFRGPNPTTPAYRFIRFDHIPPVNPEKLKQIIKLLRKNE GFILSATLRQDRQSRGTIIALEGPGTTQRQFEIISNGRANTLDLIYWVDGSQNVISLEDVDLADSQWKNL TVQVTGETYNLYVGCDLIDSFILEEPFYEQLKAENSRMYVTKGSIRENHFRGLLQNVNLIFDISLEEVLR KKGCQRSQTIEVNTINESTEILHLSPAVTTEYVGEKTEKKAEFCDRSCEELGTMFTELTGLRVVVNNLVD NLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADNEIWTVDSCTKCTCQNSKIVCHQITCPAVSCAN PSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSSCTGPHIQTRMCSFKKCEH RIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQMGGKNCEGKGRETEKCEKVPCPINGQWGPWSP WSACTVSCGGGIHERSRLCNSPEPQYGGKPCVGDVKQHDICNKKDCPIDGCLSNPCFPGAECNSYPDGSW SCGACPSGYLGNGTVCEDLDECIAVPDVCFKVNQAHRCVNTNPGFHCLPCPPRYKGTQPFGVGLEVAKAE KQVCEPENPCKDKTHQCHKSAECIYLGHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNKNLVCAANAT YHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYV HNPAQIDTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTDTDND LVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDSDDDNDGVPDDRDNCRLRFNPDQED SDGDGRGDICKDDFDNDSIPDIYDVCPENYDISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELVQTA NSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSG VSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIRVSVYEGKQ VMVDSGPIYDMTFAGGRLGLFVFSQEMVYFSDLKYECKDF >XP_006277456.1 PREDICTED: thrombospondin-2 isoform X1 [Alligator mississippiensis] MPGVMLLRSSLLWLTFLLTLWATSNAQDGDKEEETTFDLLQISNINRKTIGAKVFRGPNPTTPAYRFIRF DHIPPVNPEKLKQIINLLRKNEGFILSATLRQDRQSRGTIIALEGPGTTQRQFEIISNGRANTLDLIYWV DGSQNVISLEDVDLADSQWKNLTVQVTGENYNLYVGCDLIDSFILEEPFYEQLKAENSRMYVTKGSIREN HFRGLLQNVNLIFDISLEEVLRKKGCQRSQTIEVNTINESTEILHLSPAVTTEYIGEKTEKKAEFCDRSC EELGTMFTELTGLRVVVNNLVDNLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADNEIWTVDSCTK CTCQNSKIVCHQITCPAVSCANPSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDV TRSSCTGPHIQTRMCSFKKCEHRIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQMGGKNCEGKG RETEKCERVPCPINGQWGPWSPWSACTVSCGGGIHERSRLCNSPEPQYGGKPCVGDVKQHDICNKKDCPI DGCLSNPCFPGAECNSYPDGSWSCGACPSGYLGNGTVCEDLDECIAVPDVCFKVNQAHRCVNTNPGFHCL PCPPRYKGTQPFGVGLEVAKAEKQVCEPENPCKDKTHQCHKSAECIYLGHFSDPMYKCECRTGYAGDGRI CGEDSDLDGWPNKNLVCAANATYHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLF NPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDG VGDHCDNCPLMHNPDQTDMDNDLVGDQCDNNEDIDDDGHQNNQDNCPYIPNANQADHDKDGKGDACDSDD DNDGVPDDRDNCRLRFNPDQEDSDGDGRGDICKDDFDNDSIPDIYDVCPENYDISETDFRKFQMVPLDPK GTAQIDPNWVIRHQGKELVQTANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVL MWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAY RWHLIHRPKTGLIRVSVYEGKQVMVDSGPIYDMTFAGGRLGLFVFSQEMVYFSDLKYECKDF >XP_015799926.1 PREDICTED: thrombospondin-2 isoform X1 [Nothobranchius furzeri] MILRSSLFLLLLSTFHQVAPQDGEQEDEMSFDLFEISHITRKTLGAKQFRGQNLDAPAYRFIRFDHLPPV STPILKQILRQIQNNEGFVFVASIRQDRGSRGTLIGLDGPDGRRQFEIVSDGRANTLDLVYWVDGSRNVF SFEDVDLSDSQWKNVTLHIHGENANLFVGCSLIDSFILDEPFYENLRAEGSRMFVAKGSTRESHFRGLLQ NVHFLFDTSMEDILLSRDCEVEKQDTDNIVSESTEIVDVRPSTTTNIIGQKTDDLGTDMCERSCEELSTM FQELKGLRVVVSNLIDGLQKVTEENTVMKEALGRMKDSKEKNMCWQDGRLFEDKEDWVVDSCTKCTCQES KIVCHQITCPPVACASPSLIDGECCPVCMPKDSEDGWSPWSEWTECTVTCGIGTQQRGRSCDATSNPCSG PSIQTRKCSLGRCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGKDCAGSGRETQKCI AEPCPIDGAWGPWSPWATCSATCGGGVKSRSRECNSPRPQYGGKKCIGEPNDSDSCNKEDCPIDGCLFNP CFGGVDCSSSPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVSGTQRCVNTDPGFHCLPCPKRYK GTQPYGMGIEAAKRNKQVCEPENPCKEKTHSCHKYAECIYISHFSDPMYKCECRTGYAGDGFICGEDSDL DGWPNQNLVCDANATYHCKKDNCPNLPNSGQEDFDKDGQGDACDKDDDNDGILDDRDNCPLLYNPRQFDF DKDDVGDRCDNCPYEHNPAQIDTDHNGEGDACAVDIDGDEILNENDNCPYVYNTDQKDTDMDGVGDQCDN CPLLHNPDQTDVDNDLVGDQCDNNQDIDEDGYQNNLDNCPYVANANQADHDKDGKGDACDYDDDNDGIPD EKDNCRLTPNEDQLDSDGDGRGDACKDDFDNDNIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDP NWVVRHQGKELVQTANSDPGIAVGFDEFNAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQ TYWEDKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTAGQVRTLWHDPKNIGWKDYTAYRWHLIHR PKTGFIRVVVYEGKQIMADSGPVYDKTFAGGRLGLFVFSQELVFFSDLKYECRDKPQFPEVFTR >XP_020762367.1 thrombospondin-2 [Odocoileus virginianus texanus] MLRPLLLLALWAWSSIQAGDQDEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSAEH LGRIAEAMRRREGFFLTASLKQDRRSRGTLLALEGPGAAHRQFEIVSNGPADTLDLTYWVDGTQHVISLE DVGLADSQWKNVTVQVTGETYSLYVGCDLMDSFALDEPFYEHLQTERSRMYVAKGAARESHFRGLLQNVY LVFENSVEDLLSKKGCQQNQGAEANAISENTETLHLSPMVTMDHVGRSAERGPEVCEHSCEELGSMIREL SGLHVIVNQLHESLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKKFKTVC HQISCPPATCADPWFVEGECCPSCVHDGEEGWSPWAEWTECSATCGPGTQQRGRSCDVTSNTCLGPSIQT RACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRETKACQGPPCP VDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPCFPGA ECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSKAHRCVNTNPGYHCLPCPPRYKGNQPF GVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIYLGHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPN KNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEV GDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVH NPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNC RLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIR HQGKELVQTANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWED QPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGY IRVLVHEGKQVMADSGPIYDQTYAGGRLGLFVFSQEMVYFSDLKYECRDV >XP_030298404.1 thrombospondin-2 isoform X1 [Sparus aurata] MILRRSLFLLLLSFNFLHALPEDGEQEDETSFDLFEISHITRKTLGAKQFRGQNSDAPAYRFIRFDHLPP VSPPILKQILRQIQNNEGFVFAASIRQDRASRGTLIGLEGPDGQRQFEIVSNGRANSLDLVYWVEDSQNV VSFEDVDLSDSQWKNITLHIHGENANLFVGCSLIDSHILDEPFYEHLQAEGSRMYVAKGSIRENHFRGLL QNVRFVFDTPVEDVLLSRDCEVSKQDDANIVSESTEVVDVSPSITTNIIGQKTDDVGADMCERSCEELST MFQELKGLRHVVSNLIDGLQKVTEENSVMKEALGRMKNTKEKNMCWQDGRLFDDKEDWVVDSCTKCTCQE SKIVCHQITCPAVACASPSFVDGECCPVCLHSEDGWSLWSEWTECTVTCGTGTQQRGRSCDATSNPCDGP SIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGKDCEGSGRETQRCTA QPCPIDGGWGPWSPWATCSATCGGGIKTRMRECNSPQPQHGGRKCIGEANDEAGCNKKDCPIDGCLSNPC FGGVDCNSAPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVAGTQRCVNTDPGFHCLPCPKRYKG TQPFGMGVEAAKKNKQVCEPENPCKDKTHNCHKYAECIYISHFSDPMYKCECRTGYAGDGFICGEDSDLD GWPNLNLVCGANATYHCKKDNCPSLPNSGQEDFDKDGQGDACDKDDDNDGILDERDNCPLLYNPRQFDFD KDEVGDRCDNCPYEHNPAQIDTDNNGEGDACAVDIDGDEIMNENDNCPYVYNTEQKDTDMDGVGDQCDNC PLLHNPDQTDVDNDLVGDQCDNNQDIDEDGHQNNLDNCPYVANANQADHDKDGKGDACDYDDDDDGVPDD KDNCRLTPNADQLDSDGDGRGDACKDDFDNDSIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDPN WVVRHQGKELVQTANSDPGIAVGFDEFSAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQT YWEDKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRP KTGFIRVVVYEGKQIMADSGPVYDKTFAGGRLGLFVFSQELVFFSDLKYECRDKPEFPTVFTR >XP_040206850.1 thrombospondin-2 [Rana temporaria] MRLVTKRGVMLQTTLQRLLIFLCFWAFLNAQDEDGEDETTFDLFEISNINKRTIGVKMFRGHDPNSPAYR FLRFDHIPPVKSEKMREIIHLMQLNEGFILTATIKQDKRNRGTLLSIEGPGISNRMFELVSNGRANTLDL IYWIEGTQNVISLEDVDLADSQWKNITVQLTGENFNLYVGCDLMDSFRLEETFYEHLKADNNKMFLARGS IRENHFRGLLQKIKLIFDTPVEDILKKKGCQLGHTGDNAISEKTEMIHLSPLTEYVGKKEDRQIDFCDRS CDELSTMFTELSGLRVVVNNLLDNLQKVSEENQELWELIGPNKTLKNQSVCWQDGRVFGDNEDWIVDSCT KCTCQSSKTVCHQITCPTVHCDSPTFVEGECCPVCFPLDNEAGWSPWSEWTECSVTCGPGTQQRGRSCDA TSSTCAGSSIQTRTCNPGKCDHRIRQDGAWSHWSPWSACSVTCGIGNITRIRLCNSPKPQLGGKNCTGIG RETKECEGVPCPINGKWGPWSPWSSCSVTCGGGLRERSRICNNPKPQYGGKKCGGDTKEKDMCNKQDCPI DGCLSNPCFPGSECNSYPDGSWSCGACPVGYIGNGTFCEDLDECTLVTDACFRLGGVHRCVNTDPGYQCL PCPPRYKGNQPFGVGLEVAQKDKQVCEPINPCKDKSHNCHKSAECIYIGHFSEPSFKCECRTGYAGDGII CGEDSDLDGWPNNNLICAANATYHCVKDNCPLLPNSGQEDFDKDGVGDACDRDDDNDGVDDEKDNCPLLF NPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACAVDIDGDDILNELDNCPYVYNTDQTDTDKDG VGDQCDNCPLMHNPDQTDVDNDLVGDQCDNNEDIDEDGYQNNLDNCPYIPNANQADHDKDGRGDACDSDD DNDGVPDDRDNCRLVFNPDQKDSNGDGRGDECKDDFDNDSIPDIFDVCPENSGISETDFRKFQMVPLDPK GTAQIDPNWVIRHQGKELVQTANSDPGIAVGFDEFSAVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVL MWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGEVRTLWHDPKNVGWKDYTAY RWHLTHRPKTGYIRVVVYEGKLIMADSGPLYDKTYAGGRLGLFVFSQEMVFFSDLKYECKDF
Mafft alignment of selected proteins >sp|P35442|TSP2_HUMAN Thrombospondin-2 OS=Homo sapiens OX=9606 GN=THBS2 PE=1 SV=2 ------------------------------------------------------------ --------MVWRLVLLALWVWPSTQ---AGHQDKDTTFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYIPPVNA-----DDLSKITKIMR---QKEGFFLTAQLK--- -----QDGKSRGTL-LALEGPG---LS--QRQFEIVSNGPADTLDLTY----WIDGTRHV VSLEDV--GL---ADSQWKNVTVQV---------AGET------YSLHVGCDLIDSFALD EP---FYEHLQAE-KSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSV -----------EDILSKKG-CQQGQGA--------EINAIS---------ENTETLRLG- --------------------------------------------------------PHVT TEYVGPS----------------------------------------------------- -----------------SER-RPE----------------VCERSCEELG---------- ------------NMVQEL---------SGLHVLVNQLSENLKRV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTTCTCKK----FKTICHQITCP PATC---ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CALVPDICFSTSKVPR CVNTQPGFHCLPCPPRYRGNQPVGVGLEA--AKTEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNLNLVCATNATY-HCIKDNCPHLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQADYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNANQADHDRDGQG DACDPDDDNDGVPDDRDNCRLVF---------------NPDQEDLDGDGRGDICKDDFDN DNIP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_038078580.1 thrombospondin-1-like isoform X1 [Patiria miniata] MPTR-----------------------------------------------------ATM AR---LTYYVFAFGFLCSALHCQLT-------KAYEEVDVMLASGISAR------TPGVR ETKT-PE-GGRAFKVRPKDRDLGTDQ-----GSLERLLRSMK---ADEGFILITVAY--- -----QDPKNRGTL-VSVDRTD---GQ--VRGFGFHIDRRNDEAVVQFAEFGAGEPQESQ VVFSPL--NI-GKDDTELHTFVLDV---------RGNL------VTLYMDCQLIGLKILP SS---FYMNMEPD-NMKL------RLGKGLPDRN------NVLDFKGTLAV--------- ---------------------------------------------------AKFAFQTST -----------TDVLISQG-CEIEPVF--------SSSQISFGSSFPLPIGESEPSHISS DAAMPGGEGNVEQ--STPNNNNHGDSGSFGNSGLSDSMSFGGAIPVPPGGSFSNLNPGVP SSTGGTSGNVMPQP--------VPGTP----------------------------PHLPT NMGYMHPNAAP------TDDTMQG----------------QCAYTCEQIS---------- ------------NLNNQV---------QVLSDGYDDMWNKLEHF--------ENQRP--- ------PEWPSQQGCWYMKTLYDDG-----DVFKVDKCKSCECRVEGGLPTVECSLIKCQ PGKC---ANPIIMEGDCCPTCP---NDNLGWSDWAEWTSCSVTCGNGIQ---QRGRSCDR TQFECNGNDVETRVCYLDPCIEIV--DGGWSNFTPW-SCGVTCGNGTESRMRSCNSPRPK NGGKRCDGELDGAGREERPC---------------------------------------- ------------------------------------------------------------ --------------GRDPCPVDGQWGQFS------EFTPCTKTCDGGWQERYRF--CDSP PPAHGGRDCVGSDTHRRMCNEWPCPIDACLSSPC-------FDGVECVSFTDG--RYECK DCPVGYTGNGILCQDINE--------------------------CLLVSDACFNFHGEHR CLNLIPGYTCRKCPIGYRGNQPSGMGVYH--AKRYKQQCIPINPCAEG-TSSCHIDARCI --------------FYG------------------------------PYSDPQYGCKCKT GFAG----DGVHCGYDSDLDGWPDEQLDCEDHGDYTHCTRDNCASLPNSGQEDNDGDGKG DACDADDDDD-LVDDV-----ADNCQFISNWQQFDIDD---DGVGDVCDNCPFVSNTRQE DTDSDGDGDVCDYDIDEDGIYNEDDNCMYVANARQLDFDEDGYGDVCDNCPDYGNPDQMD IDDDNVGDVCDTDRDVDNDGHQD---------------DLDNCWNIANSDQADHDMDGIG DACDFDDDNDGIEDVDDNCRLIF---------------NPSQNDTNENGRGDACEYDNDG DGVT--------DLQDACPDN-ANIQRTDLSHFQLIKLDPEGSAQID------PHWIVRN RGQEL--------------VQT----INSDPGLAIGYDEFNSVEFSGTFYVNTER----- -DDDYAGFVFGYQ----------------SNHRFYSVMWKQVTQKYWEP----------- ------MPTMSEATAGLQLKLINSTTGPGEYLRN--ALWHT--------GDTSDQVK--- ---------------------------LIWSDANKIGWKDFTAY---------------R WILTHRPRTGYIRVTMYE---------GSKVLADSG------------------------ ------------------------ALYDFTLQG------------GRIGL-------FCF S-------QEMVFFSDLQYKCLAEE----------------------------------- ----- >XP_030855692.1 thrombospondin-1 [Strongylocentrotus purpuratus] -----------------------------------------------------------M EKIRCFSCFVLFIATLLPAIIAQSS---------YVEFNVLQDVGISAA------SPGVD LVRG-QEENSVAYKIKPNKGDMAANT-----IDVQRLGDAMN---DEDGFVLVAKVK--- -----MGQKARGTV-VSLDGHG---HT--DRLFGLVIDRKSDSVLMPYSYRRDGVTTQDS LEFSGL--NLEDTEDRDWHTFTLDI---------QGNL------AILYADCTRVGLQIMY GS---FVYDVTPD-QYSL------RLGKGLKGRK------DVPDFKGIIED--------- ---------------------------------------------------VKFIFGQRG -----------TRILRLQG-CDIEASS-----------------------SQSSSSDISP DF---GGQSHDSQ--LSPFGGGHESIPDVG-VGVGVGVGVGVGVGVGPLVSQPNIHPSVH EVETPEQETIAPVPPKMPEVPTVPNTPHTAIEPGVVEGPLNDGSPMNYNLPSLYLPNSPG SHNFAEPTNGARPMPNMNDVIPNG----------------QCAITCDQIS---------- ------------QLRNMV---------DVLSQGQENILTRVTDM--------DNRIP--- ----------SQTPPWLDGCFYKNEIRQNFEEWKDDACTTCECNA----PAVTCRLIECQ PITC---QNPIIKPGECCPQCP---NEEQGWSDWTEWTSCSVTCGSGTM---QRGRSCDR MRYPCNGRSVETRNCIRDSCVSVV--DGGWSNWTPW-ACGITCGVGTETRVRSCNSPPPQ NGGARCLGEAFGAGREERLC---------------------------------------- ------------------------------------------------------------ --------------QRDPCPVDGAWGEWS------LWTACTHSCDGGNQERYRF--CDSP TPAHGGRNCSGIKRQEQMCNQRPCPIDGCLSSPC-------FEGVDCRSSDDG--VFQCG PCPVGFRGDGQSCTDVNE--------------------------CLEVLNTCFHHHSQHR CINKIPGYSCQECPTGYRGNQPNGIGIFH--ASRYRQQCIPINPCTEG-THDCAPDAKCT --------------FFG------------------------------PYSQPQYGCRCRT GYAG----DGYACGLDSDLDGRPDVDLDCQGLGDYMHCHKDNCPRLPNSGQEDSDRDGEG DACDDDDDDD-GIRDD-----RDNCQFTPNRWQGDRDR---DKVGDECDNCPTHSNPRQE NVDGDEFGDECDDDIDNDGHDNFIDNCPKHANANQDDSDHDGLGDLCDNCPFDFNPLQID TDDDNVGDECDTDEDVDGDGHQD---------------NLDNCPDIPNASQKDHDNDGIG DACDPDDDNDGVTDADDNCRLVF---------------NPSQNDTDENGRGDACESDFDG DGVA--------DIMDACPEN-SMIQRTDLSAFQMVPMDPSGASQLE------PNWMVRN HGLEL--------------VQT----INSDPGLAVGYDEFESVEFSGTFYVNTAK----- -DDDYAGFIFGYQ----------------SNHRFYAVMWKQVTQKYWQP----------- ------DPSPAEATAGLQLKLINSTTGPGEYLRN--AMWHT--------GDTENQVK--- ---------------------------LIWSDPNKIGWKDFTAY---------------R WTVQHRPIDGFMQVTAWE---------GSNVLADSG------------------------ ------------------------PLYDSTLRG------------GRLGL-------YCF S-------QEMVFFSDMEYRCLSDY----------------------------------- ----- >XP_039248576.1 thrombospondin-1-like [Styela clava] ------------------------------------------------------------ ---------MKILQVLLAALACTAA----AAELGDKVHDVFTMTNFLSKMREHGISKYVR QTDS-YNNFLPAYRFRRPTTTLDLTAV---DSQFRSLAEDIS---QNQEFVLLMSLR--- -----NDFTKKGTL-LSVTPKDEIDTS--GDFLEIVTDPVKGHLSVFG----FSQNKKFV HAFETG--DL--QQEGAWTNFSLWV---------TTTK------MTLYHNCDYVGQFSHN DT---LIPMFDVN-KNAL------HLATGFKKAK------S---FRGSLAR--------- ---------------------------------------------------IRFYVGATV -----------AEVLAQETRCTRDEHT--------KLSRDTF--------EDIGAPGVQ- --------------------------------------------------------PKSS SVSLLSD----------------------------------------------------- -----------------TDSKSSN--------------NMVCDLSCDDIR---------- ------------KLAS-V---------RPPSDYYEGKPVEVMDF---------------- ----------PRKSCWDDTVRYDDG-----EQWKRDDCQVCNCTA----GKVTCVVEKCN ALPC---IDVVEVEGQCCPECA---SEAIGYSQWSEWTACSVTCGIGQQ---QRGRACDK VHFTCDLKTKESRNCVLEPCDRKVKLDGGWSYWSPWGPCSVSCGEGVNTRIRECNAPAPQ LGGKDCEG----ASRENRVCSQPHCPIDGEWGPYSPYSLCSATCGEGTKERTRTCDNPAP MYGGKYCSGKETDTVTCNDKPCPIHGKWSPWSKYGPCTASCGRGQKTRVRSCNNPAPEHG GEYCEGDSSEVRDCKGDPCPIDGGWGPYT------PFSRCSATCGGGFKKRTRE--CNNP APLFGGKYCVGDKTNIESCSEKTCPINNCLRNPC-------YPGVTCTPHDDG--SYECG TCPEGMQGDGGQCEDIDE--------------------------CKLVPDACFHYEGKHR CQNYPGGYSCMPCPMGHKGDIPTGTGVEY--AIAHKQECVVSNPCTDG-TNPCSENAECI --------------FLD------------------------------PTITPPFMCKCHP GYSSFPECRGFVCLEDADLDGIPDVDSSCMKDGVNITLKGDNCLNLPNSGQENADGDEFG DACDRDADND-GIVNE-----RDNCPLIHNPTQHDSDR---DGFGDVCDNCPFVRNPGQI DTDNDGLGDECDPDIDGDEILNSDDNCPYVHNPNQRDTDKDGVGDACDNCPNVINKDQSD ADSDLVGDACDTDLDRDKDGVQD---------------DLDNCPFVPNSGQADHDKDRIG DECDNDDDNDGILDKDDNCRLIH---------------NPDQKDSDGNGRGDVCEEDFDG DNIK--------DFEDACMDN-ALITKTDFTHFDMVKLDPTGTAQID------PNWVIRN KGKEI--------------IQT----KNCDPGLAVGKDMFNGVDFEGTFYVNTGN----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQKTQSYWRA----------- ------YPRQANAEAGLQLKVVESTTGPGEYLRN--ALWHT--------GDTPGQVR--- ---------------------------TLWTDSMHQGWQDHSAY---------------R WTLNHRPETGEIRVTMYN---------GKKLLTDSG------------------------ ------------------------RIIDRTYAG------------GRMGM-------FIF S-------QEMVFYSDMKYKCSDSK---INYK---------------------------- ----- >CAE1249094.1 THBS2S [Sepia pharaonis] ------------------------------------------------------------ ----------------MIALIAPAD----------------------------------- ---------------------AQFRP-----LRKPEIGAAFM---RYNELSLVGEIQ--L QS---NRRRGRATL-LRAENLAM------NTKFDSYIDFQRAEVVINL---KTKDGREYA VRFLTG--VL---SENKNKKIIIRFTNLQS----NSNG------IQLFVNCMNAGRDNTE LPIRDV-------------------LMGNFSVQR------H------------------- -------------------------------------------------PAFKLYGQASL -----------KELLMMQG-CEDTENI--------APTRPSI----PKPSLPSWVGSIDP DRR--FPDIDIKR-------------------------------------------ETHS REVSQDPFYTVDQI---------------------------------------------- ----------------KTDRIHHS----------------TIDSVKPELP---------- ---------------NAI---------VELTIAIRDLQRDFQNQ--------IRETHLLK ETL--------------------------------KECQMCRGTPP--EPGNLR------ --RC--SSNPCFQGVRCI-------DTEEG-------FRCG-SCPPGFY---GDGKTCSA Y-----------LTCNDRPCYPGVQ----------------------------CSD---T SSGFICG----------------------------------------------------- ------------------------------------------------------------ -----------------PCPT-------------------------TLTGDGTVHGCHPT RV-------------------------TCDSSPC-------FPGVMCTDQRTG---FHCG SCPTGYTGNGTYCEDLDE--------------------------CQ-FSRPC---DRRAT CTNLSPGFTCTPCPQGYTSSPITGIGILS--AQQTRQICQDIDECRSN-NGGCVPHSRCI NTRGSFRCSECDPGYSGNQTVGCRRQIS--NCSNG-KECHKNARCIQRPESSTHECQCSI GYGG----DGYYCSKDQDLDGIPDNALPCGHR----KCRKDNCVSTPNSGQEDADGDGLG DACDPDADND-GIVNN-----PDNCPLVANPDQDDTED-KPDRKGDACDNCPTIPNPEQT DTDDDGMGDTCDPDADNDGIINAHDNCIRVKNADQRDTDGDGIGDACDNCPFVPNVKQLD SDADLTGDACDTNDDKDDDGVQD---------------TNDNCPHIANSDQLDTDGDTLG DICDNDDDNDGVLDVNDNCPLRM---------------NPRQEDEDGNGVGDICEIDKDG DGSE--------DFIDVCPHN-GNIYATDFRAYQTVILDPEGDSQID------PNWVILN QGAEI--------------VQT----MNSDPGIAISYTAFAGVDFSGTFYVNTEV----- -DDDYAGFIFSYQ----------------DSSHFYVVMWKKNTQTYWHS----------- ------TPFRAVAEPGIQLKLVNSSTGPGQYLRN--ALWHT--------GDTHDQVR--- ---------------------------LLWKDPRNEGWKERKAY---------------R WELIHRPYKGLIRILFFE---------ETELIADSG------------------------ ------------------------NIYDFTLKG------------GRLGV-------FCF S-------QEMVIWSDLVYRCNDYIPPGLLEE---EDY---------------GYGQ--- ----- >AAK55517.1 putative thrombospondin [Drosophila melanogaster] -----------------------------------------------------------M NWT---RVLLIGLTALALTFVEVAS----------------------------------- ---------------------LSLDP-----VASAELEQFIR---KGDVVISTRHIR--- -----PRRKLH----ISIEALFMIDFPMLKHKMSFFLDRKQQRVTLDI----SANGATES RNFEIP--NI--NETSTIRSLALQF---------SKNR------ITLHVDCKASTHHDID MNLAKLYTQMDDP------------VIKLFRERK-------------------------- ---------------------------------------------------YPLHFDGDM -----------EHSLQRAN-CQKGNHR--------RGNRRM---------LRNKITEREK NKK--RDVRGWYE-------------------------------------------PTIA REG--------------------------------------------------------- ----------------------------------------VVDHRHQEVPTDVERGDIPV LNGD-----CEDALARSL---------SDLLALVKLLREDVAHQ--------RQEIAYLR MLL--------------------------------ENCAGCKN------PLTTDNQLRIE P-DCR-SANPCYPGVECL-------DSAAG-------PRCG-HCPLGFI---GDGKSCKP -----------GVTCAHHMCYPGVQ----------------------------CHD---T VNGAQCD----------------------------------------------------- ------------------------------------------------------------ -----------------SCPA-------------------------GYEGDGRT--CSLR NP--------------------------CLDTPC-------PSGAQCLQVGYPP-YFHCI SCPMGHEVNGTSCRDMNE--------------------------CL-LYDPC---DELAT CTNLSPGFQCSPCPVGFDGTHAHGYFADYYSVDYRRQTCLDVDECRTG-FFRCPEHSTCI NEIGSYRC-QCHEGYVTNGTYSCLDRSSVFMCPDG-TVCDRNAVCL-RMDNIRHKCHCNV GWAG----NGLICGRDTDVDGWPDQAIGCPEL----HCQRDNCPKLPNSGQEDADLDGHG DGCDDDADGD-NVQNS-----QDNCWLAYNTEQLDSDG---DKVGDVCDNCVLKYNPRQL DTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKD RDMDFVGDACHRDIDGDDDGVPN---------------SLDNCPMVSNSDQLDTDGDGTG DECDDDMDGDGIPNYKDNCPLAK---------------NPKQDDFNRNGKGDSCEDDEDV DGVP--------NGMDNCPNN-SMIHHTDFRTLQTIPLDPKGLSQAD------PNWVVHA NGTEI--------------VQT----LNSDPGLAVGKDAFGGVDFDGTFYINDDT----- -DDDYAGFVFSYQ----------------SSYKYYVVQWKKGTQTYWEP----------- ------RPFTASAAPGIQIKLVNSTEGPGPMMRN--SLWHE--------GNTDGEAR--- ---------------------------LLWKDPKNIAWKERTSY---------------R WSLVHRPAIGLIRLQMHE---------GNRLIFDSG------------------------ ------------------------NVFDSTLKG------------GRLGV-------FCF S-------QRMIIWSNLQYKCNNRVKPLIYNDL--SDYLKTKVELQD------------- ----- >XP_397221.5 cartilage oligomeric matrix protein isoform X1 [Apis mellifera] -----------------------------------------------------------M RV-----IITLIITIFFLVYVVDSS----------------------------------- ---------------------ITRD---------EDLEKNLRERWNDDFVIVFSNIK--- -----SKKKQFQVM---VEVLLTIKYE--KSKMVLMLDRRAKRVILEN---IDEVGHRVA QYINMD--NLNVNSNFPSKNVIFLVHQSQ-----PGAR------MAVYIDCIYRGVIPLK KTFRELTNSEDNL------------LIEAFRERKSQ---VKVYPLARSMEALQEENCLST LTDTNTESQELRSIDDNNNFETPSFNSARVNLRNKQNHHVHRSKEHNHDETVDLFEDTDQ -----------IDLNSRQS-NHNRHSV--------RDRSNRY----KHENDRNKYLEFDQ DFS--SLMKRLQQ-------------------------------------------PEYF NEPIQEKFEVLSNL---------------------------------------------- ----------------NESDILNQ----------------PINIYHKRVP---RRGDIGI QSLDERVCLTDNQIVKTL---------NELIGATKKIWREIELN--------RLETHRVL LLI--------------------------------ENCAACREPPP--VPLTTT---TPA PPSCS-YKSPCFPGSECR-------DTPRG-------PQCG-ACPPDYT---GDGYRCVK I------------TCAHNPCFKGVR----------------------------CYD---Q SDRYSCG----------------------------------------------------- ------------------------------------------------------------ -----------------NCPI-------------------------GYIGNGKH--CELK NV--------------------------CEPNPC-------YSEVQCDLISEPP-FYRCG VCPNGFTGNGSVCVDINE--------------------------CE-IAQPC---SLGVQ CINLHPGFRCDPCPPGYTGTMIEGVGLEI--AMNRKQICQDINECENN-NGGCDPYMECI NMQGSYRCGACRAGFIGNQTVGCHPAHS--ICPDLITRCDVNAECV-CIDTNVYSCRCRV GWTG----DGLICGIDRDNDGIPDRNLHCRDR----HCRMDNCPLTPNSGQEDADRDGIG DACDPDADDD-GVLNS-----SDNCPFISNPGQEDNDSDGPDLVGDICDNCPRVRNPKQE DTDDDGIGDACDPDIDNDGIPNNQDNCQKIKNQNQNDMDEDGIGDACDNCPYGYNPNQLD QDGDGVGDDCDNDNDRDRDGVQD---------------DRDNCPDVANSGQNDDDHDGIG NECDNDMDNDGVPNSNDNCPYVY---------------NPDQRHTHNNFIGDACWHDYDN DTVK--------NIHDNCPNN-SLIWATDFRKYTTIALDPFGTAQED------PVWVIHN DGAEI--------------QQL----VNSDPGIAIGPDIFSGVDFEGTFFVDDDG----- -DDDFVGFVFSYQ----------------DNRRFYIVAWKKAHQPYWVP----------- ------TPFRAVGDPGIYLKLVDSDTGPGEILRN--SLWHN--------ENTINQVK--- ---------------------------ILWHDPKKIGWKERTSY---------------R WQLLHRPKIGLIRFRLYQ---------GKQLMADSG------------------------ ------------------------NVYDSTLKG------------GKLGV-------YCF S-------QEKITWSNLLYVCKETVPLSVWNDL--PSNLRKEINVDINNEIKSQYSQKSI YYDSH >XP_031556620.1 cartilage oligomeric matrix protein-like [Actinia tenebrosa] -----------------------------------------------------------M KKSGSIWYLQSLLVLLSMVLNTEAK---------IQDFDLIKSFELGKGQ-----ITGLG RIEGYPGEPEEAYRFDRGLARLHLGP-----EFVSDLAEASR---ESKSLTITSNLK--- -----LDRKSYGTL-LSIETEG---EG--NLVFSLLFSCFSSCRISLY----YPEGSLTS VTYFDKVPNI---SDGKWHKMVLHI---------QTNRMGK-HVVSLFMDCRSLGKKKIS AGLDQLFPLSNEKVKYAL------RFAQRGASNS------VYIPWKGSLQS--------- ---------------------------------------------------VLLIFGVRS -----------HSFANPVD-CLTKSTRQILSGLTNKNNRHKY-----QPTVKVVTTQRRQ TTS--KDATTVKSTPTKPQKDG-------------------------------TTKPQPS VRPITQKEKPTRNI---------------------------------------------- -----------------VDIITSGETRFGVADGSSPTTELVLTTSDEKLD---------- -----YLV----DMIRQLK-KEQFHRESALRKTIEMLRIDLNSQ--------SQEVRYVR SFL--------------------------------EHGGACKSGSL-------------- -----------------------------------------------IQ---QTGKRFDS I----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------GTILPGRK--TDRQ NPVAGGK---------------------CLQKPC-------FPFVECYETPDEGLGFRCG PCPPGFTGNGIRCEDVNE--------------------------CNLY--PC---SALTK CINLRPGYQCTPCPVGYLGNASMGLGVEM--ARKNKQVCEDINECANGRNGGCSIHSECI NTQGSYRCGPCKPGYDGDSTRECKRVLFCSNAPRA-NPCGKLAHCIPRNDGRNYECKCKP GYGG----DGVRCGKDSDMDGYPDRALGCKGP----KCAKDNCREIPNSGQEDVDGDGTG DACEYDADGDRKPSKD-----QDNCPSVPNEDQQDTDA---DGVGDACDNCQTVNNPDQE DTDKDGIGDACDVDIDGDGIINVLDNCPKVPNRDQKNTDGDPHGDACDNCKRGKNPDQAD KDGDGIGDVCDFDQDYDRDGVDD---------------RHDNCLRKPNAAQLDTDGDGLG DVCDSDDDNDGIPDYKDNCRLVR---------------NVDQKDSDNDGIGDACQGDYDN DGVP--------DAVDICPYN-HNITKTDFSSFFNVNFDPLSKIKDY------PQWKASK KGNEV--------------YLR----KNSNVGLFVATPKYEDIEFRGTMFVNTHQ----- -DDDIIGFAFGYQ----------------QYGHFFLLSWKRKEQMYWIV----------- ------NPFRATAKTWLTLKRVKSSSVPSHGIRN--ALWHT--------AETRRHTK--- ---------------------------VLWQKRLTRGWKPKTAY---------------R WELNYTPSNGYLRLQMWV---------GTQQLMDTG------------------------ ------------------------ILRDLEMRG------------GRLGF-------FSF S-------QGDIIWSDLQVRCVDGK----------------------------------- ----- >NP_001361951.1 Peptidase M12B domain-containing protein [Caenorhabditis elegans] -----------------------------------------------------------M PP------FYIVITFLLSTVFRISQ----SVHHHLNEEELKQVFGVSNKHDVPE-YSLIE ATRHPLKNGNLKMKFTAWNDTYHLNLRKNSRIVSPHIISVVRH--GDDDVTTYAGLRDYE QCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFLVLQTLPKRVH-------HLQKERHL VYKRSA--GLLTNAESKIREEITRLQEEQESFCDTSEQLDDPAMTHLHFNYTIPTSAQLD SSF--IFPNMDPI-TLEIGLFLDSKLFEHFEREYIQDAEQHLLEFSLALIN----N---- ---------------------------------------------------VHVLYQQDT LTPNLDIVIVRYEMWRTQP-SALSTGVH-------KNGQAQS--------LLDAFCRYQA HMN-----------------------------------------------------PGTD LTDMNHYDHGVLLT---------------------------------------------- ----------------GYDIYHTTTSVAGVA---------PVARMCDPLF---------- ------AC----SLVEGLHLGRSFVLAHEMGHNMGMVHDGVQNQ--------CNKGCCLM SAVNGAGK---------------------------TTWSDCSVRE---FNAFLLQLDESG RGNCLRDASPGLISTNHLS------DLRLPGQRFTADQQCSYFWGRDYKVEIPNGKAMDD I-------------CRILWCGNSGS---------------------------TISTAHPA LEGSWCGA----N----KWCHKGQC----------------------------------- ----------------------------THWTF--------------------------- --------------GLTPVPIDGEWSEWGGAEKGCPIQQCAVSGSITVQGQHRD--CVNP APNNGGKTCEGANIRGIVC--------GATSSNCLGFTREEFGNKICSSIKYDPHKPDQQ LTGEGFEHSTQPCR----V------------------------WCHLIGSELIR------ ----NKGQFPDGTPCGFDAYCVGGQCLAL--SCDNKALVEQPEDCPRIEGRSVHQWEEWS ---------------------------------------------------SWSECSVSC GLGG-REVRERKCSSGRKCQGVSEESRPCEGV-------LRDC-------EEFGEWKEWG SCSEKCAL---GVQKRFRPCLTDQCSSKHLQEERPCDNEGCWTNWDEWSSCSQSCGGGRR YRIRKCLDDKC----DGDDLEKESCNTQKCISQSWGDWLPCSV-----SCGIGFQIRERL CD----GELCATANKQARTCNQQQCPSAFSLSVWSEWGEWTTCSATCGEGLQSRERSCRR GSCTEDDASQTRRCVNGPCEHSYLTWSEWTTCETCSSFDSRKRIAKCDGTTENCQDKIDE ETCDIACLREKHSFGPISPRRPKLITSNDLRKAFGRPLLPIESIHSEKWSEWGPCSVTCG SGRRVRTRGCQEASCPEQHIQTEECNLNSCLELFIWSDWSSCSKSCGQDGIQTRQKLCLF NNAECSSYAESRRCKDLPSCSSISSGRTISENGFDAPRWSEWSS--WSACSCFSLTSTRR RFCQVVDPTVQGFCAGAILEQIPCAPGSCSPSAGGWSLWSEWSSCSKDCGDTGHQIRNRM CSEPIPSNRGAYCSGYSFDQRPCVMDNVCSDEKVDGGWTDWTAWSECTDYCRNGHRSRTR FCANPKPSQGGAQCTGSDFELNPCFDPARCHLRDGGWSTWSDWTPCSASCGFGVQTRDRS CSSPEPKGGQSCSGLAHQTSLCDLPACDHESDGEWSAWNEWSGCMGNCGIGTRTRVRACV SPPVSDGGQPCFGRSSEITECRQSPSTALCSSFITSSHLADGYFIDT------DQQQ--- ----- >tr|E7F1S4|E7F1S4_DANRE Thrombospondin 2b OS=Danio rerio OX=7955 GN=thbs2b PE=3 SV=1 ---------------------------------------------------------MIL RR------CFRLLALLLLFTSVKSQ---DAQLEDETIFDLFESSGITRK------TIGVK LFKG-LDSDAPAYRFIRFDQLPSVSS-----TALQQLLLQIQ---NNEGFILTATLR--- -----QDRTSRGTI-LALEGPG----E--RRQLEIVSDGRTNTLDLVY---WWADGSRNV ISFEEV--DL---SDSQWKNITLYV---------HGET------ATLYIGCGLIDSFILD EP---FYEHLSAT-GASM------FVAKGSTRES------H---FRGLLQN--------- ---------------------------------------------------VRFIFDTQL -----------EDILESRG-CDLGNPV--------EANKVS---------ESAEFVEVP- --------------------------------------------------------SSIA TNVIGQN----------------------------------------------------- -----------------TDVPATSSS------------ELMCERSCEELA---------- ------------NLFQEL---------KGLRVVVSNLIDGLQKV--------TEENTAMK EALNKMQSLSEQSMCWQDGRMFEDK-----EDWIVDSCTKCTCQE----GKVVCRQITCP PVAC---ANPSFIDGECCPVCL-PMDSEDGWSPWSEWTQCTVTCGSGTQ---QRGRSCDD TSNTCSGPSIQTRKCSLGKCDRRVRQDGGWSLWSPWSSCSVTCGEGLITRIRHCNAPVPQ RGGKDCEG----EGRETQSC---------------------------------------- ------------------------------------------------------------ --------------HTDPCPIDGGWGPWS------PWAACSATCGGGLKSRVRE--CNSP EPQHGGRKCLGDSIENEVCNRLECPIDGCLSNPC-------FSGVECNTASDG--SWECG PCPNGYRGNGTSCEDVNE--------------------------CNMVSDLCHKVGGLQQ CVNTDPGFHCLPCPPRYKGTQPYGMGVES--AKTNKQVCEPYNPCKDN-SHSCHKFAECI --------------FLS------------------------------HFTDPMYKCECRI GYAG----DGIICGEDFDLDGWPNQDLVCGANATY-HCKKDNCPTLPNSGQEDFDNDGQG DACDKDDDND-EIVDE-----RDNCPLMYNPRQYDYDK---DDVGDRCDNCPYEHNPAQT DTDNNGEGDACSVDMDGDEILNERDNCPLIYNTDQKDTDLDGVGDQCDNCPLVHNPQQTD SDNDLVGDQCDNNQDIDEDGHQN---------------NMDNCPYIPNANQADHDGDGKG DACDFDDDNDGIPDDRDNCRLVP---------------NKDQEDSDGDGRGEACENDFDN DNVP--------DIFDACPEN-SGISVTDFRKFQMVHLDPKGTTQID------PNWVVRN QGKEL--------------VQT----ANSDPGIAVGFDEFSAVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSRRFYVVMWKQITQTYWEE----------- ------KPSKAFGISGVSLKVVNSTTGTGEILRN--ALWHT--------GNTKHQVR--- ---------------------------TLWHDPKNIGWKDFTAY---------------R WHLIHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PVYDKTFAG------------GRLGL-------FVF S-------QEAVFFSDLKYECRDN------------------------------------ ----- >tr|F8W5Z7|F8W5Z7_DANRE Thrombospondin 2a OS=Danio rerio OX=7955 GN=thbs2a PE=3 SV=1 ---------------------------------------------------------MIL RS------NLCLWPLLLLCIRALPQ---DGLVEDESIFDLFKISGISRK------TIGAK LFKG-HDWDSPAYRFIRFDHIPAVST-----PALHQILKQVQ---NNEGFVFVATMR--- -----QDKGSRGTL-LGVEGPG----G--LRQLEIVSNGRANTLDLVY----MVKGSQNV VSFEDV--DL---SDSQWKNISLYV---------HGEN------AHLYVGCSLIDSVILD EP---FYELLRPE-GSQM------FVAKGSIREN------H---FRGLLQN--------- ---------------------------------------------------VQFLFDTPI -----------ENILRNKG-CEIAKPE--------EVNVVN---------ESTESVSVG- --------------------------------------------------------TSIS TNFIGEK----------------------------------------------------- -----------------EKI-ASD----------------VCERSCEELS---------- ------------NMVQEL---------KGLRIIVGNLIDGLQKV--------TEENTVMK EVLGNMKNIKDKRMCWQDGRLFEDK-----EDWVVDSCTKCTCQE----SKIVCHQITCP PVAC---ASPTFLDGECCPLCL-PKDSEDGWSPWSEWTECTVTCGTGTQ---QRGRSCDA TSNPCSGPSIQTRRCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNSPVPQ LGGKDCEG----SGRETQKC---------------------------------------- ------------------------------------------------------------ --------------EAKPCPIDGAWGPWS------PWAVCSVTCGGGTRTRTRV--CNSP RPQYGGKKCPGDSVDTNACNKQDCPVDGCLSNPC-------FGGVECTSSPDG--SWECG PCPLGFRGNGKVCEDVNE--------------------------CDMVPDLCYKVGDSQR CVNTDPGFHCLPCPPRYKGNQPFGMGVEA--AKLNKQVCEQENPCKEK-THNCHRSAECI --------------YLG------------------------------HFSEPMFKCECKI GYAG----DGLICGEDSDLDGWPNQNLVCGANQSY-HCKKDNCPKLPNSGQEDFDKDGQG DACDKDDDND-GIMDE-----TDNCPLLYNPRQFDYDK---DLVGDRCDNCPYEHNPAQI DTDGNGEGDACAVDIDGDEVLNENDNCPYMYNTDQKDTDMDGVGDQCDNCPLLHNPEQTD SDNDRVGDECDNNQDIDEDGHQN---------------SLDNCPYIPNANQADHDKDGKG DACDSDDDNDGVPDDKDNCRLVP---------------NKDQRDSDGDGRGDACKDDFDN DSIP--------DFMDVCPEN-DAISNTDFRKFQMVHLDPKGTAQID------PNWVVRH QGKEL--------------VQT----ANSDPGIAVGFDEFNAVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSGRFYVVMWKQITQTYWED----------- ------NPSKAIGISGVSLKVVNSTTGTGEHLRN--ALWHT--------GDTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PVYDQTFAG------------GRLGL-------FVF S-------QELVYFSDLKYECRDN------------------------------------ ----- >NP_035711.2 thrombospondin-2 precursor [Mus musculus] ------------------------------------------------------------ --------MLWALALLALGIGPRAS---AGDHVKDTSFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYIPPVNT-----DDLNRIVKLAR---RKEGFFLTAQLK--- -----QDRKSRGTL-LVLEGPG---TS--QRQFEIVSNGPGDTLDLNY----WVEGNQHT NFLEDV--GL---ADSQWKNVTVQV---------ASDT------YSLYVGCDLIDSVTLE EP---FYEQLEVD-RSRM------YVAKGASRES------H---FRGLLQN--------- ---------------------------------------------------VHLVFADSV -----------EDILSKKG-CQHSQGA--------EVNTIS---------EHTETLHLS- --------------------------------------------------------PHIT TDLVVQG----------------------------------------------------- -----------------VEK-AQE----------------VCTHSCEELS---------- ------------NMMNEL---------SGLHVMVNQLSKNLERV--------SSDNQFLL ELIGGPLKTRNMSACVQEGRIFAEN-----ETWVVDSCTTCTCKK----FKTVCHQITCS PATC---ANPSFVEGECCPSCSHSADSDEGWSPWAEWTECSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGKNCKG----SGRETKPC---------------------------------------- ------------------------------------------------------------ --------------QRDPCPIDGRWSPWS------PWSACTVTCAGGIRERSRV--CNSP EPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPC-------FPGAKCNSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDICFSTNKAPR CVNTNPGFHCLPCPPRYKGNQPFGVGLED--ARTEKQVCEPENPCKDK-THSCHKNAECI --------------YLG------------------------------HFSDPMYKCECQI GYAG----DGLICGEDSDLDGWPNNNLVCATNATY-HCIKDNCPKLPNSGQEDFDKDGIG DACDEDDDND-GVSDE-----KDNCQLLFNPRQLDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQID QDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNSNQADHDNDGKG DACDSDDDNDGVPDDRDNCRLVF---------------NPDQEDSDGDGRGDICKDDFDN DNVP--------DIDDVCPEN-NAITETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------KPSRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGYMRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDA------------------------------------ ----- >NP_001162609.1 thrombospondin-2 precursor [Rattus norvegicus] ------------------------------------------------------------ --------MLWALALLALGIGPRAY---AGDHGEDTAFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYVPPVNT-----DDLNRIVKLAR---RKEGFFLTAQLK--- -----QDRKSRGTL-LVLEGPG---TS--QRQFEIVSNGPGDTLDLNY----WVEGHQHT NFLEDV--GL---ADSQWKNVTVQV---------ASDT------YSLYVGCDLIDSVTLE EP---FYEQLEAD-KSRM------YVAKGASRES------H---FRGLLQN--------- ---------------------------------------------------VHLVFADSV -----------EDILSKKG-CQHSQGA--------EVNTIS---------EHTETLHLS- --------------------------------------------------------PHIT TDLVVQG----------------------------------------------------- -----------------VEK-AQE----------------VCTHSCEELS---------- ------------NMMNEL---------SGLHVMVNQLSKNLERV--------SSDNQFLL ELIGGPLKTRNMSACVQEGRIFAEN-----ETWVVDSCTTCTCKK----FKTVCNQITCS PATC---ANPSLVEGECCPSCSHSADNDEGWSPWAEWTECSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QRAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKDCVGDVTEHQMCNKRSCPIDGCLSNPC-------FPGAKCNSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVADICFSINKASR CVNTNPGFHCLPCPPRYKGTQPFGIGLED--AKTEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNSNLVCATNATY-HCVKDNCPKLPNSGQEDFDKDGIG DACDEDDDND-GVSDE-----KDNCPLLFNPRQLDYDK---DEVGDRCDNCPYVHNQAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQMD QDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNSNQADHDNDGKG DACDSDDDNDGVPDDRDNCRLVF---------------NPDQEDSDGDGRGDICKDDFDN DNVP--------DIDDVCPEN-NAITETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------KPSRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGYMRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDA------------------------------------ ----- >NP_789861.1 thrombospondin-2 precursor [Bos taurus] ------------------------------------------------------------ --------MLWPLLLLALWAWPSAQ---AGDQDEDTAFDLFSISNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVSA-----EHLGRITEAMR---RKEGFFLTASMK--- -----QDRRSRGTL-LALEGPG---AT--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFALD EP---FYEHLQTE-RSRM------YVTKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQSQGA--------ETNAIS---------ENTETLHLS- --------------------------------------------------------PMVT MEHVGPS----------------------------------------------------- -----------------AEK-SPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVNQLHENLRKV--------SNDNQFLW ELIGGPPKTRNVSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGRCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRSCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGGAKEQQMCNRKSCPIDGCLSNPC-------FPGAECSSFPDG--SWSCG SCPGGFLGNGTHCEDLDE--------------------------CAVVTDVCFATSKAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCVKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVSDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPHIPNANQADHDRDGQG DACDSDDDNDGIPDDRDNCRLVA---------------NPDQEDSDGDRRGDACKDDFDN DSIP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_015139537.2 thrombospondin-2 isoform X1 [Gallus gallus] MCDGGRAPRSA----------------PQRR------QRPGSRQSPLVPSALLMPGVMLQ RS-----RLLWLAVFITLWVSSDAQ---D-DAKEENTFDLLQISNINRK------TIGAK LFRG-PDPAIPAYRFIRFDHIPPFKP-----EKLKKIVKLIR---QNEGFILSATLR--- -----QDRQSRGTI-LALEGPG---IS--ERQFEIISNGRANTLDLIY----WVDGFQNV ISLEDV--DL---ADSQWKNLTVQV---------TGEN------YNLYVGCDLIDSFILE EP---FYEQLKAE-NSRM------YVAKGSIREN------H---FRGLLQN--------- ---------------------------------------------------IHLIFDTSI -----------EDVLRKKG-CQRSQST--------EVNTIN---------ESTEILHLS- --------------------------------------------------------PAVT TEYVGEK----------------------------------------------------- -----------------TEK-KAE----------------FCDRSCEELG---------- ------------TMFTEL---------TGLRIVVNNLADNLQKV--------SEENQIMW ELIGPNKTLKNQSVCWQDGRVFADS-----ESWIVDSCTKCTCQD----SKIVCHQITCP PVSC---ADPSFIEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQ---MRGRSCDV TRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPIPQ MGGKNCVG----NGRETEKC---------------------------------------- ------------------------------------------------------------ --------------EKAPCPVNGQWGPWS------PWSACTVTCGGGIRERSRL--CNSP EPQYGGKPCVGDTKQHDMCNKRDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG PCPAGFLGNGTVCEDLDE--------------------------CIAVSDVCFKVNQVHR CVNTNPGFHCLPCPPRYKGSQPYGVGLEV--AKTEKQVCEPENPCKDK-THSCHKSAECI --------------YLG------------------------------HFSDPMYKCECRT GYAG----DGRICGEDSDLDGWPNNNLVCAANATY-HCVKDNCPLLPNSGQEDFDKDGKG DACDEDDDND-GVEDD-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTD ADNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYIPNANQADHDKDGKG DACDPDDDNDGIPDDRDNCRLRY---------------NPEQEDSDGDGRGDICKDDFDD DNVP--------DIFDVCPEN-NAISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGYDEFSSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGLIKVLVYE---------GKQVMVDSG------------------------ ------------------------PIYDTTFAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDA------------------------------------ ----- >XP_024213293.1 thrombospondin-2 [Pan troglodytes] ------------------------------------------------------------ --------MVWRLVLLALWVWPSTQ---AGHQDKDTTFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYIPPVNA-----DDLSKITKIMR---QKEGFFLTAQLK--- -----QDGKSRGTL-LALEGPG---LS--QRQFEIVSNGPADTLDLTY----WIDGTRHV VSLEDV--GL---ADSQWKNVTVQV---------AGET------YSLHVGCDLIDSFALD EP---FYEHLQAE-KSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSL -----------EDILSKKG-CQQGQGA--------EINAIS---------ENTETLRLG- --------------------------------------------------------PHVT TEYVGPS----------------------------------------------------- -----------------SER-RPE----------------VCERSCEELG---------- ------------NMVQEL---------SGLHVLVNQLSENLKRV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTSCTCKK----FKTICHQITCP PATC---ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CALVPDICFSTSKVPR CVNTQPGFHCLPCPPRYRGNQPVGVGLDA--AKTEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNLNLVCATNATY-HCIKDNCPHLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQADYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNANQADHDRDGQG DACDPDDDNDGVPDDRDNCRLVF---------------NPDQEDLDGDGRGDICKDDFDN DNIP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_043312836.1 thrombospondin-2 [Cervus canadensis] ------------------------------------------------------------ --------MLRPLLLLALWAWSSAQ---AGDQDEDTAFDLFSISNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVSA-----EHLGRIAEAMR---RREGFFLTASLK--- -----QDRRSRGTL-LALEGPG---AA--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFALD EP---FYEHLQTE-RSRM------YVAKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQNQGA--------EANAIS---------EDTETLHLS- --------------------------------------------------------PMVT MEHVGRS----------------------------------------------------- -----------------AER-GPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVSQLHENLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG ACPMGFLGNGTHCEDLDE--------------------------CAVVTDVCFATSKAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYISNANQADHDHDGQG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >KAF4024738.1 hypothetical protein G4228_016622 [Cervus hanglu yarkandensis] ------------------------------------------------------------ --------MLRPLLLLALWAWSSAQ---AGDQDEDTAFDLFSISNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVSA-----EHLGRIAEAMR---RREGFFLTASLK--- -----QDRRSRGTL-LALEGPG---AA--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFTLD EP---FYEHLQTE-RSRM------YVAKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQNQGA--------EANAIS---------EDTETLHLS- --------------------------------------------------------PMVT MDHVGRS----------------------------------------------------- -----------------AER-GPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVSQLHENLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG ACPVGFLGNGTHCEDLDEVGALPRLRGGPRRPGPGLMSSLLVPQCAVVTDVCFATSKAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYISNANQADHDHDGQG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRGECENRGHWGRVSQGTGKECTFCFS---FYKSCTSGK- ----- >XP_018118557.1 thrombospondin-2 [Xenopus laevis] ----------------------------------------------------------ML QR-----KLLLLHILISFGVSIYGQ---DEEKEDETNFDLFEISNINKR------TIGAK IFRG-HESSSPAFRFLRFDHIPPVNS-----EKVKQITELMQ---QNEGFILTATMR--- -----QDKHNRGTL-IAIEGPG---IS--NRLFELVSNGRANTLDLIY----WVDGSQNV ISLEDV--DL---ADSQWKNITVQL---------LGEN------FNLYIGCDLIDSFQLE ET---FYEHLKAD-NVKM------FLAKGSIRGN------H---FRGLLQD--------- ---------------------------------------------------VRLIFDISI -----------EDVLRKKG-CQLSHTG--------EVNTIS---------EKTEILHLS- --------------------------------------------------------P-MT TEYVGQK----------------------------------------------------- -----------------IEK-QID----------------FCDHSCDELG---------- ------------SMFTEL---------TRLRILVNNLLDNLQKV--------SEENQVLW ELIGPNKTLKNQSMCWQDGRVFADN-----EDWIVDSCTKCTCQN----SKTVCHQITCP PVHC---ASPSFIDGECCPMCF-PMDSEAGWSPWSEWTECSVTCGSGTQ---QRGRSCDA TSSSCEGSSIQTRTCHPGKCDNRIRQDGGWSHWSPWSACSVTCGIGNITRIRLCNSPKPQ LGGKNCTG----AGRETKQC---------------------------------------- ------------------------------------------------------------ --------------EGIPCPINGKWGPWS------PWSSCTVTCGGGLRERSRL--CNNP KPQYGGKKCGGEPKEKEMCNKQDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG ACPVGFVGNGTFCEDLDE--------------------------CALVSDACFQLGGLHR CVNTDPGYHCLPCPPRYKGTQPFGVGIEV--AKKDKQECEPINPCKDK-SHNCHKYAECI --------------YIG------------------------------HFSDPSYKCECRT GYAG----DGIICGEDSDLDGWPNNNLICAANATY-HCIKDNCPLLPNSGQEDFDKDGVG DACDKDDDND-GVDDE-----KDNCPLLYNPRQFDYDK---DEVGDRCDNCVYVHNPAQI DTDNNGEGDACAADIDGDDILNELDNCPYVYNTNQKDTDMDGVGDQCDNCPLMHNPDQTD VDNDLVGDQCDNNEDIDEDGYQN---------------NLDNCPYIPNANQADHDKDGRG DACDSDDDNDGVPDERDNCRLVY---------------NPDQKDSDGDGRGDACKDDFDN DSIP--------DIFDVCPEN-SDISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFSAVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPSRAYGYSGVSVKVVNSTTGTGEHLRN--ALWHT--------GNTPGEVR--- ---------------------------TLWHDPKNVGWKDYTAY---------------R WHLTHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PLYDKTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECKDF------------------------------------ ----- >OWK09861.1 THBS1 [Cervus elaphus hippelaphus] MPTL-----------------------PA--------WQPLTLGSP--P----RAAGSLL GADSSAMGLAWGLAVLLLSHVCGSSRI-PESGGDNSVFDIFELTGAARK------GSGRR LVKG-PDPSSPAFRIEDANLIPPVPD-----KKFQDLVDAVR---AEKGFLLLASLR--- -----QMKKTRGTL-LAVERKD---HS--GQLFSVVSNGKAGTLDLSL----TVQGKQHV VSVEEA--LL---ATGQWKGITLFV---------QEDR------AQLYIDCEKMENAELD VPIQSIFTRDLAS-IARL------RIAKGGVNDN----------FQGVLQN--------- ---------------------------------------------------VRFVFGTTP -----------EDILRNKG-CSSSTSV-FLTL---DNNVVN---------GSS------- --------------------------------------------------------PAIR TDYIGHK----------------------------------------------------- -----------------TKD-LQA----------------ICGISCDELS---------- ------------SMVLEL---------RGLRTIVTTLQDSIRKVVSGLRPPPTEENKELA NEL------RRPPLCYHNGVQYRTG-----DEWTVDSCTECRCQN----SVTICKKVSCP IMPC---SNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSVTCGNGIQ---QRGRSCDS LNNRCEGSSVQTRTCHIHECDKRCV----------------------ITRIRLCNSPSPQ MNGKPCEG----KARETKAC---------------------------------------- ------------------------------------------------------------ --------------QKDACPINGGWGPWS------PWDICSVTCGGGVQKRSRL--CNNP TPQFGGKDCIGDVTENQICNKQDCPIDGCLSNPC-------FAGVQCTSYPDG--SWKCG ACPPGYSGDGVACKDVDE--------------------------CKEVPDACFNHNGEHR CENTDPGYNCLPCPPRFTGSQPFGRGVEH--ATANKQVCKPRNPCTDG-THDCNKNAKCN --------------YLG------------------------------HYSDPMYRCECKP GYAG----NGIICGEDTDLDGWPNEDLVCVANATY-HCKKDNCPNLPNSGQEDYDKDGIG DACDDDDDND-KIPDD-----RDNCPFHYNPAQYDYDR---DDVGDRCDNCPYNHNPDQA DTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQKDTDMDGVGDQCDNCPLEHNPDQLD SDSDRIGDTCDNNQDIDEDGHQN---------------NLDNCPYVPNANQADHEKDGKG DACDHDDDNDGIPDDRDNCRLVP---------------NPDQKDSDGDGRGDACKDDFDQ DKVP--------DIDDICPEN-VDISETDFRRFQMIPLDPKGTSQND------PNWVVRH QGKEL--------------VQT----VNCDPGLAVGYDEFNAVDFSGTFFINTER----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQSYWDT----------- ------NPTRAQGYSGLSVKVVNSTTGPGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRHIGWKDFTAY---------------R WRLSHRPKTGFIRVVMYE---------GKKIMADSG------------------------ ------------------------PIYDKTYAG------------GRLGL-------FVF S-------QEMVFFSDLKYECRGRSKMTVNIQV--ESLVQTSIR-------NASHARG-- ----- >NP_001184085.1 thrombospondin-2 precursor [Canis lupus familiaris] ------------------------------------------------------------ --------MLGALVLLALWASSSAQ---AGDQDEDMAFDLFRISNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVSA-----DYLSRIAKIVR---QKEGFFLTASLK--- -----QDPKSRGTL-LALEGPG----A--QRQFEIVSNGPADTLDLTY----WIDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGDT------YSLYVGCDLIDSFTLD EP---FYEQLRTE-KTRM------YVAKGSARDS------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSV -----------EDVLSKKG-CQQSQGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PQGG PEYGGPG----------------------------------------------------- -----------------AQQ-RPE----------------VCERSCEELS---------- ------------TMITEL---------SGLHVIVNQLHENLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQITCP PATC---ANPSFVEGECCPSCFHSLDGEEGWSPWAEWTECSTTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDNRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKGC---------------------------------------- ------------------------------------------------------------ --------------QGVPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEQQMCNKRSCPIDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFTTSKAHR CVNTNPGFHCLPCPPRYKGSQPFGVGLEA--ARTEKQVCEPENPCKDK-THACHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGTG DACDDDDDND-GVDDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYISNANQADHDHDGQG DACDSDDDNDGVPDDRDNCRLVF---------------NPGQEDSDGDGRGDACKDDFDN DSIP--------DIDDVCPEN-SAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_013847876.1 thrombospondin-2 isoform X1 [Sus scrofa] MGRRQGGS---------------------------------------------FAGFSLE GS-----RMLWPLLLLASGAWSSAR---AGDQDEDTAFDLFSVSNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVGA-----EPLGRIAEAMR---RKEGFFLTASLK--- -----QDRKSRGTL-LALEGPG---AT--RRQFEIVSNGPADTLDLTY----WVDGAQHV ISLEDV--GL---ADAQWKNVTVQV---------TGET------YSLYVGCDLMDSFTLD EP---FYEQLKTE-QSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VFLVFENSV -----------EDLLSKKG-CRQSQGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PPVS TGHVGLG----------------------------------------------------- -----------------AEK-GRE----------------VCEHSCEELG---------- ------------SMIQEL---------SGLHVIVSQLHENLRKV--------SNDNQFLW ELIGGPPKTRNVSACWQDGRFFAEN-----ETWVVDSCTKCTCRK----FKTVCHQITCP PATC---ADPAFVDGECCPSCFS--DGEEGWSPWAEWTECSATCGPGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGRGCKG----SGRETRAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEQQMCNKRSCPVDGCLSNPC-------FPGASCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFTTSKAHR CVNTDPGFHCLPCPPRYKGSQPFGVGLEA--ARTEKQVCEPENPCEDK-THNCHRHAECV --------------YLG------------------------------HFSDPMFKCECRT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGTG DACDDDDDND-GVSDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDSNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDVDEDGHQN---------------NQDNCPYISNANQADHDHDGKG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSIP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_017195335.1 PREDICTED: LOW QUALITY PROTEIN: thrombospondin-2 [Oryctolagus cuniculus] ------------------------------------------------------------ --------MLWGLALLALWAWQGAQDVRAADPDEDTSFDLFSISNINRK------TIGAK QFRG-PEPGAPAYRFVRFDYIPPVNA-----ADLLRITRSMR---RRDGFFLTAQLK--- -----QDRKSRGTL-LALEGPG---AA---RQFEVVSNGPADTLDLTY----WTDGGQHV LSLEDV--GL---ADSQWKNITVQV---------AGET------FGLYVGCDLIDSFALD EP---FYEQLTAD-RSRM------YVAXGAARES------H---FRGLLQN--------- ---------------------------------------------------MHLVFENSV -----------EDVLSKKG-CQHGRGA--------EINAIS---------EHTETLHLS- --------------------------------------------------------PHLS AEHTGQS----------------------------------------------------- -----------------LQP-RPE----------------VCEHSCAELG---------- ------------NMISEL---------SGLHLLVDQLSENLRRV--------SSDNQFLL ELIGVPPKTRNVSGCWQEDRMFAEN-----ETWVVDSCTTCTCKK----FKTVCHQITCS PATC---ANPSIVEGECCPSCSHA-DGEEGWSPWAEWTECSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDARVRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKSCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------EGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKACVGDVKERQMCNRRSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG ACPVGYLGNGTYCEDLDE--------------------------CAVVTDVCFSTSKTAR CINTQPGFHCLPCPPRYKGSQPSGVGLEA--ARAEKQVCEPENPCKDK-THSCHKQAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNSNLVCATNATY-HCLKDNCPHLPNSGQEDFDKDGVG DACDDDDDND-GVSDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYVANANQADHDNDGKG DACDPDDDNDGIPDDRDNCRLLF---------------NPDQEDSDGDGRGDICKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPSRAYGYSGVSLKVVNSTTGAGEHLRN--ALWHT--------GNTQGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDHTYSG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_024104045.1 thrombospondin-2 [Pongo abelii] ------------------------------------------------------------ --------MVWRLVLLALWVWPSME---AGHQDKDTTFDLFSISNINRK------TIGAK QFRG-PDPGMPAYRFVRFDYIPPVNA-----DDLSKITKIMR---QKEGFFLTAQLK--- -----QDGKSRGTL-LALEGPG---LS--QRQFEIVSNGPADTLDLTY----WIDGTRHM VSLEDV--GL---ADSQWKNVTVQV---------AGET------YSLHVGCDLIDSFALD EP---FYEHLQAE-KSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSV -----------EDILSKKG-CQQGQGA--------EINTIS---------ENTETLRLG- --------------------------------------------------------PHVT TEYVGPS----------------------------------------------------- -----------------SER-RPE----------------VCERSCEELG---------- ------------NMVQEL---------SGLHVLVNQLSENLKRV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTTCTCKK----FKTICHQITCP PATC---ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTECSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ LGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKTCVGDVQERQMCNKRSCPVDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CALVPDICFSTSKVPR CVNTQPGFHCLPCPPRYRGSQPVGVGLEA--AKMEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNLNLVCATNATY-HCIKDNCPHLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQADYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDMDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNANQADHDRDGQG DACDPDDDNDGVPDDRDNCRLVF---------------NPDQEDLDGDGRGDICKDDFDN DNVP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_003204105.2 thrombospondin-2 [Meleagris gallopavo] -----------------------------------------------------MPGVMLQ RS-----RLLWLAVLITLWVSSDAQ---DDAKEEENTFDLLQISNINRK------TIGAK LFRG-PDPAIPAYRFIRFDHIPPFKP-----EKLKKIVKLIR---QNEGFILSAILR--- -----QDRQSRGTI-LALEGPG---IS--ERQFEIISNGRANTLDLIY----WVDGFQNV ISLEDV--DL---ADSQWKNLTVQV---------AGEN------YNLYVGCDLIDSFILE EP---FYEQLKAE-NSRM------YVAKGSIREN------H---FRGLLQN--------- ---------------------------------------------------IHLIFDTSI -----------EDVLRKKG-CQRSQST--------EVNTIN---------ESTEILHLS- --------------------------------------------------------PAVT TEYVGEK----------------------------------------------------- -----------------TEK-KAE----------------FCDRSCEELG---------- ------------TMFTEL---------TGLRIVVNNLADNLQKV--------SEENQIMW ELIGPNKTLKNQSVCWQDGRVFADS-----ESWIVDSCTKCTCQD----SKIVCHQITCP PVSC---ADPSFIEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQ---MRGRSCDV TRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPIPQ MGGKNCVG----NGRETEKC---------------------------------------- ------------------------------------------------------------ --------------EKAPCPVNGQWGPWS------PWSACTVTCGGGLRERSRL--CNSP EPQYGGKPCVGDTKQHDMCNKRDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG PCPAGFLGNGTVCEDLDE--------------------------CIAVSDVCFKVNQVHR CVNTNPGFHCLPCPPRYKGSQPYGVGLEV--AKTEKQVCEPENPCKDK-THSCHKSAECI --------------YLG------------------------------HFSDPMYKCECRT GYAG----DGHICGEDSDLDGWPNNNLVCAANATY-HCVKDNCPLLPNSGQEDFDKDGKG DACDEDDDND-GVEDD-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTD ADNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYIPNANQADHDKDGKG DACDPDDDNDGIPDDRDNCRLRY---------------NPEQEDSDGDGRGDICKDDFDN DNVP--------DIFDVCPEN-NAISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGYDEFSSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGLIKVLVYE---------GKQVMVDSG------------------------ ------------------------PIYDTTFAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDA------------------------------------ ----- >XP_003820249.2 thrombospondin-2 [Pan paniscus] ------------------------------------------------------------ --------MVWRLVLLALWVWPSTQ---AGHQDKDTTFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYIPPVNA-----DDLSKITKIMR---QKEGFFLTAQLK--- -----QDGKSRGTL-LALEGPG---LS--QRQFEIVSNGPADTLDLTY----WIDGTRHV VSLEDV--GL---ADSQWKNVTVQV---------AGET------YSLHVGCDLIDSFALD EP---FYEHLQAE-KSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSV -----------EDILSKKG-CQQGQGA--------EINAIS---------ENTETLRLG- --------------------------------------------------------PHVT TEYVGPS----------------------------------------------------- -----------------SER-RPE----------------VCERSCEELG---------- ------------NMVQEL---------SGLHVLVNQLSENLKRV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTSCTCKK----FKTICHQITCP PATC---ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKACVGDVQERQMCNKRSCPVDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CALVPDICFSTSKMPR CVNTQPGFHCLPCPPRYRGNQPVGVGLDA--AKTEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNLNLVCATNATY-HCIKDNCPHLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQADYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNANQADHDRDGQG DACDPDDDNDGVPDDRDNCRLVF---------------NPDQEDLDGDGRGDICKDDFDN DNIP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSHFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_006932208.1 thrombospondin-2 isoform X1 [Felis catus] ------------------------------------------------------------ --------MLWDLVLLALWAASGAR---AGDQDEDTAFNLFSISNINRK------TIGAK QFRG-PDPNVPAYRFVRFDYIPPVSA-----DYLSKIAKIVR---QKEGFFLTASLK--- -----QDPKSRGTL-LALEGPG---AS--QRQFEIVSNGPADTLDLTY----WIDGAQHV ISLEDV--GL---ADSQWKNITVQV---------TGET------YSLYVGCDLIDSFTLD EP---FYEQLRTE-KSRM------YVAKGSARDN------H---FRGLLQN--------- ---------------------------------------------------IYLVFENSV -----------EDVLSKKG-CQQSQGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PQVA TEYAGPG----------------------------------------------------- -----------------AHR-RPE----------------VCERSCEELG---------- ------------TMITEL---------SGLHVIVNQLHENLRKV--------SNDNQVLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQITCP PATC---ANPSFVEGECCPSCFHSLDGEEGWSPWAEWTQCSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKGC---------------------------------------- ------------------------------------------------------------ --------------QGTPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVQERQMCNKRSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG ACPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFAVGKAQR CVNTNPGFHCLPCPPRYKGTQPFGVGLEA--ARTEKQVCEPENPCKDK-THACHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCSTNATY-HCIKDNCPLLPNSGQEDFDKDGTG DACDDDDDND-GVDDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD IDNDLVGDQCDNNDDIDDDGHQN---------------NQDNCPYIPNANQADHDHDGQG DACDSDDDNDGVPDDRDNCRLVS---------------NPGQEDSDGDGRGDACKDDFDN DSIP--------DIDDVCPEN-SAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWEE----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTQGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_027828484.1 thrombospondin-2 [Ovis aries] ------------------------------------------------------------ --------MLRPLLLLALWAWSSAQ---AGDQDEDTAFDLFSLSNINRK------TIGAK QFRG-PDPHTPAYRFVRFDYIPPVSA-----EHLGRIAEAMR---RKEGFFLTASLK--- -----QDRRSRGTL-LALEGPG---AA--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFALD EP---FYEHLQTE-RSRM------YVAKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQSQGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PMVT MEHVGPS----------------------------------------------------- -----------------AEK-GPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVNQLHESLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCRK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRGCKG----SGRETAAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEQQMCNRKSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFATSRAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDSNGEGDACSADIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDDNEDIDEDGHQN---------------NQDNCPYIPNANQADHDRDGRG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_018885551.1 thrombospondin-2 [Gorilla gorilla gorilla] ------------------------------------------------------------ --------MVWRLVLLALWVWPSTQ---AGHQDKDTTFDLFSISNINRK------TIGAK QFRG-PDPGVPAYRFVRFDYIPPVNA-----DDLSKITKIMQ---QKEGFFLTAQLK--- -----QDGKSRGTL-LALEGPG---LS--QRQFEIVSNGPADTLDLTY----WIDGTRHV VSLEDV--GL---ADSQWKNVTVQV---------AGET------YSLHVGCDLIDSFALD EP---FYEHLQAE-KSRM------YVAKGSARES------H---FRGLLQN--------- ---------------------------------------------------VHLVFENSV -----------EDILSKKG-CQQGQGA--------EINAIS---------ENTETLRLG- --------------------------------------------------------PHVT TEYVGPS----------------------------------------------------- -----------------SER-RPE----------------VCERSCEELG---------- ------------NMVQEL---------SGLHVLVNQLSENLKRV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTTCTCKK----FKTICHQITCP PATC---ASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGAPCPIDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQYGGKACVGDVQERQMCNKRSCPMDGCLSNPC-------FPGAQCSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CALVPDICFSTSKVPR CVNTQPGFHCLPCPPRYRGSEPVGVGLEA--AKTEKQVCEPENPCKDK-THNCHKHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNLNLVCATNATY-HCIKDNCPHLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQADYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYISNANQADHDRDGQG DACDPDDDNDGVPDDRDNCRLVF---------------NPDQEDLDGDGRGDICKDDFDN DNIP--------DIDDVCPEN-NAISETDFRNFQMVPLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPRNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDI------------------------------------ ----- >XP_011482880.1 thrombospondin-2 isoform X1 [Oryzias latipes] ---------------------------------------------------------MKL WR------HLFL--FLSVFHQAASQ---DEEQLDETSFDLFEISHITRK------TLGAK QFRG-QNLDAPAYRFIRFDFLPPVDP-----PILKQILEQIQ---NNEGFVFVASMR--- -----QDHTSRGTL-VALEGPG----G--RRQFEIISNGPANTLDLVY----WVDGSQNV VSFEDV--DL---SDSQWKNITLHI---------HGEN------ANLFVGCNLLDSFVLD EP---FYEHLRAE-GSRM------YVAKGSNREN------H---FRGLLQS--------- ---------------------------------------------------VRFIFDTPV -----------ESILQNRG-CEVIKQD--------DPNTVR---------ESTEVIDVR- --------------------------------------------------------PSIT TNIIGQK----------------------------------------------------- -----------------TDDLGSD----------------MCERSCEELS---------- ------------TMFHEL---------KGLRVVVSNLIDGLQKV--------TEENTVMK EALGRMKETKEKNMCWQDGRLFEDK-----EDWVVDSCTKCTCQE----SKIVCHQITCP PVAC---ASPSFVDGECCPVCM-PKDSEDGWSPWSEWTECTVTCGIGTQ---QRGRSCDA TSNPCSGPSIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQ LGGTDCEG----SGRETQNC---------------------------------------- ------------------------------------------------------------ --------------TATPCPIDGGWGPWS------PWASCSATCGGGIKSRTRE--CNSP QPQHGGKKCLGEASDSDSCNKKDCPIDGCLSNPC-------FGGVDCSSSPDG--SWECG PCPAGFRGNGTHCEDINE--------------------------CDMVSDVCYKVSGTQR CVNTNPGFHCLPCPKRYKGTQPFGMGVES--AKRNKQVCEPENPCKDK-THSCHKFAECI --------------YIS------------------------------HFSDPMYKCECRT GYAG----DGFICGEDSDLDGWPNQNLVCGANTTY-NCQKDNCPDLPNSGQEDFDRDGQG DACDKDDDND-GILDE-----RDNCALLYNPRQFDFDK---DEVGDRCDNCPYEHNPAQI DTDHNGEGDACAVDIDGDDIHNDNDNCPYVYNTDQKDTDMDGVGDQCDNCPLLHNPDQSD IDNDLVGDQCDNNQDIDEDGHQN---------------NLDNCPYVANANQADHDKDGKG DACDYDDDNDGVPDDKDNCRLTP---------------NADQVDSDGDGRGDACKDDFDN DSIP--------DILDVCPEN-NAISVTDFRKFQMVHLDPKGTTQID------PNWVVRH QGKEL--------------VQT----ANSDPGIAVGFDEFNAVDFSGTMYVNTDR----- -DDDYAGFVFGYQ----------------SSGRFYVVMWKQITQTYWEY----------- ------KPSKAFGISGVSLKVVNSTTGTGENLRN--ALWHT--------GNTQGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PIYDKTFAG------------GRLGL-------FVF S-------QELVFFSDLKYECRDKPEYRTVILKTTEPGWED----------NSKRAKEKT PLQ-- >XP_013224536.2 thrombospondin-2 [Columba livia] ---------------------------------------------------------MLQ RS-----GLLWLAVLITLWVSSNAQ---DGDKEEETTFDLLQISNINRK------TVGAK LFRG-PDPATPAYRFIRFDHIPPCKP-----EKLKKIVRLIR---QNEGFILSATLR--- -----QDRQSRGTI-LALEGPG---IS--ERQFEIISNGRANTLDLIY----WVDGFQNV ISLEDV--DL---ADSQWKNLTVQI---------TGEN------YNLYVGCDLIDSFILE EP---FYEQLKAE-NSRM------YVAKGSIREN------H---FRGLLQN--------- ---------------------------------------------------IQLIFDTSI -----------EDVLCKKG-CQRSQST--------EVNTIN---------ESTEILHLS- --------------------------------------------------------PAVT TEYVGEK----------------------------------------------------- -----------------PEK-KAE----------------FCDRSCEELG---------- ------------TMFTEL---------TGLRIVVNNLADNLQKV--------SEENQIMW ELIGPNKTLKNQSVCWQDGRVFADS-----ESWIVDSCTKCTCQG----SKIVCHQITCP AVSC---ANPSFVEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQ---MRGRSCDV TRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQ MGGKNCVG----NGRETEKC---------------------------------------- ------------------------------------------------------------ --------------EKVPCPVNGQWGPWS------PWSACTVTCGGGIRERSRL--CNSP EPQYGGKPCVGDIKQHDMCNKKDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG PCPAGYLGNGTICEDLDE--------------------------CIAVSDVCFKVNQVHR CVNTNPGFHCLPCPPRYKGSQPYGVGLEI--AKTEKQVCEPENPCKDK-THSCHKSAECI --------------YLG------------------------------HFSDPMYKCECRT GYAG----DGRICGEDSDLDGWPNNNLVCAANATY-HCMKDNCPLLPNSGQEDFDKDGKG DACDEDDDND-GVEDD-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTD ADNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYIPNANQADHDKDGKG DACDPDDDNDGVPDDRDNCRLRY---------------NPEQEDSDGDGRGDICKDDFDN DSVP--------DIYDVCPEN-NAISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGYDEFSSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPTRAYGYSGVSLKVVNSTTGAGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGLIKVLVYE---------GKQVMVDSG------------------------ ------------------------PIYDTTFAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDA------------------------------------ ----- >XP_017908975.1 PREDICTED: thrombospondin-2 [Capra hircus] ------------------------------------------------------------ --------MLRPLLLLALWAWSSAQ---AGDQDEDTAFDLFSLSNINRK------TIGAK QFRG-PDPRTPAYRFVRFDYIPPVSA-----EHLGRIAEAMR---RKEGFFLTASLK--- -----QDRRSRGTL-LALEGPG---AA--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFALD EP---FYEHLQTE-RSRM------YVAKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQSRGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PMVT MEHVGPS----------------------------------------------------- -----------------AEK-GPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVNQLHESLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRSCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDIKEQQMCNRKSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFATSRAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDDNEDIDEDGHQN---------------NQDNCPYIPNANQADHDRDGRG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_025050742.1 thrombospondin-2 isoform X1 [Alligator sinensis] MKRGVCARKLAKNNFSNYLAGLIEDITPTQRTLAAYVLRP-TRLQPTPP----ITRVMLL RS-----SLLWLTFLLTLWATSNAQ---DGDKEEETTFDLLQISNINRK------TIGAK VFRG-PNPTTPAYRFIRFDHIPPVNP-----EKLKQIIKLLR---KNEGFILSATLR--- -----QDRQSRGTI-IALEGPG---TT--QRQFEIISNGRANTLDLIY----WVDGSQNV ISLEDV--DL---ADSQWKNLTVQV---------TGET------YNLYVGCDLIDSFILE EP---FYEQLKAE-NSRM------YVTKGSIREN------H---FRGLLQN--------- ---------------------------------------------------VNLIFDISL -----------EEVLRKKG-CQRSQTI--------EVNTIN---------ESTEILHLS- --------------------------------------------------------PAVT TEYVGEK----------------------------------------------------- -----------------TEK-KAE----------------FCDRSCEELG---------- ------------TMFTEL---------TGLRVVVNNLVDNLQKV--------SEENQIMW ELIGPNKTLKNQSVCWQDGRVFADN-----EIWTVDSCTKCTCQN----SKIVCHQITCP AVSC---ANPSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQ---MRGRSCDV TRSSCTGPHIQTRMCSFKKCEHRIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQ MGGKNCEG----KGRETEKC---------------------------------------- ------------------------------------------------------------ --------------EKVPCPINGQWGPWS------PWSACTVSCGGGIHERSRL--CNSP EPQYGGKPCVGDVKQHDICNKKDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG ACPSGYLGNGTVCEDLDE--------------------------CIAVPDVCFKVNQAHR CVNTNPGFHCLPCPPRYKGTQPFGVGLEV--AKAEKQVCEPENPCKDK-THQCHKSAECI --------------YLG------------------------------HFSDPMYKCECRT GYAG----DGRICGEDSDLDGWPNKNLVCAANATY-HCMKDNCPLLPNSGQEDFDKDGKG DACDEDDDND-GVEDD-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTD TDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYIPNANQADHDKDGKG DACDSDDDNDGVPDDRDNCRLRF---------------NPDQEDSDGDGRGDICKDDFDN DSIP--------DIYDVCPEN-YDISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGYDEFSSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPTRAYGYSGVSLKVVNSTTGAGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGLIRVSVYE---------GKQVMVDSG------------------------ ------------------------PIYDMTFAG------------GRLGL-------FVF S-------QEMVYFSDLKYECKDF------------------------------------ ----- >XP_006277456.1 PREDICTED: thrombospondin-2 isoform X1 [Alligator mississippiensis] -----------------------------------------------------MPGVMLL RS-----SLLWLTFLLTLWATSNAQ---DGDKEEETTFDLLQISNINRK------TIGAK VFRG-PNPTTPAYRFIRFDHIPPVNP-----EKLKQIINLLR---KNEGFILSATLR--- -----QDRQSRGTI-IALEGPG---TT--QRQFEIISNGRANTLDLIY----WVDGSQNV ISLEDV--DL---ADSQWKNLTVQV---------TGEN------YNLYVGCDLIDSFILE EP---FYEQLKAE-NSRM------YVTKGSIREN------H---FRGLLQN--------- ---------------------------------------------------VNLIFDISL -----------EEVLRKKG-CQRSQTI--------EVNTIN---------ESTEILHLS- --------------------------------------------------------PAVT TEYIGEK----------------------------------------------------- -----------------TEK-KAE----------------FCDRSCEELG---------- ------------TMFTEL---------TGLRVVVNNLVDNLQKV--------SEENQIMW ELIGPNKTLKNQSVCWQDGRVFADN-----EIWTVDSCTKCTCQN----SKIVCHQITCP AVSC---ANPSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQ---MRGRSCDV TRSSCTGPHIQTRMCSFKKCEHRIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQ MGGKNCEG----KGRETEKC---------------------------------------- ------------------------------------------------------------ --------------ERVPCPINGQWGPWS------PWSACTVSCGGGIHERSRL--CNSP EPQYGGKPCVGDVKQHDICNKKDCPIDGCLSNPC-------FPGAECNSYPDG--SWSCG ACPSGYLGNGTVCEDLDE--------------------------CIAVPDVCFKVNQAHR CVNTNPGFHCLPCPPRYKGTQPFGVGLEV--AKAEKQVCEPENPCKDK-THQCHKSAECI --------------YLG------------------------------HFSDPMYKCECRT GYAG----DGRICGEDSDLDGWPNKNLVCAANATY-HCMKDNCPLLPNSGQEDFDKDGKG DACDEDDDND-GVEDD-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTD MDNDLVGDQCDNNEDIDDDGHQN---------------NQDNCPYIPNANQADHDKDGKG DACDSDDDNDGVPDDRDNCRLRF---------------NPDQEDSDGDGRGDICKDDFDN DSIP--------DIYDVCPEN-YDISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGYDEFSSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPTRAYGYSGVSLKVVNSTTGAGEHLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGLIRVSVYE---------GKQVMVDSG------------------------ ------------------------PIYDMTFAG------------GRLGL-------FVF S-------QEMVYFSDLKYECKDF------------------------------------ ----- >XP_015799926.1 PREDICTED: thrombospondin-2 isoform X1 [Nothobranchius furzeri] ---------------------------------------------------------MIL RS------SLFLL-LLSTFHQVAPQ---DGEQEDEMSFDLFEISHITRK------TLGAK QFRG-QNLDAPAYRFIRFDHLPPVST-----PILKQILRQIQ---NNEGFVFVASIR--- -----QDRGSRGTL-IGLDGPD----G--RRQFEIVSDGRANTLDLVY----WVDGSRNV FSFEDV--DL---SDSQWKNVTLHI---------HGEN------ANLFVGCSLIDSFILD EP---FYENLRAE-GSRM------FVAKGSTRES------H---FRGLLQN--------- ---------------------------------------------------VHFLFDTSM -----------EDILLSRD-CEVEKQD--------TDNIVS---------ESTEIVDVR- --------------------------------------------------------PSTT TNIIGQK----------------------------------------------------- -----------------TDDLGTD----------------MCERSCEELS---------- ------------TMFQEL---------KGLRVVVSNLIDGLQKV--------TEENTVMK EALGRMKDSKEKNMCWQDGRLFEDK-----EDWVVDSCTKCTCQE----SKIVCHQITCP PVAC---ASPSLIDGECCPVCM-PKDSEDGWSPWSEWTECTVTCGIGTQ---QRGRSCDA TSNPCSGPSIQTRKCSLGRCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQ LGGKDCAG----SGRETQKC---------------------------------------- ------------------------------------------------------------ --------------IAEPCPIDGAWGPWS------PWATCSATCGGGVKSRSRE--CNSP RPQYGGKKCIGEPNDSDSCNKEDCPIDGCLFNPC-------FGGVDCSSSPDG--SWECG PCPAGFRGNGTHCEDINE--------------------------CDMVSDVCYKVSGTQR CVNTDPGFHCLPCPKRYKGTQPYGMGIEA--AKRNKQVCEPENPCKEK-THSCHKYAECI --------------YIS------------------------------HFSDPMYKCECRT GYAG----DGFICGEDSDLDGWPNQNLVCDANATY-HCKKDNCPNLPNSGQEDFDKDGQG DACDKDDDND-GILDD-----RDNCPLLYNPRQFDFDK---DDVGDRCDNCPYEHNPAQI DTDHNGEGDACAVDIDGDEILNENDNCPYVYNTDQKDTDMDGVGDQCDNCPLLHNPDQTD VDNDLVGDQCDNNQDIDEDGYQN---------------NLDNCPYVANANQADHDKDGKG DACDYDDDNDGIPDEKDNCRLTP---------------NEDQLDSDGDGRGDACKDDFDN DNIP--------DILDVCPEN-NAISVTDFRKFQMVHLDPKGTTQID------PNWVVRH QGKEL--------------VQT----ANSDPGIAVGFDEFNAVDFSGTMYVNTDR----- -DDDYAGFVFGYQ----------------SSGRFYVVMWKQITQTYWED----------- ------KPSKAFGISGVSLKVVNSTTGTGENLRN--ALWHT--------GNTAGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PVYDKTFAG------------GRLGL-------FVF S-------QELVFFSDLKYECRDKPQFPEVFTR--------------------------- ----- >XP_020762367.1 thrombospondin-2 [Odocoileus virginianus texanus] ------------------------------------------------------------ --------MLRPLLLLALWAWSSIQ---AGDQDEDTAFDLFSISNINRK------TIGAK QFRG-PDPSVPAYRFVRFDYIPPVSA-----EHLGRIAEAMR---RREGFFLTASLK--- -----QDRRSRGTL-LALEGPG---AA--HRQFEIVSNGPADTLDLTY----WVDGTQHV ISLEDV--GL---ADSQWKNVTVQV---------TGET------YSLYVGCDLMDSFALD EP---FYEHLQTE-RSRM------YVAKGAARES------H---FRGLLQN--------- ---------------------------------------------------VYLVFENSV -----------EDLLSKKG-CQQNQGA--------EANAIS---------ENTETLHLS- --------------------------------------------------------PMVT MDHVGRS----------------------------------------------------- -----------------AER-GPE----------------VCEHSCEELG---------- ------------SMIREL---------SGLHVIVNQLHESLRKV--------SNDNQFLW ELIGGPPKTRNMSACWQDGRFFAEN-----ETWVVDSCTKCTCKK----FKTVCHQISCP PATC---ADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGPGTQ---QRGRSCDV TSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQ MGGRNCKG----SGRETKAC---------------------------------------- ------------------------------------------------------------ --------------QGPPCPVDGRWSPWS------PWSACTVTCAGGIRERTRV--CNSP EPQHGGKDCVGDVKEHQMCNRKSCPVDGCLSNPC-------FPGAECSSFPDG--SWSCG SCPVGFLGNGTHCEDLDE--------------------------CAVVTDVCFATSKAHR CVNTNPGYHCLPCPPRYKGNQPFGVGLEA--ARTEKQVCEPENPCKDK-THSCHRHAECI --------------YLG------------------------------HFSDPMYKCECQT GYAG----DGLICGEDSDLDGWPNKNLVCATNATY-HCIKDNCPLLPNSGQEDFDKDGIG DACDDDDDND-GVTDE-----KDNCQLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTD VDNDLVGDQCDNNEDIDEDGHQN---------------NQDNCPYISNANQADHDHDGQG DACDSDDDNDGVPDDRDNCRLVA---------------NPDQEDSDGDGRGDACKDDFDN DSVP--------DIDDVCPEN-NAISETDFRNFQMVHLDPKGTTQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFGSVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVVMWKQVTQTYWED----------- ------QPTRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTEGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLTHRPKTGYIRVLVHE---------GKQVMADSG------------------------ ------------------------PIYDQTYAG------------GRLGL-------FVF S-------QEMVYFSDLKYECRDV------------------------------------ ----- >XP_030298404.1 thrombospondin-2 isoform X1 [Sparus aurata] ---------------------------------------------------------MIL RR------SLFLLLLSFNFLHALPE---DGEQEDETSFDLFEISHITRK------TLGAK QFRG-QNSDAPAYRFIRFDHLPPVSP-----PILKQILRQIQ---NNEGFVFAASIR--- -----QDRASRGTL-IGLEGPD----G--QRQFEIVSNGRANSLDLVY----WVEDSQNV VSFEDV--DL---SDSQWKNITLHI---------HGEN------ANLFVGCSLIDSHILD EP---FYEHLQAE-GSRM------YVAKGSIREN------H---FRGLLQN--------- ---------------------------------------------------VRFVFDTPV -----------EDVLLSRD-CEVSKQD--------DANIVS---------ESTEVVDVS- --------------------------------------------------------PSIT TNIIGQK----------------------------------------------------- -----------------TDDVGAD----------------MCERSCEELS---------- ------------TMFQEL---------KGLRHVVSNLIDGLQKV--------TEENSVMK EALGRMKNTKEKNMCWQDGRLFDDK-----EDWVVDSCTKCTCQE----SKIVCHQITCP AVAC---ASPSFVDGECCPVCL---HSEDGWSLWSEWTECTVTCGTGTQ---QRGRSCDA TSNPCDGPSIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQ LGGKDCEG----SGRETQRC---------------------------------------- ------------------------------------------------------------ --------------TAQPCPIDGGWGPWS------PWATCSATCGGGIKTRMRE--CNSP QPQHGGRKCIGEANDEAGCNKKDCPIDGCLSNPC-------FGGVDCNSAPDG--SWECG PCPAGFRGNGTHCEDINE--------------------------CDMVSDVCYKVAGTQR CVNTDPGFHCLPCPKRYKGTQPFGMGVEA--AKKNKQVCEPENPCKDK-THNCHKYAECI --------------YIS------------------------------HFSDPMYKCECRT GYAG----DGFICGEDSDLDGWPNLNLVCGANATY-HCKKDNCPSLPNSGQEDFDKDGQG DACDKDDDND-GILDE-----RDNCPLLYNPRQFDFDK---DEVGDRCDNCPYEHNPAQI DTDNNGEGDACAVDIDGDEIMNENDNCPYVYNTEQKDTDMDGVGDQCDNCPLLHNPDQTD VDNDLVGDQCDNNQDIDEDGHQN---------------NLDNCPYVANANQADHDKDGKG DACDYDDDDDGVPDDKDNCRLTP---------------NADQLDSDGDGRGDACKDDFDN DSIP--------DILDVCPEN-NAISVTDFRKFQMVHLDPKGTTQID------PNWVVRH QGKEL--------------VQT----ANSDPGIAVGFDEFSAVDFSGTMYVNTDR----- -DDDYAGFVFGYQ----------------SSGRFYVVMWKQITQTYWED----------- ------KPSKAFGISGVSLKVVNSTTGTGENLRN--ALWHT--------GNTPGQVR--- ---------------------------TLWHDPKNIGWKDYTAY---------------R WHLIHRPKTGFIRVVVYE---------GKQIMADSG------------------------ ------------------------PVYDKTFAG------------GRLGL-------FVF S-------QELVFFSDLKYECRDKPEFPTVFTR--------------------------- ----- >XP_040206850.1 thrombospondin-2 [Rana temporaria] MRLV-------------------------------------------------TKRGVML QT-----TLQRLLIFLCFWAFLNAQ---DEDGEDETTFDLFEISNINKR------TIGVK MFRG-HDPNSPAYRFLRFDHIPPVKS-----EKMREIIHLMQ---LNEGFILTATIK--- -----QDKRNRGTL-LSIEGPG---IS--NRMFELVSNGRANTLDLIY----WIEGTQNV ISLEDV--DL---ADSQWKNITVQL---------TGEN------FNLYVGCDLMDSFRLE ET---FYEHLKAD-NNKM------FLARGSIREN------H---FRGLLQK--------- ---------------------------------------------------IKLIFDTPV -----------EDILKKKG-CQLGHTG--------D-NAIS---------EKTEMIHLS- --------------------------------------------------------P--L TEYVGKK----------------------------------------------------- -----------------EDR-QID----------------FCDRSCDELS---------- ------------TMFTEL---------SGLRVVVNNLLDNLQKV--------SEENQELW ELIGPNKTLKNQSVCWQDGRVFGDN-----EDWIVDSCTKCTCQS----SKTVCHQITCP TVHC---DSPTFVEGECCPVCF-PLDNEAGWSPWSEWTECSVTCGPGTQ---QRGRSCDA TSSTCAGSSIQTRTCNPGKCDHRIRQDGAWSHWSPWSACSVTCGIGNITRIRLCNSPKPQ LGGKNCTG----IGRETKEC---------------------------------------- ------------------------------------------------------------ --------------EGVPCPINGKWGPWS------PWSSCSVTCGGGLRERSRI--CNNP KPQYGGKKCGGDTKEKDMCNKQDCPIDGCLSNPC-------FPGSECNSYPDG--SWSCG ACPVGYIGNGTFCEDLDE--------------------------CTLVTDACFRLGGVHR CVNTDPGYQCLPCPPRYKGNQPFGVGLEV--AQKDKQVCEPINPCKDK-SHNCHKSAECI --------------YIG------------------------------HFSEPSFKCECRT GYAG----DGIICGEDSDLDGWPNNNLICAANATY-HCVKDNCPLLPNSGQEDFDKDGVG DACDRDDDND-GVDDE-----KDNCPLLFNPRQFDYDK---DEVGDRCDNCPYVHNPAQI DTDNNGEGDACAVDIDGDDILNELDNCPYVYNTDQTDTDKDGVGDQCDNCPLMHNPDQTD VDNDLVGDQCDNNEDIDEDGYQN---------------NLDNCPYIPNANQADHDKDGRG DACDSDDDNDGVPDDRDNCRLVF---------------NPDQKDSNGDGRGDECKDDFDN DSIP--------DIFDVCPEN-SGISETDFRKFQMVPLDPKGTAQID------PNWVIRH QGKEL--------------VQT----ANSDPGIAVGFDEFSAVDFSGTFYVNTDR----- -DDDYAGFVFGYQ----------------SSSRFYVLMWKQVTQTYWED----------- ------KPSRAYGYSGVSLKVVNSTTGTGEHLRN--ALWHT--------GNTPGEVR--- ---------------------------TLWHDPKNVGWKDYTAY---------------R WHLTHRPKTGYIRVVVYE---------GKLIMADSG------------------------ ------------------------PLYDKTYAG------------GRLGL-------FVF S-------QEMVFFSDLKYECKDF------------------------------------ -----
BMGE Cleaned alignment of selected proteins >sp|P35442|TSP2_HUMAN Thrombospondin-2 OS=Homo sapiens OX=9606 GN=THBS2 PE=1 SV=2 MVWRLVLLALWKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNDLSKITKEGFFLTAQLKQDGKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHVVSLEDVADSQWKNVTVQVYSLHVGCDLIDSFALDEPFYEHLQAEYVAKGSARESFRGLLQNVHLVFENSVEDILSKKGEINAISENTETLRLGVCERSCEELGNMVQELSGLHVLVNQLSNLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSPRCVNTQPGFHCLPCPPRYRGNQPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_038078580.1 thrombospondin-1-like isoform X1 [Patiria miniata] YVFAFGFLCSAAYEEVDVMLASGISARTPGVRETKTPE-GGRAFKVRPKDRDLGTDSLERLLDEGFILITVAYQDPKNRGTLVSVDRTDVRGFGFHIDRRNDEAVVQFAGEPQSQVVFSPLDDTELHTFVLDVVTLYMDCQLIGLKILPSSFYMNMEPDRLGKGLPDRNFKGTLAVAKFAFQTSTTDVLISQGSSSQISGESEPSHISQCAYTCEQISNLNNQVQVLSDGYDDMWKLEHFENQRP---------PEWPSQQGCWYMKTLYDDGDVFKVDKCKSCECRPTVECSLIKCQPGKCANPIIMEGDCCPTCP---NDNLGWSDWAEWTSCSVTCGNGIQQRGRSCDRTQFECNGNDVETRVCYLDPCIEIV--DGGWSNFTPW-SCGVTCGNGTESRMRSCNSPRPKNGGKRCDGAGREERPCGRDPCPVDGQWGQFSEFTPCTKTCDGGWQERYRFCDSPPPAHGGRDCVGSDTHRMCNEWPCPIDACLSSPCFDGVECVSFTDGRYECKDCPVGYTGNGILCQDINECLLVSDACFNFHHRCLNLIPGYTCRKCPIGYRGNQPSGMGVYHAKRYKQQCIPINPCAEGTSSCHIDARCIPYSDPQYGCKCKTGFAGDGVHCGYDSDLDGWPDEQLDCEDHGDYHCTRDNCASLPNSGQEDNDGDGKGDACDADDDDDLVDDVADNCQFISNWQQFDIDDDGVGDVCDNCPFVSNTRQEDTDSDGDGDVCDYDIDEDGIYNEDDNCMYVANARQLDFDEDGYGDVCDNCPDYGNPDQMDIDDDNVGDVCDTDRDVDNDGHQDDLDNCWNIANSDQADHDMDGIGDACDFDDDNDGIEDVDDNCRLIFNPSQNDTNENGRGDACEYDNDGDGVTDLQDACPDNANIQRTDLSHFQLIKLDPEGSAQIDPHWIVRNRGQELINSDPGLAIGYDEFNSVEFSGTFYVNTERDDDYAGFVFGYQSNHRFYSVMWKQVTQKYWEPMPTMSEATAGLQLKLINSTTGPGEYLRNALWHTGDTSDQVKLIWSDANKIGWKDFTAYRWILTHRPRTGYIRVTMYEGSKVLADSGALYDFTLQGGRIGLQEMVFFSDLQYKCLAE >XP_030855692.1 thrombospondin-1 [Strongylocentrotus purpuratus] FVLFIATLLPA-YVEFNVLQDVGISAASPGVDLVRGQEENSVAYKIKPNKGDMAANDVQRLGEDGFVLVAKVKMGQKARGTVVSLDGHGDRLFGLVIDRKSDSVLMPYDGVTTDSLEFSGLEDRDWHTFTLDIAILYADCTRVGLQIMYGSFVYDVTPDRLGKGLKGRKFKGIIEDVKFIFGQRGTRILRLQG------SQSSSSDISQCAITCDQISQLRNMVDVLSQGQENILRVTDMDNRIP-------------SQTPPWLDGCFYKNEEEWKDDACTTCECNPAVTCRLIECQPITCQNPIIKPGECCPQCP---NEEQGWSDWTEWTSCSVTCGSGTMQRGRSCDRMRYPCNGRSVETRNCIRDSCVSVV--DGGWSNWTPW-ACGITCGVGTETRVRSCNSPPPQNGGARCLGAGREERLCQRDPCPVDGAWGEWSLWTACTHSCDGGNQERYRFCDSPTPAHGGRNCSGIKRQEMCNQRPCPIDGCLSSPCFEGVDCRSSDDGVFQCGPCPVGFRGDGQSCTDVNECLEVLNTCFHHHHRCINKIPGYSCQECPTGYRGNQPNGIGIFHASRYRQQCIPINPCTEGTHDCAPDAKCTPYSQPQYGCRCRTGYAGDGYACGLDSDLDGRPDVDLDCQGLGDYHCHKDNCPRLPNSGQEDSDRDGEGDACDDDDDDDGIRDDRDNCQFTPNRWQGDRDRDKVGDECDNCPTHSNPRQENVDGDEFGDECDDDIDNDGHDNFIDNCPKHANANQDDSDHDGLGDLCDNCPFDFNPLQIDTDDDNVGDECDTDEDVDGDGHQDNLDNCPDIPNASQKDHDNDGIGDACDPDDDNDGVTDADDNCRLVFNPSQNDTDENGRGDACESDFDGDGVADIMDACPENSMIQRTDLSAFQMVPMDPSGASQLEPNWMVRNHGLELINSDPGLAVGYDEFESVEFSGTFYVNTAKDDDYAGFIFGYQSNHRFYAVMWKQVTQKYWQPDPSPAEATAGLQLKLINSTTGPGEYLRNAMWHTGDTENQVKLIWSDPNKIGWKDFTAYRWTVQHRPIDGFMQVTAWEGSNVLADSGPLYDSTLRGGRLGLQEMVFFSDMEYRCLSD >XP_039248576.1 thrombospondin-1-like [Styela clava] -MKILQVLLAAGDKVHDVFTMTNFLSKSKYVRQTDSYNNFLPAYRFRRPTTTLDLTQFRSLANQEFVLLMSLRNDFTKKGTLLSVTPKDGDFLEIVTDPVKGHLSVFGFSQNKFVHAFETGQEGAWTNFSLWVMTLYHNCDYVGQFSHNDTLIPMFDVNHLATGFKKAKFRGSLARIRFYVGATVAEVLAQETKLSRDTEDIGAPGVQVCDLSCDDIRKLAS-VRPPSDYYEGKPEVMDF------------------PRKSCWDDTVRYDDGEQWKRDDCQVCNCTGKVTCVVEKCNALPCIDVVEVEGQCCPECA---SEAIGYSQWSEWTACSVTCGIGQQQRGRACDKVHFTCDLKTKESRNCVLEPCDRKVKLDGGWSYWSPWGPCSVSCGEGVNTRIRECNAPAPQLGGKDCEGASRENRVCKGDPCPIDGGWGPYTPFSRCSATCGGGFKKRTRECNNPAPLFGGKYCVGDKTNISCSEKTCPINNCLRNPCYPGVTCTPHDDGSYECGTCPEGMQGDGGQCEDIDECKLVPDACFHYEHRCQNYPGGYSCMPCPMGHKGDIPTGTGVEYAIAHKQECVVSNPCTDGTNPCSENAECIPTITPPFMCKCHPGYSSRGFVCLEDADLDGIPDVDSSCMKDGVNTLKGDNCLNLPNSGQENADGDEFGDACDRDADNDGIVNERDNCPLIHNPTQHDSDRDGFGDVCDNCPFVRNPGQIDTDNDGLGDECDPDIDGDEILNSDDNCPYVHNPNQRDTDKDGVGDACDNCPNVINKDQSDADSDLVGDACDTDLDRDKDGVQDDLDNCPFVPNSGQADHDKDRIGDECDNDDDNDGILDKDDNCRLIHNPDQKDSDGNGRGDVCEEDFDGDNIKDFEDACMDNALITKTDFTHFDMVKLDPTGTAQIDPNWVIRNKGKEIKNCDPGLAVGKDMFNGVDFEGTFYVNTGNDDDYAGFVFGYQSSSRFYVLMWKQKTQSYWRAYPRQANAEAGLQLKVVESTTGPGEYLRNALWHTGDTPGQVRTLWTDSMHQGWQDHSAYRWTLNHRPETGEIRVTMYNGKKLLTDSGRIIDRTYAGGRMGMQEMVFYSDMKYKCSDS >CAE1249094.1 THBS2S [Sepia pharaonis] --------MIA-----------------------------------------AQFRRKPEIGYNELSLVGEIQNRRRGRATLLRAENLANTKFDSYIDFQRAEVVINLTKDGRYAVRFLTGSENKNKKIIIRFIQLFVNCMNAGRDNTELPV--------LMGNFSVQR-------FKLYGQASLKELLMMQGAPTRPSLPSWVGSIDTIDSVKPELP---NAIVELTIAIRDLQDFQNQIRETHLLKETL---------------------------KECQMCRGTPGNLR--------RCSNPCFQGVRCI-------DTEEG-------FRCG-SCPPGFYGDGKTCSAY-----------LTCNDRPCYPGVQ----------------------------CSD---TSSGFICG------------PCPT-------------------TLTGDGTVCHPTRV------------------------TCDSSPCFPGVMCTDQRTG-FHCGSCPTGYTGNGTYCEDLDECQ-FSRPC---DATCTNLSPGFTCTPCPQGYTSSPITGIGILSAQQTRQICQDIDECRSNNGGCVPHSRCIRPESSTHECQCSIGYGGDGYYCSKDQDLDGIPDNALPCGHR---KCRKDNCVSTPNSGQEDADGDGLGDACDPDADNDGIVNNPDNCPLVANPDQDDTEDDRKGDACDNCPTIPNPEQTDTDDDGMGDTCDPDADNDGIINAHDNCIRVKNADQRDTDGDGIGDACDNCPFVPNVKQLDSDADLTGDACDTNDDKDDDGVQDTNDNCPHIANSDQLDTDGDTLGDICDNDDDNDGVLDVNDNCPLRMNPRQEDEDGNGVGDICEIDKDGDGSEDFIDVCPHNGNIYATDFRAYQTVILDPEGDSQIDPNWVILNQGAEIMNSDPGIAISYTAFAGVDFSGTFYVNTEVDDDYAGFIFSYQDSSHFYVVMWKKNTQTYWHSTPFRAVAEPGIQLKLVNSSTGPGQYLRNALWHTGDTHDQVRLLWKDPRNEGWKERKAYRWELIHRPYKGLIRILFFEETELIADSGNIYDFTLKGGRLGVQEMVIWSDLVYRCNDY >AAK55517.1 putative thrombospondin [Drosophila melanogaster] LLIGLTALALT-----------------------------------------LSLDASAELEGDVVISTRHIRPRRKLH---ISIEALFKHKMSFFLDRKQQRVTLDISANGAESRNFEIPETSTIRSLALQFITLHVDCKASTHHDIDMNLYTQMDDP-VIKLFRERK-------YPLHFDGDMEHSLQRANRGNRRMLRNKITEREVVDHRHQEVPALARSLSDLLALVKLLRDVAHQRQEIAYLRMLL---------------------------ENCAGCKN-PLTTDNQLRIEP-DCANPCYPGVECL-------DSAAG-------PRCG-HCPLGFIGDGKSCKP-----------GVTCAHHMCYPGVQ----------------------------CHD---TVNGAQCD------------SCPA-------------------GYEGDGRTCSLRNP-------------------------CLDTPCPSGAQCLQVGYPYFHCISCPMGHEVNGTSCRDMNECL-LYDPC---DATCTNLSPGFQCSPCPVGFDGTHAHGYFADYVDYRRQTCLDVDECRTGFFRCPEHSTCIRMDNIRHKCHCNVGWAGNGLICGRDTDVDGWPDQAIGCPEL---HCQRDNCPKLPNSGQEDADLDGHGDGCDDDADGDNVQNSQDNCWLAYNTEQLDSDGDKVGDVCDNCVLKYNPRQLDTDEDGLGDECDGDIDNDSIPNALDNCPLLPNPSQSDVDNDGVGDACDNCPNLPNPDQKDRDMDFVGDACHRDIDGDDDGVPNSLDNCPMVSNSDQLDTDGDGTGDECDDDMDGDGIPNYKDNCPLAKNPKQDDFNRNGKGDSCEDDEDVDGVPNGMDNCPNNSMIHHTDFRTLQTIPLDPKGLSQADPNWVVHANGTEILNSDPGLAVGKDAFGGVDFDGTFYINDDTDDDYAGFVFSYQSSYKYYVVQWKKGTQTYWEPRPFTASAAPGIQIKLVNSTEGPGPMMRNSLWHEGNTDGEARLLWKDPKNIAWKERTSYRWSLVHRPAIGLIRLQMHEGNRLIFDSGNVFDSTLKGGRLGVQRMIIWSNLQYKCNNR >XP_397221.5 cartilage oligomeric matrix protein isoform X1 [Apis mellifera] ITLIITIFFLV-----------------------------------------ITRD--EDLEDDFVIVFSNIKSKKKQFQVM--VEVLLKSKMVLMLDRRAKRVILENDEVGHVAQYINMDSNFPSKNVIFLVMAVYIDCIYRGVIPLKKTLTNSEDNL-LIEAFRERKLARSMEAVDLFEDTDQIDLNSRQSRDRSNRDRNKYLEFDPINIYHKRVPQIVKTLNELIGATKKIWEIELNRLETHRVLLLI---------------------------ENCAACREPPLTTT---TPAPPSCKSPCFPGSECR-------DTPRG-------PQCG-ACPPDYTGDGYRCVKI------------TCAHNPCFKGVR----------------------------CYD---QSDRYSCG------------NCPI-------------------GYIGNGKHCELKNV-------------------------CEPNPCYSEVQCDLISEPFYRCGVCPNGFTGNGSVCVDINECE-IAQPC---SVQCINLHPGFRCDPCPPGYTGTMIEGVGLEIAMNRKQICQDINECENNNGGCDPYMECICIDTNVYSCRCRVGWTGDGLICGIDRDNDGIPDRNLHCRDR---HCRMDNCPLTPNSGQEDADRDGIGDACDPDADDDGVLNSSDNCPFISNPGQEDNDSDLVGDICDNCPRVRNPKQEDTDDDGIGDACDPDIDNDGIPNNQDNCQKIKNQNQNDMDEDGIGDACDNCPYGYNPNQLDQDGDGVGDDCDNDNDRDRDGVQDDRDNCPDVANSGQNDDDHDGIGNECDNDMDNDGVPNSNDNCPYVYNPDQRHTHNNFIGDACWHDYDNDTVKNIHDNCPNNSLIWATDFRKYTTIALDPFGTAQEDPVWVIHNDGAEIVNSDPGIAIGPDIFSGVDFEGTFFVDDDGDDDFVGFVFSYQDNRRFYIVAWKKAHQPYWVPTPFRAVGDPGIYLKLVDSDTGPGEILRNSLWHNENTINQVKILWHDPKKIGWKERTSYRWQLLHRPKIGLIRFRLYQGKQLMADSGNVYDSTLKGGKLGVQEKITWSNLLYVCKET >XP_031556620.1 cartilage oligomeric matrix protein-like [Actinia tenebrosa] LQSLLVLLSMV-IQDFDLIKSFELGKGITGLGRIEGPGEPEEAYRFDRGLARLHLGFVSDLASKSLTITSNLKLDRKSYGTLLSIETEGNLVFSLLFSCFSSCRISLYYPEGSTSVTYFDKSDGKWHKMVLHIVSLFMDCRSLGKKKISAGLFPLSNEKRFAQRGASNSWKGSLQSVLLIFGVRSHSFANPVDKNNRHKVKVVTTQRRVLTTSDEKLDDMIRQLSALRKTIEMLRDLNSQSQEVRYVRSFL---------------------------EHGGACKSG-------------------------------------------------------IQQTGKRFDSI-----------------------------------------------------------------------------------------------------GTILPGRKTDRQNPVAGGK--------------------CLQKPCFPFVECYETPDEGFRCGPCPPGFTGNGIRCEDVNECNLY--PC---STKCINLRPGYQCTPCPVGYLGNASMGLGVEMARKNKQVCEDINECANGNGGCSIHSECIRNDGRNYECKCKPGYGGDGVRCGKDSDMDGYPDRALGCKGP---KCAKDNCREIPNSGQEDVDGDGTGDACEYDADGDKPSKDQDNCPSVPNEDQQDTDADGVGDACDNCQTVNNPDQEDTDKDGIGDACDVDIDGDGIINVLDNCPKVPNRDQKNTDGDPHGDACDNCKRGKNPDQADKDGDGIGDVCDFDQDYDRDGVDDRHDNCLRKPNAAQLDTDGDGLGDVCDSDDDNDGIPDYKDNCRLVRNVDQKDSDNDGIGDACQGDYDNDGVPDAVDICPYNHNITKTDFSSFFNVNFDPLSKIKDYPQWKASKKGNEVKNSNVGLFVATPKYEDIEFRGTMFVNTHQDDDIIGFAFGYQQYGHFFLLSWKRKEQMYWIVNPFRATAKTWLTLKRVKSSSVPSHGIRNALWHTAETRRHTKVLWQKRLTRGWKPKTAYRWELNYTPSNGYLRLQMWVGTQQLMDTGILRDLEMRGGRLGFQGDIIWSDLQVRCVDG >NP_001361951.1 Peptidase M12B domain-containing protein [Caenorhabditis elegans] FYIVITFLLSTHLNEEELKQVFGVSNKYSLIEATRHLKNGNLKMKFTAWNDTYHLNVSPHIIDDDVTTYAGLRGEVKSHGNMAAISDCGMEDHFLVLQTLPKRVH---HLQKEHLVYKRSAAESKIREEITRLTHLHFNYTIPTSAQLDSSIFPNMDPIKLFEHFEREYFSLALINVHVLYQQDTYEMWRTQPKNGQAQLLDAFCRYQPVARMCDPLFSLVEGLHEMGHNMGMVHGVQNQCNKGCCLMSAVNGAGK----------------------TTWSDCSVRNAFLLQLDESGRGNCASPGLISTNHLS------DLRLPGQRFTADQQCSYFWGRDYKPNGKAMDDI-------------CRILWCGNSGS---------------------------TISTAHPALEGSWCGAN----KWCGLTPVPIDGEWSEWGPIQQCAVSGSITVQGQHRDCVNPAPNNGGKTCEGANIRGVC--------GATSSNCFGNKICSSIKYDKPDQQLTGEGFEHSTQPCR----CHLIGSELIR--------NKGQFPDGTPCGFDAYCVGGQCLALSCDNKALVEQPEDCPRIGRSVHQWEEWS----SWSECSVSCGLGGRERKCSSGRKCQGVSEESRPCEGV------LRDC-------EEFGEWKEWGSCSEKCAL--GVQKRTDQCSSKHLQEERPCDNWTNWDEWSSCSQSCGGGRRYRIRKCLDDKC----DGDDLEKESCNTQKCISQSWGDWLPCSV-----SCGIGFQIRERLCD----GELCATANKQARTCNQQEWTTCSATCGEGLQSRERSCRRGSCTEDDASQTRRCVNGPCEHSYDSRKRIAKCDGTTENCQDKIDEETCDSFGPISPRRKLITSNDLRKAFGRPLLPIESIHSEPCSVTCGSGRRVLNSCLELFIWSDWSSCSKSCGQDGIQTRQNAECSSYAESRRSENGFDAPRWSEWSS--WSADPTVQGFCAGAILEQIPCAPGSCSPSAGSLWSEGDTGHQIRVCSDEKVDGGWTDWTAWRFCANPKPSQGGAQCTGSDARCHLRDGGPACDHESDGGNCGIQPCFGRSSEITECRQS >tr|E7F1S4|E7F1S4_DANRE Thrombospondin 2b OS=Danio rerio OX=7955 GN=thbs2b PE=3 SV=1 CFRLLALLLLFDETIFDLFESSGITRKTIGVKLFKGLDSDAPAYRFIRFDQLPSVSALQQLLNEGFILTATLRQDRTSRGTILALEGPGRRQLEIVSDGRTNTLDLVYWADGSNVISFEEVSDSQWKNITLYVATLYIGCGLIDSFILDEPFYEHLSATFVAKGSTRESFRGLLQNVRFIFDTQLEDILESRGEANKVSESAEFVEVPMCERSCEELANLFQELKGLRVVVSNLIGLQKVTEENTAMKEALNKMQSLSEQSMCWQDGRMFEDKEDWIVDSCTKCTCQGKVVCRQITCPPVACANPSFIDGECCPVCL-PMDSEDGWSPWSEWTQCTVTCGSGTQQRGRSCDDTSNTCSGPSIQTRKCSLGKCDRRVRQDGGWSLWSPWSSCSVTCGEGLITRIRHCNAPVPQRGGKDCEGEGRETQSCHTDPCPIDGGWGPWSPWAACSATCGGGLKSRVRECNSPEPQHGGRKCLGDSIENVCNRLECPIDGCLSNPCFSGVECNTASDGSWECGPCPNGYRGNGTSCEDVNECNMVSDLCHKVGQQCVNTDPGFHCLPCPPRYKGTQPYGMGVESAKTNKQVCEPYNPCKDNSHSCHKFAECIHFTDPMYKCECRIGYAGDGIICGEDFDLDGWPNQDLVCGANATYHCKKDNCPTLPNSGQEDFDNDGQGDACDKDDDNDEIVDERDNCPLMYNPRQYDYDKDDVGDRCDNCPYEHNPAQTDTDNNGEGDACSVDMDGDEILNERDNCPLIYNTDQKDTDLDGVGDQCDNCPLVHNPQQTDSDNDLVGDQCDNNQDIDEDGHQNNMDNCPYIPNANQADHDGDGKGDACDFDDDNDGIPDDRDNCRLVPNKDQEDSDGDGRGEACENDFDNDNVPDIFDACPENSGISVTDFRKFQMVHLDPKGTTQIDPNWVVRNQGKELANSDPGIAVGFDEFSAVDFSGTFYVNTDRDDDYAGFVFGYQSSRRFYVVMWKQITQTYWEEKPSKAFGISGVSLKVVNSTTGTGEILRNALWHTGNTKHQVRTLWHDPKNIGWKDFTAYRWHLIHRPKTGFIRVVVYEGKQIMADSGPVYDKTFAGGRLGLQEAVFFSDLKYECRDN >tr|F8W5Z7|F8W5Z7_DANRE Thrombospondin 2a OS=Danio rerio OX=7955 GN=thbs2a PE=3 SV=1 NLCLWPLLLLCDESIFDLFKISGISRKTIGAKLFKGHDWDSPAYRFIRFDHIPAVSALHQILNEGFVFVATMRQDKGSRGTLLGVEGPGLRQLEIVSNGRANTLDLVYMVKGSNVVSFEDVSDSQWKNISLYVAHLYVGCSLIDSVILDEPFYELLRPEFVAKGSIRENFRGLLQNVQFLFDTPIENILRNKGEVNVVNESTESVSVGVCERSCEELSNMVQELKGLRIIVGNLIGLQKVTEENTVMKEVLGNMKNIKDKRMCWQDGRLFEDKEDWVVDSCTKCTCQSKIVCHQITCPPVACASPTFLDGECCPLCL-PKDSEDGWSPWSEWTECTVTCGTGTQQRGRSCDATSNPCSGPSIQTRRCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNSPVPQLGGKDCEGSGRETQKCEAKPCPIDGAWGPWSPWAVCSVTCGGGTRTRTRVCNSPRPQYGGKKCPGDSVDTACNKQDCPVDGCLSNPCFGGVECTSSPDGSWECGPCPLGFRGNGKVCEDVNECDMVPDLCYKVGQRCVNTDPGFHCLPCPPRYKGNQPFGMGVEAAKLNKQVCEQENPCKEKTHNCHRSAECIHFSEPMFKCECKIGYAGDGLICGEDSDLDGWPNQNLVCGANQSYHCKKDNCPKLPNSGQEDFDKDGQGDACDKDDDNDGIMDETDNCPLLYNPRQFDYDKDLVGDRCDNCPYEHNPAQIDTDGNGEGDACAVDIDGDEVLNENDNCPYMYNTDQKDTDMDGVGDQCDNCPLLHNPEQTDSDNDRVGDECDNNQDIDEDGHQNSLDNCPYIPNANQADHDKDGKGDACDSDDDNDGVPDDKDNCRLVPNKDQRDSDGDGRGDACKDDFDNDSIPDFMDVCPENDAISNTDFRKFQMVHLDPKGTAQIDPNWVVRHQGKELANSDPGIAVGFDEFNAVDFSGTFYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEDNPSKAIGISGVSLKVVNSTTGTGEHLRNALWHTGDTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADSGPVYDQTFAGGRLGLQELVYFSDLKYECRDN >NP_035711.2 thrombospondin-2 precursor [Mus musculus] MLWALALLALGKDTSFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNDLNRIVKEGFFLTAQLKQDRKSRGTLLVLEGPGQRQFEIVSNGPGDTLDLNYWVEGNHTNFLEDVADSQWKNVTVQVYSLYVGCDLIDSVTLEEPFYEQLEVDYVAKGASRESFRGLLQNVHLVFADSVEDILSKKGEVNTISEHTETLHLSVCTHSCEELSNMMNELSGLHVMVNQLSNLERVSSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWVVDSCTTCTCKFKTVCHQITCSPATCANPSFVEGECCPSCSHSADSDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKPCQRDPCPIDGRWSPWSPWSACTVTCAGGIRERSRVCNSPEPQYGGKDCVGDVTEHMCNKRSCPIDGCLSNPCFPGAKCNSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDICFSTNPRCVNTNPGFHCLPCPPRYKGNQPFGVGLEDARTEKQVCEPENPCKDKTHSCHKNAECIHFSDPMYKCECQIGYAGDGLICGEDSDLDGWPNNNLVCATNATYHCIKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCQLLFNPRQLDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQIDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPDDRDNCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDA >NP_001162609.1 thrombospondin-2 precursor [Rattus norvegicus] MLWALALLALGEDTAFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYVPPVNDLNRIVKEGFFLTAQLKQDRKSRGTLLVLEGPGQRQFEIVSNGPGDTLDLNYWVEGHHTNFLEDVADSQWKNVTVQVYSLYVGCDLIDSVTLEEPFYEQLEADYVAKGASRESFRGLLQNVHLVFADSVEDILSKKGEVNTISEHTETLHLSVCTHSCEELSNMMNELSGLHVMVNQLSNLERVSSDNQFLLELIGGPLKTRNMSACVQEGRIFAENETWVVDSCTTCTCKFKTVCNQITCSPATCANPSLVEGECCPSCSHSADNDEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRTCSLGKCDTRIRQNGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGKNCKGSGRETKACQRAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKDCVGDVTEHMCNKRSCPIDGCLSNPCFPGAKCNSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVADICFSINSRCVNTNPGFHCLPCPPRYKGTQPFGIGLEDAKTEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNSNLVCATNATYHCVKDNCPKLPNSGQEDFDKDGIGDACDEDDDNDGVSDEKDNCPLLFNPRQLDYDKDEVGDRCDNCPYVHNQAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQMDQDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNSNQADHDNDGKGDACDSDDDNDGVPDDRDNCRLVFNPDQEDSDGDGRGDICKDDFDNDNVPDIDDVCPENNAITETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGYMRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDA >NP_789861.1 thrombospondin-2 precursor [Bos taurus] MLWPLLLLALWEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSHLGRITKEGFFLTASMKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFALDEPFYEHLQTEYVTKGAARESFRGLLQNVYLVFENSVEDLLSKKGETNAISENTETLHLSVCEHSCEELGSMIRELSGLHVIVNQLHNLRKVSNDNQFLWELIGGPPKTRNVSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGRCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGGAKEQMCNRKSCPIDGCLSNPCFPGAECSSFPDGSWSCGSCPGGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCVKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVSDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPHIPNANQADHDRDGQGDACDSDDDNDGIPDDRDNCRLVANPDQEDSDGDRRGDACKDDFDNDSIPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_015139537.2 thrombospondin-2 isoform X1 [Gallus gallus] LLWLAVFITLWEENTFDLLQISNINRKTIGAKLFRGPDPAIPAYRFIRFDHIPPFKKLKKIVNEGFILSATLRQDRQSRGTILALEGPGERQFEIISNGRANTLDLIYWVDGFNVISLEDVADSQWKNLTVQVYNLYVGCDLIDSFILEEPFYEQLKAEYVAKGSIRENFRGLLQNIHLIFDTSIEDVLRKKGEVNTINESTEILHLSFCDRSCEELGTMFTELTGLRIVVNNLANLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADSESWIVDSCTKCTCQSKIVCHQITCPPVSCADPSFIEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPIPQMGGKNCVGNGRETEKCEKAPCPVNGQWGPWSPWSACTVTCGGGIRERSRLCNSPEPQYGGKPCVGDTKQHMCNKRDCPIDGCLSNPCFPGAECNSYPDGSWSCGPCPAGFLGNGTVCEDLDECIAVSDVCFKVNHRCVNTNPGFHCLPCPPRYKGSQPYGVGLEVAKTEKQVCEPENPCKDKTHSCHKSAECIHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNNNLVCAANATYHCVKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDPDDDNDGIPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDDDNVPDIFDVCPENNAISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRLGLQEMVYFSDLKYECRDA >XP_024213293.1 thrombospondin-2 [Pan troglodytes] MVWRLVLLALWKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNDLSKITKEGFFLTAQLKQDGKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHVVSLEDVADSQWKNVTVQVYSLHVGCDLIDSFALDEPFYEHLQAEYVAKGSARESFRGLLQNVHLVFENSLEDILSKKGEINAISENTETLRLGVCERSCEELGNMVQELSGLHVLVNQLSNLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTSCTCKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSPRCVNTQPGFHCLPCPPRYRGNQPVGVGLDAAKTEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_043312836.1 thrombospondin-2 [Cervus canadensis] MLRPLLLLALWEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSHLGRIAREGFFLTASLKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFALDEPFYEHLQTEYVAKGAARESFRGLLQNVYLVFENSVEDLLSKKGEANAISEDTETLHLSVCEHSCEELGSMIRELSGLHVIVSQLHNLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRETKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHMCNRKSCPVDGCLSNPCFPGAECSSFPDGSWSCGACPMGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >KAF4024738.1 hypothetical protein G4228_016622 [Cervus hanglu yarkandensis] MLRPLLLLALWEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSHLGRIAREGFFLTASLKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFTLDEPFYEHLQTEYVAKGAARESFRGLLQNVYLVFENSVEDLLSKKGEANAISEDTETLHLSVCEHSCEELGSMIRELSGLHVIVSQLHNLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRETKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHMCNRKSCPVDGCLSNPCFPGAECSSFPDGSWSCGACPVGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRGE >XP_018118557.1 thrombospondin-2 [Xenopus laevis] LLLLHILISFGDETNFDLFEISNINKRTIGAKIFRGHESSSPAFRFLRFDHIPPVNKVKQITNEGFILTATMRQDKHNRGTLIAIEGPGNRLFELVSNGRANTLDLIYWVDGSNVISLEDVADSQWKNITVQLFNLYIGCDLIDSFQLEETFYEHLKADFLAKGSIRGNFRGLLQDVRLIFDISIEDVLRKKGEVNTISEKTEILHLSFCDHSCDELGSMFTELTRLRILVNNLLNLQKVSEENQVLWELIGPNKTLKNQSMCWQDGRVFADNEDWIVDSCTKCTCQSKTVCHQITCPPVHCASPSFIDGECCPMCF-PMDSEAGWSPWSEWTECSVTCGSGTQQRGRSCDATSSSCEGSSIQTRTCHPGKCDNRIRQDGGWSHWSPWSACSVTCGIGNITRIRLCNSPKPQLGGKNCTGAGRETKQCEGIPCPINGKWGPWSPWSSCTVTCGGGLRERSRLCNNPKPQYGGKKCGGEPKEKMCNKQDCPIDGCLSNPCFPGAECNSYPDGSWSCGACPVGFVGNGTFCEDLDECALVSDACFQLGHRCVNTDPGYHCLPCPPRYKGTQPFGVGIEVAKKDKQECEPINPCKDKSHNCHKYAECIHFSDPSYKCECRTGYAGDGIICGEDSDLDGWPNNNLICAANATYHCIKDNCPLLPNSGQEDFDKDGVGDACDKDDDNDGVDDEKDNCPLLYNPRQFDYDKDEVGDRCDNCVYVHNPAQIDTDNNGEGDACAADIDGDDILNELDNCPYVYNTNQKDTDMDGVGDQCDNCPLMHNPDQTDVDNDLVGDQCDNNEDIDEDGYQNNLDNCPYIPNANQADHDKDGRGDACDSDDDNDGVPDERDNCRLVYNPDQKDSDGDGRGDACKDDFDNDSIPDIFDVCPENSDISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGFDEFSAVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPSRAYGYSGVSVKVVNSTTGTGEHLRNALWHTGNTPGEVRTLWHDPKNVGWKDYTAYRWHLTHRPKTGFIRVVVYEGKQIMADSGPLYDKTYAGGRLGLQEMVYFSDLKYECKDF >OWK09861.1 THBS1 [Cervus elaphus hippelaphus] LAWGLAVLLLSDNSVFDIFELTGAARKGSGRRLVKGPDPSSPAFRIEDANLIPPVPKFQDLVEKGFLLLASLRQMKKTRGTLLAVERKDGQLFSVVSNGKAGTLDLSLTVQGKHVVSVEEAATGQWKGITLFVAQLYIDCEKMENAELDVPIFTRDLASRIAKGGVNDNFQGVLQNVRFVFGTTPEDILRNKGDNNVVNGSS------ICGISCDELSSMVLELRGLRTIVTTLQSIRKVTEENKELANEL------RRPPLCYHNGVQYRTGDEWTVDSCTECRCQSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSVTCGNGIQQRGRSCDSLNNRCEGSSVQTRTCHIHECDKRCV----------------------ITRIRLCNSPSPQMNGKPCEGKARETKACQKDACPINGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCIGDVTENICNKQDCPIDGCLSNPCFAGVQCTSYPDGSWKCGACPPGYSGDGVACKDVDECKEVPDACFNHNHRCENTDPGYNCLPCPPRFTGSQPFGRGVEHATANKQVCKPRNPCTDGTHDCNKNAKCNHYSDPMYRCECKPGYAGNGIICGEDTDLDGWPNEDLVCVANATYHCKKDNCPNLPNSGQEDYDKDGIGDACDDDDDNDKIPDDRDNCPFHYNPAQYDYDRDDVGDRCDNCPYNHNPDQADTDNNGEGDACAADIDGDGILNERDNCQYVYNVDQKDTDMDGVGDQCDNCPLEHNPDQLDSDSDRIGDTCDNNQDIDEDGHQNNLDNCPYVPNANQADHEKDGKGDACDHDDDNDGIPDDRDNCRLVPNPDQKDSDGDGRGDACKDDFDQDKVPDIDDICPENVDISETDFRRFQMIPLDPKGTSQNDPNWVVRHQGKELVNCDPGLAVGYDEFNAVDFSGTFFINTERDDDYAGFVFGYQSSSRFYVVMWKQVTQSYWDTNPTRAQGYSGLSVKVVNSTTGPGEHLRNALWHTGNTPGQVRTLWHDPRHIGWKDFTAYRWRLSHRPKTGFIRVVMYEGKKIMADSGPIYDKTYAGGRLGLQEMVFFSDLKYECRGR >NP_001184085.1 thrombospondin-2 precursor [Canis lupus familiaris] MLGALVLLALWEDMAFDLFRISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSYLSRIAKEGFFLTASLKQDPKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLIDSFTLDEPFYEQLRTEYVAKGSARDSFRGLLQNVHLVFENSVEDVLSKKGEANAISENTETLHLSVCERSCEELSTMITELSGLHVIVNQLHNLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQITCPPATCANPSFVEGECCPSCFHSLDGEEGWSPWAEWTECSTTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDNRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKGCQGVPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQMCNKRSCPIDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFTTSHRCVNTNPGFHCLPCPPRYKGSQPFGVGLEAARTEKQVCEPENPCKDKTHACHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVDDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVFNPGQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENSAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_013847876.1 thrombospondin-2 isoform X1 [Sus scrofa] MLWPLLLLASGEDTAFDLFSVSNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVGPLGRIAKEGFFLTASLKQDRKSRGTLLALEGPGRRQFEIVSNGPADTLDLTYWVDGAHVISLEDVADAQWKNVTVQVYSLYVGCDLMDSFTLDEPFYEQLKTEYVAKGSARESFRGLLQNVFLVFENSVEDLLSKKGEANAISENTETLHLSVCEHSCEELGSMIQELSGLHVIVSQLHNLRKVSNDNQFLWELIGGPPKTRNVSACWQDGRFFAENETWVVDSCTKCTCRFKTVCHQITCPPATCADPAFVDGECCPSCFS--DGEEGWSPWAEWTECSATCGPGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGRGCKGSGRETRACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQMCNKRSCPVDGCLSNPCFPGASCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFTTSHRCVNTDPGFHCLPCPPRYKGSQPFGVGLEAARTEKQVCEPENPCEDKTHNCHRHAECVHFSDPMFKCECRTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVSDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDSNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDVDEDGHQNNQDNCPYISNANQADHDHDGKGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_017195335.1 PREDICTED: LOW QUALITY PROTEIN: thrombospondin-2 [Oryctolagus cuniculus] MLWGLALLALWEDTSFDLFSISNINRKTIGAKQFRGPEPGAPAYRFVRFDYIPPVNDLLRITRDGFFLTAQLKQDRKSRGTLLALEGPG-RQFEVVSNGPADTLDLTYWTDGGHVLSLEDVADSQWKNITVQVFGLYVGCDLIDSFALDEPFYEQLTADYVAXGAARESFRGLLQNMHLVFENSVEDVLSKKGEINAISEHTETLHLSVCEHSCAELGNMISELSGLHLLVDQLSNLRRVSSDNQFLLELIGVPPKTRNVSGCWQEDRMFAENETWVVDSCTTCTCKFKTVCHQITCSPATCANPSIVEGECCPSCSHA-DGEEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDARVRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKSCKGSGRETKACEGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKACVGDVKERMCNRRSCPVDGCLSNPCFPGAECSSFPDGSWSCGACPVGYLGNGTYCEDLDECAVVTDVCFSTSARCINTQPGFHCLPCPPRYKGSQPSGVGLEAARAEKQVCEPENPCKDKTHSCHKQAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNSNLVCATNATYHCLKDNCPHLPNSGQEDFDKDGVGDACDDDDDNDGVSDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYVANANQADHDNDGKGDACDPDDDNDGIPDDRDNCRLLFNPDQEDSDGDGRGDICKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPSRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDHTYSGGRLGLQEMVYFSDLKYECRDV >XP_024104045.1 thrombospondin-2 [Pongo abelii] MVWRLVLLALWKDTTFDLFSISNINRKTIGAKQFRGPDPGMPAYRFVRFDYIPPVNDLSKITKEGFFLTAQLKQDGKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHMVSLEDVADSQWKNVTVQVYSLHVGCDLIDSFALDEPFYEHLQAEYVAKGSARESFRGLLQNVHLVFENSVEDILSKKGEINTISENTETLRLGVCERSCEELGNMVQELSGLHVLVNQLSNLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTECSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQLGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKTCVGDVQERMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSPRCVNTQPGFHCLPCPPRYRGSQPVGVGLEAAKMEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDMDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNVPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_003204105.2 thrombospondin-2 [Meleagris gallopavo] LLWLAVLITLWEENTFDLLQISNINRKTIGAKLFRGPDPAIPAYRFIRFDHIPPFKKLKKIVNEGFILSAILRQDRQSRGTILALEGPGERQFEIISNGRANTLDLIYWVDGFNVISLEDVADSQWKNLTVQVYNLYVGCDLIDSFILEEPFYEQLKAEYVAKGSIRENFRGLLQNIHLIFDTSIEDVLRKKGEVNTINESTEILHLSFCDRSCEELGTMFTELTGLRIVVNNLANLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADSESWIVDSCTKCTCQSKIVCHQITCPPVSCADPSFIEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPIPQMGGKNCVGNGRETEKCEKAPCPVNGQWGPWSPWSACTVTCGGGLRERSRLCNSPEPQYGGKPCVGDTKQHMCNKRDCPIDGCLSNPCFPGAECNSYPDGSWSCGPCPAGFLGNGTVCEDLDECIAVSDVCFKVNHRCVNTNPGFHCLPCPPRYKGSQPYGVGLEVAKTEKQVCEPENPCKDKTHSCHKSAECIHFSDPMYKCECRTGYAGDGHICGEDSDLDGWPNNNLVCAANATYHCVKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDPDDDNDGIPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDNDNVPDIFDVCPENNAISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRLGLQEMVYFSDLKYECRDA >XP_003820249.2 thrombospondin-2 [Pan paniscus] MVWRLVLLALWKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNDLSKITKEGFFLTAQLKQDGKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHVVSLEDVADSQWKNVTVQVYSLHVGCDLIDSFALDEPFYEHLQAEYVAKGSARESFRGLLQNVHLVFENSVEDILSKKGEINAISENTETLRLGVCERSCEELGNMVQELSGLHVLVNQLSNLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTSCTCKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERMCNKRSCPVDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSPRCVNTQPGFHCLPCPPRYRGNQPVGVGLDAAKTEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSHFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_006932208.1 thrombospondin-2 isoform X1 [Felis catus] MLWDLVLLALWEDTAFNLFSISNINRKTIGAKQFRGPDPNVPAYRFVRFDYIPPVSYLSKIAKEGFFLTASLKQDPKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGAHVISLEDVADSQWKNITVQVYSLYVGCDLIDSFTLDEPFYEQLRTEYVAKGSARDNFRGLLQNIYLVFENSVEDVLSKKGEANAISENTETLHLSVCERSCEELGTMITELSGLHVIVNQLHNLRKVSNDNQVLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQITCPPATCANPSFVEGECCPSCFHSLDGEEGWSPWAEWTQCSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKGCQGTPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVQERMCNKRSCPVDGCLSNPCFPGAECSSFPDGSWSCGACPVGFLGNGTHCEDLDECAVVTDVCFAVGQRCVNTNPGFHCLPCPPRYKGTQPFGVGLEAARTEKQVCEPENPCKDKTHACHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCSTNATYHCIKDNCPLLPNSGQEDFDKDGTGDACDDDDDNDGVDDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDIDNDLVGDQCDNNDDIDDDGHQNNQDNCPYIPNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVSNPGQEDSDGDGRGDACKDDFDNDSIPDIDDVCPENSAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEEQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_027828484.1 thrombospondin-2 [Ovis aries] MLRPLLLLALWEDTAFDLFSLSNINRKTIGAKQFRGPDPHTPAYRFVRFDYIPPVSHLGRIAKEGFFLTASLKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFALDEPFYEHLQTEYVAKGAARESFRGLLQNVYLVFENSVEDLLSKKGEANAISENTETLHLSVCEHSCEELGSMIRELSGLHVIVNQLHSLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCRFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRGCKGSGRETAACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEQMCNRKSCPVDGCLSNPCFPGAECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDSNGEGDACSADIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDDNEDIDEDGHQNNQDNCPYIPNANQADHDRDGRGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_018885551.1 thrombospondin-2 [Gorilla gorilla gorilla] MVWRLVLLALWKDTTFDLFSISNINRKTIGAKQFRGPDPGVPAYRFVRFDYIPPVNDLSKITKEGFFLTAQLKQDGKSRGTLLALEGPGQRQFEIVSNGPADTLDLTYWIDGTHVVSLEDVADSQWKNVTVQVYSLHVGCDLIDSFALDEPFYEHLQAEYVAKGSARESFRGLLQNVHLVFENSVEDILSKKGEINAISENTETLRLGVCERSCEELGNMVQELSGLHVLVNQLSNLKRVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTTCTCKFKTICHQITCPPATCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQYGGKACVGDVQERMCNKRSCPMDGCLSNPCFPGAQCSSFPDGSWSCGSCPVGFLGNGTHCEDLDECALVPDICFSTSPRCVNTQPGFHCLPCPPRYRGSEPVGVGLEAAKTEKQVCEPENPCKDKTHNCHKHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNLNLVCATNATYHCIKDNCPHLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQADYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDDDGHQNNQDNCPYISNANQADHDRDGQGDACDPDDDNDGVPDDRDNCRLVFNPDQEDLDGDGRGDICKDDFDNDNIPDIDDVCPENNAISETDFRNFQMVPLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGQVRTLWHDPRNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDI >XP_011482880.1 thrombospondin-2 isoform X1 [Oryzias latipes] HLFL--FLSVFDETSFDLFEISHITRKTLGAKQFRGQNLDAPAYRFIRFDFLPPVDILKQILNEGFVFVASMRQDHTSRGTLVALEGPGRRQFEIISNGPANTLDLVYWVDGSNVVSFEDVSDSQWKNITLHIANLFVGCNLLDSFVLDEPFYEHLRAEYVAKGSNRENFRGLLQSVRFIFDTPVESILQNRGDPNTVRESTEVIDVRMCERSCEELSTMFHELKGLRVVVSNLIGLQKVTEENTVMKEALGRMKETKEKNMCWQDGRLFEDKEDWVVDSCTKCTCQSKIVCHQITCPPVACASPSFVDGECCPVCM-PKDSEDGWSPWSEWTECTVTCGIGTQQRGRSCDATSNPCSGPSIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGTDCEGSGRETQNCTATPCPIDGGWGPWSPWASCSATCGGGIKSRTRECNSPQPQHGGKKCLGEASDSSCNKKDCPIDGCLSNPCFGGVDCSSSPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVSQRCVNTNPGFHCLPCPKRYKGTQPFGMGVESAKRNKQVCEPENPCKDKTHSCHKFAECIHFSDPMYKCECRTGYAGDGFICGEDSDLDGWPNQNLVCGANTTYNCQKDNCPDLPNSGQEDFDRDGQGDACDKDDDNDGILDERDNCALLYNPRQFDFDKDEVGDRCDNCPYEHNPAQIDTDHNGEGDACAVDIDGDDIHNDNDNCPYVYNTDQKDTDMDGVGDQCDNCPLLHNPDQSDIDNDLVGDQCDNNQDIDEDGHQNNLDNCPYVANANQADHDKDGKGDACDYDDDNDGVPDDKDNCRLTPNADQVDSDGDGRGDACKDDFDNDSIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDPNWVVRHQGKELANSDPGIAVGFDEFNAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEYKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTQGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADSGPIYDKTFAGGRLGLQELVFFSDLKYECRDK >XP_013224536.2 thrombospondin-2 [Columba livia] LLWLAVLITLWEETTFDLLQISNINRKTVGAKLFRGPDPATPAYRFIRFDHIPPCKKLKKIVNEGFILSATLRQDRQSRGTILALEGPGERQFEIISNGRANTLDLIYWVDGFNVISLEDVADSQWKNLTVQIYNLYVGCDLIDSFILEEPFYEQLKAEYVAKGSIRENFRGLLQNIQLIFDTSIEDVLCKKGEVNTINESTEILHLSFCDRSCEELGTMFTELTGLRIVVNNLANLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADSESWIVDSCTKCTCQSKIVCHQITCPAVSCANPSFVEGECCPVCSHSDDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSACTGPHIQTRMCSFKKCDHRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNCVGNGRETEKCEKVPCPVNGQWGPWSPWSACTVTCGGGIRERSRLCNSPEPQYGGKPCVGDIKQHMCNKKDCPIDGCLSNPCFPGAECNSYPDGSWSCGPCPAGYLGNGTICEDLDECIAVSDVCFKVNHRCVNTNPGFHCLPCPPRYKGSQPYGVGLEIAKTEKQVCEPENPCKDKTHSCHKSAECIHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNNNLVCAANATYHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDSCAVDIDGDDIFNERDNCPYVYNTDQSDTDGDGVGDQCDNCPLMHNPDQTDADNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDPDDDNDGVPDDRDNCRLRYNPEQEDSDGDGRGDICKDDFDNDSVPDIYDVCPENNAISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIKVLVYEGKQVMVDSGPIYDTTFAGGRLGLQEMVYFSDLKYECRDA >XP_017908975.1 PREDICTED: thrombospondin-2 [Capra hircus] MLRPLLLLALWEDTAFDLFSLSNINRKTIGAKQFRGPDPRTPAYRFVRFDYIPPVSHLGRIAKEGFFLTASLKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFALDEPFYEHLQTEYVAKGAARESFRGLLQNVYLVFENSVEDLLSKKGEANAISENTETLHLSVCEHSCEELGSMIRELSGLHVIVNQLHSLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRSCKGSGRETKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDIKEQMCNRKSCPVDGCLSNPCFPGAECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDDNEDIDEDGHQNNQDNCPYIPNANQADHDRDGRGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_025050742.1 thrombospondin-2 isoform X1 [Alligator sinensis] LLWLTFLLTLWEETTFDLLQISNINRKTIGAKVFRGPNPTTPAYRFIRFDHIPPVNKLKQIINEGFILSATLRQDRQSRGTIIALEGPGQRQFEIISNGRANTLDLIYWVDGSNVISLEDVADSQWKNLTVQVYNLYVGCDLIDSFILEEPFYEQLKAEYVTKGSIRENFRGLLQNVNLIFDISLEEVLRKKGEVNTINESTEILHLSFCDRSCEELGTMFTELTGLRVVVNNLVNLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADNEIWTVDSCTKCTCQSKIVCHQITCPAVSCANPSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSSCTGPHIQTRMCSFKKCEHRIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQMGGKNCEGKGRETEKCEKVPCPINGQWGPWSPWSACTVSCGGGIHERSRLCNSPEPQYGGKPCVGDVKQHICNKKDCPIDGCLSNPCFPGAECNSYPDGSWSCGACPSGYLGNGTVCEDLDECIAVPDVCFKVNHRCVNTNPGFHCLPCPPRYKGTQPFGVGLEVAKAEKQVCEPENPCKDKTHQCHKSAECIHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNKNLVCAANATYHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTDTDNDLVGDQCDNNEDIDEDGHQNNQDNCPYIPNANQADHDKDGKGDACDSDDDNDGVPDDRDNCRLRFNPDQEDSDGDGRGDICKDDFDNDSIPDIYDVCPENYDISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIRVSVYEGKQVMVDSGPIYDMTFAGGRLGLQEMVYFSDLKYECKDF >XP_006277456.1 PREDICTED: thrombospondin-2 isoform X1 [Alligator mississippiensis] LLWLTFLLTLWEETTFDLLQISNINRKTIGAKVFRGPNPTTPAYRFIRFDHIPPVNKLKQIINEGFILSATLRQDRQSRGTIIALEGPGQRQFEIISNGRANTLDLIYWVDGSNVISLEDVADSQWKNLTVQVYNLYVGCDLIDSFILEEPFYEQLKAEYVTKGSIRENFRGLLQNVNLIFDISLEEVLRKKGEVNTINESTEILHLSFCDRSCEELGTMFTELTGLRVVVNNLVNLQKVSEENQIMWELIGPNKTLKNQSVCWQDGRVFADNEIWTVDSCTKCTCQSKIVCHQITCPAVSCANPSFIEGECCPVCSQSEDSEEGWSPWSDWTKCSVTCGSGTQMRGRSCDVTRSSCTGPHIQTRMCSFKKCEHRIRQDGGWSHWSPWSSCSVTCGIGNITRIRLCNSPIPQMGGKNCEGKGRETEKCERVPCPINGQWGPWSPWSACTVSCGGGIHERSRLCNSPEPQYGGKPCVGDVKQHICNKKDCPIDGCLSNPCFPGAECNSYPDGSWSCGACPSGYLGNGTVCEDLDECIAVPDVCFKVNHRCVNTNPGFHCLPCPPRYKGTQPFGVGLEVAKAEKQVCEPENPCKDKTHQCHKSAECIHFSDPMYKCECRTGYAGDGRICGEDSDLDGWPNKNLVCAANATYHCMKDNCPLLPNSGQEDFDKDGKGDACDEDDDNDGVEDDKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACAVDIDGDDIFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLMHNPDQTDMDNDLVGDQCDNNEDIDDDGHQNNQDNCPYIPNANQADHDKDGKGDACDSDDDNDGVPDDRDNCRLRFNPDQEDSDGDGRGDICKDDFDNDSIPDIYDVCPENYDISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGYDEFSSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPTRAYGYSGVSLKVVNSTTGAGEHLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGLIRVSVYEGKQVMVDSGPIYDMTFAGGRLGLQEMVYFSDLKYECKDF >XP_015799926.1 PREDICTED: thrombospondin-2 isoform X1 [Nothobranchius furzeri] SLFLL-LLSTFDEMSFDLFEISHITRKTLGAKQFRGQNLDAPAYRFIRFDHLPPVSILKQILNEGFVFVASIRQDRGSRGTLIGLDGPDRRQFEIVSDGRANTLDLVYWVDGSNVFSFEDVSDSQWKNVTLHIANLFVGCSLIDSFILDEPFYENLRAEFVAKGSTRESFRGLLQNVHFLFDTSMEDILLSRDTDNIVSESTEIVDVRMCERSCEELSTMFQELKGLRVVVSNLIGLQKVTEENTVMKEALGRMKDSKEKNMCWQDGRLFEDKEDWVVDSCTKCTCQSKIVCHQITCPPVACASPSLIDGECCPVCM-PKDSEDGWSPWSEWTECTVTCGIGTQQRGRSCDATSNPCSGPSIQTRKCSLGRCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGKDCAGSGRETQKCIAEPCPIDGAWGPWSPWATCSATCGGGVKSRSRECNSPRPQYGGKKCIGEPNDSSCNKEDCPIDGCLFNPCFGGVDCSSSPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVSQRCVNTDPGFHCLPCPKRYKGTQPYGMGIEAAKRNKQVCEPENPCKEKTHSCHKYAECIHFSDPMYKCECRTGYAGDGFICGEDSDLDGWPNQNLVCDANATYHCKKDNCPNLPNSGQEDFDKDGQGDACDKDDDNDGILDDRDNCPLLYNPRQFDFDKDDVGDRCDNCPYEHNPAQIDTDHNGEGDACAVDIDGDEILNENDNCPYVYNTDQKDTDMDGVGDQCDNCPLLHNPDQTDVDNDLVGDQCDNNQDIDEDGYQNNLDNCPYVANANQADHDKDGKGDACDYDDDNDGIPDEKDNCRLTPNEDQLDSDGDGRGDACKDDFDNDNIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDPNWVVRHQGKELANSDPGIAVGFDEFNAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEDKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTAGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADSGPVYDKTFAGGRLGLQELVFFSDLKYECRDK >XP_020762367.1 thrombospondin-2 [Odocoileus virginianus texanus] MLRPLLLLALWEDTAFDLFSISNINRKTIGAKQFRGPDPSVPAYRFVRFDYIPPVSHLGRIAREGFFLTASLKQDRRSRGTLLALEGPGHRQFEIVSNGPADTLDLTYWVDGTHVISLEDVADSQWKNVTVQVYSLYVGCDLMDSFALDEPFYEHLQTEYVAKGAARESFRGLLQNVYLVFENSVEDLLSKKGEANAISENTETLHLSVCEHSCEELGSMIRELSGLHVIVNQLHSLRKVSNDNQFLWELIGGPPKTRNMSACWQDGRFFAENETWVVDSCTKCTCKFKTVCHQISCPPATCADPWFVEGECCPSCVH--DGEEGWSPWAEWTECSATCGPGTQQRGRSCDVTSNTCLGPSIQTRACSLGKCDHRIRQDGGWSHWSPWSSCSVTCGVGNVTRIRLCNSPVPQMGGRNCKGSGRETKACQGPPCPVDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEPQHGGKDCVGDVKEHMCNRKSCPVDGCLSNPCFPGAECSSFPDGSWSCGSCPVGFLGNGTHCEDLDECAVVTDVCFATSHRCVNTNPGYHCLPCPPRYKGNQPFGVGLEAARTEKQVCEPENPCKDKTHSCHRHAECIHFSDPMYKCECQTGYAGDGLICGEDSDLDGWPNKNLVCATNATYHCIKDNCPLLPNSGQEDFDKDGIGDACDDDDDNDGVTDEKDNCQLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACSVDIDGDDVFNERDNCPYVYNTDQRDTDGDGVGDHCDNCPLVHNPDQTDVDNDLVGDQCDNNEDIDEDGHQNNQDNCPYISNANQADHDHDGQGDACDSDDDNDGVPDDRDNCRLVANPDQEDSDGDGRGDACKDDFDNDSVPDIDDVCPENNAISETDFRNFQMVHLDPKGTTQIDPNWVIRHQGKELANSDPGIAVGFDEFGSVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVVMWKQVTQTYWEDQPTRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTEGQVRTLWHDPKNIGWKDYTAYRWHLTHRPKTGYIRVLVHEGKQVMADSGPIYDQTYAGGRLGLQEMVYFSDLKYECRDV >XP_030298404.1 thrombospondin-2 isoform X1 [Sparus aurata] SLFLLLLSFNFDETSFDLFEISHITRKTLGAKQFRGQNSDAPAYRFIRFDHLPPVSILKQILNEGFVFAASIRQDRASRGTLIGLEGPDQRQFEIVSNGRANSLDLVYWVEDSNVVSFEDVSDSQWKNITLHIANLFVGCSLIDSHILDEPFYEHLQAEYVAKGSIRENFRGLLQNVRFVFDTPVEDVLLSRDDANIVSESTEVVDVSMCERSCEELSTMFQELKGLRHVVSNLIGLQKVTEENSVMKEALGRMKNTKEKNMCWQDGRLFDDKEDWVVDSCTKCTCQSKIVCHQITCPAVACASPSFVDGECCPVCL---HSEDGWSLWSEWTECTVTCGTGTQQRGRSCDATSNPCDGPSIQTRKCSLGKCDSRVRQDGGWSLWSPWSSCSVTCGEGQITRIRHCNAPVPQLGGKDCEGSGRETQRCTAQPCPIDGGWGPWSPWATCSATCGGGIKTRMRECNSPQPQHGGRKCIGEANDEGCNKKDCPIDGCLSNPCFGGVDCNSAPDGSWECGPCPAGFRGNGTHCEDINECDMVSDVCYKVAQRCVNTDPGFHCLPCPKRYKGTQPFGMGVEAAKKNKQVCEPENPCKDKTHNCHKYAECIHFSDPMYKCECRTGYAGDGFICGEDSDLDGWPNLNLVCGANATYHCKKDNCPSLPNSGQEDFDKDGQGDACDKDDDNDGILDERDNCPLLYNPRQFDFDKDEVGDRCDNCPYEHNPAQIDTDNNGEGDACAVDIDGDEIMNENDNCPYVYNTEQKDTDMDGVGDQCDNCPLLHNPDQTDVDNDLVGDQCDNNQDIDEDGHQNNLDNCPYVANANQADHDKDGKGDACDYDDDDDGVPDDKDNCRLTPNADQLDSDGDGRGDACKDDFDNDSIPDILDVCPENNAISVTDFRKFQMVHLDPKGTTQIDPNWVVRHQGKELANSDPGIAVGFDEFSAVDFSGTMYVNTDRDDDYAGFVFGYQSSGRFYVVMWKQITQTYWEDKPSKAFGISGVSLKVVNSTTGTGENLRNALWHTGNTPGQVRTLWHDPKNIGWKDYTAYRWHLIHRPKTGFIRVVVYEGKQIMADSGPVYDKTFAGGRLGLQELVFFSDLKYECRDK >XP_040206850.1 thrombospondin-2 [Rana temporaria] LQRLLIFLCFWDETTFDLFEISNINKRTIGVKMFRGHDPNSPAYRFLRFDHIPPVKKMREIINEGFILTATIKQDKRNRGTLLSIEGPGNRMFELVSNGRANTLDLIYWIEGTNVISLEDVADSQWKNITVQLFNLYVGCDLMDSFRLEETFYEHLKADFLARGSIRENFRGLLQKIKLIFDTPVEDILKKKGD-NAISEKTEMIHLSFCDRSCDELSTMFTELSGLRVVVNNLLNLQKVSEENQELWELIGPNKTLKNQSVCWQDGRVFGDNEDWIVDSCTKCTCQSKTVCHQITCPTVHCDSPTFVEGECCPVCF-PLDNEAGWSPWSEWTECSVTCGPGTQQRGRSCDATSSTCAGSSIQTRTCNPGKCDHRIRQDGAWSHWSPWSACSVTCGIGNITRIRLCNSPKPQLGGKNCTGIGRETKECEGVPCPINGKWGPWSPWSSCSVTCGGGLRERSRICNNPKPQYGGKKCGGDTKEKMCNKQDCPIDGCLSNPCFPGSECNSYPDGSWSCGACPVGYIGNGTFCEDLDECTLVTDACFRLGHRCVNTDPGYQCLPCPPRYKGNQPFGVGLEVAQKDKQVCEPINPCKDKSHNCHKSAECIHFSEPSFKCECRTGYAGDGIICGEDSDLDGWPNNNLICAANATYHCVKDNCPLLPNSGQEDFDKDGVGDACDRDDDNDGVDDEKDNCPLLFNPRQFDYDKDEVGDRCDNCPYVHNPAQIDTDNNGEGDACAVDIDGDDILNELDNCPYVYNTDQTDTDKDGVGDQCDNCPLMHNPDQTDVDNDLVGDQCDNNEDIDEDGYQNNLDNCPYIPNANQADHDKDGRGDACDSDDDNDGVPDDRDNCRLVFNPDQKDSNGDGRGDECKDDFDNDSIPDIFDVCPENSGISETDFRKFQMVPLDPKGTAQIDPNWVIRHQGKELANSDPGIAVGFDEFSAVDFSGTFYVNTDRDDDYAGFVFGYQSSSRFYVLMWKQVTQTYWEDKPSRAYGYSGVSLKVVNSTTGTGEHLRNALWHTGNTPGEVRTLWHDPKNVGWKDYTAYRWHLTHRPKTGYIRVVVYEGKLIMADSGPLYDKTYAGGRLGLQEMVFFSDLKYECKDF
PhyML tree of selected proteins (((XP_038078580_1_thrombospondin_1_like_isoform_X1__Patiria_miniata_:0.45240586,XP_030855692_1_thrombospondin_1__Strongylocentrotus_purpuratus_:0.53397442):0.63271264,(OWK09861_1_THBS1__Cervus_elaphus_hippelaphus_:0.38164158,(((((XP_025050742_1_thrombospondin_2_isoform_X1__Alligator_sinensis_:0.00000001,XP_006277456_1_PREDICTED__thrombospondin_2_isoform_X1__Alligator_mississippiensis_:0.00293954):0.03540066,(XP_013224536_2_thrombospondin_2__Columba_livia_:0.00889244,(XP_015139537_2_thrombospondin_2_isoform_X1__Gallus_gallus_:0.0019682,XP_003204105_2_thrombospondin_2__Meleagris_gallopavo_:0.00297742):0.01355469):0.02937509):0.05605016,(((XP_024104045_1_thrombospondin_2__Pongo_abelii_:0.00784179,(XP_018885551_1_thrombospondin_2__Gorilla_gorilla_gorilla_:0.00197219,(sp_P35442_TSP2_HUMAN_Thrombospondin_2_OS_Homo_sapiens_OX_9606_GN_THBS2_PE_1_SV_2:0.00000001,(XP_024213293_1_thrombospondin_2__Pan_troglodytes_:0.00098609,XP_003820249_2_thrombospondin_2__Pan_paniscus_:0.00098395):0.00196778):0.00098271):0.00111226):0.04020324,(XP_017195335_1_PREDICTED__LOW_QUALITY_PROTEIN__thrombospondin_2__Oryctolagus_cuniculus_:0.05924342,(NP_035711_2_thrombospondin_2_precursor__Mus_musculus_:0.00975379,NP_001162609_1_thrombospondin_2_precursor__Rattus_norvegicus_:0.01521674):0.06018864):0.01753695):0.02103596,((NP_001184085_1_thrombospondin_2_precursor__Canis_lupus_familiaris_:0.00874398,XP_006932208_1_thrombospondin_2_isoform_X1__Felis_catus_:0.02894746):0.01141797,(XP_013847876_1_thrombospondin_2_isoform_X1__Sus_scrofa_:0.03262782,((NP_789861_1_thrombospondin_2_precursor__Bos_taurus_:0.0171233,(XP_027828484_1_thrombospondin_2__Ovis_aries_:0.00590107,XP_017908975_1_PREDICTED__thrombospondin_2__Capra_hircus_:0.00118203):0.00627392):0.00299923,(XP_020762367_1_thrombospondin_2__Odocoileus_virginianus_texanus_:0.00198052,(XP_043312836_1_thrombospondin_2__Cervus_canadensis_:0.00099492,KAF4024738_1_hypothetical_protein_G4228_016622__Cervus_hanglu_yarkandensis_:0.00299971):0.00299792):0.00220048):0.01858625):0.01494348):0.01265316):0.15301483):0.03759615,(XP_018118557_1_thrombospondin_2__Xenopus_laevis_:0.0491388,XP_040206850_1_thrombospondin_2__Rana_temporaria_:0.07263737):0.08127397):0.09257758,(tr_F8W5Z7_F8W5Z7_DANRE_Thrombospondin_2a_OS_Danio_rerio_OX_7955_GN_thbs2a_PE_3_SV_1:0.11199064,(tr_E7F1S4_E7F1S4_DANRE_Thrombospondin_2b_OS_Danio_rerio_OX_7955_GN_thbs2b_PE_3_SV_1:0.16987111,(XP_030298404_1_thrombospondin_2_isoform_X1__Sparus_aurata_:0.03715646,(XP_011482880_1_thrombospondin_2_isoform_X1__Oryzias_latipes_:0.05376122,XP_015799926_1_PREDICTED__thrombospondin_2_isoform_X1__Nothobranchius_furzeri_:0.04585781):0.0117934):0.05831586):0.02103416):0.10133819):0.19860212):0.41064512):0.07147366,XP_039248576_1_thrombospondin_1_like__Styela_clava_:0.98907715,(NP_001361951_1_Peptidase_M12B_domain_containing_protein__Caenorhabditis_elegans_:15.09009354,(XP_031556620_1_cartilage_oligomeric_matrix_protein_like__Actinia_tenebrosa_:1.77006879,(CAE1249094_1_THBS2S__Sepia_pharaonis_:1.03668816,(AAK55517_1_putative_thrombospondin__Drosophila_melanogaster_:0.98069314,XP_397221_5_cartilage_oligomeric_matrix_protein_isoform_X1__Apis_mellifera_:1.16680094):0.28498052):0.37133467):0.42296691):0.16576609);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)