PB0060

DATABASE

Click here to access PB0060 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0060	O00584	Ribonuclease T2	RNASET2	RNASE6PL, bA514O12.3	Homo_sapiens	Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512).

Domains

Gene Ontology

PF00445 (Ribonuclease_T2)

GO:0003723 (enables) RNA binding GO:0004518 (enables) nuclease activity GO:0004519 (enables) endonuclease activity GO:0004521 (enables) endoribonuclease activity GO:0004540 (enables) ribonuclease activity GO:0016787 (enables) hydrolase activity GO:0016829 (enables) lyase activity GO:0033897 (enables) ribonuclease T2 activity GO:0002376 (involved in) immune system process GO:0006401 (involved in) RNA catabolic process GO:0045087 (involved in) innate immune response GO:0090305 (involved in) nucleic acid phosphodiester bond hydrolysis GO:0090501 (involved in) RNA phosphodiester bond hydrolysis GO:0090502 (involved in) RNA phosphodiester bond hydrolysis, endonucleolytic GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005739 (located in) mitochondrion GO:0005758 (located in) mitochondrial intermembrane space GO:0005764 (located in) lysosome GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0035578 (located in) azurophil granule lumen GO:0043202 (located in) lysosomal lumen GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|B8XY56|RNT2_DANRE Ribonuclease T2 OS=Danio rerio OX=7955 GN=rnaset2 PE=2 SV=1 MRFIAFAVIFSAVYLCSSAFTHPRGEWTKLILTQHWPQTFCKMEHCKTDFSYWTLHGLWP NTGVRCNTSWHFNASLIEDILPEMEKFWPDLLEPSSPKFWNYEWTKHGTCAAKSESLNSE HKYFGKALELYHKFDLNSVLLKNQIVPSEKHYTLEDVEEAITSAYGVKPKIQCVHPGQGG QVQILGQIEICVDRDFQLMGCEKSSEDTWSNDLPTVPVSGQSGLSVCDHSMPVYYPPVQA >sp|O00584|RNT2_HUMAN Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2 MRPAALRGALLGCLCLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPD YWTIHGLWPDKSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGT CAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIP KIQCLPPSQDEEVQTIGQIELCLTKQDQQLQNCTEPGEQPSPKQEVWLANGAAESRGLRV CEDGPVFYPPPKKTKH
Selected proteins from model organisms >sp|B8XY56|RNT2_DANRE Ribonuclease T2 OS=Danio rerio OX=7955 GN=rnaset2 PE=2 SV=1 MRFIAFAVIFSAVYLCSSAFTHPRGEWTKLILTQHWPQTFCKMEHCKTDFSYWTLHGLWP NTGVRCNTSWHFNASLIEDILPEMEKFWPDLLEPSSPKFWNYEWTKHGTCAAKSESLNSE HKYFGKALELYHKFDLNSVLLKNQIVPSEKHYTLEDVEEAITSAYGVKPKIQCVHPGQGG QVQILGQIEICVDRDFQLMGCEKSSEDTWSNDLPTVPVSGQSGLSVCDHSMPVYYPPVQA >sp|O00584|RNT2_HUMAN Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2 MRPAALRGALLGCLCLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPD YWTIHGLWPDKSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGT CAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIP KIQCLPPSQDEEVQTIGQIELCLTKQDQQLQNCTEPGEQPSPKQEVWLANGAAESRGLRV CEDGPVFYPPPKKTKH >NP_001099680.1 ribonuclease T2 precursor [Rattus norvegicus] MAEARGALPGWVSVLGWGLALCCLCGAGPLWSGSHEWKKLILTQHWPPTVCKEVNRCRDSLDYWTIHGLW PDRAEDCNHSWHFNLNEIKDLLRDMKIYWPDVIHPSSNRSQFWKHEWDKHGTCAAQVDALNSERKYFGKS LDLYKQIDLNSVLQKFEIKPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGENVQTIGQIELCFTKEDF HLRNCTEPEEQPSSGQEARLAREASTHGMMVCEDGPIFYPPPKSQH >NP_001034580.1 ribonuclease T2 precursor [Gallus gallus] MKPAKLHYWILGCFSIVSCCWCTSDQFPQSDSHPHTWKKLYLAHHWPVTVCKMSANDCQDPPEYWTIHGL WPDKGEECNRTWHFNVTEIKDLMSDMRRYWPDVIHSSLNRTQFWKHEWEKHGTCAATLPILDSQKKYFSK TLELYQLVNLNGFLLKAGIKPGSTYYQMAAIKEVLTEFYGITPKIQCLPPEEGEEAQTLGQIEFCFTKEL ELRNCTEPKGESSRMHTNLQRVTEELSVCNDTLPVYYPSQVKDRKWSLKSLKNFFN >XP_780287.3 ribonuclease Oy [Strongylocentrotus purpuratus] MNDFQITKMGIRVLVTAIIITLCLLNSRQISAWSVVELVSRLSSPKSPVAKQPSARDVQENAVFTNTRPAPGAAEVDKGK FIFDRLSLNKQSSNDTWTELILTIQWPQSFCLDYNDGRDYKEAGECKVPAGIDDWTIHGLWPSNPGKLGPENCNSTWKFD VTKISDLVAEMNASWPNCITDEAYDSLWSHEWDKHGTCASLLPALYGEHNYFQKTLTLRKQFDIKGMLEASAIVPSKTNS YDYPTIFNAVKGAIGTDPTVTCVYDHKTQLVYLSQVEICLDKQFNPVNCVGLNSMRKSSLGEESCANDKLIFYPLVN >XP_038078907.1 ribonuclease Oy-like [Patiria miniata] MCPRGASVFILAVVFVSMLSGTFSMPSFLSQRLCENCVQNEQTKSWDYLLFVNQWPETFCKYYNASHKHDNKDGQECIIP PIVSTWTIHGTWPTKTGTEGPTSCNNTWQFNLSQVKDLVPAMNKTWPGLLTGEEYWYFWSHEWDKHGTCAASLPVLYGEH NYFNKTLQLKQQHNIDKILSSSGIIPSSTVKYTRDKIEESVKNATGGMPDLICFQENSDSDFKQYLQEIRLCLDKSLKPF DCPKSKFMHLTSEYDSPCSSKTPIALPPLTTGNAAV >XP_031570988.1 ribonuclease Oy-like [Actinia tenebrosa] METKXVLLLLSFAIVLSISLGEEGFAKQSHDWKYFVFSQWWPQSQCYYKENADSLTDQSFRIVNDYRFRNDCVPNDVENW TIHGLWPTIDGSPNPGYCNKSWKFDSHEIEDLKSKMNRQWISLPDFSKSEHLWKHEWERHGTCAASLPAVSNEHAYFLKA LTLNLHTNLLNMLADKGLSPSDDKTYKVEEFEDAIMKEYGVKGRVICVKDRGDDQYIGGIRICFNKTFSPFECLVTKPEE CRKGKDLKYPVIIRA >CAE1331125.1 RNASET2 [Sepia pharaonis] MKVLLFVLLSVESILTRDIHFDYFVFTQQWPPAVCIEGQKTGHQCSIPTNVKGWVIHGLWPSRNMNRGPFFCNNSDTFDE NKLKPIEEELRLYWPNLFSDSPDLSFWKHEWKKHGTCSLSDKLIPDEFTYFKTALNLYKKYNITSILGNSGIIPNTYTSY KSDDFCNAVENSLNTVPVVTCIYDKISTHHYLLQIEICVDKDFNTIDCPERSSGHHSNKYTLYYKTKQDDSCARCSSNKG IWYPPITSYNVNHG >AAL25297.1 GH08338p [Drosophila melanogaster] MSVQDHNWDVLIFTQQWPVTTCYHWREENPDQECSLPQKKEFWTIHGIWPTKLHQMGPNFCNNSANFDPSKLNPIEDRLE TFWPDLKGMDSTEWLWKHEWQKHGTCAMLVEELDNELKYFEQGLTWREEYIMSRILDASDIHPDSNNTVAAINNAIVKAL GKNPSIHCLYDGKHGISYLSEIRICFSKSLELIDCDGIKQGDAVPVGVPGGTIITNCHIGSLVHYPSLVPPLQRKSHWKL PLVNVYKLLQFLMWFTL >NP_503370.1 Ribonuclease T2 protein rnst-2 [Caenorhabditis elegans] MKLLLLLCISCIPLAYSHDGEPFDYLMFTTIYPTAVCRADDDSVPESCEIPSGTPQWSIHGLWPNFENGSYPQNCRGTPR HFDENLIKSIEDRLVVVWPNLYPKKTIQSFWKHEYDKHGTCAQSEKLFESELAYFTEVMKVFDSIDVAGGLKSVGPSEKP ITSSDLKNALSGVTSGKTFQFHCLRDKKTKQFLLGDIRLCLNKDLTIRDCPTDGKHPNRVSRFERSIGRNRRGPPLPSFQ PCPAEFIYLPEMSSISKSSDSTSPSIFGRIWSAIKNIGN >XP_039248172.1 ribonuclease Oy-like [Styela clava] MRWIIFCGRMPLRTCMQTLLRVLFVLGFGGIFTIMQKNEVKWDYLVYTQIWPQSACIEINETIGDGKCVMPNNVKSWTIH GIWPDVHIGKNPSYCNDSWPFVPNDIKDIQPDLEIHWPNLILGDKVSAFWKHEWVKHGTCATSLPSLDSEHKYFQAGLNL RQKFDLSKMLSAAGIVPSLNTSIKLDRLRNVIKANTNSHTRLLCMETKTKTEQIIAQIEICLDKSFSPIDCDQSKYNLET PSTFQENPRFMRLKRSNTVWDPYPYFPNFMDCKDELPIKYLPIVPSLA >NP_001193266.1 ribonuclease T2 precursor [Bos taurus] MTSPAFLGALCLALSCLGGAHGFWRSDDLEWSKLIMVHHWPATVCQEVARHCKDPPNYWTIHGLWPDKSE ACNRSWPFNPHEIKDLLPDMKMYWPDLLHPSNSSLQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLYK ALALTSMLQKLGIEPSTDHYYQVSDIRDALVTVYKVVPKVQCFLLEKGQEVQLLGQVELCFSKDLQLQNC SHAAEPAARRQEAWPNLGLHVCNDGPVLYPPLNETKL >XP_043313021.1 ribonuclease T2 [Cervus canadensis] MTSPAFLGALCLALSCLGSARGLGRSDDLEWGKLIMVHHWPATVCQEVRGHCKDPPNYWTIHGLWPDKSEACNRSWPFNP QEIKDLLPDMKRYWPDLLHPSNCSLQFWSHEWKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTDHY YQVSDIRDALVSVYKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTHAGEPAARGQGAWPSLGLHVCEDGPVLYP PLDQTKL >NP_001086583.1 ribonuclease T2 L homeolog [Xenopus laevis] MVSYLRHSLAILVTLVAVHYGFTLRHHQEWKKLILTHHWPATVCEMDHGHCKNPPKYWTLHGLWPDKAQMCNNSWPFDSI QIKDILPEMNQYWPDLLHPNKSQLWKHEWQKHGTCAASLECLNTQLKYFSKGLEIYKQVDLNSVLEKSGIIPSTTYYQMK DIENALIGFYGVLPKIQCLPPHQGETAQTLGQIEICFTKEFQLRNCTESVDLNDPLIDWKAYNDDLHVCDNSTNTLYPPV KER >KAB0381136.1 hypothetical protein FD755_008920 [Muntiacus reevesi] MFSIWKVSVFTSQPFCPHLCVCQALPACDDLEWGKLIMVHHWPATVCQEVRGHCKDPPNYWTIHGLWPDKSEACNRSWPF NPQEIKVLTLARPPTHLACSREPGQTSPLGAWRGGHEERSCLWMWRWCSRGRASPCYLDKIKQRQSASRPDALHEGPSHE WKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTDRYYQVSDIRDALVSVYKVVPKVQCFLLEKGQEV QLLGQMELCFSKDLQLLNCTHAGEPAARGQGAWPRLGLHVCEDGPVLYPPLNQTKL >KAB0364565.1 hypothetical protein FD754_008721 [Muntiacus muntjak] MFSIWKVSVFTSQPFCPHLCVCQALPACDDLEWGKLIMVHHWPATVCQEVRGHCKDPPNYWTIHGLWPDKSEACNRSWPF NPQEIKVLTLARPPTHPACSREPGQTSPLGAWRGGHEERSCLWMWRWCSRGRASPCYLDKIKQRQSASRPDALHEGPSHE WKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTDRYYQVSDIRDALVSVYKVVPKVQCFLLEKGQEV QLLGQMELCFSKDLQLLNCTHAGEPAARRQGAWPRLGLHVCEDGPVLYPPLNQTKL >XP_015809255.1 PREDICTED: ribonuclease T2-like [Nothobranchius furzeri] MNLSSPLLFCLAAVFFSAASPHQIWNKLTLTHHWPTTFCSMEHCHAKISYWTLHGLWPDNGNECNSSWHFNSSQIEDLLP DMEKSWPDLIKPSSSSFWKYEWQKHGTCAAEAESLNSQHKYFSKALELYHKLDLSSALNKFNIIPSDYYKFSQIEGAIQS FYGVTPKIQCAHSSKNTQVQNLGQIEICFDSEFTLLDCEKNPNKEKFPEEVWNNLLVKTTSGFKVCDHDIPVYYPPLSLK >XP_023809297.1 ribonuclease T2 [Oryzias latipes] MRLHVLSLLALCACVSWAAVISPHHMWSKLILTHHWPNTFCSMEHCHPNISYWTLHGLWPDKGMDCNSSWHFNPSLIEDL LPDMNKSWPDLRNRSSVSFWKYEWHKHGTCAAKAESLNSQHKYFSKALELYHKLDLSSVLVKFGITPSDKYYPFSQVEGA IENVYGFKPKIQCVHSSKGGDFQSLGQIEICFDSDFTLMDCEKQSAKETFAKTGWDHFRGAKKASGFSVCDPDIPVYYPP LP >XP_030271242.1 ribonuclease T2-like isoform X1 [Sparus aurata] MRLYYPLLFCLAAALSSAYVISSPQMWTKLILTHHWPSTFCSMEHCHPNISYWTLHGLWPDKGIDCNASWHFNASEIEDL LPDMMKSWPDLLNPSSTGFWKYEWHKHGTCAARAASLNSEHKYFSKALELYHKVDLDSILKKFDITPSEKYYSFSQVEGA IENFYGVTPKIQCVHPKNAEFQILGQIEICFNSDFTLMDCERHFAREPISKGDNSTAVNKASGFLVCDHDTPVYYPPLKS HTSTY >KAF4024724.1 hypothetical protein G4228_016581 [Cervus hanglu yarkandensis] MVHHWPATVCQVSDIRDALVSMYKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTHAGEPAARGQGAWPSLGLHV CEDGPVLYPPLDQTKL >XP_005615626.1 ribonuclease T2 isoform X1 [Canis lupus familiaris] MRPAAPLRLLLSSLCLALCCPGGARGSRGSDNHEWKKLIMVHHWPVTVCKEVENDCRDPPDYWTIHGLWP DKAEECNGSWHFHLEEIKDLMPEMKMYWPDVIHPLNHSHFWKHEWEKHGTCAAQLDALNSQKKYFGGSLD LYRDLDLNSMLQKLGIKPSINYYQVSDIKDALAGIYGVIPKIQCLPPQQGEEVQTIGQIELCFTKELRLR NCTEPGEPGGPGGPAPRGPRAGVSGGTGLEVCEDGPAFYPPPPGAVP >XP_016812107.1 ribonuclease T2 isoform X1 [Pan troglodytes] MCPAALRGALLGCLYLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPDYWTIHGLWPD KSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSINYYQPFFQGLGSSGLEEGVYQPFPDSPSTPTPGSRKMIACRALTVLTWTH VRIDEGHVPAMFAQSLVFRELIPGVAKATGATHLLSCFQVRTALVWASETARWILGVLSFERSLIYHQEK FVAFASSIQPRIHSSVLWGNQGCGSTQESCRPRHFLGNALLRWRPAACPGPEGSGSVEQSWGLGAGRYGT SCLLRGLRGRAGGLGRGRVGAIDVRASSSSSAEL >NP_001077407.1 ribonuclease T2-A isoform 1 precursor [Mus musculus] MAPAEARGALPGWISVLGWGLALCSLCGAGPLWSGSHEWKKLILTQHWPPTVCKEVNSCQDSLDYWTIHG LWPDRAEDCNQSWHFNLDEIKDLLRDMKIYWPDVIHRSSNRSQFWKHEWVKHGTCAAQVDALNSEKKYFG KSLDLYKQIDLNSVLQKFGIKPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGESVQTVGQIELCFTKE DLHLRNCTEPGEQLSSRQEAWLAMEASTHGMMVCEDGPIFYPPPTKTQH >XP_001928120.2 ribonuclease T2 [Sus scrofa] MRLPAGLGVLCLALCCLGGARELWSGDHEWKKLIMVHHWPMTVCNEVANNCEHPPDYWTIHGLWPDKSGE CNRSWPFNPDEIKGLLPDMRLYWPDVLHSSPNHSVHFWRHEWEKHGTCAAQLDALNSQRKYFGKTLDLYK ELALNSTLQKLGIKPSISYYQISDIKHALVGVYGVVPKVQCLPPKSGEKVQTLGQIELCLTRDLQLQDCP EPGEPAPQRREAGPGGTPILGLEICEDGPVFYPPPKETNH >XP_002833012.2 ribonuclease T2 [Pongo abelii] MRPAALRGALLGCLYLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPDYWTIHGLWPD KSEGCNRSWPFNLEEIKDLLPEMKAYWPDVIHSFPNRSRFWKHEWEKHGTCAAQVDALSSQKKYFGRSLE LYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIPKIQCLPPSQDEEVQTIGQIELCLTKQDQQL QNCTEPGEQPSPKQEVWLANGAAESRGLRVCEDGPVFYPPPKKTKH >XP_003204111.2 ribonuclease T2 [Meleagris gallopavo] MKLAKLHYWILGCFSMASCCWCTSDKFPQSDGHSHTWKKLYLAHHWPVTVCKMSANDCQDPPDYWTIHGL WPDKGEECNRTWHFNVTEIKDLMSDMRRYWPDVIHSSLNRTHFWKHEWEKHGTCAASLPILDSQKKYFSE TLELYHHVDLNGFLLKAGIKPGSTYYQMADIKEVLTKFYGVTPKIQCLPPEESEKAQTLGQIEFCFTKEL KLRNCTEPKGESSQMHTNLQLVTEELSVCNDTLPVYYPSQVQDHKWSLKSLKNFNKTN >XP_003820272.1 ribonuclease T2 isoform X1 [Pan paniscus] MRPAALRGALLGCLYLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIHNDCRDPPDYWTIHGLWPD KSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIPKIQCLPPSQDEEVQTIGQIELCLTKQDQQL QNCTEPGEQPSPKQEVWLANGAAESRGLRVCEDGPVFYPPPKKTKP >XP_023110339.1 ribonuclease T2 [Felis catus] MKPAAARSLLLCALCLAMCRVGGASSDNHEWKKLIMVHHWPVTVCKEVGKDCRDPPDYWTIHGLWPDKAE ECNRSWHFNFQEIKDLLPEMKMYWPDVLHPLNHSHFWQHEWEKHGTCAAQVDTLNSQKRYFGGGLDLYQK LALNSMLQKLGIKPSINYYQISDIKDALASIYGVIPKVQCLPPESGEEVQTIGQIEVCFTKGLQLRNCTE AGEPEEPASRRPGAGGPGLEVCEDGPAFYPPPDETRKH >XP_027828458.1 ribonuclease T2 [Ovis aries] MTSPAFLGALCLALSCLGGAHGLWRSDDLEWSKLIMVHHWPATVCQEVESHCKDPPNYWTIHGLWPDKSE VCNRSWPFNPKEIKDLLPDMRRYWPDLLHPSNYSHQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLYK ALALTSMLQKLGIEPSTDHYYQVSDIRDALVSVYKVVPKVQCFLLEKGQEVQLLGQIELCFSKDLQLWNC SHAAEPAARRQEAWPNLGLHVCEDGPVLYPPLNETKL >XP_004044997.1 ribonuclease T2 isoform X1 [Gorilla gorilla gorilla] MRPAALRGALLGCLYLALLCLGGADKRLRDNHEWKKLIMVQHWPETVCEKIQNDCRDPPDYWTIHGLWPD KSEGCNRSWPFNLEEIKDLLPEMRAYWPDVIHSFPNRSRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSINYYQVADFKDALARVYGVIPKIQCLPPSQDEEVQTIGQIELCLTKQDQQL QNCTEPGEQPSPKQEVWLANGAAESRGLRVCEDGPVFYPPPKKTKH >XP_005508662.2 ribonuclease T2 [Columba livia] MKPVKLQYWILGWFSMALCCWCISDEFSQGDNQPHTWKKLFLAHHWPVTVCKMSANDCQDPPDYWTIHGL WPDKGEECNRTWHFNVTEIKDLMSDMRHYWPDVLHSSLNRTQFWKHEWDKHGTCATTLQALNSQKKYFGK ALELYKHIDLNSCLLKAGIKPSSSYYRMTDIKEALTKFYGVTPKIQCLLPEEGEKAQTIGQIEFCFTKEF QLRNCTTLKGESDPVQHAMKLGTKELSICSDTLPTYYPSEVQDHK >XP_017908952.1 PREDICTED: ribonuclease T2 [Capra hircus] MTSPAFLGALCLALSCLGGAHGLWRSDDLEWSKLIMVHHWPATVCQEVESHCKDPPNYWTIHGLWPDKSE VCNRSWPFNPKEIKDLLPDMRRYWPDLLHPSNYSHQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLFK ALALTSMLQKLGIEPSTDHYYQVSDIRDALVSVYKVVPKVQCFLLEKGQEVQLLGQIELCFSKDLQLWNC SHAAEPAARRQEAWPNLGLHVCEDGPVLYPPLNETKL >XP_006034588.1 ribonuclease T2 [Alligator sinensis] MNKMKPSLSHCLTLGYFLMFFYCGCTSAKCLERDCHPHTWDKLILVHHWPVTVCKMNMNDCDDPPQFWTI HGLWPDKGEDCNRTWHFNVNEIEDLLPDMKQYWPDILHSSLNSTRFWKHEWQKHGTCAAAIEPLNSQKKY FGKALDLYHKVDLNSYLLKVGIKPGHTHYQMSAIKEALTSFYGVTQKIQCIPPEEDEDVQTIGQIEFCFT KELELRNCTHSKTNSFLMQNNLKFRHEELSICNDTLTSYPLEV >XP_006261115.1 PREDICTED: ribonuclease T2 [Alligator mississippiensis] MNKMKPSISHCLTLGYFVMFFYCGCTSAKCLERDCHPHTWDKLILVHHWPVTVCKMNMNDCDDPPQFWTI HGLWPDKGEDCNRTWHFNVNEIEDLLPDMKQYWPDILHSSLNSTHFWKHEWQKHGTCAAAIEPLNSQKKY FGKALDLYHKVDLNSYLLKVGIKPGHTYYQMSAIKEALTSFYGVSPKIQCIPPEEDEDVQTIGQIEFCFT KELELRNCTHLKTNSFLMQNNLKFRHEELSICNDTLTSYPLEV >XP_008250933.1 PREDICTED: ribonuclease T2 [Oryctolagus cuniculus] MGPRAARPALLGGLCLALLLQAGAREPASGDHEWKKLILVQHWPATVCEEANDCREPPDYWTIHGLWPDK GGECNRSWHFNLDEIKDLLGEMKMYWPDVIHSSPNRTQFWKHEWEKHGTCAAQLEALNSQRKYFGTSLAL YKQLDLNSKLLKLGIKPSINYYHLADFKDALTRVYGVVPKIQCLPPEQDEQVQTIGQIELCYTKEDLHLR NCTEPGEPPPAKRGPWAAAARGLSVCESGPVFYPPPPKH >XP_020741611.1 ribonuclease T2 [Odocoileus virginianus texanus] MTSPAFLGALCLALSCLGSARGLGRSDDLEWGKLIMVHHWPATVCQEVRGHCKDPPSYWTIHGLWPDKSE ACNRSWPFNPQEIKDLLPDMKRYWPDLLHPSNCSLQFWSHEWKKHGTCAAQLDALNSQWKYFSKSLDLYK ELALSSVLQKLGIEPSIDRYYQVSDIRDALVSVYKVVPKVQCFLLEKGQELQLLGQMELCFSKDLQLLNC THAGEPAARGQGAWPRLGLHVCEDGPVLYPPLNQTKL >XP_040206575.1 ribonuclease T2 isoform X1 [Rana temporaria] MENSLRYILLVTCSLCAIHSSFVDNSLPTKNTPEWKKLILTHHWPVTVCKMAEQKCDDLPNYWTLHGLWT DKEQMCNKSWPFDFSEIKDILADMNKWWPDVLHPNCSQLWKHEWQKHGTCAASLPCLNTQHKYFSKGLEL YTRISLSSALEKSGIKPANTYKVEEIEDVILNVYGVIPKIQCIPPQQCRLYHNTKASGVESSDLWHIFKV QPLDYTQGEDAQTLGQIEICFTKDFDLRNCTVEPEDELSTKQMSRKLEASYVDLHVCDKSINTYYPPVQ
Mafft alignment of selected proteins >sp|B8XY56|RNT2_DANRE Ribonuclease T2 OS=Danio rerio OX=7955 GN=rnaset2 PE=2 SV=1 ---------MR--------FIAF-----AVIFSAVYLCSSA------------------- ------------------------------------------FTHPR---GEWTKLILTQ HWPQTFCK---------------------MEHCKTD--FSYWTLHGLWPNTG-----VRC NTS-WHFNASLIEDIL---------------------------PEMEKFW---------- ----------------PDLLEP--SSP-KFWNYEWTKHGTCAAKSESLNSEHKYFGKALE LYHKFDLNSVLLKNQIVPSEK-HYT-------LEDVEEAITSAY-GVKPKIQCVHPG--- ---------------------------QGGQV-QILGQIEICVDR-DFQLMGCEKSSEDT WSN---DLPTV------------PVS-GQSGLSVC------------------------- ---------------------------DHSM---------------------PVYYPPVQ A---------------------------------------------------- >sp|O00584|RNT2_HUMAN Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2 ---------MRPAALRGALLGCL-----CLALLCLGGA-DK------------------- ------------------------------------------RLRDN---HEWKKLIMVQ HWPETVCEKI-------------------QNDCRDP--PDYWTIHGLWPDKS-----EGC NRS-WPFNLEEIKDLL---------------------------PEMRAYW---------- ----------------PDVIHSFPNRS-RFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSIN-YYQ-------VADFKDALARVY-GVIPKIQCLPPS--- ---------------------------QDEEV-QTIGQIELCLTKQDQQLQNCTEPGEQP SPK---QEVWLAN----------GAA-ESRGLRVC------------------------- ---------------------------EDG----------------------PVFYPPPK KTKH------------------------------------------------- >NP_001099680.1 ribonuclease T2 precursor [Rattus norvegicus] ---------M--AEARGALPGWVSVLGWGLALCCLCGA-GP------------------- ------------------------------------------LWSGS---HEWKKLILTQ HWPPTVCKEV--------------------NRCRDS--LDYWTIHGLWPDRA-----EDC NHS-WHFNLNEIKDLL---------------------------RDMKIYW---------- ----------------PDVIHPSSNRS-QFWKHEWDKHGTCAAQVDALNSERKYFGKSLD LYKQIDLNSVLQKFEIKPSIN-YYQ-------LADFKDALTRIY-GVVPKIQCLMPE--- ---------------------------QGENV-QTIGQIELCFTKEDFHLRNCTEPEEQP SSG---QEARLAR-----------EA-STHGMMVC------------------------- ---------------------------EDG----------------------PIFYPPPK SQH-------------------------------------------------- >NP_001034580.1 ribonuclease T2 precursor [Gallus gallus] ---------MKPAKLHYWILGCF-----SIVSCCWCTS-DQ------------------- ------------------------------------------FPQSDSHPHTWKKLYLAH HWPVTVCKMS-------------------ANDCQDP--PEYWTIHGLWPDKG-----EEC NRT-WHFNVTEIKDLM---------------------------SDMRRYW---------- ----------------PDVIHSSLNRT-QFWKHEWEKHGTCAATLPILDSQKKYFSKTLE LYQLVNLNGFLLKAGIKPGST-YYQ-------MAAIKEVLTEFY-GITPKIQCLPPE--- ---------------------------EGEEA-QTLGQIEFCFTK-ELELRNCTEPKGES SRM---HTNL--------------QR-VTEELSVC------------------------- ---------------------------NDTL---------------------PVYYPSQV KDRK----WSLKS---------LKNF-------------------------FN >XP_780287.3 ribonuclease Oy [Strongylocentrotus purpuratus] ---------MNDFQITKMGIRVLVTA--IIITLCLLNSRQISAWSVVELVSRLSSPKSPV AKQPSARDVQENAVFTNTRPAPGAAEVDKGKFIFDRLSLN--KQSSN---DTWTELILTI QWPQSFCLDYNDG-----------RDYKEAGECKVPAGIDDWTIHGLWPSNPGKLGPENC NST-WKFDVTKISDLV---------------------------AEMNASW---------- ----------------PNCITDE-AYD-SLWSHEWDKHGTCASLLPALYGEHNYFQKTLT LRKQFDIKGMLEASAIVPSKTNSYD-------YPTIFNAVKGAI-GTDPTVTCVYDH--- ---------------------------KTQLV--YLSQVEICLDK-QFNPVNCVGLNSMR KSS--------------------------LGEESC------------------------- ---------------------------ANDK---------------------LIFYPLVN ----------------------------------------------------- >XP_038078907.1 ribonuclease Oy-like [Patiria miniata] ---------MCPRGASVFILAVV-----FVSMLSGTFSMPS------------------- -------------------------------FLSQRLCENCVQNEQT---KSWDYLLFVN QWPETFCKYYNASHK---------HDNKDGQECIIPPIVSTWTIHGTWPTKTGTEGPTSC NNT-WQFNLSQVKDLV---------------------------PAMNKTW---------- ----------------PGLLTGE-EYW-YFWSHEWDKHGTCAASLPVLYGEHNYFNKTLQ LKQQHNIDKILSSSGIIPSSTVKYT-------RDKIEESVKNAT-GGMPDLICFQEN--- ---------------------------SDSDFKQYLQEIRLCLDK-SLKPFDCPKSKFMH LTS--------------------------EYDSPC------------------------- ---------------------------SSKT---------------------PIALPPLT TGNA-----------------------------------------------AV >XP_031570988.1 ribonuclease Oy-like [Actinia tenebrosa] ---------ME---TKXVLLLLS-----FAIVLSISLGEEG------------------- ------------------------------------------FAKQS---HDWKYFVFSQ WWPQSQCYYKENADSLTDQSFRIVNDYRFRNDC-VPNDVENWTIHGLWPTIDGSPNPGYC NKS-WKFDSHEIEDLK---------------------------SKMNRQW---------- ----------------ISLPDFS-KSE-HLWKHEWERHGTCAASLPAVSNEHAYFLKALT LNLHTNLLNMLADKGLSPSDDKTYK-------VEEFEDAIMKEY-GVKGRVICVKDR--- ---------------------------GDD---QYIGGIRICFNK-TFSPFECLVTKPEE ----------------------------------C------------------------- ---------------------------RKGK---------------------DLKYPVII RA--------------------------------------------------- >CAE1331125.1 RNASET2 [Sepia pharaonis] ---------MK-------------------VLLFVLLSVES------------------- ------------------------------------------ILTRD---IHFDYFVFTQ QWPPAVCIEGQKT----------------GHQCSIPTNVKGWVIHGLWPSRNMNRGPFFC NNS-DTFDENKLKPIE---------------------------EELRLYW---------- ----------------PNLFSDS-PDL-SFWKHEWKKHGTCSLSDKLIPDEFTYFKTALN LYKKYNITSILGNSGIIPNTYTSYK-------SDDFCNAVENSL-NTVPVVTCIYDK--- ---------------------------ISTH--HYLLQIEICVDK-DFNTIDCPERSSGH HSN---KYTLYY-----------KTK-QDDSCARC------------------------- ---------------------------SSNK---------------------GIWYPPIT SYNVN----------------------------------------------HG >AAL25297.1 GH08338p [Drosophila melanogaster] ------------------------------------------------------------ ------------------------------------------MSVQD---HNWDVLIFTQ QWPVTTCYHWREENP--------------DQECSLPQKKEFWTIHGIWPTKLHQMGPNFC NNS-ANFDPSKLNPIE---------------------------DRLETFW---------- ----------------PDLKGMD-STE-WLWKHEWQKHGTCAMLVEELDNELKYFEQGLT WREEYIMSRILDASDIHPDSNNT---------VAAINNAIVKAL-GKNPSIHCLYDG--- ---------------------------KHGI--SYLSEIRICFSK-SLELIDCDGIKQGD AVP-------------------VGVP-GGTIITNC------------------------- ---------------------------HIGS---------------------LVHYPSLV PPLQRKSHWKLPL-VNVYK--LLQFLMW----------------------FTL >NP_503370.1 Ribonuclease T2 protein rnst-2 [Caenorhabditis elegans] ---------MK-----------------LLLLLCISCIPLA------------------- ------------------------------------------YSHDG---EPFDYLMFTT IYPTAVCRADDDSV---------------PESCEIPSGTPQWSIHGLWPNFENGSYPQNC RGTPRHFDENLIKSIE---------------------------DRLVVVW---------- ----------------PNLYPKK-TIQ-SFWKHEYDKHGTCAQSEKLFESELAYFTEVMK VFDSIDVAGGLKSVG--PSEK-PIT-------SSDLKNALSGVTSGKTFQFHCLRDK--- ---------------------------KTKQF--LLGDIRLCLNK-DLTIRDCPTDGKHP NRVSRFERSIGRNR---------RGP-PLPSFQPC------------------------- ---------------------------PAEF----------------------IYLPEMS SISKSSDSTSPSIFGRIWS--AIKNI-------------------------GN >XP_039248172.1 ribonuclease Oy-like [Styela clava] MRWIIFCGRMPLRTCMQTLLR-------VLFVLGFGGIFTI------------------- ------------------------------------------MQKNE---VKWDYLVYTQ IWPQSACIEINETIG--------------DGKCVMPNNVKSWTIHGIWPDVHIGKNPSYC NDS-WPFVPNDIKDIQ---------------------------PDLEIHW---------- ----------------PNLILGD-KVS-AFWKHEWVKHGTCATSLPSLDSEHKYFQAGLN LRQKFDLSKMLSAAGIVPSLNTSIK-------LDRLRNVIKANT-NSHTRLLCMETK--- ---------------------------TKTE--QIIAQIEICLDK-SFSPIDCDQSKYNL ETPSTFQENPRFMRLKRSNTVWDPYP-YFPNFMDC------------------------- ---------------------------KDEL---------------------PIKYLPIV PSLA------------------------------------------------- >NP_001193266.1 ribonuclease T2 precursor [Bos taurus] -------------MTSPAFLGAL-----CLALSCLGGAHGF------------------- ------------------------------------------WRSDD---LEWSKLIMVH HWPATVCQEV-------------------ARHCKDP--PNYWTIHGLWPDKS-----EAC NRS-WPFNPHEIKDLL---------------------------PDMKMYW---------- ----------------PDLLHPSNSSL-QFWSHEWKKHGTCAAQLDALNSQRKYFGKSLD LYKALALTSMLQKLGIEPSTDHYYQ-------VSDIRDALVTVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQVELCFSK-DLQLQNCSHAAEPA ARR---QEAW-----------------PNLGLHVC------------------------- ---------------------------NDG----------------------PVLYPPLN ETKL------------------------------------------------- >XP_043313021.1 ribonuclease T2 [Cervus canadensis] -------------MTSPAFLGAL-----CLALSCLGSARGL------------------- ------------------------------------------GRSDD---LEWGKLIMVH HWPATVCQEV-------------------RGHCKDP--PNYWTIHGLWPDKS-----EAC NRS-WPFNPQEIKDLL---------------------------PDMKRYW---------- ----------------PDLLHPSNCSL-QFWSHEWKKHGTCAAQLDALNSQWKYFSKSLD LYKELALSSVLQKLGIEPSTDHYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQMELCFSK-DLQLLNCTHAGEPA ARG---QGAW-----------------PSLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLD QTKL------------------------------------------------- >NP_001086583.1 ribonuclease T2 L homeolog [Xenopus laevis] ---------MV-SYLRHSLAILV-----TLVAVHYGFT---------------------- -------------------------------------------LRHH---QEWKKLILTH HWPATVCEMD-------------------HGHCKNP--PKYWTLHGLWPDKA-----QMC NNS-WPFDSIQIKDIL---------------------------PEMNQYW---------- ----------------PDLLHP--NKS-QLWKHEWQKHGTCAASLECLNTQLKYFSKGLE IYKQVDLNSVLEKSGIIPSTT-YYQ-------MKDIENALIGFY-GVLPKIQCLPPH--- ---------------------------QGETA-QTLGQIEICFTK-EFQLRNCTESVDLN DPL------------------IDWKA-YNDDLHVC------------------------- ---------------------------DNST---------------------NTLYPPVK ER--------------------------------------------------- >KAB0381136.1 hypothetical protein FD755_008920 [Muntiacus reevesi] MFSIW----KVSVFTSQPFCPHL-----CV-------CQAL------------------- ------------------------------------------PACDD---LEWGKLIMVH HWPATVCQEV-------------------RGHCKDP--PNYWTIHGLWPDKS-----EAC NRS-WPFNPQEIKVLTLARPPTHLACSREPGQTSPLGAWRGGHEERSCLWMWRWCSRGRA SPCYLDKIKQRQSASRPDALHEGP-------SHEWKKHGTCAAQLDALNSQWKYFSKSLD LYKELALSSVLQKLGIEPSTDRYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQMELCFSK-DLQLLNCTHAGEPA ARG---QGAW-----------------PRLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLN QTKL------------------------------------------------- >KAB0364565.1 hypothetical protein FD754_008721 [Muntiacus muntjak] MFSIW----KVSVFTSQPFCPHL-----CV-------CQAL------------------- ------------------------------------------PACDD---LEWGKLIMVH HWPATVCQEV-------------------RGHCKDP--PNYWTIHGLWPDKS-----EAC NRS-WPFNPQEIKVLTLARPPTHPACSREPGQTSPLGAWRGGHEERSCLWMWRWCSRGRA SPCYLDKIKQRQSASRPDALHEGP-------SHEWKKHGTCAAQLDALNSQWKYFSKSLD LYKELALSSVLQKLGIEPSTDRYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQMELCFSK-DLQLLNCTHAGEPA ARR---QGAW-----------------PRLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLN QTKL------------------------------------------------- >XP_015809255.1 PREDICTED: ribonuclease T2-like [Nothobranchius furzeri] ---------MN--------LS-------SPLLFCLAAVFFS------------------- ------------------------------------------AASPH---QIWNKLTLTH HWPTTFCS---------------------MEHCHAK--ISYWTLHGLWPDNG-----NEC NSS-WHFNSSQIEDLL---------------------------PDMEKSW---------- ----------------PDLIKP--SSS-SFWKYEWQKHGTCAAEAESLNSQHKYFSKALE LYHKLDLSSALNKFNIIPSD--YYK-------FSQIEGAIQSFY-GVTPKIQCAHSS--- ---------------------------KNTQV-QNLGQIEICFDS-EFTLLDCEKNPNKE KFP---EEVWNNL----------LVK-TTSGFKVC------------------------- ---------------------------DHDI---------------------PVYYPPLS LK--------------------------------------------------- >XP_023809297.1 ribonuclease T2 [Oryzias latipes] ---------MR--------LHVL-----SLLALCACVSWAA------------------- ------------------------------------------VISPH---HMWSKLILTH HWPNTFCS---------------------MEHCHPN--ISYWTLHGLWPDKG-----MDC NSS-WHFNPSLIEDLL---------------------------PDMNKSW---------- ----------------PDLRNR--SSV-SFWKYEWHKHGTCAAKAESLNSQHKYFSKALE LYHKLDLSSVLVKFGITPSDK-YYP-------FSQVEGAIENVY-GFKPKIQCVHSS--- ---------------------------KGGDF-QSLGQIEICFDS-DFTLMDCEKQSAKE TFA---KTGWDHFR---------GAK-KASGFSVC------------------------- ---------------------------DPDI---------------------PVYYPPLP ----------------------------------------------------- >XP_030271242.1 ribonuclease T2-like isoform X1 [Sparus aurata] ---------MR--------LYYP-----LLFCLAAALSSAY------------------- ------------------------------------------VISSP---QMWTKLILTH HWPSTFCS---------------------MEHCHPN--ISYWTLHGLWPDKG-----IDC NAS-WHFNASEIEDLL---------------------------PDMMKSW---------- ----------------PDLLNP--SST-GFWKYEWHKHGTCAARAASLNSEHKYFSKALE LYHKVDLDSILKKFDITPSEK-YYS-------FSQVEGAIENFY-GVTPKIQCVHP---- ---------------------------KNAEF-QILGQIEICFNS-DFTLMDCERHFARE PIS---KGDNST-----------AVN-KASGFLVC------------------------- ---------------------------DHDT---------------------PVYYPPLK SHTS-----------------------------------------------TY >KAF4024724.1 hypothetical protein G4228_016581 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ---------------------------------------------------------MVH HWPATVC----------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------Q-------VSDIRDALVSMY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQMELCFSK-DLQLLNCTHAGEPA ARG---QGAW-----------------PSLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLD QTKL------------------------------------------------- >XP_005615626.1 ribonuclease T2 isoform X1 [Canis lupus familiaris] ---------MRPAAPLRLLLSSL-----CLALCCPGGARGS------------------- ------------------------------------------RGSDN---HEWKKLIMVH HWPVTVCKEV-------------------ENDCRDP--PDYWTIHGLWPDKA-----EEC NGS-WHFHLEEIKDLM---------------------------PEMKMYW---------- ----------------PDVIHPL-NHS-HFWKHEWEKHGTCAAQLDALNSQKKYFGGSLD LYRDLDLNSMLQKLGIKPSIN-YYQ-------VSDIKDALAGIY-GVIPKIQCLPPQ--- ---------------------------QGEEV-QTIGQIELCFTK-ELRLRNCTEPGEPG GPG---GPAPRGPR--------AGVS-GGTGLEVC------------------------- ---------------------------EDG----------------------PAFYPPPP GAVP------------------------------------------------- >XP_016812107.1 ribonuclease T2 isoform X1 [Pan troglodytes] ---------MCPAALRGALLGCL-----YLALLCLGGA-DK------------------- ------------------------------------------RLRDN---HEWKKLIMVQ HWPETVCEKI-------------------QNDCRDP--PDYWTIHGLWPDKS-----EGC NRS-WPFNLEEIKDLL---------------------------PEMRAYW---------- ----------------PDVIHSFPNRS-RFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSIN-YYQPFFQGLGSSGLEE---GVY-QPFPDSPSTPTP--- ---------------------------GSRKM-IACRALTVLTWT-HVRIDEGHVPAMFA QSL-VFRELIPGV----------AKATGATHLLSCFQVRTALVWASETARWILGVLSFER SLIYHQEKFVAFASSIQPRIHSSVLWGNQGCGSTQESCRPRHFLGNALLRWRPAACPGPE GSGSVEQSWGLGA-GRYGTSCLLRGLRGRAGGLGRGRVGAIDVRASSSSSAEL >NP_001077407.1 ribonuclease T2-A isoform 1 precursor [Mus musculus] ---------MAPAEARGALPGWISVLGWGLALCSLCGA-GP------------------- ------------------------------------------LWSGS---HEWKKLILTQ HWPPTVCKEV--------------------NSCQDS--LDYWTIHGLWPDRA-----EDC NQS-WHFNLDEIKDLL---------------------------RDMKIYW---------- ----------------PDVIHRSSNRS-QFWKHEWVKHGTCAAQVDALNSEKKYFGKSLD LYKQIDLNSVLQKFGIKPSIN-YYQ-------LADFKDALTRIY-GVVPKIQCLMPE--- ---------------------------QGESV-QTVGQIELCFTKEDLHLRNCTEPGEQL SSR---QEAWLAM-----------EA-STHGMMVC------------------------- ---------------------------EDG----------------------PIFYPPPT KTQH------------------------------------------------- >XP_001928120.2 ribonuclease T2 [Sus scrofa] ---------MR----LPAGLGVL-----CLALCCLGGA-RE------------------- ------------------------------------------LWSGD---HEWKKLIMVH HWPMTVCNEV-------------------ANNCEHP--PDYWTIHGLWPDKS-----GEC NRS-WPFNPDEIKGLL---------------------------PDMRLYW---------- ----------------PDVLHSSPNHSVHFWRHEWEKHGTCAAQLDALNSQRKYFGKTLD LYKELALNSTLQKLGIKPSIS-YYQ-------ISDIKHALVGVY-GVVPKVQCLPPK--- ---------------------------SGEKV-QTLGQIELCLTR-DLQLQDCPEPGEPA PQR---REAGP------------GGT-PILGLEIC------------------------- ---------------------------EDG----------------------PVFYPPPK ETNH------------------------------------------------- >XP_002833012.2 ribonuclease T2 [Pongo abelii] ---------MRPAALRGALLGCL-----YLALLCLGGA-DK------------------- ------------------------------------------RLRDN---HEWKKLIMVQ HWPETVCEKI-------------------QNDCRDP--PDYWTIHGLWPDKS-----EGC NRS-WPFNLEEIKDLL---------------------------PEMKAYW---------- ----------------PDVIHSFPNRS-RFWKHEWEKHGTCAAQVDALSSQKKYFGRSLE LYRELDLNSVLLKLGIKPSIN-YYQ-------VADFKDALARVY-GVIPKIQCLPPS--- ---------------------------QDEEV-QTIGQIELCLTKQDQQLQNCTEPGEQP SPK---QEVWLAN----------GAA-ESRGLRVC------------------------- ---------------------------EDG----------------------PVFYPPPK KTKH------------------------------------------------- >XP_003204111.2 ribonuclease T2 [Meleagris gallopavo] ---------MKLAKLHYWILGCF-----SMASCCWCTS-DK------------------- ------------------------------------------FPQSDGHSHTWKKLYLAH HWPVTVCKMS-------------------ANDCQDP--PDYWTIHGLWPDKG-----EEC NRT-WHFNVTEIKDLM---------------------------SDMRRYW---------- ----------------PDVIHSSLNRT-HFWKHEWEKHGTCAASLPILDSQKKYFSETLE LYHHVDLNGFLLKAGIKPGST-YYQ-------MADIKEVLTKFY-GVTPKIQCLPPE--- ---------------------------ESEKA-QTLGQIEFCFTK-ELKLRNCTEPKGES SQM---HTNL--------------QL-VTEELSVC------------------------- ---------------------------NDTL---------------------PVYYPSQV QDHK----WSLKS---------LKNFN-----------------------KTN >XP_003820272.1 ribonuclease T2 isoform X1 [Pan paniscus] ---------MRPAALRGALLGCL-----YLALLCLGGA-DK------------------- ------------------------------------------RLRDN---HEWKKLIMVQ HWPETVCEKI-------------------HNDCRDP--PDYWTIHGLWPDKS-----EGC NRS-WPFNLEEIKDLL---------------------------PEMRAYW---------- ----------------PDVIHSFPNRS-RFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSIN-YYQ-------VADFKDALARVY-GVIPKIQCLPPS--- ---------------------------QDEEV-QTIGQIELCLTKQDQQLQNCTEPGEQP SPK---QEVWLAN----------GAA-ESRGLRVC------------------------- ---------------------------EDG----------------------PVFYPPPK KTKP------------------------------------------------- >XP_023110339.1 ribonuclease T2 [Felis catus] ---------MKPAAARSLLLCAL-----CLAMCRVGGA---------------------- -------------------------------------------SSDN---HEWKKLIMVH HWPVTVCKEV-------------------GKDCRDP--PDYWTIHGLWPDKA-----EEC NRS-WHFNFQEIKDLL---------------------------PEMKMYW---------- ----------------PDVLHPL-NHS-HFWQHEWEKHGTCAAQVDTLNSQKRYFGGGLD LYQKLALNSMLQKLGIKPSIN-YYQ-------ISDIKDALASIY-GVIPKVQCLPPE--- ---------------------------SGEEV-QTIGQIEVCFTK-GLQLRNCTEAGEPE EPA---SRRP--------------GA-GGPGLEVC------------------------- ---------------------------EDG----------------------PAFYPPPD ETRKH------------------------------------------------ >XP_027828458.1 ribonuclease T2 [Ovis aries] -------------MTSPAFLGAL-----CLALSCLGGAHGL------------------- ------------------------------------------WRSDD---LEWSKLIMVH HWPATVCQEV-------------------ESHCKDP--PNYWTIHGLWPDKS-----EVC NRS-WPFNPKEIKDLL---------------------------PDMRRYW---------- ----------------PDLLHPSNYSH-QFWSHEWKKHGTCAAQLDALNSQRKYFGKSLD LYKALALTSMLQKLGIEPSTDHYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQIELCFSK-DLQLWNCSHAAEPA ARR---QEAW-----------------PNLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLN ETKL------------------------------------------------- >XP_004044997.1 ribonuclease T2 isoform X1 [Gorilla gorilla gorilla] ---------MRPAALRGALLGCL-----YLALLCLGGA-DK------------------- ------------------------------------------RLRDN---HEWKKLIMVQ HWPETVCEKI-------------------QNDCRDP--PDYWTIHGLWPDKS-----EGC NRS-WPFNLEEIKDLL---------------------------PEMRAYW---------- ----------------PDVIHSFPNRS-RFWKHEWEKHGTCAAQVDALNSQKKYFGRSLE LYRELDLNSVLLKLGIKPSIN-YYQ-------VADFKDALARVY-GVIPKIQCLPPS--- ---------------------------QDEEV-QTIGQIELCLTKQDQQLQNCTEPGEQP SPK---QEVWLAN----------GAA-ESRGLRVC------------------------- ---------------------------EDG----------------------PVFYPPPK KTKH------------------------------------------------- >XP_005508662.2 ribonuclease T2 [Columba livia] ---------MKPVKLQYWILGWF-----SMALCCWCIS-DE------------------- ------------------------------------------FSQGDNQPHTWKKLFLAH HWPVTVCKMS-------------------ANDCQDP--PDYWTIHGLWPDKG-----EEC NRT-WHFNVTEIKDLM---------------------------SDMRHYW---------- ----------------PDVLHSSLNRT-QFWKHEWDKHGTCATTLQALNSQKKYFGKALE LYKHIDLNSCLLKAGIKPSSS-YYR-------MTDIKEALTKFY-GVTPKIQCLLPE--- ---------------------------EGEKA-QTIGQIEFCFTK-EFQLRNCTTLKGES DPV---QHAM--------------KL-GTKELSIC------------------------- ---------------------------SDTL---------------------PTYYPSEV QDHK------------------------------------------------- >XP_017908952.1 PREDICTED: ribonuclease T2 [Capra hircus] -------------MTSPAFLGAL-----CLALSCLGGAHGL------------------- ------------------------------------------WRSDD---LEWSKLIMVH HWPATVCQEV-------------------ESHCKDP--PNYWTIHGLWPDKS-----EVC NRS-WPFNPKEIKDLL---------------------------PDMRRYW---------- ----------------PDLLHPSNYSH-QFWSHEWKKHGTCAAQLDALNSQRKYFGKSLD LFKALALTSMLQKLGIEPSTDHYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEV-QLLGQIELCFSK-DLQLWNCSHAAEPA ARR---QEAW-----------------PNLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLN ETKL------------------------------------------------- >XP_006034588.1 ribonuclease T2 [Alligator sinensis] MNK------MKPSLSHCLTLGYF-----LMFFYCGCTS-AK------------------- ------------------------------------------CLERDCHPHTWDKLILVH HWPVTVCKMN-------------------MNDCDDP--PQFWTIHGLWPDKG-----EDC NRT-WHFNVNEIEDLL---------------------------PDMKQYW---------- ----------------PDILHSSLNST-RFWKHEWQKHGTCAAAIEPLNSQKKYFGKALD LYHKVDLNSYLLKVGIKPGHT-HYQ-------MSAIKEALTSFY-GVTQKIQCIPPE--- ---------------------------EDEDV-QTIGQIEFCFTK-ELELRNCTHSKTNS FLM---QNNL--------------KF-RHEELSIC------------------------- ---------------------------NDTL----------------------TSYPLEV ----------------------------------------------------- >XP_006261115.1 PREDICTED: ribonuclease T2 [Alligator mississippiensis] MNK------MKPSISHCLTLGYF-----VMFFYCGCTS-AK------------------- ------------------------------------------CLERDCHPHTWDKLILVH HWPVTVCKMN-------------------MNDCDDP--PQFWTIHGLWPDKG-----EDC NRT-WHFNVNEIEDLL---------------------------PDMKQYW---------- ----------------PDILHSSLNST-HFWKHEWQKHGTCAAAIEPLNSQKKYFGKALD LYHKVDLNSYLLKVGIKPGHT-YYQ-------MSAIKEALTSFY-GVSPKIQCIPPE--- ---------------------------EDEDV-QTIGQIEFCFTK-ELELRNCTHLKTNS FLM---QNNL--------------KF-RHEELSIC------------------------- ---------------------------NDTL----------------------TSYPLEV ----------------------------------------------------- >XP_008250933.1 PREDICTED: ribonuclease T2 [Oryctolagus cuniculus] ---------MGPRAARPALLGGL-----CLALLLQAGA-RE------------------- ------------------------------------------PASGD---HEWKKLILVQ HWPATVCEE--------------------ANDCREP--PDYWTIHGLWPDKG-----GEC NRS-WHFNLDEIKDLL---------------------------GEMKMYW---------- ----------------PDVIHSSPNRT-QFWKHEWEKHGTCAAQLEALNSQRKYFGTSLA LYKQLDLNSKLLKLGIKPSIN-YYH-------LADFKDALTRVY-GVVPKIQCLPPE--- ---------------------------QDEQV-QTIGQIELCYTKEDLHLRNCTEPGEPP PAK---RGPW--------------AA-AARGLSVC------------------------- ---------------------------ESG----------------------PVFYPPPP KH--------------------------------------------------- >XP_020741611.1 ribonuclease T2 [Odocoileus virginianus texanus] -------------MTSPAFLGAL-----CLALSCLGSARGL------------------- ------------------------------------------GRSDD---LEWGKLIMVH HWPATVCQEV-------------------RGHCKDP--PSYWTIHGLWPDKS-----EAC NRS-WPFNPQEIKDLL---------------------------PDMKRYW---------- ----------------PDLLHPSNCSL-QFWSHEWKKHGTCAAQLDALNSQWKYFSKSLD LYKELALSSVLQKLGIEPSIDRYYQ-------VSDIRDALVSVY-KVVPKVQCFLLE--- ---------------------------KGQEL-QLLGQMELCFSK-DLQLLNCTHAGEPA ARG---QGAW-----------------PRLGLHVC------------------------- ---------------------------EDG----------------------PVLYPPLN QTKL------------------------------------------------- >XP_040206575.1 ribonuclease T2 isoform X1 [Rana temporaria] ---------ME-NSLRYILLVTC-----SLCAIHSSFVDNS------------------- -----------------------------------------LPTKNT---PEWKKLILTH HWPVTVCKMA-------------------EQKCDDL--PNYWTLHGLWTDKE-----QMC NKS-WPFDFSEIKDIL---------------------------ADMNKWW---------- ----------------PDVLHP--NCS-QLWKHEWQKHGTCAASLPCLNTQHKYFSKGLE LYTRISLSSALEKSGIKPANT--YK-------VEEIEDVILNVY-GVIPKIQCIPPQQCR LYHNTKASGVESSDLWHIFKVQPLDYTQGEDA-QTLGQIEICFTK-DFDLRNCTVEPEDE LST---KQMSRK-----------LEA-SYVDLHVC------------------------- ---------------------------DKSI---------------------NTYYPPVQ -----------------------------------------------------
BMGE Cleaned alignment of selected proteins >sp|B8XY56|RNT2_DANRE Ribonuclease T2 OS=Danio rerio OX=7955 GN=rnaset2 PE=2 SV=1 --FIAFAVIFSAVYLCGEWTKLILTQHWPQTFCKHCKTDFSYWTLHGLWPNTGRCNTSWHFNASLIEDILPDLLEKFWNYEWTKHGTCAAKSESLNSEHKYFGKALELYHKFDLNSVLLKNQIVPSELEDVEEAITGVKPKIQCVHPGQGGQVQILGQIEICVDRDFQLMGCEGLSVCPVYYPPV >sp|O00584|RNT2_HUMAN Ribonuclease T2 OS=Homo sapiens OX=9606 GN=RNASET2 PE=1 SV=2 ALLGCLCLALLCLGGAHEWKKLIMVQHWPETVCEDCRDPPDYWTIHGLWPDKSGCNRSWPFNLEEIKDLLPDVIHRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSIVADFKDALAGVIPKIQCLPPSQDEEVQTIGQIELCLTKDQQLQNCTGLRVCPVFYPPP >NP_001099680.1 ribonuclease T2 precursor [Rattus norvegicus] ALPGWVGLALCCLCGAHEWKKLILTQHWPPTVCKRCRDSLDYWTIHGLWPDRADCNHSWHFNLNEIKDLLPDVIHQFWKHEWDKHGTCAAQVDALNSERKYFGKSLDLYKQIDLNSVLQKFEIKPSILADFKDALTGVVPKIQCLMPEQGENVQTIGQIELCFTKDFHLRNCTGMMVCPIFYPPP >NP_001034580.1 ribonuclease T2 precursor [Gallus gallus] WILGCFSIVSCCWCTSHTWKKLYLAHHWPVTVCKDCQDPPEYWTIHGLWPDKGECNRTWHFNVTEIKDLMPDVIHQFWKHEWEKHGTCAATLPILDSQKKYFSKTLELYQLVNLNGFLLKAGIKPGSMAAIKEVLTGITPKIQCLPPEEGEEAQTLGQIEFCFTKELELRNCTELSVCPVYYPSQ >XP_780287.3 ribonuclease Oy [Strongylocentrotus purpuratus] MGIRVLIIITLCLLNSDTWTELILTIQWPQSFCLECKVPIDDWTIHGLWPSNPNCNSTWKFDVTKISDLVPNCITSLWSHEWDKHGTCASLLPALYGEHNYFQKTLTLRKQFDIKGMLEASAIVPSKYPTIFNAVKGTDPTVTCVYDHKTQLV-YLSQVEICLDKQFNPVNCVGEESCLIFYPLV >XP_038078907.1 ribonuclease Oy-like [Patiria miniata] FILAVVFVSMLSGTFSKSWDYLLFVNQWPETFCKECIIPVSTWTIHGTWPTKTSCNNTWQFNLSQVKDLVPGLLTYFWSHEWDKHGTCAASLPVLYGEHNYFNKTLQLKQQHNIDKILSSSGIIPSSRDKIEESVKGGMPDLICFQENSDSDFQYLQEIRLCLDKSLKPFDCPYDSPCPIALPPL >XP_031570988.1 ribonuclease Oy-like [Actinia tenebrosa] VLLLLSFAIVLSISLGHDWKYFVFSQWWPQSQCYDC-VPVENWTIHGLWPTIDYCNKSWKFDSHEIEDLKISLPDHLWKHEWERHGTCAASLPAVSNEHAYFLKALTLNLHTNLLNMLADKGLSPSDVEEFEDAIMGVKGRVICVKDRGDD--QYIGGIRICFNKTFSPFECL----CDLKYPVI >CAE1331125.1 RNASET2 [Sepia pharaonis] --------VLLFVLLSIHFDYFVFTQQWPPAVCIQCSIPVKGWVIHGLWPSRNFCNNSDTFDENKLKPIEPNLFSSFWKHEWKKHGTCSLSDKLIPDEFTYFKTALNLYKKYNITSILGNSGIIPNTSDDFCNAVENTVPVVTCIYDKISTH-HYLLQIEICVDKDFNTIDCPSCARCGIWYPPI >AAL25297.1 GH08338p [Drosophila melanogaster] ----------------HNWDVLIFTQQWPVTTCYECSLPKEFWTIHGIWPTKLFCNNSANFDPSKLNPIEPDLKGWLWKHEWQKHGTCAMLVEELDNELKYFEQGLTWREEYIMSRILDASDIHPDSVAAINNAIVGKNPSIHCLYDGKHGI-SYLSEIRICFSKSLELIDCDIITNCLVHYPSL >NP_503370.1 Ribonuclease T2 protein rnst-2 [Caenorhabditis elegans] ------LLLLLCISCIEPFDYLMFTTIYPTAVCRSCEIPTPQWSIHGLWPNFENCRGTRHFDENLIKSIEPNLYPSFWKHEYDKHGTCAQSEKLFESELAYFTEVMKVFDSIDVAGGLKSVG--PSESSDLKNALSGKTFQFHCLRDKKTKQF-LLGDIRLCLNKDLTIRDCPSFQPC-IYLPEM >XP_039248172.1 ribonuclease Oy-like [Styela clava] TLLR--VLFVLGFGGIVKWDYLVYTQIWPQSACIKCVMPVKSWTIHGIWPDVHYCNDSWPFVPNDIKDIQPNLILAFWKHEWVKHGTCATSLPSLDSEHKYFQAGLNLRQKFDLSKMLSAAGIVPSLLDRLRNVIKNSHTRLLCMETKTKTE-QIIAQIEICLDKSFSPIDCDNFMDCPIKYLPI >NP_001193266.1 ribonuclease T2 precursor [Bos taurus] AFLGALCLALSCLGGALEWSKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSACNRSWPFNPHEIKDLLPDLLHQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLYKALALTSMLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQVELCFSKDLQLQNCSGLHVCPVLYPPL >XP_043313021.1 ribonuclease T2 [Cervus canadensis] AFLGALCLALSCLGSALEWGKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSACNRSWPFNPQEIKDLLPDLLHQFWSHEWKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTGLHVCPVLYPPL >NP_001086583.1 ribonuclease T2 L homeolog [Xenopus laevis] SLAILVTLVAVHYGFTQEWKKLILTHHWPATVCEHCKNPPKYWTLHGLWPDKAMCNNSWPFDSIQIKDILPDLLHQLWKHEWQKHGTCAASLECLNTQLKYFSKGLEIYKQVDLNSVLEKSGIIPSTMKDIENALIGVLPKIQCLPPHQGETAQTLGQIEICFTKEFQLRNCTDLHVCNTLYPPV >KAB0381136.1 hypothetical protein FD755_008920 [Muntiacus reevesi] PFCPHLCV-------CLEWGKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSACNRSWPFNPQEIKVLTPDALH---SHEWKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTGLHVCPVLYPPL >KAB0364565.1 hypothetical protein FD754_008721 [Muntiacus muntjak] PFCPHLCV-------CLEWGKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSACNRSWPFNPQEIKVLTPDALH---SHEWKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTGLHVCPVLYPPL >XP_015809255.1 PREDICTED: ribonuclease T2-like [Nothobranchius furzeri] --LS--SPLLFCLAAVQIWNKLTLTHHWPTTFCSHCHAKISYWTLHGLWPDNGECNSSWHFNSSQIEDLLPDLIKSFWKYEWQKHGTCAAEAESLNSQHKYFSKALELYHKLDLSSALNKFNIIPSDFSQIEGAIQGVTPKIQCAHSSKNTQVQNLGQIEICFDSEFTLLDCEGFKVCPVYYPPL >XP_023809297.1 ribonuclease T2 [Oryzias latipes] --LHVLSLLALCACVSHMWSKLILTHHWPNTFCSHCHPNISYWTLHGLWPDKGDCNSSWHFNPSLIEDLLPDLRNSFWKYEWHKHGTCAAKAESLNSQHKYFSKALELYHKLDLSSVLVKFGITPSDFSQVEGAIEGFKPKIQCVHSSKGGDFQSLGQIEICFDSDFTLMDCEGFSVCPVYYPPL >XP_030271242.1 ribonuclease T2-like isoform X1 [Sparus aurata] --LYYPLLFCLAAALSQMWTKLILTHHWPSTFCSHCHPNISYWTLHGLWPDKGDCNASWHFNASEIEDLLPDLLNGFWKYEWHKHGTCAARAASLNSEHKYFSKALELYHKVDLDSILKKFDITPSEFSQVEGAIEGVTPKIQCVHP-KNAEFQILGQIEICFNSDFTLMDCEGFLVCPVYYPPL >KAF4024724.1 hypothetical protein G4228_016581 [Cervus hanglu yarkandensis] -----------------------MVHHWPATVC----------------------------------------------------------------------------------------------VSDIRDALVKVVPKVQCFLLEKGQEVQLLGQMELCFSKDLQLLNCTGLHVCPVLYPPL >XP_005615626.1 ribonuclease T2 isoform X1 [Canis lupus familiaris] LLLSSLCLALCCPGGAHEWKKLIMVHHWPVTVCKDCRDPPDYWTIHGLWPDKAECNGSWHFHLEEIKDLMPDVIHHFWKHEWEKHGTCAAQLDALNSQKKYFGGSLDLYRDLDLNSMLQKLGIKPSIVSDIKDALAGVIPKIQCLPPQQGEEVQTIGQIELCFTKELRLRNCTGLEVCPAFYPPP >XP_016812107.1 ribonuclease T2 isoform X1 [Pan troglodytes] ALLGCLYLALLCLGGAHEWKKLIMVQHWPETVCEDCRDPPDYWTIHGLWPDKSGCNRSWPFNLEEIKDLLPDVIHRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSISSGLEE---QPFPDSPSTPTPGSRKMIACRALTVLTWTHVRIDEGHHLLSCPAACPGP >NP_001077407.1 ribonuclease T2-A isoform 1 precursor [Mus musculus] ALPGWIGLALCSLCGAHEWKKLILTQHWPPTVCKSCQDSLDYWTIHGLWPDRADCNQSWHFNLDEIKDLLPDVIHQFWKHEWVKHGTCAAQVDALNSEKKYFGKSLDLYKQIDLNSVLQKFGIKPSILADFKDALTGVVPKIQCLMPEQGESVQTVGQIELCFTKDLHLRNCTGMMVCPIFYPPP >XP_001928120.2 ribonuclease T2 [Sus scrofa] AGLGVLCLALCCLGGAHEWKKLIMVHHWPMTVCNNCEHPPDYWTIHGLWPDKSECNRSWPFNPDEIKGLLPDVLHHFWRHEWEKHGTCAAQLDALNSQRKYFGKTLDLYKELALNSTLQKLGIKPSIISDIKHALVGVVPKVQCLPPKSGEKVQTLGQIELCLTRDLQLQDCPGLEICPVFYPPP >XP_002833012.2 ribonuclease T2 [Pongo abelii] ALLGCLYLALLCLGGAHEWKKLIMVQHWPETVCEDCRDPPDYWTIHGLWPDKSGCNRSWPFNLEEIKDLLPDVIHRFWKHEWEKHGTCAAQVDALSSQKKYFGRSLELYRELDLNSVLLKLGIKPSIVADFKDALAGVIPKIQCLPPSQDEEVQTIGQIELCLTKDQQLQNCTGLRVCPVFYPPP >XP_003204111.2 ribonuclease T2 [Meleagris gallopavo] WILGCFSMASCCWCTSHTWKKLYLAHHWPVTVCKDCQDPPDYWTIHGLWPDKGECNRTWHFNVTEIKDLMPDVIHHFWKHEWEKHGTCAASLPILDSQKKYFSETLELYHHVDLNGFLLKAGIKPGSMADIKEVLTGVTPKIQCLPPEESEKAQTLGQIEFCFTKELKLRNCTELSVCPVYYPSQ >XP_003820272.1 ribonuclease T2 isoform X1 [Pan paniscus] ALLGCLYLALLCLGGAHEWKKLIMVQHWPETVCEDCRDPPDYWTIHGLWPDKSGCNRSWPFNLEEIKDLLPDVIHRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSIVADFKDALAGVIPKIQCLPPSQDEEVQTIGQIELCLTKDQQLQNCTGLRVCPVFYPPP >XP_023110339.1 ribonuclease T2 [Felis catus] LLLCALCLAMCRVGGAHEWKKLIMVHHWPVTVCKDCRDPPDYWTIHGLWPDKAECNRSWHFNFQEIKDLLPDVLHHFWQHEWEKHGTCAAQVDTLNSQKRYFGGGLDLYQKLALNSMLQKLGIKPSIISDIKDALAGVIPKVQCLPPESGEEVQTIGQIEVCFTKGLQLRNCTGLEVCPAFYPPP >XP_027828458.1 ribonuclease T2 [Ovis aries] AFLGALCLALSCLGGALEWSKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSVCNRSWPFNPKEIKDLLPDLLHQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLYKALALTSMLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQIELCFSKDLQLWNCSGLHVCPVLYPPL >XP_004044997.1 ribonuclease T2 isoform X1 [Gorilla gorilla gorilla] ALLGCLYLALLCLGGAHEWKKLIMVQHWPETVCEDCRDPPDYWTIHGLWPDKSGCNRSWPFNLEEIKDLLPDVIHRFWKHEWEKHGTCAAQVDALNSQKKYFGRSLELYRELDLNSVLLKLGIKPSIVADFKDALAGVIPKIQCLPPSQDEEVQTIGQIELCLTKDQQLQNCTGLRVCPVFYPPP >XP_005508662.2 ribonuclease T2 [Columba livia] WILGWFSMALCCWCISHTWKKLFLAHHWPVTVCKDCQDPPDYWTIHGLWPDKGECNRTWHFNVTEIKDLMPDVLHQFWKHEWDKHGTCATTLQALNSQKKYFGKALELYKHIDLNSCLLKAGIKPSSMTDIKEALTGVTPKIQCLLPEEGEKAQTIGQIEFCFTKEFQLRNCTELSICPTYYPSE >XP_017908952.1 PREDICTED: ribonuclease T2 [Capra hircus] AFLGALCLALSCLGGALEWSKLIMVHHWPATVCQHCKDPPNYWTIHGLWPDKSVCNRSWPFNPKEIKDLLPDLLHQFWSHEWKKHGTCAAQLDALNSQRKYFGKSLDLFKALALTSMLQKLGIEPSTVSDIRDALVKVVPKVQCFLLEKGQEVQLLGQIELCFSKDLQLWNCSGLHVCPVLYPPL >XP_006034588.1 ribonuclease T2 [Alligator sinensis] LTLGYFLMFFYCGCTSHTWDKLILVHHWPVTVCKDCDDPPQFWTIHGLWPDKGDCNRTWHFNVNEIEDLLPDILHRFWKHEWQKHGTCAAAIEPLNSQKKYFGKALDLYHKVDLNSYLLKVGIKPGHMSAIKEALTGVTQKIQCIPPEEDEDVQTIGQIEFCFTKELELRNCTELSIC-TSYPLE >XP_006261115.1 PREDICTED: ribonuclease T2 [Alligator mississippiensis] LTLGYFVMFFYCGCTSHTWDKLILVHHWPVTVCKDCDDPPQFWTIHGLWPDKGDCNRTWHFNVNEIEDLLPDILHHFWKHEWQKHGTCAAAIEPLNSQKKYFGKALDLYHKVDLNSYLLKVGIKPGHMSAIKEALTGVSPKIQCIPPEEDEDVQTIGQIEFCFTKELELRNCTELSIC-TSYPLE >XP_008250933.1 PREDICTED: ribonuclease T2 [Oryctolagus cuniculus] ALLGGLCLALLLQAGAHEWKKLILVQHWPATVCEDCREPPDYWTIHGLWPDKGECNRSWHFNLDEIKDLLPDVIHQFWKHEWEKHGTCAAQLEALNSQRKYFGTSLALYKQLDLNSKLLKLGIKPSILADFKDALTGVVPKIQCLPPEQDEQVQTIGQIELCYTKDLHLRNCTGLSVCPVFYPPP >XP_020741611.1 ribonuclease T2 [Odocoileus virginianus texanus] AFLGALCLALSCLGSALEWGKLIMVHHWPATVCQHCKDPPSYWTIHGLWPDKSACNRSWPFNPQEIKDLLPDLLHQFWSHEWKKHGTCAAQLDALNSQWKYFSKSLDLYKELALSSVLQKLGIEPSIVSDIRDALVKVVPKVQCFLLEKGQELQLLGQMELCFSKDLQLLNCTGLHVCPVLYPPL >XP_040206575.1 ribonuclease T2 isoform X1 [Rana temporaria] ILLVTCSLCAIHSSFVPEWKKLILTHHWPVTVCKKCDDLPNYWTLHGLWTDKEMCNKSWPFDFSEIKDILPDVLHQLWKHEWQKHGTCAASLPCLNTQHKYFSKGLELYTRISLSSALEKSGIKPANVEEIEDVILGVIPKIQCIPPQQGEDAQTLGQIEICFTKDFDLRNCTDLHVCNTYYPPV
PhyML tree of selected proteins (XP_040206575_1_ribonuclease_T2_isoform_X1__Rana_temporaria_:0.22665395,NP_001086583_1_ribonuclease_T2_L_homeolog__Xenopus_laevis_:0.16403669,((((XP_008250933_1_PREDICTED__ribonuclease_T2__Oryctolagus_cuniculus_:0.10160489,(NP_001099680_1_ribonuclease_T2_precursor__Rattus_norvegicus_:0.03907899,NP_001077407_1_ribonuclease_T2_A_isoform_1_precursor__Mus_musculus_:0.03312924):0.14973255):0.02968628,(((sp_O00584_RNT2_HUMAN_Ribonuclease_T2_OS_Homo_sapiens_OX_9606_GN_RNASET2_PE_1_SV_2:0.00000001,(XP_016812107_1_ribonuclease_T2_isoform_X1__Pan_troglodytes_:0.450883,(XP_002833012_2_ribonuclease_T2__Pongo_abelii_:0.00565366,(XP_003820272_1_ribonuclease_T2_isoform_X1__Pan_paniscus_:0.00000001,XP_004044997_1_ribonuclease_T2_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00566658):0.12621646,(XP_001928120_2_ribonuclease_T2__Sus_scrofa_:0.1371992,((NP_001193266_1_ribonuclease_T2_precursor__Bos_taurus_:0.00868005,(XP_017908952_1_PREDICTED__ribonuclease_T2__Capra_hircus_:0.00546627,XP_027828458_1_ribonuclease_T2__Ovis_aries_:0.00000001):0.01595344):0.0159497,((XP_020741611_1_ribonuclease_T2__Odocoileus_virginianus_texanus_:0.01671007,XP_043313021_1_ribonuclease_T2__Cervus_canadensis_:0.00000001):0.00000001,(KAF4024724_1_hypothetical_protein_G4228_016581__Cervus_hanglu_yarkandensis_:0.00000001,(KAB0381136_1_hypothetical_protein_FD755_008920__Muntiacus_reevesi_:0.00000001,KAB0364565_1_hypothetical_protein_FD754_008721__Muntiacus_muntjak_:0.00000001):0.00000001):0.0587205):0.04451674):0.20392515):0.06651068):0.0169415,(XP_005615626_1_ribonuclease_T2_isoform_X1__Canis_lupus_familiaris_:0.05349343,XP_023110339_1_ribonuclease_T2__Felis_catus_:0.12426538):0.05418205):0.06236136):0.11061931,((XP_005508662_2_ribonuclease_T2__Columba_livia_:0.05729576,(XP_003204111_2_ribonuclease_T2__Meleagris_gallopavo_:0.02645446,NP_001034580_1_ribonuclease_T2_precursor__Gallus_gallus_:0.05301203):0.1072568):0.05487546,(XP_006261115_1_PREDICTED__ribonuclease_T2__Alligator_mississippiensis_:0.00409767,XP_006034588_1_ribonuclease_T2__Alligator_sinensis_:0.01797814):0.2556007):0.1610011):0.20734944,((sp_B8XY56_RNT2_DANRE_Ribonuclease_T2_OS_Danio_rerio_OX_7955_GN_rnaset2_PE_2_SV_1:0.31382841,(XP_023809297_1_ribonuclease_T2__Oryzias_latipes_:0.04816822,(XP_030271242_1_ribonuclease_T2_like_isoform_X1__Sparus_aurata_:0.15367696,XP_015809255_1_PREDICTED__ribonuclease_T2_like__Nothobranchius_furzeri_:0.22208906):0.04666301):0.22641358):0.16405506,(((XP_031570988_1_ribonuclease_Oy_like__Actinia_tenebrosa_:0.97903038,XP_039248172_1_ribonuclease_Oy_like__Styela_clava_:0.80025643):0.05706246,(XP_038078907_1_ribonuclease_Oy_like__Patiria_miniata_:0.70925205,XP_780287_3_ribonuclease_Oy__Strongylocentrotus_purpuratus_:0.68508703):0.25644379):0.09160743,(AAL25297_1_GH08338p__Drosophila_melanogaster_:1.05741215,(CAE1331125_1_RNASET2__Sepia_pharaonis_:0.66137235,NP_503370_1_Ribonuclease_T2_protein_rnst_2__Caenorhabditis_elegans_:1.2456547):0.17468846):0.11128862):0.54912432):0.19837883):0.20243193);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)