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PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0059 | P04083 | Annexin A1 | ANXA1 | ANX1, LPC1 | Homo_sapiens | Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca2+-dependent interaction between phagosomes and the actin cytoskeleton (By similarity). |
Domains | Gene Ontology |
PF00191 (Annexin) |
GO:0005884 (colocalizes with) actin filament
GO:0004859 (enables) phospholipase inhibitor activity GO:0005102 (enables) signaling receptor binding GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0005543 (enables) phospholipid binding GO:0005544 (enables) calcium-dependent phospholipid binding GO:0019834 (enables) phospholipase A2 inhibitor activity GO:0046872 (enables) metal ion binding GO:0048306 (enables) calcium-dependent protein binding GO:0098641 (enables) cadherin binding involved in cell-cell adhesion GO:0001780 (involved in) neutrophil homeostasis GO:0002250 (involved in) adaptive immune response GO:0002376 (involved in) immune system process GO:0002548 (involved in) monocyte chemotaxis GO:0002685 (involved in) regulation of leukocyte migration GO:0006909 (involved in) phagocytosis GO:0006954 (involved in) inflammatory response GO:0007165 (involved in) signal transduction GO:0007166 (involved in) cell surface receptor signaling pathway GO:0007187 (involved in) G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008360 (involved in) regulation of cell shape GO:0009410 (involved in) response to xenobiotic stimulus GO:0010165 (involved in) response to X-ray GO:0014839 (involved in) myoblast migration involved in skeletal muscle regeneration GO:0018149 (involved in) peptide cross-linking GO:0030073 (involved in) insulin secretion GO:0030216 (involved in) keratinocyte differentiation GO:0030850 (involved in) prostate gland development GO:0031018 (involved in) endocrine pancreas development GO:0031340 (involved in) positive regulation of vesicle fusion GO:0031394 (involved in) positive regulation of prostaglandin biosynthetic process GO:0031532 (involved in) actin cytoskeleton reorganization GO:0032355 (involved in) response to estradiol GO:0032508 (involved in) DNA duplex unwinding GO:0032652 (involved in) regulation of interleukin-1 production GO:0032717 (involved in) negative regulation of interleukin-8 production GO:0032743 (involved in) positive regulation of interleukin-2 production GO:0033031 (involved in) positive regulation of neutrophil apoptotic process GO:0035924 (involved in) cellular response to vascular endothelial growth factor stimulus GO:0042063 (involved in) gliogenesis GO:0042102 (involved in) positive regulation of T cell proliferation GO:0042127 (involved in) regulation of cell population proliferation GO:0043066 (involved in) negative regulation of apoptotic process GO:0043434 (involved in) response to peptide hormone GO:0045087 (involved in) innate immune response GO:0045627 (involved in) positive regulation of T-helper 1 cell differentiation GO:0045629 (involved in) negative regulation of T-helper 2 cell differentiation GO:0045920 (involved in) negative regulation of exocytosis GO:0046632 (involved in) alpha-beta T cell differentiation GO:0046883 (involved in) regulation of hormone secretion GO:0050482 (involved in) arachidonic acid secretion GO:0050727 (involved in) regulation of inflammatory response GO:0070301 (involved in) cellular response to hydrogen peroxide GO:0070365 (involved in) hepatocyte differentiation GO:0070459 (involved in) prolactin secretion GO:0070555 (involved in) response to interleukin-1 GO:0071385 (involved in) cellular response to glucocorticoid stimulus GO:0071621 (involved in) granulocyte chemotaxis GO:0090050 (involved in) positive regulation of cell migration involved in sprouting angiogenesis GO:0090303 (involved in) positive regulation of wound healing GO:0097350 (involved in) neutrophil clearance GO:0098609 (involved in) cell-cell adhesion GO:1900087 (involved in) positive regulation of G1/S transition of mitotic cell cycle GO:1900138 (involved in) negative regulation of phospholipase A2 activity GO:0001533 (located in) cornified envelope GO:0001891 (located in) phagocytic cup GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005654 (located in) nucleoplasm GO:0005737 (located in) cytoplasm GO:0005768 (located in) endosome GO:0005769 (located in) early endosome GO:0005829 (located in) cytosol GO:0005886 (located in) plasma membrane GO:0005912 (located in) adherens junction GO:0005925 (located in) focal adhesion GO:0005929 (located in) cilium GO:0009986 (located in) cell surface GO:0010008 (located in) endosome membrane GO:0016020 (located in) membrane GO:0016323 (located in) basolateral plasma membrane GO:0016324 (located in) apical plasma membrane GO:0016328 (located in) lateral plasma membrane GO:0019898 (located in) extrinsic component of membrane GO:0030659 (located in) cytoplasmic vesicle membrane GO:0031232 (located in) extrinsic component of external side of plasma membrane GO:0031313 (located in) extrinsic component of endosome membrane GO:0031410 (located in) cytoplasmic vesicle GO:0031514 (located in) motile cilium GO:0031901 (located in) early endosome membrane GO:0031982 (located in) vesicle GO:0042383 (located in) sarcolemma GO:0042995 (located in) cell projection GO:0070062 (located in) extracellular exosome GO:0062023 (part of) collagen-containing extracellular matrix |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |