PBID | Uniprot | Name | Gene | Alternative | Organism | Uniprot Description |
PB0058 | P02787 | Serotransferrin | TF | HEL-S-71p, PRO1557, PRO2086, TFQTL1, transferrin | Homo_sapiens | (Microbial infection) Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use. |
Domains | Gene Ontology |
PF00405 (2_Transferrin) |
GO:0005515 (enables) protein binding
GO:0008198 (enables) ferrous iron binding GO:0008199 (enables) ferric iron binding GO:0034986 (enables) iron chaperone activity GO:0046872 (enables) metal ion binding GO:1990459 (enables) transferrin receptor binding GO:0001895 (involved in) retina homeostasis GO:0006811 (involved in) ion transport GO:0006826 (involved in) iron ion transport GO:0006879 (involved in) cellular iron ion homeostasis GO:0007015 (involved in) actin filament organization GO:0009617 (involved in) response to bacterium GO:0019731 (involved in) antibacterial humoral response GO:0030316 (involved in) osteoclast differentiation GO:0034756 (involved in) regulation of iron ion transport GO:0042327 (involved in) positive regulation of phosphorylation GO:0045780 (involved in) positive regulation of bone resorption GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0048260 (involved in) positive regulation of receptor-mediated endocytosis GO:0055072 (involved in) iron ion homeostasis GO:0060395 (involved in) SMAD protein signal transduction GO:0070371 (involved in) ERK1 and ERK2 cascade GO:0071281 (involved in) cellular response to iron ion GO:2000147 (involved in) positive regulation of cell motility GO:0005886 (is active in) plasma membrane GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005768 (located in) endosome GO:0005769 (located in) early endosome GO:0005770 (located in) late endosome GO:0005788 (located in) endoplasmic reticulum lumen GO:0005905 (located in) clathrin-coated pit GO:0009925 (located in) basal plasma membrane GO:0009986 (located in) cell surface GO:0010008 (located in) endosome membrane GO:0016020 (located in) membrane GO:0016324 (located in) apical plasma membrane GO:0030139 (located in) endocytic vesicle GO:0030669 (located in) clathrin-coated endocytic vesicle membrane GO:0031232 (located in) extrinsic component of external side of plasma membrane GO:0031410 (located in) cytoplasmic vesicle GO:0031982 (located in) vesicle GO:0034774 (located in) secretory granule lumen GO:0045178 (located in) basal part of cell GO:0048471 (located in) perinuclear region of cytoplasm GO:0055037 (located in) recycling endosome GO:0070062 (located in) extracellular exosome GO:0072562 (located in) blood microparticle GO:1990712 (part of) HFE-transferrin receptor complex |
External Links | Description |
Intact | Open source database system and analysis tools for molecular interaction data. |
Protein Atlas | An open access resource for human proteins |
InterPro (new pfam) | InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. |