PB0057

DATABASE

Click here to access PB0057 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0057	P26583	High mobility group protein B2	HMGB2	HMG2, high mobility group box 2	Homo_sapiens	Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).

Domains

Gene Ontology

PF00505 (HMG_box) PF09011 (HMG_box_2)

GO:0000400 (enables) four-way junction DNA binding GO:0000976 (enables) transcription cis-regulatory region binding GO:0000987 (enables) cis-regulatory region sequence-specific DNA binding GO:0003677 (enables) DNA binding GO:0003684 (enables) damaged DNA binding GO:0003690 (enables) double-stranded DNA binding GO:0003697 (enables) single-stranded DNA binding GO:0003713 (enables) transcription coactivator activity GO:0003723 (enables) RNA binding GO:0005515 (enables) protein binding GO:0008134 (enables) transcription factor binding GO:0008301 (enables) DNA binding, bending GO:0019904 (enables) protein domain specific binding GO:0042056 (enables) chemoattractant activity GO:0044378 (enables) non-sequence-specific DNA binding, bending GO:0050786 (enables) RAGE receptor binding GO:0097100 (enables) supercoiled DNA binding GO:0000122 (involved in) negative regulation of transcription by RNA polymerase II GO:0001938 (involved in) positive regulation of endothelial cell proliferation GO:0002376 (involved in) immune system process GO:0002437 (involved in) inflammatory response to antigenic stimulus GO:0006265 (involved in) DNA topological change GO:0006303 (involved in) double-strand break repair via nonhomologous end joining GO:0006310 (involved in) DNA recombination GO:0006325 (involved in) chromatin organization GO:0006334 (involved in) nucleosome assembly GO:0006357 (involved in) regulation of transcription by RNA polymerase II GO:0006935 (involved in) chemotaxis GO:0006954 (involved in) inflammatory response GO:0007283 (involved in) spermatogenesis GO:0007289 (involved in) spermatid nucleus differentiation GO:0008584 (involved in) male gonad development GO:0010628 (involved in) positive regulation of gene expression GO:0010629 (involved in) negative regulation of gene expression GO:0032075 (involved in) positive regulation of nuclease activity GO:0032392 (involved in) DNA geometric change GO:0032496 (involved in) response to lipopolysaccharide GO:0032728 (involved in) positive regulation of interferon-beta production GO:0033151 (involved in) V(D)J recombination GO:0043388 (involved in) positive regulation of DNA binding GO:0045087 (involved in) innate immune response GO:0045089 (involved in) positive regulation of innate immune response GO:0045648 (involved in) positive regulation of erythrocyte differentiation GO:0045654 (involved in) positive regulation of megakaryocyte differentiation GO:0045892 (involved in) negative regulation of transcription, DNA-templated GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0045944 (involved in) positive regulation of transcription by RNA polymerase II GO:0048545 (involved in) response to steroid hormone GO:0050767 (involved in) regulation of neurogenesis GO:0050829 (involved in) defense response to Gram-negative bacterium GO:0050830 (involved in) defense response to Gram-positive bacterium GO:0050918 (involved in) positive chemotaxis GO:0060326 (involved in) cell chemotaxis GO:0071222 (involved in) cellular response to lipopolysaccharide GO:0072091 (involved in) regulation of stem cell proliferation GO:1902042 (involved in) negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:0000785 (located in) chromatin GO:0000793 (located in) condensed chromosome GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005654 (located in) nucleoplasm GO:0005694 (located in) chromosome GO:0005730 (located in) nucleolus GO:0005737 (located in) cytoplasm GO:0048471 (located in) perinuclear region of cytoplasm GO:0032991 (part of) protein-containing complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P26583|HMGB2_HUMAN High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGL SIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTG SKKKNEPEDEEEEEEEEDEDEEEEDEDEE >tr|B8JL29|B8JL29_DANRE High mobility group box 2a OS=Danio rerio OX=7955 GN=hmgb2a PE=1 SV=1 MGKDPNKPRGKTSSYAFFVQTCREEHKKKNPGTSVNFSEFSKKCSERWRTMSSKEKGKFE EMAKTDKVRYDREMKNYVPPKGAKGGKKKKDPNAPKRPPSAFFVFCSDHRPKVKGDNPGI SIGDIAKKLGEMWSKLSPKEKSPYEQKAMKLKEKYEKDVAAYRAKGGKPDGAKKGGPGRP AGKKAEADDDDDEDEDEEDEEEEDEEDEDDDDE >tr|Q66IB6|Q66IB6_DANRE High mobility group box 2b OS=Danio rerio OX=7955 GN=hmgb2b PE=1 SV=1 MVKGDVNKPKGKTSAYAFFVQTCRDEHKRKSPDVPVNFSEFSKKCSERWKSLNASDKVKF EDMAKADKVRYDREMKTYVPPKGVGKTGRKKKDPNAPKRPPSAFFVFCSEYRPTVKSEHP NLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGGGASKRGPGRPTG SVKKSQAEADDDDDEDEDEEDEEDDEEEEDEDDE
Selected proteins from model organisms >sp|P26583|HMGB2_HUMAN High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGL SIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTG SKKKNEPEDEEEEEEEEDEDEEEEDEDEE >tr|B8JL29|B8JL29_DANRE High mobility group box 2a OS=Danio rerio OX=7955 GN=hmgb2a PE=1 SV=1 MGKDPNKPRGKTSSYAFFVQTCREEHKKKNPGTSVNFSEFSKKCSERWRTMSSKEKGKFE EMAKTDKVRYDREMKNYVPPKGAKGGKKKKDPNAPKRPPSAFFVFCSDHRPKVKGDNPGI SIGDIAKKLGEMWSKLSPKEKSPYEQKAMKLKEKYEKDVAAYRAKGGKPDGAKKGGPGRP AGKKAEADDDDDEDEDEEDEEEEDEEDEDDDDE >NP_001079576.1 high mobility group box 2 L homeolog [Xenopus laevis] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDTSVNFSDFSKKCSERWKSMSAKEKGKFEDLAKGDKARYEREMKTYIP PKGETKGKRKKDPNAPKRPPSAFFIFCSEHRPQIKSETPGLSIGDTAKKLGELWAEQTPKDKLPHEQKAAKLKEKYEKDV AAYRAKGKSDVGKKVPGRATGSKKKVEPHHHDDEEDEDEEDEEDEDDDDDDE >OWK05981.1 hypothetical protein Celaphus_00012630 [Cervus elaphus hippelaphus] MELVHKQSKAVSVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQDQLLAFTVIQLLEQEFTPEPGQQRR GETRPLRGTLRKGDPNKPRGKMSPYAFSLQTCCEEHKKHPDSSVNFAEFSKKCSERWKTMSTKEKPKFGDMAKSDKARYD REMKNYVPPKGDKGKKKDPNAPKGPPSAFFLFCSEYCPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKE KYEKGTAAYRAKGKSEAGKKGPGRPTGSKKKNEPQDEEEEEEEEDEDEEEEEEDEE >KAF4020859.1 hypothetical protein G4228_012444 [Cervus hanglu yarkandensis] MRKGDPNKPRGKMSPYAFSVQTCCEEHKKHPDSSVNFAEFSKKCSERWKTMSTKEKPKFGDMAKSDKACYDREMKNYVPP KGDKGKKKDPNAPKGPPSAFFLFCSEYCPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKGTAAY RAKGKSEAGKKGPGRPTGSKKKNEPQDEEEEEEEEDEDEEEEEEDEE >KAB0344535.1 hypothetical protein FD754_021461 [Muntiacus muntjak] MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKAHYEREMKTYIP PKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDRQPYEKNAAKLKEKYEKDIA AYRAKGKPDAAKKRVVKAEKSKKKKEEEEDEEDEEDEEEEKDEEDEEEEEEDDDE >KAB0381219.1 hypothetical protein FD755_009003 [Muntiacus reevesi] MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIP PKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTATDDKQPYEKKAAKLKEKYEKEIA AYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEVEDDDDE >XP_043310239.1 high mobility group protein B1-like [Cervus canadensis] MGKGDPKKPRGKMSSYAFFVQTCRGEHKKQHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIP PKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIA AYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEEEDDDDE >XP_015828886.1 PREDICTED: high mobility group protein B2-like [Nothobranchius furzeri] MTKDPNKPRGKTSAYAFFVATCREEHKKKHPGTSVNFAEFSKKCSERWKTMSAKEKVKFDEMAKTDKVRYDREMKTYVPP KGAKKGKKKKDPNAPKRPPSAFFVFCSDHRPRIKEENPGISIGDVAKKLGELWSTQGSKDKAPYEARAAKLKEKYEKDVA AYRAKGGSGKSDAGRKSGPGRPPAKKAEPADDDDDEDEDEEEDEDEEDDDDE >tr|Q66IB6|Q66IB6_DANRE High mobility group box 2b OS=Danio rerio OX=7955 GN=hmgb2b PE=1 SV=1 MVKGDVNKPKGKTSAYAFFVQTCRDEHKRKSPDVPVNFSEFSKKCSERWKSLNASDKVKF EDMAKADKVRYDREMKTYVPPKGVGKTGRKKKDPNAPKRPPSAFFVFCSEYRPTVKSEHP NLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGGGASKRGPGRPTG SVKKSQAEADDDDDEDEDEEDEEDDEEEEDEDDE >NP_058883.1 high mobility group protein B2 [Rattus norvegicus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEVGKKGPGRPTGSKKKNEPEDEEEEEEEEDDEDEEEEDEDEE >XP_039265455.1 high mobility group protein B2-like [Styela clava] MGKKDPNKPRGKMTAYAFFVQTCRQEHKKSHPDEQVVFAEFSRKCAERWKDMNTKEKKIFNDMAGRDKLRYDREMEGYCP PAGEGKKPQKRKKDPNAPKRPQSAFFLFCGDRRAEIKKENPSFTVGDIAKKLGKLWSEASKDIKEKYDDLGKLAKKQYEK DLKAYKDGQQQAGKAKKQKKEESSSSSSSSSSSGSDSDRDSD >CAA57212.1 unnamed protein product [Drosophila melanogaster] MASSFPNPATTMAQVVATSNAAGTTGYDYRLNMAQAAAAAAVPGSQWWYSAANQGQVDANTAAQLQHQQQQQQQQQQQQQ QQHQQQQQMQQQQQQQNVINSASPMSRVKADAKPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDK EKKRFHEMAEKDKQRYEAEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKEL GRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASMQAQAQKAALLAAAAQQQHQQLEEQHDDDDG DGDDDENQ >XP_026296431.1 high mobility group protein DSP1 [Apis mellifera] MSEHHRVAGGWGTASPGSREDASGGTAWWPSGLNTVSAEQQQQQQQQQQQQQNLHQHLMNQQQQQLTQQQQAQQQHHQDI VRSTAAATQQLFSYKMASSFQNPATTGTQSNPVSTSTPVGSCMRGGYDYRLGTGPGTGGGVPGTPSAPPPGVQWWYPGGV MDAGQNNLHQQLQGQQQQQHLSPITTQTSTPPVMSPHQIQQLSQQNNLQQNNAQSLQQRDNMPRGKDSKPRGRMTAYAFF VQTCRQEHKKKHPEEKIVFREFSKKCAMRWKTMSDKEKKRFHEMAEKDKKRYDAEMQNYTPPKGESKGRGKKRKHIKDHN APKRSLSAFFWFCNDERGKVKMLNPEFGVGDIAKELGKKWSDADPETKSKYEAMAEKDKARYEREMTAYKKKMKDGAPVV GVPANTVKSDSEEEYKEDDE >XP_038054924.1 high mobility group protein 1 homolog isoform X1 [Patiria miniata] MGRKDPNKPKGRMSSYAFFVQFCREEHKERNPGQSVNFTQFSKKCSERWKTMDDGEKKRFLECADCDKMRYEREMARYVP PKGTKKRGRRKRKDPNAPKRNLSAFFLFSNDERSKVKAVHPDWGIGKIAQVLAEQWRNVSASQRAKYDKAAVQDKERYVK AMAEYKAKPVKKKSSSSSSSSSSSSSSSSSSSSSDEE >NP_999708.1 high mobility group protein 1 homolog [Strongylocentrotus purpuratus] MGKKDRDSSKPRGRMSAYAYFVQDSRAEHGKNHPNSPVRFAEFSKDCSARWKALEEKGKGVFHEKSMRDKVRYDREMQSY KPPKGEKNKRRRRRKDPDAPKRNLSAFFIFSGENRAAIKSVHPNWSVGDIAKELAVRWRAMTAGEKIPFDKGAAKDKERY IKAMAEYKAKAKPMKRQVKESSSSSSSDSSSDDSSSDDSD >NP_001380091.1 High mobility group protein 1.2 [Caenorhabditis elegans] MNSGYSANIFPSSSSPTLYQSHQLQPNPSATMYQATPRDMGKPPVRGKTSPYGFFVKMCYEEHKKKYPNENVQVTEISKK CSEKWKTMVDDEKRRFYELAQKDAERYQAEVAAYGGEDAMRKRKRAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKV GQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKAEMQKMSGMDHYDDDNIHHVVHVEDINSQNIS >CAE1251870.1 HMGB1 [Sepia pharaonis] MFSRCQNLRQLKNTRYDGRHIPPSQFINQAIWACKEEHERQHPGVKLDFTEFSRKCSEKWSTMVPEEINLFEVMAKKQKM RYETELASHMPPPVEQKKGKRKRVKDPNAPKRSLSAFFFFCKDERPKSIKENPSLKPSEVATMLGQKWKTISADVKGIYE KKAAKDKLRYKKEMAIFKSQQAKEALVVEKSPPKPPSEDEEEEEEKEEEVVVPPPKVAKVVKQEIPVVNNQPESEEEEEE EDDDDDDDDDSDDDDDDDDDDDDDDDDDDDRI >XP_031569961.1 high mobility group protein B1-like [Actinia tenebrosa] MPKVSKKDPNKPKGAKSAYNFFLQDQKEHMKGENGESLPLQEFSRSCADKWKNMSGEEKKPYTDKAEKDKTRYLKEMSSY SPPPAEEQNSGKKMKKKKIKDPNKPKKNLSAYMFFLADKRPSVKESLGDVSTTAVLKALGEMWSKTPESDKGEYQELAKK DRQRYDEEMKEYNNKTQGLSDGKKSVAVENGTATDD >NP_032278.1 high mobility group protein B2 [Mus musculus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE >NP_990817.1 high mobility group protein B2 [Gallus gallus] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKAR YDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQLAKD KQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEEEDEE >NP_999228.1 high mobility group protein B2 [Sus scrofa] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKGEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDEEEEDEDEE >XP_517538.3 high mobility group protein B2 [Pan troglodytes] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_543194.2 high mobility group protein B2 [Canis lupus familiaris] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDDEEEEEDEE >NP_001032705.1 high mobility group protein B2 [Bos taurus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_002709517.1 PREDICTED: high mobility group protein B2 [Oryctolagus cuniculus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDDEEEDEDEE >XP_003776594.1 high mobility group protein B2 [Pongo abelii] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDEEEEDEDEE >XP_010708063.1 high mobility group protein B2 [Meleagris gallopavo] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKAR YDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEEDEEEEEEEEDEE >XP_003823467.1 high mobility group protein B2 [Pan paniscus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_003984907.1 high mobility group protein B2 [Felis catus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEDEDDEEEEEDEE >XP_014948765.2 high mobility group protein B2 [Ovis aries] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_004040680.1 high mobility group protein B2 [Gorilla gorilla gorilla] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEDEDEEEEDEDEE >XP_020555797.1 high mobility group protein B2 isoform X1 [Oryzias latipes] MKLPPASEARSVAEKARLRQIEAMTKDPNKPRGKTSAYAYFVATCREEHKKKHPGTSVNFAEFSKKCSER WKTMSSKEKVKFDELAKTDKARYDREMKTYVPPKGAKKVKKKKDPNAPKRPPSAFFVFCSDHRPKIKEDN PGISIGDIAKKLGELWATQSAKDKAPYEAKAAKLKEKYEKDVAAYRAKGGSGKSDAGKKSGPGRPAAKKA VPVHDDDDDDDEEDEDDEEDDDEDDDE >XP_005510965.1 high mobility group protein B2 [Columba livia] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKAR YDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEDEDEE >XP_017907305.1 PREDICTED: high mobility group protein B2 [Capra hircus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_006022293.1 high mobility group protein B2 [Alligator sinensis] MSGKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKTEHPGLS IGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDVAAYRAKSKSDVGKKGPGRPAGSKKKAEPEEEE EEEEDEEEEEEEEEEDEE >XP_006273433.1 PREDICTED: high mobility group protein B2 [Alligator mississippiensis] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSGKEKGKFEEMAKGDKAR YDREMKNYVPPKGEKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKTEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEDDDDEEEEEEEDEE >XP_020753973.1 high mobility group protein B2 [Odocoileus virginianus texanus] MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKAR YDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKD KQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_030292285.1 high mobility group protein B2 [Sparus aurata] MRKDPKKPRGKMTSYAYFVATCREEHKKKHPGAAVAFTEFSKKCSERWKTMSPKEKVKFEDMAKNDKIRY DQEMKSYVPPKGEKSKKKKKDPNAPKRPPSAFFVFCSDHRPRIKEENPGISIGDIAKKLGELWSTQSPKD KAPYSAKAAKLKEKYDKDVAVYRAKCGSGKSDAGKKSGPGRPSAKKAEPVDDDDDDDDDDDEEEDDEDDD DDEDDD >XP_040189311.1 high mobility group protein B2 [Rana temporaria] MGKGDPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKGKFEDLAKGDKVR YEREMKTYIPPKGEKAGKRKKDPNAPKRPPSAFFLFCSENRPQIKTDTPGLSIGDTAKKLGELWSEQTPK DKQPFEQKAAKLKEKYEKDVAAYRAKGTSDVGKKIPGRPASSKKKVEPEDDDDDEDEDDEEDEDEDDDED DE
Mafft alignment of selected proteins >sp|P26583|HMGB2_HUMAN High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEDEDEE---------- >tr|B8JL29|B8JL29_DANRE High mobility group box 2a OS=Danio rerio OX=7955 GN=hmgb2a PE=1 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGK----DP NKP--RGKTSSYAFFVQ----TCREEHKKKNPGTSVNFSEFSKKCSERWRTMSSKEKGKF EEMAKTDKVRYDREMKNYVPPKGA-------KGGKKKKDPNAPKRPPSAFFVFCSDHRPK VKGDNPGISIGDIAKKLGEMWSKLSPKEKSPYEQKAMKLKEKYEKDVAAYRAKG--GKPD GAKKGGPGRPAG--------------------------------------KKAEADDDDD E-DEDEEDEEEEDEEDEDDDDE------ >NP_001079576.1 high mobility group box 2 L homeolog [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDTSVNFSDFSKKCSERWKSMSAKEKGKF EDLAKGDKARYEREMKTYIPPKGE-------TKGKRKKDPNAPKRPPSAFFIFCSEHRPQ IKSETPGLSIGDTAKKLGELWAEQTPKDKLPHEQKAAKLKEKYEKDVAAYRAKG---KSD VGKK-VPGRATG------------------------------------SKKKVEPHHHDD E-EDEDEEDEEDEDDDDDDE-------- >OWK05981.1 hypothetical protein Celaphus_00012630 [Cervus elaphus hippelaphus] M-------------------------------------------------------ELVH KQSK--------------------------------AVSV------------TSMSFPVG D-------------------VNNFVVGSEEGSV--YTACRHGS-KAGISEMFEGHQDQL- -------------LAFTVIQLLEQEFTPEPGQQRRGETRPLRGT-------LRKG---DP NKP--RGKMSPYAFSLQ----TCCEEH-KKHPDSSVNFAEFSKKCSERWKTMSTKEKPKF GDMAKSDKARYDREMKNYVPPKGD--------KG-KKKDPNAPKGPPSAFFLFCSEYCPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKGTAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPQDEEE E-EEEEDEDEEEEEEDEE---------- >KAF4020859.1 hypothetical protein G4228_012444 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MRKG---DP NKP--RGKMSPYAFSVQ----TCCEEH-KKHPDSSVNFAEFSKKCSERWKTMSTKEKPKF GDMAKSDKACYDREMKNYVPPKGD--------KG-KKKDPNAPKGPPSAFFLFCSEYCPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKGTAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPQDEEE E-EEEEDEDEEEEEEDEE---------- >KAB0344535.1 hypothetical protein FD754_021461 [Muntiacus muntjak] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP KKP--RGKMSSYAFFVQ----TCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKF EDMAKADKAHYEREMKTYIPPKGE--------TKKKFKDPNAPKRPPSAFFLFCSEYRPK IKGEHPGLSIGDVAKKLGEMWNNTAADDRQPYEKNAAKLKEKYEKDIAAYRAKG---KPD AAKK-RVVKAEK------------------------------------SKKKKEEEEDEE D-EEDEEEEKDEEDEEEEEEDDDE---- >KAB0381219.1 hypothetical protein FD755_009003 [Muntiacus reevesi] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP KKP--RGKMSSYAFFVQ----TCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKF EDMAKADKARYEREMKTYIPPKGE--------TKKKFKDPNAPKRPPSAFFLFCSEYRPK IKGEHPGLSIGDVAKKLGEMWNNTATDDKQPYEKKAAKLKEKYEKEIAAYRAKG---KPD AAKK-GVVKAEK------------------------------------SKKKKEEEEDEE D-EEDEEEEEDEEDEEEVEDDDDE---- >XP_043310239.1 high mobility group protein B1-like [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP KKP--RGKMSSYAFFVQ----TCRGEHKKQHPDASVNFSEFSKKCSERWKTMSAKEKGKF EDMAKADKARYEREMKTYIPPKGE--------TKKKFKDPNAPKRPPSAFFLFCSEYRPK IKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKG---KPD AAKK-GVVKAEK------------------------------------SKKKKEEEEDEE D-EEDEEEEEDEEDEEEEEDDDDE---- >XP_015828886.1 PREDICTED: high mobility group protein B2-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MTK----DP NKP--RGKTSAYAFFVA----TCREEHKKKHPGTSVNFAEFSKKCSERWKTMSAKEKVKF DEMAKTDKVRYDREMKTYVPPKGA-------KKGKKKKDPNAPKRPPSAFFVFCSDHRPR IKEENPGISIGDVAKKLGELWSTQGSKDKAPYEARAAKLKEKYEKDVAAYRAKGGSGKSD AGRKSGPGRPPA--------------------------------------KKAEPADDDD D-EDEDEEEDEDEEDDDDE--------- >tr|Q66IB6|Q66IB6_DANRE High mobility group box 2b OS=Danio rerio OX=7955 GN=hmgb2b PE=1 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MVKG---DV NKP--KGKTSAYAFFVQ----TCRDEHKRKSPDVPVNFSEFSKKCSERWKSLNASDKVKF EDMAKADKVRYDREMKTYVPPKGVG------KTGRKKKDPNAPKRPPSAFFVFCSEYRPT VKSEHPNLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGGG----- ASKR-GPGRPTG------------------------------------SVKKSQAEADDD D-DEDEDEEDEEDDEEEEDEDDE----- >NP_058883.1 high mobility group protein B2 [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDLAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE VGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEDDEDEEEEDEDEE---------- >XP_039265455.1 high mobility group protein B2-like [Styela clava] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKK---DP NKP--RGKMTAYAFFVQ----TCRQEHKKSHPDEQVVFAEFSRKCAERWKDMNTKEKKIF NDMAGRDKLRYDREMEGYCPPAGEG-----KKPQKRKKDPNAPKRPQSAFFLFCGDRRAE IKKENPSFTVGDIAKKLGKLWSEASKDIKEKYDDLGKLAKKQYEKDLKAYKD----GQQQ AGK---------------------------------------------AKKQKKEESSSS S-SSSSSSGSDSDRDSD----------- >CAA57212.1 unnamed protein product [Drosophila melanogaster] M----------------------------------------------------------- ------------------------------------ASSFPNPATTMAQV--VATSNAAG T---TGYDYRLNMAQA-------AAAAAVPGSQWWYSAANQGQVDANTAAQLQHQQQQQ- ----------------QQQQQQQQQ---QHQQQQQMQQQQQQQNVINSASPMSRV--KAD AKP--RGRMTAYAYFVQ----TCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRF HEMAEKDKQRYEAEMQNYVPPKGAVV--GRGKKRKQIKDPNAPKRSLSAFFWFCNDERNK VKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSA PSMQ------ASM----------------------------------QAQAQKAALLAAA A-QQQHQQLEEQHDDDDGDGDDDEN--Q >XP_026296431.1 high mobility group protein DSP1 [Apis mellifera] MSEHHRVAGGWGTASPGSREDASGGTAWWPSGLNTVSAEQQQQQQQQQQQQQNLHQHLMN QQQQQLTQQQQAQQQHHQDIVRSTAAATQQLFSYKMASSFQNPATTGTQSNPVSTSTPVG SCMRGGYDYRLGTGPGTGGGVPGTPSAPPPGVQWWYPGGVMDAGQNNLHQQLQGQQQQQH LSPITTQTSTPPVMSPHQIQQLSQQ---NNLQQNNAQSLQQRDN-------MPRG---KD SKP--RGRMTAYAFFVQ----TCRQEHKKKHPEEKIVFREFSKKCAMRWKTMSDKEKKRF HEMAEKDKKRYDAEMQNYTPPKGESK--GRGKKRKHIKDHNAPKRSLSAFFWFCNDERGK VKMLNPEFGVGDIAKELGKKWSDADPETKSKYEAMAEKDKARYEREMTAYKKKMKDGAPV VGVP-------A------------------------------------NTVKSDSEEEYK E-DDE----------------------- >XP_038054924.1 high mobility group protein 1 homolog isoform X1 [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGRK---DP NKP--KGRMSSYAFFVQ----FCREEHKERNPGQSVNFTQFSKKCSERWKTMDDGEKKRF LECADCDKMRYEREMARYVPPKGTK-----KRGRRKRKDPNAPKRNLSAFFLFSNDERSK VKAVHPDWGIGKIAQVLAEQWRNVSASQRAKYDKAAVQDKERYVKAMAEYKAKPVKKKSS SSSS-------S------------------------------------SSSSSSSSSSSS S-SDEE---------------------- >NP_999708.1 high mobility group protein 1 homolog [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKKD-RDS SKP--RGRMSAYAYFVQ----DSRAEHGKNHPNSPVRFAEFSKDCSARWKALEEKGKGVF HEKSMRDKVRYDREMQSYKPPKGEK-----NKRRRRRKDPDAPKRNLSAFFIFSGENRAA IKSVHPNWSVGDIAKELAVRWRAMTAGEKIPFDKGAAKDKERYIKAMAEYKAKAKPMKRQ VKES-------S------------------------------------SSSSSDSSSDDS S-SDDSD--------------------- >NP_001380091.1 High mobility group protein 1.2 [Caenorhabditis elegans] M----------------------------------------------------------- ------------------------------------------------------------ ---NSGYSANI------------FPSSSSP------------------------------ --------------------TLYQS---HQLQPNPSAT-------------MYQATPRDM GKPPVRGKTSPYGFFVK----MCYEEHKKKYPNENVQVTEISKKCSEKWKTMVDDEKRRF YELAQKDAERYQAEVAAYGGEDAMR------KRKRAKKDPHAPKRALSAFFFYSQDKRPE IQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKAEMQ----- ---------------------------------------------------KMSGMDHYD D-DNIHHVVHVEDINSQNIS-------- >CAE1251870.1 HMGB1 [Sepia pharaonis] M----------------------------------------------------------- -------------------------------F---------------------------- ------------------------------------------------------------ --------------------SRCQN--------------------------LRQL---KN TRY--DGRHIPPSQFINQAIWACKEEHERQHPGVKLDFTEFSRKCSEKWSTMVPEEINLF EVMAKKQKMRYETELASHMPPPVEQ----KKGKRKRVKDPNAPKRSLSAFFFFCKDERPK SIKENPSLKPSEVATMLGQKWKTISADVKGIYEKKAAKDKLRYKKEMAIFKSQQAKEALV VEKS--PPKPPSEDEEEEEEKEEEVVVPPPKVAKVVKQEIPVVNNQPESEEEEEEEDDDD D-DDDDSDDDDDDDDDDDDDDDDDDDRI >XP_031569961.1 high mobility group protein B1-like [Actinia tenebrosa] M----------------------------------------------------------- ------------------------------------------------------------ -----------------------------PK----------------------------- ---------------------------------------------------VSKK---DP NKP--KGAKSAYNFFLQ----D-QKEHMKGENGESLPLQEFSRSCADKWKNMSGEEKKPY TDKAEKDKTRYLKEMSSYSPPPAEEQNSGKKMKKKKIKDPNKPKKNLSAYMFFLADKRPS VKESLGDVSTTAVLKALGEMWSKTPESDKGEYQELAKKDRQRYDEEMKEYNNKTQ----- ---------GLS------------------------------------DGKKSVAVENGT A-TDD----------------------- >NP_032278.1 high mobility group protein B2 [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDLAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSENRPK IKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEEEDDEEEEEDEE---------- >NP_990817.1 high mobility group protein B2 [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKF EEMAKGDKARYDREMKNYVPPKGE-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKNDHPGLSIGDTAKKLGEMWSEQLAKDKQPYEQKAAKLKEKYEKDIAAYRAKS---KSD AGKK-GPGRPAG------------------------------------SKKKAEPEEEEE E-EEDEEEEEEEEDEE------------ >NP_999228.1 high mobility group protein B2 [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KGE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEDEDEEEEDEDEE---------- >XP_517538.3 high mobility group protein B2 [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEDEDEE---------- >XP_543194.2 high mobility group protein B2 [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEDEDDEEEEEDEE---------- >NP_001032705.1 high mobility group protein B2 [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEDEDEE---------- >XP_002709517.1 PREDICTED: high mobility group protein B2 [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEDEDDEEEDEDEE---------- >XP_003776594.1 high mobility group protein B2 [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEDEDEEEEDEDEE---------- >XP_010708063.1 high mobility group protein B2 [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKF EEMAKGDKARYDREMKNYVPPKGE-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKNDHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKS---KSD AGKK-GPGRPAG------------------------------------SKKKAEPEEEEE EEEEDEEEEEEEEDEE------------ >XP_003823467.1 high mobility group protein B2 [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEDEDEE---------- >XP_003984907.1 high mobility group protein B2 [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE EEEEEEDEDDEEEEEDEE---------- >XP_014948765.2 high mobility group protein B2 [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEEEDEE---------- >XP_004040680.1 high mobility group protein B2 [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE --EEEEDEDEEEEDEDEE---------- >XP_020555797.1 high mobility group protein B2 isoform X1 [Oryzias latipes] M----------------------------------------------------------- ------------------------------------------------------------ --------------------------KLPPASE--------------------------- ------------------ARSVAEK---ARLRQIEA---------------MTK----DP NKP--RGKTSAYAYFVA----TCREEHKKKHPGTSVNFAEFSKKCSERWKTMSSKEKVKF DELAKTDKARYDREMKTYVPPKGA-------KKVKKKKDPNAPKRPPSAFFVFCSDHRPK IKEDNPGISIGDIAKKLGELWATQSAKDKAPYEAKAAKLKEKYEKDVAAYRAKGGSGKSD AGKKSGPGRPAA--------------------------------------KKAVPVHDDD D-DDDEEDEDDEEDDDEDDDE------- >XP_005510965.1 high mobility group protein B2 [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKF EEMAKGDKARYDREMKNYVPPKGE-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKNDHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKS---KSD AGKK-GPGRPAG------------------------------------SKKKAEPEEEEE E-EEDEEEEEEDEDEE------------ >XP_017907305.1 PREDICTED: high mobility group protein B2 [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEEEDEE---------- >XP_006022293.1 high mobility group protein B2 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MSGKEKGKF EEMAKGDKARYDREMKNYVPPKGE-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKTEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDVAAYRAKS---KSD VGKK-GPGRPAG------------------------------------SKKKAEPEEEEE E-EEDEEEEEEEEEEDEE---------- >XP_006273433.1 PREDICTED: high mobility group protein B2 [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDSSVNFAEFSRKCSERWKTMSGKEKGKF EEMAKGDKARYDREMKNYVPPKGE-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKTEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKS---KSD AGKK-GPGRPAG------------------------------------SKKKAEPEEEEE E-EDDDDEEEEEEEDEE----------- >XP_020753973.1 high mobility group protein B2 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAFFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKF EDMAKSDKARYDREMKNYVPPKGD-------KKG-KKKDPNAPKRPPSAFFLFCSEHRPK IKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKG---KSE AGKK-GPGRPTG------------------------------------SKKKNEPEDEEE E-EEEEDEDEEEEEEDEE---------- >XP_030292285.1 high mobility group protein B2 [Sparus aurata] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MRK----DP KKP--RGKMTSYAYFVA----TCREEHKKKHPGAAVAFTEFSKKCSERWKTMSPKEKVKF EDMAKNDKIRYDQEMKSYVPPKGE-------KSKKKKKDPNAPKRPPSAFFVFCSDHRPR IKEENPGISIGDIAKKLGELWSTQSPKDKAPYSAKAAKLKEKYDKDVAVYRAKCGSGKSD AGKKSGPGRPSA--------------------------------------KKAEPVDDDD D-DDDDDDEEEDDEDDDDDEDDD----- >XP_040189311.1 high mobility group protein B2 [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MGKG---DP NKP--RGKMSSYAYFVQ----TCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKGKF EDLAKGDKVRYEREMKTYIPPKGE-------KAGKRKKDPNAPKRPPSAFFLFCSENRPQ IKTDTPGLSIGDTAKKLGELWSEQTPKDKQPFEQKAAKLKEKYEKDVAAYRAKG---TSD VGKK-IPGRPAS------------------------------------SKKKVEPEDDDD D-EDEDDEEDEDEDDDEDDE--------
BMGE Cleaned alignment of selected proteins >sp|P26583|HMGB2_HUMAN High mobility group protein B2 OS=Homo sapiens OX=9606 GN=HMGB2 PE=1 SV=2 DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >tr|B8JL29|B8JL29_DANRE High mobility group box 2a OS=Danio rerio OX=7955 GN=hmgb2a PE=1 SV=1 DPNKPRGKTSSYAFFVQTCREEHKKKNPGTSVNFSEFSKKCSERWRTMSSKEKGKFEEMAKTDKVRYDREMKNYVPPKGAKKKDPNAPKRPPSAFFVFCSDHRPKVKGDNPGISIGDIAKKLGEMWSKLSPKEKSPYEQKAMKLKEKYEKDVAAYRAKGKPDGAKKGPGRPAG--KKAEADDDDDEDEDEEDEEEEDEEDED >NP_001079576.1 high mobility group box 2 L homeolog [Xenopus laevis] DPNKPRGKMSSYAYFVQTCREEHKKKHPDTSVNFSDFSKKCSERWKSMSAKEKGKFEDLAKGDKARYEREMKTYIPPKGERKKDPNAPKRPPSAFFIFCSEHRPQIKSETPGLSIGDTAKKLGELWAEQTPKDKLPHEQKAAKLKEKYEKDVAAYRAKGKSDVGKKVPGRATGSKKKVEPHHHDDEEDEDEEDEEDEDDDDD >OWK05981.1 hypothetical protein Celaphus_00012630 [Cervus elaphus hippelaphus] DPNKPRGKMSPYAFSLQTCCEEH-KKHPDSSVNFAEFSKKCSERWKTMSTKEKPKFGDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKGPPSAFFLFCSEYCPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKGTAAYRAKGKSEAGKKGPGRPTGSKKKNEPQDEEEEEEEEDEDEEEEEEDEE >KAF4020859.1 hypothetical protein G4228_012444 [Cervus hanglu yarkandensis] DPNKPRGKMSPYAFSVQTCCEEH-KKHPDSSVNFAEFSKKCSERWKTMSTKEKPKFGDMAKSDKACYDREMKNYVPPKGDKKKDPNAPKGPPSAFFLFCSEYCPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKGTAAYRAKGKSEAGKKGPGRPTGSKKKNEPQDEEEEEEEEDEDEEEEEEDEE >KAB0344535.1 hypothetical protein FD754_021461 [Muntiacus muntjak] DPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDRQPYEKNAAKLKEKYEKDIAAYRAKGKPDAAKKRVVKAEKSKKKKEEEEDEEDEEDEEEEKDEEDEEEE >KAB0381219.1 hypothetical protein FD755_009003 [Muntiacus reevesi] DPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGEKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTATDDKQPYEKKAAKLKEKYEKEIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEV >XP_043310239.1 high mobility group protein B1-like [Cervus canadensis] DPKKPRGKMSSYAFFVQTCRGEHKKQHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGEKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEEEE >XP_015828886.1 PREDICTED: high mobility group protein B2-like [Nothobranchius furzeri] DPNKPRGKTSAYAFFVATCREEHKKKHPGTSVNFAEFSKKCSERWKTMSAKEKVKFDEMAKTDKVRYDREMKTYVPPKGAKKKDPNAPKRPPSAFFVFCSDHRPRIKEENPGISIGDVAKKLGELWSTQGSKDKAPYEARAAKLKEKYEKDVAAYRAKGKSDAGRKGPGRPPA--KKAEPADDDDDEDEDEEEDEDEEDDDD >tr|Q66IB6|Q66IB6_DANRE High mobility group box 2b OS=Danio rerio OX=7955 GN=hmgb2b PE=1 SV=1 DVNKPKGKTSAYAFFVQTCRDEHKRKSPDVPVNFSEFSKKCSERWKSLNASDKVKFEDMAKADKVRYDREMKTYVPPKGVKKKDPNAPKRPPSAFFVFCSEYRPTVKSEHPNLTIGEIAKKLGELWSKQSSKDRAPFEQKAGKLREKYEKEVAAYRAGG---ASKRGPGRPTGSVKKSQAEADDDDDEDEDEEDEEDDEEEE >NP_058883.1 high mobility group protein B2 [Rattus norvegicus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEVGKKGPGRPTGSKKKNEPEDEEEEEEEDDEDEEEEDEDEE >XP_039265455.1 high mobility group protein B2-like [Styela clava] DPNKPRGKMTAYAFFVQTCRQEHKKSHPDEQVVFAEFSRKCAERWKDMNTKEKKIFNDMAGRDKLRYDREMEGYCPPAGERKKDPNAPKRPQSAFFLFCGDRRAEIKKENPSFTVGDIAKKLGKLWSEASKDIKEKYDDLGKLAKKQYEKDLKAYKD--QQQAGK--------AKKQKKEESSSSSSSSSSSGSDSDRDSD- >CAA57212.1 unnamed protein product [Drosophila melanogaster] ADAKPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYEAEMQNYVPPKGAQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGMSAPSMQ-----ASAQAQKAALLAAAAQQQHQQLEEQHDDDDG >XP_026296431.1 high mobility group protein DSP1 [Apis mellifera] KDSKPRGRMTAYAFFVQTCRQEHKKKHPEEKIVFREFSKKCAMRWKTMSDKEKKRFHEMAEKDKKRYDAEMQNYTPPKGEHIKDHNAPKRSLSAFFWFCNDERGKVKMLNPEFGVGDIAKELGKKWSDADPETKSKYEAMAEKDKARYEREMTAYKKKMAPVVGVP------ANTVKSDSEEEYKEDDE------------- >XP_038054924.1 high mobility group protein 1 homolog isoform X1 [Patiria miniata] DPNKPKGRMSSYAFFVQFCREEHKERNPGQSVNFTQFSKKCSERWKTMDDGEKKRFLECADCDKMRYEREMARYVPPKGTKRKDPNAPKRNLSAFFLFSNDERSKVKAVHPDWGIGKIAQVLAEQWRNVSASQRAKYDKAAVQDKERYVKAMAEYKAKPKSSSSSS------SSSSSSSSSSSSSSSDEE------------ >NP_999708.1 high mobility group protein 1 homolog [Strongylocentrotus purpuratus] DSSKPRGRMSAYAYFVQDSRAEHGKNHPNSPVRFAEFSKDCSARWKALEEKGKGVFHEKSMRDKVRYDREMQSYKPPKGERRKDPDAPKRNLSAFFIFSGENRAAIKSVHPNWSVGDIAKELAVRWRAMTAGEKIPFDKGAAKDKERYIKAMAEYKAKAKRQVKES------SSSSSSDSSSDDSSSDDSD----------- >NP_001380091.1 High mobility group protein 1.2 [Caenorhabditis elegans] DMGKPRGKTSPYGFFVKMCYEEHKKKYPNENVQVTEISKKCSEKWKTMVDDEKRRFYELAQKDAERYQAEVAAYGGEDAMAKKDPHAPKRALSAFFFYSQDKRPEIQAGHPDWKVGQVAQELGKMWKLVPQETKDMYEQKAQADKDRYADEMRNYKAEM-----------------KMSGMDHYDDDNIHHVVHVEDINSQN >CAE1251870.1 HMGB1 [Sepia pharaonis] KNTRYDGRHIPPSQFINACKEEHERQHPGVKLDFTEFSRKCSEKWSTMVPEEINLFEVMAKKQKMRYETELASHMPPPVERVKDPNAPKRSLSAFFFFCKDERPKSIKENPSLKPSEVATMLGQKWKTISADVKGIYEKKAAKDKLRYKKEMAIFKSQQALVVEKS-PPKPPSSEEEEEEEDDDDDDDDDSDDDDDDDDDDD >XP_031569961.1 high mobility group protein B1-like [Actinia tenebrosa] DPNKPKGAKSAYNFFLQD-QKEHMKGENGESLPLQEFSRSCADKWKNMSGEEKKPYTDKAEKDKTRYLKEMSSYSPPPAEKIKDPNKPKKNLSAYMFFLADKRPSVKESLGDVSTTAVLKALGEMWSKTPESDKGEYQELAKKDRQRYDEEMKEYNNKT-----------GLSDGKKSVAVENGTATDD------------- >NP_032278.1 high mobility group protein B2 [Mus musculus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEDDEEEEEDEE >NP_990817.1 high mobility group protein B2 [Gallus gallus] DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQLAKDKQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEEEDEE-- >NP_999228.1 high mobility group protein B2 [Sus scrofa] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKGEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_517538.3 high mobility group protein B2 [Pan troglodytes] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_543194.2 high mobility group protein B2 [Canis lupus familiaris] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDDEEEEEDEE >NP_001032705.1 high mobility group protein B2 [Bos taurus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_002709517.1 PREDICTED: high mobility group protein B2 [Oryctolagus cuniculus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDDEEEDEDEE >XP_003776594.1 high mobility group protein B2 [Pongo abelii] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_010708063.1 high mobility group protein B2 [Meleagris gallopavo] DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEEEDEE-- >XP_003823467.1 high mobility group protein B2 [Pan paniscus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEDEDEE >XP_003984907.1 high mobility group protein B2 [Felis catus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDDEEEEEDEE >XP_014948765.2 high mobility group protein B2 [Ovis aries] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_004040680.1 high mobility group protein B2 [Gorilla gorilla gorilla] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEE-EEEEDEDEEEEDEDEE >XP_020555797.1 high mobility group protein B2 isoform X1 [Oryzias latipes] DPNKPRGKTSAYAYFVATCREEHKKKHPGTSVNFAEFSKKCSERWKTMSSKEKVKFDELAKTDKARYDREMKTYVPPKGAKKKDPNAPKRPPSAFFVFCSDHRPKIKEDNPGISIGDIAKKLGELWATQSAKDKAPYEAKAAKLKEKYEKDVAAYRAKGKSDAGKKGPGRPAA--KKAVPVHDDDDDDDEEDEDDEEDDDED >XP_005510965.1 high mobility group protein B2 [Columba livia] DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSSKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKKDPNAPKRPPSAFFLFCSEHRPKIKNDHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEDEDEE-- >XP_017907305.1 PREDICTED: high mobility group protein B2 [Capra hircus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_006022293.1 high mobility group protein B2 [Alligator sinensis] -----------------------------------------------MSGKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKKDPNAPKRPPSAFFLFCSEHRPKIKTEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDVAAYRAKSKSDVGKKGPGRPAGSKKKAEPEEEEEEEEDEEEEEEEEEEDEE >XP_006273433.1 PREDICTED: high mobility group protein B2 [Alligator mississippiensis] DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSRKCSERWKTMSGKEKGKFEEMAKGDKARYDREMKNYVPPKGEKKKDPNAPKRPPSAFFLFCSEHRPKIKTEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKSKSDAGKKGPGRPAGSKKKAEPEEEEEEEDDDDEEEEEEEDEE- >XP_020753973.1 high mobility group protein B2 [Odocoileus virginianus texanus] DPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYDREMKNYVPPKGDKKKDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEDEDEEEEEEDEE >XP_030292285.1 high mobility group protein B2 [Sparus aurata] DPKKPRGKMTSYAYFVATCREEHKKKHPGAAVAFTEFSKKCSERWKTMSPKEKVKFEDMAKNDKIRYDQEMKSYVPPKGEKKKDPNAPKRPPSAFFVFCSDHRPRIKEENPGISIGDIAKKLGELWSTQSPKDKAPYSAKAAKLKEKYDKDVAVYRAKCKSDAGKKGPGRPSA--KKAEPVDDDDDDDDDDDEEEDDEDDDD >XP_040189311.1 high mobility group protein B2 [Rana temporaria] DPNKPRGKMSSYAYFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKGKFEDLAKGDKVRYEREMKTYIPPKGERKKDPNAPKRPPSAFFLFCSENRPQIKTDTPGLSIGDTAKKLGELWSEQTPKDKQPFEQKAAKLKEKYEKDVAAYRAKGTSDVGKKIPGRPASSKKKVEPEDDDDDEDEDDEEDEDEDDDED
PhyML tree of selected proteins (tr_Q66IB6_Q66IB6_DANRE_High_mobility_group_box_2b_OS_Danio_rerio_OX_7955_GN_hmgb2b_PE_1_SV_1:0.28654341,(tr_B8JL29_B8JL29_DANRE_High_mobility_group_box_2a_OS_Danio_rerio_OX_7955_GN_hmgb2a_PE_1_SV_1:0.1209993,(XP_020555797_1_high_mobility_group_protein_B2_isoform_X1__Oryzias_latipes_:0.05532244,(XP_030292285_1_high_mobility_group_protein_B2__Sparus_aurata_:0.14918286,XP_015828886_1_PREDICTED__high_mobility_group_protein_B2_like__Nothobranchius_furzeri_:0.0638515):0.02535646):0.07114255):0.04027438,(((NP_001079576_1_high_mobility_group_box_2_L_homeolog__Xenopus_laevis_:0.10035481,XP_040189311_1_high_mobility_group_protein_B2__Rana_temporaria_:0.04817823):0.09939961,(((NP_058883_1_high_mobility_group_protein_B2__Rattus_norvegicus_:0.01564325,(XP_004040680_1_high_mobility_group_protein_B2__Gorilla_gorilla_gorilla_:0.00000001,((XP_003776594_1_high_mobility_group_protein_B2__Pongo_abelii_:0.00000001,(NP_001032705_1_high_mobility_group_protein_B2__Bos_taurus_:0.00000001,(XP_517538_3_high_mobility_group_protein_B2__Pan_troglodytes_:0.00000001,(sp_P26583_HMGB2_HUMAN_High_mobility_group_protein_B2_OS_Homo_sapiens_OX_9606_GN_HMGB2_PE_1_SV_2:0.00000001,XP_003823467_1_high_mobility_group_protein_B2__Pan_paniscus_:0.00000001):0.00000001):0.00000001):0.00000001):0.00000001,(NP_999228_1_high_mobility_group_protein_B2__Sus_scrofa_:0.00522297,(XP_002709517_1_PREDICTED__high_mobility_group_protein_B2__Oryctolagus_cuniculus_:0.00000001,(NP_032278_1_high_mobility_group_protein_B2__Mus_musculus_:0.02208771,((XP_543194_2_high_mobility_group_protein_B2__Canis_lupus_familiaris_:0.00000001,XP_003984907_1_high_mobility_group_protein_B2__Felis_catus_:0.00000001):0.00000001,((XP_017907305_1_PREDICTED__high_mobility_group_protein_B2__Capra_hircus_:0.00000001,(XP_014948765_2_high_mobility_group_protein_B2__Ovis_aries_:0.00000001,XP_020753973_1_high_mobility_group_protein_B2__Odocoileus_virginianus_texanus_:0.00000001):0.00000001):0.00000001,(OWK05981_1_hypothetical_protein_Celaphus_00012630__Cervus_elaphus_hippelaphus_:0.00530887,KAF4020859_1_hypothetical_protein_G4228_012444__Cervus_hanglu_yarkandensis_:0.00532732):0.06626388):0.00518548):0.00000001):0.00518421):0.00518433):0.00000001):0.00000001):0.00000001):0.05114976,((XP_006273433_1_PREDICTED__high_mobility_group_protein_B2__Alligator_mississippiensis_:0.0231848,XP_006022293_1_high_mobility_group_protein_B2__Alligator_sinensis_:0.01799283):0.0121667,(XP_010708063_1_high_mobility_group_protein_B2__Meleagris_gallopavo_:0.00000001,(NP_990817_1_high_mobility_group_protein_B2__Gallus_gallus_:0.00536723,XP_005510965_1_high_mobility_group_protein_B2__Columba_livia_:0.00531238):0.00000001):0.01374986):0.04019776):0.01525916,(XP_043310239_1_high_mobility_group_protein_B1_like__Cervus_canadensis_:0.01062514,(KAB0381219_1_hypothetical_protein_FD755_009003__Muntiacus_reevesi_:0.01602426,KAB0344535_1_hypothetical_protein_FD754_021461__Muntiacus_muntjak_:0.0267024):0.00000001):0.18639155):0.0451564):0.04069456,(XP_039265455_1_high_mobility_group_protein_B2_like__Styela_clava_:0.6733288,((NP_001380091_1_High_mobility_group_protein_1_2__Caenorhabditis_elegans_:1.10490937,(XP_038054924_1_high_mobility_group_protein_1_homolog_isoform_X1__Patiria_miniata_:0.32268744,NP_999708_1_high_mobility_group_protein_1_homolog__Strongylocentrotus_purpuratus_:0.49245087):0.20823047):0.05924801,(XP_031569961_1_high_mobility_group_protein_B1_like__Actinia_tenebrosa_:1.32255248,(CAE1251870_1_HMGB1__Sepia_pharaonis_:1.03860737,(CAA57212_1_unnamed_protein_product__Drosophila_melanogaster_:0.28432045,XP_026296431_1_high_mobility_group_protein_DSP1__Apis_mellifera_:0.1997436):0.25804151):0.09754635):0.01904701):0.1424993):0.24127477):0.03236347);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)