PB0055

DATABASE

Click here to access PB0055 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0055	P12814	Alpha-actinin-1	ACTN1	BDPLT15, actinin alpha 1	Homo_sapiens	F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.

Domains

Gene Ontology

PF00307 (2_CH) PF00435 (4_Spectrin) PF08726 (EFhand_Ca_insen)

GO:0005884 (colocalizes with) actin filament GO:0003725 (enables) double-stranded RNA binding GO:0003779 (enables) actin binding GO:0005178 (enables) integrin binding GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0005519 (enables) cytoskeletal regulatory protein binding GO:0017166 (enables) vinculin binding GO:0019904 (enables) protein domain specific binding GO:0030374 (enables) nuclear receptor coactivator activity GO:0042803 (enables) protein homodimerization activity GO:0044325 (enables) transmembrane transporter binding GO:0046872 (enables) metal ion binding GO:0051015 (enables) actin filament binding GO:0099186 (enables) structural constituent of postsynapse GO:0007015 (involved in) actin filament organization GO:0030036 (involved in) actin cytoskeleton organization GO:0036344 (involved in) platelet morphogenesis GO:0042981 (involved in) regulation of apoptotic process GO:0045893 (involved in) positive regulation of transcription, DNA-templated GO:0048041 (involved in) focal adhesion assembly GO:0051017 (involved in) actin filament bundle assembly GO:0051271 (involved in) negative regulation of cellular component movement GO:0051639 (involved in) actin filament network formation GO:0055001 (involved in) muscle cell development GO:0099173 (involved in) postsynapse organization GO:0098978 (is active in) glutamatergic synapse GO:0001725 (located in) stress fiber GO:0001726 (located in) ruffle GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005829 (located in) cytosol GO:0005856 (located in) cytoskeleton GO:0005886 (located in) plasma membrane GO:0005903 (located in) brush border GO:0005911 (located in) cell-cell junction GO:0005916 (located in) fascia adherens GO:0005925 (located in) focal adhesion GO:0016020 (located in) membrane GO:0030017 (located in) sarcomere GO:0030018 (located in) Z disc GO:0030054 (located in) cell junction GO:0030864 (located in) cortical actin cytoskeleton GO:0031093 (located in) platelet alpha granule lumen GO:0031143 (located in) pseudopodium GO:0042995 (located in) cell projection GO:0043197 (located in) dendritic spine GO:0070062 (located in) extracellular exosome

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >tr|B8JHU4|B8JHU4_DANRE Actinin, alpha 1 OS=Danio rerio OX=7955 GN=actn1 PE=1 SV=1 MDHHHHPQHHHHHQYDGGENDYMQQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGT QIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALGFIASKGVKLVSI GAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFH ISWKDGLGFCALIHRHRPELIDYNKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGT ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWI RRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGKMVSDISNSWGRLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWT DGKEEMLQHKDFETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELEYYDSP SVNARCQRICDQWDSLGVLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAME DLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGQN PYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKM EEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTM EHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEE FKACLISLGFDIGNDAQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVM ASFKVLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDSVPGALDYMSFSTALYGES DL
Selected proteins from model organisms >sp|P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2 MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR DGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNV KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFC ALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENR VPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRM VSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHT IEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEI NGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEM HGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGY DIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK NYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >tr|B8JHU4|B8JHU4_DANRE Actinin, alpha 1 OS=Danio rerio OX=7955 GN=actn1 PE=1 SV=1 MDHHHHPQHHHHHQYDGGENDYMQQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGT QIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALGFIASKGVKLVSI GAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFH ISWKDGLGFCALIHRHRPELIDYNKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGT ARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWI RRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGKMVSDISNSWGRLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWT DGKEEMLQHKDFETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELEYYDSP SVNARCQRICDQWDSLGVLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAME DLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGQN PYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKM EEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTM EHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEE FKACLISLGFDIGNDAQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVM ASFKVLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDSVPGALDYMSFSTALYGES DL >KAF4017596.1 hypothetical protein G4228_009207 [Cervus hanglu yarkandensis] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKP ERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAP YKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYR RLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFR QKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKIC DQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQAN VIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTAD QVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >OCT68674.1 hypothetical protein XELAEV_18039961mg [Xenopus laevis] MDHYDSQNIYMQQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLAKPER GKMRVHRISNVNKALDFIASKGVRLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYK NVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYV SSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRL HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEHAEKGYEEWMLNEIRRLERLDHLAEKFRQK ASIHEAWTDGKEVMLQKKDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNDRCQRICDE WDNLGALTQKRRDALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPEAD KERQAILGIQNEISKIMQTYHVNMSGSNPYTSITPQEINNKWDHVRQLVPRRDQALTEEHARQQQNERLRKQFAAQANVI GPWIQTKMQEIGRIAIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLESDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLT TIARTINEVENQVLTRDAKGITQDQMNEFRNSFNHFDRDHSGRLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPN RLGLVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITSDELRRELPPDQAEYCIARMAPYMGPDAVPGALDYMSF STALYGESDL >XP_015824660.1 PREDICTED: alpha-actinin-1 isoform X3 [Nothobranchius furzeri] MDSYDGDGNYMHQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPER GKMRVHKISNVNKALNFIASKGVKLVCIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYK NVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPMTNLNTAFEVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYV SSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRMPENTMQAMQQKLEDFRDYRRL HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQK AAIHEAWTEGKEDLLQKRDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQ WDSLGALSQKRNEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEAD KERMAILGIHNEIAKIVQTYHVNMAGTNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFATQANII GPWIQNKMQEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLT TIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGNDAQGENEFSRIMSIVDPN RMGIVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVPGALDYMSF STALYGESDL >XP_030299611.1 alpha-actinin-1 isoform X3 [Sparus aurata] MDQDQYDGDGNYMPQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKP ERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAP YKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMT YVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLATDLLEWIRRTIPWLENRLPENTMQAMQQKLEDFRDYR RLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFR QKAAIHEAWTEGKEEMLQKRDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRIC DQWDALGALTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPE ADKERQAILGIHNEIAKIVQTYHVNMAGTNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQAN VIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQL LTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIANDAQGENEFSRIMSIVD PNRMGIVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVPGALDYM SFSTALYGESDL >XP_023807396.1 alpha-actinin-1 isoform X5 [Oryzias latipes] MDHYDEDQDYRHPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPER GKMRVHKISNVNKALNFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYK NVNIQNFHISWKDGLGFCALIHRHRPELIDYAKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYV SSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRMPENTMQAMQQKLEDFRDYRRL HKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQK AAIHEAWTEGKEEMLQRRDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQ WDALGALSQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDSFIVHTIEEIQGLSTAHEQFKATLPEAD KERQAILGIHNEIAKIVQTYHVNMAGSNPYTTINPQEVNAKWDKVRQLVPLRDQSLIEEHARQQNNERLRRQFANQANVI GPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIINYKPKIDQLEGDHQLIQAALIFDNKHTNYTMEHIRVGWEQLLT TIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGNDAQGENEFSRIMSVVDPN RMGVVTFQGFIDFMSRETADTDTADQVMASFKILAGDKNYILADELRRELPPDQAEYCIARMAPYSGPDGVPGALDYMSF STALYGESDL >XP_043328307.1 alpha-actinin-1 isoform X2 [Cervus canadensis] MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDP LTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEK LASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMV SDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFE SDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPF NNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEIN GKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNY KPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRD HSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKN YITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_038968920.1 alpha-actinin-1 isoform X1 [Rattus norvegicus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYG ESDL >NP_598917.1 alpha-actinin-1 isoform 1 [Mus musculus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALI FDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDK NYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL >XP_015142743.1 alpha-actinin-1 isoform X2 [Gallus gallus] MDHHYDPQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLL EVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDI SVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAF DVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDY EKLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSN RPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGAL TQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLP DADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNE RLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEAL IFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPE EFKACLISLGYDIGNDAQKKTGMMDCEDFRACLISMGYNMGEAEFARIMSIVDPNRMGVVTFQAFIDFMS RETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALY GESDL >XP_016781746.1 alpha-actinin-1 isoform X1 [Pan troglodytes] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYG ESDL >XP_853103.1 alpha-actinin-1 isoform X5 [Canis lupus familiaris] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFAAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYSGPDAVPGALDYMSFSTALYG ESDL >XP_039253681.1 alpha-actinin-1-like isoform X1 [Styela clava] MSYQEPDENDYMAQEDQWDREGLLDPAWEKQQRKTFTAWCNSHLRKAGTQIEDIEKDFRNGLKLMLLLEVISGERLPKPD RGKMRFHKIANVNKALEFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEESSAKEGLLLWCQRKTAPY KNVNVQNFHMSWKDGLAFCALIHRHRPDLIDYDKLRKDDPLTNLNTAFDVADKYLDIPKMLDAEEMLEMAKPDEKAIMTY VSCYYHAFSGAQKTETAANRICKVLNVNQENERLMDEYERLASDLLEWINRMRPWLENRTTDNTMEGVQKKLDDFRDYRR HQKPPKAEEKGQLEAAFNTLQTKLRLSNRPAFMPSEGKMVSDIANAWKGLEGAEKGYEEWLLSEMRRLERLDHLAKKFYH KAQIHESWTDGKEAKLAEQDYRQCQLQDIKALIKKHDAFETDLAAHQDRVEQIAAIAQELNDLEYHDVATINDRCSTICE EWDRLGDATGKRREALLNIESCLEAIEKLNLEFAKRAAPFNIWMDGAMEDLEDMFIVHSNEEIKELIAAHEQFKATLSDA EQEKNVIMSLMADVEKHKRMYNLSQHIENVYTLLTPEKIDSKWQRVKELVPKRDNSLQMELAKQMNHERLRVEFATLANK VGPWITEKTDETVHMALNIKGSLENNLTSLKSYQQNIIAYQPNIDQLETINQKVQESLVYDNKHTTYTMEHIRVGWEHLK TTLTRTINEIENQILLRDAKGITEEQMNEFRSSFNHFDRDHSGQLNTDEMNGVLTSLGYDVNLKEPKGEAEFQRIMAVVD PNATGMVTFQSFIDFMTHENIDSDTADQVINSFRILAGDKPYITADELRRELPPDQAEYCIQRMSQWRGPDAPPGALDYE SFSTALYGESDL >NP_477484.2 alpha actinin, isoform A [Drosophila melanogaster] MMMENGLSMEYGDGYMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETL PKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRK TAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLQNTALPDERA VMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLNSRQADNSLAGVQKKLEEYR TYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQ KFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQ RICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKAT LGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAE KANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGW EQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGKDRQGDLDFQRILA VVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGAL DYMSFSTALYGETDL >XP_026299388.1 alpha-actinin, sarcomeric isoform X2 [Apis mellifera] MNDMEAYGDGYMEPEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIESIEEDFRNGLKLMLLLEVISGETLPRPD RGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPY KNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYNKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDMRNTAMPDERAVMTY VSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLLEWIRRTMPWLASRQTDNSLAGCQKKLEEYRTYRR KHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDINKAWKGLELAEKSFEEWLLSEMMRLERLEHLAQKFKH KADAHEEWTAGKEEMLTSQHFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDSASVNARCQRICD QWDRLGTLTQRRRQALDEAERILEKIDVLHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLMDAHAAFKATLGEA DKEYNAIVGLVREVESIVKQFQIPGGLENPYTTLTALDLTKKWSDVRQLVPQRDGTLQAELRKQQNNELLRRQFAEKANA VGPWIERQLDAVTAIGLGLQGTLEDQLHRLKEYEQAVYQYKVHLEELEKIHQAVQEGMIFENRYTQYTMETLRVGWEQLL TSINRNINEVENQILTRDSKGITQEQLNEFRSSFNHFDKNRTGRLAPDEFKSCLVSLGYSIGKDRQGDIDFQRILAIVDP NNSGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAGDKPYILADELRRELPPDQAEYCIQRMPPYKGPNAIPGALDYRS FSTALYGESDL >XP_038075921.1 alpha-actinin-4-like isoform X1 [Patiria miniata] MSLDEETYMEQEEDWDRSTVLDPMWEIQQTKTFTAWCNSHLRKSGTQIEHIDKDFCNGLKLINLLEVISGERLPKPEKGK MRVHKISNVQKALDYIMSKGVRLVSIGAEEIVDCNLKMTLGMIWTIILRFAIQDISVEESTAKEGLLLWCQRKTAPYNNV RVQNFHTSWKDGLAFCALIHRHRPDLLDYNSLSKDDPKKNLELAFEVAEKYLDIPKMLDPEDIINTAKPDERSIMTYVSC YYHAFAGAQQAENAANRLCKVLRMNQDNERLMDEYDRLASDLLEWIKRKRPWLEDRTLSENSLPAVQDKLDEFRNYRGKE KPPKTEEKGQLETNYNTLQTKLRLSNRPAYIPQEGKMVSDIAKAWKGLEQSERGFEDWLLAEMRRLERLDHLARKFRHKC EIHEGWAEGKEPDLENNDYSGIKLNEIYALKKKHEAFESDLAAHQDRVEQIAAIAQEMNLLEYHDIGPINSRCQTICDQW DRLGNLTSARRQTLETIQDLLQRVDSLFLDFAKKAAPFNNWMEGASEDLVDVFSVHTVDEIRGLIQPHEEFKATLNDAQS AFDELVEIGNKIKNLFAEHNLDIDKSNPYTTLTVQDIVSKWQEVLKLVPERDQALQSELLKQESNERLRYQFAKKANVVG PWIEGQTMKVNNLHMERGALEEHLASLQRIERDVVDYKAHMDELEMYNQSVQEAMIFENEHTKYTMETIRVGYEQLVTTT RRLINELENQILTRDSKGITEEQFEIFRQSFNIFDKNHSGKLDPMEFKSCLVSLSMAPPDDKSGRNPEFDRIMQSVDPNH DGHVTFEAFLDYMSREATDTDTSEQVKGSFKVLAGNKNYITKEDLMRELPPDQAEYCIARMAPYQGPDAIPGALDYLSFS TALYGESDL >XP_031561014.1 alpha-actinin-1-like [Actinia tenebrosa] MAEDEQEYYGYFYGEEDKGLLDPAWEKQQKKTFTAWCNSHLRKSGKAIETMEEDFRDGVLLLLLLESLSGDKLTAERGKL RFHRIANVNKALDFVASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDIAIEDSFAKDGLLLWCQRKTAPYKNVK VTNFHTSFKDGLAFCALIHRHRPDLIEYEKLRKDDPMTNLNTAFDVAETHLDIPKMLDPEDMIDNERPDERAVMTYVSSY YHALTSSQQADTAAKRIGKVLTINRDNEKMMEDYETLASDLMDWINKTLPRFKNRDSDGTLADMQKKLEELRNYRGGEKP PKVEDKGALETNFNTLQTKLRLSNRPAFLPTEGKMINDINDAWGNLEAAEKDFEDWLLTEMRRMERLDHLAQKFKHKCDI HEAWTDGKDVTLSRDDFSDASLPDILALMKKHEAFESDLAAHQDRVDQIVAIAQELNALEYSEIDKVNSRCQKICDNWKD LGELTMHRLQKLEETEQCLQQLDNLRLEFAKKAAPFNNWLESAREDLMDMFIVHTVEEIQELLDAHEAFKANMPAAENEY QAIIEIAEQIKQLSSQDNPYTSLTGEDIKTAWNEVLNLVPQRDASLREERSKQERNETLRIDFAKKANVVGPWIQQQGEN LRSIGFHMTGTLEKNLGLLQELETLIANYKPNMDELEAINQQVQQALIFENTHTKYTMEALRIGWEQLLTATARNINEVE NQILTRDSKGITEEQMKEFRASFNFFDKDENGKLEKHEFKQCLVSLGYNVKEGEKGDKEFERLMTIVDPNNTKKVTFQAF VDFMTRETADSDTAEQVMESFRILAGDKAYITAEELQRELPPDQAEYCIARMAPYEGKDAVPGALDYMSFSTALYGESDL >XP_797562.1 alpha-actinin isoform X1 [Strongylocentrotus purpuratus] MAYYGNQDAYAYDDDDEDDYMKQEDEWNRDEVLDPAWERQQRKTFTAWCNSHLRKANANIEEISSDFCNGLKLMMLLEVI SSEKLPPPERGKMRFHKIANVNKALDFITSKGVRLVSIGAEEIVDMNLKMILGMIWTIILRFAIQDISIEDHSAKEGLLL WCQRKTAPYRNVNIQNFHNSWKDGLGFCALIHRHRPDLLDYSKLKKDDPATNLELAFSVAEKHLDIPRMLDAEDLMNTAR PDDKSIMTYVSAYYHAFSGAQKAETAAGRINKVLGLNMENQRLMDEYEKLASDLLEWIRRKKPWLEDRTLQESTLDAMQK KLDEFRTYRGKEKPPKTEDKARLETNFNTLQTKLQLTNRPAYRPSEGKLVSDIAKAWKGLETSEKGFEDWLLAEMRRLER LDHLAKKFRHKCDIHEAWAAGKEEILREDFSGMRLNDLKAKCRKHEAFESDLAAHQDRVEQIAAIAQEMNDLEYHAIGPI NQRCQTICDQWDTLGSLSMGRSEALAKAVMILESIDSRQLDFAKKAAPFNNWLDGAREDLMDMFIVHTLEEISELLDAHE VFKNNLGAAEEEFNSLAALANEINKTIEMNNVGIKENPYTTLTVQVVVEKWRDLCELVPKRDEALSNELRRQQSNEQMRV RFAQLANQVGPWIEKQMAATMNIAIGLNVPLESQLHKLQDYEHTVLQYKSNVDDLESCNKSVQEAMIFENPHTQYTMETI RVGWEQLLTAIRRYINEIENNILTRDTKGITEEQLNEFRASFNHFDKNRTQRLEPLEFRSCLVSLGYDLREDKKSDIEFQ RIMALVDPSGTGKVSFQSFLDFMTREMSDADTVEQVVDSFKVLANGKAYILPDELRMELPPEQAEYCIARMAPFNGTGAA PGALDYMSFSSALYGQSEL >NP_506128.1 AcTiniN [Caenorhabditis elegans] MVDYYQQPPSYHQPGYDYTQQEEEWDREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDTIEEDFRNGLKLMLLLEVISG EPLPKPDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWTIILRFAIQDINVEELSARDGLLLWC QRKTAPYNNVNVQNFHNSWKDGLAFCALIHRHRPDLLDYSQLHKGDPIHNLNLAFDIAEKHLDIPKMLDAEDMANSQPDE KAVMTYVSCYYHYFSGMRKAETAANRICRVLKVNQENEKMMEDYENLASDLLAWINRWMPWLANRSTDDTLQQAQQKLED YRNYRRREKPPRIEDKGRLETLFNTLQTRLRLSNRPAFLPRDGHLIKDINAAWAGLEDSEKGFEEWLLSEIMRLERLEHL AEKFRRKCALHEEWAHGKEDALRSNDWRSCGLYKIKALRKRHEAFESDLGAHQDRVEQIAAIARELNNLRYPDIGPINAR CQAICSQWDRLGQLSSKRRETLEDAERIAERLDSLYLDFAKRAAPFNNWLDGAREDLADLVIVHEMREIEELVNAHDQFK STLGDADREFSSINQIEHEVEHLVTSHGLDRELLRNPYTDLSASDIRRKWGEVQNSVPRRDSQLQAELKRQQNNERLRTI FAEKANQVGPWLERELEQVLAIGLGGRGRLEDAIQQLRSIQRNVLGYKPNLDELERVHQEMQENFVFENRKSRYSMESLR VGWETLLTSINKTINEFENQVLLRDSKGISEEQIAEFRASFSHFDKERAGLDPEQLRSCLISVGYTIRPGREGDAELHRV LAHVDPNRMGRVPFEAFLDFMTKENSDQDTVEQMIDSFRILASGKTFITADELERELPRDQAAYCMARMAPSREPGAPPR SFDYVTFSRSLYSQ >XP_005212033.1 alpha-actinin-1 isoform X4 [Bos taurus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYG ESDL >XP_002719567.1 PREDICTED: alpha-actinin-1 isoform X1 [Oryctolagus cuniculus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRLPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNSRCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYG ESDL >XP_024087665.1 alpha-actinin-1 isoform X4 [Pongo abelii] MPGIPNERRWGEVWATRPGQWRASGGLCPFPPPPPASAHAALVCPPSSVCVEIRSKRPPRGRQSASPAAA VAASSSLRQQRRGGTGRRGASPAPPAQPSPTPSPRQGSSRCSERRWRKKSRPQHARTIMDHYDSQQTNDY MQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPER GKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLL WCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKML DAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRR TIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVS DINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKA LLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEK LLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIH NEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVI GPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEH IRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDI GNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVM ASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >NP_001229990.1 alpha-actinin-1 [Sus scrofa] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDD FRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITV DELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_031409431.1 alpha-actinin-1 isoform X1 [Meleagris gallopavo] MLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFA IQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNL NTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKVSQDPKLPPQSTPDIIGTLRP DEKAIMTYVSCYYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPE NTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQ AEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESD LAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLE YAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYH VNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEI GRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTT IARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDAQGEAEFA RIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIAR MAPYNGRDAVPGALDYMSFSTALYGESDL >XP_003824135.1 alpha-actinin-1 isoform X1 [Pan paniscus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYG ESDL >XP_019688751.1 alpha-actinin-1 isoform X1 [Felis catus] MCLGEAWSAREPGPWWLSEAALLSPHRRHASLIWLQVGYLVYSVAPPVEKAPLSTEASLVRSAKSGRPGL CTETFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIAS KGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHIS WKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYV SSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRAPENTMHAMQQK LEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWL LNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVE QIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFN NWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPY TTITPQEINSKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFAAQANVIGPWIQTKMEEIGRISIEMHG TLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVE NQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACL ISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRR ELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_027827748.1 alpha-actinin-1 isoform X1 [Ovis aries] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYG ESDL >XP_004055393.1 alpha-actinin-1 isoform X1 [Gorilla gorilla gorilla] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKETMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYG ESDL >XP_005502325.2 alpha-actinin-1 isoform X3 [Columba livia] MPSSTGFLLPEILTLQPTIPNSVSASPQLKASEVRGEQGDQAEQDTAEERTFTAWCNSHLRKAGTQIENI EEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLG MIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGK LRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKVSQDPKFPPQS TPDILGTLRPDAKAIMTYVSCYYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRT IPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSD INNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKAL LKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKL LETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHN EVSKIVQTYHVNMAGTNPYTTITPHEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIG PWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHI RVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDCEDFRACLISMGYTMG EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAE YCIARMAPYNGRDAVPGALDYMSFSTALYGESDL >XP_017909535.1 PREDICTED: alpha-actinin-1 isoform X3 [Capra hircus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYG ESDL >XP_006025253.1 alpha-actinin-1 isoform X1 [Alligator sinensis] MDHYDSQQTNDYMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGKMVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALMEEHARQQQNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDAQKKTGMMDSEDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVPGALDYMSFSTALYG ESDL >XP_006266503.1 PREDICTED: alpha-actinin-1 isoform X1 [Alligator mississippiensis] MDHYDSQQTNDYMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDLLEWIRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNR PAFMPSEGKMVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQK DYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPD ADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALMEEHARQQQNER LRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALI FDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEE FKACLISLGYDIGNDAQKKTGMMDSEDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSR ETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVPGALDYMSFSTALYG ESDL >XP_020745442.1 alpha-actinin-1 [Odocoileus virginianus texanus] MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDIS VEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFD VAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYE KLASDVGTPGFSWSGPGKALPPCPERPGSPQNPSIPPNPSLGTVPDWALPLVPAADRGRLGLSQKSGVVG GLGASRDFGELSSRLFLSPLYSCFPLRSKEDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQK ASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSV NARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIE EIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVP RRDQALTEEHTRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYK PKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFR ASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKTGMMDTDDFRACLISMGYNMGEAEFARIMSIVD PNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGP DAVPGALDYMSFSTALYGESDL >XP_040189308.1 alpha-actinin-1 isoform X1 [Rana temporaria] MMMDHYEGQHTNAAGDYMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKL MLLLEVISGERLAKPERGKMRVHKISNVNKALNFITGKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFA IQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPYTNL NTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRILKVLAVNQENEQL MEDYEKLASDLLEWIRRTIPWLEDRAPENTMQAMQQKLEDFRDYRRQHKPPKVQEKCQLEINFNTLQTKL RLSNRPAFMPSEGKMVSDINNAWGGLEQGEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEN MLQKKDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDN LGVLTQKRREALEKTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLGTAHEQFK ATLPEADKERQAILGIHNEVSKIAQTYHVNMAGTNPYSTILPIEINNKWDHVRQLVPRRDQALMEEHARQ QQNERLRKQFGAQANVIGPWIQTKMQEIGKISIEMNGTLEDQLSHLRQYEKNIVNYKPKIDQLESDHQQI QEALIFDNKHTNYTMEHTRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRNSFNHFDRDHNGT LGPEEFKACLISLGYDIGNDAQKKIGMLDSDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFI DFMSRETADTDTADQVVSSFKVLAGDKNYITADELRRELPPDQAEYCIARMAPYIGHDAVPGALDYMSFS TALYGESDL
Mafft alignment of selected proteins >sp|P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2 ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQ----------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVP GALDYMSFSTALYGESDL >tr|B8JHU4|B8JHU4_DANRE Actinin, alpha 1 OS=Danio rerio OX=7955 GN=actn1 PE=1 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ --------MD-HHHHPQHHHHHQYDGGE--N---DY-------MQQEDDWDRDMLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALGFIASKGVKLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYNKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDISNSWGRLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTDGKEEMLQH KDFETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELEYYDSPSVNARCQRI CDQWDSLGVLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMA-GQNPYTTINPQ EINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISI EMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEEFKACLISL GFDIG-NDAQ----------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDSVP GALDYMSFSTALYGESDL >KAF4017596.1 hypothetical protein G4228_009207 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR------------------ --------------------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >OCT68674.1 hypothetical protein XELAEV_18039961mg [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQ--N---IY-------MQQEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIDEDFRD GLKLMLLLEVISGERLAKPERGKMRVHRISNVNKALDFIASKGVRLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEHAEKGYEEWMLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEVMLQK KDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNDRCQRI CDEWDNLGALTQKRRDALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPEADKERQAILGIQNEISKIMQTYHVNMS-GSNPYTSITPQ EINNKWDHVRQLVPRRDQALTEEHARQQQNERLRKQFAAQANVIGPWIQTKMQEIGRIAI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLESDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQVLTRDAKGITQDQMNEFRNSFNHFDRDHSGRLGPEEFKACLISL GYDIG-NDPQ----------------------G-EAEFARIMSIVDPNRLGLVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITSDELRRELPPDQAEYCIARMAPYMGPDAVP GALDYMSFSTALYGESDL >XP_015824660.1 PREDICTED: alpha-actinin-1 isoform X3 [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-S-----------YD-GD--G---NY-------MHQEDDWDRDMLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFIASKGVKLVCIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPMTNLNTAFEVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--MPENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEDLLQK RDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRI CDQWDSLGALSQKRNEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLSTAHEQFKATLPEADKERMAILGIHNEIAKIVQTYHVNMA-GTNPYTTINPQ EINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFATQANIIGPWIQNKMQEIGRISI EMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISL GFDIG-NDAQ----------------------G-ENEFSRIMSIVDPNRMGIVTFQAFID FMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVP GALDYMSFSTALYGESDL >XP_030299611.1 alpha-actinin-1 isoform X3 [Sparus aurata] MD---------------------------------------------------------- ------------------------------------------------------------ --------QD-Q-----------YD-GD--G---NY-------MPQEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLATDL----LEWI--RRTIPWLENR--LPENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEEMLQK RDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRI CDQWDALGALTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMA-GTNPYTTINPQ EINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISI EMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISL GFDIA-NDAQ----------------------G-ENEFSRIMSIVDPNRMGIVTFQAFID FMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVP GALDYMSFSTALYGESDL >XP_023807396.1 alpha-actinin-1 isoform X5 [Oryzias latipes] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-ED--Q---DY-------RHPEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFIASKGVKLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYAKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--MPENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEEMLQR RDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRI CDQWDALGALSQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDSFIVH TIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMA-GSNPYTTINPQ EVNAKWDKVRQLVPLRDQSLIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISI EMHGTLEDQLTHLRQYEKSIINYKPKIDQLEGDHQLIQAALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISL GFDIG-NDAQ----------------------G-ENEFSRIMSVVDPNRMGVVTFQGFID FMSRETADTDTADQVMASFKILAGDKNYILADELRRELPPDQAEYCIARMAPYSGPDGVP GALDYMSFSTALYGESDL >XP_043328307.1 alpha-actinin-1 isoform X2 [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQ----------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_038968920.1 alpha-actinin-1 isoform X1 [Rattus norvegicus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVP GALDYMSFSTALYGESDL >NP_598917.1 alpha-actinin-1 isoform 1 [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQ----------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVP GALDYMSFSTALYGESDL >XP_015142743.1 alpha-actinin-1 isoform X2 [Gallus gallus] ------------------------------------------------------------ ------------------------------------------------------------ --------MDHH-----------YD-PQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDAQKKTGMMDCEDFRACLISMGYNMG-EAEFARIMSIVDPNRMGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVP GALDYMSFSTALYGESDL >XP_016781746.1 alpha-actinin-1 isoform X1 [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVP GALDYMSFSTALYGESDL >XP_853103.1 alpha-actinin-1 isoform X5 [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFAAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYSGPDAVP GALDYMSFSTALYGESDL >XP_039253681.1 alpha-actinin-1-like isoform X1 [Styela clava] ------------------------------------------------------------ ------------------------------------------------------------ --------MS-------------YQ-EPDEN---DY-------MAQEDQWDREGLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIEDIEKDFRN GLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALEFIASKGVKLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEESSAKEGLLLWCQRKTAPYKNVNVQNFHMSWKDGLAFCA LIHRHRPDLIDYDKLRKDDPLTNLNTAFDVADKYLDIPKMLDAEEMLEMAKPDEKAIMTY VSCY------------------------------------------YHAFSGAQKTETAA NRICKVLNVNQENERLMDEYERLASDL----LEWI--NRMRPWLENR--TTDNTMEGVQK KLDDFRDYRRHQKPPKAEEKGQLEA------------AFNTLQTKLRLSNRPAFMPSEGK MVSDIANAWKGLEGAEKGYEEWLLSEMRRLERLDHLAKKFYHKAQIHESWTDGKEAKLAE QDYRQCQLQDIKALIKKHDAFETDLAAHQDRVEQIAAIAQELNDLEYHDVATINDRCSTI CEEWDRLGDATGKRREALLNIESCLEAIEKLNLEFAKRAAPFNIWMDGAMEDLEDMFIVH SNEEIKELIAAHEQFKATLSDAEQEKNVIMSLMADVEKHKRMYNLSQH-IENVYTLLTPE KIDSKWQRVKELVPKRDNSLQMELAKQMNHERLRVEFATLANKVGPWITEKTDETVHMAL NIKGSLENNLTSLKSYQQNIIAYQPNIDQLETINQKVQESLVYDNKHTTYTMEHIRVGWE HLKTTLTRTINEIENQILLRDAKGITEEQMNEFRSSFNHFDRDHSGQLNTDEMNGVLTSL GYDVNLKEPK----------------------G-EAEFQRIMAVVDPNATGMVTFQSFID FMTHENIDSDTADQVINSFRILAGDKPYITADELRRELPPDQAEYCIQRMSQWRGPDAPP GALDYESFSTALYGESDL >NP_477484.2 alpha actinin, isoform A [Drosophila melanogaster] MM---------------------------------------------------------- ------------------------------------------------------------ --------ME-NGLSME------YG-----D---GY-------MEQEEEWEREGLLD--- ------PAWEKQQ-------------------KKTFTAWCNSHLRKAGTAIDNIEEDFRN GLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLK MTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCA LIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLQNTALPDERAVMTY VSSY------------------------------------------YHCFSGAQKAETAA NRICKVLKVNQENERLMEEYERLASDL----LEWI--RRTMPWLNSR--QADNSLAGVQK KLEEYRTYRRKHKPPRVEQKAKLET------------NFNTLQTKLRLSNRPAYLPTEGK TVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQS QDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRI CDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVH TMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGG-LENPYTTLTAN DMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGM GLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWE QLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSL GYSIG-KDRQ----------------------G-DLDFQRILAVVDPNNTGYVHFDAFLD FMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVP GALDYMSFSTALYGETDL >XP_026299388.1 alpha-actinin, sarcomeric isoform X2 [Apis mellifera] ------------------------------------------------------------ ------------------------------------------------------------ --------MN-D---MEA-----YG-----D---GY-------MEPEEEWEREGLLD--- ------PAWEKQQ-------------------KKTFTAWCNSHLRKAGTAIESIEEDFRN GLKLMLLLEVISGETLPRPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNLK MTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCA LIHRHRPDLIDYNKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDMRNTAMPDERAVMTY VSSY------------------------------------------YHCFSGAQKAETAA NRICKVLKVNQENERLMEEYERLASDL----LEWI--RRTMPWLASR--QTDNSLAGCQK KLEEYRTYRRKHKPPRVEQKAKLET------------NFNTLQTKLRLSNRPAYMPTEGK MVSDINKAWKGLELAEKSFEEWLLSEMMRLERLEHLAQKFKHKADAHEEWTAGKEEMLTS QHFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDSASVNARCQRI CDQWDRLGTLTQRRRQALDEAERILEKIDVLHLEFAKRAAPFNNWLDGTREDLVDMFIVH TMEEIQGLMDAHAAFKATLGEADKEYNAIVGLVREVESIVKQFQIPGG-LENPYTTLTAL DLTKKWSDVRQLVPQRDGTLQAELRKQQNNELLRRQFAEKANAVGPWIERQLDAVTAIGL GLQGTLEDQLHRLKEYEQAVYQYKVHLEELEKIHQAVQEGMIFENRYTQYTMETLRVGWE QLLTSINRNINEVENQILTRDSKGITQEQLNEFRSSFNHFDKNRTGRLAPDEFKSCLVSL GYSIG-KDRQ----------------------G-DIDFQRILAIVDPNNSGYVHFDAFLD FMTRESTDTDTAEQVIDSFRILAGDKPYILADELRRELPPDQAEYCIQRMPPYKGPNAIP GALDYRSFSTALYGESDL >XP_038075921.1 alpha-actinin-4-like isoform X1 [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ --------MS-----------------LDEE---TY-------MEQEEDWDRSTVLD--- ------PMWEIQQ-------------------TKTFTAWCNSHLRKSGTQIEHIDKDFCN GLKLINLLEVISGERLPKPEKGKMRVHKISNVQKALDYIMSKGVRLVSIGAEEIVDCNLK MTLGMIWTIILRFAIQDISVEESTAKEGLLLWCQRKTAPYNNVRVQNFHTSWKDGLAFCA LIHRHRPDLLDYNSLSKDDPKKNLELAFEVAEKYLDIPKMLDPEDIINTAKPDERSIMTY VSCY------------------------------------------YHAFAGAQQAENAA NRLCKVLRMNQDNERLMDEYDRLASDL----LEWI--KRKRPWLEDR-TLSENSLPAVQD KLDEFRNYRGKEKPPKTEEKGQLET------------NYNTLQTKLRLSNRPAYIPQEGK MVSDIAKAWKGLEQSERGFEDWLLAEMRRLERLDHLARKFRHKCEIHEGWAEGKEPDLEN NDYSGIKLNEIYALKKKHEAFESDLAAHQDRVEQIAAIAQEMNLLEYHDIGPINSRCQTI CDQWDRLGNLTSARRQTLETIQDLLQRVDSLFLDFAKKAAPFNNWMEGASEDLVDVFSVH TVDEIRGLIQPHEEFKATLNDAQSAFDELVEIGNKIKNLFAEHNLDID-KSNPYTTLTVQ DIVSKWQEVLKLVPERDQALQSELLKQESNERLRYQFAKKANVVGPWIEGQTMKVNNLHM E-RGALEEHLASLQRIERDVVDYKAHMDELEMYNQSVQEAMIFENEHTKYTMETIRVGYE QLVTTTRRLINELENQILTRDSKGITEEQFEIFRQSFNIFDKNHSGKLDPMEFKSCLVSL SMAPP-DDKS----------------------GRNPEFDRIMQSVDPNHDGHVTFEAFLD YMSREATDTDTSEQVKGSFKVLAGNKNYITKEDLMRELPPDQAEYCIARMAPYQGPDAIP GALDYLSFSTALYGESDL >XP_031561014.1 alpha-actinin-1-like [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ --------MA-------------ED-EQEYY---GY-------FYGEED---KGLLD--- ------PAWEKQQ-------------------KKTFTAWCNSHLRKSGKAIETMEEDFRD GVLLLLLLESLSGDKL-TAERGKLRFHRIANVNKALDFVASKGVKLVSIGAEEIVDGNLK MTLGMIWTIILRFAIQDIAIEDSFAKDGLLLWCQRKTAPYKNVKVTNFHTSFKDGLAFCA LIHRHRPDLIEYEKLRKDDPMTNLNTAFDVAETHLDIPKMLDPEDMIDNERPDERAVMTY VSSY------------------------------------------YHALTSSQQADTAA KRIGKVLTINRDNEKMMEDYETLASDL----MDWI--NKTLPRFKNR--DSDGTLADMQK KLEELRNYRGGEKPPKVEDKGALET------------NFNTLQTKLRLSNRPAFLPTEGK MINDINDAWGNLEAAEKDFEDWLLTEMRRMERLDHLAQKFKHKCDIHEAWTDGKDVTLSR DDFSDASLPDILALMKKHEAFESDLAAHQDRVDQIVAIAQELNALEYSEIDKVNSRCQKI CDNWKDLGELTMHRLQKLEETEQCLQQLDNLRLEFAKKAAPFNNWLESAREDLMDMFIVH TVEEIQELLDAHEAFKANMPAAENEYQAIIEIAEQIKQLSS--------QDNPYTSLTGE DIKTAWNEVLNLVPQRDASLREERSKQERNETLRIDFAKKANVVGPWIQQQGENLRSIGF HMTGTLEKNLGLLQELETLIANYKPNMDELEAINQQVQQALIFENTHTKYTMEALRIGWE QLLTATARNINEVENQILTRDSKGITEEQMKEFRASFNFFDKDENGKLEKHEFKQCLVSL GYNVK-EGEK----------------------G-DKEFERLMTIVDPNNTKKVTFQAFVD FMTRETADSDTAEQVMESFRILAGDKAYITAEELQRELPPDQAEYCIARMAPYEGKDAVP GALDYMSFSTALYGESDL >XP_797562.1 alpha-actinin isoform X1 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ------------------------------------------------------------ --------MA-YYGNQDAYA---YD-DDDED---DY-------MKQEDEWNRDEVLD--- ------PAWERQQ-------------------RKTFTAWCNSHLRKANANIEEISSDFCN GLKLMMLLEVISSEKLPPPERGKMRFHKIANVNKALDFITSKGVRLVSIGAEEIVDMNLK MILGMIWTIILRFAIQDISIEDHSAKEGLLLWCQRKTAPYRNVNIQNFHNSWKDGLGFCA LIHRHRPDLLDYSKLKKDDPATNLELAFSVAEKHLDIPRMLDAEDLMNTARPDDKSIMTY VSAY------------------------------------------YHAFSGAQKAETAA GRINKVLGLNMENQRLMDEYEKLASDL----LEWI--RRKKPWLEDR-TLQESTLDAMQK KLDEFRTYRGKEKPPKTEDKARLET------------NFNTLQTKLQLTNRPAYRPSEGK LVSDIAKAWKGLETSEKGFEDWLLAEMRRLERLDHLAKKFRHKCDIHEAWAAGKEEILR- EDFSGMRLNDLKAKCRKHEAFESDLAAHQDRVEQIAAIAQEMNDLEYHAIGPINQRCQTI CDQWDTLGSLSMGRSEALAKAVMILESIDSRQLDFAKKAAPFNNWLDGAREDLMDMFIVH TLEEISELLDAHEVFKNNLGAAEEEFNSLAALANEINKTIEMNNVGI--KENPYTTLTVQ VVVEKWRDLCELVPKRDEALSNELRRQQSNEQMRVRFAQLANQVGPWIEKQMAATMNIAI GLNVPLESQLHKLQDYEHTVLQYKSNVDDLESCNKSVQEAMIFENPHTQYTMETIRVGWE QLLTAIRRYINEIENNILTRDTKGITEEQLNEFRASFNHFDKNRTQRLEPLEFRSCLVSL GYDLR-EDKK----------------------S-DIEFQRIMALVDPSGTGKVSFQSFLD FMTREMSDADTVEQVVDSFKVLANGKAYILPDELRMELPPEQAEYCIARMAPFNGTGAAP GALDYMSFSSALYGQSEL >NP_506128.1 AcTiniN [Caenorhabditis elegans] M----------------------------------------------------------- ------------------------------------------------------------ --------VD-YYQQPPS-----YH--QPGY---DY-------TQQEEEWDREGLLD--- ------PAWEKQQ-------------------KKTFTAWCNSHLRKAGTSIDTIEEDFRN GLKLMLLLEVISGEPLPKPDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVK MTLGLIWTIILRFAIQDINVEELSARDGLLLWCQRKTAPYNNVNVQNFHNSWKDGLAFCA LIHRHRPDLLDYSQLHKGDPIHNLNLAFDIAEKHLDIPKMLDAEDMAN-SQPDEKAVMTY VSCY------------------------------------------YHYFSGMRKAETAA NRICRVLKVNQENEKMMEDYENLASDL----LAWI--NRWMPWLANR--STDDTLQQAQQ KLEDYRNYRRREKPPRIEDKGRLET------------LFNTLQTRLRLSNRPAFLPRDGH LIKDINAAWAGLEDSEKGFEEWLLSEIMRLERLEHLAEKFRRKCALHEEWAHGKEDALRS NDWRSCGLYKIKALRKRHEAFESDLGAHQDRVEQIAAIARELNNLRYPDIGPINARCQAI CSQWDRLGQLSSKRRETLEDAERIAERLDSLYLDFAKRAAPFNNWLDGAREDLADLVIVH EMREIEELVNAHDQFKSTLGDADREFSSINQIEHEVEHLVTSHGLDRELLRNPYTDLSAS DIRRKWGEVQNSVPRRDSQLQAELKRQQNNERLRTIFAEKANQVGPWLERELEQVLAIGL GGRGRLEDAIQQLRSIQRNVLGYKPNLDELERVHQEMQENFVFENRKSRYSMESLRVGWE TLLTSINKTINEFENQVLLRDSKGISEEQIAEFRASFSHFDKERAG-LDPEQLRSCLISV GYTIR-PGRE----------------------G-DAELHRVLAHVDPNRMGRVPFEAFLD FMTKENSDQDTVEQMIDSFRILASGKTFITADELERELPRDQAAYCMARMAPSREPGAPP RSFDYVTFSRSLYSQ--- >XP_005212033.1 alpha-actinin-1 isoform X4 [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_002719567.1 PREDICTED: alpha-actinin-1 isoform X1 [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--LPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNSRCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_024087665.1 alpha-actinin-1 isoform X4 [Pongo abelii] MPGIPNERRWGEVWATRPGQWRASGGLCPFPPPPPASAHAALVCPPSSVCVEIRSKRPPR GRQSASPAAAVAASSSLRQQRRGGTGRRGASPAPPAQPSPTPSPRQGSSRCSERRWRKKS RPQHARTIMD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVP GALDYMSFSTALYGESDL >NP_001229990.1 alpha-actinin-1 [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR------------------ ----------KKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_031409431.1 alpha-actinin-1 isoform X1 [Meleagris gallopavo] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----MLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSFYHAFSGAQKVSQDPKLPPQSTPDIIGTLRPDEKAIMTYVSCYYHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDAQ----------------------G-EAEFARIMSIVDPNRMGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVP GALDYMSFSTALYGESDL >XP_003824135.1 alpha-actinin-1 isoform X1 [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVP GALDYMSFSTALYGESDL >XP_019688751.1 alpha-actinin-1 isoform X1 [Felis catus] MC---------------------------------------------------------- ------------------------------------------------------------ --------LGEA-----------WS-AREPG---PWWLSEAALLSPHRRHASLIWLQVGY LVYSVAPPVEKAPLSTEASLVRSAKSGRPGLCTETFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINSKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFAAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_027827748.1 alpha-actinin-1 isoform X1 [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWEHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_004055393.1 alpha-actinin-1 isoform X1 [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--VPENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKETMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVP GALDYMSFSTALYGESDL >XP_005502325.2 alpha-actinin-1 isoform X3 [Columba livia] MPS-------------------STGFLLP----------------------EILTLQP-- ---------------------------------------TIPN----------------- -------SVSAS-----------PQ-LKASE---VR-------GEQGDQAEQ-------- ---------DTAE-------------------ERTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSFYHAFSGAQKVSQDPKFPPQSTPDILGTLRPDAKAIMTYVSCYYHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPH EINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDCEDFRACLISM GYTM----------------------------G-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVP GALDYMSFSTALYGESDL >XP_017909535.1 PREDICTED: alpha-actinin-1 isoform X3 [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMHAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGR MVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_006025253.1 alpha-actinin-1 isoform X1 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDAQKKTGMMDSEDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVP GALDYMSFSTALYGESDL >XP_006266503.1 PREDICTED: alpha-actinin-1 isoform X1 [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLENR--APENTMQAMQQ KLEDFRDYRRLHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDAQKKTGMMDSEDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVP GALDYMSFSTALYGESDL >XP_020745442.1 alpha-actinin-1 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ --------MD-H-----------YD-SQQTN---DY-------MQPEEDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIEEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRICKVLAVNQENEQLMEDYEKLASDVGTPGFSWSGPGKALPPCPERPGSPQNPSIPPNP SLGTVPDWALPLVPAADRGRLGLSQKSGVVGGLGASRDFGELSSRLFLSPLYSCFPLRSK --EDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQ KDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMA-GTNPYTTITPQ EINGKWDHVRQLVPRRDQALTEEHTRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISI EMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISL GYDIG-NDPQKKTGMMDTDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVP GALDYMSFSTALYGESDL >XP_040189308.1 alpha-actinin-1 isoform X1 [Rana temporaria] MM---------------------------------------------------------- ------------------------------------------------------------ --------MD-H-----------YE-GQHTNAAGDY-------MQPEDDWDRDLLLD--- ------PAWEKQQ-------------------RKTFTAWCNSHLRKAGTQIENIDEDFRD GLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFITGKGVKLVSIGAEEIVDGNAK MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCA LIHRHRPELIDYGKLRKDDPYTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTY VSSF------------------------------------------YHAFSGAQKAETAA NRILKVLAVNQENEQLMEDYEKLASDL----LEWI--RRTIPWLEDR--APENTMQAMQQ KLEDFRDYRRQHKPPKVQEKCQLEI------------NFNTLQTKLRLSNRPAFMPSEGK MVSDINNAWGGLEQGEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKENMLQK KDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKI CDQWDNLGVLTQKRREALEKTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVH TIEEIQGLGTAHEQFKATLPEADKERQAILGIHNEVSKIAQTYHVNMA-GTNPYSTILPI EINNKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMQEIGKISI EMNGTLEDQLSHLRQYEKNIVNYKPKIDQLESDHQQIQEALIFDNKHTNYTMEHTRVGWE QLLTTIARTINEVENQILTRDAKGISQEQMNEFRNSFNHFDRDHNGTLGPEEFKACLISL GYDIG-NDAQKKIGMLDSDDFRACLISMGYNMG-EAEFARIMSIVDPNRLGVVTFQAFID FMSRETADTDTADQVVSSFKVLAGDKNYITADELRRELPPDQAEYCIARMAPYIGHDAVP GALDYMSFSTALYGESDL
BMGE Cleaned alignment of selected proteins >sp|P12814|ACTN1_HUMAN Alpha-actinin-1 OS=Homo sapiens OX=9606 GN=ACTN1 PE=1 SV=2 SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >tr|B8JHU4|B8JHU4_DANRE Actinin, alpha 1 OS=Danio rerio OX=7955 GN=actn1 PE=1 SV=1 GE--NMQQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALGFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYNKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDISNSWGRLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTDGKEEMLQHKDFETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELEYYDSPSVNARCQRICDQWDSLGVLTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGQNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMTPYSGPDSVPGALDYMSFSTALYGESDL >KAF4017596.1 hypothetical protein G4228_009207 [Cervus hanglu yarkandensis] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR-----------------------EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >OCT68674.1 hypothetical protein XELAEV_18039961mg [Xenopus laevis] SQ--NMQQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLAKPERGKMRVHRISNVNKALDFIASKGVRLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEHAEKGYEEWMLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEVMLQKKDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNDRCQRICDEWDNLGALTQKRRDALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPEADKERQAILGIQNEISKIMQTYHVNMSGSNPYTSITPQEINNKWDHVRQLVPRRDQALTEEHARQQQNERLRKQFAAQANVIGPWIQTKMQEIGRIAIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLESDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQVLTRDAKGITQDQMNEFRNSFNHFDRDHSGRLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGLVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITSDELRRELPPDQAEYCIARMAPYMGPDAVPGALDYMSFSTALYGESDL >XP_015824660.1 PREDICTED: alpha-actinin-1 isoform X3 [Nothobranchius furzeri] GD--GMHQEDDWDRDMLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFIASKGVKLVCIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPMTNLNTAFEVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRMPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEDLLQKRDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQWDSLGALSQKRNEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERMAILGIHNEIAKIVQTYHVNMAGTNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFATQANIIGPWIQNKMQEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGENEFSRIMSIVDPNRMGIVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVPGALDYMSFSTALYGESDL >XP_030299611.1 alpha-actinin-1 isoform X3 [Sparus aurata] GD--GMPQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLATDLRRTIPWLENRLPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGNLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEEMLQKRDYETASLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQWDALGALTQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGTNPYTTINPQEINAKWDKVRQLVPQRDQALIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIAENEFSRIMSIVDPNRMGIVTFQAFIDFMSRETADTDTADQVMASFKVLAGDKNYILADELRRELPPDQAEYCIARMAPYTGPDGVPGALDYMSFSTALYGESDL >XP_023807396.1 alpha-actinin-1 isoform X5 [Oryzias latipes] ED--QRHPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYAKLRKDDPMTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRMPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEGAEKGYEEWLLNEIRRLERLDHLAEKFRQKAAIHEAWTEGKEEMLQRRDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQRICDQWDALGALSQKRSEALQRTEKLLETIDQLYLEFAKRAAPFNNWMEGAMEDLQDSFIVHTIEEIQGLSTAHEQFKATLPEADKERQAILGIHNEIAKIVQTYHVNMAGSNPYTTINPQEVNAKWDKVRQLVPLRDQSLIEEHARQQNNERLRRQFANQANVIGPWIQTKMEEIGRISIEMHGTLEDQLTHLRQYEKSIINYKPKIDQLEGDHQLIQAALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEIENQILTRDAKGISQEQLNEFRASFNHFDRDHSGTLGAEEFKACLISLGFDIGENEFSRIMSVVDPNRMGVVTFQGFIDFMSRETADTDTADQVMASFKILAGDKNYILADELRRELPPDQAEYCIARMAPYSGPDGVPGALDYMSFSTALYGESDL >XP_043328307.1 alpha-actinin-1 isoform X2 [Cervus canadensis] ------------------------------------------------------------------------------------------------------------------MTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_038968920.1 alpha-actinin-1 isoform X1 [Rattus norvegicus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHSRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITGDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL >NP_598917.1 alpha-actinin-1 isoform 1 [Mus musculus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL >XP_015142743.1 alpha-actinin-1 isoform X2 [Gallus gallus] PQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL >XP_016781746.1 alpha-actinin-1 isoform X1 [Pan troglodytes] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >XP_853103.1 alpha-actinin-1 isoform X5 [Canis lupus familiaris] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFAAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYSGPDAVPGALDYMSFSTALYGESDL >XP_039253681.1 alpha-actinin-1-like isoform X1 [Styela clava] EPDENMAQEDQWDREGLLDPAWEKQQRKTFTAWCNSHLRKAGTQIEDIEKDFRNGLKLMLLLEVISGERLPKPDRGKMRFHKIANVNKALEFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEESSAKEGLLLWCQRKTAPYKNVNVQNFHMSWKDGLAFCALIHRHRPDLIDYDKLRKDDPLTNLNTAFDVADKYLDIPKMLDAEEMLEMAKPDEKAIMTYVSCYYHAFSGAQKTETAANRICKVLNVNQENERLMDEYERLASDLNRMRPWLENRTTDNTMEGVQKKLDDFRDYRRHQKPPKAEEKGQLEAAFNTLQTKLRLSNRPAFMPSEGKMVSDIANAWKGLEGAEKGYEEWLLSEMRRLERLDHLAKKFYHKAQIHESWTDGKEAKLAEQDYRQCQLQDIKALIKKHDAFETDLAAHQDRVEQIAAIAQELNDLEYHDVATINDRCSTICEEWDRLGDATGKRREALLNIESCLEAIEKLNLEFAKRAAPFNIWMDGAMEDLEDMFIVHSNEEIKELIAAHEQFKATLSDAEQEKNVIMSLMADVEKHKRMYNLSQHIENVYTLLTPEKIDSKWQRVKELVPKRDNSLQMELAKQMNHERLRVEFATLANKVGPWITEKTDETVHMALNIKGSLENNLTSLKSYQQNIIAYQPNIDQLETINQKVQESLVYDNKHTTYTMEHIRVGWEHLKTTLTRTINEIENQILLRDAKGITEEQMNEFRSSFNHFDRDHSGQLNTDEMNGVLTSLGYDVNEAEFQRIMAVVDPNATGMVTFQSFIDFMTHENIDSDTADQVINSFRILAGDKPYITADELRRELPPDQAEYCIQRMSQWRGPDAPPGALDYESFSTALYGESDL >NP_477484.2 alpha actinin, isoform A [Drosophila melanogaster] ----DMEQEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIDNIEEDFRNGLKLMLLLEVISGETLPKPDRGKMRFHKIANVNKALDFIASKGVHLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYAKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDLQNTALPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLRRTMPWLNSRQADNSLAGVQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYLPTEGKTVSDISNSWKGLELAEKAFEEWLLAETMRLERLEHLAQKFKHKADAHEDWTRGKEEMLQSQDFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDCVSVNARCQRICDQWDRLGALTQRRRTALDEAERILEKIDILHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLIQAHDQFKATLGEADKEFNLIVNLVREVESIVKQHQIPGGLENPYTTLTANDMTRKWSDVRQLVPQRDQTLANELRKQQNNEMLRRQFAEKANIVGPWIERQMDAVTAIGMGLQGSLEDQLHRLKEYEQAVYAYKPNIEELEKIHQAVQESMIFENRYTNYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGISQEQLNEFRSSFNHFDKNRTGRLSPEEFKSCLVSLGYSIGDLDFQRILAVVDPNNTGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAADKPYILPDELRRELPPDQAEYCIQRMPPYKGPNGVPGALDYMSFSTALYGETDL >XP_026299388.1 alpha-actinin, sarcomeric isoform X2 [Apis mellifera] ----DMEPEEEWEREGLLDPAWEKQQKKTFTAWCNSHLRKAGTAIESIEEDFRNGLKLMLLLEVISGETLPRPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEEMTAKEGLLLWCQRKTAPYKNVNVQNFHLSFKDGLAFCALIHRHRPDLIDYNKLSKDNPLENLNTAFDVAEKYLDIPRMLDPDDMRNTAMPDERAVMTYVSSYYHCFSGAQKAETAANRICKVLKVNQENERLMEEYERLASDLRRTMPWLASRQTDNSLAGCQKKLEEYRTYRRKHKPPRVEQKAKLETNFNTLQTKLRLSNRPAYMPTEGKMVSDINKAWKGLELAEKSFEEWLLSEMMRLERLEHLAQKFKHKADAHEEWTAGKEEMLTSQHFRQCKLNELKALKKKHEAFESDLAAHQDRVEQIAAIAQELNTLEYHDSASVNARCQRICDQWDRLGTLTQRRRQALDEAERILEKIDVLHLEFAKRAAPFNNWLDGTREDLVDMFIVHTMEEIQGLMDAHAAFKATLGEADKEYNAIVGLVREVESIVKQFQIPGGLENPYTTLTALDLTKKWSDVRQLVPQRDGTLQAELRKQQNNELLRRQFAEKANAVGPWIERQLDAVTAIGLGLQGTLEDQLHRLKEYEQAVYQYKVHLEELEKIHQAVQEGMIFENRYTQYTMETLRVGWEQLLTSINRNINEVENQILTRDSKGITQEQLNEFRSSFNHFDKNRTGRLAPDEFKSCLVSLGYSIGDIDFQRILAIVDPNNSGYVHFDAFLDFMTRESTDTDTAEQVIDSFRILAGDKPYILADELRRELPPDQAEYCIQRMPPYKGPNAIPGALDYRSFSTALYGESDL >XP_038075921.1 alpha-actinin-4-like isoform X1 [Patiria miniata] -LDEEMEQEEDWDRSTVLDPMWEIQQTKTFTAWCNSHLRKSGTQIEHIDKDFCNGLKLINLLEVISGERLPKPEKGKMRVHKISNVQKALDYIMSKGVRLVSIGAEEIVDCNLKMTLGMIWTIILRFAIQDISVEESTAKEGLLLWCQRKTAPYNNVRVQNFHTSWKDGLAFCALIHRHRPDLLDYNSLSKDDPKKNLELAFEVAEKYLDIPKMLDPEDIINTAKPDERSIMTYVSCYYHAFAGAQQAENAANRLCKVLRMNQDNERLMDEYDRLASDLKRKRPWLEDRLSENSLPAVQDKLDEFRNYRGKEKPPKTEEKGQLETNYNTLQTKLRLSNRPAYIPQEGKMVSDIAKAWKGLEQSERGFEDWLLAEMRRLERLDHLARKFRHKCEIHEGWAEGKEPDLENNDYSGIKLNEIYALKKKHEAFESDLAAHQDRVEQIAAIAQEMNLLEYHDIGPINSRCQTICDQWDRLGNLTSARRQTLETIQDLLQRVDSLFLDFAKKAAPFNNWMEGASEDLVDVFSVHTVDEIRGLIQPHEEFKATLNDAQSAFDELVEIGNKIKNLFAEHNLDIDKSNPYTTLTVQDIVSKWQEVLKLVPERDQALQSELLKQESNERLRYQFAKKANVVGPWIEGQTMKVNNLHME-RGALEEHLASLQRIERDVVDYKAHMDELEMYNQSVQEAMIFENEHTKYTMETIRVGYEQLVTTTRRLINELENQILTRDSKGITEEQFEIFRQSFNIFDKNHSGKLDPMEFKSCLVSLSMAPPNPEFDRIMQSVDPNHDGHVTFEAFLDYMSREATDTDTSEQVKGSFKVLAGNKNYITKEDLMRELPPDQAEYCIARMAPYQGPDAIPGALDYLSFSTALYGESDL >XP_031561014.1 alpha-actinin-1-like [Actinia tenebrosa] EQEYYFYGEED---KGLLDPAWEKQQKKTFTAWCNSHLRKSGKAIETMEEDFRDGVLLLLLLESLSGDKL-TAERGKLRFHRIANVNKALDFVASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDIAIEDSFAKDGLLLWCQRKTAPYKNVKVTNFHTSFKDGLAFCALIHRHRPDLIEYEKLRKDDPMTNLNTAFDVAETHLDIPKMLDPEDMIDNERPDERAVMTYVSSYYHALTSSQQADTAAKRIGKVLTINRDNEKMMEDYETLASDLNKTLPRFKNRDSDGTLADMQKKLEELRNYRGGEKPPKVEDKGALETNFNTLQTKLRLSNRPAFLPTEGKMINDINDAWGNLEAAEKDFEDWLLTEMRRMERLDHLAQKFKHKCDIHEAWTDGKDVTLSRDDFSDASLPDILALMKKHEAFESDLAAHQDRVDQIVAIAQELNALEYSEIDKVNSRCQKICDNWKDLGELTMHRLQKLEETEQCLQQLDNLRLEFAKKAAPFNNWLESAREDLMDMFIVHTVEEIQELLDAHEAFKANMPAAENEYQAIIEIAEQIKQLSS-------QDNPYTSLTGEDIKTAWNEVLNLVPQRDASLREERSKQERNETLRIDFAKKANVVGPWIQQQGENLRSIGFHMTGTLEKNLGLLQELETLIANYKPNMDELEAINQQVQQALIFENTHTKYTMEALRIGWEQLLTATARNINEVENQILTRDSKGITEEQMKEFRASFNFFDKDENGKLEKHEFKQCLVSLGYNVKDKEFERLMTIVDPNNTKKVTFQAFVDFMTRETADSDTAEQVMESFRILAGDKAYITAEELQRELPPDQAEYCIARMAPYEGKDAVPGALDYMSFSTALYGESDL >XP_797562.1 alpha-actinin isoform X1 [Strongylocentrotus purpuratus] DDDEDMKQEDEWNRDEVLDPAWERQQRKTFTAWCNSHLRKANANIEEISSDFCNGLKLMMLLEVISSEKLPPPERGKMRFHKIANVNKALDFITSKGVRLVSIGAEEIVDMNLKMILGMIWTIILRFAIQDISIEDHSAKEGLLLWCQRKTAPYRNVNIQNFHNSWKDGLGFCALIHRHRPDLLDYSKLKKDDPATNLELAFSVAEKHLDIPRMLDAEDLMNTARPDDKSIMTYVSAYYHAFSGAQKAETAAGRINKVLGLNMENQRLMDEYEKLASDLRRKKPWLEDRLQESTLDAMQKKLDEFRTYRGKEKPPKTEDKARLETNFNTLQTKLQLTNRPAYRPSEGKLVSDIAKAWKGLETSEKGFEDWLLAEMRRLERLDHLAKKFRHKCDIHEAWAAGKEEILR-EDFSGMRLNDLKAKCRKHEAFESDLAAHQDRVEQIAAIAQEMNDLEYHAIGPINQRCQTICDQWDTLGSLSMGRSEALAKAVMILESIDSRQLDFAKKAAPFNNWLDGAREDLMDMFIVHTLEEISELLDAHEVFKNNLGAAEEEFNSLAALANEINKTIEMNNVGI-KENPYTTLTVQVVVEKWRDLCELVPKRDEALSNELRRQQSNEQMRVRFAQLANQVGPWIEKQMAATMNIAIGLNVPLESQLHKLQDYEHTVLQYKSNVDDLESCNKSVQEAMIFENPHTQYTMETIRVGWEQLLTAIRRYINEIENNILTRDTKGITEEQLNEFRASFNHFDKNRTQRLEPLEFRSCLVSLGYDLRDIEFQRIMALVDPSGTGKVSFQSFLDFMTREMSDADTVEQVVDSFKVLANGKAYILPDELRMELPPEQAEYCIARMAPFNGTGAAPGALDYMSFSSALYGQSEL >NP_506128.1 AcTiniN [Caenorhabditis elegans] -QPGYTQQEEEWDREGLLDPAWEKQQKKTFTAWCNSHLRKAGTSIDTIEEDFRNGLKLMLLLEVISGEPLPKPDRGKMRFHKIANVNKALEYIESKGVKLVSIGAEEIVDGNVKMTLGLIWTIILRFAIQDINVEELSARDGLLLWCQRKTAPYNNVNVQNFHNSWKDGLAFCALIHRHRPDLLDYSQLHKGDPIHNLNLAFDIAEKHLDIPKMLDAEDMAN-SQPDEKAVMTYVSCYYHYFSGMRKAETAANRICRVLKVNQENEKMMEDYENLASDLNRWMPWLANRSTDDTLQQAQQKLEDYRNYRRREKPPRIEDKGRLETLFNTLQTRLRLSNRPAFLPRDGHLIKDINAAWAGLEDSEKGFEEWLLSEIMRLERLEHLAEKFRRKCALHEEWAHGKEDALRSNDWRSCGLYKIKALRKRHEAFESDLGAHQDRVEQIAAIARELNNLRYPDIGPINARCQAICSQWDRLGQLSSKRRETLEDAERIAERLDSLYLDFAKRAAPFNNWLDGAREDLADLVIVHEMREIEELVNAHDQFKSTLGDADREFSSINQIEHEVEHLVTSHGLDRELRNPYTDLSASDIRRKWGEVQNSVPRRDSQLQAELKRQQNNERLRTIFAEKANQVGPWLERELEQVLAIGLGGRGRLEDAIQQLRSIQRNVLGYKPNLDELERVHQEMQENFVFENRKSRYSMESLRVGWETLLTSINKTINEFENQVLLRDSKGISEEQIAEFRASFSHFDKERAG-LDPEQLRSCLISVGYTIRDAELHRVLAHVDPNRMGRVPFEAFLDFMTKENSDQDTVEQMIDSFRILASGKTFITADELERELPRDQAAYCMARMAPSREPGAPPRSFDYVTFSRSLYSQ--- >XP_005212033.1 alpha-actinin-1 isoform X4 [Bos taurus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_002719567.1 PREDICTED: alpha-actinin-1 isoform X1 [Oryctolagus cuniculus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRLPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNSRCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_024087665.1 alpha-actinin-1 isoform X4 [Pongo abelii] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >NP_001229990.1 alpha-actinin-1 [Sus scrofa] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDR-----------------------EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_031409431.1 alpha-actinin-1 isoform X1 [Meleagris gallopavo] ----------------------------------------------------------MLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRMGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL >XP_003824135.1 alpha-actinin-1 isoform X1 [Pan paniscus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >XP_019688751.1 alpha-actinin-1 isoform X1 [Felis catus] AREPGLSPHRRHASLIWLQPPVEKAPTETFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINSKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFAAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_027827748.1 alpha-actinin-1 isoform X1 [Ovis aries] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWEHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_004055393.1 alpha-actinin-1 isoform X1 [Gorilla gorilla gorilla] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKETMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL >XP_005502325.2 alpha-actinin-1 isoform X3 [Columba livia] LKASEGEQGDQAEQ--------DTAEERTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPHEINGKWEHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDCEDFRACLISMGYTM-EAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYNGRDAVPGALDYMSFSTALYGESDL >XP_017909535.1 PREDICTED: alpha-actinin-1 isoform X3 [Capra hircus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_006025253.1 alpha-actinin-1 isoform X1 [Alligator sinensis] SQQTNMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVPGALDYMSFSTALYGESDL >XP_006266503.1 PREDICTED: alpha-actinin-1 isoform X1 [Alligator mississippiensis] SQQTNMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLRRTIPWLENRAPENTMQAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWAGLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHESWTDGKEAMLQQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERQAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQQIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYHGPDAVPGALDYMSFSTALYGESDL >XP_020745442.1 alpha-actinin-1 [Odocoileus virginianus texanus] SQQTNMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDVGKALPPCPERSPQNPSIPPNPSLGTVPDWALPLVPAADRGRLGLSQDFGELSSRLFLSPLYSCFPLRSK--EDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHTRQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLNHLRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITVDELRRELPPDQAEYCIARMAPYTGPDAVPGALDYMSFSTALYGESDL >XP_040189308.1 alpha-actinin-1 isoform X1 [Rana temporaria] GQHTNMQPEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALNFITGKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPYTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRILKVLAVNQENEQLMEDYEKLASDLRRTIPWLEDRAPENTMQAMQQKLEDFRDYRRQHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGKMVSDINNAWGGLEQGEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKENMLQKKDYETASLSDIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGVLTQKRREALEKTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLGTAHEQFKATLPEADKERQAILGIHNEVSKIAQTYHVNMAGTNPYSTILPIEINNKWDHVRQLVPRRDQALMEEHARQQQNERLRKQFGAQANVIGPWIQTKMQEIGKISIEMNGTLEDQLSHLRQYEKNIVNYKPKIDQLESDHQQIQEALIFDNKHTNYTMEHTRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRNSFNHFDRDHNGTLGPEEFKACLISLGYDIGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVVSSFKVLAGDKNYITADELRRELPPDQAEYCIARMAPYIGHDAVPGALDYMSFSTALYGESDL
PhyML tree of selected proteins ((((tr_B8JHU4_B8JHU4_DANRE_Actinin__alpha_1_OS_Danio_rerio_OX_7955_GN_actn1_PE_1_SV_1:0.01621069,(XP_030299611_1_alpha_actinin_1_isoform_X3__Sparus_aurata_:0.00523762,(XP_023807396_1_alpha_actinin_1_isoform_X5__Oryzias_latipes_:0.02401141,XP_015824660_1_PREDICTED__alpha_actinin_1_isoform_X3__Nothobranchius_furzeri_:0.01347733):0.00272495):0.01405412):0.0284834,(XP_039253681_1_alpha_actinin_1_like_isoform_X1__Styela_clava_:0.26320458,((NP_506128_1_AcTiniN__Caenorhabditis_elegans_:0.43790212,(XP_026299388_1_alpha_actinin__sarcomeric_isoform_X2__Apis_mellifera_:0.04301797,NP_477484_2_alpha_actinin__isoform_A__Drosophila_melanogaster_:0.04672482):0.13398045):0.05872094,(XP_031561014_1_alpha_actinin_1_like__Actinia_tenebrosa_:0.41297572,(XP_797562_1_alpha_actinin_isoform_X1__Strongylocentrotus_purpuratus_:0.30895433,XP_038075921_1_alpha_actinin_4_like_isoform_X1__Patiria_miniata_:0.32396753):0.09677757):0.03017539):0.0911787):0.19203856):0.01164436,((XP_043328307_1_alpha_actinin_1_isoform_X2__Cervus_canadensis_:0,(((NP_001229990_1_alpha_actinin_1__Sus_scrofa_:0.00000001,(XP_002719567_1_PREDICTED__alpha_actinin_1_isoform_X1__Oryctolagus_cuniculus_:0.00218626,((XP_038968920_1_alpha_actinin_1_isoform_X1__Rattus_norvegicus_:0.0030392,NP_598917_1_alpha_actinin_1_isoform_1__Mus_musculus_:0.00407279):0.00321575,((XP_024087665_1_alpha_actinin_1_isoform_X4__Pongo_abelii_:0.00000001,(XP_016781746_1_alpha_actinin_1_isoform_X1__Pan_troglodytes_:0.00000001,(sp_P12814_ACTN1_HUMAN_Alpha_actinin_1_OS_Homo_sapiens_OX_9606_GN_ACTN1_PE_1_SV_2:0.00000001,XP_003824135_1_alpha_actinin_1_isoform_X1__Pan_paniscus_:0.00000001):0.00000001):0.00000001):0.00000001,XP_004055393_1_alpha_actinin_1_isoform_X1__Gorilla_gorilla_gorilla_:0.00113731):0.00159097):0.00244824):0.00065585):0,(XP_853103_1_alpha_actinin_1_isoform_X5__Canis_lupus_familiaris_:0.00111005,XP_019688751_1_alpha_actinin_1_isoform_X1__Felis_catus_:0.02903157):0.00116581):0.00113936,((XP_027827748_1_alpha_actinin_1_isoform_X1__Ovis_aries_:0.00113921,XP_020745442_1_alpha_actinin_1__Odocoileus_virginianus_texanus_:0.07492486):0.00000001,((XP_005212033_1_alpha_actinin_1_isoform_X4__Bos_taurus_:0.00000001,XP_017909535_1_PREDICTED__alpha_actinin_1_isoform_X3__Capra_hircus_:0.00000001):0.00000001,KAF4017596_1_hypothetical_protein_G4228_009207__Cervus_hanglu_yarkandensis_:0.00000001):0.00000001):0.00000001):0):0.01039636,((XP_006025253_1_alpha_actinin_1_isoform_X1__Alligator_sinensis_:0.00000001,XP_006266503_1_PREDICTED__alpha_actinin_1_isoform_X1__Alligator_mississippiensis_:0.00000001):0.00193593,(XP_005502325_2_alpha_actinin_1_isoform_X3__Columba_livia_:0.03955766,(XP_031409431_1_alpha_actinin_1_isoform_X1__Meleagris_gallopavo_:0.00000001,XP_015142743_1_alpha_actinin_1_isoform_X2__Gallus_gallus_:0.00000001):0.00257235):0.00360544):0.00210281):0.00751149):0.01067852,OCT68674_1_hypothetical_protein_XELAEV_18039961mg__Xenopus_laevis_:0.02889396,XP_040189308_1_alpha_actinin_1_isoform_X1__Rana_temporaria_:0.03601156);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)