PB0049

DATABASE

Click here to access PB0049 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0049	P06727	Apolipoprotein A-IV	APOA4	apolipoprotein A4	Homo_sapiens	May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Domains

Gene Ontology

PF01442 (2_Apolipoprotein)

GO:0009986 (colocalizes with) cell surface GO:0005319 (enables) lipid transporter activity GO:0005507 (enables) copper ion binding GO:0005515 (enables) protein binding GO:0005543 (enables) phospholipid binding GO:0008289 (enables) lipid binding GO:0015485 (enables) cholesterol binding GO:0016209 (enables) antioxidant activity GO:0031210 (enables) phosphatidylcholine binding GO:0042802 (enables) identical protein binding GO:0042803 (enables) protein homodimerization activity GO:0060228 (enables) phosphatidylcholine-sterol O-acyltransferase activator activity GO:0120020 (enables) cholesterol transfer activity GO:0002227 (involved in) innate immune response in mucosa GO:0006695 (involved in) cholesterol biosynthetic process GO:0006869 (involved in) lipid transport GO:0006982 (involved in) response to lipid hydroperoxide GO:0007159 (involved in) leukocyte cell-cell adhesion GO:0008203 (involved in) cholesterol metabolic process GO:0010873 (involved in) positive regulation of cholesterol esterification GO:0010898 (involved in) positive regulation of triglyceride catabolic process GO:0014012 (involved in) peripheral nervous system axon regeneration GO:0016042 (involved in) lipid catabolic process GO:0019430 (involved in) removal of superoxide radicals GO:0030300 (involved in) regulation of intestinal cholesterol absorption GO:0032374 (involved in) regulation of cholesterol transport GO:0033344 (involved in) cholesterol efflux GO:0033700 (involved in) phospholipid efflux GO:0034014 (involved in) response to triglyceride GO:0034371 (involved in) chylomicron remodeling GO:0034372 (involved in) very-low-density lipoprotein particle remodeling GO:0034375 (involved in) high-density lipoprotein particle remodeling GO:0034378 (involved in) chylomicron assembly GO:0034380 (involved in) high-density lipoprotein particle assembly GO:0034445 (involved in) negative regulation of plasma lipoprotein oxidation GO:0035634 (involved in) response to stilbenoid GO:0042157 (involved in) lipoprotein metabolic process GO:0042632 (involved in) cholesterol homeostasis GO:0042744 (involved in) hydrogen peroxide catabolic process GO:0043691 (involved in) reverse cholesterol transport GO:0045723 (involved in) positive regulation of fatty acid biosynthetic process GO:0046470 (involved in) phosphatidylcholine metabolic process GO:0046889 (involved in) positive regulation of lipid biosynthetic process GO:0051006 (involved in) positive regulation of lipoprotein lipase activity GO:0055088 (involved in) lipid homeostasis GO:0065005 (involved in) protein-lipid complex assembly GO:0070328 (involved in) triglyceride homeostasis GO:0120009 (involved in) intermembrane lipid transfer GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005769 (located in) early endosome GO:0005788 (located in) endoplasmic reticulum lumen GO:0005829 (located in) cytosol GO:0045202 (located in) synapse GO:0062023 (located in) collagen-containing extracellular matrix GO:0070062 (located in) extracellular exosome GO:0072562 (located in) blood microparticle GO:0034361 (part of) very-low-density lipoprotein particle GO:0034364 (part of) high-density lipoprotein particle GO:0042627 (part of) chylomicron

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P06727|APOA4_HUMAN Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4 MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES >tr|B3DHC5|B3DHC5_DANRE Apolipoprotein A-IV b, tandem duplicate 2 OS=Danio rerio OX=7955 GN=apoa4b.2 PE=1 SV=1 MKVLVVFALAVFTGCQANLFYADEPKPQLEQLTDAFWSYVSKATQTAEETVKMIRESQLG QEVNERLTQSADMASEYAVVLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEP YADNMKSQIQQRVEELRAAMAPYADSLDSETLKATLLQKSEELRGNLEQSVKELQVQLEP YTAELKEKVDQHLQEFQKTVTPLTEDLQVQIRERAQMVQQSLTPYAEDLKEKLDPYAQNL KDQLASLYESYTKRN >tr|Q3B7G4|Q3B7G4_DANRE Apolipoprotein A-IV OS=Danio rerio OX=7955 GN=apoa4b.1 PE=2 SV=1 MKLYLILAFVAFTGCQANLFYADEPKPQLEQLTDAFWSYVSKATQTAEETVKMIRESQLG QEVNERLTQSADMASEYAVTLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEP YADNMKSQIQQRVEELRAAMAPYADSLDSETLKATLLQKSEELRGNLEQSVKELQAQLEP YTAELKEKVDQHLQEFQETVSPLAEDLQVQIRERAQIVQQSLTPYAEDLKEKLDPYAQNL KDQLISLYDSFTKRY
Selected proteins from model organisms >sp|P06727|APOA4_HUMAN Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4 MFLKAVVLTLALVAVAGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNA LFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEV SQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLR PHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEG LTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQV EEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKE KESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES >tr|B3DHC5|B3DHC5_DANRE Apolipoprotein A-IV b, tandem duplicate 2 OS=Danio rerio OX=7955 GN=apoa4b.2 PE=1 SV=1 MKVLVVFALAVFTGCQANLFYADEPKPQLEQLTDAFWSYVSKATQTAEETVKMIRESQLG QEVNERLTQSADMASEYAVVLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEP YADNMKSQIQQRVEELRAAMAPYADSLDSETLKATLLQKSEELRGNLEQSVKELQVQLEP YTAELKEKVDQHLQEFQKTVTPLTEDLQVQIRERAQMVQQSLTPYAEDLKEKLDPYAQNL KDQLASLYESYTKRN >tr|Q3B7G4|Q3B7G4_DANRE Apolipoprotein A-IV OS=Danio rerio OX=7955 GN=apoa4b.1 PE=2 SV=1 MKLYLILAFVAFTGCQANLFYADEPKPQLEQLTDAFWSYVSKATQTAEETVKMIRESQLG QEVNERLTQSADMASEYAVTLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEP YADNMKSQIQQRVEELRAAMAPYADSLDSETLKATLLQKSEELRGNLEQSVKELQAQLEP YTAELKEKVDQHLQEFQETVSPLAEDLQVQIRERAQIVQQSLTPYAEDLKEKLDPYAQNL KDQLISLYDSFTKRY >KAB0370821.1 hypothetical protein FD755_017230 [Muntiacus reevesi] MFLKAVVLSLALVAVTGAQAEVNADQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKL VPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTVY AQRMETVMRQNRDQLQASLAPYAEELQATVDQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQLEG LAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPDNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQ QLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEETPAPLGG >KAB0347353.1 hypothetical protein FD754_012210 [Muntiacus muntjak] MFLKAVVLSLALVAVTGAQAEVNADQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKL VPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLQRQLTVY AQRMETVMRQNRDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQLEG LAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPDNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQ QLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEETPAPLGG >XP_043338500.1 apolipoprotein A-IV [Cervus canadensis] MPGAAHSHFLHSFSTDLQWMGYHCAHFTGRIWCSKRLSQPSEEPGMFLKAVVLSLALVAVTGAQAEVNADQVATVIWDYF SQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLP HASEVSQKIGDNVRELQQRLGPYAEELRAQVDTQAQQLRRQLTVYAQRMETVMRQNRDQLQASLAPYAEELQATVNQRVE ELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVH GSQLGNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFF NTLKEKESQAPALPAQEEAPAPLGG >OWK18067.1 APOA4 [Cervus elaphus hippelaphus] MFLKAVVLSLALVAVTGAQAEVNADQVATVIWDYFSQLGNNAKKALTVYAQRMETVMRQNRDQLQASLAPYAEELQATVN QRVEELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVV SSVHGSQLGNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKV SSFFNTLKEKESQAPALPAQEEAPAPLGG >NP_001083577.1 uncharacterized protein LOC399000 precursor [Xenopus laevis] MLLKVAALALVLCAITGSQADVRTDKVVGAFWDYVSQLHSSTKDTVEQIQQSDISKQLNVLIQDNMKSVNLYAGELQSQL IPFAKQIHDQMTQDSEKLREQIQQELEKLRVKISPYADEVHKQVSKNLEELQLKLTPYAEELKSQLEKNTNTISQQLRSV VEEMDAKIRENAGNLQESLAPYSVKLQNQIDESVDQLRKQLNPYTDEVRDKIGHQVQKLRESLSPYAEEMQESLAKQIES MEFQMRKSVEQVDTQIKEFTEQLKNQLSPYADELKVKLQENAMDAKQTLEPYLTEISQQMDQKIAEFKVSITPYGEALNK GLVQRVEDMKQKFGKYTVTVQDQMEYLEKDIREKFSDFINKGITTEN >XP_040181291.1 apolipoprotein A-IV-like [Rana temporaria] MWVKVAALALLVCAVTGSQAEVSTDQVSDAFWKYFTQLTTGTKDTVDQIQQSDISKQLNTLIEENLKSVNVYAGELQKQL IPFAKQIQEKLTQDPEKVREQITTELERLKVKISPYADELHKHLSNNVKELQIKLAPYAEEFQTKLDKNAQEFSQQLKSV TNDLEAKFKENADHIQAALATYSQEFQVKVDENMDQLRKQVTPITGKVKENIDQQIQELYKSLNPYAEDVQDELKKQIQN MEFQMRKNVDELENRALELTVQLREQLYPYANELRNKVNGDMANVKQMLEPYLTQVNQQIDQKITEFKGTITPEVEALNK ALVQRVEDMKKKLGEYTVTMQDQVEYIQKDVRDKIHEFINQGVSNEN >XP_021140876.1 apolipoprotein A-I [Columba livia] MRAVVVALALLCLTGTQARSFWQHDEPQAPLDRLRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLSAAV AKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVKEKIRPFLDQFSAKWTEELEQYRQRLVPLAQELKDITKQKVELV QERLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIRDKGIPQAAEYQAKVVEHLGNLREKLTPLAQDFKER LAPYAESLKTRIIALLDDFQKRVA >XP_004078299.1 apolipoprotein A-I isoform X2 [Oryzias latipes] MKVLAVLVLAVFTGCNANLFYADAPRPQLEVVADAFWDYVSKATQTADETLDMIKKTQFGQDVSARLTESATLANEYATS LHEQLPPEAQQLITKVTTEAEVLRERVNQELNTAKEKLEPYAETLKSHIQERVEQLKQELAPYADSLDSETLRATLVQKS EELKANLEQSVKDLQTQLGPYTDDLKQKVDQHLQDFKERVAPISVRVQSEIGQRAQQVKEMASPYVDRLRERLDPYAQDL QARLTSLYDSFVKSS >XP_030268700.1 uncharacterized protein LOC115579335 [Sparus aurata] MKVLVVLALAVFTAGCNANIVWQNQPKQQVDMVKDAFWDYVAKATTTAEDSLKQIRQSQLGKEVNTLISESTEAVNKLTD ALRTQVAPLTQDLVSKFTQEAEQLKTRVEKDLTAMGARLQPYTEELVADLQRKVEELKRDAVPYANAMDSESLKTVLLQR SQELKVQMDENVNRLQAQMVPYSEEIKEKMEQSVEEFRRSMIPLAQSFESQLTQKTQEIQQSLIPLGEELKAKLDADTQN MKRQLTGLWRSFTKLIQYCINSGRGAQSASQTSQIRITQVSVLLLIMKVFAVIFVLAALSGCHARSLLSPDKTPWEATVD KFNDYFTDLNTRADEVVSGIKSSQISRELDTLIQDSMSELSMYKDDVQTKLAPYAQEAGERLAADLQKLANKLRDHMMEG REQMDKYSQELQTMMEQNADDVRTRVSAYTRKLKKRLNKDTQEIKRQVADYLDEFQSRTSDNMEEMKTRLDPYFAQVRDN AQAKMSTLNDLLRSQVENMKEKIQTTAEDIKERIETTAGDMKSTMAEKMEELNEWFKPFVSMFTA >XP_015829671.1 PREDICTED: apolipoprotein A-IV-like [Nothobranchius furzeri] MKVLVVLALFSVCRANILWADPPKPNMEVVREAFWDYVARATQTAEDSLKQIQASELGQEVNTRIAQNTDWVNQYIASLQ TQVAPLTQDFMTRFTQEAERLKARLENDLTGVGDNVKPYAEQMVLKLQNQVEELKKEIAPYAESVDPEALSAALLQKSQA LKGQLETSATQLQAQVVPYTEDMRQKMEQSLEDFQSSVLPLAQSFESQLTQKSQEIQQKLVPYGEELKAKLDSSAQDLQA QLTALWESFTQKTQ >NP_031494.2 apolipoprotein A-IV precursor [Mus musculus] MFLKAAVLTLALVAITGTRAEVTSDQVANVVWDYFTQLSNNAKEAVEQFQKTDVTQQLSTLFQDKLGDAS TYADGVHNKLVPFVVQLSGHLAQETERVKEEIKKELEDLRDRMMPHANKVTQTFGENMQKLQEHLKPYAV DLQDQINTQTQEMKLQLTPYIQRMQTTIKENVDNLHTSMMPLATNLKDKFNRNMEELKGHLTPRANELKA TIDQNLEDLRRSLAPLTVGVQEKLNHQMEGLAFQMKKNAEELQTKVSAKIDQLQKNLAPLVEDVQSKVKG NTEGLQKSLEDLNRQLEQQVEEFRRTVEPMGEMFNKALVQQLEQFRQQLGPNSGEVESHLSFLEKSLREK VNSFMSTLEKKGSPDQPQALPLPEQAQEQAQEQAQEQVQPKPLES >NP_036869.2 apolipoprotein A-IV precursor [Rattus norvegicus] MFLKAVVLTVALVAITGTQAEVTSDQVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQLNTLFQDKLGNIN TYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYAT DLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKA TIDQNLEDLRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELQTKVSTNIDQLQKNLAPLVEDVQSKLKG NTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDVESHLSFLEKNLREK VSSFMSTLQKKGSPDQPLALPLPEQVQEQVQEQVQPKPLES >NP_990269.1 apolipoprotein A-IV precursor [Gallus gallus] MSPKAALLLVLLAVAGTRADVSPDQVATVLWRYFTELGSSAKETVDQLQQAEITKQLNTLLQSNLQSANS YAEELQRRLVPFATELQAQLVQDSQRLKKQIQQELAELQAKLAPYADEVHQQIGTNIRELQAKLSPYADE LRSQVDRGTGELRRALEPFATELREKLQDNADSIQASLGPYAERLQQQIDSSVEGLKGQLTPLADELKEQ VAQSVEGLRKGLSPYAQEVQDGLNRQLQSLTAQMERAAEELRSRLAASSEEMRAQLSPLAQELQEALRGD AEAMQQRLAPLAQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLESGTAGVEDHLDLLEKEV REKVATFLSTTEQAES >NP_999553.1 apolipoprotein A-IV precursor [Sus scrofa] MFLKAVVLSLALVAVTGARAEVNADQVATVMWDYFSQLGSNAKKAVEHLQKSELTQQLNTLFQDKLGEVN TYTEDLQKKLVPFATELHERLTKDSEKLKEEIRRELEELRARLLPHATEVSQKIGDNVRELQQRLGPFTG GLRTQVNTQVQQLQRQLKPYAERMESVLRQNIRNLEASVAPYADEFKAKIDQNVEELKGSLTPYAEELKA KIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKQAEELKAKISANADELRQKLVPVAENVHGHLKG NTEGLQKSLLELRSHLDQQVEEFRLKVEPYGETFNKALVQQVEDLRQKLGPLAGDVEGHLSFLEKDLRDK VNTFFSTLKEEASQGQSQALPAQEKAQAPLEG >XP_522192.2 apolipoprotein A-IV [Pan troglodytes] MFLKAVVLTLALVAVTGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVN TYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVLELQQRLEPYAD QLRTQVNTQAEQLRRQLTPYAERMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKV KIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRG NTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES >XP_546510.3 apolipoprotein A-IV [Canis lupus familiaris] MFLKAVVLTLSLVAITGARAEVSADQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLNALFQDKMGQVN TYTDNLQKKLVPFATELHERLSKDSEKLKEEIRKELEELRARLLPHASEVSQKIGDNMRELQQRFGPYAE ELRTQVNTHAEQLRNQLTSHAQRMQSALRQNVDDLHSSLTPFADELKAKIDQNVEELKGHLTPYTDELKV KIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKISANAEELRQRLAPVAEDVRGKLKD NTAGLHKSLAELSSRLDQQVEEFRRNVGPYGETFNKALLQQVEELRQKLGPYAGDMEDHLSFLEKDLRDK VNSFFSTLQEKESQDTPVALPKQEQEQSAVPLES >XP_005215909.1 apolipoprotein A-IV isoform X1 [Bos taurus] MYHCAHFTGRIWCSKRLSQPSEEPRMFLKAVVLSLALVAVTGAEAEVNADQVATVIWDYFSQLGNNAKKA VEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEDLRARLLP HATEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTPYAERMEKVMRQNLDQLQASLAPYAEE LQATVNQRVEELKGRLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAK ISAKAEELRQGLVPLVNSVHGSQLGNAEDLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDTL RQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEMPVPLGG >NP_001164881.1 apolipoprotein A-IV precursor [Oryctolagus cuniculus] MFLKAVVLTLALVAFTGAQAEVSADQVATVMWDYFSQLSNNAKEAVEQLQKSELSQKLNNLFQDKLGEVN TYADDMQKKLMPFIVDLQERFTKDSEKLKEEIRKELEDLRAQLLPRAQEVSQKIGDNMQSLQELLAPYTT ELRTQVNAQAEQLQHQLAGYTQRMQTTFHENMGNLQASLTPYTDELKSKIDQKVGELKGHLTSFADNLKT KIDQNKEGLRISLAPYTQDMQEKLNHQLEGLAFQMKKNVDELKAQFYANAEELRGQLVLAAEDVRSKLSG NGEGLQKSLAELSGRLSRQVEEFRRKVEPYGETYNKALVQQVEQFRQMLGPYAGNVEGHLSFLEKDLRDK VSSFFSTMKQKEIQDTPPADALPGQGQEQVQALPLAPLES >XP_009245367.1 apolipoprotein A-IV [Pongo abelii] MFLKAVVLALALVAVTGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVN TYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEEVRARLLPHANEVSQKIGDNVRELQQRLEPYAD QLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLHASLRPHADELKAKIDQNVEELKGRLTPYADEFKV KIDQTVEELRRSLAPYAQDAQEKLNHQLEGLAFQMKKNAEELKTRISASAEELRQRLAPLVEDVRGNLRG NTEGLQKSLAELGGHLDRQVEEFRSRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQQQEQQQEQQQEQQQEQQQGQVQMLAPLES >XP_003212771.2 apolipoprotein A-IV [Meleagris gallopavo] MSPKAAAFLLVLLAVAGTRADVSPDQVATVLWKYFTELGSNAKETVDQLQQAEITKQLNTLLQSNLQSMN SYAEELQRRLVPFATELQAQLVQDSQRLKEQIQRELAELQAKLAPYADEVHQQIGTNIRELQAKLSPYAD ELRSQVDRGTGELRRALEPFATELRERLQDNAGSIQASLGSYTERLQQQIDSSVEGLKEQLTPLADELKE QVAQSVEGLRKGLSPYAQEVQDGLNRQLESLTMQMERAAEELRSRLAASSEEMRAQLSPLAQELQQALSA DAEAVRQRLAPLAQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLDSGTAGVEDHLDLLEKE VREKVATFLSTTEQAES >XP_003820134.2 apolipoprotein A-IV [Pan paniscus] MFLKAVVLTLALVAVTGARAEVSADQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVN TYAGDLQKKLVPFATELHELLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLEPYAD QLRTQVNTQAEQLRRQLTPYAERMERVLRENAHSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKV KIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRG NTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDK VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQVQMLAPLES >XP_011284667.1 apolipoprotein A-IV [Felis catus] MFLRAVVLTLALVAVTGARAEVSPDQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLNALFQDKLGQVN TYADNLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAD ELRTQVNTHAEHLRRHLTSHAQRMEAVLRENVDNLQSSLTPYADEFKAKIDQNIEELKGHLTPYADELKV KIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKITANADELRQRLAPVAEDVRSKLRD NAKGLQESLAQLNSHLDRQVEEFRRNLGPYGDTFNRALVQQVEELRQKLGPYAGGMEDHLSFLEKDLRDK VNSFFITLKEKENQDRPLALPEQEQAPGPLES >XP_004016096.1 apolipoprotein A-IV [Ovis aries] MFLKAVVLSLALVAVTGAEAEVNADQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVS TYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHATEVSQKIGDNVRELQQRLGPYAE ELRSQVDTQAQQLRRQLTPYAQRMETVMRQNLDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQT KIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQGLVPVVNSVRGSQPG NAEGLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDK VSSFFNTLKEKESQAPALPAQEEIPVPLGG >XP_004052227.1 apolipoprotein A-IV [Gorilla gorilla gorilla] MFLKAVVLTLALVAVTGARAEVSADQVAMVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVN TYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLEPYAD QLRTQVNTQAEQLRRQLIPYTERMERVLRENADSLRASLRPHADELKAKIDQNVEELKGRLTPYADEFKV KIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRG NTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPYAGDVEGHLSFLEKDLRDK VNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQPQEQVQMLAPLES >XP_005689539.3 PREDICTED: apolipoprotein A-IV [Capra hircus] MFLKAVVLSLALVAVTGAEAEVNADQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVS TYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHATEVSQKIGDNVRELQQRLGPYAE ELRTQVDTQAQQLRRQLTPYAERMETVMRQNLDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQT KIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQGLVPVVNSVRGSQPG NAEGLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDK VSSFFNTLKEKESQAPALPAQEEMPVPLGG >XP_014378547.1 apolipoprotein A-IV isoform X1 [Alligator sinensis] METDRRARLLYAGLLPSPTTRTLQLLRMSLKTLALVLALLAVAGGHAELDTELDTQQVANMVWSYLTNMR SSAQDTMDQFQESKLSKQINTLLQDKFENVQTYMADLQQKLSPFAAELQARMSQDSEKLKAQIRQELEEL RAKLSPYADDVHQQITRNIQELQQKLAPYAEQLRGHVDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQAAL APYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQVESLSFQMKKAV EELQAQLARGTEELRGQLSPYTEELQGNSKRLRQTLEGLGERMDRIIDDFRQHVAPHGEAFNQKLVQKLE ELRQKLGSDTGSVEDHLAFLERDLRQQLSSFLSSLKQIESSPQDEQ >XP_006259584.3 PREDICTED: apolipoprotein A-IV isoform X1 [Alligator mississippiensis] METDRRAHLLHAGLLPSPTTRALQLLRMSLKTLALALALLAVAGSHAELDTELDAQQVANIVWSYFTDMR SSAQDTMDQIQESKLSKQINTLLQDKFANVQTYMADLQQKLIPFTAELQARMSQDSEKLKEQIRQELEEL RAKLSPYADDVHQQITRNIQEMQKKLAPYAEQLRGHMDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQAAL APYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQVESLSFQMKKAV EELQAQLAHGTEELRGQLSPYTEELQGNGKRLRQTLEGLGERMDRIIDDFRQHIAPHGEAFNQKLVQKLE ELRQKLGSDTSSVEDHLAFLERDLRQQLSSFLSSLKQIESSPQDEQ >XP_020758261.1 apolipoprotein A-IV [Odocoileus virginianus texanus] MFLKAVVLSLALVAVTGAQAEVNADQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVS TYTDDLQKKLVPFATELHERLTKDSEKLREEIRQELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAE ELRTQVDTQAQQLRRQLTVYAQRMETVMRQNMDQLQASVAPYAEELQATVDQRVEELKGRLTPYADQLQA KIDENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPG NAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNRAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDK VSSFFNTLKEKESQAPALPAQEDTPAPLGG
Mafft alignment of selected proteins >sp|P06727|APOA4_HUMAN Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4 -------------------------------------------------MFLKAVVLTLA LVAVA-GARAEV---------SAD----QVATVMWDYFSQLSNNAKEAVEHLQKSELTQQ LNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHA NEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQA SLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ LEGLTFQMKKNAEELKARIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ASAEELRQRLAPLAEDVRGNLRG NTEGLQKSL----AELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDV EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQE---------- ----------QVQM----LAPLES---- >tr|B3DHC5|B3DHC5_DANRE Apolipoprotein A-IV b, tandem duplicate 2 OS=Danio rerio OX=7955 GN=apoa4b.2 PE=1 SV=1 ---------------------------------------------------MK-VLVVFA LAVFT-GCQANLFYA-DEPKPQLE----QLTDAFWSYVSKATQTAEETVKMIRESQLGQE VNERLTQSADMASEYAVVLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEPYA DNMKSQIQQRVEELRAAMAPYADSLDS------ETLKATLLQKSEELRGNLEQSVKELQV QLEPYTAELKEKVDQHLQEFQKTVTPLTEDLQVQIRERAQMVQQSLTPYAEDLKEKLDPY AQNLKDQLASLYESYTKRN----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >tr|Q3B7G4|Q3B7G4_DANRE Apolipoprotein A-IV OS=Danio rerio OX=7955 GN=apoa4b.1 PE=2 SV=1 ---------------------------------------------------MK-LYLILA FVAFT-GCQANLFYA-DEPKPQLE----QLTDAFWSYVSKATQTAEETVKMIRESQLGQE VNERLTQSADMASEYAVTLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEPYA DNMKSQIQQRVEELRAAMAPYADSLDS------ETLKATLLQKSEELRGNLEQSVKELQA QLEPYTAELKEKVDQHLQEFQETVSPLAEDLQVQIRERAQIVQQSLTPYAEDLKEKLDPY AQNLKDQLISLYDSFTKRY----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >KAB0370821.1 hypothetical protein FD755_017230 [Muntiacus reevesi] -------------------------------------------------MFLKAVVLSLA LVAVT-GAQAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTVYAQRMETVMRQNRDQLQA SLAPYAEELQATVDQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQRLVPVVSSVRGSQPD NAEGLQKSL----AELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEETP------------------- -------------------APLGG---- >KAB0347353.1 hypothetical protein FD754_012210 [Muntiacus muntjak] -------------------------------------------------MFLKAVVLSLA LVAVT-GAQAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLQRQLTVYAQRMETVMRQNRDQLQA SLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQRLVPVVSSVRGSQPD NAEGLQKSL----AELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEETP------------------- -------------------APLGG---- >XP_043338500.1 apolipoprotein A-IV [Cervus canadensis] MPGAAHSHFLHSFSTDLQWMGYHCAHFTGRIWCSKRLSQPSEEP----GMFLKAVVLSLA LVAVT-GAQAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA SEVSQKIGDNVRELQQRLGPYAEELRAQVDTQAQQLRRQLTVYAQRMETVMRQNRDQLQA SLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQRLVPVVSSVHGSQLG NAEGLQKSL----AELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEEAP------------------- -------------------APLGG---- >OWK18067.1 APOA4 [Cervus elaphus hippelaphus] -------------------------------------------------MFLKAVVLSLA LVAVT-GAQAEV---------NAD----QVATVIWDYFSQLGNNAKKA------------ ------------------------------------------------------------ ---------------------------------------LTVYAQRMETVMRQNRDQLQA SLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQRLVPVVSSVHGSQLG NAEGLQKSL----AELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEEAP------------------- -------------------APLGG---- >NP_001083577.1 uncharacterized protein LOC399000 precursor [Xenopus laevis] -------------------------------------------------MLLKVAALALV LCAIT-GSQADV---------RTD----KVVGAFWDYVSQLHSSTKDTVEQIQQSDISKQ LNVLIQDNMKSVNLYAGELQSQLIPFAKQIHDQMTQDSEKLREQIQQELEKLRVKISPYA DEVHKQVSKNLEELQLKLTPYAEELKSQLEKNTNTISQQLRSVVEEMDAKIRENAGNLQE SLAPYSVKLQNQIDESVDQLRKQLNPYTDEVRDKIGHQVQKLRESLSPYAEEMQESLAKQ IESMEFQMRKSVEQVDTQIK---------------------------------------- ------------------------------------------------------------ -------------------------------------EFTEQLKNQLSPYADELKVKLQE NAMDAKQTLEPYLTEISQQMDQKIAEFKVSITPYGEALNKGLVQRVEDMKQKFGKYTVTV QDQMEYLEKDIREKFSDFINKGITTEN--------------------------------- ---------------------------- >XP_040181291.1 apolipoprotein A-IV-like [Rana temporaria] -------------------------------------------------MWVKVAALALL VCAVT-GSQAEV---------STD----QVSDAFWKYFTQLTTGTKDTVDQIQQSDISKQ LNTLIEENLKSVNVYAGELQKQLIPFAKQIQEKLTQDPEKVREQITTELERLKVKISPYA DELHKHLSNNVKELQIKLAPYAEEFQTKLDKNAQEFSQQLKSVTNDLEAKFKENADHIQA ALATYSQEFQVKVDENMDQLRKQVTPITGKVKENIDQQIQELYKSLNPYAEDVQDELKKQ IQNMEFQMRKNVDELENRAL---------------------------------------- ------------------------------------------------------------ -------------------------------------ELTVQLREQLYPYANELRNKVNG DMANVKQMLEPYLTQVNQQIDQKITEFKGTITPEVEALNKALVQRVEDMKKKLGEYTVTM QDQVEYIQKDVRDKIHEFINQGVSNEN--------------------------------- ---------------------------- >XP_021140876.1 apolipoprotein A-I [Columba livia] ---------------------------------------------------MRAVVVALA LLCLT-GTQARSFWQHDEPQAPLD----RLRDMVDVYLETVKASGKDAIAQFESSAVGKQ LDLKLADNLDTLSAAVAKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVKEKIRPFL DQFSAKWTEELEQYRQRLVPLAQELKDITKQKVELVQERLTPVAEEARDRLRGHVEELRK NLAPYSDELRQKLSQKLEEIRDKGIPQAAEYQAKVVEHLGNLREKLTPLAQDFKERLAPY AESLKTRIIALLDDFQKRVA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >XP_004078299.1 apolipoprotein A-I isoform X2 [Oryzias latipes] ---------------------------------------------------MK-VLAVLV LAVFT-GCNANLFYA-DAPRPQLE----VVADAFWDYVSKATQTADETLDMIKKTQFGQD VSARLTESATLANEYATSLHEQLPPEAQQLITKVTTEAEVLRERVNQELNTAKEKLEPYA ETLKSHIQERVEQLKQELAPYADSLDS------ETLRATLVQKSEELKANLEQSVKDLQT QLGPYTDDLKQKVDQHLQDFKERVAPISVRVQSEIGQRAQQVKEMASPYVDRLRERLDPY AQDLQARLTSLYDSFVKSS----------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >XP_030268700.1 uncharacterized protein LOC115579335 [Sparus aurata] ---------------------------------------------------MK-VLVVLA LAVFTAGCNANIVWQ-NQPKQQVD----MVKDAFWDYVAKATTTAEDSLKQIRQSQLGKE VNTLISESTEAVNKLTDALRTQVAPLTQDLVSKFTQEAEQLKTRVEKDLTAMGARLQPYT EELVADLQRKVEELKRDAVPYANAMDS------ESLKTVLLQRSQELKVQMDENVNRLQA QMVPYSEEIKEKMEQSVEEFRRSMIPLAQSFESQLTQKTQEIQQSLIPLGEELKAKLDAD TQNMKRQLTGLWRSFTKLIQYCINSGRGAQSASQTSQIRITQVSVLLLIMKVFAVIFVLA ALSGCHARSLLSPDKTPWEATVDKFNDYFTDLNTRADEVVSGIKSSQISRELDTLIQDSM SELSMYKDDVQTKLAPYAQEAGERLAADLQKLANKLRDHMMEGREQMDKYSQELQTMMEQ NADDVRTRVSAYTRKLKKRLNKDTQEIKRQVADYLDEFQSRTSDNMEEMKTRLDPYFAQV RDNAQAKMSTLNDLLRSQVENMKEKIQTTAEDIKERIETTAGDMKSTMAE---------- ----------KMEELNEWFKPFVSMFTA >XP_015829671.1 PREDICTED: apolipoprotein A-IV-like [Nothobranchius furzeri] ---------------------------------------------------MK-VLVVLA L--FS-VCRANILWA-DPPKPNME----VVREAFWDYVARATQTAEDSLKQIQASELGQE VNTRIAQNTDWVNQYIASLQTQVAPLTQDFMTRFTQEAERLKARLENDLTGVGDNVKPYA EQMVLKLQNQVEELKKEIAPYAESVDP------EALSAALLQKSQALKGQLETSATQLQA QVVPYTEDMRQKMEQSLEDFQSSVLPLAQSFESQLTQKSQEIQQKLVPYGEELKAKLDSS AQDLQAQLTALWESFTQKTQ---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------- >NP_031494.2 apolipoprotein A-IV precursor [Mus musculus] -------------------------------------------------MFLKAAVLTLA LVAIT-GTRAEV---------TSD----QVANVVWDYFTQLSNNAKEAVEQFQKTDVTQQ LSTLFQDKLGDASTYADGVHNKLVPFVVQLSGHLAQETERVKEEIKKELEDLRDRMMPHA NKVTQTFGENMQKLQEHLKPYAVDLQDQINTQTQEMKLQLTPYIQRMQTTIKENVDNLHT SMMPLATNLKDKFNRNMEELKGHLTPRANELKATIDQNLEDLRRSLAPLTVGVQEKLNHQ MEGLAFQMKKNAEELQTKVS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKIDQLQKNLAPLVEDVQSKVKG NTEGLQKSL----EDLNRQLEQQVEEFRRTVEPMGEMFNKALVQQLEQFRQQLGPNSGEV ESHLSFLEKSLREKVNSFMSTLEKKGSPDQPQALPLPEQAQEQAQEQAQE---------- ----------QVQ-----PKPLES---- >NP_036869.2 apolipoprotein A-IV precursor [Rattus norvegicus] -------------------------------------------------MFLKAVVLTVA LVAIT-GTQAEV---------TSD----QVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQ LNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHA NKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQS SMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLEDLRSRLAPLAEGVQEKLNHQ MEGLAFQMKKNAEELQTKVS---------------------------------------- ------------------------------------------------------------ -------------------------------------TNIDQLQKNLAPLVEDVQSKLKG NTEGLQKSL----EDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDV ESHLSFLEKNLREKVSSFMSTLQKKGSPDQPLALPLPEQVQEQVQE-------------- ----------QVQ-----PKPLES---- >NP_990269.1 apolipoprotein A-IV precursor [Gallus gallus] -------------------------------------------------MSPK-AALLLV LLAVA-GTRADV---------SPD----QVATVLWRYFTELGSSAKETVDQLQQAEITKQ LNTLLQSNLQSANSYAEELQRRLVPFATELQAQLVQDSQRLKKQIQQELAELQAKLAPYA DEVHQQIGTNIRELQAKLSPYADELRSQVDRGTGELRRALEPFATELREKLQDNADSIQA SLGPYAERLQQQIDSSVEGLKGQLTPLADELKEQVAQSVEGLRKGLSPYAQEVQDGLNRQ LQSLTAQMERAAEELRSRLA---------------------------------------- ------------------------------------------------------------ -------------------------------------ASSEEMRAQLSPLAQELQEALRG DAEAMQQRLAPLAQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLESGTAGV EDHLDLLEKEVREKVATFLSTTEQAES--------------------------------- ---------------------------- >NP_999553.1 apolipoprotein A-IV precursor [Sus scrofa] -------------------------------------------------MFLKAVVLSLA LVAVT-GARAEV---------NAD----QVATVMWDYFSQLGSNAKKAVEHLQKSELTQQ LNTLFQDKLGEVNTYTEDLQKKLVPFATELHERLTKDSEKLKEEIRRELEELRARLLPHA TEVSQKIGDNVRELQQRLGPFTGGLRTQVNTQVQQLQRQLKPYAERMESVLRQNIRNLEA SVAPYADEFKAKIDQNVEELKGSLTPYAEELKAKIDQNVEELRRSLAPYAQDVQEKLNHQ LEGLAFQMKKQAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ANADELRQKLVPVAENVHGHLKG NTEGLQKSL----LELRSHLDQQVEEFRLKVEPYGETFNKALVQQVEDLRQKLGPLAGDV EGHLSFLEKDLRDKVNTFFSTLKEEASQGQSQALPAQEKAQ------------------- -------------------APLEG---- >XP_522192.2 apolipoprotein A-IV [Pan troglodytes] -------------------------------------------------MFLKAVVLTLA LVAVT-GARAEV---------SAD----QVATVMWDYFSQLSNNAKEAVEHLQKSELTQQ LNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVLELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAERMERVLRENADSLQA SLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ LEGLAFQMKKNAEELKARIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ASAEELRQRLAPLAEDVRGNLRG NTEGLQKSL----AELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDV EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQE---------- ----------QVQM----LAPLES---- >XP_546510.3 apolipoprotein A-IV [Canis lupus familiaris] -------------------------------------------------MFLKAVVLTLS LVAIT-GARAEV---------SAD----QVATVVWDYFSQLSNNAKEAVEHLQQSELTQQ LNALFQDKMGQVNTYTDNLQKKLVPFATELHERLSKDSEKLKEEIRKELEELRARLLPHA SEVSQKIGDNMRELQQRFGPYAEELRTQVNTHAEQLRNQLTSHAQRMQSALRQNVDDLHS SLTPFADELKAKIDQNVEELKGHLTPYTDELKVKIDQNVEELRRSLAPYAQDVQEKLNHQ LEGLAFQMKKNAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ANAEELRQRLAPVAEDVRGKLKD NTAGLHKSL----AELSSRLDQQVEEFRRNVGPYGETFNKALLQQVEELRQKLGPYAGDM EDHLSFLEKDLRDKVNSFFSTLQEKESQDTPVALPKQEQEQS------------------ ------------------AVPLES---- >XP_005215909.1 apolipoprotein A-IV isoform X1 [Bos taurus] M--------------------YHCAHFTGRIWCSKRLSQPSEEP----RMFLKAVVLSLA LVAVT-GAEAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEDLRARLLPHA TEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTPYAERMEKVMRQNLDQLQA SLAPYAEELQATVNQRVEELKGRLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQGLVPLVNSVHGSQLG NAEDLQKSL----AELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDTLRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEEMP------------------- -------------------VPLGG---- >NP_001164881.1 apolipoprotein A-IV precursor [Oryctolagus cuniculus] -------------------------------------------------MFLKAVVLTLA LVAFT-GAQAEV---------SAD----QVATVMWDYFSQLSNNAKEAVEQLQKSELSQK LNNLFQDKLGEVNTYADDMQKKLMPFIVDLQERFTKDSEKLKEEIRKELEDLRAQLLPRA QEVSQKIGDNMQSLQELLAPYTTELRTQVNAQAEQLQHQLAGYTQRMQTTFHENMGNLQA SLTPYTDELKSKIDQKVGELKGHLTSFADNLKTKIDQNKEGLRISLAPYTQDMQEKLNHQ LEGLAFQMKKNVDELKAQFY---------------------------------------- ------------------------------------------------------------ -------------------------------------ANAEELRGQLVLAAEDVRSKLSG NGEGLQKSL----AELSGRLSRQVEEFRRKVEPYGETYNKALVQQVEQFRQMLGPYAGNV EGHLSFLEKDLRDKVSSFFSTMKQKEIQDTPPADALPGQGQEQVQALP------------ ------------------LAPLES---- >XP_009245367.1 apolipoprotein A-IV [Pongo abelii] -------------------------------------------------MFLKAVVLALA LVAVT-GARAEV---------SAD----QVATVMWDYFSQLSNNAKEAVEHLQKSELTQQ LNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEEVRARLLPHA NEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLHA SLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDAQEKLNHQ LEGLAFQMKKNAEELKTRIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ASAEELRQRLAPLVEDVRGNLRG NTEGLQKSL----AELGGHLDRQVEEFRSRVEPYGENFNKALVQQMEQLRQKLGPHAGDV EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQEQQQEQQQEQQ QEQQQEQQQGQVQM----LAPLES---- >XP_003212771.2 apolipoprotein A-IV [Meleagris gallopavo] -------------------------------------------------MSPKAAAFLLV LLAVA-GTRADV---------SPD----QVATVLWKYFTELGSNAKETVDQLQQAEITKQ LNTLLQSNLQSMNSYAEELQRRLVPFATELQAQLVQDSQRLKEQIQRELAELQAKLAPYA DEVHQQIGTNIRELQAKLSPYADELRSQVDRGTGELRRALEPFATELRERLQDNAGSIQA SLGSYTERLQQQIDSSVEGLKEQLTPLADELKEQVAQSVEGLRKGLSPYAQEVQDGLNRQ LESLTMQMERAAEELRSRLA---------------------------------------- ------------------------------------------------------------ -------------------------------------ASSEEMRAQLSPLAQELQQALSA DAEAVRQRLAPLAQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLDSGTAGV EDHLDLLEKEVREKVATFLSTTEQAES--------------------------------- ---------------------------- >XP_003820134.2 apolipoprotein A-IV [Pan paniscus] -------------------------------------------------MFLKAVVLTLA LVAVT-GARAEV---------SAD----QVATVMWDYFSQLSNNAKEAVEHLQKSELTQQ LNALFQDKLGEVNTYAGDLQKKLVPFATELHELLAKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAERMERVLRENAHSLQA SLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ LEGLAFQMKKNAEELKARIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ASAEELRQRLAPLAEDVRGNLRG NTEGLQKSL----AELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDV EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQQQE---------- ----------QVQM----LAPLES---- >XP_011284667.1 apolipoprotein A-IV [Felis catus] -------------------------------------------------MFLRAVVLTLA LVAVT-GARAEV---------SPD----QVATVVWDYFSQLSNNAKEAVEHLQQSELTQQ LNALFQDKLGQVNTYADNLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVRELQQRLGPYADELRTQVNTHAEHLRRHLTSHAQRMEAVLRENVDNLQS SLTPYADEFKAKIDQNIEELKGHLTPYADELKVKIDQNVEELRRSLAPYAQDVQEKLNHQ LEGLAFQMKKNAEELKAKIT---------------------------------------- ------------------------------------------------------------ -------------------------------------ANADELRQRLAPVAEDVRSKLRD NAKGLQESL----AQLNSHLDRQVEEFRRNLGPYGDTFNRALVQQVEELRQKLGPYAGGM EDHLSFLEKDLRDKVNSFFITLKEKENQDRPLALPEQEQAP------------------- -------------------GPLES---- >XP_004016096.1 apolipoprotein A-IV [Ovis aries] -------------------------------------------------MFLKAVVLSLA LVAVT-GAEAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA TEVSQKIGDNVRELQQRLGPYAEELRSQVDTQAQQLRRQLTPYAQRMETVMRQNLDQLQA SLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQGLVPVVNSVRGSQPG NAEGLQKSL----AELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEEIP------------------- -------------------VPLGG---- >XP_004052227.1 apolipoprotein A-IV [Gorilla gorilla gorilla] -------------------------------------------------MFLKAVVLTLA LVAVT-GARAEV---------SAD----QVAMVMWDYFSQLSNNAKEAVEHLQKSELTQQ LNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHA NEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLIPYTERMERVLRENADSLRA SLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQ LEGLAFQMKKNAEELKARIS---------------------------------------- ------------------------------------------------------------ -------------------------------------ASAEELRQRLAPLAEDVRGNLRG NTEGLQKSL----AELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPYAGDV EGHLSFLEKDLRDKVNSFFSTFKEKESQDKTLSLPELEQQQEQQQEQPQE---------- ----------QVQM----LAPLES---- >XP_005689539.3 PREDICTED: apolipoprotein A-IV [Capra hircus] -------------------------------------------------MFLKAVVLSLA LVAVT-GAEAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHA TEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTPYAERMETVMRQNLDQLQA SLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQGLVPVVNSVRGSQPG NAEGLQKSL----AELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEEMP------------------- -------------------VPLGG---- >XP_014378547.1 apolipoprotein A-IV isoform X1 [Alligator sinensis] M------------ETDRR----------ARLLYAGLLPSPTTRTLQLLRMSLKTLALVLA LLAVA-GGHAEL---------DTELDTQQVANMVWSYLTNMRSSAQDTMDQFQESKLSKQ INTLLQDKFENVQTYMADLQQKLSPFAAELQARMSQDSEKLKAQIRQELEELRAKLSPYA DDVHQQITRNIQELQQKLAPYAEQLRGHVDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQA ALAPYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQ VESLSFQMKKAVEELQAQLA---------------------------------------- ------------------------------------------------------------ -------------------------------------RGTEELRGQLSPYTEELQ----G NSKRLRQTL----EGLGERMDRIIDDFRQHVAPHGEAFNQKLVQKLEELRQKLGSDTGSV EDHLAFLERDLRQQLSSFLSSLKQIESS------PQDEQ--------------------- ---------------------------- >XP_006259584.3 PREDICTED: apolipoprotein A-IV isoform X1 [Alligator mississippiensis] M------------ETDRR----------AHLLHAGLLPSPTTRALQLLRMSLKTLALALA LLAVA-GSHAEL---------DTELDAQQVANIVWSYFTDMRSSAQDTMDQIQESKLSKQ INTLLQDKFANVQTYMADLQQKLIPFTAELQARMSQDSEKLKEQIRQELEELRAKLSPYA DDVHQQITRNIQEMQKKLAPYAEQLRGHMDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQA ALAPYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQ VESLSFQMKKAVEELQAQLA---------------------------------------- ------------------------------------------------------------ -------------------------------------HGTEELRGQLSPYTEELQ----G NGKRLRQTL----EGLGERMDRIIDDFRQHIAPHGEAFNQKLVQKLEELRQKLGSDTSSV EDHLAFLERDLRQQLSSFLSSLKQIESS------PQDEQ--------------------- ---------------------------- >XP_020758261.1 apolipoprotein A-IV [Odocoileus virginianus texanus] -------------------------------------------------MFLKAVVLSLA LVAVT-GAQAEV---------NAD----QVATVIWDYFSQLGNNAKKAVEHIQKSELTQQ LNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLREEIRQELEELRARLLPHA NEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTVYAQRMETVMRQNMDQLQA SVAPYAEELQATVDQRVEELKGRLTPYADQLQAKIDENVEELRRSLAPYAQDVQGKLNHQ LEGLAFQMKKHAEELKAKIS---------------------------------------- ------------------------------------------------------------ -------------------------------------AKAEELRQRLVPVVSSVRGSQPG NAEGLQKSL----AELSSHLEQQVEDFRRTVGPYGETFNRAMVQQLDALRQKLGPLAGDV EDHLSFLEKDLRDKVSSFFNTLKEKESQ--APALPAQEDTP------------------- -------------------APLGG----
BMGE Cleaned alignment of selected proteins >sp|P06727|APOA4_HUMAN Apolipoprotein A-IV OS=Homo sapiens OX=9606 GN=APOA4 PE=1 SV=4 MFLKAVVLTLALVAVAGARAEVQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRARLLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQTLSLPELEQQQAPLES >tr|B3DHC5|B3DHC5_DANRE Apolipoprotein A-IV b, tandem duplicate 2 OS=Danio rerio OX=7955 GN=apoa4b.2 PE=1 SV=1 --MK-VLVVFALAVFTGCQANLQLTDAFWSYVSKATQTAEETVKMIRESQLGQEVNERLTQSADMASEYAVVLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEPYADNMKSQIQQRVEELRAAMAPYADSLDS------ETLKATLLQKSEELRGNLEQSVKELQVQLEPYTAELKEKVDQHLQEFQKTVTPLTEDLQVQIRERAQMVQQSLTPYAEDLKEKLDPYAQNLKDQLASLYESYTKRN---------------------------------------------------------------------------------------------------------------------------- >tr|Q3B7G4|Q3B7G4_DANRE Apolipoprotein A-IV OS=Danio rerio OX=7955 GN=apoa4b.1 PE=2 SV=1 --MK-LYLILAFVAFTGCQANLQLTDAFWSYVSKATQTAEETVKMIRESQLGQEVNERLTQSADMASEYAVTLKKQVDPLTEELMNKITKETEVLRERLGQDLINVREKLEPYADNMKSQIQQRVEELRAAMAPYADSLDS------ETLKATLLQKSEELRGNLEQSVKELQAQLEPYTAELKEKVDQHLQEFQETVSPLAEDLQVQIRERAQIVQQSLTPYAEDLKEKLDPYAQNLKDQLISLYDSFTKRY---------------------------------------------------------------------------------------------------------------------------- >KAB0370821.1 hypothetical protein FD755_017230 [Muntiacus reevesi] MFLKAVVLSLALVAVTGAQAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTVYAQRMETVMRQNRDQLQASLAPYAEELQATVDQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPDNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEETPAPLGG >KAB0347353.1 hypothetical protein FD754_012210 [Muntiacus muntjak] MFLKAVVLSLALVAVTGAQAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLQRQLTVYAQRMETVMRQNRDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPDNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEETPAPLGG >XP_043338500.1 apolipoprotein A-IV [Cervus canadensis] MFLKAVVLSLALVAVTGAQAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHASEVSQKIGDNVRELQQRLGPYAEELRAQVDTQAQQLRRQLTVYAQRMETVMRQNRDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVHGSQLGNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEAPAPLGG >OWK18067.1 APOA4 [Cervus elaphus hippelaphus] MFLKAVVLSLALVAVTGAQAEVQVATVIWDYFSQLGNNAKKA---------------------------------------------------------------------------------------------------------------LTVYAQRMETVMRQNRDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIDENLEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVHGSQLGNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEAPAPLGG >NP_001083577.1 uncharacterized protein LOC399000 precursor [Xenopus laevis] MLLKVAALALVLCAITGSQADVKVVGAFWDYVSQLHSSTKDTVEQIQQSDISKQLNVLIQDNMKSVNLYAGELQSQLIPFAKQIHDQMTQDSEKLREQIQQELEKLRVKISPYADEVHKQVSKNLEELQLKLTPYAEELKSQLEKNTNTISQQLRSVVEEMDAKIRENAGNLQESLAPYSVKLQNQIDESVDQLRKQLNPYTDEVRDKIGHQVQKLRESLSPYAEEMQESLAKQIESMEFQMRKSVEQVDTQIKEFTEQLKNQLSPYADELKVKLQENAMDAKQTLTEISQQMDQKIAEFKVSITPYGEALNKGLVQRVEDMKQKFGKYTVTVQDQMEYLEKDIREKFSDFINKGITTEN----------------- >XP_040181291.1 apolipoprotein A-IV-like [Rana temporaria] MWVKVAALALLVCAVTGSQAEVQVSDAFWKYFTQLTTGTKDTVDQIQQSDISKQLNTLIEENLKSVNVYAGELQKQLIPFAKQIQEKLTQDPEKVREQITTELERLKVKISPYADELHKHLSNNVKELQIKLAPYAEEFQTKLDKNAQEFSQQLKSVTNDLEAKFKENADHIQAALATYSQEFQVKVDENMDQLRKQVTPITGKVKENIDQQIQELYKSLNPYAEDVQDELKKQIQNMEFQMRKNVDELENRALELTVQLREQLYPYANELRNKVNGDMANVKQMLTQVNQQIDQKITEFKGTITPEVEALNKALVQRVEDMKKKLGEYTVTMQDQVEYIQKDVRDKIHEFINQGVSNEN----------------- >XP_021140876.1 apolipoprotein A-I [Columba livia] --MRAVVVALALLCLTGTQARSRLRDMVDVYLETVKASGKDAIAQFESSAVGKQLDLKLADNLDTLSAAVAKLREDMTPYYKEVREMWLKDTESLRQELSKDLEEVKEKIRPFLDQFSAKWTEELEQYRQRLVPLAQELKDITKQKVELVQERLTPVAEEARDRLRGHVEELRKNLAPYSDELRQKLSQKLEEIRDKGIPQAAEYQAKVVEHLGNLREKLTPLAQDFKERLAPYAESLKTRIIALLDDFQKRVA--------------------------------------------------------------------------------------------------------------------------- >XP_004078299.1 apolipoprotein A-I isoform X2 [Oryzias latipes] --MK-VLAVLVLAVFTGCNANLVVADAFWDYVSKATQTADETLDMIKKTQFGQDVSARLTESATLANEYATSLHEQLPPEAQQLITKVTTEAEVLRERVNQELNTAKEKLEPYAETLKSHIQERVEQLKQELAPYADSLDS------ETLRATLVQKSEELKANLEQSVKDLQTQLGPYTDDLKQKVDQHLQDFKERVAPISVRVQSEIGQRAQQVKEMASPYVDRLRERLDPYAQDLQARLTSLYDSFVKSS---------------------------------------------------------------------------------------------------------------------------- >XP_030268700.1 uncharacterized protein LOC115579335 [Sparus aurata] --MK-VLVVLALAVFTGCNANIMVKDAFWDYVAKATTTAEDSLKQIRQSQLGKEVNTLISESTEAVNKLTDALRTQVAPLTQDLVSKFTQEAEQLKTRVEKDLTAMGARLQPYTEELVADLQRKVEELKRDAVPYANAMDS------ESLKTVLLQRSQELKVQMDENVNRLQAQMVPYSEEIKEKMEQSVEEFRRSMIPLAQSFESQLTQKTQEIQQSLIPLGEELKAKLDADTQNMKRQLTGLWRSFTKLIQDHMMEGREQMDKYSQELQTMMEQNADDVRTRVRKLKKRLNKDTQEIKRQVADYLDEFQSRTSDNMEEMKTRLDPYFAQVRDNAQAKMSTLNDLLRSQVENMKEKIQTEDIKERIETTAKPFVS >XP_015829671.1 PREDICTED: apolipoprotein A-IV-like [Nothobranchius furzeri] --MK-VLVVLAL--FSVCRANIVVREAFWDYVARATQTAEDSLKQIQASELGQEVNTRIAQNTDWVNQYIASLQTQVAPLTQDFMTRFTQEAERLKARLENDLTGVGDNVKPYAEQMVLKLQNQVEELKKEIAPYAESVDP------EALSAALLQKSQALKGQLETSATQLQAQVVPYTEDMRQKMEQSLEDFQSSVLPLAQSFESQLTQKSQEIQQKLVPYGEELKAKLDSSAQDLQAQLTALWESFTQKTQ--------------------------------------------------------------------------------------------------------------------------- >NP_031494.2 apolipoprotein A-IV precursor [Mus musculus] MFLKAAVLTLALVAITGTRAEVQVANVVWDYFTQLSNNAKEAVEQFQKTDVTQQLSTLFQDKLGDASTYADGVHNKLVPFVVQLSGHLAQETERVKEEIKKELEDLRDRMMPHANKVTQTFGENMQKLQEHLKPYAVDLQDQINTQTQEMKLQLTPYIQRMQTTIKENVDNLHTSMMPLATNLKDKFNRNMEELKGHLTPRANELKATIDQNLEDLRRSLAPLTVGVQEKLNHQMEGLAFQMKKNAEELQTKVSAKIDQLQKNLAPLVEDVQSKVKGNTEGLQKSLEDLNRQLEQQVEEFRRTVEPMGEMFNKALVQQLEQFRQQLGPNSGEVESHLSFLEKSLREKVNSFMSTLEKKGSPPQALPLPEQAQKPLES >NP_036869.2 apolipoprotein A-IV precursor [Rattus norvegicus] MFLKAVVLTVALVAITGTQAEVQVANVMWDYFTQLSNNAKEAVEQLQKTDVTQQLNTLFQDKLGNINTYADDLQNKLVPFAVQLSGHLTKETERVREEIQKELEDLRANMMPHANKVSQMFGDNVQKLQEHLRPYATDLQAQINAQTQDMKRQLTPYIQRMQTTIQDNVENLQSSMVPFANELKEKFNQNMEGLKGQLTPRANELKATIDQNLEDLRSRLAPLAEGVQEKLNHQMEGLAFQMKKNAEELQTKVSTNIDQLQKNLAPLVEDVQSKLKGNTEGLQKSLEDLNKQLDQQVEVFRRAVEPLGDKFNMALVQQMEKFRQQLGSDSGDVESHLSFLEKNLREKVSSFMSTLQKKGSPPLALPLPEQVQKPLES >NP_990269.1 apolipoprotein A-IV precursor [Gallus gallus] MSPK-AALLLVLLAVAGTRADVQVATVLWRYFTELGSSAKETVDQLQQAEITKQLNTLLQSNLQSANSYAEELQRRLVPFATELQAQLVQDSQRLKKQIQQELAELQAKLAPYADEVHQQIGTNIRELQAKLSPYADELRSQVDRGTGELRRALEPFATELREKLQDNADSIQASLGPYAERLQQQIDSSVEGLKGQLTPLADELKEQVAQSVEGLRKGLSPYAQEVQDGLNRQLQSLTAQMERAAEELRSRLAASSEEMRAQLSPLAQELQEALRGDAEAMQQRLQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLESGTAGVEDHLDLLEKEVREKVATFLSTTEQAES----------------- >NP_999553.1 apolipoprotein A-IV precursor [Sus scrofa] MFLKAVVLSLALVAVTGARAEVQVATVMWDYFSQLGSNAKKAVEHLQKSELTQQLNTLFQDKLGEVNTYTEDLQKKLVPFATELHERLTKDSEKLKEEIRRELEELRARLLPHATEVSQKIGDNVRELQQRLGPFTGGLRTQVNTQVQQLQRQLKPYAERMESVLRQNIRNLEASVAPYADEFKAKIDQNVEELKGSLTPYAEELKAKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKQAEELKAKISANADELRQKLVPVAENVHGHLKGNTEGLQKSLLELRSHLDQQVEEFRLKVEPYGETFNKALVQQVEDLRQKLGPLAGDVEGHLSFLEKDLRDKVNTFFSTLKEEASQSQALPAQEKAQAPLEG >XP_522192.2 apolipoprotein A-IV [Pan troglodytes] MFLKAVVLTLALVAVTGARAEVQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVLELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAERMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQTLSLPELEQQQAPLES >XP_546510.3 apolipoprotein A-IV [Canis lupus familiaris] MFLKAVVLTLSLVAITGARAEVQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLNALFQDKMGQVNTYTDNLQKKLVPFATELHERLSKDSEKLKEEIRKELEELRARLLPHASEVSQKIGDNMRELQQRFGPYAEELRTQVNTHAEQLRNQLTSHAQRMQSALRQNVDDLHSSLTPFADELKAKIDQNVEELKGHLTPYTDELKVKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKISANAEELRQRLAPVAEDVRGKLKDNTAGLHKSLAELSSRLDQQVEEFRRNVGPYGETFNKALLQQVEELRQKLGPYAGDMEDHLSFLEKDLRDKVNSFFSTLQEKESQPVALPKQEQEQVPLES >XP_005215909.1 apolipoprotein A-IV isoform X1 [Bos taurus] MFLKAVVLSLALVAVTGAEAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEDLRARLLPHATEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTPYAERMEKVMRQNLDQLQASLAPYAEELQATVNQRVEELKGRLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQGLVPLVNSVHGSQLGNAEDLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDTLRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEMPVPLGG >NP_001164881.1 apolipoprotein A-IV precursor [Oryctolagus cuniculus] MFLKAVVLTLALVAFTGAQAEVQVATVMWDYFSQLSNNAKEAVEQLQKSELSQKLNNLFQDKLGEVNTYADDMQKKLMPFIVDLQERFTKDSEKLKEEIRKELEDLRAQLLPRAQEVSQKIGDNMQSLQELLAPYTTELRTQVNAQAEQLQHQLAGYTQRMQTTFHENMGNLQASLTPYTDELKSKIDQKVGELKGHLTSFADNLKTKIDQNKEGLRISLAPYTQDMQEKLNHQLEGLAFQMKKNVDELKAQFYANAEELRGQLVLAAEDVRSKLSGNGEGLQKSLAELSGRLSRQVEEFRRKVEPYGETYNKALVQQVEQFRQMLGPYAGNVEGHLSFLEKDLRDKVSSFFSTMKQKEIQPPADALPGQGQAPLES >XP_009245367.1 apolipoprotein A-IV [Pongo abelii] MFLKAVVLALALVAVTGARAEVQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEEVRARLLPHANEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAQRMERVLRENADSLHASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDAQEKLNHQLEGLAFQMKKNAEELKTRISASAEELRQRLAPLVEDVRGNLRGNTEGLQKSLAELGGHLDRQVEEFRSRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQTLSLPELEQQQAPLES >XP_003212771.2 apolipoprotein A-IV [Meleagris gallopavo] MSPKAAAFLLVLLAVAGTRADVQVATVLWKYFTELGSNAKETVDQLQQAEITKQLNTLLQSNLQSMNSYAEELQRRLVPFATELQAQLVQDSQRLKEQIQRELAELQAKLAPYADEVHQQIGTNIRELQAKLSPYADELRSQVDRGTGELRRALEPFATELRERLQDNAGSIQASLGSYTERLQQQIDSSVEGLKEQLTPLADELKEQVAQSVEGLRKGLSPYAQEVQDGLNRQLESLTMQMERAAEELRSRLAASSEEMRAQLSPLAQELQQALSADAEAVRQRLQQLDERLAQTVEAFRQQAAPISETFRQQLVQRLEEMKQKLDSGTAGVEDHLDLLEKEVREKVATFLSTTEQAES----------------- >XP_003820134.2 apolipoprotein A-IV [Pan paniscus] MFLKAVVLTLALVAVTGARAEVQVATVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHELLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLTPYAERMERVLRENAHSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQTLSLPELEQQQAPLES >XP_011284667.1 apolipoprotein A-IV [Felis catus] MFLRAVVLTLALVAVTGARAEVQVATVVWDYFSQLSNNAKEAVEHLQQSELTQQLNALFQDKLGQVNTYADNLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLGPYADELRTQVNTHAEHLRRHLTSHAQRMEAVLRENVDNLQSSLTPYADEFKAKIDQNIEELKGHLTPYADELKVKIDQNVEELRRSLAPYAQDVQEKLNHQLEGLAFQMKKNAEELKAKITANADELRQRLAPVAEDVRSKLRDNAKGLQESLAQLNSHLDRQVEEFRRNLGPYGDTFNRALVQQVEELRQKLGPYAGGMEDHLSFLEKDLRDKVNSFFITLKEKENQPLALPEQEQAPGPLES >XP_004016096.1 apolipoprotein A-IV [Ovis aries] MFLKAVVLSLALVAVTGAEAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHATEVSQKIGDNVRELQQRLGPYAEELRSQVDTQAQQLRRQLTPYAQRMETVMRQNLDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQGLVPVVNSVRGSQPGNAEGLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEIPVPLGG >XP_004052227.1 apolipoprotein A-IV [Gorilla gorilla gorilla] MFLKAVVLTLALVAVTGARAEVQVAMVMWDYFSQLSNNAKEAVEHLQKSELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIRKELEELRARLLPHANEVSQKIGDNVRELQQRLEPYADQLRTQVNTQAEQLRRQLIPYTERMERVLRENADSLRASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLAFQMKKNAEELKARISASAEELRQRLAPLAEDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPYAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQTLSLPELEQQQAPLES >XP_005689539.3 PREDICTED: apolipoprotein A-IV [Capra hircus] MFLKAVVLSLALVAVTGAEAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLKEEIRKELEELRARLLPHATEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTPYAERMETVMRQNLDQLQASLAPYAEELQATVNQRVEELKGHLTPYADQLQTKIEENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQGLVPVVNSVRGSQPGNAEGLQKSLAELSSRLDQQVEDFRRTVGPYGETFNKAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEEMPVPLGG >XP_014378547.1 apolipoprotein A-IV isoform X1 [Alligator sinensis] MSLKTLALVLALLAVAGGHAELQVANMVWSYLTNMRSSAQDTMDQFQESKLSKQINTLLQDKFENVQTYMADLQQKLSPFAAELQARMSQDSEKLKAQIRQELEELRAKLSPYADDVHQQITRNIQELQQKLAPYAEQLRGHVDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQAALAPYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQVESLSFQMKKAVEELQAQLARGTEELRGQLSPYTEELQ----GNSKRLRQTLEGLGERMDRIIDDFRQHVAPHGEAFNQKLVQKLEELRQKLGSDTGSVEDHLAFLERDLRQQLSSFLSSLKQIESS----PQDEQ------- >XP_006259584.3 PREDICTED: apolipoprotein A-IV isoform X1 [Alligator mississippiensis] MSLKTLALALALLAVAGSHAELQVANIVWSYFTDMRSSAQDTMDQIQESKLSKQINTLLQDKFANVQTYMADLQQKLIPFTAELQARMSQDSEKLKEQIRQELEELRAKLSPYADDVHQQITRNIQEMQKKLAPYAEQLRGHMDQNAEQLRQSLAPYAQKLQDQLQDNAGNLQAALAPYADQLQEQINSNVEGMKDRLASVTEDLKVKVDESMAELQKSLAPYAQDAQDKLARQVESLSFQMKKAVEELQAQLAHGTEELRGQLSPYTEELQ----GNGKRLRQTLEGLGERMDRIIDDFRQHIAPHGEAFNQKLVQKLEELRQKLGSDTSSVEDHLAFLERDLRQQLSSFLSSLKQIESS----PQDEQ------- >XP_020758261.1 apolipoprotein A-IV [Odocoileus virginianus texanus] MFLKAVVLSLALVAVTGAQAEVQVATVIWDYFSQLGNNAKKAVEHIQKSELTQQLNTLFQDKLGEVSTYTDDLQKKLVPFATELHERLTKDSEKLREEIRQELEELRARLLPHANEVSQKIGDNVRELQQRLGPYAEELRTQVDTQAQQLRRQLTVYAQRMETVMRQNMDQLQASVAPYAEELQATVDQRVEELKGRLTPYADQLQAKIDENVEELRRSLAPYAQDVQGKLNHQLEGLAFQMKKHAEELKAKISAKAEELRQRLVPVVSSVRGSQPGNAEGLQKSLAELSSHLEQQVEDFRRTVGPYGETFNRAMVQQLDALRQKLGPLAGDVEDHLSFLEKDLRDKVSSFFNTLKEKESQAPALPAQEDTPAPLGG
PhyML tree of selected proteins (XP_030268700_1_uncharacterized_protein_LOC115579335__Sparus_aurata_:0.32082872,XP_015829671_1_PREDICTED__apolipoprotein_A_IV_like__Nothobranchius_furzeri_:0.24219498,((XP_004078299_1_apolipoprotein_A_I_isoform_X2__Oryzias_latipes_:0.39774984,(tr_B3DHC5_B3DHC5_DANRE_Apolipoprotein_A_IV_b__tandem_duplicate_2_OS_Danio_rerio_OX_7955_GN_apoa4b_2_PE_1_SV_1:0.02939242,tr_Q3B7G4_Q3B7G4_DANRE_Apolipoprotein_A_IV_OS_Danio_rerio_OX_7955_GN_apoa4b_1_PE_2_SV_1:0.05095348):0.16849678):0.12125069,(XP_021140876_1_apolipoprotein_A_I__Columba_livia_:1.01322837,((((XP_003212771_2_apolipoprotein_A_IV__Meleagris_gallopavo_:0.03570296,NP_990269_1_apolipoprotein_A_IV_precursor__Gallus_gallus_:0.01906641):0.37149602,(XP_006259584_3_PREDICTED__apolipoprotein_A_IV_isoform_X1__Alligator_mississippiensis_:0.02415375,XP_014378547_1_apolipoprotein_A_IV_isoform_X1__Alligator_sinensis_:0.02461345):0.32802344):0.09906092,((((XP_009245367_1_apolipoprotein_A_IV__Pongo_abelii_:0.02208688,(sp_P06727_APOA4_HUMAN_Apolipoprotein_A_IV_OS_Homo_sapiens_OX_9606_GN_APOA4_PE_1_SV_4:0.01376386,(XP_004052227_1_apolipoprotein_A_IV__Gorilla_gorilla_gorilla_:0.0137473,(XP_522192_2_apolipoprotein_A_IV__Pan_troglodytes_:0.00272591,XP_003820134_2_apolipoprotein_A_IV__Pan_paniscus_:0.00547197):0.00000001):0.00272088):0.00000001):0.08687906,(XP_546510_3_apolipoprotein_A_IV__Canis_lupus_familiaris_:0.07415372,XP_011284667_1_apolipoprotein_A_IV__Felis_catus_:0.06689279):0.03953667):0.00833447,(NP_999553_1_apolipoprotein_A_IV_precursor__Sus_scrofa_:0.10191979,((XP_020758261_1_apolipoprotein_A_IV__Odocoileus_virginianus_texanus_:0.02241176,((XP_043338500_1_apolipoprotein_A_IV__Cervus_canadensis_:0.00000001,OWK18067_1_APOA4__Cervus_elaphus_hippelaphus_:0.00000001):0.01655361,(KAB0370821_1_hypothetical_protein_FD755_017230__Muntiacus_reevesi_:0.00243758,KAB0347353_1_hypothetical_protein_FD754_012210__Muntiacus_muntjak_:0.00292437):0.00270733):0.00254781):0.00721195,(XP_004016096_1_apolipoprotein_A_IV__Ovis_aries_:0.00473033,(XP_005215909_1_apolipoprotein_A_IV_isoform_X1__Bos_taurus_:0.02194738,XP_005689539_3_PREDICTED__apolipoprotein_A_IV__Capra_hircus_:0.00000001):0.00344307):0.02243107):0.12718805):0.04060436):0.03897428,(NP_001164881_1_apolipoprotein_A_IV_precursor__Oryctolagus_cuniculus_:0.2175528,(NP_031494_2_apolipoprotein_A_IV_precursor__Mus_musculus_:0.1208782,NP_036869_2_apolipoprotein_A_IV_precursor__Rattus_norvegicus_:0.07927649):0.29413268):0.02393235):0.31481805):0.09810205,(NP_001083577_1_uncharacterized_protein_LOC399000_precursor__Xenopus_laevis_:0.22531469,XP_040181291_1_apolipoprotein_A_IV_like__Rana_temporaria_:0.33047852):0.33233895):0.45848468):0.61477661):0.29995283);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)