PB0048

DATABASE

Click here to access PB0048 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0048	O43405	Cochlin	COCH	COCH-5B2, COCH5B2, DFNA9, DFNB110	Homo_sapiens	Plays a role in the control of cell shape and motility in the trabecular meshwork.

Domains

Gene Ontology

PF00092 (2_VWA) PF03815 (LCCL)

GO:0005515 (enables) protein binding GO:0005518 (enables) collagen binding GO:0007605 (involved in) sensory perception of sound GO:0008360 (involved in) regulation of cell shape GO:0042742 (involved in) defense response to bacterium GO:0045089 (involved in) positive regulation of innate immune response GO:0005576 (located in) extracellular region GO:0031012 (located in) extracellular matrix GO:0062023 (located in) collagen-containing extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|O43405|COCH_HUMAN Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1 MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG ICRDFLESQQ >tr|B3DFV8|B3DFV8_DANRE Cochlin OS=Danio rerio OX=7955 GN=coch PE=1 SV=1 MSLWFAVLHVLGILSLSWCTSGSELNVATPISCGTRAVDLSDTHLLVLCPANCSLWSLSV FGSGVYASISSICGAAIHRGIIGLSGGPVEVHGLQGRTNYLSSYAHGVQSQSLSQWSASF TVARTISLPLEVSSQTSSSATVASGAAKKPVKKIVKKPPPATAHKDCPVDMALLLDSSYN IGQRRFNLQKNFVSKLATMLKVGTQGPHVGVVQTSETPRTEFYLTNYTTAKDVTFAIKEI PYIGGNTNTGKAILHTVRNFFSPDFGVRRGYPRVIVVFVDGWPSDNVEEAAILARESGIN IFFVSVAKPSPEEASLVSDQDFMRKAVCKDNEFFTFTMPSWFSTNKFVKPLAQKLCSIDQ MLCSKTCYNSVDLGFLIDGSSSVGDGNFRLVLDLLVSIARSFDISDIGSRIGAIQFTYDQ RMEFNFNDHVLKDNALRALQKIPYMSGGTATGDAINFAVRSLFKPRSSSNRKFLIIITDG QSYDDVRVPAMAAQREGITVYAVGVAWAPMEDLKAMASEPKESHVFFTREFTGLGQFQQP IVRGICRDFTEFN
Selected proteins from model organisms >sp|O43405|COCH_HUMAN Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1 MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFS VYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSAS FTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRR FNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG NSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVS VAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSK TCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYD DVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRG ICRDFLESQQ >tr|B3DFV8|B3DFV8_DANRE Cochlin OS=Danio rerio OX=7955 GN=coch PE=1 SV=1 MSLWFAVLHVLGILSLSWCTSGSELNVATPISCGTRAVDLSDTHLLVLCPANCSLWSLSV FGSGVYASISSICGAAIHRGIIGLSGGPVEVHGLQGRTNYLSSYAHGVQSQSLSQWSASF TVARTISLPLEVSSQTSSSATVASGAAKKPVKKIVKKPPPATAHKDCPVDMALLLDSSYN IGQRRFNLQKNFVSKLATMLKVGTQGPHVGVVQTSETPRTEFYLTNYTTAKDVTFAIKEI PYIGGNTNTGKAILHTVRNFFSPDFGVRRGYPRVIVVFVDGWPSDNVEEAAILARESGIN IFFVSVAKPSPEEASLVSDQDFMRKAVCKDNEFFTFTMPSWFSTNKFVKPLAQKLCSIDQ MLCSKTCYNSVDLGFLIDGSSSVGDGNFRLVLDLLVSIARSFDISDIGSRIGAIQFTYDQ RMEFNFNDHVLKDNALRALQKIPYMSGGTATGDAINFAVRSLFKPRSSSNRKFLIIITDG QSYDDVRVPAMAAQREGITVYAVGVAWAPMEDLKAMASEPKESHVFFTREFTGLGQFQQP IVRGICRDFTEFN >NP_499400.2 Cuticlin-6 [Caenorhabditis elegans] MRPIPYDISLSITSFLSLILICSANPIDNGLVDSELIHECVTHKAVEVILLLDASGSIGDDTFKKQLSFAMHLASRLNIS EDGSHMALIQYAETPKLEFSLGQFNHPTQLEWAIQRIEYQSGATNTGQALRLTLEKGLQGARPGIPKVAIVITDGQSQDD VSEPSQLLRDADVMVYAIGVTNLVNVHQLHQMTGNPVRVFTVESFEQLDRALADSLTWSMCKTEFRPGTPEIICGPDRIG VKASTKQPFEGNVFVMDHYHDEECRAGPEKFPDSRSIGLTVPFSACNVHRYRSLNPKGIFVEVSIVFMFHSLFMTKTDQT VKVQCFYMEADKHVTVPLSVSMITTVFREQIYQMPQCAYTLRKGAPDGPIVRFATLGESVYHRWECIEVEGADKDTFGML VHSCYVDNGYGDRVDILDSNGCGLDAVLLSTPDYDTSLRLATKPYHVFKYADRPVLQFQCQITLCLKYDGGCEGITPPQN CKKLPGEDGHHHHHHPEKRRKLVRRLADGVGTIDVFTDSVTVLEQEPACQQPLPYPLINTNLWIMGIITLTNIFVFILTV WFTFRKRRCKPA >NP_001185764.1 cochlin precursor [Mus musculus] MPSSRIPALCLGAWLLLLLLPRFARAEGAVPIPVTCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYA SVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFAVTKGKSSTQEATGRAV STAHPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQ ASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWP SDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQ KLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTE FSFTDYNTKENVLAVLANIRYMSGGTATGDAIAFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAA AHDAGITIFSVGVAWAPLDDLRDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >NP_001102180.2 cochlin precursor [Rattus norvegicus] MPSSWSPALCLGAWLLLLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYA SVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAV STANPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGVGTEGPHVGLVQ ASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWP SDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQ KLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTE FSFTDYNTKENVLAVLANIRYMSGGTATGDAISFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAA AHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_015142770.2 cochlin isoform X1 [Gallus gallus] MPAPSLAPTPAALACPVPMRPGRGLRRARRQLRHSAAEVPPGEDVGWAAPRLPSRPGACPAAMQFAPLLL GVFLLCGSACGSDSSASNAITCFTRGLDLRKETEDVLCPANCPLWQFYVFGDGIYASLSSVCGAAIHRGV ITNAGGAVRVQTLPGQENYPAVHANGIQSQVLSRWASSFSVTRTNNLALEAVGRSVATARPATGKRPKKT LEKKAGNKDCKADIAFLIDGSYNIGQRRFNLQKNFVGKVAVMLGIGTEGPHVGVVQASEHPKIEFYLKNF TAAKEVLFAIKELGFRGGNSNTGKALKHAAQKFFSMENGARKGIPKIIVVFLDGWPSDDLEEAGIVAREF GVNVFIVSVAKPTTEELGMVQDIGFIDKAVCRNNGFFSYQMPSWFGTTKYVKPLVQKLCSHEQMLCSKTC YNSVNIGFLIDGSSSVGESNFRLMLEFISNVAKAFEISDIGSKIATVQFTYDQRTEFSFTDYTTKEKVLS AIRNIRYMSGGTATGDAISFTTRNVFGPVKDGANKNFLVILTDGQSYDDVRGPAVAAQKAGITVFSVGVA WAPLDDLKDMASEPRESHTFFTREFTGLEQMVPDVIRGICKDFLDSKQ >XP_001171057.1 cochlin [Pan troglodytes] MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASV SSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVST AHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_547762.4 cochlin [Canis lupus familiaris] MSAAWIPVLGLGVCLLLLLPEPAGSDGAVPIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYAS VSSICGAAVHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVS TARPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA SEHPKIEFYLKNFTSPKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRRGIPKVVVVFIDGWPS DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFIDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQK LCSHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFHLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEF SFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAA HDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >NP_001071310.1 cochlin precursor [Bos taurus] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIPITCSTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASV SSICGAAVHRGVIGHSGGPVRIYSLPGRENYSSVVANGIQSQMLSRWSASFTVTKGKSGTQEATGQAVST AHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVAFRGGNSNTGKALKHTAQKFFTADTGARKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLKFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNISYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_002718170.1 PREDICTED: cochlin [Oryctolagus cuniculus] MSAAWLPALCLGVCLLLPLPEPAGSEGAVPLAITCTTRGLDIRKEKADVLCPAGCPLEEFSVFGNIVYAA VSSICGAAIHRGVIGTSGGPVRVYSLPGRENYSSADANGVRSQTLSRWSASFTVTKGKSSTQEATGRAVS TARPPAGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA SEHPKIEFYLKNFTTAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPS DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQK LCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEF SFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIITDGQSYDDVRGPAAAA HDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >KAF4017973.1 hypothetical protein G4228_009522 [Cervus hanglu yarkandensis] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHR GVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNK DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG NSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDK AVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEIS DIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYD DVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_043345758.1 cochlin isoform X2 [Cervus canadensis] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHR GVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNK DCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGG NSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDK AVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEIS DIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPHKNFLVIVTDGQSYD DVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >OWK08714.1 COCH [Cervus elaphus hippelaphus] MQHSSIKSVKCPCKSLDRTQLLFLCCRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEA TGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHP KIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFG VNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLID GSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFT VRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPI VSDVIRGICRDFLESQQ >XP_018086673.1 cochlin [Xenopus laevis] MMHFILYTLAVSCICVQLAATIAPGESSIPVTCSMRALDLKKELVQVLCPPGCAEQQLSVYGDGIYAAVSSICGAALHRG VLPKNGGMINVHRLPGQQDYPASSANGIQSQSLSRWTSSFSVSKAVSQGLEVSGKPVASQVASTKRLKKTPQKLTGNKDC KAEIAFVIDGSNNIGQRRFNLQKNFVARVSMLLGIGTDGPHVGVVQASEVPKTEFLLKNFTAPRDVQFAVKEISFRGGNS NTGKAIKHTAQNFFTTANGVRKGIPKVMVVFIDGWPSDNIEEAGIVAREFGINVFIVSVAPPAAEELGMVQDIAFIDKAV CRNSSYFSYHVPGWFGTAKHAKPLMQKLCSHEHLLCSKTCYNSVNIGFLIDGSSSVGDLNFRMMLDFMADVVRAFEVSDV GTKVGAVQFTYDQRLEFGLNDHSNKDDVLNALRNIRYMSGGTATGDAINFAVRNLFQPTKDGHNKNFLIIITDGQSYDDV RGPASSAHTSGVTVFSVGVAWAPMEDLKDMASEPKNSHTFFTREFPGLEQITSDLIRGICRDYLDSHK >XP_030247842.1 cochlin [Sparus aurata] MSRLSVLLPLTGLLFLMSSTLGSQSSVAFPVTCATRGAELTENSVLVLCPPDCTRGRVPVFGTGIYASVSTVCGAAVHRG LLGPSGGPVRVHKQKGQINYVSSYAHGIQSQALARWTASFSLSKPVNVPLELTSDTSTTALPAAAQPAKKPVKKTSAKKP PTGGNKDCQMDIAMVIDSSNNIGQRRFNLQKNFVAKLAAMLRVGQTGPRVGLIQASDSPRTEFLLSNFTQPKELLFAIKE LAYLGGDTNTGKAIMHTAESFFTQENGGRRGHPRVMMVLIDGWPSDDLEQAAMLARESGINVFLVSVAKPAPEELSMVRD KDFTRKAVCKDNGFFTYSIPSWFSTTKHVKPLSQRLCALDSLLCSKTCYNSVNIGFLIDGSSSVGDGNFQLVLDFLAGIA RSFDISDVGARIGAVQFTYDQRLEFGLYDHSTKDDAINALKRISYMSGGTATGGAISYATQNLFRRTGPGRNFLIVVTDG QSYDDVMRPAAAAQKQGITMFSVGVAWAPLDDLRAMASEPKDGHTFFTREFTGLADFVPPLVRGICRDFTENN >XP_024087351.1 cochlin [Pongo abelii] MSAAWIPALGLGVCLLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYAS VSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVS TAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA SEQPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPS DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQK LCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEF SFTDYSTKENVLAAIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAA HDAGITVFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_020955555.1 cochlin [Sus scrofa] MSAAWIPVLCLGVCLLLLLPEPAGSEGAVPIPITCFTRGLDIRKEQADVLCPGGCLLEEFSVFGNIVYAS VSSVCGAAVHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVS TARPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQA SEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTAETGVRKGIPKVVVVFIDGWPS DDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQK LCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEF SFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRESPNKNFLVIVTDGQSYDDVRGPAAAA HDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_008972946.1 cochlin [Pan paniscus] MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASV SSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVST AHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_011281477.1 cochlin [Felis catus] MSAAWIPVLCLGVCLLLLPEPAGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASV SSICGAAIHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVST ARPSTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADAGVRRGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFT FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_027813031.1 cochlin [Ovis aries] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASV SSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAVST AHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRREFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_004055095.1 cochlin isoform X1 [Gorilla gorilla gorilla] MSAAWIPALGLGVCLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASV SSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVST AHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_020569538.1 cochlin isoform X1 [Oryzias latipes] MSLSSVLLTGFLIFLSALESGSSGEQKGSVFGTRSSQERNLRRSADGELCLSDVDPVSCETRGSDLELDD VVVLCPPGCRRTRMSVFGTGPYAAVSSVCGAALHRGALGPSGGPVRVLKQRGQHSYVSSYANGIQSLGLS RWTSSFSLSESIHPPLEFIAETRTTSLPAGAQPAKKALKKPSLVKKVLAGGNKDCQMDVAVVMDSSRNIG QRRFNLQKNFVAKLAAMLRVGASGPRVGLIQASDSPKTEFVLSSYTQPKDLLFAIKELTFLGGDSNTGKA ILHTAETFFTQENGMRRGHPRVMVVMIDGWPSDDVEQAAILARESGINVFLVSVAKPAAEELSMVADRDF MKKAVCKDNGFFSYSIPSWFSTTKHARSVTQRLCSLDSLLCSKTCYNSVNIGFLIDGSSSVGMDNFKMVL DFLAGIAQSFDISDIGSRVGAVQFTYDQRMEFGLFDHSTKEDTMNALRGISYMSGGTSTGSAISYATQNL FRHPRRGHDFLVVVTDGQSYDDIRGPAMAAQRQGITIFSVGVAWAPLDDLRAMSSEPKDRHTLFTREFTG LLDFIPLVVRSICQDFTEISEIRP >XP_017921374.1 PREDICTED: cochlin [Capra hircus] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHVVYASV SSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAVST AHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRREFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_025058265.1 cochlin [Alligator sinensis] MEISPPCTGLSGISSQGRGWTAVSFVGWRLSGLAISAFTFTAITCFTRGLDLRKEREDVLCPANCPLWQF HVYGNGVYASLSSICGAAIHSGVITTSGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSV ALAAAGQPVSTARPSTGKRPKKPLEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNLVGKISVMLGIGA EGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKALKFTAQRFFSMDNGARKGIPKI IIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPTPEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGT TKYVKPLAQKLCTHEQMLCSKTCYNSINIAFLIDGSSSVGDSNFALMLEFISNVAKAFEISDIGSRIAAV QFTYDQRSEFIFSDYTTKEKVLTAIRNIRYMSGGTATGEAISFTNKNVFEPVKNGPNKNFLVILTDGQSY DDVRGPAAAAHKAGITVFSIGIAWAPLDDLKAMASEPRDTHTFFTREFTGLEQIVTDVTRGICRDFLDSN Q >XP_019344348.1 PREDICTED: cochlin isoform X1 [Alligator mississippiensis] MEISPPCTGLSGISSQGRGWTAVSFVGWRLSGLAISAFTLTAITCFTRGLDLRKEREDVLCPANCPLWQF HVYGNGVYASLSSICGAAIHSGVVTSTGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSV ALAAAGQPVSTARPSTGKRPKKPLEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNLVGKISVMLGIGA EGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKALKFTAQRFFSMDNGARKGIPKI IIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPTPEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGT TKYVKPLAQKLCTHEQMLCSKTCYNSINIAFLIDGSSSVGDSNFALMLEFISNVAKAFEISDIGSRIAAV QFTYDQRSEFIFSDYTTKEKVLTAIRNIRYMSGGTATGEAISFTNKNVFEPVKNGPNKNFLVILTDGQSY DDVRGPAAAAHKAGITVFSIGIAWAPLDDLKAMASEPRDTHTFFTREFTGLEQIVTDVTRGICRDFLDSN Q >XP_015824907.1 PREDICTED: cochlin [Nothobranchius furzeri] MSHLYFLLPLTGLLFFIPSYSSRSNGLYPVSCETRGSDLKQDEVLVLCPPDCLQVRPSVFGSDVYAAISS ICGAAVHRGILGPSGGPVRLQKQQGRRSYVSSYANGIHSQALHQWTASFHLSKTVDAPLELTNSARATAQ PAATRPEKKAMKSSVKQGENKDCQMDIAIIMDSSSNIGQRRFNLQKNFVTKLAAMLRVGPTGPHLGLIQT SDSPRTEFLLTNFTKPKELLFAIKELKYLGGDTNTGKAIMHAAEVFFTPGNGVRRGHPRVMMVLIDGWPS DDVERAAMLARESGINVFMVSVSKPAAEELSMVQDKDFLKKAVCKDNGFFSYSIPSWFSNNKHVRPLAQR LCSLDDLLCSKTCYNSVNIGFLIDGSSSVGWQNFQLVLDFLAGIAQSFDISDVGAHIGAVQFTYEQRVEF GLLDHSNKEDAVRALRRISYMNGGTATGSAISYATQNLFRQAARGRNYLIVITDGQSYDDVQGPAMAAQR QGITIFSVGVAWAPMKELLDMASEPKDKHTFFTREFVNLSEFIQPLVRGICQAFTENN >XP_020732458.1 cochlin [Odocoileus virginianus texanus] MWASWIPVLCLGVCLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASV SSICGAAVHRGVIGNSGGPVRVYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVST AHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQAS EHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSD DIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKL CTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFS FTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAH DAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDVIRGICRDFLESQQ >XP_040189331.1 cochlin [Rana temporaria] MLSLHTIFVILGIIVQSASGDPGAGESPVPITCSMRGMDLKKESAQVLCPPGCNTQHVSVYGDGVYAGVS SVCGAAHHRGVISSNGGPLSLRRLPGQQNYAAVLANGVQSQPLTKWTSSFSVSKQKSRGMEVSGKPVSTS TTRRQKKTPQKSTGNKDCKAEIAFLMDGSNNIGQRRFNLQKNFVAKVALMLGIGTDGPHVGVVQTSELPK TEFFLKNFTSAKDVVFAVKEINFKGGNSNIGKAIKHTAQTFFSISNGVRKGIPKVMVVFIDGWPSDNIEE AGIIAREYGINVFIVSVAPPSPEELGMVQDVAFIDKAVCKNNSFFSFHMPSWFGTAKYTKPLVQKLCTHE QLLCSKTCYNSVNIAFLIDGSSSIGDQNFRIMLDFITNIVRAFEVSDVGAKVAAVQFTYDQRLEFGLNDY STKEDVLRATNNIPYMSGGTATGDAINFVLRSVFQPTKDGPNKNFLVLITDGQSYDDVRGPALAAHREGV TVYSVGVAWAPLDDLKDMASEPKNSHTFFSREFPGLEQIVPSIIRGICRDYLDSQK
Mafft alignment of selected proteins >sp|O43405|COCH_HUMAN Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1 M----------------------------------------------------------- SAAWIPALGLGV-------------C-LLLLPGPAGSEGAA------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAV HRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAV STAHPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----IRESPNKNFLVIVTDGQSYDDVQGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >tr|B3DFV8|B3DFV8_DANRE Cochlin OS=Danio rerio OX=7955 GN=coch PE=1 SV=1 M----------------------------------------------------------- SLWFAVLHVLGI---------------LSLSWCTSGSELNV------------------- ----------ATPISCGTRAVDLSDTHLLVLCPANCSLWSLSVFGSGVYASISSICGAAI HRGIIGLSGGPVEVHGLQGRTNYLSSYAHGVQSQSLSQWSASFTVARTISLPLEVSSQTS SSATVASGAAKKPVKKIVKKPP-----PATAHKDCPVDMALLLDSSYNIGQRRFNLQKNF VSKLATMLKVGTQGPHVGVVQTSETPRTEFYLTNYTTAKDVTFAIKEIPYIGGNTNTGKA ILHTVRNFFSPDFGVRRGYPRVIVVFVDGWPSDNVEEAAILARESGINIFFVSVAKPS-- ---------PEEASLVSDQDFMRKAVCKDNEFFTFTMPSWFSTNKFVKPLAQKLCSIDQM LCSKTCY--------------------------NSVDLGFLIDGSS-------SVGDGNF RLVLDLLVSIARSFDI-SDIGSRIGAIQFTYDQRMEFNFN----DHVLKDNALRALQKIP YMSGGTATGDAINFAV--RSLFKP-----RSSSNRKFLIIITDGQSYDDVRVPAM-AAQR EGITVYAVGVAWAPMEDLKAMASEPKESHVF---------FTREFT-------GLGQFQQ P-----------------------IVR------GICRDFTEFN----------------- ----------------------------------- >NP_499400.2 Cuticlin-6 [Caenorhabditis elegans] MR---------------------------------------------------------- ------------------------------------------------------------ ----------PIP----------------------------------------------- --------------------------------------YDISLSITSFLSLILICSANPI --------------DNGLVDSELIH--ECVTHK--AVEVILLLDASGSIGDDTFKKQLSF AMHLASRLNISEDGSHMALIQYAETPKLEFSLGQFNHPTQLEWAIQRIEYQSGATNTGQA LRLTLEKGL---QGARPGIPKVAIVITDGQSQDDVSEPSQLLRDADVMVYAIGVTNLVNV HQLHQMTGNPVRVFTVESFEQLDRALADS---LTWSM----CKTEFRPGTPEIICGPDRI GVKASTKQPFEGNVFVMDHYHDEECRAGPEKFPDSRSIGLTVPFSACNVHRYRSLNPKGI FVEVSIVFMFHSLFMTKTDQTVKVQCFYMEADKHVTVPLSVSMITTVFREQIYQMPQCAY TLRKGAPDGPIVRFATLGESVYHRWECIEVEGADKDTFGMLVHSCYVDNGYGDRVDILDS NGCGLDAVLLSTPDYDTSLRLATKP--YHVFKYADRPVLQFQCQITLCLKYDGGCEGITP PQNCKKLPGEDGHHHHHHPEKRRKLVRRLADGVGTIDVFTDSVTVLEQEPACQQPLPYPL INTNLWIMGIITLTNIFVFILTVWFTFRKRRCKPA >NP_001185764.1 cochlin precursor [Mus musculus] M----------------------------------------------------------- PSSRIPALCLGA---------W---LLLLLLPRFARAEGAV------------------- ----------PIPVTCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAV HRGVIGTSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFAVTKGKSSTQEATGRAV STAHPPSG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYNTKENVLAVLANIR YMSGGTATGDAIAFTV--RNVFGP----IRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLRDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >NP_001102180.2 cochlin precursor [Rattus norvegicus] M----------------------------------------------------------- PSSWSPALCLGA---------W---LLLLLLPRLARAEGAV------------------- ----------PIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAV HRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAV STANPPSG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGVGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYNTKENVLAVLANIR YMSGGTATGDAISFTV--RNVFGP----IRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_015142770.2 cochlin isoform X1 [Gallus gallus] MPAPSLAPTPAALACPVPMRPGRGLRRARRQLRHSAAEVPPGEDVGWAAPRLPSRPGACP AAMQFAPLLLGV---------------FLLCGSACGSDSSA------------------- ----------SNAITCFTRGLDLRKETEDVLCPANCPLWQFYVFGDGIYASLSSVCGAAI HRGVITNAGGAVRVQTLPGQENYPAVHANGIQSQVLSRWASSFSVTRTNNLALEAVGRSV ATARPATG------KRPKKTLE-----KKAGNKDCKADIAFLIDGSYNIGQRRFNLQKNF VGKVAVMLGIGTEGPHVGVVQASEHPKIEFYLKNFTAAKEVLFAIKELGFRGGNSNTGKA LKHAAQKFFSMENGARKGIPKIIVVFLDGWPSDDLEEAGIVAREFGVNVFIVSVAKPT-- ---------TEELGMVQDIGFIDKAVCRNNGFFSYQMPSWFGTTKYVKPLVQKLCSHEQM LCSKTCY--------------------------NSVNIGFLIDGSS-------SVGESNF RLMLEFISNVAKAFEI-SDIGSKIATVQFTYDQRTEFSFT----DYTTKEKVLSAIRNIR YMSGGTATGDAISFTT--RNVFGP----VKDGANKNFLVILTDGQSYDDVRGPAV-AAQK AGITVFSVGVAWAPLDDLKDMASEPRESHTF---------FTREFT-------GLEQMVP D-----------------------VIR------GICKDFLDSKQ---------------- ----------------------------------- >XP_001171057.1 cochlin [Pan troglodytes] M----------------------------------------------------------- SAAWIPALGLGV-------------C-LLLLPGPAGSEGAA------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAV HRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAV STAHPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----IRESPNKNFLVIVTDGQSYDDVQGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_547762.4 cochlin [Canis lupus familiaris] M----------------------------------------------------------- SAAWIPVLGLGV-------------CLLLLLPEPAGSDGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAV HRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STARPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSPKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRRGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFIDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCSHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF HLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----VRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >NP_001071310.1 cochlin precursor [Bos taurus] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIPITCSTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAV HRGVIGHSGGPVRIYSLPGRENYSSVVANGIQSQMLSRWSASFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVAFRGGNSNTGKA LKHTAQKFFTADTGARKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLKFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIS YMSGGTATGDAISFTV--RNVFGP----VRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_002718170.1 PREDICTED: cochlin [Oryctolagus cuniculus] M----------------------------------------------------------- SAAWLPALCLGV-------------CLLLPLPEPAGSEGAV------------------- ----------PLAITCTTRGLDIRKEKADVLCPAGCPLEEFSVFGNIVYAAVSSICGAAI HRGVIGTSGGPVRVYSLPGRENYSSADANGVRSQTLSRWSASFTVTKGKSSTQEATGRAV STARPPAG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTTAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----VRDSPNKNFLVIITDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >KAF4017973.1 hypothetical protein G4228_009522 [Cervus hanglu yarkandensis] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAV HRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_043345758.1 cochlin isoform X2 [Cervus canadensis] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAV HRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPHKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >OWK08714.1 COCH [Cervus elaphus hippelaphus] M----------------------------------------------------------- QHSSIK------------------------------------------------------ ------------SVKCPCKSLD--RTQLLFLC-----------------------C---- -RGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_018086673.1 cochlin [Xenopus laevis] M----------------------------------------------------------- --MHFILYTLAV-------------SCICVQLAATIAPGES------------------- ----------SIPVTCSMRALDLKKELVQVLCPPGCAEQQLSVYGDGIYAAVSSICGAAL HRGVLPKNGGMINVHRLPGQQDYPASSANGIQSQSLSRWTSSFSVSKAVSQGLEVSGKPV AS-QVAST------KRLKKTPQ-----KLTGNKDCKAEIAFVIDGSNNIGQRRFNLQKNF VARVSMLLGIGTDGPHVGVVQASEVPKTEFLLKNFTAPRDVQFAVKEISFRGGNSNTGKA IKHTAQNFFTTANGVRKGIPKVMVVFIDGWPSDNIEEAGIVAREFGINVFIVSVAPPA-- ---------AEELGMVQDIAFIDKAVCRNSSYFSYHVPGWFGTAKHAKPLMQKLCSHEHL LCSKTCY--------------------------NSVNIGFLIDGSS-------SVGDLNF RMMLDFMADVVRAFEV-SDVGTKVGAVQFTYDQRLEFGLN----DHSNKDDVLNALRNIR YMSGGTATGDAINFAV--RNLFQP----TKDGHNKNFLIIITDGQSYDDVRGPAS-SAHT SGVTVFSVGVAWAPMEDLKDMASEPKNSHTF---------FTREFP-------GLEQITS D-----------------------LIR------GICRDYLDSHK---------------- ----------------------------------- >XP_030247842.1 cochlin [Sparus aurata] M----------------------------------------------------------- SRLSVLLPLTGL---------------LFLMSSTLGSQSSV------------------- ----------AFPVTCATRGAELTENSVLVLCPPDCTRGRVPVFGTGIYASVSTVCGAAV HRGLLGPSGGPVRVHKQKGQINYVSSYAHGIQSQALARWTASFSLSKPVNVPLELTSDTS TTALPAAA---QPAKKPVKKTS-AKKPPTGGNKDCQMDIAMVIDSSNNIGQRRFNLQKNF VAKLAAMLRVGQTGPRVGLIQASDSPRTEFLLSNFTQPKELLFAIKELAYLGGDTNTGKA IMHTAESFFTQENGGRRGHPRVMMVLIDGWPSDDLEQAAMLARESGINVFLVSVAKPA-- ---------PEELSMVRDKDFTRKAVCKDNGFFTYSIPSWFSTTKHVKPLSQRLCALDSL LCSKTCY--------------------------NSVNIGFLIDGSS-------SVGDGNF QLVLDFLAGIARSFDI-SDVGARIGAVQFTYDQRLEFGLY----DHSTKDDAINALKRIS YMSGGTATGGAISYAT--QNLFR------RTGPGRNFLIVVTDGQSYDDVMRPAA-AAQK QGITMFSVGVAWAPLDDLRAMASEPKDGHTF---------FTREFT-------GLADFVP P-----------------------LVR------GICRDFTENN----------------- ----------------------------------- >XP_024087351.1 cochlin [Pongo abelii] M----------------------------------------------------------- SAAWIPALGLGV-------------CLLLLLPGPAGSEGAA------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAV HRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAV STAHPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEQPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAAIRNIR YMSGGTATGDAISFTV--RNVFGP----IRESPNKNFLVIVTDGQSYDDVQGPAA-AAHD AGITVFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_020955555.1 cochlin [Sus scrofa] M----------------------------------------------------------- SAAWIPVLCLGV-------------CLLLLLPEPAGSEGAV------------------- ----------PIPITCFTRGLDIRKEQADVLCPGGCLLEEFSVFGNIVYASVSSVCGAAV HRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STARPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTAETGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----VRESPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_008972946.1 cochlin [Pan paniscus] M----------------------------------------------------------- SAAWIPALGLGV-------------C-LLLLPGPAGSEGAA------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAV HRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAV STAHPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----IRESPNKNFLVIVTDGQSYDDVQGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_011281477.1 cochlin [Felis catus] M----------------------------------------------------------- SAAWIPVLCLGV-------------C-LLLLPEPAGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAI HRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STARPSTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADAGVRRGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFTFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----VRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_027813031.1 cochlin [Ovis aries] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAV HRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRREFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_004055095.1 cochlin isoform X1 [Gorilla gorilla gorilla] M----------------------------------------------------------- SAAWIPALGLGV-------------C-LLLLPGPAGSEGAA------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAV HRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAV STAHPPTG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGDSNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----IRESPNKNFLVIVTDGQSYDDVQGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_020569538.1 cochlin isoform X1 [Oryzias latipes] M----------------------------------------------------------- SLSSVL--LTGF---------------LIFLSA-LESGSSGEQKGSVFGTRSSQERNLRR SADGELCLSDVDPVSCETRGSDLELDDVVVLCPPGCRRTRMSVFGTGPYAAVSSVCGAAL HRGALGPSGGPVRVLKQRGQHSYVSSYANGIQSLGLSRWTSSFSLSESIHPPLEFIAETR TTSLPAGA---QPAKKALKKPSLVKKVLAGGNKDCQMDVAVVMDSSRNIGQRRFNLQKNF VAKLAAMLRVGASGPRVGLIQASDSPKTEFVLSSYTQPKDLLFAIKELTFLGGDSNTGKA ILHTAETFFTQENGMRRGHPRVMVVMIDGWPSDDVEQAAILARESGINVFLVSVAKPA-- ---------AEELSMVADRDFMKKAVCKDNGFFSYSIPSWFSTTKHARSVTQRLCSLDSL LCSKTCY--------------------------NSVNIGFLIDGSS-------SVGMDNF KMVLDFLAGIAQSFDI-SDIGSRVGAVQFTYDQRMEFGLF----DHSTKEDTMNALRGIS YMSGGTSTGSAISYAT--QNLFR------HPRRGHDFLVVVTDGQSYDDIRGPAM-AAQR QGITIFSVGVAWAPLDDLRAMSSEPKDRHTL---------FTREFT-------GLLDFIP L-----------------------VVR------SICQDFTEISEI--------------- --------------------------------RP- >XP_017921374.1 PREDICTED: cochlin [Capra hircus] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHVVYASVSSICGAAV HRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRREFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_025058265.1 cochlin [Alligator sinensis] M----------------------------------------------------------- ---EISPPCTGLSGISSQGRGWTAVSFVGWRLSGLAISAFT------------------- ----------FTAITCFTRGLDLRKEREDVLCPANCPLWQFHVYGNGVYASLSSICGAAI HSGVITTSGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSVALAAAGQPV STARPSTG------KRPKKPLE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNL VGKISVMLGIGAEGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKA LKFTAQRFFSMDNGARKGIPKIIIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPT-- ---------PEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGTTKYVKPLAQKLCTHEQM LCSKTCY--------------------------NSINIAFLIDGSS-------SVGDSNF ALMLEFISNVAKAFEI-SDIGSRIAAVQFTYDQRSEFIFS----DYTTKEKVLTAIRNIR YMSGGTATGEAISFTN--KNVFEP----VKNGPNKNFLVILTDGQSYDDVRGPAA-AAHK AGITVFSIGIAWAPLDDLKAMASEPRDTHTF---------FTREFT-------GLEQIVT D-----------------------VTR------GICRDFLDSNQ---------------- ----------------------------------- >XP_019344348.1 PREDICTED: cochlin isoform X1 [Alligator mississippiensis] M----------------------------------------------------------- ---EISPPCTGLSGISSQGRGWTAVSFVGWRLSGLAISAFT------------------- ----------LTAITCFTRGLDLRKEREDVLCPANCPLWQFHVYGNGVYASLSSICGAAI HSGVVTSTGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSVALAAAGQPV STARPSTG------KRPKKPLE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNL VGKISVMLGIGAEGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKA LKFTAQRFFSMDNGARKGIPKIIIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPT-- ---------PEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGTTKYVKPLAQKLCTHEQM LCSKTCY--------------------------NSINIAFLIDGSS-------SVGDSNF ALMLEFISNVAKAFEI-SDIGSRIAAVQFTYDQRSEFIFS----DYTTKEKVLTAIRNIR YMSGGTATGEAISFTN--KNVFEP----VKNGPNKNFLVILTDGQSYDDVRGPAA-AAHK AGITVFSIGIAWAPLDDLKAMASEPRDTHTF---------FTREFT-------GLEQIVT D-----------------------VTR------GICRDFLDSNQ---------------- ----------------------------------- >XP_015824907.1 PREDICTED: cochlin [Nothobranchius furzeri] M----------------------------------------------------------- SHLYFLLPLTGL---------------LFFIPS-YSSRSNG------------------- ----------LYPVSCETRGSDLKQDEVLVLCPPDCLQVRPSVFGSDVYAAISSICGAAV HRGILGPSGGPVRLQKQQGRRSYVSSYANGIHSQALHQWTASFHLSKTVDAPLELTNSAR ATAQPAAT---RPEKKAMKSSV-----KQGENKDCQMDIAIIMDSSSNIGQRRFNLQKNF VTKLAAMLRVGPTGPHLGLIQTSDSPRTEFLLTNFTKPKELLFAIKELKYLGGDTNTGKA IMHAAEVFFTPGNGVRRGHPRVMMVLIDGWPSDDVERAAMLARESGINVFMVSVSKPA-- ---------AEELSMVQDKDFLKKAVCKDNGFFSYSIPSWFSNNKHVRPLAQRLCSLDDL LCSKTCY--------------------------NSVNIGFLIDGSS-------SVGWQNF QLVLDFLAGIAQSFDI-SDVGAHIGAVQFTYEQRVEFGLL----DHSNKEDAVRALRRIS YMNGGTATGSAISYAT--QNLFR------QAARGRNYLIVITDGQSYDDVQGPAM-AAQR QGITIFSVGVAWAPMKELLDMASEPKDKHTF---------FTREFV-------NLSEFIQ P-----------------------LVR------GICQAFTENN----------------- ----------------------------------- >XP_020732458.1 cochlin [Odocoileus virginianus texanus] M----------------------------------------------------------- WASWIPVLCLGV-------------C-LLLPPEPVGSEGAV------------------- ----------PIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAV HRGVIGNSGGPVRVYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAV STAHPATG------KRLKKTPE-----KKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNF VGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKA LKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPI-- ---------PEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQM MCSKTCY--------------------------NSVNIAFLIDGSS-------SVGESNF RLMLEFVSNIAKTFEI-SDIGAKIAAVQFTYDQRTEFSFT----DYSTKENVLAVIRNIR YMSGGTATGDAISFTV--RNVFGP----MRDSPNKNFLVIVTDGQSYDDVRGPAA-AAHD AGITIFSVGVAWAPLDDLKDMASKPKESHAF---------FTREFT-------GLEPIVS D-----------------------VIR------GICRDFLESQQ---------------- ----------------------------------- >XP_040189331.1 cochlin [Rana temporaria] M----------------------------------------------------------- LSLHTIFVILGI---------------IVQSASGDPGAGES------------------- ----------PVPITCSMRGMDLKKESAQVLCPPGCNTQHVSVYGDGVYAGVSSVCGAAH HRGVISSNGGPLSLRRLPGQQNYAAVLANGVQSQPLTKWTSSFSVSKQKSRGMEVSGKPV ST---STT------RRQKKTPQ-----KSTGNKDCKAEIAFLMDGSNNIGQRRFNLQKNF VAKVALMLGIGTDGPHVGVVQTSELPKTEFFLKNFTSAKDVVFAVKEINFKGGNSNIGKA IKHTAQTFFSISNGVRKGIPKVMVVFIDGWPSDNIEEAGIIAREYGINVFIVSVAPPS-- ---------PEELGMVQDVAFIDKAVCKNNSFFSFHMPSWFGTAKYTKPLVQKLCTHEQL LCSKTCY--------------------------NSVNIAFLIDGSS-------SIGDQNF RIMLDFITNIVRAFEV-SDVGAKVAAVQFTYDQRLEFGLN----DYSTKEDVLRATNNIP YMSGGTATGDAINFVL--RSVFQP----TKDGPNKNFLVLITDGQSYDDVRGPAL-AAHR EGVTVYSVGVAWAPLDDLKDMASEPKNSHTF---------FSREFP-------GLEQIVP S-----------------------IIR------GICRDYLDSQK---------------- -----------------------------------
BMGE Cleaned alignment of selected proteins >sp|O43405|COCH_HUMAN Cochlin OS=Homo sapiens OX=9606 GN=COCH PE=1 SV=1 SAAWIPALGLGVLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >tr|B3DFV8|B3DFV8_DANRE Cochlin OS=Danio rerio OX=7955 GN=coch PE=1 SV=1 SLWFAVLHVLGILSLSWCTSGSELNVATPISCGTRAVDLSDTHLLVLCPANCSLWSLSVFGSGVYASISSICGAAIHRGIIGLSGGPVEVHGLQGRTNYLSSYAHGVQSQSLSQWSASFTVARTISLPLEVSSQTSSSATVASGKKIVKKPPPATAHKDCPVDMALLLDSSYNIGQRRFNLQKNFVSKLATMLKVGTQGPHVGVVQTSETPRTEFYLTNYTTAKDVTFAIKEIPYIGGNTNTGKAILHTVRNFFSPDFGVRRGYPRVIVVFVDGWPSDNVEEAAILARESGINIFFVSVAKPSPEEASLVSDQDFMRKAVCKDNEFFTFTMPSWFSTNKFVKPLAQKLCSIDQMLCSKTCYNSVDLGFLIDGSSSVGDGNFRLVLDLLVSIARSFDISDIGSRIGAIQFTYDQRMEFNFNDHVLKDNALRALQKIPYMSGGTATGDAINFAVRSLFKP-RSSSNRKFLIIITDGQSYDDVRVPAMAAQREGITVYAVGVAWAPMEDLKAMASEPKESHVFFTREFTGLGQFQQPGICRDFTEFN- >NP_499400.2 Cuticlin-6 [Caenorhabditis elegans] --------------------------PIP-------------------------------------------------------------------------------------YDISLSITSFLSLILICSANPI--------DNGLVDSEECVTHK--AVEVILLLDASGSIGDDTFKKQLSFAMHLASRLNISEDGSHMALIQYAETPKLEFSLGQFNHPTQLEWAIQRIEYQSGATNTGQALRLTLEKGL---QGARPGIPKVAIVITDGQSQDDVSEPSQLLRDADVMVYAIGVTNLVPVRVFTVESFEQLDRALADS---LTWSM----CKTEFRPGTPEIICGPDRIGVKASTKDSRSIGLTVPFSASLNPKGIFVEVSIVFMFHSLFMTTDQTVKVQCFYMEADKHVTVPLSTTVFREQIYQMPQCAYTLRKGAPDGPIVRFATESVYHREVEGADKDTFGMLVHSCYVDNGYGDRVILDSNGCGLDAVLLSTPDYDTSLRLATKP--YHVFFQCQITGCEGITPPGTIDVFTDSVT >NP_001185764.1 cochlin precursor [Mus musculus] PSSRIPALCLGALLLLPRFARAEGAVPIPVTCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFAVTKGKSSTQEATGRAVSTAHPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAIAFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLRDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >NP_001102180.2 cochlin precursor [Rattus norvegicus] PSSWSPALCLGALLLLPRLARAEGAVPIPITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVIGTSGGPVRVYSLPGRENYSSVAANGIQSQTLSRWSASFAVTKGKSSTQEATGRAVSTANPPSGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGVGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYNTKENVLAVLANIRYMSGGTATGDAISFTVRNVFGPIRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_015142770.2 cochlin isoform X1 [Gallus gallus] AAMQFAPLLLGVFLLCGSACGSDSSASNAITCFTRGLDLRKETEDVLCPANCPLWQFYVFGDGIYASLSSVCGAAIHRGVITNAGGAVRVQTLPGQENYPAVHANGIQSQVLSRWASSFSVTRTNNLALEAVGRSVATARPATGKRPKKTLEKKAGNKDCKADIAFLIDGSYNIGQRRFNLQKNFVGKVAVMLGIGTEGPHVGVVQASEHPKIEFYLKNFTAAKEVLFAIKELGFRGGNSNTGKALKHAAQKFFSMENGARKGIPKIIVVFLDGWPSDDLEEAGIVAREFGVNVFIVSVAKPTTEELGMVQDIGFIDKAVCRNNGFFSYQMPSWFGTTKYVKPLVQKLCSHEQMLCSKTCYNSVNIGFLIDGSSSVGESNFRLMLEFISNVAKAFEISDIGSKIATVQFTYDQRTEFSFTDYTTKEKVLSAIRNIRYMSGGTATGDAISFTTRNVFGPVKDGANKNFLVILTDGQSYDDVRGPAVAAQKAGITVFSVGVAWAPLDDLKDMASEPRESHTFFTREFTGLEQMVPDGICKDFLDSKQ >XP_001171057.1 cochlin [Pan troglodytes] SAAWIPALGLGVLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_547762.4 cochlin [Canis lupus familiaris] SAAWIPVLGLGVLLLLPEPAGSDGAVPIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAVHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTARPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSPKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRRGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFIDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCSHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFHLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >NP_001071310.1 cochlin precursor [Bos taurus] WASWIPVLCLGVLLLPPEPVGSEGAVPIPITCSTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHRGVIGHSGGPVRIYSLPGRENYSSVVANGIQSQMLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVAFRGGNSNTGKALKHTAQKFFTADTGARKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLKFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNISYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_002718170.1 PREDICTED: cochlin [Oryctolagus cuniculus] SAAWLPALCLGVLLPLPEPAGSEGAVPLAITCTTRGLDIRKEKADVLCPAGCPLEEFSVFGNIVYAAVSSICGAAIHRGVIGTSGGPVRVYSLPGRENYSSADANGVRSQTLSRWSASFTVTKGKSSTQEATGRAVSTARPPAGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTTAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIITDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >KAF4017973.1 hypothetical protein G4228_009522 [Cervus hanglu yarkandensis] WASWIPVLCLGVLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_043345758.1 cochlin isoform X2 [Cervus canadensis] WASWIPVLCLGVLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPHKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >OWK08714.1 COCH [Cervus elaphus hippelaphus] QHSSIK----------------------SVKCPCKSLD--RTQLLFLC-----------------------C-----RGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_018086673.1 cochlin [Xenopus laevis] --MHFILYTLAVICVQLAATIAPGESSIPVTCSMRALDLKKELVQVLCPPGCAEQQLSVYGDGIYAAVSSICGAALHRGVLPKNGGMINVHRLPGQQDYPASSANGIQSQSLSRWTSSFSVSKAVSQGLEVSGKPVAS-QVASTKRLKKTPQKLTGNKDCKAEIAFVIDGSNNIGQRRFNLQKNFVARVSMLLGIGTDGPHVGVVQASEVPKTEFLLKNFTAPRDVQFAVKEISFRGGNSNTGKAIKHTAQNFFTTANGVRKGIPKVMVVFIDGWPSDNIEEAGIVAREFGINVFIVSVAPPAAEELGMVQDIAFIDKAVCRNSSYFSYHVPGWFGTAKHAKPLMQKLCSHEHLLCSKTCYNSVNIGFLIDGSSSVGDLNFRMMLDFMADVVRAFEVSDVGTKVGAVQFTYDQRLEFGLNDHSNKDDVLNALRNIRYMSGGTATGDAINFAVRNLFQPTKDGHNKNFLIIITDGQSYDDVRGPASSAHTSGVTVFSVGVAWAPMEDLKDMASEPKNSHTFFTREFPGLEQITSDGICRDYLDSHK >XP_030247842.1 cochlin [Sparus aurata] SRLSVLLPLTGLLFLMSSTLGSQSSVAFPVTCATRGAELTENSVLVLCPPDCTRGRVPVFGTGIYASVSTVCGAAVHRGLLGPSGGPVRVHKQKGQINYVSSYAHGIQSQALARWTASFSLSKPVNVPLELTSDTSTTALPAAAKKPVKKTSPTGGNKDCQMDIAMVIDSSNNIGQRRFNLQKNFVAKLAAMLRVGQTGPRVGLIQASDSPRTEFLLSNFTQPKELLFAIKELAYLGGDTNTGKAIMHTAESFFTQENGGRRGHPRVMMVLIDGWPSDDLEQAAMLARESGINVFLVSVAKPAPEELSMVRDKDFTRKAVCKDNGFFTYSIPSWFSTTKHVKPLSQRLCALDSLLCSKTCYNSVNIGFLIDGSSSVGDGNFQLVLDFLAGIARSFDISDVGARIGAVQFTYDQRLEFGLYDHSTKDDAINALKRISYMSGGTATGGAISYATQNLFR--RTGPGRNFLIVVTDGQSYDDVMRPAAAAQKQGITMFSVGVAWAPLDDLRAMASEPKDGHTFFTREFTGLADFVPPGICRDFTENN- >XP_024087351.1 cochlin [Pongo abelii] SAAWIPALGLGVLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEQPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAAIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITVFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_020955555.1 cochlin [Sus scrofa] SAAWIPVLCLGVLLLLPEPAGSEGAVPIPITCFTRGLDIRKEQADVLCPGGCLLEEFSVFGNIVYASVSSVCGAAVHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTARPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTAETGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRESPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_008972946.1 cochlin [Pan paniscus] SAAWIPALGLGVLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_011281477.1 cochlin [Felis catus] SAAWIPVLCLGVLLLLPEPAGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCSLEEFSVFGNIVYASVSSICGAAIHRGVISNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTARPSTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADAGVRRGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFTFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPVRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_027813031.1 cochlin [Ovis aries] WASWIPVLCLGVLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRREFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_004055095.1 cochlin isoform X1 [Gorilla gorilla gorilla] SAAWIPALGLGVLLLLPGPAGSEGAAPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVYGNIVYASVSSICGAAVHRGVISNSGGPVRVYSLPGRENYSSVDANGIQSQMLSRWSASFTVTKGKSSTQEATGQAVSTAHPPTGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTVDAGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVTFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGDSNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPIRESPNKNFLVIVTDGQSYDDVQGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_020569538.1 cochlin isoform X1 [Oryzias latipes] SLSSVL--LTGFLIFLSA-LESGSSGVDPVSCETRGSDLELDDVVVLCPPGCRRTRMSVFGTGPYAAVSSVCGAALHRGALGPSGGPVRVLKQRGQHSYVSSYANGIQSLGLSRWTSSFSLSESIHPPLEFIAETRTTSLPAGAKKALKKPSLAGGNKDCQMDVAVVMDSSRNIGQRRFNLQKNFVAKLAAMLRVGASGPRVGLIQASDSPKTEFVLSSYTQPKDLLFAIKELTFLGGDSNTGKAILHTAETFFTQENGMRRGHPRVMVVMIDGWPSDDVEQAAILARESGINVFLVSVAKPAAEELSMVADRDFMKKAVCKDNGFFSYSIPSWFSTTKHARSVTQRLCSLDSLLCSKTCYNSVNIGFLIDGSSSVGMDNFKMVLDFLAGIAQSFDISDIGSRVGAVQFTYDQRMEFGLFDHSTKEDTMNALRGISYMSGGTSTGSAISYATQNLFR--HPRRGHDFLVVVTDGQSYDDIRGPAMAAQRQGITIFSVGVAWAPLDDLRAMSSEPKDRHTLFTREFTGLLDFIPLSICQDFTEISE >XP_017921374.1 PREDICTED: cochlin [Capra hircus] WASWIPVLCLGVLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHVVYASVSSICGAAVHRGVIGNSGGPVRIYSLPGRENYSSVVANGIQSQTLSRWSTSFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLNNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRREFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_025058265.1 cochlin [Alligator sinensis] ---EISPPCTGLVGWRLSGLAISAFTFTAITCFTRGLDLRKEREDVLCPANCPLWQFHVYGNGVYASLSSICGAAIHSGVITTSGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSVALAAAGQPVSTARPSTGKRPKKPLEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNLVGKISVMLGIGAEGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKALKFTAQRFFSMDNGARKGIPKIIIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPTPEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGTTKYVKPLAQKLCTHEQMLCSKTCYNSINIAFLIDGSSSVGDSNFALMLEFISNVAKAFEISDIGSRIAAVQFTYDQRSEFIFSDYTTKEKVLTAIRNIRYMSGGTATGEAISFTNKNVFEPVKNGPNKNFLVILTDGQSYDDVRGPAAAAHKAGITVFSIGIAWAPLDDLKAMASEPRDTHTFFTREFTGLEQIVTDGICRDFLDSNQ >XP_019344348.1 PREDICTED: cochlin isoform X1 [Alligator mississippiensis] ---EISPPCTGLVGWRLSGLAISAFTLTAITCFTRGLDLRKEREDVLCPANCPLWQFHVYGNGVYASLSSICGAAIHSGVVTSTGGPVRVQSLPGEENYPAVYAKGIQSQALTRWASSFSLSRVKSVALAAAGQPVSTARPSTGKRPKKPLEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNLVGKISVMLGIGAEGPHVGVIQASEHPKIEFYLKNFTTAKDVLFAIKEIGFRGGNSNTGKALKFTAQRFFSMDNGARKGIPKIIIVFLDGWPSDDLEEAGIVAREFGINVFIVSVAKPTPEELGMVQDIGFVDKAVCRNNGFFSYQIPTWFGTTKYVKPLAQKLCTHEQMLCSKTCYNSINIAFLIDGSSSVGDSNFALMLEFISNVAKAFEISDIGSRIAAVQFTYDQRSEFIFSDYTTKEKVLTAIRNIRYMSGGTATGEAISFTNKNVFEPVKNGPNKNFLVILTDGQSYDDVRGPAAAAHKAGITVFSIGIAWAPLDDLKAMASEPRDTHTFFTREFTGLEQIVTDGICRDFLDSNQ >XP_015824907.1 PREDICTED: cochlin [Nothobranchius furzeri] SHLYFLLPLTGLLFFIPS-YSSRSNGLYPVSCETRGSDLKQDEVLVLCPPDCLQVRPSVFGSDVYAAISSICGAAVHRGILGPSGGPVRLQKQQGRRSYVSSYANGIHSQALHQWTASFHLSKTVDAPLELTNSARATAQPAATKKAMKSSVKQGENKDCQMDIAIIMDSSSNIGQRRFNLQKNFVTKLAAMLRVGPTGPHLGLIQTSDSPRTEFLLTNFTKPKELLFAIKELKYLGGDTNTGKAIMHAAEVFFTPGNGVRRGHPRVMMVLIDGWPSDDVERAAMLARESGINVFMVSVSKPAAEELSMVQDKDFLKKAVCKDNGFFSYSIPSWFSNNKHVRPLAQRLCSLDDLLCSKTCYNSVNIGFLIDGSSSVGWQNFQLVLDFLAGIAQSFDISDVGAHIGAVQFTYEQRVEFGLLDHSNKEDAVRALRRISYMNGGTATGSAISYATQNLFR--QAARGRNYLIVITDGQSYDDVQGPAMAAQRQGITIFSVGVAWAPMKELLDMASEPKDKHTFFTREFVNLSEFIQPGICQAFTENN- >XP_020732458.1 cochlin [Odocoileus virginianus texanus] WASWIPVLCLGVLLLPPEPVGSEGAVPIAITCFTRGLDIRKEKADVLCPGGCPLEEFSVFGHIVYASVSSICGAAVHRGVIGNSGGPVRVYSLPGRENYSSVVANGIQSQTLSRWSASFTVTKGKSGTQEATGQAVSTAHPATGKRLKKTPEKKTGNKDCKADIAFLIDGSFNIGQRRFNLQKNFVGKVALMLGIGTEGPHVGLVQASEHPKIEFYLKNFTSAKDVLFAIKEVGFRGGNSNTGKALKHTAQKFFTADTGVRKGIPKVVVVFIDGWPSDDIEEAGIVAREFGVNVFIVSVAKPIPEELGMVQDVAFVDKAVCRNNGFFSYHMPNWFGTTKYVKPLVQKLCTHEQMMCSKTCYNSVNIAFLIDGSSSVGESNFRLMLEFVSNIAKTFEISDIGAKIAAVQFTYDQRTEFSFTDYSTKENVLAVIRNIRYMSGGTATGDAISFTVRNVFGPMRDSPNKNFLVIVTDGQSYDDVRGPAAAAHDAGITIFSVGVAWAPLDDLKDMASKPKESHAFFTREFTGLEPIVSDGICRDFLESQQ >XP_040189331.1 cochlin [Rana temporaria] LSLHTIFVILGIIVQSASGDPGAGESPVPITCSMRGMDLKKESAQVLCPPGCNTQHVSVYGDGVYAGVSSVCGAAHHRGVISSNGGPLSLRRLPGQQNYAAVLANGVQSQPLTKWTSSFSVSKQKSRGMEVSGKPVST---STTRRQKKTPQKSTGNKDCKAEIAFLMDGSNNIGQRRFNLQKNFVAKVALMLGIGTDGPHVGVVQTSELPKTEFFLKNFTSAKDVVFAVKEINFKGGNSNIGKAIKHTAQTFFSISNGVRKGIPKVMVVFIDGWPSDNIEEAGIIAREYGINVFIVSVAPPSPEELGMVQDVAFIDKAVCKNNSFFSFHMPSWFGTAKYTKPLVQKLCTHEQLLCSKTCYNSVNIAFLIDGSSSIGDQNFRIMLDFITNIVRAFEVSDVGAKVAAVQFTYDQRLEFGLNDYSTKEDVLRATNNIPYMSGGTATGDAINFVLRSVFQPTKDGPNKNFLVLITDGQSYDDVRGPALAAHREGVTVYSVGVAWAPLDDLKDMASEPKNSHTFFSREFPGLEQIVPSGICRDYLDSQK
PhyML tree of selected proteins ((((XP_015142770_2_cochlin_isoform_X1__Gallus_gallus_:0.08753768,(XP_019344348_1_PREDICTED__cochlin_isoform_X1__Alligator_mississippiensis_:0.00807371,XP_025058265_1_cochlin__Alligator_sinensis_:0.00000001):0.16751924):0.08137648,((XP_020955555_1_cochlin__Sus_scrofa_:0.01203098,(XP_547762_4_cochlin__Canis_lupus_familiaris_:0.01391743,XP_011281477_1_cochlin__Felis_catus_:0.00710211):0.00477324):0.00000001,((KAF4017973_1_hypothetical_protein_G4228_009522__Cervus_hanglu_yarkandensis_:0.00000001,((XP_020732458_1_cochlin__Odocoileus_virginianus_texanus_:0.00199267,NP_001071310_1_cochlin_precursor__Bos_taurus_:0.01830054):0.00000001,(OWK08714_1_COCH__Cervus_elaphus_hippelaphus_:0.04262152,(XP_043345758_1_cochlin_isoform_X2__Cervus_canadensis_:0.00199244,(XP_017921374_1_PREDICTED__cochlin__Capra_hircus_:0.00199381,XP_027813031_1_cochlin__Ovis_aries_:0.00000001):0.00602903):0.00000001):0.00000001):0.00000001):0.01514402,((XP_024087351_1_cochlin__Pongo_abelii_:0.00596333,(XP_008972946_1_cochlin__Pan_paniscus_:0.00000001,(XP_001171057_1_cochlin__Pan_troglodytes_:0.00000001,(sp_O43405_COCH_HUMAN_Cochlin_OS_Homo_sapiens_OX_9606_GN_COCH_PE_1_SV_1:0.00000001,XP_004055095_1_cochlin_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.02255817,(XP_002718170_1_PREDICTED__cochlin__Oryctolagus_cuniculus_:0.03205114,(NP_001102180_2_cochlin_precursor__Rattus_norvegicus_:0.00881407,NP_001185764_1_cochlin_precursor__Mus_musculus_:0.01155776):0.03203474):0.00554671):0.01078486):0.003647):0.14101472):0.11184504,((XP_030247842_1_cochlin__Sparus_aurata_:0.08082837,(XP_020569538_1_cochlin_isoform_X1__Oryzias_latipes_:0.22558217,XP_015824907_1_PREDICTED__cochlin__Nothobranchius_furzeri_:0.23893681):0.0819601):0.27627812,(NP_499400_2_Cuticlin_6__Caenorhabditis_elegans_:6.13733027,tr_B3DFV8_B3DFV8_DANRE_Cochlin_OS_Danio_rerio_OX_7955_GN_coch_PE_1_SV_1:0.16084205):0.1591885):0.35859075):0.15456802,XP_040189331_1_cochlin__Rana_temporaria_:0.16301537,XP_018086673_1_cochlin__Xenopus_laevis_:0.21153226);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)