Click here to access PB0043 phyletic profile

PBID Uniprot Name Gene Alternative Organism Uniprot Description
PB0043 Q9UQP3 Tenascin-N TNN TN-W, TNW Homo_sapiens Expressed in most mammary tumors, may facilitate tumorigenesis by supporting the migratory behavior of breast cancer cells (PubMed:17909022).

DomainsGene Ontology
PF00041 (9_fn3)
PF00147 (Fibrinogen_C)
PF18720 (EGF_Tenascin)
GO:0003674 (enables) molecular_function
GO:0005178 (enables) integrin binding
GO:0042802 (enables) identical protein binding
GO:0002076 (involved in) osteoblast development
GO:0007160 (involved in) cell-matrix adhesion
GO:0007409 (involved in) axonogenesis
GO:0033689 (involved in) negative regulation of osteoblast proliferation
GO:0045668 (involved in) negative regulation of osteoblast differentiation
GO:0070593 (involved in) dendrite self-avoidance
GO:1905240 (involved in) negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation
GO:1990138 (involved in) neuron projection extension
GO:2001223 (involved in) negative regulation of neuron migration
GO:0005575 (is active in) cellular_component
GO:0005615 (is active in) extracellular space
GO:0062023 (is active in) collagen-containing extracellular matrix
GO:0005576 (located in) extracellular region
GO:0009986 (located in) cell surface
GO:0031012 (located in) extracellular matrix
GO:0043005 (located in) neuron projection
GO:0043025 (located in) neuronal cell body
GO:0097442 (located in) CA3 pyramidal cell dendrite
GO:1990026 (located in) hippocampal mossy fiber expansion

External Links Description
Intact Open source database system and analysis tools for molecular interaction data.
Protein Atlas An open access resource for human proteins
InterPro (new pfam) InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish)

Selected proteins from model organisms

Mafft alignment of selected proteins

BMGE Cleaned alignment of selected proteins

PhyML tree of selected proteins

BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)