PB0041

DATABASE

Click here to access PB0041 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0041	Q99645	Epiphycan	EPYC	DSPG3, PGLB, Pg-Lb, SLRR3B	Homo_sapiens	May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

Domains	Gene Ontology
PF13855 (LRR_8)	GO:0005539 (enables) glycosaminoglycan binding GO:0007565 (involved in) female pregnancy GO:0007605 (involved in) sensory perception of sound GO:0060348 (involved in) bone development GO:0061975 (involved in) articular cartilage development GO:0005576 (located in) extracellular region GO:0031012 (located in) extracellular matrix

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|Q99645|EPYC_HUMAN Epiphycan OS=Homo sapiens OX=9606 GN=EPYC PE=2 SV=3 MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIAT VMPSGNRELLTPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLL CTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLIS EIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLH HLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNP INLSKTPQAYMCLPRLPVGSLV >tr|B0S5X0|B0S5X0_DANRE Epiphycan OS=Danio rerio OX=7955 GN=epyc PE=1 SV=1 MVSLRLMWVLLVLCVAAASPPRYVRQTELHNYDDNNDVDLDQNVDGDNAYEDYYDGNESE IEITRVDPFEGIESSHSASLEEKEEEELPIKPQLIPPSSGASGTLMGPSAQGEEELRLIP TDILQISGDLSSGDAVPSGDLQDEKASSSGEPLGLGYSGASGGISGSVDSEDLSSGVSGL SGSGIILISGEEEELHPIPEFGPHEASGDSGESGIFGISGASGLPEGSGEPEVSGASGEP VSSGVPEVSGVSEASGIPDESGESGASGVPEGSAEPGISGVPEVSGESGVPEVSGETSGV PEMPAESGSSEEPEVSGESGTSGVPEVSGESGTSGVPEESGISGVPEVSGESGTSAVPEV YGESGTSGVPEVSGESETTGVPEISGESGISEVPDVSGQPETSEAHEMTVKPEIFEVPEE SRKPGPFDIFEESGVHEESGESGSPEETEVTEAPDFTTTVLIPDLDEEEEILLTTPTTPL EGTGGDIGSGIPDIDTDIYPDITGMSVCVLCTCLVGSVYCDDLKLDRVPPLSKDTTHFYS RYNKISRISKSDFANLNKLKKIDLTSNGISRIDDDAFFGLPSLEELILRENNIRQLPALP PSMTLIDVCHNHLGSTGIQREAFKDMPGLLYLYLTDNNIDHIPVPLPESLRSLHLQNNNI QMIHEDTFCNPHDLNYIRNALEDVRLDGNPINLSRTPQAYICLPRIPIGNLF
Selected proteins from model organisms >NP_004941.2 epiphycan precursor [Homo sapiens] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDKVEIEIATVMPSGNRELL TPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCN VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >XP_043303229.1 epiphycan [Cervus canadensis] MKALASLIVGLVILGAAVTAPTLESINYDSENYDATLEDLDHLYSYENIPVGRAEIEIATVMPSGNRELLTPPPQPEEPE EEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKN DFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHH LYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSL V >KAB0378011.1 hypothetical protein FD755_009589 [Muntiacus reevesi] MQEEETKNNLKEKPSLTRFSNFIKVPCIVKALKKVNFNIPILLIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLI DGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRID LTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIP LPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >KAB0364801.1 hypothetical protein FD754_008957 [Muntiacus muntjak] MLTTSCLEQISHPKFQGQQEIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDFP TCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLTRIDLTSNLISEIDEDAFRKLPQLREL VLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHED TFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_018109796.1 epiphycan S homeolog isoform X1 [Xenopus laevis] MKTFVNLFLGLFILQTALAAPTIETINYDTDTYEDVLDSLYDYDENPIVDQGKIEIGTVLPVVNRPILSPEQVPEETEEA EESTPKLIDGSSPQGPLTPGVQGPDTSGAISPTCILCACLITTVYCDDHNLDTIPPLPKETTHVYLRFNRISKISKHDFN HLTKLKKIDLTSNIISEIDEDAFRNLPQLSELILRDNNIRQLPELPNTMNFIDVSNNRLGSKGIKQEAFKDMTDLHILYL TNNHLNHIPIPLPDNLQSLHLQDNNIQEMHEDTFCKMKDWTYARRTLEDIRLDGNPINLSRTPQAFMCLPRIPIGRLV >KAF4010142.1 hypothetical protein G4228_001458 [Cervus hanglu yarkandensis] MATTICFIIWVLFVTDTVWTRSVRQVYEASDPEDWTMHDFDCPRECFCPPSFPTALYCENRGLKEIPAIPSRIWYLYLEN NLIETIPEKPFENATQLRWINLNKNKITNYGIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQG TFSNLENLTLLDLQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENYFNVIPKVA FLRLNHNKLSDAGLPSSGFNVSSILDLQLSHNQLTKVPKISAHLQHLHLDHNKIRKSINYDSENYDATLEDLDHLYSYEN IPVGRAEIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDDLRRIDLTSNLISEI DEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRA LHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_030296407.1 epiphycan isoform X3 [Sparus aurata] MRMLVRLVLGLLVLKAVVAGPRFSRQVDLDSYDSANYDVDLDNLNSENQDIYDYDDGLTIDDPQIEIGTLAPPDYNYPVP EASLEEQEQEEEEEEEEMPLKPQLIPQGSGGSGVLMGPDTQKGMPTCLLCTCLGGSVYCDDLKLDSVPPLPKDTTHFYAR YNRITKINKSDFAFLNKLKRIDLTANEITSVDDRAFMALPELEELVIRENHISQLPALPETMTLIDASHNNIGTKGIHNE AFKDMTSLLYLYLTDNHVDYIPVPLPDSLRSLHLQRNNIQMMHEDTFCNLKDFNYIRNALEDIRLDGNPINLSRTPQAYI CLPRIPIGDLI >OWK08495.1 OPTC [Cervus elaphus hippelaphus] MKLLALLSLLILMLQEAGTASLSKEEREEDQPYGEGDSYAVLHLGDYVLSLDNYDEVIDPSNYDKLTDYGDQLPQVKGTG LASLTRTRFTQSTEVARTLPSNPTMGRPPTLGLLAAPTDLGLPTCLICVCLGSSVYCDDTELENIPPLPQTTAYLYARFN RISHIRAGDFKGLTKLKRIDLSGNSISSIDDKALRLLPALRDLILPENKLTALPMLPTSIEVLDVRMNRLQSSGIQPEAF RALEKLQFLYLADNLLDAIPRSLPLSLRSLHLQVSGCSGNKGVERHRRWRSDCREPPSAVVGLRH >XP_038060753.1 leucine-rich repeat transmembrane neuronal protein 1-like [Patiria miniata] MSNRSFLRLPVVCILSQLYFYFILCRPTLACPVRCDCEVKGEVNCTDVNLEGLPSSDLPSNIHFLYLGSNFISSVNEDDF QDLSDLKQLHLARNRISQLQTSAFRPLQILQVLDLRFNRINQIPDDAFTGLVSLIELNLGGNGIGSISRDAFAEMQSLEV LNLSDSNLRVSGLPAGLFQGARNLKWLDIEGSELRRVPNGMFEHLSNLTYLDLSWNRGIDLDMPSLFSSLRSMQTLIMEG CELSFLEPWSFAGLTSMIDLQLSFNALQEALPLALFEKTPHLRRIRLSNNSLTHLHERLFDSIDNLQYLEVLNNPWHCGC GLLGLRARWSYQLPVFFQRGLVCQSPEPFHGRDLWSLPLHELYDFCASGIKEMSTITLRGKGEGLQSLDCPVHAGTNIAW FTPNNEYITTHNVAIGNDPNQQNLSHRLLANGTLLVDSIQLGTYVCTVTLSDGSYIVGGVQVDIVPLKSPGPPQINNQSN LHFLLAFAVLIILGIVALAAWVAYRIRRRYSRRRYDSLSKEHALIEMRPPAQIHPEQTDYDYDYAYAHPRARLDLTSHES PYAVGGLCEERRLNVGRSLVPRCRPISRSMHERGPRYYNDCVRAALPRTSHTISTGEVNGYITPSQITAYTMSVRSWKSQ GQDLTSRVGKFQNPNCNCVSLSPPNISRPDSSDHRYLEIV >NP_001366385.1 epiphycan precursor [Mus musculus] MGMLARVALGLIIIDAVLAAPTTELFNYDSEVYDAILEDTGTFYNYEHIPDNHVENEKVSERLSGNRELL TPGPQLGDNQDEDKDEESTPRLIDGSSPQEPEFPGLLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKKTTYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPHLQELVLRDNKIKQLPELP NTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPESLRALHLQNNDILEMHEDTFCN VKNLTYVRKALEDIRLDGNPINLSRTPQAYMCLPRLPIGSFI >NP_776732.1 epiphycan precursor [Bos taurus] MKALARLIVGLLILDAAVTAPTLESINYNSETYDATLEDLDHLYNYENIPMGRAEIEIATVMPSGNRELL TPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDDHELDAIPPL PKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPT TLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNIMEMHEDTFCNV KNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >NP_001101558.1 epiphycan [Rattus norvegicus] MKHTRIHIHWSEVNTKDSVCSVTLCHFVKSEPKKSQKMRMAARIVLVLIIIDATLAAPTTELFNYDSEVY DAILEDTGTFYNYEHIPDNQVETEKVAERLSGNRELLTPGPQLGDSQDEDKDEESTPRLIDGSSPQEPEF PGLLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLPKKTTYFYSRFNRIKKINKNDFASLSDLKRID LTSNLISEIDEDAFRNLPRLQELVLRDNKIKQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLY ITDNSLDHIPLPLPENLQALHLQNNDILEMHEDTFCNVKNLTYVRKALEDIRLDGNPINLSKTPQAYMCL PRLPIGSFI >XP_025003921.1 epiphycan isoform X1 [Gallus gallus] MLIRRQQGKREKEKSRMKTFVNIFLGFFIFESVGAVPITDTVTYDSEFYDVSLGELPHPFVSAENDQSDQ VETEIGTAIPSIIQESYSSAPLTEEPEEEASTPKLIDGSSAQGSGVLVPQTQDGLPTCLLCTCLGTTVYC DDRELDAVPPLPKNTMYFYSRYNRIRKINKNDFANLNNLKRIDLTANLISEIHEDAFRRLPQLLELVLRD NRIRQLPELPSTLTLIDISNNRLGRKGIRNEAFKDLHELQHLYITDNNLDHVPLPLPESLQALHLQNNNI QEMHEDTFCKMRDFSYVRRALEDIRLDGNPINLSKTPYAYMCLPRLPVGNLI >XP_001134960.1 epiphycan [Pan troglodytes] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDQVEIEIATVMPSGNRELL TPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLQALHLQNNNILEMHEDTFCN VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >NP_001017903.3 epiphycan isoform 1 precursor [Danio rerio] MVSLRLMWVLLVLCVAAASPPRYVRQTELHNYDDNNDVDLDQNVDGDNAYEDYYDGNESEIEITRVDPFE GIESSHSASLEEKEEEELPIKPQLIPPSSGASGTLMGPSAQGEEELRLIPTDILQISGDLSSGDAVPSGD LQDEKASSSGEPLGLGYSGASGGISGSVDSEDLSSGVSGLSGSGIILISGEEEELHPIPEFGPHEASGDS GESGIFGISGASGLPEGSGEPEVSGASGEPVSSGVPEVSGVSEASGIPDESGESGASGVPEGSAEPGISG VPEVSGESGVPEVSGETSGVPEMPAESGSSEEPEVSGESGTSGVPEVSGESGTSGVPEESGISGVPEVSG ESGTSAVPEVYGESGTSGVPEVSGESETTGVPEISGESGISEVPDVSGQPETSEAHEMTVKPEIFEVPEE SRKPGPFDIFEESGVHEESGESGSPEETEVTEAPDFTTTVLIPDLDEEEEILLTTPTTPLEGTGGDIGSG IPDIDTDIYPDITGMSVCVLCTCLVGSVYCDDLKLDRVPPLSKDTTHFYSRYNKISRISKSDFANLNKLK KIDLTSNGISRIDDDAFFGLPSLEELILRENNIRQLPALPPSMTLIDVCHNHLGSTGIQREAFKDMPGLL YLYLTDNNIDHIPVPLPESLRSLHLQNNNIQMIHEDTFCNPHDLNYIRNALEDVRLDGNPINLSRTPQAY ICLPRIPIGNLF >XP_020948689.1 epiphycan isoform X2 [Sus scrofa] MKTLARLILGFVILDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPMGPAEIDVATVMPSGNRELL TPPPQPEEAEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLP KTTAYFYSRFNRIKKINKSDFANLNDLRRIDLTSNLISEIDEDAFRKLPQLQELVLRDNKIRQLPELPTT LTFIDISNNRLGRKGIKQEAFKDMYDLRHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVK NLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >XP_002711429.1 PREDICTED: epiphycan [Oryctolagus cuniculus] MNILASLILGLVFFDAAVTAPTPDSINYDSETYGATLEDFDNLYNYENIPIEQAESEIATMMPSGNSELL TLPPKPEETQEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPL PKNTAYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPT TLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNV KNVTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_024112745.1 epiphycan [Pongo abelii] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDQVEIEIATVMPSGNRELL TPPPQPEEAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKNTAYFYARFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCN VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >XP_010707300.2 epiphycan [Meleagris gallopavo] MKRTTVFLRLNFHGLLAIIILVTFCSFSSLSGKKKKDRMKTFVNIFLGFFIFEYVGAVPITDPVTYDSEF YDVSLGELPHPFVYAENEQSDQLETEIGTAIPSIIQESYSSAPLTEEPEEEASTPKLIDGSSAQGSGVLV PQTQDGLPTCLLCTCLGTTVYCDDHELDAVPPLPKKTMYFYSRYNRIRKINKNDFANLNNLKRIDLTANL ISEIHEDAFRRLPQLQELVLRDNRIRQLPKLPSTLTFIDVSKNRLGRKGIRNEAFKDLHELQHLYITDNN LDHVPLPLPESLQALHLQNNNIQEMHEDTFCKMRDFTYVRRALEDIRLDGNPINLSKTPYAYMCLPRLPV GNLI >XP_013975233.1 epiphycan [Canis lupus familiaris] MKMLARLILGLVIFDAAVTAPTLEPINYDSETYDATLEDLDNLYNYENIPIGQAEIEIATVMPSGNRELL TPPPQPEEAEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLP KNTAYFYSRFNRIKKINKNDFASLDDLRRIDLTSNLISEIDEDAFRKLPHLRELVLRDNKIRQLPELPNT LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVK NLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_003823452.1 epiphycan [Pan paniscus] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDQVEIEIATVMPSGNRELL TPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLQALHLQNNNILEMHEDTFCN VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >XP_003989156.1 epiphycan [Felis catus] MKTLARLILGLVIFDAAVTAPTLDPINYDSETYDATLDDLDNLYNYENIPIGQAEIEIATVMPSGNRELL TPPPQPEEAEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPPLP KNTAYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPNT LTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVK NLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_014950074.1 epiphycan [Ovis aries] MKALARLIVGLVLLDAAVTAPTLESINYDSETYDATLEDLDHLYNYENIPVGRAEIEIATVMPSGNRELL TPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDDHELDAIPPL PKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPT TLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNV KNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLI >XP_018893579.1 epiphycan [Gorilla gorilla gorilla] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLEDLDNLYNYENIPVDQVEIEIATVMPSGNRELL TPPPQPEKAQEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEDFPTCLLCTCISTTVYCDDHELDAIPP LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELP TTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCN VKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPVGSLV >XP_004083110.1 aggrecan core protein [Oryzias latipes] MRMFVRLVLGLFVLKAAVASPRFSRQANLDIYDDANYDEELNNVESEDTYDYEDGLTIDEPEIEIETMAL PDYTFPEEEKPEEGEEEELTLRPQPIPQGSGGSGVLMGPETQKEVELRQEPVDILHASGDLGGSGSGSGT SGASGASGSGESGDLLISGDIILISGASETLISSEGSGEFLISEKTDFTIPWHTSGSGFESSPSGASGDL TSGHSGISIEIPFGSGESGESGESGDLSGISPDPSISGASGSSGVSGDPAESGDLGITLISGDEKPFVIS KHEPQEASVASGEISGVSSADTEISGTSGVSGVSTSGDDEEPVTVIIETKEEERVLSTTPETPQEGATSI EETDSSGLPEPFEPKEPDEPKIDISGMPTCLLCTCLGTSVYCDDLKLDSVPPLPKETTHFYARYNKITKI NKSDFAFMNKLKRVDLTANEITAIDGTAFIGLPELEELVVRQNHLTQLPALPETMTLIDASHNSIGSKGI HKEAFKDMTGLLFLYLTDNNIDYIPVPLPESLRSLHLQRNNIQMMHEDTFCNLNDFNYIRNALEDIRLDG NPINLSKTPQAYVCLPRIPIGNLI >XP_005508374.1 epiphycan [Columba livia] MQTFANIFLGFFIFESVGAAPISDTVIYDSEFYDIPLGELPHPFVYDENEPSDQLETEIGTALPSVIQES YSSAPLTEEHEEEASTPKLIDGSSAQGSGVLGPQTQDGLPTCILCTCIGTTVYCDDHELDAVPPLPKKTM YFYSRYNRIRKINRNDFANLNKLKRIDLTANFISEIHEDAFRRLPQLEELVLRDNRIRQLPELPSTLTLI DVSKNRLGRKGIRNEAFKDLHELQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDFSY VRRALEDIRLDGNPINLSRTPYAYMCLPRLPVGNLI >XP_005679865.2 PREDICTED: epiphycan [Capra hircus] MKALARLIVGLVLLDAAVTAPTLESINYDSETYDATLEDLDHLYNYENIPVGRAEMEIATVMPSGNRELL TPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDDRELDAIPPL PKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRGNKIRQLPELPT TLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNV KNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_006029354.1 epiphycan [Alligator sinensis] MKTLANIFLGFFIFEGIVAAPTIDTLTYDSDLYGIILGESDNLFDHIENEQSAQAETEVGTILPFVTQDS YSSAPLTEEPEEEASTPKLIDGSSPLGSGVLGPQTHDGLPTCLLCTCLGTTVYCDDHELNAIPPLPKKTT YFYSRYNRIKKINRNDFANLNNLKRIDLTENFISEIDEDAFRKLPQLQELVLRNNKIRQLPELPATLTFI DISNNRLGRKGIRTEAFKDMIDLQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDVTY VRRALEDIRLDGNPINLSKTPYAYMCLPRLPIGSLI >XP_019336346.1 PREDICTED: epiphycan [Alligator mississippiensis] MKTLANIFLGFFIFEGIVAAPTIDTLTYDSDLYGIILGESDNLFDHIENEQSAQAETEVGTILPFVTQDS YSSAPLTEEPEEEASTPKLIDGSSPLGSGVLGPQTHDGLPTCLLCTCLGTTVYCDDHELNAIPPLPKKTT YFYSRYNRIKKINRNDFANLNNLKRIDLTENFISEIDEDAFRKLPQLQELVLRNNKIRQLPELPATLTFI DISNNRLGRKGIRTEAFKDMIDLQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDVTY VRRALEDIRLDGNPINLSKTPYAYMCLPRLPIGSLI >XP_015815457.1 PREDICTED: dentin sialophosphoprotein-like [Nothobranchius furzeri] MRMLVRLVLGLFVLKAAIASPRFSRQVDLDTYDLANYDEEEDNFDLDNGESYDYDEELTTDESETETETP NELDYNHPPEDLEEEKPEEEEDVQQEKGGEEENQEEKEEEDNHEEEYNQGEENEEEELPLTPQLIPQGSG GSGVLMGPDTQKEVELRRVPVDTLHVSGDFGGSAGSGASGASGASGASGASGSGGSGDILVSGASGESGE IIMMSGASEELFSSGGPEELLSGDILISGDLSGSGVTSGSGVSGFSGDIPSGESEFVTELPVGSGGSGDP SGSGFSGDILISGASGISGASGISGASGISGVSGDSFESGQSGITFITEEEERPLVPEIIPQEASGGSGE ISGVSGTSGASGDIGVSGGLEVSGTSGTSGVSASGDIEVPEVNLLPEPEEEEELLPTTPEPSQEVQTSIE ETMTSGDPEQPEEEVVDAQGMPVCLLCTCLGGSVYCDDLKLDSVPPLPKDTTHFYARYNKITKINKSDFA NMNKLKRIDLTANEITAIDDKAFMGLPALEQLIIRENHVSQLPALPETMTLIDGSHNNIGSRGIHKEAFK DMTSLQFLYLTDNNIDYIPVPLPDSLRSIHLQRNNIQMMHEDTFCNLNDFNYIRNALEDIRLDGNPINLS KTPQAYICLPRIPVGNLV >XP_020750509.1 epiphycan isoform X1 [Odocoileus virginianus texanus] MPSGNRELLTPPPQPEEAEEEEEEESTPRLIYGSSPQEPEFTGVLGPQTNEDFPTCLLCTCISTTVYCDD HELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNK IRQLPELPTTLRFIDISNNRLGRKGIKQEAFKALHLERLQDMYDLHHLYLTDNNLDHIPLPLPENLRALH LQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQAYMCLPRLPIGSLV >XP_040200080.1 epiphycan [Rana temporaria] MKTLANIFLGLLIIKAVVSAPPTDSVNYDTAAYEVDLLYNLYDYDENTNIDQGEIEIGTVLPVVNRPILS PEPVQEEIEEEEESTPKLIDGSSPQGPLSPGVPEASGGVSTCILCGCIRTTVYCDDHNLDAVPPLPKDTT HVYLRFNRISKINKNDFSYLSKLQKIDLTSNIISDIDEDAFRSLSQLDELILLDNNIRQLPELPHSVSFL DVSKNRLGRKGIKQEAFKDLNDLRLLYLNNNNLDHIPIPLPDSLQALHLQDNNIQEMHEDTFCNMKDFTY ARRSLEDIRLDGNPINLSKTPQAFMCLPRIPVGRLV
Mafft alignment of selected proteins >NP_004941.2 epiphycan precursor [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLAGLVL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPVDKVEIEIATVMPSGNREL LTPPPQPEKAQEEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >XP_043303229.1 epiphycan [Cervus canadensis] ------------------------------------------------------------ ------------------------------------------------------------ -------MKALASLIV--------------------------------------GLVILG ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSENYDATLE----DLD----HLYSY-E--NIPVGRAEIEIATVMPSGNREL LTPPPQPEEP-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >KAB0378011.1 hypothetical protein FD755_009589 [Muntiacus reevesi] ------------------------------------------------------------ ----------------------------------------------------------MQ EEETKNNLKEKPSLTR--------------------------------------FSNFIK ------------------------------VPCIVK------------------------ ------------------------------------------------------------ -ALKKVNF------------------------------NIPI--LLIEIATVMPSGNREL LTPPPQPEEP-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >KAB0364801.1 hypothetical protein FD754_008957 [Muntiacus muntjak] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------MLTTS------------------------ ------------------------------------------------------------ -CLEQISHPKFQ------------------------------GQQEIEIATVMPSGNREL LTPPPQPEEP-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLTRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_018109796.1 epiphycan S homeolog isoform X1 [Xenopus laevis] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTFVNLFL--------------------------------------GLFILQ ------------------------------TALAAP------------------------ ------------------------------------------------------------ -TIETINYDTDTYEDVLD-----------SLYDYDE--NPIVDQGKIEIGTVLPVVNRPI LSPEQVPE---ETEEA-------------------------------EESTPKLIDGSSP QGPLTPGVQ-GPDTSG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------AISPT CILCAC-LITTVYCDDHNLDTIPP--LPKETTHVYLRFNRISKISKHDFNHLTKLKKIDL TSNIISEIDEDAFRNLPQLSELILRDNNIRQLP--ELPNTMNFIDVSNNRLGSKGIKQEA FK--------DMTDLHILYLTNNHLNHIPIPL-----PDNLQSLHLQ-----DNNIQEMH EDTFCKMKDWTYA------------------RRTLEDIRLDGNPINL------------- ------------------SRTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AFMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------IGR---------------------------- LV >KAF4010142.1 hypothetical protein G4228_001458 [Cervus hanglu yarkandensis] MATTICFIIW--------VLFVTDTVWTRSVRQVYEASDPEDWTMHDFDCPRECFCPPSF PTALYCENRGLKEIPAIPSRIWYLYLENNLIETIPEKPFENATQLRWINLNKNKITNYGI EKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLD LQHNKLLDNAFQRDTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLFLDNNSIEGIPENY FNVIPKVAFLRLNHNKLSDAGLPSSGFNVSSILDLQLSHNQLTKVPKISAHLQHLHLDHN KIRKSINYDSENYDATLE----DLD----HLYSY-E--NIPVGRAEIEIATVMPSGNREL LTPPPQPEEP-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------DDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_030296407.1 epiphycan isoform X3 [Sparus aurata] ------------------------------------------------------------ ------------------------------------------------------------ -------MRMLVRLVL--------------------------------------GLLVLK ------------------------------AVVAGP-RF--------------------- -----------------------------------------------------------S RQVDLDSYDSANYDVDLD----NLNSENQDIYDYDD--GLTIDDPQIEIGTLAPPDYNYP VPEASLEEQE-QEEEE-------------------------------EEEEMPLKPQLIP QGSGGSGVLMGPDTQK-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GM-PT CLLCTC-LGGSVYCDDLKLDSVPP--LPKDTTHFYARYNRITKINKSDFAFLNKLKRIDL TANEITSVDDRAFMALPELEELVIRENHISQLP--ALPETMTLIDASHNNIGTKGIHNEA FK--------DMTSLLYLYLTDNHVDYIPVPL-----PDSLRSLHLQ-----RNNIQMMH EDTFCNLKDFNYI------------------RNALEDIRLDGNPINL------------- ------------------SRTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYIC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------IGD---------------------------- LI >OWK08495.1 OPTC [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ -------MKLLALLSL--------------------------------------LILMLQ ------------------------------EAGTAS------------------------ ------------------------------------------------------------ -LSKEEREEDQPYGEGDSYAVLHLGDYVLSLDNYDEVIDPSNYDKLTDYGDQLPQVKGTG LASLTRT----RFTQS-------------------------------TEVARTLPSNPTM GRPPTLGLL-AAPTDL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CLICVC-LGSSVYCDDTELENIPP--LPQTTAYLYARFNRISHIRAGDFKGLTKLKRIDL SGNSISSIDDKALRLLPALRDLILPENKLTALP--MLPTSIEVLDVRMNRLQSSGIQPEA FR--------ALEKLQFLYLADNLLDAIPRSL-----PLSLRSLHLQVSGCSGNKGVERH -------------------------------RRWRSDCR--------------------- -------------------EPPS------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AVVG---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LRH---------- ------------------------------------------------------------ -- >XP_038060753.1 leucine-rich repeat transmembrane neuronal protein 1-like [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ -------MSNRSFLRL--------P-----------------------------VVCILS ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------QLYFY-------------------------- ----------------------------------------F------------------- -------ILCRP------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------TL-AC PVRCDCEVKGEVNCTDVNLEGLPSSDLPSNIHFLYLGSNFISSVNEDDFQDLSDLKQLHL ARNRISQLQTSAFRPLQILQVLDLRFNRINQIPDDAFTGLVSLIELNLGGNGIGSISRDA FA--------EMQSLEVLNLSDSNLRVSGLPAGLFQGARNLKWLDIE-----GSELRRVP NGMFEHLSNLTYLDLSWNRGIDLDMPSLFSSLRSMQTLIMEGCELSFLEPWSFAGLTSMI DLQLSFNALQEALPLALFEKTPHLRRIRLSNNSLTHLHERLFDSIDNLQYLEVLNNPWHC GCGLLGLRARWSYQLPVFFQRGLVCQSPEPFHGRDLWSLPLHELYDFCASGIKEMSTITL RGKGEGLQSLDCPVHAGTNIAWFTPNNEYITTHNVAIGNDPNQQNLSHRLLANGTLLVDS IQLGTYVCTVTLSDGSYIVGGVQVDIVPLKSPGPPQINNQSNLHFLLAFAVLIILGIVAL AAWVAYRIRRRYSRRRYDSLSKEHALIEMRPPAQIHPEQTDYDYDYAYAHPRARLDLTSH ESPYAVGGLCEERRLNVGRSLVPRCRPISRSMHERGPRYYNDCVRAALPRTSHTISTGEV NGYITPSQITAYTMSVRSWKSQGQDLTSRVGKFQNPNCNCVSLSPPNISRPDSSDHRYLE IV >NP_001366385.1 epiphycan precursor [Mus musculus] ------------------------------------------------------------ ------------------------------------------------------------ -------MGMLARVAL--------------------------------------GLIIID ------------------------------AVLAAP------------------------ ------------------------------------------------------------ -TTELFNYDSEVYDAILE----DTG----TFYNY-E--HIPDNHVENEKVSERLSGNREL LTPGPQLGDNQDEDKD-------------------------------EESTPRLIDGSSP QEPEFPGLL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKKTTYFYSRFNRIKKINKNDFASLNDLKRIDL TSNLISEIDEDAFRKLPHLQELVLRDNKIKQLP--ELPNTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYITDNSLDHIPLPL-----PESLRALHLQ-----NNDILEMH EDTFCNVKNLTYV------------------RKALEDIRLDGNPINL------------- ------------------SRTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- FI >NP_776732.1 epiphycan precursor [Bos taurus] ------------------------------------------------------------ ------------------------------------------------------------ -------MKALARLIV--------------------------------------GLLILD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYNSETYDATLE----DLD----HLYNY-E--NIPMGRAEIEIATVMPSGNREL LTPPPQPEEA-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNIMEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >NP_001101558.1 epiphycan [Rattus norvegicus] MKHTRIHIHWSEVNTKDSVCSVT-------------------------------LC--HF ---------------------------------------------------------VKS EPKKSQKMRMAARIVL--------------------------------------VLIIID ------------------------------ATLAAP------------------------ ------------------------------------------------------------ -TTELFNYDSEVYDAILE----DTG----TFYNY-E--HIPDNQVETEKVAERLSGNREL LTPGPQLGDSQDEDKD-------------------------------EESTPRLIDGSSP QEPEFPGLL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKKTTYFYSRFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRNLPRLQELVLRDNKIKQLP--ELPNTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYITDNSLDHIPLPL-----PENLQALHLQ-----NNDILEMH EDTFCNVKNLTYV------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- FI >XP_025003921.1 epiphycan isoform X1 [Gallus gallus] M-----LIRR-------------------------------------------------- --------------------------------------------------------QQGK REKEKSRMKTFVNIFL--------------------------------------GFFIFE ------------------------------SVGAVP------------------------ ------------------------------------------------------------ -ITDTVTYDSEFYDVSLG----ELP----HPFVSAE--NDQSDQVETEIGTAIPSIIQES YSSAPLT----EEPEE-------------------------------EASTPKLIDGSSA QG---SGVL-VPQTQD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CLLCTC-LGTTVYCDDRELDAVPP--LPKNTMYFYSRYNRIRKINKNDFANLNNLKRIDL TANLISEIHEDAFRRLPQLLELVLRDNRIRQLP--ELPSTLTLIDISNNRLGRKGIRNEA FK--------DLHELQHLYITDNNLDHVPLPL-----PESLQALHLQ-----NNNIQEMH EDTFCKMRDFSYV------------------RRALEDIRLDGNPINL------------- ------------------SKTPY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGN---------------------------- LI >XP_001134960.1 epiphycan [Pan troglodytes] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLAGLVL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPVDQVEIEIATVMPSGNREL LTPPPQPEKAQEEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLQALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >NP_001017903.3 epiphycan isoform 1 precursor [Danio rerio] ------------------------------------------------------------ ------------------------------------------------------------ -------MVSLRLMWV---------------------------------------LLVLC ------------------------------VAAASPPRY--------------------- -----------------------------------------------------------V RQTELHNYDDNN-DVDLDQ---NVDGDN-AYEDYYD-----GNESEIEITRVDPFEGIES SHSA-------SLEEK-------------------------------EEEELPIKPQLIP PSSGASGTLMGPSAQGEEELRLIPTDILQISGDLSSGDAVPSGDLQDEKASSSGEPLGLG YSGASGGISGSVDSEDLSSGVSGLSGSGIILISGEEEELHPIPEFGPHEASGDSGESGIF GISGASGLPEGSGEPEVSGASGEPVSSGVPEVSGVSEASGIPDESGESGASGVPEGSAEP GISGVPEVSGESGVPEVSGETSGVPEMPAESGSSEEPEVSGESGTSGVPEVSGESGTSGV PEESGISGVPEVSGESGTSAVPEVYGESGTSGVPEVSGESETTGVPEISGESGISEVPDV SGQPETSEAHEMTVKPEIFEVPEESRKPGPFDIFEESGVHEESGESGSPEETEVTEAPDF TTTVLIPDLDEEEEILLTTPTTPLEGTGG---DIGSG-----IPDIDTDIYPDITGM-SV CVLCTC-LVGSVYCDDLKLDRVPP--LSKDTTHFYSRYNKISRISKSDFANLNKLKKIDL TSNGISRIDDDAFFGLPSLEELILRENNIRQLP--ALPPSMTLIDVCHNHLGSTGIQREA FK--------DMPGLLYLYLTDNNIDHIPVPL-----PESLRSLHLQ-----NNNIQMIH EDTFCNPHDLNYI------------------RNALEDVRLDGNPINL------------- ------------------SRTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYIC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------IGN---------------------------- LF >XP_020948689.1 epiphycan isoform X2 [Sus scrofa] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLARLIL--------------------------------------GFVILD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPMGPAEIDVATVMPSGNREL LTPPPQPEEA--EEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKTTAYFYSRFNRIKKINKSDFANLNDLRRIDL TSNLISEIDEDAFRKLPQLQELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLRHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >XP_002711429.1 PREDICTED: epiphycan [Oryctolagus cuniculus] ------------------------------------------------------------ ------------------------------------------------------------ -------MNILASLIL--------------------------------------GLVFFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TPDSINYDSETYGATLE----DFD----NLYNY-E--NIPIEQAESEIATMMPSGNSEL LTLPPKPEET-QEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNVTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_024112745.1 epiphycan [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLAGLVL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPVDQVEIEIATVMPSGNREL LTPPPQPEEAQEEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYARFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >XP_010707300.2 epiphycan [Meleagris gallopavo] MKRTTVFLRLNFHGLLAIIILVT-------------------------------FC--SF --------------------------------------------------------SSLS GKKKKDRMKTFVNIFL--------------------------------------GFFIFE ------------------------------YVGAVP------------------------ ------------------------------------------------------------ -ITDPVTYDSEFYDVSLG----ELP----HPFVYAE--NEQSDQLETEIGTAIPSIIQES YSSAPLT----EEPEE-------------------------------EASTPKLIDGSSA QG---SGVL-VPQTQD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CLLCTC-LGTTVYCDDHELDAVPP--LPKKTMYFYSRYNRIRKINKNDFANLNNLKRIDL TANLISEIHEDAFRRLPQLQELVLRDNRIRQLP--KLPSTLTFIDVSKNRLGRKGIRNEA FK--------DLHELQHLYITDNNLDHVPLPL-----PESLQALHLQ-----NNNIQEMH EDTFCKMRDFTYV------------------RRALEDIRLDGNPINL------------- ------------------SKTPY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGN---------------------------- LI >XP_013975233.1 epiphycan [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ -------MKMLARLIL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLEPINYDSETYDATLE----DLD----NLYNY-E--NIPIGQAEIEIATVMPSGNREL LTPPPQPEEA--EEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLDDLRRIDL TSNLISEIDEDAFRKLPHLRELVLRDNKIRQLP--ELPNTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_003823452.1 epiphycan [Pan paniscus] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLAGLVL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPVDQVEIEIATVMPSGNREL LTPPPQPEKAQEEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLQALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >XP_003989156.1 epiphycan [Felis catus] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLARLIL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLDPINYDSETYDATLD----DLD----NLYNY-E--NIPIGQAEIEIATVMPSGNREL LTPPPQPEEA--EEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPNTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_014950074.1 epiphycan [Ovis aries] ------------------------------------------------------------ ------------------------------------------------------------ -------MKALARLIV--------------------------------------GLVLLD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----HLYNY-E--NIPVGRAEIEIATVMPSGNREL LTPPPQPEEA-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LI >XP_018893579.1 epiphycan [Gorilla gorilla gorilla] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLAGLVL--------------------------------------GLVIFD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----NLYNY-E--NIPVDQVEIEIATVMPSGNREL LTPPPQPEKAQEEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPHTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLTFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGS---------------------------- LV >XP_004083110.1 aggrecan core protein [Oryzias latipes] ------------------------------------------------------------ ------------------------------------------------------------ -------MRMFVRLVL--------------------------------------GLFVLK ------------------------------AAVASP-RF--------------------- -----------------------------------------------------------S RQANLDIYDDANYDEELN----NVESE--DTYDYED--GLTIDEPEIEIETMALPDYTFP -------EEE-KPEEG-------------------------------EEEELTLRPQPIP QGSGGSGVLMGPETQKEVELRQEPVDILHASGDL-------------------GGS-GSG ----SGT-SG-------ASGASGSGESGDLLI---------------------SGDIIL- ----------------ISGASETLISSEGSGEFLISE-KTDFTIPWHTSGSGFESSP--S GASG--------DLT--SGHSGISIEIPFGSGESGE---SGESGDL-----SGISPDPSI SGASGSSGVSGDPAESGDLGITLISGDEKPFVISKHEPQEASVASGEISGVS-------- ------SAD------------------------TEISGTSGVSGVSTSGD----DEEP-- --VTVIIETKEEERVLSTTPETPQEGATSIEETDSSGLPEPFEPKEPDEPKIDISGM-PT CLLCTC-LGTSVYCDDLKLDSVPP--LPKETTHFYARYNKITKINKSDFAFMNKLKRVDL TANEITAIDGTAFIGLPELEELVVRQNHLTQLP--ALPETMTLIDASHNSIGSKGIHKEA FK--------DMTGLLFLYLTDNNIDYIPVPL-----PESLRSLHLQ-----RNNIQMMH EDTFCNLNDFNYI------------------RNALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYVC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------IGN---------------------------- LI >XP_005508374.1 epiphycan [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ -------MQTFANIFL--------------------------------------GFFIFE ------------------------------SVGAAP------------------------ ------------------------------------------------------------ -ISDTVIYDSEFYDIPLG----ELP----HPFVYDE--NEPSDQLETEIGTALPSVIQES YSSAPLT----EEHEE-------------------------------EASTPKLIDGSSA QG---SGVL-GPQTQD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CILCTC-IGTTVYCDDHELDAVPP--LPKKTMYFYSRYNRIRKINRNDFANLNKLKRIDL TANFISEIHEDAFRRLPQLEELVLRDNRIRQLP--ELPSTLTLIDVSKNRLGRKGIRNEA FK--------DLHELQHLYITDNNLDHIPLPL-----PESLQALHLQ-----NNNIQEMH EDTFCKMKDFSYV------------------RRALEDIRLDGNPINL------------- ------------------SRTPY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------VGN---------------------------- LI >XP_005679865.2 PREDICTED: epiphycan [Capra hircus] ------------------------------------------------------------ ------------------------------------------------------------ -------MKALARLIV--------------------------------------GLVLLD ------------------------------AAVTAP------------------------ ------------------------------------------------------------ -TLESINYDSETYDATLE----DLD----HLYNY-E--NIPVGRAEMEIATVMPSGNREL LTPPPQPEEA-EEEEE-------------------------------EESTPRLIDGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDRELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRGNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FK--------DMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_006029354.1 epiphycan [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLANIFL--------------------------------------GFFIFE ------------------------------GIVAAP------------------------ ------------------------------------------------------------ -TIDTLTYDSDLYGIILG----ESD----NLFDHIE--NEQSAQAETEVGTILPFVTQDS YSSAPLT----EEPEE-------------------------------EASTPKLIDGSSP LG---SGVL-GPQTHD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CLLCTC-LGTTVYCDDHELNAIPP--LPKKTTYFYSRYNRIKKINRNDFANLNNLKRIDL TENFISEIDEDAFRKLPQLQELVLRNNKIRQLP--ELPATLTFIDISNNRLGRKGIRTEA FK--------DMIDLQHLYITDNNLDHIPLPL-----PESLQALHLQ-----NNNIQEMH EDTFCKMKDVTYV------------------RRALEDIRLDGNPINL------------- ------------------SKTPY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LI >XP_019336346.1 PREDICTED: epiphycan [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLANIFL--------------------------------------GFFIFE ------------------------------GIVAAP------------------------ ------------------------------------------------------------ -TIDTLTYDSDLYGIILG----ESD----NLFDHIE--NEQSAQAETEVGTILPFVTQDS YSSAPLT----EEPEE-------------------------------EASTPKLIDGSSP LG---SGVL-GPQTHD-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GL-PT CLLCTC-LGTTVYCDDHELNAIPP--LPKKTTYFYSRYNRIKKINRNDFANLNNLKRIDL TENFISEIDEDAFRKLPQLQELVLRNNKIRQLP--ELPATLTFIDISNNRLGRKGIRTEA FK--------DMIDLQHLYITDNNLDHIPLPL-----PESLQALHLQ-----NNNIQEMH EDTFCKMKDVTYV------------------RRALEDIRLDGNPINL------------- ------------------SKTPY------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LI >XP_015815457.1 PREDICTED: dentin sialophosphoprotein-like [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ -------MRMLVRLVL--------------------------------------GLFVLK ------------------------------AAIASP-RF--------------------- -----------------------------------------------------------S RQVDLDTYDLANYDEEED----NFDLDNGESYDYDE--ELTTDESETETETPNELDYNHP -PEDLEEEKP-EEEEDVQQEKGGEEENQEEKEEEDNHEEEYNQGEENEEEELPLTPQLIP QGSGGSGVLMGPDTQKEVELRRVPVDTLHVSGDF-------------------GGSAGSG ASGASGA-SG-------ASGASGSGGSGDILVSG---------------ASGESGEIIM- ----------------MSGASEELFSSGGPEELL----SGDILISGDLSGSGVTSGSGVS GFSG--------DIP--SGESEFVTELPVGSGGSGDPSGSGFSGDILISGASGISGASGI SGASGISGVSGDSFESGQSGITFITEEEERPLVPEIIPQEASGGSGEISGVSGTS---GA SGDIGVSGG------------------------LEVSGTSGTSGVSASGD----IEVPE- --VNLLPEPEEEEELLPTTPEPSQEVQTSIEETMTSG-----DPEQPEEEVVDAQGM-PV CLLCTC-LGGSVYCDDLKLDSVPP--LPKDTTHFYARYNKITKINKSDFANMNKLKRIDL TANEITAIDDKAFMGLPALEQLIIRENHVSQLP--ALPETMTLIDGSHNNIGSRGIHKEA FK--------DMTSLQFLYLTDNNIDYIPVPL-----PDSLRSIHLQ-----RNNIQMMH EDTFCNLNDFNYI------------------RNALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYIC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------VGN---------------------------- LV >XP_020750509.1 epiphycan isoform X1 [Odocoileus virginianus texanus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------------------------MPSGNREL LTPPPQPEEA-EEEEE-------------------------------EESTPRLIYGSSP QEPEFTGVL-GPQTNE-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------DF-PT CLLCTC-ISTTVYCDDHELDAIPP--LPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDL TSNLISEIDEDAFRKLPQLRELVLRDNKIRQLP--ELPTTLRFIDISNNRLGRKGIKQEA FKALHLERLQDMYDLHHLYLTDNNLDHIPLPL-----PENLRALHLQ-----NNNILEMH EDTFCNVKNLTYI------------------RKALEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AYMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRLP-------- -----------------------------IGS---------------------------- LV >XP_040200080.1 epiphycan [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ -------MKTLANIFL--------------------------------------GLLIIK ------------------------------AVVSAP------------------------ ------------------------------------------------------------ -PTDSVNYDTAAYEVDL------LY----NLYDYDE--NTNIDQGEIEIGTVLPVVNRPI LSPEPVQE---EIEEE-------------------------------EESTPKLIDGSSP QGPLSPGV---PEASG-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------GV-ST CILCGC-IRTTVYCDDHNLDAVPP--LPKDTTHVYLRFNRISKINKNDFSYLSKLQKIDL TSNIISDIDEDAFRSLSQLDELILLDNNIRQLP--ELPHSVSFLDVSKNRLGRKGIKQEA FK--------DLNDLRLLYLNNNNLDHIPIPL-----PDSLQALHLQ-----DNNIQEMH EDTFCNMKDFTYA------------------RRSLEDIRLDGNPINL------------- ------------------SKTPQ------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----AFMC---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------LPRIP-------- -----------------------------VGR---------------------------- LV
BMGE Cleaned alignment of selected proteins >NP_004941.2 epiphycan precursor [Homo sapiens] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLENLYNYNIPVDKVEIEIATVMPSGNRELLTPPPQPEKAEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_043303229.1 epiphycan [Cervus canadensis] MKALASLIVGLVILGAAVTAPTLESINYDSENYDATLEHLYSYNIPVGRAEIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >KAB0378011.1 hypothetical protein FD755_009589 [Muntiacus reevesi] LKEKPSLTRFSNFIKVPCIVKALKKVNF---------------NIPI--LLIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >KAB0364801.1 hypothetical protein FD754_008957 [Muntiacus muntjak] ----------------MLTTSCLEQISHPKFQ---------------GQQEIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLTRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_018109796.1 epiphycan S homeolog isoform X1 [Xenopus laevis] MKTFVNLFLGLFILQTALAAPTIETINYDTDTYEDVLDSLYDYNPIVDQGKIEIGTVLPVVNRPILSPEQVPE--ETEEAEESTPKLIDGSSPQGPLTPGVQGPDTSGPTCILCACLITTVYCDDHNLDTIPPLPKETTHVYLRFNRISKISKHDFNHLTKLKKIDLTSNIISEIDEDAFRNLPQLSELILRDNNIRQLPELPNTMNFIDVSNNRLGSKGIKQEAFKDMTDLHILYLTNNHLNHIPIPLPDNLQSLHLQDNNIQEMHEDTFCKMKDWTYARRTLEDIRLDGNPINLSRTPQLPRIPV >KAF4010142.1 hypothetical protein G4228_001458 [Cervus hanglu yarkandensis] LKKLLFLFLNLTLLDALRNMPIRKSINYDSENYDATLEHLYSYNIPVGRAEIEIATVMPSGNRELLTPPPQPEEPEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNE---------------------------------------------------DDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_030296407.1 epiphycan isoform X3 [Sparus aurata] MRMLVRLVLGLLVLKAVVAGPQVDLDSYDSANYDVDLDDIYDYGLTIDDPQIEIGTLAPPDYNYPVPEASLEEQEQEEEEEEEEMPLKPQLIPQGSGGSGVLGPDTQKPTCLLCTCLGGSVYCDDLKLDSVPPLPKDTTHFYARYNRITKINKSDFAFLNKLKRIDLTANEITSVDDRAFMALPELEELVIRENHISQLPALPETMTLIDASHNNIGTKGIHNEAFKDMTSLLYLYLTDNHVDYIPVPLPDSLRSLHLQRNNIQMMHEDTFCNLKDFNYIRNALEDIRLDGNPINLSRTPQLPRIPI >OWK08495.1 OPTC [Cervus elaphus hippelaphus] MKLLALLSLLILMLQEAGTASLSKEEREEDQPYGEGDSSLDNYDPSNYDKLTDYGDQLPQVKGTGLASLTRT---RFTQSTEVARTLPSNPTMGRPPTLGLLAAPTDLPTCLICVCLGSSVYCDDTELENIPPLPQTTAYLYARFNRISHIRAGDFKGLTKLKRIDLSGNSISSIDDKALRLLPALRDLILPENKLTALPMLPTSIEVLDVRMNRLQSSGIQPEAFRALEKLQFLYLADNLLDAIPRSLPLSLRSLHLQGNKGVERH-------------RRWRSDCR---------EPPSLRH--- >XP_038060753.1 leucine-rich repeat transmembrane neuronal protein 1-like [Patiria miniata] MSNRSFLRLVVCILS-----------------------QLYFY---------------------------------------------------------ILRP----ACPVRCDCVKGEVNCTDVNLEGLPSLPSNIHFLYLGSNFISSVNEDDFQDLSDLKQLHLARNRISQLQTSAFRPLQILQVLDLRFNRINQIPAFTGLVSLIELNLGGNGIGSISRDAFAEMQSLEVLNLSDSNLRVSGLPAARNLKWLDIEGSELRRVPNGMFEHLSNLTYLLRSMQTLIMEGCELSFEKTPHLPRTSV >NP_001366385.1 epiphycan precursor [Mus musculus] MGMLARVALGLIIIDAVLAAPTTELFNYDSEVYDAILETFYNYHIPDNHVENEKVSERLSGNRELLTPGPQLGDNDEDKDEESTPRLIDGSSPQEPEFPGLLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKKTTYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPHLQELVLRDNKIKQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPESLRALHLQNNDILEMHEDTFCNVKNLTYVRKALEDIRLDGNPINLSRTPQLPRLPI >NP_776732.1 epiphycan precursor [Bos taurus] MKALARLIVGLLILDAAVTAPTLESINYNSETYDATLEHLYNYNIPMGRAEIEIATVMPSGNRELLTPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNIMEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >NP_001101558.1 epiphycan [Rattus norvegicus] MRMAARIVLVLIIIDATLAAPTTELFNYDSEVYDAILETFYNYHIPDNQVETEKVAERLSGNRELLTPGPQLGDSDEDKDEESTPRLIDGSSPQEPEFPGLLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKKTTYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRNLPRLQELVLRDNKIKQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYITDNSLDHIPLPLPENLQALHLQNNDILEMHEDTFCNVKNLTYVRKALEDIRLDGNPINLSKTPQLPRLPI >XP_025003921.1 epiphycan isoform X1 [Gallus gallus] MKTFVNIFLGFFIFESVGAVPITDTVTYDSEFYDVSLGHPFVSNDQSDQVETEIGTAIPSIIQESYSSAPLT---EEPEEEASTPKLIDGSSAQG---SGVLVPQTQDPTCLLCTCLGTTVYCDDRELDAVPPLPKNTMYFYSRYNRIRKINKNDFANLNNLKRIDLTANLISEIHEDAFRRLPQLLELVLRDNRIRQLPELPSTLTLIDISNNRLGRKGIRNEAFKDLHELQHLYITDNNLDHVPLPLPESLQALHLQNNNIQEMHEDTFCKMRDFSYVRRALEDIRLDGNPINLSKTPYLPRLPI >XP_001134960.1 epiphycan [Pan troglodytes] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLENLYNYNIPVDQVEIEIATVMPSGNRELLTPPPQPEKAEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLQALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >NP_001017903.3 epiphycan isoform 1 precursor [Danio rerio] MVSLRLMWV-LLVLCVAAASPQTELHNYDDNN-DVDLDAYEDY---GNESEIEITRVDPFEGIESSHSA------SLEEKEEEELPIKPQLIPPSSGASGTLGPSAQGSVCVLCTCLVGSVYCDDLKLDRVPPLSKDTTHFYSRYNKISRISKSDFANLNKLKKIDLTSNGISRIDDDAFFGLPSLEELILRENNIRQLPALPPSMTLIDVCHNHLGSTGIQREAFKDMPGLLYLYLTDNNIDHIPVPLPESLRSLHLQNNNIQMIHEDTFCNPHDLNYIRNALEDVRLDGNPINLSRTPQLPRIPF >XP_020948689.1 epiphycan isoform X2 [Sus scrofa] MKTLARLILGFVILDAAVTAPTLESINYDSETYDATLENLYNYNIPMGPAEIDVATVMPSGNRELLTPPPQPEEA-EEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKTTAYFYSRFNRIKKINKSDFANLNDLRRIDLTSNLISEIDEDAFRKLPQLQELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLRHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_002711429.1 PREDICTED: epiphycan [Oryctolagus cuniculus] MNILASLILGLVFFDAAVTAPTPDSINYDSETYGATLENLYNYNIPIEQAESEIATMMPSGNSELLTLPPKPEETQEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNVTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_024112745.1 epiphycan [Pongo abelii] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLENLYNYNIPVDQVEIEIATVMPSGNRELLTPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYARFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_010707300.2 epiphycan [Meleagris gallopavo] MKTFVNIFLGFFIFEYVGAVPITDPVTYDSEFYDVSLGHPFVYNEQSDQLETEIGTAIPSIIQESYSSAPLT---EEPEEEASTPKLIDGSSAQG---SGVLVPQTQDPTCLLCTCLGTTVYCDDHELDAVPPLPKKTMYFYSRYNRIRKINKNDFANLNNLKRIDLTANLISEIHEDAFRRLPQLQELVLRDNRIRQLPKLPSTLTFIDVSKNRLGRKGIRNEAFKDLHELQHLYITDNNLDHVPLPLPESLQALHLQNNNIQEMHEDTFCKMRDFTYVRRALEDIRLDGNPINLSKTPYLPRLPI >XP_013975233.1 epiphycan [Canis lupus familiaris] MKMLARLILGLVIFDAAVTAPTLEPINYDSETYDATLENLYNYNIPIGQAEIEIATVMPSGNRELLTPPPQPEEA-EEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLDDLRRIDLTSNLISEIDEDAFRKLPHLRELVLRDNKIRQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_003823452.1 epiphycan [Pan paniscus] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLENLYNYNIPVDQVEIEIATVMPSGNRELLTPPPQPEKAEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLQALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_003989156.1 epiphycan [Felis catus] MKTLARLILGLVIFDAAVTAPTLDPINYDSETYDATLDNLYNYNIPIGQAEIEIATVMPSGNRELLTPPPQPEEA-EEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPNTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_014950074.1 epiphycan [Ovis aries] MKALARLIVGLVLLDAAVTAPTLESINYDSETYDATLEHLYNYNIPVGRAEIEIATVMPSGNRELLTPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPI >XP_018893579.1 epiphycan [Gorilla gorilla gorilla] MKTLAGLVLGLVIFDAAVTAPTLESINYDSETYDATLENLYNYNIPVDQVEIEIATVMPSGNRELLTPPPQPEKAEEEEEEESTPRLIDGSSPQEPEFTGVLGPHTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLSDLKRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLTFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_004083110.1 aggrecan core protein [Oryzias latipes] MRMFVRLVLGLFVLKAAVASPQANLDIYDDANYDEELNDTYDYGLTIDEPEIEIETMALPDYTFP-------EEEKPEEGEEEELTLRPQPIPQGSGGSGVLGPETQKPTCLLCTCLGTSVYCDDLKLDSVPPLPKETTHFYARYNKITKINKSDFAFMNKLKRVDLTANEITAIDGTAFIGLPELEELVVRQNHLTQLPALPETMTLIDASHNSIGSKGIHKEAFKDMTGLLFLYLTDNNIDYIPVPLPESLRSLHLQRNNIQMMHEDTFCNLNDFNYIRNALEDIRLDGNPINLSKTPQLPRIPI >XP_005508374.1 epiphycan [Columba livia] MQTFANIFLGFFIFESVGAAPISDTVIYDSEFYDIPLGHPFVYNEPSDQLETEIGTALPSVIQESYSSAPLT---EEHEEEASTPKLIDGSSAQG---SGVLGPQTQDPTCILCTCIGTTVYCDDHELDAVPPLPKKTMYFYSRYNRIRKINRNDFANLNKLKRIDLTANFISEIHEDAFRRLPQLEELVLRDNRIRQLPELPSTLTLIDVSKNRLGRKGIRNEAFKDLHELQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDFSYVRRALEDIRLDGNPINLSRTPYLPRLPI >XP_005679865.2 PREDICTED: epiphycan [Capra hircus] MKALARLIVGLVLLDAAVTAPTLESINYDSETYDATLEHLYNYNIPVGRAEMEIATVMPSGNRELLTPPPQPEEAEEEEEEESTPRLIDGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDRELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRGNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_006029354.1 epiphycan [Alligator sinensis] MKTLANIFLGFFIFEGIVAAPTIDTLTYDSDLYGIILGNLFDHNEQSAQAETEVGTILPFVTQDSYSSAPLT---EEPEEEASTPKLIDGSSPLG---SGVLGPQTHDPTCLLCTCLGTTVYCDDHELNAIPPLPKKTTYFYSRYNRIKKINRNDFANLNNLKRIDLTENFISEIDEDAFRKLPQLQELVLRNNKIRQLPELPATLTFIDISNNRLGRKGIRTEAFKDMIDLQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDVTYVRRALEDIRLDGNPINLSKTPYLPRLPI >XP_019336346.1 PREDICTED: epiphycan [Alligator mississippiensis] MKTLANIFLGFFIFEGIVAAPTIDTLTYDSDLYGIILGNLFDHNEQSAQAETEVGTILPFVTQDSYSSAPLT---EEPEEEASTPKLIDGSSPLG---SGVLGPQTHDPTCLLCTCLGTTVYCDDHELNAIPPLPKKTTYFYSRYNRIKKINRNDFANLNNLKRIDLTENFISEIDEDAFRKLPQLQELVLRNNKIRQLPELPATLTFIDISNNRLGRKGIRTEAFKDMIDLQHLYITDNNLDHIPLPLPESLQALHLQNNNIQEMHEDTFCKMKDVTYVRRALEDIRLDGNPINLSKTPYLPRLPI >XP_015815457.1 PREDICTED: dentin sialophosphoprotein-like [Nothobranchius furzeri] MRMLVRLVLGLFVLKAAIASPQVDLDTYDLANYDEEEDESYDYELTTDESETETETPNELDYNHP-PEDLEEEKPEEEEDEEEELPLTPQLIPQGSGGSGVLGPDTQKPVCLLCTCLGGSVYCDDLKLDSVPPLPKDTTHFYARYNKITKINKSDFANMNKLKRIDLTANEITAIDDKAFMGLPALEQLIIRENHVSQLPALPETMTLIDGSHNNIGSRGIHKEAFKDMTSLQFLYLTDNNIDYIPVPLPDSLRSIHLQRNNIQMMHEDTFCNLNDFNYIRNALEDIRLDGNPINLSKTPQLPRIPV >XP_020750509.1 epiphycan isoform X1 [Odocoileus virginianus texanus] ---------------------------------------------------------MPSGNRELLTPPPQPEEAEEEEEEESTPRLIYGSSPQEPEFTGVLGPQTNEPTCLLCTCISTTVYCDDHELDAIPPLPKNTAYFYSRFNRIKKINKNDFASLNDLRRIDLTSNLISEIDEDAFRKLPQLRELVLRDNKIRQLPELPTTLRFIDISNNRLGRKGIKQEAFKDMYDLHHLYLTDNNLDHIPLPLPENLRALHLQNNNILEMHEDTFCNVKNLTYIRKALEDIRLDGNPINLSKTPQLPRLPV >XP_040200080.1 epiphycan [Rana temporaria] MKTLANIFLGLLIIKAVVSAPPTDSVNYDTAAYEVDL-NLYDYNTNIDQGEIEIGTVLPVVNRPILSPEPVQE--EIEEEEESTPKLIDGSSPQGPLSPGV--PEASGSTCILCGCIRTTVYCDDHNLDAVPPLPKDTTHVYLRFNRISKINKNDFSYLSKLQKIDLTSNIISDIDEDAFRSLSQLDELILLDNNIRQLPELPHSVSFLDVSKNRLGRKGIKQEAFKDLNDLRLLYLNNNNLDHIPIPLPDSLQALHLQDNNIQEMHEDTFCNMKDFTYARRSLEDIRLDGNPINLSKTPQLPRIPV
PhyML tree of selected proteins (XP_018109796_1_epiphycan_S_homeolog_isoform_X1__Xenopus_laevis_:0.15661033,XP_040200080_1_epiphycan__Rana_temporaria_:0.15058443,((((OWK08495_1_OPTC__Cervus_elaphus_hippelaphus_:2.20479868,XP_002711429_1_PREDICTED__epiphycan__Oryctolagus_cuniculus_:0.00000002):0.05707036,(((XP_020948689_1_epiphycan_isoform_X2__Sus_scrofa_:0.03206883,(XP_020750509_1_epiphycan_isoform_X1__Odocoileus_virginianus_texanus_:0.0052849,(NP_776732_1_epiphycan_precursor__Bos_taurus_:0.01107827,((XP_014950074_1_epiphycan__Ovis_aries_:0.00330211,XP_005679865_2_PREDICTED__epiphycan__Capra_hircus_:0.01013663):0.00323364,(XP_043303229_1_epiphycan__Cervus_canadensis_:0.00340311,(KAF4010142_1_hypothetical_protein_G4228_001458__Cervus_hanglu_yarkandensis_:0.05493648,(KAB0364801_1_hypothetical_protein_FD754_008957__Muntiacus_muntjak_:0.03997854,KAB0378011_1_hypothetical_protein_FD755_009589__Muntiacus_reevesi_:0.07891279):0.04836425):0.01822578):0.01362924):0.00260869):0.00000001):0.02033684):0.0097388,(XP_003989156_1_epiphycan__Felis_catus_:0.00678969,(XP_013975233_1_epiphycan__Canis_lupus_familiaris_:0.0063436,(NP_001101558_1_epiphycan__Rattus_norvegicus_:0.02879739,NP_001366385_1_epiphycan_precursor__Mus_musculus_:0.02781942):0.19245457):0.00722811):0.00729384):0.00619045,((NP_004941_2_epiphycan_precursor__Homo_sapiens_:0.00330917,(XP_018893579_1_epiphycan__Gorilla_gorilla_gorilla_:0.00000001,(XP_001134960_1_epiphycan__Pan_troglodytes_:0.00000001,XP_003823452_1_epiphycan__Pan_paniscus_:0.00000001):0.00329933):0.00000001):0.0033154,(XP_038060753_1_leucine_rich_repeat_transmembrane_neuronal_protein_1_like__Patiria_miniata_:4.23156489,XP_024112745_1_epiphycan__Pongo_abelii_:0.00000001):0.00331653):0.01524268):0):0.17872156,((XP_006029354_1_epiphycan__Alligator_sinensis_:0.00000001,XP_019336346_1_PREDICTED__epiphycan__Alligator_mississippiensis_:0.00000001):0.08006393,(XP_005508374_1_epiphycan__Columba_livia_:0.04889406,(XP_010707300_2_epiphycan__Meleagris_gallopavo_:0.01476238,XP_025003921_1_epiphycan_isoform_X1__Gallus_gallus_:0.03028125):0.0317996):0.10732656):0.16154034):0.07857071,(NP_001017903_3_epiphycan_isoform_1_precursor__Danio_rerio_:0.43164216,(XP_030296407_1_epiphycan_isoform_X3__Sparus_aurata_:0.0614394,(XP_004083110_1_aggrecan_core_protein__Oryzias_latipes_:0.12543111,XP_015815457_1_PREDICTED__dentin_sialophosphoprotein_like__Nothobranchius_furzeri_:0.13901638):0.04720215):0.16672964):0.47334138):0.15548384);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)