PB0037

DATABASE

Click here to access PB0037 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0037	P22413	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	ARHR2, COLED, M6S1, NPP1, NPPS, PC-1, PCA1, PDNP1	Homo_sapiens	Not able to hydrolyze the 2'-3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812).

Domains

Gene Ontology

PF01033 (2_Somatomedin_B) PF01223 (Endonuclease_NS) PF01663 (Phosphodiest)

GO:0003676 (enables) nucleic acid binding GO:0003824 (enables) catalytic activity GO:0004527 (enables) exonuclease activity GO:0004528 (enables) phosphodiesterase I activity GO:0004551 (enables) nucleotide diphosphatase activity GO:0005044 (enables) scavenger receptor activity GO:0005158 (enables) insulin receptor binding GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0005524 (enables) ATP binding GO:0008270 (enables) zinc ion binding GO:0016787 (enables) hydrolase activity GO:0030247 (enables) polysaccharide binding GO:0035529 (enables) NADH pyrophosphatase activity GO:0036218 (enables) dTTP diphosphatase activity GO:0042803 (enables) protein homodimerization activity GO:0046872 (enables) metal ion binding GO:0047429 (enables) nucleoside-triphosphate diphosphatase activity GO:0050656 (enables) 3'-phosphoadenosine 5'-phosphosulfate binding GO:0106177 (enables) cyclic-GMP-AMP hydrolase activity GO:0006091 (involved in) generation of precursor metabolites and energy GO:0006796 (involved in) phosphate-containing compound metabolic process GO:0006897 (involved in) endocytosis GO:0006955 (involved in) immune response GO:0009143 (involved in) nucleoside triphosphate catabolic process GO:0030308 (involved in) negative regulation of cell growth GO:0030318 (involved in) melanocyte differentiation GO:0030500 (involved in) regulation of bone mineralization GO:0030502 (involved in) negative regulation of bone mineralization GO:0030505 (involved in) inorganic diphosphate transport GO:0030643 (involved in) cellular phosphate ion homeostasis GO:0030730 (involved in) sequestering of triglyceride GO:0031214 (involved in) biomineral tissue development GO:0031953 (involved in) negative regulation of protein autophosphorylation GO:0032869 (involved in) cellular response to insulin stimulus GO:0045599 (involved in) negative regulation of fat cell differentiation GO:0045719 (involved in) negative regulation of glycogen biosynthetic process GO:0046034 (involved in) ATP metabolic process GO:0046325 (involved in) negative regulation of glucose import GO:0046627 (involved in) negative regulation of insulin receptor signaling pathway GO:0050427 (involved in) 3'-phosphoadenosine 5'-phosphosulfate metabolic process GO:0090305 (involved in) nucleic acid phosphodiester bond hydrolysis GO:1990787 (involved in) negative regulation of hh target transcription factor activity GO:0005576 (located in) extracellular region GO:0005615 (located in) extracellular space GO:0005765 (located in) lysosomal membrane GO:0005886 (located in) plasma membrane GO:0005887 (located in) integral component of plasma membrane GO:0009986 (located in) cell surface GO:0016020 (located in) membrane GO:0016021 (located in) integral component of membrane GO:0016323 (located in) basolateral plasma membrane

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P22413|ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Homo sapiens OX=9606 GN=ENPP1 PE=1 SV=2 MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPL EKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNC RCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINY SSVCQGEKSWVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKK CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNPEW YKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLP KDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSC REPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNV FSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVY TPKHPKEVHPLVQCPFTRNPRDNLGCSCNPSILPIEDFQTQFNLTVAEEKIIKHETLPYG RPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPL SPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQVIWRYFHDTL LRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSF YQQRKEPVSDILKLKTHLPTFSQED >tr|B0JZL7|B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=enpp1 PE=1 SV=1 MDSAKRDEHMSEHAANLLGTGQRYTRTHNTAKVQSRYLKILCAVLLLGLLALILTIIFLL KLRCSDKVIDSCKNRCISKSHDGNAGCRCDAACVNEGTCCLDYEEVCLQPTQLWTCSKFR CGEDRLPSSLCSCSADCVKVGDCCANYKRTCEGEKSWLQEDCEDIRTPQCPAGFSKSPLL LVSLDGFRAGYMNAYSALLPAIRKLRECGTSTPYMRPAYPTKTFPNHYTIVTGLYPETHG IVDNKMYDVNRNASFSLKVDEKFNPLWYQGEPVWITAMKNHLKTATFFWPGSDVKVHGRY PDYWIKYNRNILFEKRIAQIFQWLHLPEGERPDFYTLYFEEPDASGHKYGPMSTQVIEAL INVDRLIGMLMDGLKERNLHKCVNVVLVSDHGMEEASCKKAAYVSNYLDNINDITVIQGP AARVRPRHVPEEFFSFDYEGLVKNLSCREPNQPMKPYLKEHLPKRLHFAKNIRIERAHLY MQPQWQAALKPSEIKYCRGGFHGSDNVFKNMQAIFIGYGPGIHYNTTVPPFENIEVYNLL CDLLGISPAANNGTHGSLNHILKKPRYQPVFPAERSAPSTCSAVSSSLRDPRGCTCDSLT EAEVNRLNQRLINSNSDSNVKPVHLPFGIPRVLQDQSDYCILHHSSYISGYSRDILMPLW VSYSLNTTVVLHPSAEWCVRADVRVQASDRQSCSIYKNNSSMSFGLLHPPNFSPAGTEPD SLITSNMVPMYPGFKDIWTHFHNFLLIKFSEEMNGINVVSGPIFDNDFDGNYDFMNKGVL NGAPIPTHFFIILTSCKNSSLSVRQCEGPLDAVSFILPHRPDHLETCHNGTDYSWFQDWV QLHVARIRDIELLTGLSFYHDRISVAETLQLKTRLKTF
Selected proteins from model organisms >NP_006199.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Homo sapiens] MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETC IEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERI LAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPY LKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIE ADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNP SILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKENTICLLSQHQFMSGYSQDILMPLWTSYTVDRN DSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQ VIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSD ILKLKTHLPTFSQED >CAE1329719.1 ENPP1_3 [Sepia pharaonis] MLRFYLSISFRVFFKRNLKIRASPSSAAFPRISTAEITNGITGACVWKELGNLVREYTVKYTTLNVISGPIFKDGLDNAK RLHSVNCSVPIPTHFYVILSKLSSADMSIPAEVLPIILPHVEKDQNCLKPKDYFFDHTARIRDIELLTGLTFMTDIPWEK SIKIRTYLPLEMWESLRPSSWMKLQHCVNLDKACKNASRPVLLISLDGFRADYTNYEVTPVINRLRECGIQTSFMRSSFP SKTFPNHYTIATGLYPESHGIVGNYMYDMEKNDVFKMSTTDPYWWGGETIWKTLSKAGKESGSYFFVGSSISGVNATYFY PYSGKTSYEDRIDQAVAWIRQGLPFVSIYFEEPDSTGHREGPSSKQILNTLRLVDSYIGQLMNKLYEENMHNCVNIIIVA DHGMTDVNCERSVVLWDIIDKETATKDMFVYSDGRVTNKYWQEGKTFKRFSNGSYAITVPELTSKLECSSRHMKVFQKEF LPKRLHYTKHKRIGDIQLLINDTWYLQRKNLYCGGRGSHGYDNRFKSMNALFLAYGPDFKQQLHTEPFQNIEIYNLFTDL LNIPGAPNNGTEGRLHRLLRRPPPETLRQSVGQYKNVSFNMNFDDLALFLKKHRCLNFTPTNKEVSLIYTSMVNSNKKFQ EISFGLPLLKNNVSIQMLKHKAYLTAYDTNRKRLLFIAATRKSSQPFANFSDAGNGCIVDPRVHFDQMKYDQTENNYTWL NLTPADFADDEEKITSFLSTNFIRVAKAFKEDLWIEALNVVQKWRTSFSMFTWFVGPIYDYNLDGLADDDDTIKRFTNES LPTNVFFVLVGCQNTGEIEATTAYILPSNQQHFPKCRKMSQMLRDHQARVRDVELLTNLEFYPKEPFQKAVIHRTSMIDV KLPLKD >XP_031562620.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like isoform X3 [Actinia tenebrosa] MKQAIKSIIILTLLILLLCNSLGAKINSKSTVLLISFDGFRWDYMDKTETPNFDSIVKTGVKAKYVKNAFVTKTFPNHFT IVTGLYEESHGIVANTMYDPEFKSWFYLNNTEPRWWNGGEPVWITNQNSGGTSGTVFWPGSNVEIRGQYPTYYLKYDHNL XYRDRVDKVVDLLTKKXPPTLLTLYFEEPDHSGHTYGPESKEVVKAIRTADNVTGYLINHLKAKGLFDKINIIITSDHGM TEISVNNTVYLQDYVPSEWYVPITAKEWDSFTLIKPKNGYKENIYNRLKNVSHIKVYKKEAIPMEYHYTNNRRIMPILVV GEEGWSVALSRKVKFKDKGNHGYSNKYESMHPFFIAHGPAFKSGYLSEPFKNVDIYPLMCHILGIKPAXNNGSLADVQQL LRNEIQTVAFFTISPMITTKKKMRVAFIV >XP_039259773.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like [Styela clava] MGRNPQIFVKTFLYAILIIFQLAVCEHTPKLLLISFDGFRWDYLSKTDTPNFDRITNNGVRAKWIKDSFTSLTFPNHYTI ATGLYEESHGIVANIFYDPVFNETFQIGNETTVLDGKFWGGEPIWVTNQLQGGRTGVYYWPGSEAEIKGVRPNIYEKYIQ QEVSMALWRNRTDTVIEWLTDPENVVDLALLYFKEPDHTGHIYGPESPEVVQMIQQCDNITGYILDQIEEHGLSNLLNII ITSDHGMTGMNRSRFITLDDHIDTHQTKHLINYIVGTSVWPKSGENITEELYKNLSSIDPEHVQVWMKKDIPPEYHYANN RRIAPILMSANEGWGIKENWNDTHYLLGRHGFNNSKMDMHPFFVATGPVFKKGFISEPFENVNIYSLMCHILGINPAPNN GSLDAVKQLLADEYIPDEEYKYTQLQFTIAKWAGICFGAIIVIVLLIYVIKELKMNSQMRKEVSGFSNSNLKYSERDENR EPLLSTDFP >XP_797859.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [Strongylocentrotus purpuratus] MLSALSFFLAVAVVITIGDTSAATGNDNGDDQELLLLVVFDGFRYDYLEKTATPNFDRLVNMGAKPAGMTPAFATKTFPG HHTIATGLYQENHGIIGNNMYDPEFNSTFGQANNEPRWWNYGGEPIWVTNQINGGRTVSVFWPGDRVNISGMTATYHQPA YDGSFPNEDRIDLVVGLMSNGSANLGILYFSEPDNTGHLQGPESNETANSIADCDETLGYLLEKLTEADLLDDVNIIVTS DHGMASVSPDQTVFLDDYVDRSLYFYTNNDPVFGLWPYDENSTEELYDALKDAHPNMDVYLKAEIPEEYHYRDNRRTSPI LVVMEEGWHVWTNSSIEGNWQRYKGNHGFLNTLESMRSIFIASGPAFKSNYASNDLLDAVDVYNLMCHLLAVDPAPNNGT FSHVEPLLANEGTGTSPETAETTLQMTTEGSGGRIAYSAHLLSLVFAIFLAFYF >NP_001129885.1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans] MVVIVVIVLLLTQLKAANSNAQNAMSSSKVQLEELTRKLSQPLEQLGPTLERLSNMPGFPMGPSPTTQTPPGVPPISPIV TGPNTTPESPRRSPKARYEWKGCQNLGKCELSGYTKPPLVILSLDGFAREYVDRNIVQTLNHIADCGVKADKVYPSYPSK TFPNHYSIVTGLWPESHGITDNSVFDPTISPVLESMKSTKYEKFFEGEPIWSVYKRKTGKKANCLFWVGCAYNNSGYAPD VAPAYNQELPFRNRIDTVVEWLKLPVDERPGLITAYLHEPDNAGHYQVDEEDVDEKLAEIDENLDYLMSRLSEEKLLECI NFAILSDHGMQLIDKTYYFQDYLDLKGLITAKGVVGRVYINDTTISVNDVVDKFRCKIDTVKTNTRSDVPTRKHYSRDPR VGEVLLEGRAGVTFYKSKADDYELSGDHGYDYFNPKMHTIFYARGPSFKQNTTISPYQNIQYMNLWMNLLGIEGAVETNG TIGFFDNILTNPPRRDNPTNVIGECPMIAFPSVLKCSGNVSAETLNQLSVKLTNCAFSPTNIPLYSDNHCFQNYCDNSVI VSRKGNDARRAIIEVLSRDEASNPSNFTFLNAKYQSNCPSHIPTGSLTIRQNSQLSSMVDERIDVPNNFLLKVLDPLQAK SMEYLNKFGKMYVISGTATDINHDGIADSNGSVITHIYRIMLICNSTWLLMNPPLCTDSDSMDTLSFIFPITEQSTIDCM SSDDILLDYTATIFDVERISGFQFGIGALSQNQNTIIRRKISTKLW >XP_038076960.1 bis(5'-adenosyl)-triphosphatase enpp4-like [Patiria miniata] MAAWWWKLGPVNVLLCSFLLTVFSASPYYKQAPSTSDAPLVLLVSFDGFRWDYLDRNKTPSFDSFVRDGVKAKYLFDTFA SKTFPNHYTIATGLYQESHGIVGNNMYNVSTGAKFTLRHKFNSSWWEGGEPIWVTNQNQGGHSGLIMYPGMEIQIRGQYP SYRLPKYNSTFPYEERINIMTRLFANGSINLGLLYFREPDHSGHMLGPNSPDMDAVIQMCDETLGYLMKKLRDAGLGDRV DVIVTSDHGMTPVSKDNFTQLDDFVDPELYYYTDNNPVIGIWPHKESDVDVIYNKLQGASPHVSVYLKDEIPAQYHYRDN PRIAPILLVAKEGWAIHVGNKTGSHFLNYKGNHGFNNSLMSMHPIFVARGPSFRQGLLVEPFENVNIYPLICKILGLEPA PNNGSLENVQDLLKYSELVTIMTTNEKGIITEPPPSTWSTGTVIGIAVAGAILLVAACLLLAMCARQRSYRQQPREYTPI ADTSLEGVDEIADSGFSSYNYPNTKI >XP_006560637.2 bis(5'-adenosyl)-triphosphatase enpp4 isoform X1 [Apis mellifera] MNSVIIFALTLVILFNVKYGLLISQHPKLLVVSFDAFRYDYFNRNLTPFMNKLRHEGTHADYMMNIFVTKTFPNHHTMAT GLYAETHGVIDNEYYDVISGNTTKYSYNLYHYDNKVLPIWTANEKGGAQRRSGSMMWPGGIYEYQGITPTFTQNFNENIP WEERIDTLISWFIHPIHPINFGILYIEEPDYHGHGIGIKGLEFDNILRKLDNITKYLHNKIEYHGLNDLNVVHLSDHGMA TVKLDRIIDLTKYINSSDYKFVGTSPGLHIFPNPGKEETIYQTLKQIASKLKKFRVYRREEIPKKYHYGNNTRIGPIFVI AEVGYAFQNLLDNIEFYKKKFNITVNNDSEFGLHGYDNEAIEMHPFFFAKGPAFMSNCKLEPFNNLDLYPLFCKILDLQC PIVNGTLLHLTKCLKKHQQDITVIAYRMIFIATIISMSMVGVIGAIVMFYMRKRRLGVRSYRRILEDLEAQYHWDENHDI ENATCKLKNFPDLFIISCYAKNKHLYAYKGNVKYRKTLFHCR >XP_043313008.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Cervus canadensis] MERDGCAGGGSRGGEGGRGPREGLAGNGRDPGSGRAAEASGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL VLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLS RSLCSCSDDCKDKGDCCVNHGSVCRGEKSWAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKT CGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSKEKFNPEWYKGEPIWLTAKHQGLKTGTF FWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMV GMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKDVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSC QEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNAFSNMQALFIGYGPGFKHSTE VDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVRSLGQCPFPRAPRESLDCSCDPSILPIVDFQT QLNLTMAEEKTIKRGALPYGRPRVLRNSTVCLLYQHQFVSGYSQDIVMPLWTSYTIDRNDSFFTEDFSNCFYQDLRIPVS PVHKCSFYKNNAKLSYGFLSPPQLHKGSSQVYSEALLTTNIVPMYQSFQVIWNYLHGTLLQRYAEERNGLNVVSGPVFDS DYDGRYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCENLDPLAFILPHRTDNRESCAHGKHESLWVEEL LKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >KAB0379402.1 hypothetical protein FD755_007186 [Muntiacus reevesi] MERDGCAGGGSRGGEGGRGPREGLAGNGRDPGSGRAAEASGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL RIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEKSWAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEY LHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSKEKFNPEWYKGE PIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGP VSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKDVKVVYGPAARLRPSDVPD KYYSFDYEGIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNAFSNM QALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVRSLVQCPFARAPRESL DCSCDPSILPIVDFQTQLNLTMAEEKTIRRGALPYGRPRVLRNSSVCLLYQHQFVSGYSHDILMPLWTSYTIDRNDSFFT EDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSSQVYSEALLTTNIVPMYQSFQVIWNFLHGTLLQRYA EERNGLNVVSGPVFDSDYDGRYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCENLDPLAFILPHRTDNS ESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >KAB0356465.1 hypothetical protein FD754_000621 [Muntiacus muntjak] MERDGCAGGGSRGGEGGRGPREGLAGNGRDPGSGSAAEASGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL RIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEKSWAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEY LHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSKEKFNPEWYKGE PIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGP VSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKDVKVVYGPAARLRPSDVPD KYYSFDYEGIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNAFSNM QALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVRSLVQCPFARAPRESL DCSCDPSILPIVDFQTQLNLTMAEEKTIRRGALPYGRPRVLRNSSVCLLYQHQFVSGYSHDILMPLWTSYTIDRNDSFFT EDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSSQVYSEALLTTNIVPMYQSFQVIWNFLHGTLLQRYA EERNGLNVVSGPVFDSDYDGRYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCENLDPLAFILPHRTDNS ESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_018118655.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Xenopus laevis] MMSKQMDCSLCLFTPSSEWRAERMGLSGWRQERESSSNCTESDIRAAAREAGGTAVNGSKACGTDTEQQQQQLGWWGKDI RDMESGGRNGSTGGETLEQSMLNPMTLVEDPGRGSHSAKKKKSNKWKVLSLVICVCLLTAILGCIFGLKPSCTREVTSCK GRCFERKFGSCRCDSACVELGNCCLDYQDVCIQPAYIWTCEKLRCGEKRLTGSLCSCSDDCSEIQDCCVNYNAVCRGNKS WSEETCEEIQTPQCPSGFSKPPLLLFSLDGFRSEYLHTWGELLPVISKLRKCGTYTTNLRPVYPSKTFPNHYSIVTGLYP ESHGLVDNKMYDPKRNAFFTLRNTEKFHPSWYQGEPIWITAMNQGLKAATFFWPGSDVKIKGTYPNIYKMYNSTVKFEER VMSILRWLRLPEQERPHFYTLYLEEPDHSGHGHGPVSSAVIKALMGVDRIVGMLMDGLKQMQLDKCINLILASDHGMEEA RCENVAFLSSFLEPSDSFIVIPGPAARLRPTKLPDEYFSFDYTGIAKKLTCREPNQHFKAYFKQNLPKRFHFAKNDRIEL LNFYTDPKWQVAKTKSDAKTCVGGFHGSDNRFESMQALFIGFGPGFKFKTEVEPFENIEIYNLMCDLLGITSATNNGTHG SLNHLLKNPVYMPSLPHEISDPFQCSVIHGANTDSLGCSCDSTNLTVFGSEQPMTLTPQQESETKKQNLPFGRPVVVQNS SYCILYHEQYVSGYSYHISMPLWTSYTVGKHAHSVDSGSSCIFADVRIPSNHSQSCHHYQKHYFLKYGFLYPPGLKESSG DSYAGLLTSNIVPMYPAFQVIWNHFHNVLLMKYADKKNGVHVISGPIFDSDFDGQFDTLEQINKITEDATVYIPTHYYIV LTSCKNASQTLQQCAGALDVLSFIVPHRIDNSESCASGKNESLWVEKLLHFHAARVKDVELLTGLSFFHNSKYSVNEILQ LKTFLPSSM >KAF4024570.1 hypothetical protein G4228_016567 [Cervus hanglu yarkandensis] MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNC CLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEKSWAEEECDSIDEPQCPAGFETPPT LLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAYFALKS KEKFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYL EEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKDVKVVYG PAARLRPSDVPDKYYSCKSISCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSD NAFSNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVRSLGQCPFPR APRESLDCSCDPSDSFFTEDFSNCFYQDLRIPVSPVHKCSFYKNNAKLSYGFLSPPQLHKGSSQVYSEALLTTNIVPMYQ SFQVIWNYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQ CENLDPLAFILPHRTDNRESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_010707567.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X6 [Meleagris gallopavo] MMKSPPGQITRACQPHQVISLFAFAFGVNVCMGFTTNRFRRSEEWDEGPISVLSDSPWISTSGSCKNRCFELQEAEPPGC RCDNLCKSYNSCCFDFDELCLKTARGWECTKDRCGETRNDDNACHCSEDCLSRGDCCTNYQVVCKGETHWVDDDCEEIKT PECPAGFVRPPLIIFSVDGFRASYMKKGNKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMY DPVFDASFSLRGREKFNHRWWGGQPIWITAAKQGVKAGTFFWSVVIPHERRILTILQWLTLPDNERPYVYAFYSEQPDAA GHRYGPFNSEMMVNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDTTCERTEFLSNYLTNVEDIILLPGSLGRI RPRSSNNLKYDPKVIVANLTCRKPDQHFKPYLKHHLPKRLHYAYNRRIEDVHLLVDRKWHVARKAVDVYKKPTGKCFFHG DHGYDNKINSMQTVFIGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRANVYKPTVPDEVAKPLY PVALPSASDFDIGCTCDDKKNKLDELNKRFHVKGTEEKHLLYGRPAVLYRTKYNILHHHDFESGYSETFLMPLWTSYTIS KQAEVSGVPEHLASCVRPDLRISPGNSQSCSAYRGDKQLSYGFLFPPQLSSSAEAKYDAFLITNIIPMYPAFKKVWNYFQ RVLVKRYATERNGVNVISGPIFDYDYDGLHDTPEKIKQFVEGSAIPVPTHYYAIITSCLDFTQPADKCDGPLSVLSYILP HRPDNDESCNSLEDESKWVEDLLKMHTARVRDIEQLTSLDFFRKTSRSYTEILSLKTYLHTFESEI >tr|B0JZL7|B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=enpp1 PE=1 SV=1 MDSAKRDEHMSEHAANLLGTGQRYTRTHNTAKVQSRYLKILCAVLLLGLLALILTIIFLL KLRCSDKVIDSCKNRCISKSHDGNAGCRCDAACVNEGTCCLDYEEVCLQPTQLWTCSKFR CGEDRLPSSLCSCSADCVKVGDCCANYKRTCEGEKSWLQEDCEDIRTPQCPAGFSKSPLL LVSLDGFRAGYMNAYSALLPAIRKLRECGTSTPYMRPAYPTKTFPNHYTIVTGLYPETHG IVDNKMYDVNRNASFSLKVDEKFNPLWYQGEPVWITAMKNHLKTATFFWPGSDVKVHGRY PDYWIKYNRNILFEKRIAQIFQWLHLPEGERPDFYTLYFEEPDASGHKYGPMSTQVIEAL INVDRLIGMLMDGLKERNLHKCVNVVLVSDHGMEEASCKKAAYVSNYLDNINDITVIQGP AARVRPRHVPEEFFSFDYEGLVKNLSCREPNQPMKPYLKEHLPKRLHFAKNIRIERAHLY MQPQWQAALKPSEIKYCRGGFHGSDNVFKNMQAIFIGYGPGIHYNTTVPPFENIEVYNLL CDLLGISPAANNGTHGSLNHILKKPRYQPVFPAERSAPSTCSAVSSSLRDPRGCTCDSLT EAEVNRLNQRLINSNSDSNVKPVHLPFGIPRVLQDQSDYCILHHSSYISGYSRDILMPLW VSYSLNTTVVLHPSAEWCVRADVRVQASDRQSCSIYKNNSSMSFGLLHPPNFSPAGTEPD SLITSNMVPMYPGFKDIWTHFHNFLLIKFSEEMNGINVVSGPIFDNDFDGNYDFMNKGVL NGAPIPTHFFIILTSCKNSSLSVRQCEGPLDAVSFILPHRPDHLETCHNGTDYSWFQDWV QLHVARIRDIELLTGLSFYHDRISVAETLQLKTRLKTF >NP_032839.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 2 [Mus musculus] MERDGDQAGHGPRHGSAGNGRELESPAAASLLAPMDLGEEPLEKAERARPAKDPNTYKVLSLVLSVCVLT TILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKR LSRFVCSCADDCKTHNDCCINYSSVCQDKKSWVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTW GGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNP LWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFY TLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLN KYLGDVNNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIE PLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLG LIPAPNNGSHGSLNHLLKKPIYNPSHPKEEGFLSQCPIKSTSNDLGCTCDPWIVPIKDFEKQLNLTTEDD DIYHMTVPYGRPRILLKQHRVCLLQQQQFLTGYSLDLLMPLWASYTFLSNDQFSRDDFSNCLYQDLRIPL SPVHKCSYYKSNSKLSYGFLTPPRLNRVSNHIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNG INVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECSALESSAYILPH RPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED >NP_445987.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rattus norvegicus] MERDGEQAGQGPRHGPAGNGRELESPAAASLLAPMDLGEEPLEKAERARTAKDPNTYKVLSLVLSVCVLT TILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKR LSRFVCSCADDCKAHNDCCINYSSVCQEKKSWVEEACETIDAPQCPAEFESPPTLLFSLDGFRAEYLHTW GGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSKEKFNP LWYKGQPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSYERPHFY TLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLN KYLGDVNNVKVVYGPAARLRPTEVPETYYSFNYEALAKNLSCRETNQHFRPYLKHFLPKRLHFAKNDRIE PLTFYLDPQWQLALNPSERKYCGSGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLG LIPAPNNESHGSLNHLLKKPIYTPSHPKEESFLSQCPIKSVSSDLGCTCDPSIVPIMDFEKQFNLTTDAV EDVYSMTVPNGRPRNLQKQHRVCLLHQQQFLTGYSLDLLMPLWTSYTFLSNDQFSTDDFSNCLYQDLRIP LSPMHKCSYYKSTSKLSYGFLTPPRLNRVSRQIYSEALLTSNIVPMYQSFQVIWQYLHDTVLRRYAQERN GVNVVSGPVFDFDYDGRYDSSEILKQNTRVIRSQENLIPTHFFIVLTSCKQLSESPLKCTALESSAFLLP HRPDNIESCTHGKQESAWVEELLALHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED >XP_004940275.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Gallus gallus] MQGNGEKAAGNGRQEGLGGRGAADGELQAAAVPMLPALEVAEEPEKAPGGKSKDPNTYKVLSLVLCVCVL TTILGCIFGLKPSCSKDVKTCKGRCFERTFGSCRCDRDCVKLGNCCLDYQETCIQPAHIWTCNKFRCGEK RRPEYHCSCSDDCVENNDCCVNYQAACKGEASWVEEECEDITEPQCPKGFKKSPVLLFSLDGFRAEYLQT WGGLLPVISKLQKCGTYTSSMRPVYPSKTFPNHYSIVTGLYPESHGIIDNKMYDLKRNAYFTLKSKEKFN PEWYQGQPIWLTAMYQGLKAGTFFWPGSDVAVDGTFPDLYKEYNGSIPFEERVVTVLRWLQLPEDERPHF YTLYLEEPDFSGHKFGPVSSGVILALQRVDTIVGMLMDGLKQMNLHKCLNIIFVSDHGMEAGSCRKTAYL NSYLDNVQDFIIVPGPAARLRPNNVPDEYFSFNYEGIVRNLTCVEPNQPFKAYMKQFLPKRFHYANNDRI EPLHFYLNSQWQLARKPLEIKSCTGGFHGSDNRFPSMQAIFIGFGPGFKFQTQVDPFENIEVYNLMCDLL DLKPAPNNGTHGRLNNLLRNPVYTPHHPKETSHPSECSFVGQRTFPVSPGCSCRTAGLPVRDFHQRLNLT ETEVKKIETLALPYGRPRVLQKKHNYCLLYHYRYVNGYSKDYKMSLWSAYTVNKNDNWISTTEDISSCLH KDVRIPSNHNQTCSFYNNHPRLTYGFLSPPNFMTDAKKSHYDSLLTSNIVPMYPAFKVLWSYFHQSLLPE YAADRNGVNVVSGPVFDYDSDGIYDTPEKVKRHPGNSEVPIPTHFFIVLTTCKNTSETPLKCEGSLDALS FIVPHREDNSESCADGRSESLWVEERMKFHIARVRDIELLTGLSFYQDRKQPISDILQLKTYLPTFETV >XP_016811798.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan troglodytes] MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAVRARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETC IEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERI LAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPY LKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIE ADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYMPKHPKEVHPLVQCPFTRNPRDNLGCSCNP LILPIEDFQTQFNLTAAEEKIIKHETLPYGRPRVLQKKNTICLLSQHQFMSGYSQDILMPLWTSYTVDRN DSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQ VIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSD ILKLKTHLPTFSQED >NP_001193141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Bos taurus] MERDSCAGGGSRGGEGGRGPREGLAGNGRDPGPGRAAEASGEPQAAASLLAPMDLGEEPLERAARARPAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDAACVDLGNCCLDYQETC IEPERIWTCTKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEKSWAEEECDSIDEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNNIY DPQMNANFALKNKEKFNPEWYKGEPIWLTAKYQGLKTGTFFWPGSDVKINGIFPDIYKIYNVSVPFEERI LAILKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYVYLNKYLGDTKDYKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFKPY LKHFLPKRLHFAKNDRIERLTFYLDPQWQLALNPSERKYCGGGFHGSDNTFLNMQALFIGYGPGFKHSTE VDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVRPLVQCPFTRAPRESLDCSCDP SILPIVDFQTQLNLTMAEEKTIKRGALPYGRPRVLQNSTVCLLYQHQFVSGYSRDILMPLWTSYTIGRND SFSTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGLLSPPQLHKGSSQVYSEALLTTNIVPMYQSFQV IWHYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRNLEVLIPTHFFLVLTSCKNT SQTPLQCENLDAMAFILPHKTDNSESCAHGKHESLWVEELLKLHTARITDVEHITGLSFYQERKEPISDI LKLKTHLPTFNQED >NP_001076211.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryctolagus cuniculus] MERDGCAGGGSQGGGKGGRGPREGLAGNGRDPSHGQASEAPGDPQAAASLLAPMDLGEEPLEKAAGARPA KDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQET CIEPERIWTCNKFRCGEKRLSRSLCACSDDCKERGDCCINYSAVCQGEKSWVEETCENINEPQCPEGFEM PPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYAKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKM YDPKMNASFSLKSKEKFNPEWYKGEPIWLTAKYQGLRSGTFFWPGSDVKINGIFPDIYKIYNGSVPFEER ILAILKWLRLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDNMVGMLMDGLKELNLHQCLNLI LISDHGMEQGSCKKYIYLNKYLGDTKNIKVIYGPAARLRPSDVPEKYYSFNYENIARNLSCREPNQHFKP YLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALSPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFQHGI EVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPIYTPKHPKEVQPSVQCPLAGSPRDSLGCSCN PSILPIVDFQTQFNLTTAEEKNINRASLPYGRPRLLQKKSSVCLLYQHQFVSGYSHDVLMPLWTSYTVNR NDSFSTEDFSNCLYQDLRISFSPIHNCSFYKNNAKLSYGFLSPPQLSKDSSQIYSEALLTSNIVPMYQSF QVIWRYFHDTLLQRYAEERNSINVVSGPVFDSDYDGRYDSSEALKRNRRVIRNQEILIPTHFFIVITSCK NTSQTPLQCDNLDPLAFILPHRSDNSESCVHEKRESSWIEELLMMHRARIMDVEHITGLSFYQERKEPVS DILKLKTHLPTVSQED >XP_020943592.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Sus scrofa] MERDGCAGGGSRGGEGGRGSREGPAGNGRDSGRGHGAEAPGEPQAAASLLAPMDLGEEQLEKAARARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETC IAPERIWTCSKFRCGEKRLSRSLCSCSDDCRDKGDCCINYSSVCRGEKSWVEETCESISEPQCPTGFEKP PVLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNANFALKTKEKFNPEWYKGEPIWLTAKYQGMKSGTFFWPGSDVKINGILPDLYKIYNGSVPFEERI LAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDDMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYVYLNKYLGDIKNVKVVYGPAARLRPSDVPDKYYSFNYEGIAKNLSCQEPNQHFKPY LKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGGGFHGSDNAFSNMQALFIGYGPGFKHSIE VDPFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVRSLVQCPFTRAPQENLDCSCDP SILPIVDFQTQLNLTMAEEKVIKRGTLPYGRPRVLQKNSTVCLLYQHQFVSGYSHDLLMPLWTSYTVDRN DSFSAEDFSNCLYQDLRIPLSPIHKCSFYKNNAKLSYGFLSPPQLNKGSSQVYSEALLTTNMVPMYQSFQ VIWHYLHGTLLQRYAEERNGINVVSGPVFDSDYDGRYDSLETLKQNSRTIRNQEILIPTHFFIVLTSCKN TSQIPSQCENLDTLAFILPHRTDNSESCAHGKHESSWVEELLRLHRARITDVEHITGLSFYQERKEPISD ILKLKTQLPPFNQED >XP_024104684.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pongo abelii] MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGHSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETC IEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEKSWVEEPCESVNEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERI LAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDSMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPY LKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPAERKYCGSGFHGSDNIFSNMQALFVGYGPGFRHGIE VDTFENIEVYNLMCDLLNLTPAPNNGTRGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNP SILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKKNTICLLSQHQFMSGYSRDILMPLWTSYTVDRN DSFSTEDFSNCLYQDFRISLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSRIYSEALLTTNVVPMYQSFQ VIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLEILRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCLHGKHESSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSD ILKLKTHLPTFSQED >XP_003638833.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Canis lupus familiaris] MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRC DVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCRDKGDCCVNYSSVCLGEKSWVE ETCESIDEPQCPAGFEMPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYS IVTGLYPESHGIIDNKIYDPKMNAFFALKSKEKFNPEWYKGEPIWLTTKYQGLKSGTFFWPGSDVEIKGI LPDIYKMYNGSIPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGM LMDGLKGLNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDVKDIKIVYGPAARLRPSDVPNKYFSFNYE DLAKNLSCREPNQHFKPYLKHFLPKRMHFAKNDRIEPLTFYLDPQWQLALNPSERKHCGSGFHGSDNLFS NMQALFIGYGPGFKHNIEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKNPKEVHPMV QCPFTRAPRHNLDCSCDPSVLPVTDFETQLNLTVAEEKVIKRGTLPYGRPRVIQKNTTVCLLYQHQFVSG YSHDILMPLWTSYTVDRNDSFSTEDFSNCLYQDLRIPLSPIHKCSFYKNNAELSYGFLYPPQLNKGSNQL YSEALLSTNIVPMYQSFQVIWHYFHGTLLQRYVEERNGVNVVSGPVFDSDYDGRYDSSETLRQNSRLIHN QEILIPTHFFIVLTNCKDTFQTPSQCDDLDSLAFILPHRADNSESCVHGKHESLWVEELLRLHRARITDV EHLTGLSFYQERRESISDILKLKTQLPAFDQED >XP_003827708.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan paniscus] MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAVRARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETC IEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERI LAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPY LKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNVFSNMQALFVGYGPGFKHGIE ADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYMPKHPKEVHPLVQCPFTRNPRDNLGCSCNP SILPIEDFQTQFNLTVAEEKIIKHETLPYGRPRVLQKKNTICLLSQHQFMSGYSQDILMPLWTSYTVDRN DSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQ VIWRYFHDTLLRKYVEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSD ILKLKTHLPTFSQED >XP_023110144.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Felis catus] MERGGCSGGGSSGGEGGRGSREGPAGNGHDPSHGRAAQAPGEGQAAASLLAPMDLGEEPLEKAAHARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETC IEPEHIWTCSKFRCGEKRLPRSLCSCSDDCRDKGDCCVNYSSVCRGEKSWVEETCENINEPKCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISRLKNCGTYTRNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKIY DPKMNAYFALKSKEKFNPEWYKGEPIWITAKYQGLKSGTFFWPGSDVEISGIFPDIYKIYNSSVPFEERI LAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHQCLNLIL VSDHGMEQGSCKKYVYLNKYLGDVKNIKIVYGPAARLRPSDVPDKYFSFNYEDLARNLSCREPNQHFKPY LKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPAESKHCGIGFHGSDNIFSNMQALFIGYGPGFKHSIE VDSFESIEVYNLMCDLLNLSPAPNNGTHGSLNHLLKHPVYTPTHPKEAHPLAQCPFTRTPRHNLDCSCDP SVLPVVDFEIQLNLTVAEEKVIKRGTVPYGRPRVLQRDSTVCLLYQHRFVSAYSHDILMPLWTSYTVDRN DSFSTEDFSNCLHQDLRISLNPVHKCSFYKNNAELSYGFLYPPQLNKGSSQLYSEALLNTNIVPMYQSFQ VIWHYFHGTLLHRYAEERNGVNVVSGPVFDSDYDGCYDSSETLKQNSRRIRNREILIPTHFFIVLTSCKN TFQTPSQCGDLDTLAFILPHRTDNSESCMHGKQDSSWVEELLKLHRARIADVEHITGLSFYQERKEPISD ILKLKTQLPTFNEED >XP_004011375.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Ovis aries] MERDGCAGGGSRSGEGGRSPREGLAGNGRDPGPGRAAEASGEPQAAASLLAPMDLGEEPLEKAARARPAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETC IEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEKSWAEEECDSIDEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPQMNAYFALKSKEKFNPEWYKGEPIWLTAKNQGLKTGTFFWPGSDVKIKGIFPDIYKIYNVSIPFEERI LAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYVYLNKYLGDTKDVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFRPY LKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNAFLNMQALFIGYGPGFKHSTE VDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLNNPVYTPKHPKEVRSLVQCPFTRAPRESLDCSCDP SILPVVDFQTQLNLTMAEEKTIRRGTLPYGRPRVLQNSTVCLLYQHQFVSGFSHDILMPLWTSYTIDRND SFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSSQVYSEALLTTNIVPMYQSFQV IWQYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSRIIRNQEVLIPTHFFIVLTSCKNT SQTPLQCEHLDTMAFILPHRTDNSESCAHGKRESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDI LKLKTHLPTFNQED >XP_018885608.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Gorilla gorilla gorilla] MERDGCAGGGSRGGEGGRAPREGPAGNGRDRGRSHAAEAPGDPQAAASLLAPMDVGEEPLEKAARARTAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETC IEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEKSWVEEPCESINEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPKMNASFSLKSKEKFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERI LAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYIYLNKYLGDVKNIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPY LKYFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNIFSNMQALFVGYGPGFKHGIE ADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVHPLVQCPFTRNPRDNLGCSCNP SILPIEDFQIQFNLTVAEEKIIKHETLPYGRPRVLQKKNTICLLSQHQFMSGYSQDILMPLWTSYTVDRN DSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSSGIYSEALLTTNIVPMYQSFQ VIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKD TSQTPLHCENLDTLAFILPHRTDNSESCVHGKHASSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSD ILKLKTHLPTFSQED >XP_023808792.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryzias latipes] MEETKAEESLPDQEATVFGTSEPEGQKKTSERRKTRIKHSKIIVGVLLLILLIAILAALISMKTKTHRGG GDLWLEQESHEVQQPTCPPGFSRPPLILVSLDGFRAQYLTDHQSHLRVIGALRNRGTTAPYIRPVYPTKT FPNHYTIVTGLYPESHGIVDNKMYDVTRNAFFSLKNEDEKCNPKWYQGEPIWITAIRQKLKAATYFWPGS DVAINGTFPNIFKEYDSGITFKTRVSTLLNWLSLPEEKRPDFYTLYLDEPDSSGHRYGPRSLEVIDALKN VDDMVGELMDGLTERNLHHCVNIIIISDHGMEEASCEKAAFVSNYLPHTSDFEVIQGPAARIRPKRLPED YFSFDYEGLVRNLSCSAHDLTMTPYLKEHLPKRMHFANNIRIERGHLYMKPGWQAALNQNEVKRCSGGFH GSDNIFTNMQGIFIGYGPGFLQNTIVPPFENIEVYNLMCDLLNIRPAPNNGTHGSLNHLLKNPVHHPVHP AQLSHETPCEAAEPAPTYSLHCNCSSQINSSETEMNRILLASSTKKESQRRVHHPYGTPGVVQSGANFCL LYHLDYINGYSKDRLMPLWVSYSIQPLLRPPKPRSETDVCVRADVRVPLASSQQCLQYKDDRSLTYGLLH PHYLSFSGPETDSLIGTNMVPMFPAFKKVWNYIHQSLLPKYSQQLNGINILSGPIFDTDYDGNVDPVREV SGNEASIPTHFFLILNSCQNLTLLPTNCVGPLKVQSFILPHRPDYSEVCKESDLEFVESWMSFHTARVRD IELLTGLSFYHSMISVEETLQLKTFLDTQRAIENS >XP_013224783.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Columba livia] MSPRSALKPPAELLLRLCGYRAGPMPRVRVSVGVRGEAWQARREAPSACGGARQPAGPAAAAAVPMLPAM EVAEEPEKAPRSKSKDPNTYKVLSLVLCVCMLTTILGCIFGLKPSCSKDVKTCKGRCFERTFGSCRCDKD CVKLGNCCLDYQETCIQPAHIWSCNKFRCGEKRRPEYHCSCSDDCVENQDCCVNYNTVCKGEASWVEEEC EDITEPQCPKGFTKSPVLLFSLDGFRAEYLQTWGGLLPVISKLRKCGTYTSSMRPVYPSKTFPNHYSIVT GLYPESHGIIDNKMYDPKRNASFTLRSEEKFNPQWYQGQPIWLTAMYQGLKAGTFFWPGSDVAVNGSFPN LYENYSSSIPFEERVMTVLRWLQLPEDKRPHFYTLYLEEPDSSGHRFGPVSSGVIVALQRVDNIVGMLMD GLKQMNLHKCLNIIFISDHGMEAGSCRKTAYLNSYLDDVQGFILVPGPAARLRPNNVPDEYFSFNYEGVV RNLTCIEPNQPFKAYMKHLLPKRFHYSYNDRIEPLHFYLESQWQLARKPLEIKTCIGGFHGSDNRFPSMQ AIFIGFGPGFKFRTRVDPFENIEVYNLMCDLLNLKPAPNNGTHGRLNHLLRNPVYTPHHPKEVSHPSECS VVGQRAFSVSPGCSCRTGGLPIRDFHQRLNLTETEVKKIEQLTLPYGRPRVLQKRHNYCLLYHDRYVSGY SKDYRMSLWSAYTVNKNDKWVSATEDTSSCLHKDIRIPFNHNQTCLFYNNHPHLTYGFLSPPNFMTDGRK PHYDALLTSNIVPMYPAFKVLWNYFHQYLLPEYAAARNGVNVVSGPVFDYDSDGLYDTPEKVKRHPSNSE VAVPTHFFIVLTSCKNTSETPLECEGSLDALSFVVPHREDNSESCADGKSESMWVEERMKFHTARIRDIE LLTGLSFYQDRKQPVSEILQLKTYLPTFETV >XP_017909005.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Capra hircus] MERDGCAGGGSRSGEGGRSPREGLAGNGRDPGAGRAAEASGEPQAAASLLAPMDLGEEPLEKAARARRAK DPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETC IEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEKSWAEEECDSIDEPQCPAGFETP PTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMY DPQMNAYFALKSKEKFNPEWYKGEPIWLTAKNQGLKTGTFFWPGSDVKIKGIFPDIYKIYNVSVPFEERI LAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLIL ISDHGMEQGSCKKYVYLNKYLGDTKDVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFRPY LKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSERKYCGSGFHGSDNAFLNMQALFIGYGPGFKHSTE VDSFENIEIYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVSSLGALVKGHWTRELTSLGCFG VITKDGNRKERYNNQFLTRLDFQKNEYLQFPGSLDFIWGCIILKIYFSEIVIKGNSYFFLKVSITIFYRN SRIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCEHLDTMAFILPHRTDNSESCAHRKRESLWVEELLELHR ARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_025068225.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator sinensis] MAVATFTALSQVRSPSAKVLCVCVLTVILGCIFGLKPSCTRDVKTCKGRCFERTFGSCRCDADCAKLGNC CLDFQETCIKPAQIWTCNKFRCGEKRRPEYHCSCSDDCVENDDCCFNYYAVCQGEKSWVEEKCENINESQ CPAGFTKPPLLLFSLDGFRVEYLRTWGGLLPAISKLQKCGTYTTSLRPVYPTKTFPNHYSIVTGLYPESH GIVDNKMYDPKRNVSFTLKSAEKFNPQWYQGEPIWLTAMYQGLKAGTYFWPGSDAKINGTFPNLYKIYNS SIPFEERVTTILQWLKLPEEERPHFYTLYLEEPDTSGHKFGPVSSEVILALQRVDRIIEMLMDGLKQMNL HKCLNIILVSDHGMEVASCRKTAYLSTYLDNVNNFMIVAGPAARLRPINVPDEYLSFDYEGIVRNLTCID SNQPFKAYMKWQLPKRFHFANNDRIEPVHFYLDSQWQLARKPFEIKSCKGGFHGSDNLFMNMQAIFIGFG PGFKFSTKVDPFGNIEIYNLMCDLLDLIPASNNGTHGSLNHLLKNPVYIPSHPEEASHPSSCSVMKQKPF PVDRGCICSSSGLPIRDFHQRLNLTASQEKNIEEYTLPYGKPRVLQKKSVSCLLYHHQYVSGYSKDLSMP LWSAYTISKSDTWIGSMENISSCLHTDIRTPSSHNQRCLFYKNHPQLNYGFLSPPNLIKDTKNSHYEALL SSNIVPMYPGFQVLWNYFYEVLLPKYVVARNGVNVISGPVFDYDYNGIYDVPEKVKRQPGNSEVLIPTHY YIVLTSCKNISQTPLECEGALDALSFIIPHREDNSESCASGKSASLWAEERMKFHTARIRDVELLTGLSF HQDRKQPVSDILQLKIYLPTFDKV >XP_006264801.3 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator mississippiensis] MAMRGDGGGKAAGERAAQPMLPAMEVAEEPDKARRRDPNPYKVLSLVLCVCVLTVILGCIFGLKPSCTRD VKTCKGRCFERTFGSCRCDADCAKLGNCCLDFQETCIEPAHIWTCNKFRCGEKRRPEYHCSCSDDCVEND DCCFNYYAVCQGEKSWVEEKCENINESQCPAGFTKPPLLLFSLDGFRAEYLHTWGGLLPAISKLQKCGTY TPSLRPVYPTKTFPNHYSIVTGLYPESHGIVDNKMYDPKRNASFTLKSAEKFNPQWYQGEPIWLTAMYQG LKAGTYFWPGSDAKINGTFPNLYKIYNGSIPFEERVTTILKWLKLPEEERPHFYTLYLEEPDTSGHKFGP VSSEVILALQRVDRIIEMLMDGLKQMNLHKCLNIILVSDHGMEVASCRKTAYLSTYLDNVNDFMIVAGPA ARLRPINVPDEYLSFDYEGIVRNLTCIDSNQPFKAYMKWQLPKRFHFANNDRIEPVNFYLDSQWQLARKP FEIKYCKGGFHGSDNLFMNMQAIFIGFGPGFKFSTKVDPFGNIEIYNLMCDLLDLIPASNNGTHGSLNHL LKNPVYIASHPEEAIHPSSCSVMKQKPFPVDRGCICSSSGLPVRDFHQRLNLTASQEKNIEEYTLPYGKP RVLQKKSVSCLLYHHQYVSGYSKDLSMPLWSAYTISKSDTWIGSMENISSCLHTDIRTPSSHNQRCLFYK NHPQLNYGFLSPPNLIKDTKNSHYEALLSSNIVPMYPGFQVLWNYFYEVLLPIYAVARNGVNVISGPVFD YDYNGIYDVPEKVKRQPGNSEVLIPTHYYIVLTSCKNISQTPLECEGALDALSFIIPHREDNSESCASGK SASLWAEERMKFHTARIRDVELLTGLSFHQDRKQPVSDILQLKIYLPTFDKV >XP_015802949.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Nothobranchius furzeri] MDGTKGEERSAEQAASLFGTSELENQRSDSERRKKRICKIISGILLLFLLIALLAVVISVKLGDKEKETD SAFEEVHQRQCPPGFPRSPLILVSLDGFRAKYLNDHKSHLPVLNKLRSAGTTAPYIRPVYPTKTFPNHYS IVTGLYPESHGIIDNKMYDVTQNAFFSLKTNEKFNPRWYHGEPVWLTAMRQKLRTATFFWPGSDVPINGT FPDFYKQYDSQIPFEQRLATLFGWLSLPKEQRADFYTLYVDEPDTAGHKYGPESQQVISALEKVDKLLGM LMNGLKERRLHRCANVIIMSDHGMEEASCDRATFVTNYQQHTSDFIIIQGPAARIRPKRLPDDYFSFDYE GLVKNLSCRTPEQPMRPYLKENLPKRMHFANNQRIERGHLYMKSGWQAALNQQEVKYCTGGFHGSDNVFD NMQAIFIGYGPAFKTNTVVAPFENIEIYNLMCDLLEISPASNNGTHGSLNHLLKDPYYKPVHRAPLSLDT PCETSDPNPAPTSLLQCRCASQTVEMEKQMNTVLLAINDETKASLRRLHHPFGTPQIIQPDASFCLLYQS DYLTGYSRDIIMPLWVSYVIQPLVHVRAPSPEECVRADVRVPPSAGQLCSRFKNHPRLTFGLLHPPYLNS SAPETDSLINSNMVPMFPAFKNVWTYFHNSLLVKYSQILNGINIISGPIFDTNFDGHADKFNKILGNEAD VPTHFFLILTSCRNSTFSPVECKGPLQVSAYILPHRPDYSEVCTEGSDYSFVEKWMSFHTARVRDIELLT GLSFYHDRLSVEETLQLKTFLHT >XP_020738141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Odocoileus virginianus texanus] MSSSTLTDAKDPAKVEGGERMIVIYSLILVLGTVSLAQSRRPNIRTRDTLSVLITRNWEQEKKKGRFPPP RCALSPLCLSIPKRRGPSRLHSPAFEKPHRRAASSPSTRSILGPHDLMPSADHTLQFQTSPRREATQVSG RCPRREVGKAWRGRLKTRPRGGPKITDTLSARNQTGSQIIRGVELLSPHSQRRAAGAQPRVWRRGAAEAS GEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKG RCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNH GSVCRGEKSWAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNLRP VYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSKEKFNPEWYKGEPIWLTAKHQGLKTGTF FWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVI RALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKDVKVVYGPAARLRPS DVPDKYYSFDYEDIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSERKYC GSGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENVEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVY TPKHPKEVRSLVQCPFPRAPRESLDCSCDPSILPIVDFQTQLNLTMAEEKAIKRGALPYGRPRVLQNSTV CLLYQHQFVSGYSHDILMPLWTSYTIDRNDSFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLS PPQLHKGSSQVYSEALLTTNIVPMYQSFQVIWHYLHGTLLQKYAEERNGLNVVSGPVFDSDYDGRYDSLE TLKQNSKIIRKQEVLIPTHFFIVLTSCKNTSQTPLQCENLDPLAFILPHRTDNSESCAHGQHESLWVEEL LKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_030261662.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Sparus aurata] MDSAKGEQRSAEQAASLFGASEMESQGRQADRGKKRNNCKIITGVLLLCLLVLILTVALSLRKSKDESGG QIWLNEADVEIQQPKCPPSFSRPPLILVSLDGFRAEYLKDHSSHLPVINKLRNTGTTTPYMRPVYPTKTF PNHYSIVTGLYPESHGIVDNKMYDVTQDAFFSLKTDEKLNPKWYQGEPVWITAMRQKLKTGTFFWPGSDV AINGTHPDYYMVYDKSITFEKRVSKLFEWLKLPQGQRPDFYTLYLDEPDSSGHRYGPASTQVVEALENVD RILGTLMDGLTQRNLQHCVNLIIVSDHGMEEASCEKALYVSSYIDNTADFSVIQGPAARIRPSRLPENFF SFDYEGLVKNLSCRTSDQPMRPYLKENLPKRMHFANNKRIERGHLYMKSGWQAALNRKELKYCTGGYHGS DNLFTNMQAIFIGYGPGFKESTVVPPFENIEVYNLMCDLLDIRPSPNNGTHGSLNHLLKRPVYLPVHPAQ LSHETPCKAVGPVPNDDLQCTCSSLNTTMVTFMNRHLMNTNSSVKASLRRLHHPFGTPRVVQPDASFCLL HHSSYLSGYSKDRLMPLWVSYTIQPLTRVQPLSPESEACVRADIRIPPAASQLCLRYRDDPALSYGLLHP PNLSVNGPETDSLLTSNMAPMFPAFKDVWVHVHNVLLPKYSQQMNGVNIMSGPIFDGDYDGNVDALKAIS GNEAPIPSHFFIILTSCGNSTFSPVDCEGPLQAKSFILPHRPDHTESCADGSDLTWVEEWLQFHSGRVRD IELLTGLSFYHDRISVEETLQLKTHLQSA >XP_040206375.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rana temporaria] MDCEARNGGTGTEIQAEPMLNSLDMAEEPVKAAQRKKKKSGNWKVLSLVICVVILTAILGCIFGLKPSCS REVNSCKNRCFERKFGSCRCDTACVELGNCCLDYKDLCIQPAHIWTCDKLRCGEKRLPSSLCSCSDDCKD TNDCCVNYDSVCRGNKSWVEEENCDEMQTPICPAGFSQPPVILFSLDGFRAEYFHTWNGLLPVISKLKKC GTYTRALRPVYPSKTFPNHYSIVTGLYPESHGVVDNKMYDPYRNAFFTLRSSEKFHSSWYQGEPVWITAM NQGLKAATYFWPGSDVKINGTFPNIYKEYNGSIPFENRVISVLKWLRLPENVRPHFYTLYLEEPDSSGHK HSPMSSAVIKALMEVDQIVGMLMDGLKQMQLDKCVNILLLSDHGMEESRCENIAYLGSYLNTSEEYIVIH GPAARLRPNRLPDEYFSFDYADIAKNLTCRKKNQHFKPFLKKDLPKRLHFANNDRIESLHFYSDPKWQVA KSQSEVSKFCNGGFHGSDNLFKNMQALFIAYGPKFKYNTEVQPFENIEIYNLMCDLLGIEPAANNGSHGS LNHLLKKPVYEPSLPKELSEPFQCSVNHSALGNAFGCSCNLPSLTEAAFKAHLILTPEQESDTKRLNLPF GRPVVLQNSNYCILYQDKYVSGYSYNIKMPLWSSYTIGKNEFVSASLDKNSLCLFMDARVPPGQSQRCQY YHHHPSLKFGFFFPASLRKTSESTSYSGLTTSNIGPMYPAFKVIWDYFQNVILLKYASEKNGVNVISGPI FDYDFDGQSDGFEQIQQMSKDTDVYIPTHYYIILTSCKNSSESLLLCTGPLDVISYVVPHRTENSESCAD DKDESLWVEQLLRFHAARVRDVELLAALSFFHNTKYSVSELLQFKTFIPDYL
Mafft alignment of selected proteins >NP_006199.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Homo sapiens] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRA-----PRE--GPAGNG----------------------RDRGRSHAAEA PGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCG ---EKRLTRSLCACSDDCKDKGDCCINYSSVCQGE----KSW-VEEPCESINEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-VTAKYQGL--KSGTF FWPGSDVEINGIFPDIYK-MYNGS----VPFEERILAVLQWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY IYLNKYLGDVKN----IKVIYGPA---ARLRP-----SDVPDKYYSFNYEGIARNLSCRE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNVFSNMQALFVGYGPGFKHGIEA-DTFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYTPKHPKEVHPLVQCPFT---RNPRDNLGCSCNPSILPIEDF------ --QTQFNL--TVAEEKIIKHETLPYGRPRVLQKENTICLLSQ---HQFMSGYSQDILMPL WTSYTVDRNDSF--STEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNS SGIYSEALLTTNI---VPMYQSFQV-IWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDG RCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTS--QTPLHC--EN-LDTLAFILPH RTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKE---PVSDILKLKTH LPTFSQED-- >CAE1329719.1 ENPP1_3 [Sepia pharaonis] -M-----------------LRFY------------------------------------- ------------------------------------------------------------ -------------------------------LS--------------ISFRVFFKRNLKI R---ASPSSAA----FPRI--STAEIT---------------------------NGITGA CVWKELGN-LVREYTVKYTTLNVISGPIFKDGLDNAKRLHSVNCSVPIPTHFYVILSKLS SADMSI---------------------PAEVLPIILPHVEKDQNCLKPKDYFFDHTARIR ---DIELLTGLTFMTDIPWEKSIKIRTYLPLEMWESLRPSSWMKLQHCVNLDK---ACKN ASRPVLLISLDGFRADYTNY--EVTPVINRLRECGIQTSFMRSSFPSKTFPNHYTIATGL YPESHGIVGNYMYDMEKNDVFKMST-T----DPYWW--GGETIW-KTLSKAGK--ESGSY FFVGS--SISGVNATYFY-PYSGK----TSYEDRIDQAVAWIR----QGLPFVSIYFEEP DSTGHREGPSSKQ-ILNTLRLVDSYIGQLMNKLYEENMHNCVNIIIVADHGMTDVNCERS VVLWDIIDKETATKDMFVYSDGRV--TNKYWQEGKTFKRFSNGSYAITVPELTSKLECSS --RHMKVFQKEFLPKRLHYTKHKRIGDIQLLINDTWYLQRKNL-----YCGGR------- ---GSHGYDNRFKSMNALFLAYGPDFKQQLHT-EPFQNIEIYNLFTDLLNIPGA-PNNGT EGRLHRLLRRP------PPETLRQSV------GQYKNVSFNMNFDDLALFLKKHRCLNFT PTNKEVSLIYTSMVNSNKKFQEISFGLP-LLKNNVSIQMLKH---KAYLTAYDTNRKRLL FIAATRKSSQPFANFSDAGNGCI-VDPRVHFDQMK---YDQTENNYTWLNLTPADFADDE EK--ITSFLSTNF---IRVAKAFKEDLWIEALN-VVQKWRTSFSMFTWFVGPIYDYNLDG LADDDDTIK---RF---TNESLPTNVFFVLVGCQNTG--EIEA---------TTAYILPS NQQHFPKCRK-------MSQMLRDHQARVRDVELLTNLEFYPKEPFQKAVIHRTSMIDVK LPLKD----- >XP_031562620.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like isoform X3 [Actinia tenebrosa] -M-----------------KQ--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------AIKSIIILTLLILLLCNSL GAKIN------------------------------------------------------- ------------------------------------------------------------ SKSTVLLISFDGFRWDYMDK--TETPNFDSIVKTGVKAKYVKNAFVTKTFPNHFTIVTGL YEESHGIVANTMYDPEFKSWFYLNN-T----EPRWW-NGGEPVW-ITNQNSGG--TSGTV FWPGSNVEIRGQYPTYYL-KYDHN----LXYRDRVDKVVDLLTK--KXPPTLLTLYFEEP DHSGHTYGPESKE-VVKAIRTADNVTGYLINHLKAKGLFDKINIIITSDHGMTEISVNNT VYLQDYVPSEWY----VPITAKEWDSFTLIKP-----KNG-------YKENIYNRLKNV- --SHIKVYKKEAIPMEYHYTNNRRIMPILVVGEEGWSVALSRKVK---FKDK-------- ---GNHGYSNKYESMHPFFIAHGPAFKSGYLS-EPFKNVDIYPLMCHILGIKPA-XNNGS LADVQQLLRNEIQ-TVAFFTISPM------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------ITTKKKMRV------------------------------------------- ------------------------------------------------------AFIV-- ------------------------------------------------------------ ---------- >XP_039259773.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like [Styela clava] -M-----------------GR--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------NPQIFVKTFLYAILIIFQ LAVCE------------------------------------------------------- ------------------------------------------------------------ HTPKLLLISFDGFRWDYLSK--TDTPNFDRITNNGVRAKWIKDSFTSLTFPNHYTIATGL YEESHGIVANIFYDPVFNETFQIGN-ETTVLDGKFW--GGEPIW-VTNQLQGG--RTGVY YWPGSEAEIKGVRPNIYE-KYIQQEVSMALWRNRTDTVIEWLTDPE-NVVDLALLYFKEP DHTGHIYGPESPE-VVQMIQQCDNITGYILDQIEEHGLSNLLNIIITSDHGMTGMNRSRF ITLDDHIDTHQT----KHLINYIV--GTSVWP-----KSG-----ENITEELYKNLSSID P-EHVQVWMKKDIPPEYHYANNRRIAPILMSANEGWGIKENWND-TH-YLL--------- ---GRHGFNNSKMDMHPFFVATGPVFKKGFIS-EPFENVNIYSLMCHILGINPA-PNNGS LDAVKQLLADEYI-PDEEYKYTQL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------QFTIAKWAGICFGAIIVI-VL-------------------------------- -----------------------------------------------------LIYVI-- -------------------KELKMNSQMRKEVSGFSNSNLKYSER----DENREPLLSTD FP-------- >XP_797859.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [Strongylocentrotus purpuratus] -M-----------------LS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------ALSFFLAVAVVITIGDTS AATGN------------------------------------------------------- --------------------------------------------------------DNGD DQELLLLVVFDGFRYDYLEK--TATPNFDRLVNMGAKPAGMTPAFATKTFPGHHTIATGL YQENHGIIGNNMYDPEFNSTFGQAN-N----EPRWWNYGGEPIW-VTNQINGG--RTVSV FWPGDRVNISGMTATYHQPAYDGS----FPNEDRIDLVVGLMSN---GSANLGILYFSEP DNTGHLQGPESNE-TANSIADCDETLGYLLEKLTEADLLDDVNIIVTSDHGMASVSPDQT VFLDDYVDRSLY----FYTNNDPV---FGLWP-----YD------ENSTEELYDALKDAH --PNMDVYLKAEIPEEYHYRDNRRTSPILVVMEEGWHVWTNSSIEGNWQRYK-------- ---GNHGFLNTLESMRSIFIASGPAFKSNYASNDLLDAVDVYNLMCHLLAVDPA-PNNGT FSHVEPLLANEGTGTSPETAETTL------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------QMTTEGSGGRIAYSAHLLS-LV-------------------------------- -------------------------FAIFL------------------------AFYF-- ------------------------------------------------------------ ---------- >NP_001129885.1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans] -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------VVIVVIVLLLTQLKAANS NAQNAM-SSSKVQLEELTR----------------KLSQPLEQLGPTLERLSNMPGFPMG PSPTTQTPPGVPPISPIVTGPNTTPESPRRSPKAR----YEW---KGCQNLGKCE-LSGY TKPPLVILSLDGFAREYVDR--NIVQTLNHIADCGVKADKVYPSYPSKTFPNHYSIVTGL WPESHGITDNSVFDPTISPVLESMK-STK--YEKFF--EGEPIWSVYKRKTGK--KANCL FWVGCAYNNSGYAPDVAP-AYNQE----LPFRNRIDTVVEWLKLPVDERPGLITAYLHEP DNAGH-YQVDEED-VDEKLAEIDENLDYLMSRLSEEKLLECINFAILSDHGMQLI--DKT YYFQDYLDL-KG----LITAKGVV---GRVYI-----NDT-----TISVNDVVDKFRCKI --DTVKTNTRSDVPTRKHYSRDPRVGEVLLEGRAGVTFYKSKADD---YELS-------- ---GDHGYDYFNPKMHTIFYARGPSFKQNTTI-SPYQNIQYMNLWMNLLGIEGAVETNGT IGFFDNILTNP---PRRDNPTNVIGECPMI----AFPSVLKCSGNVSAETLNQL------ ----------------SVKLTNCAFSPTNIPLYSDNHCFQNYCDNSVIVSRKGNDARRAI IEVLSRDEASN------------------PSNFTFLNAKYQSN--------CPSHIPTGS LTIRQNSQLSSMVDERIDVPNNFLLKVLDPLQA-KSMEYLNKFGKMYVISGTATDINHDG IAD--------------SNGSVITHIYRIMLICNSTWLLMNPPLCTDSDSMDTLSFIFPI TEQSTIDCMS-------SDDILLDYTATIFDVERISGFQFGIGAL----SQNQNTIIRRK ISTKLW---- >XP_038076960.1 bis(5'-adenosyl)-triphosphatase enpp4-like [Patiria miniata] -M-----------------AAWW------------------------------------- ------------------------------------------------------------ -------------------------------W---------------------------- ------------------------------------------------------------ ---------------------------------------KLGPVNVLLCSFLLTVFSASP YYKQA------------------------------------------------------- --------------------------------------------------------PSTS DAPLVLLVSFDGFRWDYLDR--NKTPSFDSFVRDGVKAKYLFDTFASKTFPNHYTIATGL YQESHGIVGNNMYNVSTGAKFTLRH-K---FNSSWW-EGGEPIW-VTNQNQGG--HSGLI MYPGMEIQIRGQYPSYRLPKYNST----FPYEERINIMTRLFAN---GSINLGLLYFREP DHSGHMLGPNSPD-MDAVIQMCDETLGYLMKKLRDAGLGDRVDVIVTSDHGMTPVSKDNF TQLDDFVDPELY----YYTDNNPV---IGIWP-----HK------ESDVDVIYNKLQGAS --PHVSVYLKDEIPAQYHYRDNPRIAPILLVAKEGWAIHVGNKTGSHFLNYK-------- ---GNHGFNNSLMSMHPIFVARGPSFRQGLLV-EPFENVNIYPLICKILGLEPA-PNNGS LENVQDLLKYSELVTIMTTNEKGIIT---------------------------------- ------------------------------------------------------------ ---------------------------------------------------EPP------ -----PSTWSTGTVIGIAVAGAILL-VA-------------------------------- -------------------------ACLLLAMCARQ------------------------ ----------------------RSYRQQPREYTPIADTSLEGVD-----EIADSGFSSYN YPNTKI---- >XP_006560637.2 bis(5'-adenosyl)-triphosphatase enpp4 isoform X1 [Apis mellifera] -M---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------NSVIIFALTLVILFNVKY GLLIS------------------------------------------------------- ------------------------------------------------------------ QHPKLLVVSFDAFRYDYFNR--NLTPFMNKLRHEGTHADYMMNIFVTKTFPNHHTMATGL YAETHGVIDNEYYDVISGNTTKYSY------NLYHYDNKVLPIW-TANEKGGAQRRSGSM MWPGGIYEYQGITPTFTQ-NFNEN----IPWEERIDTLISWFIHPI-HPINFGILYIEEP DYHGHGIGIKGLE-FDNILRKLDNITKYLHNKIEYHGLND-LNVVHLSDHGMATVKLDRI IDLTKYINSSDY----KFVGTSPG---LHIFP-----NPGKEETIYQTLKQIASKL---- --KKFRVYRREEIPKKYHYGNNTRIGPIFVIAEVGYAFQNLLDN-IEFYKKKFNITVNND SEFGLHGYDNEAIEMHPFFFAKGPAFMSNCKL-EPFNNLDLYPLFCKILDLQCP-IVNGT LLHLTKCLKKH------QQDITVIAYRMIF------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----IATIISMSM---VGVIGAIVM-FYMRKRRLGVRSYRRILEDLEA------QYHWDE NHDI-----------ENATCKLKNFPDLFIISCYAKN----------------------- -------------------KHLYAYKGNVKYRKTLFHCR--------------------- ---------- >XP_043313008.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Cervus canadensis] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRG-----PRE--GLAGNG----------------------RDPGSGRAAEA SGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAHFALKS-KEK-FNPEWY--KGEPIW-LTAKHQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRSLGQCPFP---RAPRESLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKTIKRGALPYGRPRVLR-NSTVCLLYQ---HQFVSGYSQDIVMPL WTSYTIDRNDSF--FTEDFSNCFYQDLRIPVSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWNYLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EN-LDPLAFILPH RTDNRESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >KAB0379402.1 hypothetical protein FD755_007186 [Muntiacus reevesi] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRG-----PRE--GLAGNG----------------------RDPGSGRAAEA SGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL------------------- -------------------------------------------------RIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAHFALKS-KEK-FNPEWY--KGEPIW-LTAKHQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRSLVQCPFA---RAPRESLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKTIRRGALPYGRPRVLR-NSSVCLLYQ---HQFVSGYSHDILMPL WTSYTIDRNDSF--FTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWNFLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EN-LDPLAFILPH RTDNSESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >KAB0356465.1 hypothetical protein FD754_000621 [Muntiacus muntjak] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRG-----PRE--GLAGNG----------------------RDPGSGSAAEA SGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL------------------- -------------------------------------------------RIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAHFALKS-KEK-FNPEWY--KGEPIW-LTAKHQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRSLVQCPFA---RAPRESLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKTIRRGALPYGRPRVLR-NSSVCLLYQ---HQFVSGYSHDILMPL WTSYTIDRNDSF--FTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWNFLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EN-LDPLAFILPH RTDNSESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >XP_018118655.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Xenopus laevis] MM-----------------SKQM------------------------------------- -----------DCS---LCL-------------------------------------FTP SSE----------------------------WRAER-----------MGLSGWRQERESS S-NCTESDIRA----AAREAGGTAVNGSKACGTDTEQQQQQLGWWGKDIRDMESGGRNGS TGGETLEQSMLNPMTLVEDPGRGSHSAK-KKKSNKWKVLSLVICVCLLTAILGCIFGLKP SCTREV-TSCKGRCFERKF---GSCRCDSACVELGNCCLDYQDVCIQPAYIWTCEKLRCG ---EKRLTGSLCSCSDDCSEIQDCCVNYNAVCRGN----KSW-SEETCEEIQTPQCPSGF SKPPLLLFSLDGFRSEYLHTWGELLPVISKLRKCGTYTTNLRPVYPSKTFPNHYSIVTGL YPESHGLVDNKMYDPKRNAFFTLRN-TEK-FHPSWY--QGEPIW-ITAMNQGL--KAATF FWPGSDVKIKGTYPNIYK-MYNST----VKFEERVMSILRWLRLPEQERPHFYTLYLEEP DHSGHGHGPVSSA-VIKALMGVDRIVGMLMDGLKQMQLDKCINLILASDHGMEEARCENV AFLSSFLEPSDS----FIVIPGPA---ARLRP-----TKLPDEYFSFDYTGIAKKLTCRE PNQHFKAYFKQNLPKRFHFAKNDRIELLNFYTDPKWQVAKTKSD-AK-TCVG-------- ---GFHGSDNRFESMQALFIGFGPGFKFKTEV-EPFENIEIYNLMCDLLGITSA-TNNGT HGSLNHLLKNPVYMPSLPHEISDPFQCSVI--HGANTDSLGCSCDSTNLTVFGS------ --EQPMTL--TPQQESETKKQNLPFGRPVVVQ-NSSYCILYH---EQYVSGYSYHISMPL WTSYTVGKHAH---SVDSGSSCIFADVRIPSNHSQSCHHYQKHYFLKYGFLYPPGLKESS GD-SYAGLLTSNI---VPMYPAFQV-IWNHFHNVLLMKYADKKNGVHVISGPIFDSDFDG QFDTLEQIN---KITEDATVYIPTHYYIVLTSCKNAS--QTLQQC--AGALDVLSFIVPH RIDNSESCASGKNESLWVEKLLHFHAARVKDVELLTGLSFFHNSKY---SVNEILQLKTF LPSSM----- >KAF4024570.1 hypothetical protein G4228_016567 [Cervus hanglu yarkandensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAYFALKS-KEK-FNPEWY--KGEPIW-LTAKHQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKD----VKVVYGPA---ARLRP-----SDVPDKYYS------CKSISCQE PNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRSLGQCPFP---RAPRESLDCSCDPS------------- ------------------------------------------------------------ ---------DSF--FTEDFSNCFYQDLRIPVSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWNYLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EN-LDPLAFILPH RTDNRESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >XP_010707567.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X6 [Meleagris gallopavo] MM-----------------KS--------------------------------------- -----------------------------------------------------------P P----------------------------------------------------------- ------------------------------------------------------GQITRA CQPHQVISLFAFAFGVNVCMGFTTNRFRRSEEWDEGPI---------------SVLSDSP WISTS--GSCKNRCFELQEAEPPGCRCDNLCKSYNSCCFDFDELCLKTARGWECTKDRCG ---ETRNDDNACHCSEDCLSRGDCCTNYQVVCKGE----THW-VDDDCEEIKTPECPAGF VRPPLIIFSVDGFRASYMKKGNKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGL YPESHGIVGNSMYDPVFDASFSLRG-REK-FNHRWW--GGQPIW-ITAAKQGV--KAGTF FW-------------------SVV----IPHERRILTILQWLTLPDNERPYVYAFYSEQP DAAGHRYGPFNSEMMVNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDTTCERT EFLSNYLTNVED----IILLPGSL---GRIRP-----RS--SNNLKYDPKVIVANLTCRK PDQHFKPYLKHHLPKRLHYAYNRRIEDVHLLVDRKWHVARKAVDVYK-KPTG--KCFFH- ---GDHGYDNKINSMQTVFIGYGPTFKYKTKV-PPFENIELYNVMCDLLGLKPA-PNNGT HGSLNHLLRANVYKPTVPDEVAKPLYPVAL--PSASDFDIGCTCDDKKNKLDEL------ --NKRFHV--KGTEEK-----HLLYGRPAVLY-RTKYNILHH---HDFESGYSETFLMPL WTSYTISKQAEVSGVPEHLASCVRPDLRISPGNSQSCSAYRGDKQLSYGFLFPPQLSSSA EA-KYDAFLITNI---IPMYPAFKK-VWNYFQRVLVKRYATERNGVNVISGPIFDYDYDG LHDTPEKIK---QFVEGSAIPVPTHYYAIITSCLDFT--QPADKC--DGPLSVLSYILPH RPDNDESCNSLEDESKWVEDLLKMHTARVRDIEQLTSLDFFRKTSR---SYTEILSLKTY LHTFESEI-- >tr|B0JZL7|B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=enpp1 PE=1 SV=1 -M-----------------DS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A KRDEHMSEHAANLLGTGQRYTRTHNTAKVQSR--YLKILCAVLLLGLLALILTIIFLLKL RCSDKVIDSCKNRCISKSHDGNAGCRCDAACVNEGTCCLDYEEVCLQPTQLWTCSKFRCG ---EDRLPSSLCSCSADCVKVGDCCANYKRTCEGE----KSW-LQEDCEDIRTPQCPAGF SKSPLLLVSLDGFRAGYMNAYSALLPAIRKLRECGTSTPYMRPAYPTKTFPNHYTIVTGL YPETHGIVDNKMYDVNRNASFSLKV-DEK-FNPLWY--QGEPVW-ITAMKNHL--KTATF FWPGSDVKVHGRYPDYWI-KYNRN----ILFEKRIAQIFQWLHLPEGERPDFYTLYFEEP DASGHKYGPMSTQ-VIEALINVDRLIGMLMDGLKERNLHKCVNVVLVSDHGMEEASCKKA AYVSNYLDNIND----ITVIQGPA---ARVRP-----RHVPEEFFSFDYEGLVKNLSCRE PNQPMKPYLKEHLPKRLHFAKNIRIERAHLYMQPQWQAALKPSE-IK-YCRG-------- ---GFHGSDNVFKNMQAIFIGYGPGIHYNTTV-PPFENIEVYNLLCDLLGISPA-ANNGT HGSLNHILKKPRYQPVFPAERSAPSTCSAV--SSSLRDPRGCTCDSLTEAEVNR------ --LNQRLI--NSNSDSNVKPVHLPFGIPRVLQDQSDYCILHH---SSYISGYSRDILMPL WVSYSLNTTVV---LHPSAEWCVRADVRVQASDRQSCSIYKNNSSMSFGLLHPPNFSPAG TE--PDSLITSNM---VPMYPGFKD-IWTHFHNFLLIKFSEEMNGINVVSGPIFDNDFDG NYDFMNKG-------VLNGAPIPTHFFIILTSCKNSS--LSVRQC--EGPLDAVSFILPH RPDHLETCHNGTDYS-WFQDWVQLHVARIRDIELLTGLSFYHDRI----SVAETLQLKTR LKTF------ >NP_032839.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 2 [Mus musculus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------D------------ ----GDQAGHG-----PRH--GSAGNG----------------------REL-------- --ESPAAASLLAPMDLGEEPLEKAERARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---SNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCG ---EKRLSRFVCSCADDCKTHNDCCINYSSVCQDK----KSW-VEETCESIDTPECPAEF ESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPLWY--KGQPIW-VTANHQEV--KSGTY FWPGSDVEIDGILPDIYK-VYNGS----VPFEERILAVLEWLQLPSHERPHFYTLYLEEP DSSGHSHGPVSSE-VIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKY VYLNKYLGDVNN----VKVVYGPA---ARLRP-----TDVPETYYSFNYEALAKNLSCRE PNQHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNLFSNMQALFIGYGPAFKHGAEV-DSFENIEVYNLMCDLLGLIPA-PNNGS HGSLNHLLKKPIYNPSHPKEEGFLSQCPI----KSTSNDLGCTCDPWIVPIKDF------ --EKQLNL--TT-EDDDIYHMTVPYGRPRILLKQHRVCLLQQ---QQFLTGYSLDLLMPL WASYTFLSNDQF--SRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNRVS NHIYSEALLTSNI---VPMYQSFQV-IWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDG RYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLS--ETPLEC--SA-LESSAYILPH RPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQE---SVSELLRLKTH LPIFSQED-- >NP_445987.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rattus norvegicus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------D------------ ----GEQAGQG-----PRH--GPAGNG----------------------REL-------- --ESPAAASLLAPMDLGEEPLEKAERARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---SNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCG ---EKRLSRFVCSCADDCKAHNDCCINYSSVCQEK----KSW-VEEACETIDAPQCPAEF ESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPLWY--KGQPIW-VTANHQEV--RSGTY FWPGSDVEIDGILPDIYK-VYNGS----VPFEERILAVLEWLQLPSYERPHFYTLYLEEP DSSGHSHGPVSSE-VIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKY VYLNKYLGDVNN----VKVVYGPA---ARLRP-----TEVPETYYSFNYEALAKNLSCRE TNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNLFSNMQALFIGYGPAFKHGAEV-DSFENIEVYNLMCDLLGLIPA-PNNES HGSLNHLLKKPIYTPSHPKEESFLSQCPI----KSVSSDLGCTCDPSIVPIMDF------ --EKQFNL--TTDAVEDVYSMTVPNGRPRNLQKQHRVCLLHQ---QQFLTGYSLDLLMPL WTSYTFLSNDQF--STDDFSNCLYQDLRIPLSPMHKCSYYKSTSKLSYGFLTPPRLNRVS RQIYSEALLTSNI---VPMYQSFQV-IWQYLHDTVLRRYAQERNGVNVVSGPVFDFDYDG RYDSSEILKQNTRVIRSQENLIPTHFFIVLTSCKQLS--ESPLKC--TA-LESSAFLLPH RPDNIESCTHGKQESAWVEELLALHRARVTDVELITGLSFYQDRQE---SVSELLRLKTH LPIFSQED-- >XP_004940275.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Gallus gallus] -M-----------------QG--------------------------------------- ------------------------------------------------------------ -----------------------------------------------NGEKA-------- -------AGNG-----RQE-----GLG---------------------------GRGAAD GELQAAAVPMLPALEVAEEP-EKAPGGK-SKDPNTYKVLSLVLCVCVLTTILGCIFGLKP SCSKDV-KTCKGRCFERTF---GSCRCDRDCVKLGNCCLDYQETCIQPAHIWTCNKFRCG ---EKRRPEYHCSCSDDCVENNDCCVNYQAACKGE----ASW-VEEECEDITEPQCPKGF KKSPVLLFSLDGFRAEYLQTWGGLLPVISKLQKCGTYTSSMRPVYPSKTFPNHYSIVTGL YPESHGIIDNKMYDLKRNAYFTLKS-KEK-FNPEWY--QGQPIW-LTAMYQGL--KAGTF FWPGSDVAVDGTFPDLYK-EYNGS----IPFEERVVTVLRWLQLPEDERPHFYTLYLEEP DFSGHKFGPVSSG-VILALQRVDTIVGMLMDGLKQMNLHKCLNIIFVSDHGMEAGSCRKT AYLNSYLDNVQD----FIIVPGPA---ARLRP-----NNVPDEYFSFNYEGIVRNLTCVE PNQPFKAYMKQFLPKRFHYANNDRIEPLHFYLNSQWQLARKPLE-IK-SCTG-------- ---GFHGSDNRFPSMQAIFIGFGPGFKFQTQV-DPFENIEVYNLMCDLLDLKPA-PNNGT HGRLNNLLRNPVYTPHHPKETSHPSECSFVG-QRTFPVSPGCSCRTAGLPVRDF------ --HQRLNL--TETEVKKIETLALPYGRPRVLQKKHNYCLLYH---YRYVNGYSKDYKMSL WSAYTVNKNDNWISTTEDISSCLHKDVRIPSNHNQTCSFYNNHPRLTYGFLSPPNFMTDA KKSHYDSLLTSNI---VPMYPAFKV-LWSYFHQSLLPEYAADRNGVNVVSGPVFDYDSDG IYDTPEKVK---RHPGNSEVPIPTHFFIVLTTCKNTS--ETPLKC--EGSLDALSFIVPH REDNSESCADGRSESLWVEERMKFHIARVRDIELLTGLSFYQDRKQ---PISDILQLKTY LPTFETV--- >XP_016811798.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan troglodytes] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRA-----PRE--GPAGNG----------------------RDRGRSHAAEA PGDPQAAASLLAPMDVGEEPLEKAVRARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCG ---EKRLTRSLCACSDDCKDQGDCCINYSSVCQGE----KSW-VEEPCESINEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-VTAKYQGL--KSGTF FWPGSDVEINGIFPDIYK-MYNGS----VPFEERILAVLQWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY IYLNKYLGDVKN----IKVIYGPA---ARLRP-----SDVPDKYYSFNYEGIARNLSCQE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNVFSNMQALFVGYGPGFKHGIEA-DTFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYMPKHPKEVHPLVQCPFT---RNPRDNLGCSCNPLILPIEDF------ --QTQFNL--TAAEEKIIKHETLPYGRPRVLQKKNTICLLSQ---HQFMSGYSQDILMPL WTSYTVDRNDSF--STEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNS SGIYSEALLTTNI---VPMYQSFQV-IWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDG RYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTS--QTPLHC--EN-LDTLAFILPH RTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKE---PVSDILKLKTH LPTFSQED-- >NP_001193141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Bos taurus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DSCAGGGSR---- ----GGEGGRG-----PRE--GLAGNG----------------------RDPGPGRAAEA SGEPQAAASLLAPMDLGEEPLERAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDAACVDLGNCCLDYQETCIEPERIWTCTKFRCG ---EKRLSRSLCSCSDDCKDKGDCCINHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNNIYDPQMNANFALKN-KEK-FNPEWY--KGEPIW-LTAKYQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNVS----VPFEERILAILKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDTKD----YKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFKPYLKHFLPKRLHFAKNDRIERLTFYLDPQWQLALNPSE-RK-YCGG-------- ---GFHGSDNTFLNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRPLVQCPFT---RAPRESLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKTIKRGALPYGRPRVLQ-NSTVCLLYQ---HQFVSGYSRDILMPL WTSYTIGRNDSF--STEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGLLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWHYLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSLETLKQNSKIIRNLEVLIPTHFFLVLTSCKNTS--QTPLQC--EN-LDAMAFILPH KTDNSESCAHGKHESLWVEELLKLHTARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >NP_001076211.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryctolagus cuniculus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSQG--- ----GGKGGRG-----PRE--GLAGNG----------------------RDPSHGQASEA PGDPQAAASLLAPMDLGEEPLEKAAGARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCNKFRCG ---EKRLSRSLCACSDDCKERGDCCINYSAVCQGE----KSW-VEETCENINEPQCPEGF EMPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYAKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-LTAKYQGL--RSGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAILKWLRLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDNMVGMLMDGLKELNLHQCLNLILISDHGMEQGSCKKY IYLNKYLGDTKN----IKVIYGPA---ARLRP-----SDVPEKYYSFNYENIARNLSCRE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALSPSE-RK-YCGS-------- ---GFHGSDNVFSNMQALFVGYGPGFQHGIEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPIYTPKHPKEVQPSVQCPLA---GSPRDSLGCSCNPSILPIVDF------ --QTQFNL--TTAEEKNINRASLPYGRPRLLQKKSSVCLLYQ---HQFVSGYSHDVLMPL WTSYTVNRNDSF--STEDFSNCLYQDLRISFSPIHNCSFYKNNAKLSYGFLSPPQLSKDS SQIYSEALLTSNI---VPMYQSFQV-IWRYFHDTLLQRYAEERNSINVVSGPVFDSDYDG RYDSSEALKRNRRVIRNQEILIPTHFFIVITSCKNTS--QTPLQC--DN-LDPLAFILPH RSDNSESCVHEKRESSWIEELLMMHRARIMDVEHITGLSFYQERKE---PVSDILKLKTH LPTVSQED-- >XP_020943592.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Sus scrofa] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRG-----SRE--GPAGNG----------------------RDSGRGHGAEA PGEPQAAASLLAPMDLGEEQLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIAPERIWTCSKFRCG ---EKRLSRSLCSCSDDCRDKGDCCINYSSVCRGE----KSW-VEETCESISEPQCPTGF EKPPVLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNANFALKT-KEK-FNPEWY--KGEPIW-LTAKYQGM--KSGTF FWPGSDVKINGILPDLYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDDMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKN----VKVVYGPA---ARLRP-----SDVPDKYYSFNYEGIAKNLSCQE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGG-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSIEV-DPFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYTPKHPKEVRSLVQCPFT---RAPQENLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKVIKRGTLPYGRPRVLQKNSTVCLLYQ---HQFVSGYSHDLLMPL WTSYTVDRNDSF--SAEDFSNCLYQDLRIPLSPIHKCSFYKNNAKLSYGFLSPPQLNKGS SQVYSEALLTTNM---VPMYQSFQV-IWHYLHGTLLQRYAEERNGINVVSGPVFDSDYDG RYDSLETLKQNSRTIRNQEILIPTHFFIVLTSCKNTS--QIPSQC--EN-LDTLAFILPH RTDNSESCAHGKHESSWVEELLRLHRARITDVEHITGLSFYQERKE---PISDILKLKTQ LPPFNQED-- >XP_024104684.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pongo abelii] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRA-----PRE--GPAGNG----------------------RDRGHSHAAEA PGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCG ---EKRLTRSLCACSDDCKDQGDCCINYSSVCQGE----KSW-VEEPCESVNEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-VTAKYQGL--KSGTF FWPGSDVEINGIFPDIYK-MYNGS----VPFEERILAVLQWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDSMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY IYLNKYLGDVKN----IKVIYGPA---ARLRP-----SDVPDKYYSFNYEGIARNLSCRE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPAE-RK-YCGS-------- ---GFHGSDNIFSNMQALFVGYGPGFRHGIEV-DTFENIEVYNLMCDLLNLTPA-PNNGT RGSLNHLLKNPVYTPKHPKEVHPLVQCPFT---RNPRDNLGCSCNPSILPIEDF------ --QTQFNL--TVAEEKIIKHETLPYGRPRVLQKKNTICLLSQ---HQFMSGYSRDILMPL WTSYTVDRNDSF--STEDFSNCLYQDFRISLSPVHKCSFYKNNTKVSYGFLSPPQLNKNS SRIYSEALLTTNV---VPMYQSFQV-IWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDG RYDSLEILRQKRRVIRNQEILIPTHFFIVLTSCKDTS--QTPLHC--EN-LDTLAFILPH RTDNSESCLHGKHESSWVEELLMLHRARITDVEHITGLSFYQQRKE---PVSDILKLKTH LPTFSQED-- >XP_003638833.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Canis lupus familiaris] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCRDKGDCCVNYSSVCLGE----KSW-VEETCESIDEPQCPAGF EMPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKIYDPKMNAFFALKS-KEK-FNPEWY--KGEPIW-LTTKYQGL--KSGTF FWPGSDVEIKGILPDIYK-MYNGS----IPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKGLNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDVKD----IKIVYGPA---ARLRP-----SDVPNKYFSFNYEDLAKNLSCRE PNQHFKPYLKHFLPKRMHFAKNDRIEPLTFYLDPQWQLALNPSE-RK-HCGS-------- ---GFHGSDNLFSNMQALFIGYGPGFKHNIEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYTPKNPKEVHPMVQCPFT---RAPRHNLDCSCDPSVLPVTDF------ --ETQLNL--TVAEEKVIKRGTLPYGRPRVIQKNTTVCLLYQ---HQFVSGYSHDILMPL WTSYTVDRNDSF--STEDFSNCLYQDLRIPLSPIHKCSFYKNNAELSYGFLYPPQLNKGS NQLYSEALLSTNI---VPMYQSFQV-IWHYFHGTLLQRYVEERNGVNVVSGPVFDSDYDG RYDSSETLRQNSRLIHNQEILIPTHFFIVLTNCKDTF--QTPSQC--DD-LDSLAFILPH RADNSESCVHGKHESLWVEELLRLHRARITDVEHLTGLSFYQERRE---SISDILKLKTQ LPAFDQED-- >XP_003827708.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan paniscus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRA-----PRE--GPAGNG----------------------RDRGRSHAAEA PGDPQAAASLLAPMDVGEEPLEKAVRARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCG ---EKRLTRSLCACSDDCKDQGDCCINYSSVCQGE----KSW-VEEPCESINEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-VTAKYQGL--KSGTF FWPGSDVEINGIFPDIYK-MYNGS----VPFEERILAVLQWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY IYLNKYLGDVKN----IKVIYGPA---ARLRP-----SDVPDKYYSFNYEGIARNLSCQE PNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNVFSNMQALFVGYGPGFKHGIEA-DTFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYMPKHPKEVHPLVQCPFT---RNPRDNLGCSCNPSILPIEDF------ --QTQFNL--TVAEEKIIKHETLPYGRPRVLQKKNTICLLSQ---HQFMSGYSQDILMPL WTSYTVDRNDSF--STEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNS SGIYSEALLTTNI---VPMYQSFQV-IWRYFHDTLLRKYVEERNGVNVVSGPVFDFDYDG RYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTS--QTPLHC--EN-LDTLAFILPH RTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKE---PVSDILKLKTH LPTFSQED-- >XP_023110144.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Felis catus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------GGCSGGGSS---- ----GGEGGRG-----SRE--GPAGNG----------------------HDPSHGRAAQA PGEGQAAASLLAPMDLGEEPLEKAAHARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPEHIWTCSKFRCG ---EKRLPRSLCSCSDDCRDKGDCCVNYSSVCRGE----KSW-VEETCENINEPKCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISRLKNCGTYTRNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKIYDPKMNAYFALKS-KEK-FNPEWY--KGEPIW-ITAKYQGL--KSGTF FWPGSDVEISGIFPDIYK-IYNSS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHQCLNLILVSDHGMEQGSCKKY VYLNKYLGDVKN----IKIVYGPA---ARLRP-----SDVPDKYFSFNYEDLARNLSCRE PNQHFKPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPAE-SK-HCGI-------- ---GFHGSDNIFSNMQALFIGYGPGFKHSIEV-DSFESIEVYNLMCDLLNLSPA-PNNGT HGSLNHLLKHPVYTPTHPKEAHPLAQCPFT---RTPRHNLDCSCDPSVLPVVDF------ --EIQLNL--TVAEEKVIKRGTVPYGRPRVLQRDSTVCLLYQ---HRFVSAYSHDILMPL WTSYTVDRNDSF--STEDFSNCLHQDLRISLNPVHKCSFYKNNAELSYGFLYPPQLNKGS SQLYSEALLNTNI---VPMYQSFQV-IWHYFHGTLLHRYAEERNGVNVVSGPVFDSDYDG CYDSSETLKQNSRRIRNREILIPTHFFIVLTSCKNTF--QTPSQC--GD-LDTLAFILPH RTDNSESCMHGKQDSSWVEELLKLHRARIADVEHITGLSFYQERKE---PISDILKLKTQ LPTFNEED-- >XP_004011375.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Ovis aries] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----SGEGGRS-----PRE--GLAGNG----------------------RDPGPGRAAEA SGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCINHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAYFALKS-KEK-FNPEWY--KGEPIW-LTAKNQGL--KTGTF FWPGSDVKIKGIFPDIYK-IYNVS----IPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDTKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFLNMQALFIGYGPGFKHSTEV-DSFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLNNPVYTPKHPKEVRSLVQCPFT---RAPRESLDCSCDPSILPVVDF------ --QTQLNL--TMAEEKTIRRGTLPYGRPRVLQ-NSTVCLLYQ---HQFVSGFSHDILMPL WTSYTIDRNDSF--FTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWQYLHGTLLQRYAEERNGLNVVSGPVFDSDYDG RYDSLETLKQNSRIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EH-LDTMAFILPH RTDNSESCAHGKRESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >XP_018885608.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Gorilla gorilla gorilla] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----GGEGGRA-----PRE--GPAGNG----------------------RDRGRSHAAEA PGDPQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEV-KSCKGRCFERTF---GNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCG ---EKRLTRSLCACSDDCKDQGDCCINYSSVCQGE----KSW-VEEPCESINEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPKMNASFSLKS-KEK-FNPEWY--KGEPIW-VTAKYQGL--KSGTF FWPGSDVEINGIFPDIYK-MYNGS----VPFEERILAVLQWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY IYLNKYLGDVKN----IKVIYGPA---ARLRP-----SDVPDKYYSFNYEGIARNLSCQE PNQHFKPYLKYFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNIFSNMQALFVGYGPGFKHGIEA-DTFENIEVYNLMCDLLNLTPA-PNNGT HGSLNHLLKNPVYTPKHPKEVHPLVQCPFT---RNPRDNLGCSCNPSILPIEDF------ --QIQFNL--TVAEEKIIKHETLPYGRPRVLQKKNTICLLSQ---HQFMSGYSQDILMPL WTSYTVDRNDSF--STEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNS SGIYSEALLTTNI---VPMYQSFQV-IWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDG RYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTS--QTPLHC--EN-LDTLAFILPH RTDNSESCVHGKHASSWVEELLMLHRARITDVEHITGLSFYQQRKE---PVSDILKLKTH LPTFSQED-- >XP_023808792.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryzias latipes] -M-----------------EE--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T KAEESLPDQEATVFGTSEPEGQKKTSERRKTRIKHSKIIVGVLLLILLIAILAALISMKT KTHRG------------------------------------------------------- ---------------------------------GG----DLW-LEQESHEVQQPTCPPGF SRPPLILVSLDGFRAQYLTDHQSHLRVIGALRNRGTTAPYIRPVYPTKTFPNHYTIVTGL YPESHGIVDNKMYDVTRNAFFSLKNEDEK-CNPKWY--QGEPIW-ITAIRQKL--KAATY FWPGSDVAINGTFPNIFK-EYDSG----ITFKTRVSTLLNWLSLPEEKRPDFYTLYLDEP DSSGHRYGPRSLE-VIDALKNVDDMVGELMDGLTERNLHHCVNIIIISDHGMEEASCEKA AFVSNYLPHTSD----FEVIQGPA---ARIRP-----KRLPEDYFSFDYEGLVRNLSCSA HDLTMTPYLKEHLPKRMHFANNIRIERGHLYMKPGWQAALNQNE-VK-RCSG-------- ---GFHGSDNIFTNMQGIFIGYGPGFLQNTIV-PPFENIEVYNLMCDLLNIRPA-PNNGT HGSLNHLLKNPVHHPVHPAQLSHETPCEAA--EPAPTYSLHCNCSSQINSSETE------ --MNRILLA-SSTKKESQRRVHHPYGTPGVVQSGANFCLLYH---LDYINGYSKDRLMPL WVSYSIQPLLRPPKPRSETDVCVRADVRVPLASSQQCLQYKDDRSLTYGLLHPHYLSFSG PE--TDSLIGTNM---VPMFPAFKK-VWNYIHQSLLPKYSQQLNGINILSGPIFDTDYDG NVDPVREV-------SGNEASIPTHFFLILNSCQNLT--LLPTNC--VGPLKVQSFILPH RPDYSEVCKE-SDLE-FVESWMSFHTARVRDIELLTGLSFYHSMI----SVEETLQLKTF LDTQRAIENS >XP_013224783.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Columba livia] -M-----------------SPRS------------------------------------- -------------------A-------------------------------------LKP PAE----------------------------LLLRL-----------CGYRAGPMPRVRV SVGVRGEAWQA-----RRE--APSACG---------------------------GARQPA GPAAAAAVPMLPAMEVAEEP-EKAPRSK-SKDPNTYKVLSLVLCVCMLTTILGCIFGLKP SCSKDV-KTCKGRCFERTF---GSCRCDKDCVKLGNCCLDYQETCIQPAHIWSCNKFRCG ---EKRRPEYHCSCSDDCVENQDCCVNYNTVCKGE----ASW-VEEECEDITEPQCPKGF TKSPVLLFSLDGFRAEYLQTWGGLLPVISKLRKCGTYTSSMRPVYPSKTFPNHYSIVTGL YPESHGIIDNKMYDPKRNASFTLRS-EEK-FNPQWY--QGQPIW-LTAMYQGL--KAGTF FWPGSDVAVNGSFPNLYE-NYSSS----IPFEERVMTVLRWLQLPEDKRPHFYTLYLEEP DSSGHRFGPVSSG-VIVALQRVDNIVGMLMDGLKQMNLHKCLNIIFISDHGMEAGSCRKT AYLNSYLDDVQG----FILVPGPA---ARLRP-----NNVPDEYFSFNYEGVVRNLTCIE PNQPFKAYMKHLLPKRFHYSYNDRIEPLHFYLESQWQLARKPLE-IK-TCIG-------- ---GFHGSDNRFPSMQAIFIGFGPGFKFRTRV-DPFENIEVYNLMCDLLNLKPA-PNNGT HGRLNHLLRNPVYTPHHPKEVSHPSECSVVG-QRAFSVSPGCSCRTGGLPIRDF------ --HQRLNL--TETEVKKIEQLTLPYGRPRVLQKRHNYCLLYH---DRYVSGYSKDYRMSL WSAYTVNKNDKWVSATEDTSSCLHKDIRIPFNHNQTCLFYNNHPHLTYGFLSPPNFMTDG RKPHYDALLTSNI---VPMYPAFKV-LWNYFHQYLLPEYAAARNGVNVVSGPVFDYDSDG LYDTPEKVK---RHPSNSEVAVPTHFFIVLTSCKNTS--ETPLEC--EGSLDALSFVVPH REDNSESCADGKSESMWVEERMKFHTARIRDIELLTGLSFYQDRKQ---PVSEILQLKTY LPTFETV--- >XP_017909005.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Capra hircus] -M-----------------ER--------------------------------------- ------------------------------------------------------------ -----------------------------------------------DGCAGGGSR---- ----SGEGGRS-----PRE--GLAGNG----------------------RDPGAGRAAEA SGEPQAAASLLAPMDLGEEPLEKAARARRAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCINHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAYFALKS-KEK-FNPEWY--KGEPIW-LTAKNQGL--KTGTF FWPGSDVKIKGIFPDIYK-IYNVS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDTKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEGIAKNLSCQE PNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFLNMQALFIGYGPGFKHSTEV-DSFENIEIYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVSSLGALVKG---HWTRELTSLGC---------------- ------------------------FG---VITKDGNRKERYN---NQFLTRL-------- -----------------DFQKNEYLQFPGSLDFIWGCI---------------------- ----------------------------------ILKIYFSEI----VIKG----NSYFF LKVSITIFYRNSRIIRNQEVLIPTHFFIVLTSCKNTS--QTPLQC--EH-LDTMAFILPH RTDNSESCAHRKRESLWVEELLELHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >XP_025068225.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator sinensis] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------MAVATFT-ALSQ----VRSPS-----AKVLCVCVLTVILGCIFGLKP SCTRDV-KTCKGRCFERTF---GSCRCDADCAKLGNCCLDFQETCIKPAQIWTCNKFRCG ---EKRRPEYHCSCSDDCVENDDCCFNYYAVCQGE----KSW-VEEKCENINESQCPAGF TKPPLLLFSLDGFRVEYLRTWGGLLPAISKLQKCGTYTTSLRPVYPTKTFPNHYSIVTGL YPESHGIVDNKMYDPKRNVSFTLKS-AEK-FNPQWY--QGEPIW-LTAMYQGL--KAGTY FWPGSDAKINGTFPNLYK-IYNSS----IPFEERVTTILQWLKLPEEERPHFYTLYLEEP DTSGHKFGPVSSE-VILALQRVDRIIEMLMDGLKQMNLHKCLNIILVSDHGMEVASCRKT AYLSTYLDNVNN----FMIVAGPA---ARLRP-----INVPDEYLSFDYEGIVRNLTCID SNQPFKAYMKWQLPKRFHFANNDRIEPVHFYLDSQWQLARKPFE-IK-SCKG-------- ---GFHGSDNLFMNMQAIFIGFGPGFKFSTKV-DPFGNIEIYNLMCDLLDLIPA-SNNGT HGSLNHLLKNPVYIPSHPEEASHPSSCSVMK-QKPFPVDRGCICSSSGLPIRDF------ --HQRLNL--TASQEKNIEEYTLPYGKPRVLQKKSVSCLLYH---HQYVSGYSKDLSMPL WSAYTISKSDTWIGSMENISSCLHTDIRTPSSHNQRCLFYKNHPQLNYGFLSPPNLIKDT KNSHYEALLSSNI---VPMYPGFQV-LWNYFYEVLLPKYVVARNGVNVISGPVFDYDYNG IYDVPEKVK---RQPGNSEVLIPTHYYIVLTSCKNIS--QTPLEC--EGALDALSFIIPH REDNSESCASGKSASLWAEERMKFHTARIRDVELLTGLSFHQDRKQ---PVSDILQLKIY LPTFDKV--- >XP_006264801.3 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator mississippiensis] -M-----------------AMR-------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------GDGGGK AAGERAAQPMLPAMEVAEEP-DKAR----RRDPNPYKVLSLVLCVCVLTVILGCIFGLKP SCTRDV-KTCKGRCFERTF---GSCRCDADCAKLGNCCLDFQETCIEPAHIWTCNKFRCG ---EKRRPEYHCSCSDDCVENDDCCFNYYAVCQGE----KSW-VEEKCENINESQCPAGF TKPPLLLFSLDGFRAEYLHTWGGLLPAISKLQKCGTYTPSLRPVYPTKTFPNHYSIVTGL YPESHGIVDNKMYDPKRNASFTLKS-AEK-FNPQWY--QGEPIW-LTAMYQGL--KAGTY FWPGSDAKINGTFPNLYK-IYNGS----IPFEERVTTILKWLKLPEEERPHFYTLYLEEP DTSGHKFGPVSSE-VILALQRVDRIIEMLMDGLKQMNLHKCLNIILVSDHGMEVASCRKT AYLSTYLDNVND----FMIVAGPA---ARLRP-----INVPDEYLSFDYEGIVRNLTCID SNQPFKAYMKWQLPKRFHFANNDRIEPVNFYLDSQWQLARKPFE-IK-YCKG-------- ---GFHGSDNLFMNMQAIFIGFGPGFKFSTKV-DPFGNIEIYNLMCDLLDLIPA-SNNGT HGSLNHLLKNPVYIASHPEEAIHPSSCSVMK-QKPFPVDRGCICSSSGLPVRDF------ --HQRLNL--TASQEKNIEEYTLPYGKPRVLQKKSVSCLLYH---HQYVSGYSKDLSMPL WSAYTISKSDTWIGSMENISSCLHTDIRTPSSHNQRCLFYKNHPQLNYGFLSPPNLIKDT KNSHYEALLSSNI---VPMYPGFQV-LWNYFYEVLLPIYAVARNGVNVISGPVFDYDYNG IYDVPEKVK---RQPGNSEVLIPTHYYIVLTSCKNIS--QTPLEC--EGALDALSFIIPH REDNSESCASGKSASLWAEERMKFHTARIRDVELLTGLSFHQDRKQ---PVSDILQLKIY LPTFDKV--- >XP_015802949.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Nothobranchius furzeri] -M-----------------DG--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------T KGEERSAEQAASLFGTSELENQRSDSERRKKR--ICKIISGILLLFLLIALLAVVISVKL GDKEKE------------------------------------------------------ -------------------------------------------TDSAFEEVHQRQCPPGF PRSPLILVSLDGFRAKYLNDHKSHLPVLNKLRSAGTTAPYIRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDVTQNAFFSLKT-NEK-FNPRWY--HGEPVW-LTAMRQKL--RTATF FWPGSDVPINGTFPDFYK-QYDSQ----IPFEQRLATLFGWLSLPKEQRADFYTLYVDEP DTAGHKYGPESQQ-VISALEKVDKLLGMLMNGLKERRLHRCANVIIMSDHGMEEASCDRA TFVTNYQQHTSD----FIIIQGPA---ARIRP-----KRLPDDYFSFDYEGLVKNLSCRT PEQPMRPYLKENLPKRMHFANNQRIERGHLYMKSGWQAALNQQE-VK-YCTG-------- ---GFHGSDNVFDNMQAIFIGYGPAFKTNTVV-APFENIEIYNLMCDLLEISPA-SNNGT HGSLNHLLKDPYYKPVHRAPLSLDTPCETSDPNPAPTSLLQCRCASQTVEMEKQ------ --MNTVLLAINDETKASLRRLHHPFGTPQIIQPDASFCLLYQ---SDYLTGYSRDIIMPL WVSYVIQPLVHVRAPSPE--ECVRADVRVPPSAGQLCSRFKNHPRLTFGLLHPPYLNSSA PE--TDSLINSNM---VPMFPAFKN-VWTYFHNSLLVKYSQILNGINIISGPIFDTNFDG HADKFNKI-------LGNEADVPTHFFLILTSCRNST--FSPVEC--KGPLQVSAYILPH RPDYSEVCTEGSDYS-FVEKWMSFHTARVRDIELLTGLSFYHDRL----SVEETLQLKTF LHT------- >XP_020738141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Odocoileus virginianus texanus] -MSSSTLTDAKDPAKVEGGERMIVIYSLILVLGTVSLAQSRRPNIRTRDTLSVLITRNWE QEKKKGRFPPPRCALSPLCLSIPKRRGPSRLHSPAFEKPHRRAASSPSTRSILGPHDLMP SADHTLQFQTSPRREATQVSGRCPRREVGKAWRGRLKTRPRGGPKITDTLSARNQT---- ----GSQIIRGVELLSPHSQRRAAGAQ----------------------PRVWRRGAAEA SGEPQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKP SCAKEI-KSCKGRCFERTF---GNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCG ---EKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGE----KSW-AEEECDSIDEPQCPAGF ETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNLRPVYPTKTFPNHYSIVTGL YPESHGIIDNKMYDPQMNAHFALKS-KEK-FNPEWY--KGEPIW-LTAKHQGL--KTGTF FWPGSDVKINGIFPDIYK-IYNGS----VPFEERILAVLKWLQLPKDERPHFYTLYLEEP DSSGHSYGPVSSE-VIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKY VYLNKYLGDIKD----VKVVYGPA---ARLRP-----SDVPDKYYSFDYEDIAKNLSCQE PNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSE-RK-YCGS-------- ---GFHGSDNAFSNMQALFIGYGPGFKHSTEV-DSFENVEVYNLMCDLLNLTPA-PNNGT HGSLNHLLSNPVYTPKHPKEVRSLVQCPFP---RAPRESLDCSCDPSILPIVDF------ --QTQLNL--TMAEEKAIKRGALPYGRPRVLQ-NSTVCLLYQ---HQFVSGYSHDILMPL WTSYTIDRNDSF--FTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGS SQVYSEALLTTNI---VPMYQSFQV-IWHYLHGTLLQKYAEERNGLNVVSGPVFDSDYDG RYDSLETLKQNSKIIRKQEVLIPTHFFIVLTSCKNTS--QTPLQC--EN-LDPLAFILPH RTDNSESCAHGQHESLWVEELLKLHRARITDVEHITGLSFYQERKE---PISDILKLKTH LPTFNQED-- >XP_030261662.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Sparus aurata] -M-----------------DS--------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------A KGEQRSAEQAASLFGASEMESQGRQADRGKKR-NNCKIITGVLLLCLLVLILTVALSLRK SKDES------------------------------------------------------- ---------------------------------GG----QIW-LNEADVEIQQPKCPPSF SRPPLILVSLDGFRAEYLKDHSSHLPVINKLRNTGTTTPYMRPVYPTKTFPNHYSIVTGL YPESHGIVDNKMYDVTQDAFFSLKT-DEK-LNPKWY--QGEPVW-ITAMRQKL--KTGTF FWPGSDVAINGTHPDYYM-VYDKS----ITFEKRVSKLFEWLKLPQGQRPDFYTLYLDEP DSSGHRYGPASTQ-VVEALENVDRILGTLMDGLTQRNLQHCVNLIIVSDHGMEEASCEKA LYVSSYIDNTAD----FSVIQGPA---ARIRP-----SRLPENFFSFDYEGLVKNLSCRT SDQPMRPYLKENLPKRMHFANNKRIERGHLYMKSGWQAALNRKE-LK-YCTG-------- ---GYHGSDNLFTNMQAIFIGYGPGFKESTVV-PPFENIEVYNLMCDLLDIRPS-PNNGT HGSLNHLLKRPVYLPVHPAQLSHETPCKAV--GPVPNDDLQCTCSSLNTTMVTF------ --MNRHLMNTNSSVKASLRRLHHPFGTPRVVQPDASFCLLHH---SSYLSGYSKDRLMPL WVSYTIQPLTRVQPLSPESEACVRADIRIPPAASQLCLRYRDDPALSYGLLHPPNLSVNG PE--TDSLLTSNM---APMFPAFKD-VWVHVHNVLLPKYSQQMNGVNIMSGPIFDGDYDG NVDALKAI-------SGNEAPIPSHFFIILTSCGNST--FSPVDC--EGPLQAKSFILPH RPDHTESCADGSDLT-WVEEWLQFHSGRVRDIELLTGLSFYHDRI----SVEETLQLKTH LQSA------ >XP_040206375.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rana temporaria] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------MDCEARNGG TGTEIQAEPMLNSLDMAEEPVKAAQR-K-KKKSGNWKVLSLVICVVILTAILGCIFGLKP SCSREV-NSCKNRCFERKF---GSCRCDTACVELGNCCLDYKDLCIQPAHIWTCDKLRCG ---EKRLPSSLCSCSDDCKDTNDCCVNYDSVCRGN----KSWVEEENCDEMQTPICPAGF SQPPVILFSLDGFRAEYFHTWNGLLPVISKLKKCGTYTRALRPVYPSKTFPNHYSIVTGL YPESHGVVDNKMYDPYRNAFFTLRS-SEK-FHSSWY--QGEPVW-ITAMNQGL--KAATY FWPGSDVKINGTFPNIYK-EYNGS----IPFENRVISVLKWLRLPENVRPHFYTLYLEEP DSSGHKHSPMSSA-VIKALMEVDQIVGMLMDGLKQMQLDKCVNILLLSDHGMEESRCENI AYLGSYLNTSEE----YIVIHGPA---ARLRP-----NRLPDEYFSFDYADIAKNLTCRK KNQHFKPFLKKDLPKRLHFANNDRIESLHFYSDPKWQVAKSQSEVSK-FCNG-------- ---GFHGSDNLFKNMQALFIAYGPKFKYNTEV-QPFENIEIYNLMCDLLGIEPA-ANNGS HGSLNHLLKKPVYEPSLPKELSEPFQCSVN--HSALGNAFGCSCNLPSLTEAAF------ --KAHLIL--TPEQESDTKRLNLPFGRPVVLQ-NSNYCILYQ---DKYVSGYSYNIKMPL WSSYTIGKNEFVSASLDKNSLCLFMDARVPPGQSQRCQYYHHHPSLKFGFFFPASLRKTS ESTSYSGLTTSNI---GPMYPAFKV-IWDYFQNVILLKYASEKNGVNVISGPIFDYDFDG QSDGFEQIQ---QMSKDTDVYIPTHYYIILTSCKNSS--ESLLLC--TGPLDVISYVVPH RTENSESCADDKDESLWVEQLLRFHAARVRDVELLAALSFFHNTKY---SVSELLQFKTF IPDYL-----
BMGE Cleaned alignment of selected proteins >NP_006199.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Homo sapiens] DGCAGGGEGGRAGPAGNGSHAAEAPGDQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDKGDCCINYSSVCQGEVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVVQCPFNLGCSCNPSILPIEDFTQFNLTVAEEKIIKHETLPYGRPRVLQKICLLSQQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRCDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED >CAE1329719.1 ENPP1_3 [Sepia pharaonis] ISFRVASPSSAASTAEITNGITGACVWELGN-LVREYTVKYTTLNVISGPIFKDGLDNAKRLHSVNCSVPIPTHFYVILSKLSSADMSI-----------------PAEVLPIILPHVEKDQNCLKPKDYFFDHTARIRDIELLTGLTFMTDIPWEKSIKIRTYLPLEMWEKLQHCVNLDK---ACKNASRPVLLISLDGFRADYTNY--EVTPVINRLRECGIQTSFMRSSFPSKTFPNHYTIATGLYPESHGIVGNYMYDMEKNDVFKMST-DPYWWGGETIWKTLSKAGKESGSYFFVGS--SISGVNATYFYPYSGKTSYEDRIDQAVAWIR----QGLPFVSIYFEEPDSTGHREGPSSKQILNTLRLVDSYIGQLMNKLYEENMHNCVNIIIVADHGMTDVNCERSVVLWDIIDKETFVYSDGRVNKYWQKRFSNGSYAITVPELTSKLECSS--RHMKVFQKEFLPKRLHYTKHKRIGDIQLLINDTWYLQRKNL-GSHGYDNRFKSMNALFLAYGPDFKQQLHTEPFQNIEIYNLFTDLLNIPGAPNNGTEGRLHRLLRRP------PPETSV---SFNMNFDDLALFLKKHKEVSLTSMVNSNKKFQEISFGLP-LLKNIQMLKHAYLTAYDTNRKRLLFIAATRKSSQPFFSDAGNGCI-VDPRVHFDQMK---YDQTENNYTWLNLTPADFADDE--ITSFLSTNFIRVAKAFKELWIEALN-VVQKWRTSFSMFTWFVGPIYDYNLDGLADDDDTIK---RF---TNESLPTNVFFVLVGCQNTGEIEA----TTAYILPSNQQHFPKCRK-------MSQMLRDHQARVRDVELLTNLEFYPKEPFVIHRTSMIDVKLPLKD--- >XP_031562620.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like isoform X3 [Actinia tenebrosa] ----------------------------------------------------------------AIKSIIILTLLILLLCNSLGAKIN----------------------------------------------------------------------------------------------------SKSTVLLISFDGFRWDYMDK--TETPNFDSIVKTGVKAKYVKNAFVTKTFPNHFTIVTGLYEESHGIVANTMYDPEFKSWFYLNN-EPRWWGGEPVWITNQNSGGTSGTVFWPGSNVEIRGQYPTYYLKYDHNLXYRDRVDKVVDLLTK--KXPPTLLTLYFEEPDHSGHTYGPESKEVVKAIRTADNVTGYLINHLKAKGLFDKINIIITSDHGMTEISVNNTVYLQDYVPSEWVPITAKEWTLIKPKNG-------YKENIYNRLKNV---SHIKVYKKEAIPMEYHYTNNRRIMPILVVGEEGWSVALSRKVGNHGYSNKYESMHPFFIAHGPAFKSGYLSEPFKNVDIYPLMCHILGIKPAXNNGSLADVQQLLRNEIQ-TVAFFTI-------------------------------------------------------------------------------------------------------------------------------------ITTKKV-----------------------------------------------------------------------------------------AFIV------------------------------------------------------------------- >XP_039259773.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 5-like [Styela clava] -----------------------------------------------------------------NPQIFVKTFLYAILIIFQLAVCE----------------------------------------------------------------------------------------------------HTPKLLLISFDGFRWDYLSK--TDTPNFDRITNNGVRAKWIKDSFTSLTFPNHYTIATGLYEESHGIVANIFYDPVFNETFQIGNLDGKFWGGEPIWVTNQLQGGRTGVYYWPGSEAEIKGVRPNIYEKYIQQALWRNRTDTVIEWLTDPE-NVVDLALLYFKEPDHTGHIYGPESPEVVQMIQQCDNITGYILDQIEEHGLSNLLNIIITSDHGMTGMNRSRFITLDDHIDTHQKHLINYIVTSVWPKSG-----ENITEELYKNLSSIDP-EHVQVWMKKDIPPEYHYANNRRIAPILMSANEGWGIKENWNDGRHGFNNSKMDMHPFFVATGPVFKKGFISEPFENVNIYSLMCHILGINPAPNNGSLDAVKQLLADEYI-PDEEYKY------------------------------------------------------------------------------------------------------------------------------------QFTIAKICFGAIIVIVL------------------------------------------------------------------------------LIYVI---------------------KELKMNSQMRKEVSGFSNSNLKYSER-DENREPLLSTDFP------ >XP_797859.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 [Strongylocentrotus purpuratus] -----------------------------------------------------------------ALSFFLAVAVVITIGDTSAATGN------------------------------------------------------------------------------------------------DNGDDQELLLLVVFDGFRYDYLEK--TATPNFDRLVNMGAKPAGMTPAFATKTFPGHHTIATGLYQENHGIIGNNMYDPEFNSTFGQAN-EPRWWGGEPIWVTNQINGGRTVSVFWPGDRVNISGMTATYHQAYDGSFPNEDRIDLVVGLMSN---GSANLGILYFSEPDNTGHLQGPESNETANSIADCDETLGYLLEKLTEADLLDDVNIIVTSDHGMASVSPDQTVFLDDYVDRSLFYTNNDPVFGLWPYD------ENSTEELYDALKDAH--PNMDVYLKAEIPEEYHYRDNRRTSPILVVMEEGWHVWTNSSIGNHGFLNTLESMRSIFIASGPAFKSNYASDLLDAVDVYNLMCHLLAVDPAPNNGTFSHVEPLLANEGTGTSPETAE-----------------------------------------------------------------------------------------------------------------------------------QMTTEGSIAYSAHLLSLV---------------------------------------------------------FAIFL-----------------AFYF------------------------------------------------------------------- >NP_001129885.1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans] -----------------------------------------------------------------VVIVVIVLLLTQLKAANSNAQNAMSSSKVQLEELTR-------------KLSQPLEQLGPTLERLSNMPGFPMGTTQTPPGVPPISPIVTGPNTTPESPRRSPKAR--KGCQNLGKCE-LSGYTKPPLVILSLDGFAREYVDR--NIVQTLNHIADCGVKADKVYPSYPSKTFPNHYSIVTGLWPESHGITDNSVFDPTISPVLESMK-YEKFFEGEPIWVYKRKTGKKANCLFWVGCAYNNSGYAPDVAPAYNQELPFRNRIDTVVEWLKLPVDERPGLITAYLHEPDNAGH-YQVDEEDVDEKLAEIDENLDYLMSRLSEEKLLECINFAILSDHGMQLI--DKTYYFQDYLDL-KLITAKGVVGRVYINDT-----TISVNDVVDKFRCKI--DTVKTNTRSDVPTRKHYSRDPRVGEVLLEGRAGVTFYKSKADGDHGYDYFNPKMHTIFYARGPSFKQNTTISPYQNIQYMNLWMNLLGIEGAETNGTIGFFDNILTNP---PRRDNPTGECPMVLKCSGNVSAETLNQL-----------SVKLTNCAFSPTNIPLYHCFQNYVIVSRKGNDARRAIIEVLSRDEASN----------------PSNFTFLNAKYQSN--------CPSHIPTGSIRQNSQLSSMVIDVPNNFLLVLDPLQA-KSMEYLNKFGKMYVISGTATDINHDGIAD--------------SNGSVITHIYRIMLICNSTWMNPPLCMDTLSFIFPITEQSTIDCMS-------SDDILLDYTATIFDVERISGFQFGIGAL-SQNQNTIIRRKISTKLW-- >XP_038076960.1 bis(5'-adenosyl)-triphosphatase enpp4-like [Patiria miniata] --------------------------------------------------------------KLGPVNVLLCSFLLTVFSASPYYKQA------------------------------------------------------------------------------------------------PSTSDAPLVLLVSFDGFRWDYLDR--NKTPSFDSFVRDGVKAKYLFDTFASKTFPNHYTIATGLYQESHGIVGNNMYNVSTGAKFTLRHFNSSWWGGEPIWVTNQNQGGHSGLIMYPGMEIQIRGQYPSYRLKYNSTFPYEERINIMTRLFAN---GSINLGLLYFREPDHSGHMLGPNSPDMDAVIQMCDETLGYLMKKLRDAGLGDRVDVIVTSDHGMTPVSKDNFTQLDDFVDPELYYTDNNPVIGIWPHK------ESDVDVIYNKLQGAS--PHVSVYLKDEIPAQYHYRDNPRIAPILLVAKEGWAIHVGNKTGNHGFNNSLMSMHPIFVARGPSFRQGLLVEPFENVNIYPLICKILGLEPAPNNGSLENVQDLLKYSELVTIMTTNEIT--------------------------------------------------------------------------------------------------------------------EPP---------PSTWSTGTIAVAGAILLVA---------------------------------------------------------ACLLLAMCARQ---------------------------------------RSYRQQPREYTPIADTSLEGVD--EIADSGFSSYNYPNTKI-- >XP_006560637.2 bis(5'-adenosyl)-triphosphatase enpp4 isoform X1 [Apis mellifera] -----------------------------------------------------------------NSVIIFALTLVILFNVKYGLLIS----------------------------------------------------------------------------------------------------QHPKLLVVSFDAFRYDYFNR--NLTPFMNKLRHEGTHADYMMNIFVTKTFPNHHTMATGLYAETHGVIDNEYYDVISGNTTKYSY-NLYHYKVLPIWTANEKGGARSGSMMWPGGIYEYQGITPTFTQNFNENIPWEERIDTLISWFIHPI-HPINFGILYIEEPDYHGHGIGIKGLEFDNILRKLDNITKYLHNKIEYHGLND-LNVVHLSDHGMATVKLDRIIDLTKYINSSDKFVGTSPGLHIFPNPGKEETIYQTLKQIASKL------KKFRVYRREEIPKKYHYGNNTRIGPIFVIAEVGYAFQNLLDNGLHGYDNEAIEMHPFFFAKGPAFMSNCKLEPFNNLDLYPLFCKILDLQCPIVNGTLLHLTKCLKKH------QQDIAYRMI----------------------------------------------------------------------------------------------------------------------------IATIISMSMVGVIGAIVMFYMRKRRLGVRSYRRILEDLEA------QYHWDENHDI-----------ENATCKLKNFPDLFIISCYAKN-----------------------------------KHLYAYKGNVKYRKTLFHCR-------------------------- >XP_043313008.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Cervus canadensis] DGCAGGGEGGRGGLAGNGGRAAEASGEQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVGQCPFSLDCSCDPSILPIVDFTQLNLTMAEEKTIKRGALPYGRPRVLR-VCLLYQQFVSGYSQDIVMPLWTSYTIDRNDSFFTEDFSNCFYQDLRIPVSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWNYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDPLAFILPHRTDNRESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >KAB0379402.1 hypothetical protein FD755_007186 [Muntiacus reevesi] DGCAGGGEGGRGGLAGNGGRAAEASGEQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL----------------------------------------------------------------RIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVVQCPFSLDCSCDPSILPIVDFTQLNLTMAEEKTIRRGALPYGRPRVLR-VCLLYQQFVSGYSHDILMPLWTSYTIDRNDSFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWNFLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDPLAFILPHRTDNSESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >KAB0356465.1 hypothetical protein FD754_000621 [Muntiacus muntjak] DGCAGGGEGGRGGLAGNGGSAAEASGEQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSL----------------------------------------------------------------RIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVVQCPFSLDCSCDPSILPIVDFTQLNLTMAEEKTIRRGALPYGRPRVLR-VCLLYQQFVSGYSHDILMPLWTSYTIDRNDSFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWNFLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSSETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDPLAFILPHRTDNSESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_018118655.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Xenopus laevis] MGLSGTESDIRAGTAVNGGGRNGSTGGTLEQSMLNPMTLVEDPGRGSHSAK-KKKSNKWKVLSLVICVCLLTAILGCIFGLKPSCTREVTSCKGRCFERKFGSCRCDSACVELGNCCLDYQDVCIQPAYIWTCEKLRCGEKRLTGSLCSCSDDCSEIQDCCVNYNAVCRGNSEETCEEIQTPQCPSGFSKPPLLLFSLDGFRSEYLHTWGELLPVISKLRKCGTYTTNLRPVYPSKTFPNHYSIVTGLYPESHGLVDNKMYDPKRNAFFTLRNFHPSWYQGEPIWITAMNQGLKAATFFWPGSDVKIKGTYPNIYKMYNSTVKFEERVMSILRWLRLPEQERPHFYTLYLEEPDHSGHGHGPVSSAVIKALMGVDRIVGMLMDGLKQMQLDKCINLILASDHGMEEARCENVAFLSSFLEPSDFIVIPGPAARLRPTKLPDEYFSFDYTGIAKKLTCREPNQHFKAYFKQNLPKRFHFAKNDRIELLNFYTDPKWQVAKTKSDGFHGSDNRFESMQALFIGFGPGFKFKTEVEPFENIEIYNLMCDLLGITSATNNGTHGSLNHLLKNPVYMPSLPHEIFQCSVSLGCSCDSTNLTVFGSQPMTLTPQQESETKKQNLPFGRPVVVQ-YCILYHQYVSGYSYHISMPLWTSYTVGKHAH-SVDSGSSCIFADVRIPSNHSQSCHHYQKHYFLKYGFLYPPGLKESS-SYAGLLTSNIVPMYPAFQVIWNHFHNVLLMKYADKKNGVHVISGPIFDSDFDGQFDTLEQIN---KITEDATVYIPTHYYIVLTSCKNASQTLQQCLDVLSFIVPHRIDNSESCASGKNESLWVEKLLHFHAARVKDVELLTGLSFFHNSKYSVNEILQLKTFLPSSM--- >KAF4024570.1 hypothetical protein G4228_016567 [Cervus hanglu yarkandensis] ------------------------------------MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAYFALKSFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYS------CKSISCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVGQCPFSLDCSCDPS----------------------------------------------------------------DSFFTEDFSNCFYQDLRIPVSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWNYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDPLAFILPHRTDNRESCAHGKHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_010707567.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X6 [Meleagris gallopavo] ------------------GQITRACQPQVISLFAFAFGVNVCMGFTTNRFRRSEEWDEGPI---------------SVLSDSPWISTS-GSCKNRCFELQEPGCRCDNLCKSYNSCCFDFDELCLKTARGWECTKDRCGETRNDDNACHCSEDCLSRGDCCTNYQVVCKGEVDDDCEEIKTPECPAGFVRPPLIIFSVDGFRASYMKKGNKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFSLRGFNHRWWGGQPIWITAAKQGVKAGTFFW------------------SVVIPHERRILTILQWLTLPDNERPYVYAFYSEQPDAAGHRYGPFNSEMVNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDTTCERTEFLSNYLTNVEIILLPGSLGRIRPRS--SNNLKYDPKVIVANLTCRKPDQHFKPYLKHHLPKRLHYAYNRRIEDVHLLVDRKWHVARKAVDGDHGYDNKINSMQTVFIGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRANVYKPTVPDEVLYPVADIGCTCDDKKNKLDELKRFHVKGTEEK-----HLLYGRPAVLY-YNILHHDFESGYSETFLMPLWTSYTISKQAEVVPEHLASCVRPDLRISPGNSQSCSAYRGDKQLSYGFLFPPQLSSSA-KYDAFLITNIIPMYPAFKKVWNYFQRVLVKRYATERNGVNVISGPIFDYDYDGLHDTPEKIK---QFVEGSAIPVPTHYYAIITSCLDFTQPADKCLSVLSYILPHRPDNDESCNSLEDESKWVEDLLKMHTARVRDIEQLTSLDFFRKTSRSYTEILSLKTYLHTFESEI >tr|B0JZL7|B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=enpp1 PE=1 SV=1 -----------------------AKRDHMSEHAANLLGTGQRYTRTHNTAKVQSR--YLKILCAVLLLGLLALILTIIFLLKLRCSDKVDSCKNRCISKSHAGCRCDAACVNEGTCCLDYEEVCLQPTQLWTCSKFRCGEDRLPSSLCSCSADCVKVGDCCANYKRTCEGELQEDCEDIRTPQCPAGFSKSPLLLVSLDGFRAGYMNAYSALLPAIRKLRECGTSTPYMRPAYPTKTFPNHYTIVTGLYPETHGIVDNKMYDVNRNASFSLKVFNPLWYQGEPVWITAMKNHLKTATFFWPGSDVKVHGRYPDYWIKYNRNILFEKRIAQIFQWLHLPEGERPDFYTLYFEEPDASGHKYGPMSTQVIEALINVDRLIGMLMDGLKERNLHKCVNVVLVSDHGMEEASCKKAAYVSNYLDNINITVIQGPAARVRPRHVPEEFFSFDYEGLVKNLSCREPNQPMKPYLKEHLPKRLHFAKNIRIERAHLYMQPQWQAALKPSEGFHGSDNVFKNMQAIFIGYGPGIHYNTTVPPFENIEVYNLLCDLLGISPAANNGTHGSLNHILKKPRYQPVFPAERSTCSAPRGCTCDSLTEAEVNRNQRLINSNSDSNVKPVHLPFGIPRVLQDYCILHHSYISGYSRDILMPLWVSYSLNTTVV-LHPSAEWCVRADVRVQASDRQSCSIYKNNSSMSFGLLHPPNFSPAG--PDSLITSNMVPMYPGFKDIWTHFHNFLLIKFSEEMNGINVVSGPIFDNDFDGNYDFMNKG-------VLNGAPIPTHFFIILTSCKNSSLSVRQCLDAVSFILPHRPDHLETCHNGTDYS-WFQDWVQLHVARIRDIELLTGLSFYHDRI-SVAETLQLKTRLKTF---- >NP_032839.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 2 [Mus musculus] D----GDQAGHGGSAGNG--------EPAAASLLAPMDLGEEPLEKAERARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKTHNDCCINYSSVCQDKVEETCESIDTPECPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPMYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPLWYKGQPIWVTANHQEVKSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDRLVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNVKVVYGPAARLRPTDVPETYYSFNYEALAKNLSCREPNQHFRPYLKPFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPSHPKEESQCPIDLGCTCDPWIVPIKDFKQLNLTT-EDDDIYHMTVPYGRPRILLKVCLLQQQFLTGYSLDLLMPLWASYTFLSNDQFSRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRLNRVSIYSEALLTSNIVPMYQSFQVIWHYLHDTLLQRYAHERNGINVVSGPVFDFDYDGRYDSLEILKQNSRVIRSQEILIPTHFFIVLTSCKQLSETPLECLESSAYILPHRPDNIESCTHGKRESSWVEELLTLHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED >NP_445987.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rattus norvegicus] D----GEQAGQGGPAGNG--------EPAAASLLAPMDLGEEPLEKAERARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFSNCRCDAACVSLGNCCLDFQETCVEPTHIWTCNKFRCGEKRLSRFVCSCADDCKAHNDCCINYSSVCQEKVEEACETIDAPQCPAEFESPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPLWYKGQPIWVTANHQEVRSGTYFWPGSDVEIDGILPDIYKVYNGSVPFEERILAVLEWLQLPSYERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKVDHIVGMLMDGLKDLGLDKCLNLILISDHGMEQGSCKKYVYLNKYLGDVNVKVVYGPAARLRPTEVPETYYSFNYEALAKNLSCRETNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSEGFHGSDNLFSNMQALFIGYGPAFKHGAEVDSFENIEVYNLMCDLLGLIPAPNNESHGSLNHLLKKPIYTPSHPKEESQCPIDLGCTCDPSIVPIMDFKQFNLTTDAVEDVYSMTVPNGRPRNLQKVCLLHQQFLTGYSLDLLMPLWTSYTFLSNDQFSTDDFSNCLYQDLRIPLSPMHKCSYYKSTSKLSYGFLTPPRLNRVSIYSEALLTSNIVPMYQSFQVIWQYLHDTVLRRYAQERNGVNVVSGPVFDFDYDGRYDSSEILKQNTRVIRSQENLIPTHFFIVLTSCKQLSESPLKCLESSAFLLPHRPDNIESCTHGKQESAWVEELLALHRARVTDVELITGLSFYQDRQESVSELLRLKTHLPIFSQED >XP_004940275.3 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Gallus gallus] NGEKA---AGNG---GLGGRGAADGELAAAVPMLPALEVAEEP-EKAPGGK-SKDPNTYKVLSLVLCVCVLTTILGCIFGLKPSCSKDVKTCKGRCFERTFGSCRCDRDCVKLGNCCLDYQETCIQPAHIWTCNKFRCGEKRRPEYHCSCSDDCVENNDCCVNYQAACKGEVEEECEDITEPQCPKGFKKSPVLLFSLDGFRAEYLQTWGGLLPVISKLQKCGTYTSSMRPVYPSKTFPNHYSIVTGLYPESHGIIDNKMYDLKRNAYFTLKSFNPEWYQGQPIWLTAMYQGLKAGTFFWPGSDVAVDGTFPDLYKEYNGSIPFEERVVTVLRWLQLPEDERPHFYTLYLEEPDFSGHKFGPVSSGVILALQRVDTIVGMLMDGLKQMNLHKCLNIIFVSDHGMEAGSCRKTAYLNSYLDNVQFIIVPGPAARLRPNNVPDEYFSFNYEGIVRNLTCVEPNQPFKAYMKQFLPKRFHYANNDRIEPLHFYLNSQWQLARKPLEGFHGSDNRFPSMQAIFIGFGPGFKFQTQVDPFENIEVYNLMCDLLDLKPAPNNGTHGRLNNLLRNPVYTPHHPKETSECSFSPGCSCRTAGLPVRDFQRLNLTETEVKKIETLALPYGRPRVLQKYCLLYHRYVNGYSKDYKMSLWSAYTVNKNDNWTTEDISSCLHKDVRIPSNHNQTCSFYNNHPRLTYGFLSPPNFMTDASHYDSLLTSNIVPMYPAFKVLWSYFHQSLLPEYAADRNGVNVVSGPVFDYDSDGIYDTPEKVK---RHPGNSEVPIPTHFFIVLTTCKNTSETPLKCLDALSFIVPHREDNSESCADGRSESLWVEERMKFHIARVRDIELLTGLSFYQDRKQPISDILQLKTYLPTFETV- >XP_016811798.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan troglodytes] DGCAGGGEGGRAGPAGNGSHAAEAPGDQAAASLLAPMDVGEEPLEKAVRARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYMPKHPKEVVQCPFNLGCSCNPLILPIEDFTQFNLTAAEEKIIKHETLPYGRPRVLQKICLLSQQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED >NP_001193141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Bos taurus] DSCAGGGEGGRGGLAGNGGRAAEASGEQAAASLLAPMDLGEEPLERAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDAACVDLGNCCLDYQETCIEPERIWTCTKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNNIYDPQMNANFALKNFNPEWYKGEPIWLTAKYQGLKTGTFFWPGSDVKINGIFPDIYKIYNVSVPFEERILAILKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDTKYKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFKPYLKHFLPKRLHFAKNDRIERLTFYLDPQWQLALNPSEGFHGSDNTFLNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVVQCPFSLDCSCDPSILPIVDFTQLNLTMAEEKTIKRGALPYGRPRVLQ-VCLLYQQFVSGYSRDILMPLWTSYTIGRNDSFSTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGLLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWHYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRNLEVLIPTHFFLVLTSCKNTSQTPLQCLDAMAFILPHKTDNSESCAHGKHESLWVEELLKLHTARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >NP_001076211.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryctolagus cuniculus] DGCAGGGKGGRGGLAGNGGQASEAPGDQAAASLLAPMDLGEEPLEKAAGARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCNKFRCGEKRLSRSLCACSDDCKERGDCCINYSAVCQGEVEETCENINEPQCPEGFEMPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYAKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWLTAKYQGLRSGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAILKWLRLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDNMVGMLMDGLKELNLHQCLNLILISDHGMEQGSCKKYIYLNKYLGDTKIKVIYGPAARLRPSDVPEKYYSFNYENIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALSPSEGFHGSDNVFSNMQALFVGYGPGFQHGIEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPIYTPKHPKEVVQCPLSLGCSCNPSILPIVDFTQFNLTTAEEKNINRASLPYGRPRLLQKVCLLYQQFVSGYSHDVLMPLWTSYTVNRNDSFSTEDFSNCLYQDLRISFSPIHNCSFYKNNAKLSYGFLSPPQLSKDSIYSEALLTSNIVPMYQSFQVIWRYFHDTLLQRYAEERNSINVVSGPVFDSDYDGRYDSSEALKRNRRVIRNQEILIPTHFFIVITSCKNTSQTPLQCLDPLAFILPHRSDNSESCVHEKRESSWIEELLMMHRARIMDVEHITGLSFYQERKEPVSDILKLKTHLPTVSQED >XP_020943592.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [Sus scrofa] DGCAGGGEGGRGGPAGNGGHGAEAPGEQAAASLLAPMDLGEEQLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIAPERIWTCSKFRCGEKRLSRSLCSCSDDCRDKGDCCINYSSVCRGEVEETCESISEPQCPTGFEKPPVLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNANFALKTFNPEWYKGEPIWLTAKYQGMKSGTFFWPGSDVKINGILPDLYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDDMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYSFNYEGIAKNLSCQEPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSIEVDPFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVVQCPFNLDCSCDPSILPIVDFTQLNLTMAEEKVIKRGTLPYGRPRVLQKVCLLYQQFVSGYSHDLLMPLWTSYTVDRNDSFSAEDFSNCLYQDLRIPLSPIHKCSFYKNNAKLSYGFLSPPQLNKGSVYSEALLTTNMVPMYQSFQVIWHYLHGTLLQRYAEERNGINVVSGPVFDSDYDGRYDSLETLKQNSRTIRNQEILIPTHFFIVLTSCKNTSQIPSQCLDTLAFILPHRTDNSESCAHGKHESSWVEELLRLHRARITDVEHITGLSFYQERKEPISDILKLKTQLPPFNQED >XP_024104684.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pongo abelii] DGCAGGGEGGRAGPAGNGSHAAEAPGDQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEVEEPCESVNEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDSMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCREPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPAEGFHGSDNIFSNMQALFVGYGPGFRHGIEVDTFENIEVYNLMCDLLNLTPAPNNGTRGSLNHLLKNPVYTPKHPKEVVQCPFNLGCSCNPSILPIEDFTQFNLTVAEEKIIKHETLPYGRPRVLQKICLLSQQFMSGYSRDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRISLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSIYSEALLTTNVVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLEILRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCLDTLAFILPHRTDNSESCLHGKHESSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED >XP_003638833.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Canis lupus familiaris] ------------------------------------MDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCRDKGDCCVNYSSVCLGEVEETCESIDEPQCPAGFEMPPTLLFSLDGFRAEYLHTWGGLLPVISKLKNCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKIYDPKMNAFFALKSFNPEWYKGEPIWLTTKYQGLKSGTFFWPGSDVEIKGILPDIYKMYNGSIPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKGLNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDVKIKIVYGPAARLRPSDVPNKYFSFNYEDLAKNLSCREPNQHFKPYLKHFLPKRMHFAKNDRIEPLTFYLDPQWQLALNPSEGFHGSDNLFSNMQALFIGYGPGFKHNIEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKNPKEVVQCPFNLDCSCDPSVLPVTDFTQLNLTVAEEKVIKRGTLPYGRPRVIQKVCLLYQQFVSGYSHDILMPLWTSYTVDRNDSFSTEDFSNCLYQDLRIPLSPIHKCSFYKNNAELSYGFLYPPQLNKGSLYSEALLSTNIVPMYQSFQVIWHYFHGTLLQRYVEERNGVNVVSGPVFDSDYDGRYDSSETLRQNSRLIHNQEILIPTHFFIVLTNCKDTFQTPSQCLDSLAFILPHRADNSESCVHGKHESLWVEELLRLHRARITDVEHLTGLSFYQERRESISDILKLKTQLPAFDQED >XP_003827708.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Pan paniscus] DGCAGGGEGGRAGPAGNGSHAAEAPGDQAAASLLAPMDVGEEPLEKAVRARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPYLKHFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNVFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYMPKHPKEVVQCPFNLGCSCNPSILPIEDFTQFNLTVAEEKIIKHETLPYGRPRVLQKICLLSQQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYVEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCLDTLAFILPHRTDNSESCVHGKHDSSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED >XP_023110144.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Felis catus] GGCSGGGEGGRGGPAGNGGRAAQAPGEQAAASLLAPMDLGEEPLEKAAHARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPEHIWTCSKFRCGEKRLPRSLCSCSDDCRDKGDCCVNYSSVCRGEVEETCENINEPKCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISRLKNCGTYTRNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKIYDPKMNAYFALKSFNPEWYKGEPIWITAKYQGLKSGTFFWPGSDVEISGIFPDIYKIYNSSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHQCLNLILVSDHGMEQGSCKKYVYLNKYLGDVKIKIVYGPAARLRPSDVPDKYFSFNYEDLARNLSCREPNQHFKPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPAEGFHGSDNIFSNMQALFIGYGPGFKHSIEVDSFESIEVYNLMCDLLNLSPAPNNGTHGSLNHLLKHPVYTPTHPKEAAQCPFNLDCSCDPSVLPVVDFIQLNLTVAEEKVIKRGTVPYGRPRVLQRVCLLYQRFVSAYSHDILMPLWTSYTVDRNDSFSTEDFSNCLHQDLRISLNPVHKCSFYKNNAELSYGFLYPPQLNKGSLYSEALLNTNIVPMYQSFQVIWHYFHGTLLHRYAEERNGVNVVSGPVFDSDYDGCYDSSETLKQNSRRIRNREILIPTHFFIVLTSCKNTFQTPSQCLDTLAFILPHRTDNSESCMHGKQDSSWVEELLKLHRARIADVEHITGLSFYQERKEPISDILKLKTQLPTFNEED >XP_004011375.4 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Ovis aries] DGCAGSGEGGRSGLAGNGGRAAEASGEQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAYFALKSFNPEWYKGEPIWLTAKNQGLKTGTFFWPGSDVKIKGIFPDIYKIYNVSIPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDTKVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFLNMQALFIGYGPGFKHSTEVDSFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLNNPVYTPKHPKEVVQCPFSLDCSCDPSILPVVDFTQLNLTMAEEKTIRRGTLPYGRPRVLQ-VCLLYQQFVSGFSHDILMPLWTSYTIDRNDSFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWQYLHGTLLQRYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSRIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDTMAFILPHRTDNSESCAHGKRESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_018885608.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Gorilla gorilla gorilla] DGCAGGGEGGRAGPAGNGSHAAEAPGDQAAASLLAPMDVGEEPLEKAARARTAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEVKSCKGRCFERTFGNCRCDAACVELGNCCLDYQETCIEPEHIWTCNKFRCGEKRLTRSLCACSDDCKDQGDCCINYSSVCQGEVEEPCESINEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKKCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPKMNASFSLKSFNPEWYKGEPIWVTAKYQGLKSGTFFWPGSDVEINGIFPDIYKMYNGSVPFEERILAVLQWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIKALQRVDGMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYIYLNKYLGDVKIKVIYGPAARLRPSDVPDKYYSFNYEGIARNLSCQEPNQHFKPYLKYFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNIFSNMQALFVGYGPGFKHGIEADTFENIEVYNLMCDLLNLTPAPNNGTHGSLNHLLKNPVYTPKHPKEVVQCPFNLGCSCNPSILPIEDFIQFNLTVAEEKIIKHETLPYGRPRVLQKICLLSQQFMSGYSQDILMPLWTSYTVDRNDSFSTEDFSNCLYQDFRIPLSPVHKCSFYKNNTKVSYGFLSPPQLNKNSIYSEALLTTNIVPMYQSFQVIWRYFHDTLLRKYAEERNGVNVVSGPVFDFDYDGRYDSLENLRQKRRVIRNQEILIPTHFFIVLTSCKDTSQTPLHCLDTLAFILPHRTDNSESCVHGKHASSWVEELLMLHRARITDVEHITGLSFYQQRKEPVSDILKLKTHLPTFSQED >XP_023808792.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Oryzias latipes] -----------------------TKAESLPDQEATVFGTSEPEGQKKTSERRKTRIKHSKIIVGVLLLILLIAILAALISMKTKTHRG---------------------------------------------------------------------------------GGLEQESHEVQQPTCPPGFSRPPLILVSLDGFRAQYLTDHQSHLRVIGALRNRGTTAPYIRPVYPTKTFPNHYTIVTGLYPESHGIVDNKMYDVTRNAFFSLKNCNPKWYQGEPIWITAIRQKLKAATYFWPGSDVAINGTFPNIFKEYDSGITFKTRVSTLLNWLSLPEEKRPDFYTLYLDEPDSSGHRYGPRSLEVIDALKNVDDMVGELMDGLTERNLHHCVNIIIISDHGMEEASCEKAAFVSNYLPHTSFEVIQGPAARIRPKRLPEDYFSFDYEGLVRNLSCSAHDLTMTPYLKEHLPKRMHFANNIRIERGHLYMKPGWQAALNQNEGFHGSDNIFTNMQGIFIGYGPGFLQNTIVPPFENIEVYNLMCDLLNIRPAPNNGTHGSLNHLLKNPVHHPVHPAQLTPCEASLHCNCSSQINSSETENRILLSSTKKESQRRVHHPYGTPGVVQSFCLLYHDYINGYSKDRLMPLWVSYSIQPLLRPPRSETDVCVRADVRVPLASSQQCLQYKDDRSLTYGLLHPHYLSFSG--TDSLIGTNMVPMFPAFKKVWNYIHQSLLPKYSQQLNGINILSGPIFDTDYDGNVDPVREV-------SGNEASIPTHFFLILNSCQNLTLLPTNCLKVQSFILPHRPDYSEVCKE-SDLE-FVESWMSFHTARVRDIELLTGLSFYHSMI-SVEETLQLKTFLDTQRAIE >XP_013224783.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Columba livia] CGYRARGEAWQAAPSACGGARQPAGPAAAAVPMLPAMEVAEEP-EKAPRSK-SKDPNTYKVLSLVLCVCMLTTILGCIFGLKPSCSKDVKTCKGRCFERTFGSCRCDKDCVKLGNCCLDYQETCIQPAHIWSCNKFRCGEKRRPEYHCSCSDDCVENQDCCVNYNTVCKGEVEEECEDITEPQCPKGFTKSPVLLFSLDGFRAEYLQTWGGLLPVISKLRKCGTYTSSMRPVYPSKTFPNHYSIVTGLYPESHGIIDNKMYDPKRNASFTLRSFNPQWYQGQPIWLTAMYQGLKAGTFFWPGSDVAVNGSFPNLYENYSSSIPFEERVMTVLRWLQLPEDKRPHFYTLYLEEPDSSGHRFGPVSSGVIVALQRVDNIVGMLMDGLKQMNLHKCLNIIFISDHGMEAGSCRKTAYLNSYLDDVQFILVPGPAARLRPNNVPDEYFSFNYEGVVRNLTCIEPNQPFKAYMKHLLPKRFHYSYNDRIEPLHFYLESQWQLARKPLEGFHGSDNRFPSMQAIFIGFGPGFKFRTRVDPFENIEVYNLMCDLLNLKPAPNNGTHGRLNHLLRNPVYTPHHPKEVSECSVSPGCSCRTGGLPIRDFQRLNLTETEVKKIEQLTLPYGRPRVLQKYCLLYHRYVSGYSKDYRMSLWSAYTVNKNDKWATEDTSSCLHKDIRIPFNHNQTCLFYNNHPHLTYGFLSPPNFMTDGPHYDALLTSNIVPMYPAFKVLWNYFHQYLLPEYAAARNGVNVVSGPVFDYDSDGLYDTPEKVK---RHPSNSEVAVPTHFFIVLTSCKNTSETPLECLDALSFVVPHREDNSESCADGKSESMWVEERMKFHTARIRDIELLTGLSFYQDRKQPVSEILQLKTYLPTFETV- >XP_017909005.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Capra hircus] DGCAGSGEGGRSGLAGNGGRAAEASGEQAAASLLAPMDLGEEPLEKAARARRAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCINHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNMRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAYFALKSFNPEWYKGEPIWLTAKNQGLKTGTFFWPGSDVKIKGIFPDIYKIYNVSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDTKVKVVYGPAARLRPSDVPDKYYSFDYEGIAKNLSCQEPNQHFRPYLKHFLPKRLHFAKNDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFLNMQALFIGYGPGFKHSTEVDSFENIEIYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVGALVKLTSLGC-----------------------------FG---VITKRKERYNQFLTRL-----------------------DFQKNEYLQFPGSLDFIWGCI--------------------------------------------------ILKIYFSEI----VIKG----NSYFFLKVSITIFYRNSRIIRNQEVLIPTHFFIVLTSCKNTSQTPLQCLDTMAFILPHRTDNSESCAHRKRESLWVEELLELHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_025068225.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator sinensis] ------------------------------------MAVATFT-ALSQ----VRSPS-----AKVLCVCVLTVILGCIFGLKPSCTRDVKTCKGRCFERTFGSCRCDADCAKLGNCCLDFQETCIKPAQIWTCNKFRCGEKRRPEYHCSCSDDCVENDDCCFNYYAVCQGEVEEKCENINESQCPAGFTKPPLLLFSLDGFRVEYLRTWGGLLPAISKLQKCGTYTTSLRPVYPTKTFPNHYSIVTGLYPESHGIVDNKMYDPKRNVSFTLKSFNPQWYQGEPIWLTAMYQGLKAGTYFWPGSDAKINGTFPNLYKIYNSSIPFEERVTTILQWLKLPEEERPHFYTLYLEEPDTSGHKFGPVSSEVILALQRVDRIIEMLMDGLKQMNLHKCLNIILVSDHGMEVASCRKTAYLSTYLDNVNFMIVAGPAARLRPINVPDEYLSFDYEGIVRNLTCIDSNQPFKAYMKWQLPKRFHFANNDRIEPVHFYLDSQWQLARKPFEGFHGSDNLFMNMQAIFIGFGPGFKFSTKVDPFGNIEIYNLMCDLLDLIPASNNGTHGSLNHLLKNPVYIPSHPEEASSCSVDRGCICSSSGLPIRDFQRLNLTASQEKNIEEYTLPYGKPRVLQKSCLLYHQYVSGYSKDLSMPLWSAYTISKSDTWSMENISSCLHTDIRTPSSHNQRCLFYKNHPQLNYGFLSPPNLIKDTSHYEALLSSNIVPMYPGFQVLWNYFYEVLLPKYVVARNGVNVISGPVFDYDYNGIYDVPEKVK---RQPGNSEVLIPTHYYIVLTSCKNISQTPLECLDALSFIIPHREDNSESCASGKSASLWAEERMKFHTARIRDVELLTGLSFHQDRKQPVSDILQLKIYLPTFDKV- >XP_006264801.3 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Alligator mississippiensis] ------------------GDGGGKAAGRAAQPMLPAMEVAEEP-DKAR----RRDPNPYKVLSLVLCVCVLTVILGCIFGLKPSCTRDVKTCKGRCFERTFGSCRCDADCAKLGNCCLDFQETCIEPAHIWTCNKFRCGEKRRPEYHCSCSDDCVENDDCCFNYYAVCQGEVEEKCENINESQCPAGFTKPPLLLFSLDGFRAEYLHTWGGLLPAISKLQKCGTYTPSLRPVYPTKTFPNHYSIVTGLYPESHGIVDNKMYDPKRNASFTLKSFNPQWYQGEPIWLTAMYQGLKAGTYFWPGSDAKINGTFPNLYKIYNGSIPFEERVTTILKWLKLPEEERPHFYTLYLEEPDTSGHKFGPVSSEVILALQRVDRIIEMLMDGLKQMNLHKCLNIILVSDHGMEVASCRKTAYLSTYLDNVNFMIVAGPAARLRPINVPDEYLSFDYEGIVRNLTCIDSNQPFKAYMKWQLPKRFHFANNDRIEPVNFYLDSQWQLARKPFEGFHGSDNLFMNMQAIFIGFGPGFKFSTKVDPFGNIEIYNLMCDLLDLIPASNNGTHGSLNHLLKNPVYIASHPEEASSCSVDRGCICSSSGLPVRDFQRLNLTASQEKNIEEYTLPYGKPRVLQKSCLLYHQYVSGYSKDLSMPLWSAYTISKSDTWSMENISSCLHTDIRTPSSHNQRCLFYKNHPQLNYGFLSPPNLIKDTSHYEALLSSNIVPMYPGFQVLWNYFYEVLLPIYAVARNGVNVISGPVFDYDYNGIYDVPEKVK---RQPGNSEVLIPTHYYIVLTSCKNISQTPLECLDALSFIIPHREDNSESCASGKSASLWAEERMKFHTARIRDVELLTGLSFHQDRKQPVSDILQLKIYLPTFDKV- >XP_015802949.1 PREDICTED: ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Nothobranchius furzeri] -----------------------TKGERSAEQAASLFGTSELENQRSDSERRKKR--ICKIISGILLLFLLIALLAVVISVKLGDKEKE----------------------------------------------------------------------------------TDSAFEEVHQRQCPPGFPRSPLILVSLDGFRAKYLNDHKSHLPVLNKLRSAGTTAPYIRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDVTQNAFFSLKTFNPRWYHGEPVWLTAMRQKLRTATFFWPGSDVPINGTFPDFYKQYDSQIPFEQRLATLFGWLSLPKEQRADFYTLYVDEPDTAGHKYGPESQQVISALEKVDKLLGMLMNGLKERRLHRCANVIIMSDHGMEEASCDRATFVTNYQQHTSFIIIQGPAARIRPKRLPDDYFSFDYEGLVKNLSCRTPEQPMRPYLKENLPKRMHFANNQRIERGHLYMKSGWQAALNQQEGFHGSDNVFDNMQAIFIGYGPAFKTNTVVAPFENIEIYNLMCDLLEISPASNNGTHGSLNHLLKDPYYKPVHRAPLTPCETLLQCRCASQTVEMEKQNTVLLNDETKASLRRLHHPFGTPQIIQPFCLLYQDYLTGYSRDIIMPLWVSYVIQPLVHVPSPE--ECVRADVRVPPSAGQLCSRFKNHPRLTFGLLHPPYLNSSA--TDSLINSNMVPMFPAFKNVWTYFHNSLLVKYSQILNGINIISGPIFDTNFDGHADKFNKI-------LGNEADVPTHFFLILTSCRNSTFSPVECLQVSAYILPHRPDYSEVCTEGSDYS-FVEKWMSFHTARVRDIELLTGLSFYHDRL-SVEETLQLKTFLHT----- >XP_020738141.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Odocoileus virginianus texanus] DTLSAGSQIIRGRAAGAQRGAAEASGEQAAASLLAPMDLGEEPLEKAARARPAKDPNTYKVLSLVLSVCVLTTILGCIFGLKPSCAKEIKSCKGRCFERTFGNCRCDVACVDLGNCCLDYQETCIEPERIWTCSKFRCGEKRLSRSLCSCSDDCKDKGDCCVNHGSVCRGEAEEECDSIDEPQCPAGFETPPTLLFSLDGFRAEYLHTWGGLLPVISKLKTCGTYTKNLRPVYPTKTFPNHYSIVTGLYPESHGIIDNKMYDPQMNAHFALKSFNPEWYKGEPIWLTAKHQGLKTGTFFWPGSDVKINGIFPDIYKIYNGSVPFEERILAVLKWLQLPKDERPHFYTLYLEEPDSSGHSYGPVSSEVIRALQRVDNMVGMLMDGLKELNLHRCLNLILISDHGMEQGSCKKYVYLNKYLGDIKVKVVYGPAARLRPSDVPDKYYSFDYEDIAKNLSCQEPNQHFKPYLKQFLPKRLHFAKSDRIEPLTFYLDPQWQLALNPSEGFHGSDNAFSNMQALFIGYGPGFKHSTEVDSFENVEVYNLMCDLLNLTPAPNNGTHGSLNHLLSNPVYTPKHPKEVVQCPFSLDCSCDPSILPIVDFTQLNLTMAEEKAIKRGALPYGRPRVLQ-VCLLYQQFVSGYSHDILMPLWTSYTIDRNDSFFTEDFSNCLYQDLRIPLSPVHKCSFYKNNAKLSYGFLSPPQLHKGSVYSEALLTTNIVPMYQSFQVIWHYLHGTLLQKYAEERNGLNVVSGPVFDSDYDGRYDSLETLKQNSKIIRKQEVLIPTHFFIVLTSCKNTSQTPLQCLDPLAFILPHRTDNSESCAHGQHESLWVEELLKLHRARITDVEHITGLSFYQERKEPISDILKLKTHLPTFNQED >XP_030261662.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1-like [Sparus aurata] -----------------------AKGERSAEQAASLFGASEMESQGRQADRGKKR-NNCKIITGVLLLCLLVLILTVALSLRKSKDES---------------------------------------------------------------------------------GGLNEADVEIQQPKCPPSFSRPPLILVSLDGFRAEYLKDHSSHLPVINKLRNTGTTTPYMRPVYPTKTFPNHYSIVTGLYPESHGIVDNKMYDVTQDAFFSLKTLNPKWYQGEPVWITAMRQKLKTGTFFWPGSDVAINGTHPDYYMVYDKSITFEKRVSKLFEWLKLPQGQRPDFYTLYLDEPDSSGHRYGPASTQVVEALENVDRILGTLMDGLTQRNLQHCVNLIIVSDHGMEEASCEKALYVSSYIDNTAFSVIQGPAARIRPSRLPENFFSFDYEGLVKNLSCRTSDQPMRPYLKENLPKRMHFANNKRIERGHLYMKSGWQAALNRKEGYHGSDNLFTNMQAIFIGYGPGFKESTVVPPFENIEVYNLMCDLLDIRPSPNNGTHGSLNHLLKRPVYLPVHPAQLTPCKADLQCTCSSLNTTMVTFNRHLMNSSVKASLRRLHHPFGTPRVVQPFCLLHHSYLSGYSKDRLMPLWVSYTIQPLTRVLSPESEACVRADIRIPPAASQLCLRYRDDPALSYGLLHPPNLSVNG--TDSLLTSNMAPMFPAFKDVWVHVHNVLLPKYSQQMNGVNIMSGPIFDGDYDGNVDALKAI-------SGNEAPIPSHFFIILTSCGNSTFSPVDCLQAKSFILPHRPDHTESCADGSDLT-WVEEWLQFHSGRVRDIELLTGLSFYHDRI-SVEETLQLKTHLQSA---- >XP_040206375.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [Rana temporaria] ------------------EARNGGTGTIQAEPMLNSLDMAEEPVKAAQR-K-KKKSGNWKVLSLVICVVILTAILGCIFGLKPSCSREVNSCKNRCFERKFGSCRCDTACVELGNCCLDYKDLCIQPAHIWTCDKLRCGEKRLPSSLCSCSDDCKDTNDCCVNYDSVCRGNEEENCDEMQTPICPAGFSQPPVILFSLDGFRAEYFHTWNGLLPVISKLKKCGTYTRALRPVYPSKTFPNHYSIVTGLYPESHGVVDNKMYDPYRNAFFTLRSFHSSWYQGEPVWITAMNQGLKAATYFWPGSDVKINGTFPNIYKEYNGSIPFENRVISVLKWLRLPENVRPHFYTLYLEEPDSSGHKHSPMSSAVIKALMEVDQIVGMLMDGLKQMQLDKCVNILLLSDHGMEESRCENIAYLGSYLNTSEYIVIHGPAARLRPNRLPDEYFSFDYADIAKNLTCRKKNQHFKPFLKKDLPKRLHFANNDRIESLHFYSDPKWQVAKSQSEGFHGSDNLFKNMQALFIAYGPKFKYNTEVQPFENIEIYNLMCDLLGIEPAANNGSHGSLNHLLKKPVYEPSLPKELFQCSVAFGCSCNLPSLTEAAFAHLILTPEQESDTKRLNLPFGRPVVLQ-YCILYQKYVSGYSYNIKMPLWSSYTIGKNEFVSLDKNSLCLFMDARVPPGQSQRCQYYHHHPSLKFGFFFPASLRKTSTSYSGLTTSNIGPMYPAFKVIWDYFQNVILLKYASEKNGVNVISGPIFDYDFDGQSDGFEQIQ---QMSKDTDVYIPTHYYIILTSCKNSSESLLLCLDVISYVVPHRTENSESCADDKDESLWVEQLLRFHAARVRDVELLAALSFFHNTKYSVSELLQFKTFIPDYL---
PhyML tree of selected proteins (XP_797859_4_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_5__Strongylocentrotus_purpuratus_:1.01985174,XP_038076960_1_bis_5__adenosyl__triphosphatase_enpp4_like__Patiria_miniata_:0.90921766,(XP_031562620_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_5_like_isoform_X3__Actinia_tenebrosa_:0.65170568,(XP_039259773_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_5_like__Styela_clava_:1.12948015,(XP_006560637_2_bis_5__adenosyl__triphosphatase_enpp4_isoform_X1__Apis_mellifera_:2.22446098,(CAE1329719_1_ENPP1_3__Sepia_pharaonis_:1.4255533,(NP_001129885_1_Ectonucleotide_pyrophosphatase_phosphodiesterase_C27A7_1__Caenorhabditis_elegans_:2.52301472,(XP_010707567_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_2_isoform_X6__Meleagris_gallopavo_:0.71507692,((tr_B0JZL7_B0JZL7_DANRE_Ectonucleotide_pyrophosphatase_phosphodiesterase_1_OS_Danio_rerio_OX_7955_GN_enpp1_PE_1_SV_1:0.31641375,(XP_030261662_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_like__Sparus_aurata_:0.15011674,(XP_015802949_1_PREDICTED__ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_like__Nothobranchius_furzeri_:0.24752664,XP_023808792_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Oryzias_latipes_:0.26597439):0.0959525):0.22784978):0.26044984,((((XP_006264801_3_PREDICTED__ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Alligator_mississippiensis_:0.00614658,XP_025068225_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Alligator_sinensis_:0.02937627):0.14037081,(XP_004940275_3_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_isoform_X1__Gallus_gallus_:0.06410687,XP_013224783_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Columba_livia_:0.06625602):0.10834121):0.11555003,((NP_032839_3_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_isoform_2__Mus_musculus_:0.02549558,NP_445987_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Rattus_norvegicus_:0.04303178):0.15957525,((NP_001076211_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Oryctolagus_cuniculus_:0.06679866,(XP_024104684_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Pongo_abelii_:0.01240964,(NP_006199_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Homo_sapiens_:0.00239175,(XP_018885608_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Gorilla_gorilla_gorilla_:0.00476125,(XP_003827708_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Pan_paniscus_:0.00118991,XP_016811798_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Pan_troglodytes_:0.00239395):0.00242757):0.00123403):0.00369786):0.04391887):0.01476171,((XP_003638833_2_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Canis_lupus_familiaris_:0.04355113,XP_023110144_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Felis_catus_:0.05404865):0.02562858,(XP_020943592_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_isoform_X1__Sus_scrofa_:0.02997194,((NP_001193141_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Bos_taurus_:0.02643814,(XP_004011375_4_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Ovis_aries_:0.00272555,XP_017909005_1_PREDICTED__ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Capra_hircus_:0.107086):0.01482979):0.00615618,(XP_020738141_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Odocoileus_virginianus_texanus_:0.02718453,((KAB0356465_1_hypothetical_protein_FD754_000621__Muntiacus_muntjak_:0.00129648,KAB0379402_1_hypothetical_protein_FD755_007186__Muntiacus_reevesi_:0.00000001):0.00391103,(KAF4024570_1_hypothetical_protein_G4228_016567__Cervus_hanglu_yarkandensis_:0.00583736,XP_043313008_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Cervus_canadensis_:0.00000001):0.00739515):0.00243083):0.00595126):0.03412615):0.01140331):0.0243592):0.02572724):0.24740819):0.09499883,(XP_018118655_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1_isoform_X1__Xenopus_laevis_:0.18223386,XP_040206375_1_ectonucleotide_pyrophosphatase_phosphodiesterase_family_member_1__Rana_temporaria_:0.23059152):0.1997439):0.15683423):0.14369345):0.65797022):0.18493359):0.70771652):0.42346316):0.10230827):0.28354287);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)