PB0035

DATABASE

Click here to access PB0035 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0035	P04070	Vitamin K-dependent protein C	PROC	APC, PC, PROC1, THPH3, THPH4, protein C, inactivator of coagulation factors Va and VIIIa	Homo_sapiens	Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845).

Domains

Gene Ontology

PF00008 (EGF) PF00089 (Trypsin) PF00594 (Gla)

GO:0004252 (enables) serine-type endopeptidase activity GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0008233 (enables) peptidase activity GO:0008236 (enables) serine-type peptidase activity GO:0016787 (enables) hydrolase activity GO:0006508 (involved in) proteolysis GO:0007596 (involved in) blood coagulation GO:0007599 (involved in) hemostasis GO:0030195 (involved in) negative regulation of blood coagulation GO:0043066 (involved in) negative regulation of apoptotic process GO:0050728 (involved in) negative regulation of inflammatory response GO:0050819 (involved in) negative regulation of coagulation GO:1903142 (involved in) positive regulation of establishment of endothelial barrier GO:0005615 (is active in) extracellular space GO:0005576 (located in) extracellular region GO:0005783 (located in) endoplasmic reticulum GO:0005788 (located in) endoplasmic reticulum lumen GO:0005794 (located in) Golgi apparatus GO:0005796 (located in) Golgi lumen

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P04070|PROC_HUMAN Vitamin K-dependent protein C OS=Homo sapiens OX=9606 GN=PROC PE=1 SV=1 MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECI EEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSC DCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVK FPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGA VLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDI ALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVL NFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP >tr|A8KC28|A8KC28_DANRE Proc protein OS=Danio rerio OX=7955 GN=proca PE=2 SV=1 MRSLFFCALTLVVFCSDGALCKSVFSSSPNAHMLLRSRRANTFMEELKPASLERECREEL CDFEEAREIFITREATLEFWTAYKDGNQCTTNPCVHGKCVDLLQDFSCTCDSGFEGKHCD LRRTATNCSLNNGDCDHDCHESKDGLARTCSCIKGYQLQDNSRKCAPKNDASCGQIRIPK SAYANKPKPVLQPWVMGGNVGKRGESPWQALILNHLGRFHCGGVLIDENWVLTAAHCLET SSKFSVRLGDYQRFRFEGSEVTLPVKQHISHPQYNPITVDNDIALLRLEGPVKFSTYILP ACLPSLELAKRMLHRNGTVTVITGWGKNNQSATSYNSTLHYVELPIVDNKECSRHMMNNL SDNMLCAGVLGQVKDACEGDSGGPMMTLFHDTWFLVGLVSWGEGCGQRDKLGIYTKVASY LDWIDSVRQGWDKV >tr|B8JLG2|B8JLG2_DANRE Protein C (inactivator of coagulation factors Va and VIIIa), a OS=Danio rerio OX=7955 GN=proca PE=4 SV=1 MRSLFFCALTLVVFCSDGALCKSVFSSSPNAHMLLRSRRANTFMEELKPASLERECREEL CDFEEAREIFITREATLEFWTAYKDGNQCTTNPCVHGKCVDLLQDFSCTCDSGFEGKHCD LRRTATNCSLNNGDCDHDCHESKDGLARTCSCIKGYQLQDNSRKCTPKNDASCGQIRIQK SAYLQPCGFAYRVGKRGKSPWQALILNNLGRFHCGGVLIDENWVLTAAHCLETSSKFSVR LGDYQRFRFEGSEITLPVKQHISHPQYNPITVDNDIALLRLEVPAKFSTYILPACLPSLE LAERMLHRNGTVTVITGWGKDNQSATSYNSMLNYVELPIVDNKECSRHMMNNLSDNMLCA GVLGQVKDACEVDSGGPMMTLFHHTWFLVGLVSWGEGCGQRDKLGIYTKVASYLDWIDSV RQGWDKV
Selected proteins from model organisms >NP_000303.1 vitamin K-dependent protein C isoform 10 preproprotein [Homo sapiens] MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAK EIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNC SLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDP RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDL DIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLV SWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP >NP_032960.3 vitamin K-dependent protein C isoform 1 [Mus musculus] MALPGRNCSFSLAHACVSSSRMWQFRVFLLLMSTWGISSIPAHPDPVFSSSEHAHQVLRVRRANSFLEEM RPGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSAPPLDHQCDSPCCGHGTCIDGIGSFSC SCDKGWEGKFCQQELRFQDCRVNNGGCLHYCLEESNGRRCACAPGYELADDHMRCKSTVNFPCGKLGRWI EKKRKILKRDTDLEDELEPDPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCVEGTK KLTVRLGEYDLRRRDHWELDLDIKEILVHPNYTRSSSDNDIALLRLAQPATLSKTIVPICLPNNGLAQEL TQAGQETVVTGWGYQSDRIKDGRRNRTFILTFIRIPLVARNECVEVMKNVVSENMLCAGIIGDTRDACDG DSGGPMVVFFRGTWFLVGLVSWGEGCGHTNNYGIYTKVGSYLKWIHSYIGEKGVSLKSQKL >XP_043316230.1 vitamin K-dependent protein C isoform X1 [Cervus canadensis] MASGGQPCSFSVAHPRDRGAVRGLAQQPCPGAGIRSDLVTRPLNQTGGCSFRMWQLTSLLLFVTVWGISSTPAPPDSVFS SSQRAHQVLRIRKRANSFLEELRPGSVERECSEEVCDFEEAREIFQNKEDTVAFWSKYSDGDQCEHRPSGSPCELPCCGR GKCIDGLGGFRCDCAEGWEGRFCLHEVRFSNCSADNGGCAHYCREEEGRRHCSCAPGYRLEDDHQLCEAKVTFPCGRLGK RMEKKRKTLKRDTNQVEQKDQLGPRIVNGQEAGWGESPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENRKKLIVRLG EYDMRRWESWEVDLDIKEVIIHPNYTKSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD EVKKNRTFVLNFIKVPVVPYNACVHAMENKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRLY NYGVYTKVSRYLDWIYGHIKAEEAPLESHVP >KAB0362964.1 hypothetical protein FD754_007120 [Muntiacus muntjak] MAAGGQPCSFSVAHPSGCSFRMWQLTSLLLFVTVWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGSVEREC SEEVCDFEEAREIFQNKEDTVAFWSKYSDGDQCEHRPPGSPCELPCCGRGKCIDGLGGFRCDCAEGWEGRFCLQEVRFSN CSADNGGCAHYCREEAGRRHCSCAPGYRLEDDHQLCEAKVTFPCGRLGKRMEKKRKTLKRDTNQVEQKDQLGPRIVNGQE AGWGESPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNYTKSTSD NDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDEVKKNRSSVLNFIKVPVVPYNACVHAMENKI SENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESQVP >KAB0379809.1 hypothetical protein FD755_007593 [Muntiacus reevesi] MAAGGQPCSFSVAHPSGCSFRMWQLTSLLLFMTVWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGSVEREC SEEVCDFEEAREIFQNKEDTVAFWSKYSDGDQCEHRPPGSPCELPCCGRGKCIDGLGGFRCDCAEGWEGRFCLQEVRFSN CSADNGGCAHYCREEAGRRHCSCAPGYRLEDDHQLCEAKVTFPCGRLGKRMEKKRKTLKRDTNQVEQKDQLGPRIVNGQE AGWGESPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNYTKSTSD NDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDEVKKNRSSVLNFIKVPVVPYNACVHAMENKI SENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESQVP >KAF4026284.1 hypothetical protein G4228_018405 [Cervus hanglu yarkandensis] MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRDSVFSSSQRAHQVLRIRKRANSFLEELRPGSVERE CSEEVCDFEEAREIFQNKEDTVAFWSKYSDGDQCEHRPSGSPCELPCCGRGKCIDGLGGFRCDCAEGWEGRFCLHEVRFS NCSADNGGCAHYCREEEGRRHCSCAPGYRLEDDHQLCEAKVTFPCGRLGKRMEKKRKTLKRDTNQVEQKDQLGPRIVNGQ EAGWGESPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNYTKSTS DNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDEVKKNRTFVLNFIKVPVVPYNACVHAMENK ISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESHV P >NP_001080424.1 protein C, inactivator of coagulation factors Va and VIIIa S homeolog precursor [Xenopus laevis] MNCLPFYRIWWLLIFHLILVIWVSPNAESSPVFSSRQEANHVLKVRKRAFNFMEELKPGSLERECIEEKCDFEEAFEIFE TKEDTLNFWAKYFDGDQCQSNPCVNAECKDGIGRFDCICNEGWEGRLCGYEVVYSNCSLNNGGCSHFCTQPMNSTRRVCS CATGYKLDEDHHTCQPVVEFPCGKSKIVDYDYNARLIGAKQGRKGDTPWQAMLRYEKKMKCGGVLIHPSWVLTAAHCVTY TGKYSVRLGEYDIRKLEDTEQQFAVVKIIIHPEYRSDTNDNDIALLRLVQPVVYNKYILPICLPSLDLAENTLMVNGTVV VVSGWGREDEKALNFSSVLSYIQIPVVSHNQCAETLNDRLSDNMLCAGRLGHIQDACYGDSGGPMVTKYGGSWFLLGLVS WGEGCGRINNFGVYTKVNRYLDWITQKIEDEEARRLSEVSQAEKQNINKSRKARP >OWJ99811.1 PROC [Cervus elaphus hippelaphus] MRRWESWEVDLDIKEVIIHPNYTKSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDEVK KNRTFVLNFIKVPVVPYNACVHAMENKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRLYNYG VYTKVSRYLDWIYGHIKAEEAPLESHTHFKRILGLQPRPCDRVSTSPK >XP_010726793.1 coagulation factor VII [Meleagris gallopavo] MVSRQCMALLLCFPLLVPPSLEAVFLKQEEANSIFQRHRRANSFFEEIKLGSLERECIEEKCSFEEAREIYRDDERTKEF WHIYSDPNQCDSSPCQNGGSCDDQFQDYVCRCPPEYEGKSCETAVDKNLKCIYDNGGCEQYCADQQSEKRVCFCAEGYTL ASDGVSCIPQVKYPCGKIPVLAKKNATAQGRIVGGVTCPPGECPWQALIIQDQKGKCGGSLLSPEWVVTAAHCLDYTHPK QLRVRLGEYSTKVDEKTEQESGVSKVIRHEEYTNGQVNHDIALLKLETPVNLTDFVVPICLPEKRFAVYELSSIKFSTVS GWGRLLDGGATSTFLMRVDLPRVKTQECEKQANLNITENMFCAGDLTGKKDSCKGDSGGPHATKYKNTWFLTGIVSWGKG CAVEGSYGVYTRVSRYIDWLKRYME >XP_038049155.1 transmembrane protease serine 9-like isoform X3 [Patiria miniata] MWRPRVTRIARYVAVSHDPIECGVPRIRGKIIGGKTTEEGQAPWMALLWNTKENTHFCGGVLLNQRWVITAAHCFARYKY DIKEHMEVRLGEYDLFKEEGTERILQVEQLIVNPEFDKDTYDSDIALLKLRQPVTYTDFIVPICLPSEMRAMNLLQARTR GFITGWGRTAEITTTTTRYLRRVRLLVMDQQTCNNRHQDVITNRMFCAMSDDRPTARDSCFGDSGSPFAVRDNKRWFLIG LVSWGIGCARHRFPGVYTRVHRYTHWITSLIGDDTDTCAGLQERVSELTSQLSQEEEEIKQLREQLQEKDRQLNESLSCS TQTTNLPSTTSGTTQPSVDLRRSTPPLELRIPCRQGSCAHVGGFQVRAVCEDDFCSCESPYYSRESCLPLYGSCVIKHDA PSATARPSYQDEAQQTYSCLANDNPKYRVYVLAVHEGNRHTRPPVAGDMEVALDGNAPQEGARGFVLVLASYEPVNWSIR LIGQLVMDQVILIAHFPSTVTIAGPYGELRTDIPVLTSADPCGYGNDSGGGGDTPGMLGVINETVGPVESFTGTYRADKW LLNVDEGLHLRDPD >XP_031567558.1 CUB and peptidase domain-containing protein 2-like [Actinia tenebrosa] MDRLSTETLLLLLLATCIRIQAFSCNFDKDSCGFTQRADDDFNWRRYQWGTPSQGTGPNSDHTTERGYYMYVEASGKKEG KKAVLERNVDISGENTCLTFYYHMNGRHVGKLNVYVGSNKVFSKTASQGDGWKMAKVSLLGANRGKQMLKLEGIVGRGFL GDIAIDDVSVGLCNEEGTIPPPFPSATTPIVVLPTTMRPSPPIPPSGSCGIRPKTRIVGGTSSQHGDWPWQAQLKSSPGS SPFCGGSLIHPQWILTASHCVSGSKAIKTIVRLGAHRRSVKVGTEQDFKIIKVITHPSYHKPISYSNDIALLKLEKPAKL NRYVNLVCLPDSVSLPSDGTKCWITGWGRTHGPSPDYLQQASVPIVSENRCRFAYLGXIHDSMMCAGLDRGGIDSCQGDS GGPMVCENGGRFYVQGATSWGNGCGRPGKFGVYAKVKYQLDWIHSEIKKG >XP_030830576.1 uncharacterized protein LOC100887833 [Strongylocentrotus purpuratus] MHFLDAWFPAGVLIIVCCLLSRSVAQLIDPEIRNITASAGDDVLLDCVPPDGEALLISWNKDNDVVQITDAYRDGRIFLD QKEGMVILNSELWDRGMYSCLILTQDSQIITHRFWLDIAPPTDSDVDSNSAFQCGYCRVRGKVVGGKVSNEGQSPWTALL WNTNEGKPLCGGVLLNRRWVVTASHCFSLSGLSIDEFEIRLGEHDIEAISDNERTFRAEQIIKHPNFNEQTYDSDIALIK LQQPVTYTDYIIPLCLPSELRADELLKAETRGFVTGWGNTEEAGDYSRYLRRVRLTIASMQDCGRSHIDIITNNMFCADG GRKADERDACQGDSGGPFVTKDNNRWYLLGIVSWGVGCARPGYPGVYTRVHRFRQWIMDLVQQDMQTCEESSFELGEELR ASVKESNNLRLLNQEQQHLIEYFQEELNRKDEEIFDLHERIETFDCPDGLPTSTSPPESTTPTMTNYPVITETRPVTTRA PIQEDALPCRHNMCWHVSNLARCHGGYCVCDSPDYSRVSCLPIVGSCRIYRNNSYALATATFRDDTRIADTFACEGNPES NVHIISVYEGPVHTRPASPGDVHVRVTGGDQGPITIVFSSYEPVRWLVSVDEGIMINKFVLTGYYLDLSSVEVVSLLHTN VTVVTVSRVPFGYGTDGDGVLHTAEFLKYVQNTYGDVGSFSGTYRADRWVLTVPGEAPIVDWMRLPLPIIPMARVESTLS RTGWTPFPFRYDGSFCACHGDQYVKLLGGSENELDYGVRYVGVVLCQTPSHYKIFLANDLEETFLNVGDGSGGGSDHCEF VGGHHENETLAQTSRDWLLMPAVSGYYRSVWGEPVSFGSIGGGYRTWTGKIIVSWYDCGITIP >XP_006557877.1 serine proteinase stubble isoform X6 [Apis mellifera] MNWLASLFLILFYIGFYCQAENRKNDRYLKNFDLDTKKETAMENVIDSKGQSRFFDELGLIPQTCTYKGTTFDCGLSISC VLGGGRPVDLCSGGLIWSCCVDDDDIPDKVPRPTIGLLQNASCGELYTRSNRIVGGHSSSFGSHPWQAAIIKSGFLTKKL SCGGALLNNRWVVTAAHCVATTPNGNLKVRLGEWDVRDASEQLLHEEFNVERKEVHPQYSPTDFRNDVALVKLSRTVAFK QHIVPVCLPAKNLKISGRTATVAGWGRTRHGQSSAPTILQEVDVEVIPNERCQRWFRAAGRRETIHDVFLCAGYKEGGRD SCQGDSGGPLTMSVEGRHVLIGLVSWGIGCGREHLPGVYTNIQKFVPWIDKVMS >NP_001097592.1 uncharacterized protein Dmel_CG10663, isoform B [Drosophila melanogaster] MKVVCWVLEFLTVVQLLIETQSGYVQEAKREIWDAMAHHRHRHHQHYHHGSSHWIDGRRVHRLRMPHPQRWSGRRRSLNQ HQPFSRWSQWSPCDEECVRRRERFCKVKRKCGHTKHVEQSKCSHCHPAPAIKWQPPLILDDSHIRERIQPLPQPQPQPPP PPPPSIIINAAAAASSGPTVDYRYTEYKPPPNYASLYPSTHPPIYTPTYPAAHPPTQPPTYPPPTHPPTPPPTPPTNPDE VVRHLPKYPGKDIFSEEDVEDELEPEPDEDLISSDEQGDFFVLKHHRHRRRQNHRRPSHRKPPKEEDYDDSDFVDFGERK SLRHRHLGEDSSVEGDVFQYEDFDLPDTMYADSQESEGEFRNITWMQPAKDGIALRRRKVYSKWSRWTKCSPKCTTRRYK KCRIMDQCGREVLREIAYCYTEGSFCQQWLQTQFQKTPAFETRPGSGSPANAMRRMQSEQPEVSMNDLNYIMTGKGYRGP EYTPLKLSCGIVRSGTGRRSMSNMLKIIGGRAARKGEWPWQVAILNRFKEAFCGGTLIAPRWVLTAAHCVRKVLFVRIGE HNLNYEDGTEIQLRVMKSYTHPNFDKRTVDSDVALLRLPKAVNATTWIGYSCLPQPFQALPKNVDCTIIGWGKRRNRDAT GTSVLHKATVPIIPMQNCRKVYYDYTITKNMFCAGHQKGHIDTCAGDSGGPLLCRDTTKPNHPWTIFGITSFGDGCAQRN KFGIYAKVPNYVDWVWSVVNCDGNCKMH >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MRRIYFFHGICLVLFSFTSSFLSLSLSLSLSLSRSLFLSRFLSLSSSLRRRGRHLISRGSHKYTASSNMSQVDHEGNIIP KRKQSGSSTVMCEHYSAWATWSHCSRRCEQYRTRNCVEPRYCGNTTIKDKRFCKRRNKQCSILSFKVITPLRRAKEVQQI ITNAFYNKWTAWSPCSRDCKQKRKRQCRSRWKNVCGESYIQQTRKCRPVAGTCEKKYTLSVLVADEPAETKKGPTSNRHN KAITNCTAELAMPDKCGTRPSGSQRNYRIVGGYEVRRHSWPWQVAILTRAKKQYCGGTLISPQWVLTAAHCVRKRGRKRK VIVRMGEHDLHSRSGNEITLELEKDFPHPKFDFHTISNDIALLKLKRPVRRSFNVGFACLPTETNELHAGTICNIIGWGK VDGSHQDGAKILREAEVPVVDQGKCQKAFKYKITNNQICAGFKGGGVDSCGGDSGGPLICANHPNRTTQWANRNAVSVLD ADFSFSPSLFMH >NP_501379.2 Serine protease svh-1 [Caenorhabditis elegans] MYIVIVTMRTILFFGIFFIFIFQCAKCIELKIFEDLLEVRSQSGLFFPLCSKSFHQKYGEQACASISSTFLSYSTVSLQQ YTYSVGCTTSVCFTFLSSFCKTGVKVFCSPSLCASGTLQIGSKCLSISTVPVQGYSEANYYCNPATLISSLKPTEIESIR DTILPTFADTRLFLTSGLRQGATWKWGNGDTVEQEVTGTGRCLALQAGNLVAIDCDSEAYVFCESGRECIARDKEYSGTA NRTSDGKMCLMWNDPTVLFRRERDLEILNHNFCRFVNDADGKKSATPVCYTKPNELSQCYIPPCPESFNDVVPIESGDSC PIGSISCDNGSKCISEKFQCDYEVDCNDGSDEHNCEDYLQYYELIGAYRLADNIIEVWTFIPHVQGCARKCRESLLMCEA FSYEPKSQTCLLTDTSQTFSSLARKITSLYYRRRFSTKDVEFQVENKVLYATKSAKKGHVCDDNYSREKLSSICRVLGFG DPIYTVESHQSESSLGPLQPTTLHPTNPSFDSPSSVSQMRRTSPSATLAPRLPAWNLSCLREPNCTSTVISTCEPIRCSH CQQAACGDGSCIRFDQLCNGQIDCQSGEDEDYCRANSFRLTNGSDTSGYLEVLFRSRWEPICADHLNGKISNSICDAMRL GEHGFILSTNATISSGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRYVEVNARDAAKSRIARVVGGFETV PGAFPWTAALRNKATKAHHCGASILDKTHLITAAHCFEEDERVSSYEVVVGDWDNNQTDGNEQIFYLQRIHFYPLYKDIF SHDIAILEIPYPGIEFNEYAQPICLPSKDFVYTPGRQCVVSGWGSMGLRYAERLQAALIPIINRFDCVNSSQIYSSMSRS AFCAGYLEGGIDSCQGDSGGPFACRREDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAIINGQPV >XP_008770240.3 vitamin K-dependent protein C isoform X1 [Rattus norvegicus] MLRAILKAGTPLLSSTCSLRWNINSGNQQRQRTGVSSSRMWQFRIFLLFASTWGISGVSAHPDPVFSSSE GAHQVLRVRRANSFLEEVRAGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSTPPLDHQCD SPCCGHGTCIDGLGGFSCSCDKGWEGRFCQQEMGFQDCRVKNGGCYHYCLEETRGRRCACAPGYELADDH MHCRPTVNFPCGKLWKRTDKKRKNFKRDIDPEDEELELGPRIVNGTLTKQGDSPWQAILLDSKKKLACGG VLIHTSWVLTAAHCLESSKKLTVRLGEYDLRRRDPWELDLDIKEVLVHPNYTRSNSDNDIALLRLSQPAT LSKTIVPICLPNSGLAQELSQAGQETVVTGWGYQSDKVKDGRRNRTFILTFIRIPLAARNDCMQVMNNVV SENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGE RDVSLKSPKL >XP_024854240.1 vitamin K-dependent protein C isoform X1 [Bos taurus] MAAGGQPCSFSAAHPKPDKAEIQFSHPFYKRGDGGAVRGLAQQPCPGAGIRSDLVTRPLNQTGGCSFRMW QLTSLLLFVTIWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGNVERECSEEVCEFEEAREI FQNTEDTMAFWSKYSDGDQCEDRPSGSPCDLPCCGRGKCIDGLGGFRCDCAEGWEGRFCLHEVRFSNCSA ENGGCAHYCMEEEGRRHCSCAPGYRLEDDHQLCVSKVTFPCGRLGKRMEKKRKTLKRDTNQVDQKDQLDP RIVDGQEAGWGESPWQAVLLDSKKKLVCGAVLIHVSWVLTVAHCLDSRKKLIVRLGEYDMRRWESWEVDL DIKEVIIHPNYTKSTSDNDIALLRLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKR NRTFVLSFIKVPVVPYNACVHAMENKISENMLCAGILGDPRDACEGDSGGPMVTFFRGTWFLVGLVSWGE GCGRLYNYGVYTKVSRYLDWIYGHIKAQEAPLESQVP >XP_015132295.2 vitamin K-dependent protein C isoform X1 [Gallus gallus] MARGGAGVDRECSGRAAGDFCCSMWKLITIGVLLAACSSPVCHASIFYSYKDANQVLKIRKRANSFLEEL KPGSVERECNEERCNFEEASEIFETKEATLEFWSKYVDGDQCAQKPCSNGACKDNIGSYSCICDKGWEGA QCNYEVKYNNCSVDNGGCQHFCKEDPAKQCRYCSCASGYQLTNDHNMCTPVVEFPCGRVKMDYTEGKAEF NIRLIGGNSGGRGFSPWQVMLQNLKGKFLCGGVLIHPSWVLTAAHCVETGETLKVRLGKYHRLRIENSEQ TIRVDKYVRHENYTKLTSDNDIAMLHLAEPVMYNKYALPICLPTRDLAEHELTTKGRQMLVTGWGSTSDE MRNYSALLSYIEIPIVPKNECAQVMTNTISDNMLCAGSLGDRKDSCSGDSGGPMATKYKDTWFLVGLVSW GEGCGKKEKFGVYTKVSQYLEWIQHHINKKSGSWRG >XP_020930330.1 vitamin K-dependent protein C isoform X1 [Sus scrofa] MAVRGQPCSFSAAHSSGSNSRMWQLASLLLLLIIWAVSSTPVPPDSVFSSSQRAHQMLRSKRANSFLEEL RPSSLERECKEETCDFEEAREIFQNTENTMAFWSKYHGECTPDPWPRCPCSSGSLGHCGYGEGRDPAAPV TPSSPHVADGDQCAVSPPEHLCDSPCCGRGTCIDGLGGFRCDCAQGWEGRFCLHEVRFSNCSTENGGCAH YCLEEEGGRRCRCAPGYRLGDDHLQCEPKVKFPCGRLGNRMEKKRKSLKRDTDQVDKKEDQIDPRLVNGK QSPWGESPWQVILLDSKKKLACGAVLIHVSWVLTAAHCLDDYKKLTVRLGEYDLRRREKWEVDLDIKEFL VHPNYTRSTSDNDIALLRLAEPATFSQTIVPICLPDSGLSERELTRVGQETVVTGWGYRSEAKTNRSFIL NFIKVPVAPHNECVQAMHNKISENMLCAGILGDSRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRLH NYGVYTKVSRYLDWIHGHIRMEEAFHKNQVP >XP_009441514.3 vitamin K-dependent protein C isoform X1 [Pan troglodytes] MRPHLSRVLPSPPSPLDGILGGQRWASGRPSRAELGPGVLVPLFVYGEGGLSAEGQANICGYGLTRTPGC HGGRTANLQYLHNPPLQSSSGGRHCPELRSPPQTGASASRMWQLTSLLLFVATWGISGTPAPLDSVFSSS ERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHP CASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQRGEGESGALAGGGAGLGPGWGRGTSTSCPRPPLPAEVS FLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCQPAVKFPCGRPWKRMEKKRSHLKRDTEDQED QVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKW ELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHS SREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFL VGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP >XP_038281494.1 vitamin K-dependent protein C isoform X1 [Canis lupus familiaris] MAVGQQPSTFFPAHPSSRQNRSWWGCWKLRSPPQTGVSNSRMWQLASLSLLLTICGTCSTAAPPGSVFSS SESAHQVLRIRKRANSFLEEIRAGSLERECMEEICDFEEAKEIFQNVDDTLAYWSKYVDGDQCAALPPEH ACDSPCCGHGSCIDGIGAFHCDCGRGWEGRFCQHGEGGAAGRGGGGQEGGGGGSAVPPALLLLLPPIHPE VSYINCSLDNGGCSHYCLEEEGGRHCSCAPGYRLGDDHLQCQPAVKFPCGRPGKQMEKKRKHLKRDTNQT DQIDPRLVNGKVTRRGESPWQVVLLDSKKKLACGAVLIHTSWVLTAAHCMEDSKKLIVRLGEYDLRRWEK GEMDVDIKEVLIHPNYSKSTTDNDIALLHLAQPAIFSQTIVPICLPDSGLAERELTQVGQETVVTGWGYR SETKRNRTFVLNFINIPVAPHNECIQAMYNMISENMLCAGILGDSRDACEGDSGGPMVTSFRGTWFLVGL VSWGEGCGRLHNYGIYTKVSRYLDWIHSHIRGEEASLENQVP >XP_008256638.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Oryctolagus cuniculus] MAAGRRTCGFSRAHPCASNSRMWQLAGLLLFVATWGTSSTPAPPDSVFTSREHAHHVLRIRKRANSFLEE LRPSSLERECVEEVCDLEEAKEIFQSVDDTLAFWYKYVDGDQCAALPSEHPCSSQCCGHGTCADSIGGFS CQCHGGWEGSFCQYEVRFSNCSVDNGGCAHYCLEEEAGRSCSCAPGYELADDHLQCEPAVRFPCGRLGWK RIEKKRGNVKRDLEQVDEMDEVDPRLIDGKLTRRGDSPWQVILLDSKKKLACGAVLIHVSWVLTAAHCME EPKKLFVRLGEYDLRRKERWELDLNIQEVLIHPNYSRSTTDNDIALLRLAQPATLSQTIVPICLPDNGLA ERELMQAGQETVVTGWGYHSSREKEAKRNRTFILNFITVPVAPQNECEQVMSNIISENMLCAGILGDRRD ACDGDSGGPMVASFRGTWFLVGLVSWGEGCGDLNNYGVYTKVSRYLDWIHSHIEEKEAAPESPAP >XP_024099270.1 vitamin K-dependent protein C isoform X1 [Pongo abelii] MWRLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRPSSLERECIEEICDFEEAK EIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASPCCGHGTCIDGIGSFSCDCRSGWEGRFCQRGEGERGA RAGGGAGLGQGWGRGTSASCPRPPLPAEVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCQ PAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPS WVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIEEVFVHPNYSKSTTDNDIALLRLAQPATLSQTIV PICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENML CAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWVHGHIRAKEAPR KSWAP >XP_034810124.1 vitamin K-dependent protein C isoform X1 [Pan paniscus] MAAGRRTCSISTTRPCRAAAGVGTARSSEVLLRQVPAPPECGSSQASCCSWPPGEFPVHQLLLVLRIRKR ANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCI DGIGSFSCDCRSGWEGRFCQRGEGESGALAGGGAGLGPGWGRGTSTSCPRPPLPAEVSFLNCSLDNGGCT HYCLEEVGWRRCSCAPGYKLGDDLLQCQPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQIDPRLIDGKMT RRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVH PNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTF VLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGL LHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP >XP_023114975.1 vitamin K-dependent protein C isoform X1 [Felis catus] MAAGRRPCNFSLAHPSVSNFRMWQLSSLFLLVTIWGTSATPAPPDSDAFLSWPLHQPLRPLFLTSLTWSF HPSCPQQTPLRALETDSVFSSRELSHRVLRIRKRANTFLEELRAGSLERECVEEICDLEEAQEIFQNVDD TLAFWAKYIDEDQCAAPPPDHPCDSPCCGHGNCIDGISAFRCDCDPGWEGRFCLYEVSFSNCSLDNGGCA HYCLEEEGGRRCSCAPGYKLGDDHLQCEPTVKFPCGRPGRRMEKKRKTVKRDTSQADQIDPRLVNGKLSG WGESPWQVILLDSKKKLACGAVLIHTSWVLTAAHCMEDSKKLMVRLGEYDLRRREKWELDLDIKEVLMHP NYSRSTSDNDIALLRLAQPAILSQTIVPICLPDSGLAERELTQAGQETVVTGWGHRSEAKRNRTFVLNFI KVPVVPQNECINAMHNMISENMLCAGILGDSQDACEGDSGGPMVASFRGTSFLVGLVSWGEGCGRLHNYG VYTKVSRYLDWIHSHIRAEEASLEGQVP >XP_018878397.1 vitamin K-dependent protein C isoform X1 [Gorilla gorilla gorilla] MAAGRRTCSISTTRPCASASRMWRLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEE LRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFS CDCRSGWEGRFCQRGEGERGARAGGGAGLGPGWGRGTSASCPRPPLPAEVSFLNCSLDNGGCTHYCLEEV GWRRCSCAPGYKLGDDLLQCQPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPW QVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKST TDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKI PVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVY TKVSRYLDWIHGHIRDKEAPRKSWAP >XP_004078808.1 vitamin K-dependent protein C [Oryzias latipes] MSRLVLCLIVCVTLWSASVVSLSVFSDAPQAHMLLRSRRANSFLEEMKPPSKERECIEEKCDFEEAREIF LTREATLEFWTVYTDGNQCQSNLCVHGECVDLFQDYACRCNPGYEGKYCEYNVTATNCSVNNGDCDHDCI EGEDGQWRKCSCLNGYNLDKNNRKCLPQGTTSCGQLLISRSEYSEPLVGLLPWMLGGEVGKKGESPWQVV VLNARGNFHCGGVLINRNWVLTAAHCLENNLQFAVRLGDYELLRKEGTEVMLKVAKAFKHPNYNRETVDN DIALLRLVTPAPFNSYIAPICLPGRAMAERVLHLNGTTTVVTGWGKDDSGKYSSALNVIKVPLVSHSVCA QQMLPYTISENVLCAGILGQRIDACEGDSGGPMVTLYHGTWFLVGLVSWGEGCGQIDRLGIYTKVSNYND WIKQVQEEWDRTNNLQ >XP_005512774.1 vitamin K-dependent protein C [Columba livia] MWKFVTVGVLLAACSSRLCSTSIFYNNKDANQVLKIQKRANSFLEELKPGSLERECNEELCDFEEASEIF ETREATRDFWSKYVDGDQCEPQPCSNGICKDNIGKFSCICNKGWEGLLCNYEVKYTNCSVNNGGCDHFCR DDPANQCRYCSCASGYQLMNDHTMCKPVVEFPCGRVKMDYIEGKAEFNIRLIEGKVGRRGISPWQIMLQN SKGKFLCGGVLIHPSWVLTAAHCTEAEEGLKVRAGKFHRLRTEAEEQTIWVDKYVIHENYTKETSDNDIA MLHLAEPVMYNKYVLPICLPTRDLAEQELTRNRRQMVVTGWGSTSDVNNNYSTFLSYIEIPMVPRNECAQ AMRFAISDNMLCAGSLGDKKDSCSGDSGGPMITKYRDTWFLVGLVSWGEGCGRKEKFGVYTKVSQYLEWI QHHIDEMSASWKG >XP_017921293.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Capra hircus] MAAGGQPCSFSVAHPNSGHVTLALYREADGTVTGDPDPSSRPGDQHTHTQRRLVHSAPTTGGCGFRMWQL SSLLLFVTVWGIFSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEELRPGSVERECSEEVCEFEEAREIFQ NTEDTMAFWSKYSDGDQCEQRPSGSPCDLPCCGRGKCIDGLGGFRCDCAEGWEGRFCLHEVRFTNCSAEN GGCAHYCLEEAGRRHCSCAPGYRLQDDHQLCESKVTFPCGRLGKRMEKKRKTLKRDTNQVDQEDQLDPRI VSGQEARWGDSPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENHKKLIVRLGEYDMRRWESWEVDLDI KEVIVHPNYTKSTSDNDIALLHLAKPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKKNR TSILNFIKIPVVSYNACVHAMENKVSENMLCAGILGNSRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGC GRLYNYGIYTKVSRYLDWIYGHIKAEAALESQVP >XP_025065251.1 vitamin K-dependent protein C isoform X1 [Alligator sinensis] MLFTLSGVTSCTMWRFMTFSWTLLAACSFCLLEASVFYSREDANKVLKIQKRENSFLEELKAGSLERECN EESCDLEEAMEIFESREATLSFWTKYIDGDQCEKQPCNNGTCLDAIGGFNCICNRGWEGLLCQHEVLYTN CSICNGGCDHYCKEDPGNQRRYCSCALGYKLMEDYSQCLPDVEFPCGKVKVNVESKKDIHIRLINGKIGR KGDSPWQVMLSDGRGKFKCGGVLIHTAWVLTAAHCVEDDRRYKVKLGKYHRLRDEETEQIILVDKVVIHE NYTKADSDNDIAMLHLAKPMVFNKNALPICLPTKELAEQELTRSGKKMVVTGWGSKTEKTMNFSNVLNYI EIPLVPRNECVQVMRHDISENMLCAGIIGDQQDACGGDSGGPMITTFKNTSFLVGLVSWGEGCGKSEKFG VYTKVSQYLQWIQRQMKASENTSNN >XP_042099536.1 LOW QUALITY PROTEIN: vitamin K-dependent protein C [Ovis aries] MAAGGQACSFSVAHPSGCGFRMWQLSSLLLFVTVWGIFSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEE LRPGSVERECSEEVCEFEEAREIFQNTEDTMAFWSKYSDGDQCEQRPSGSPCDLPCCGRGKCIDGLGGFR CDCAEGWEGRFCLHGEGXGGGGAGASPGPGPAGRVEPRRPRGALRVCPEVRFTNCSAENGGCAHYCLEEA GRRHCSCAPGYRLQDDHQLCESKVTFPCGRLGKRMEKKRKTLKRDTNQVDQEDQLDPRIVSGQEARWGDS PWQAVLLDSKKKLVCGAVLIHVSWVLTVAHCLESHKKLIVRLGEYDMRRWESWEVDLDIKEVIVHPNYTK STSDNDIALLRLAKAATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDETKKNRTSILNFIKIPV VPYNACVHAMENKVSENMLCAGILGNSRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRLYNYGVYTK VSRYLDWIYGHIKAEAPLESQVP >XP_006261873.1 PREDICTED: vitamin K-dependent protein C [Alligator mississippiensis] MWRFMTFSWTLLVACSFCLLEASVFYSREDANKVLKIQKRENSFLEELKAGSLERECNEESCDLEEAMEI FESREATLSFWTKYIDGDQCEKQPCNNGTCLDAIGGFNCICNRGWEGLLCQHEVLYTNCSICNGGCDHYC KEDPGNQRRYCSCALGYKLMEDYSRCLPDVEFPCGKVKVNVESKKDIHIRLINGKIGRKGDSPWQVMLSD GRGKFKCGGVLIHTAWVLTAAHCVEDDRRYKVKLGKYHRLRDEETEQIILVDKVVIHENYTKADSDNDIA MLHLAKPMVFNKNALPICLPTKELAEQELTRSGKKMVVTGWGSKTEKTMNFSNVLNYIEIPLVPRNECVQ VMRHDISENMLCAGIIGDQQDACGGDSGGPMITTFKNTSFLVGLVSWGEGCGKSEKFGVYTKVSQYLQWI QRQMKASENTSNN >XP_015811969.1 PREDICTED: vitamin K-dependent protein C-like isoform X1 [Nothobranchius furzeri] MSRLMIFVCVCVAAWSALVISQSVFSDAPQAHMLLRSRRANSFLEELKPASMERECVEEDCDFEEAREIF QTREATLEFWTVYTDGNQCQSNMCVHGECVDQYQDYACRCRPGYEGKYCQYNITATNCSMNNGDCDHDCT ESENGLSRICSCVTGYRLENNYRKCVPKGSSACGQLLISRSEYANPQGGLMPWMLGGEVGKKGESPWQVL VLNARGSFHCGGVLIDKNWVLTAAHCLQNNHRFSVRLGDYERLITEDTEVKLEVSKAFKHPNYNSQTVDN DIALLRLRTPAPFSKYILPVCLPSRAMAERVLHQNGTVTVVTGWGRDDTGKYSSALNVIKVPLVDHSNCS RQMFPHQLSNNVLCAGILGERIDACEGDSGGPMVTLYQNTWFLVGLVSWGEGCGIKDKPGIYTKVSNYNR WISQVQEEWDRKHQPQRAPTV >XP_020745839.1 vitamin K-dependent protein C isoform X1 [Odocoileus virginianus texanus] MAAGGQPCSFSVAHSSGCSFRMWQLTSLLLFMTVWGISSTPAPPDSVFSSSQRAHQVLRIRKRANSFLEE LRPGSVERECSEEVCDFEEAREIFQNKEDTVAFWSKYSDGDQCEHRPSGSPCELPCCGRGKCIDGLGGFR CDCAEGWEGRFCLHGEGAWTGAVGRGPPGPEPAGRLEPPRPRGALLRVCPEVRFSNCSADNGGCAHYCRE EEGRRHCSCAPGYRLEDDHQLCEAKVTFPCGRLGKRMEKKRKTLKRDTNQVEQKDQLGPRIVNGQEAGWG ESPWQAVLLDSKKKLVCGAVLIHISWVLTVAHCLENRKKLIVRLGEYDMRRWESWEVDLDIKEVIIHPNY TKSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRDEVKKNRTSVLNFIKV PVVPYNACVHAMENKISENMLCAGILGDSRDACDGDSGGPMVALFRGTWFLVGLVSWGEGCGRLYNYGVY TKVSRYLDWIYGHIKAEEAPLESQVP >XP_030258505.1 vitamin K-dependent protein C [Sparus aurata] MSRLVLCVSVIVTLWSVSVLSLSVFSDPPEAHMLLRSRRANSFLEELKPASKERECIEERCDFEEAREIF QTREATLEFWTVYTDGNQCQSNMCVHGACVDQYQSYVCRCNHGYEGRYCDQLQTATNCSEDNGGCDHDCT ESEDGLTRSCSCVSGYKLHDDGRKCEAIGPSSCGQLLIARSSYTKQVEGPMPWTVGGEVGKKGESPWQVL LLNSRGTFHCGGVLIDESWVLTAAHCLEGNLRFSVRLGDYERIRIEDTEVTLRVVETFRHPNYYNRRAVV DNDIALLRLEHPAPFSNYILPVCLPGHEMAERVLHLNGTRTVVTGWGKEDPNKNRYSSALNVIKIPLVNH DVCSRQMSNNVSNNFLCAGILGQRMDACEGDSGGPMVTLYRDTWFLLGLVSWGEGCGRVDKLGIYTKVSN YYEWINKVREEWDRSHHPAEPQHV >tr|A8KC28|A8KC28_DANRE Proc protein OS=Danio rerio OX=7955 GN=proca PE=2 SV=1 MRSLFFCALTLVVFCSDGALCKSVFSSSPNAHMLLRSRRANTFMEELKPASLERECREEL CDFEEAREIFITREATLEFWTAYKDGNQCTTNPCVHGKCVDLLQDFSCTCDSGFEGKHCD LRRTATNCSLNNGDCDHDCHESKDGLARTCSCIKGYQLQDNSRKCAPKNDASCGQIRIPK SAYANKPKPVLQPWVMGGNVGKRGESPWQALILNHLGRFHCGGVLIDENWVLTAAHCLET SSKFSVRLGDYQRFRFEGSEVTLPVKQHISHPQYNPITVDNDIALLRLEGPVKFSTYILP ACLPSLELAKRMLHRNGTVTVITGWGKNNQSATSYNSTLHYVELPIVDNKECSRHMMNNL SDNMLCAGVLGQVKDACEGDSGGPMMTLFHDTWFLVGLVSWGEGCGQRDKLGIYTKVASY LDWIDSVRQGWDKV >tr|B8JLG2|B8JLG2_DANRE Protein C (inactivator of coagulation factors Va and VIIIa), a OS=Danio rerio OX=7955 GN=proca PE=4 SV=1 MRSLFFCALTLVVFCSDGALCKSVFSSSPNAHMLLRSRRANTFMEELKPASLERECREEL CDFEEAREIFITREATLEFWTAYKDGNQCTTNPCVHGKCVDLLQDFSCTCDSGFEGKHCD LRRTATNCSLNNGDCDHDCHESKDGLARTCSCIKGYQLQDNSRKCTPKNDASCGQIRIQK SAYLQPCGFAYRVGKRGKSPWQALILNNLGRFHCGGVLIDENWVLTAAHCLETSSKFSVR LGDYQRFRFEGSEITLPVKQHISHPQYNPITVDNDIALLRLEVPAKFSTYILPACLPSLE LAERMLHRNGTVTVITGWGKDNQSATSYNSMLNYVELPIVDNKECSRHMMNNLSDNMLCA GVLGQVKDACEVDSGGPMMTLFHHTWFLVGLVSWGEGCGQRDKLGIYTKVASYLDWIDSV RQGWDKV >XP_040204807.1 vitamin K-dependent protein C [Rana temporaria] MRYRFLCTMWWILLLSITSFTILPAYSSTIFYNSQDANRVLKVRKRANGFFEEMKPGSLERECYEERCDL EEANEIFETREETLNFWSKYFDGDQCLSNPCVNAVCKDGIGKFDCTCNGGWEGKFCAYEVTHHSCSLNNG GCTHFCTEIANDTSRTCSCATGYQLQDDGRSCKPNGDFPCGRSKIIDYDYSARLTGAKKGRKGDSPWQAL LVHGKKFFCGGVLIHPYWVLTAAHCFKGAPNDAKFYVRLGEYDRRILEDTEQQIAVTKLFPHPKFDPAEV NNDIALMRLNQAAVYNKYVLPICLPSYGLAERNLTLEGTETIVTGWGYQDQTYRNRTTILSYIQVPIVSQ NNCSDVMRGRITGNMLCAGTLGDSQDACSGDSGGPMVIRFGDTWFLAGLVSWGEGCGRLDNFGVYTKVHY YLDWIDQTMANYETELKKVKPSHKKKTER
Mafft alignment of selected proteins >NP_000303.1 vitamin K-dependent protein C isoform 10 preproprotein [Homo sapiens] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MWQLTSLLLFVATWG-I SGTPAPL----------------------------------------------------- ----------------DSVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRHSSL---------- -------------------------------------------------ERECI------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAFWSKH-----------------------------------------VDG-- -----DQCLVLPLEHPCASLCCGH-GTC--IDGIGSFSCDCRSGWEGRFCQR-------- ----------------------------EVSFL-------------NCSLDNGGCTHYCL EEVGW----RRCSCAPGYKLGDD-------LLQC------------HPAVKFPCGRPW-K RMEKKRSHLKRDTE----DQEDQVDPRLIDGKMTRRGDSPWQVVLLDS---KK-KLACGA VLIHPSWVLTAAHCMDES-----KKLLVRLGEYDLRRWEKW--ELDLDIKEVFVHPNY-- SKSTTDNDIALLHLAQP-ATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCA--GILGDRQDACEGDSG GPMVASF----HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >NP_032960.3 vitamin K-dependent protein C isoform 1 [Mus musculus] ------------------------------------------------------------ ---------------------------MALPG----RNCSFSLAHA-------------- -------------------------------------CVSSSRMWQFRVFLLLMSTWG-I SSIPAHP----------------------------------------------------- ----------------DPVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------HAHQ--------------VLRVR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEEMRPGSL---------- -------------------------------------------------ERECM------ ---------------EEIC-------------------DFEEAQEIFQN----------- ---VEDTLAFWIKY-----------------------------------------FDG-- -----DQCSAPPLDHQCDSPCCGH-GTC--IDGIGSFSCSCDKGWEGKFCQQ-------- ----------------------------ELRFQ-------------DCRVNNGGCLHYCL EESNG----RRCACAPGYELADD-------HMRC------------KSTVNFPCGKLG-R WIEKKRKILKRDTD-LE-D-ELEPDPRIVNGTLTKQGDSPWQAILLDS---KK-KLACGG VLIHTSWVLTAAHCVEGT-----KKLTVRLGEYDLRRRDHW--ELDLDIKEILVHPNY-- TRSSSDNDIALLRLAQP-ATLSKTIVPICLPNNGLAQ-ELTQAGQETVVTGWGYQSDRIK DGRRNRTFILTFIRIPLVARNECVEVM-----KNVVSENMLCA--GIIGDTRDACDGDSG GPMVVFF----RGTWFLVGLVSWGEGCGHTNNYGIYTKVGSYLKWIHSYIGEKGVSLKSQ KL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_043316230.1 vitamin K-dependent protein C isoform X1 [Cervus canadensis] ------------------------------------------------------------ ---------------------------MASGG----QPCSFSVAHPR------------- ---DRGAVRGLAQQPCPGAGIRSDLVTRPL----NQTGGCSFRMWQLTSLLLFVTVWG-I SSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------DFEEAREIFQN----------- ---KEDTVAFWSKY-----------------------------------------SDG-- -----DQCEHRPSGSPCELPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLH-------- ----------------------------EVRFS-------------NCSADNGGCAHYCR EEEGR----RHCSCAPGYRLEDD-------HQLC------------EAKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-EQKDQLGPRIVNGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRTFVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVAFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESH V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >KAB0362964.1 hypothetical protein FD754_007120 [Muntiacus muntjak] ------------------------------------------------------------ ---------------------------MAAGG----QPCSFSVAHP-------------- -------------------------------------SGCSFRMWQLTSLLLFVTVWG-I SSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------DFEEAREIFQN----------- ---KEDTVAFWSKY-----------------------------------------SDG-- -----DQCEHRPPGSPCELPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLQ-------- ----------------------------EVRFS-------------NCSADNGGCAHYCR EEAGR----RHCSCAPGYRLEDD-------HQLC------------EAKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-EQKDQLGPRIVNGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRSSVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVAFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >KAB0379809.1 hypothetical protein FD755_007593 [Muntiacus reevesi] ------------------------------------------------------------ ---------------------------MAAGG----QPCSFSVAHP-------------- -------------------------------------SGCSFRMWQLTSLLLFMTVWG-I SSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------DFEEAREIFQN----------- ---KEDTVAFWSKY-----------------------------------------SDG-- -----DQCEHRPPGSPCELPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLQ-------- ----------------------------EVRFS-------------NCSADNGGCAHYCR EEAGR----RHCSCAPGYRLEDD-------HQLC------------EAKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-EQKDQLGPRIVNGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRSSVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVAFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >KAF4026284.1 hypothetical protein G4228_018405 [Cervus hanglu yarkandensis] M-----------------------------FRRK-------------------------- ---------------------------LTALD--YHNPAGFNCKDET------------- ---------------------------------------------EFRNFIVWLEDQK-I RHYKIED----------------------------------------------------- ---------------RDSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------DFEEAREIFQN----------- ---KEDTVAFWSKY-----------------------------------------SDG-- -----DQCEHRPSGSPCELPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLH-------- ----------------------------EVRFS-------------NCSADNGGCAHYCR EEEGR----RHCSCAPGYRLEDD-------HQLC------------EAKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-EQKDQLGPRIVNGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRTFVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVAFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESH V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >NP_001080424.1 protein C, inactivator of coagulation factors Va and VIIIa S homeolog precursor [Xenopus laevis] ------------------------------------------------------------ ---------------------------MN------------------------------- -------------------------------------CLPFYRIWWLLIFHLILVIW--- VSPNAES----------------------------------------------------- ----------------SPVFSSRQ------------------------------------ ------------------------------------------------------------ -------------------------------EANH--------------VLKVRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------AFNFMEELKPGSL---------- -------------------------------------------------ERECI------ ---------------EEKC-------------------DFEEAFEIFET----------- ---KEDTLNFWAKY-----------------------------------------FDG-- -----DQCQSNP---------CVN-AEC--KDGIGRFDCICNEGWEGRLCGY-------- ----------------------------EVVYS-------------NCSLNNGGCSHFCT QPMNST--RRVCSCATGYKLDED-------HHTC------------QPVVEFPCGK---- --------SKIV--------DYDYNARLIGAKQGRKGDTPWQAMLRY----EK-KMKCGG VLIHPSWVLTAAHCVTYT-----GKYSVRLGEYDIRKLEDT--EQQFAVVKIIIHPEY-- RSDTNDNDIALLRLVQP-VVYNKYILPICLPSLDLAENTLMVNGTVVVVSGWGRED---- EKALNFSSVLSYIQIPVVSHNQCAETL-----NDRLSDNMLCA--GRLGHIQDACYGDSG GPMVTKY----GGSWFLLGLVSWGEGCGRINNFGVYTKVNRYLDWITQKIEDEEARRLSE VS---------------------------------------------------------Q AEKQNINKS--------------------------------------------------- ------------------------------------------------------------ -----RKARP-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >OWJ99811.1 PROC [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------------------------MRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRTFVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVAFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESH T-----------------------------HFKRILG--------LQPR--PCDRVSTSP K----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_010726793.1 coagulation factor VII [Meleagris gallopavo] ------------------------------------------------------------ ---------------------------MVSRQ---------------------------- -------------------------------------C-----MALLLCFPLLVPPSL-- ------------------------------------------------------------ ----------------EAVFLKQE------------------------------------ ------------------------------------------------------------ -------------------------------EANS--------------IFQRHRR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFFEEIKLGSL---------- -------------------------------------------------ERECI------ ---------------EEKC-------------------SFEEAREIYRD----------- ---DERTKEFWHIY-----------------------------------------SDP-- -----NQCDSSP---------CQNGGSC--DDQFQDYVCRCPPEYEGKSCET-------- ----------------------------AVDKN------------LKCIYDNGGCEQYCA DQQSE---KRVCFCAEGYTLASD-------GVSC------------IPQVKYPCGK---- --------IPVLA-----KKNATAQGRIVGGVTCPPGECPWQALIIQD---Q--KGKCGG SLLSPEWVVTAAHCLDYT---HPKQLRVRLGEYSTKVDEKT--EQESGVSKVIRHEEY-- TNGQVNHDIALLKLETP-VNLTDFVVPICLPEKRFAVYELS-SIKFSTVSGWGRLL---- DGGAT-STFLMRVDLPRVKTQECEKQA-----NLNITENMFCA--GDLTGKKDSCKGDSG GPHATKY----KNTWFLTGIVSWGKGCAVEGSYGVYTRVSRYIDWLKRYME--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_038049155.1 transmembrane protease serine 9-like isoform X3 [Patiria miniata] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MW--------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------R---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------PRVTRIARYVAVSHD---------------------------PIECGV---- ---------------------PRIRGKIIGGKTTEEGQAPWMALLWNT---KENTHFCGG VLLNQRWVITAAHCFARYKYDIKEHMEVRLGEYDLFKEEGT--ERILQVEQLIVNPEF-- DKDTYDSDIALLKLRQP-VTYTDFIVPICLPS-EMRAMNLLQARTRGFITGWGRTA---- EITTTTTRYLRRVRLLVMDQQTCNNRH-----QDVITNRMFCAMSDDRPTARDSCFGDSG SPFAVRD----NKRWFLIGLVSWGIGCARHRFPGVYTRVHRYTHWITSLIGDDTDTCAGL QE------RVSELTSQ----LSQEEEE-IKQLREQLQEKDRQ---LNESLSCSTQTTNLP STTS--GTTQPSVD----------LRRSTPPLELRIPCRQGSCAHVGGFQVRAVCEDDFC SCESPYYSRESCLPLYGSCVIKHDAPSATARPSYQDEAQ--QTYSCLANDNPKYRVYVLA VHEGNRHTRPPVAGDMEVALDGNAPQEGARG-FVLVLASYEPVNWSIRLIGQLVMDQVIL IAHFPSTVTIAGPYGELRTDIPVLT-SADPCGYGNDSGGGGDTPGMLGVINETVGPVESF TGTYRADKWLLNV----------------------------------------------- ------------------------------------------------------------ ------DEGLHLRDPD-------------------------------------------- --- >XP_031567558.1 CUB and peptidase domain-containing protein 2-like [Actinia tenebrosa] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MDRLSTETLLLLLLATC IRIQAFS--------------------------------------------CNFDKD--- ----------------SCGFTQRA------------------------------------ -------------DDDF-----------NW----RRYQWG-------------------- -------------------------------TPSQ---------GTGPNSDHTTERGYYM -------------------------------------YV--------------------- ------------------------------------------------------------ -------------------------------------EASGKKEGKKAVL---------- -------------------------------------------------ERNVDIS---- --------------GENTCLT----------FYYHMNGRHVGKLNVYVG----------- ---SNKVFSKTASQ-----------------------------------------GDG-- -----WKMAKVS-------LLGANRG-----KQMLKLEGIVGRGFLGDIAID-------- ------------------------------------------------DVSVGLCNEEGT IPPPFP--SATTPIVVLPTTMRP-----------S----------PPIPPSGSCGI---- ----------------------RPKTRIVGGTSSQHGDWPWQAQLKSS---PGSSPFCGG SLIHPQWILTASHCVSGS---KAIKTIVRLGAHRRSVKVGT--EQDFKIIKVITHPSYH- KPISYSNDIALLKLEKP-AKLNRYVNLVCLPD----SVSLPSDGTKCWITGWGRTH---- ---GPSPDYLQQASVPIVSENRCRFAY-----LGXIHDSMMCA--GLDRGGIDSCQGDSG GPMVCEN----GGRFYVQGATSWGNGCGRPGKFGVYAKVKYQLDWIHSEIKKG------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_030830576.1 uncharacterized protein LOC100887833 [Strongylocentrotus purpuratus] ------------------------------------------------------------ ---------------------------MHFLD---------------------------- -------------------------------------------AWFPAGVLIIV------ CCLLSRS----------------------------------------------------- ----------------VAQLIDPE------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------IRNITAS---- -------------AGDDVLLD-------------CVPPDGEALLISWNK----------- ---DNDVVQITDAY-----------------------------------------RDGRI ---FL--------------------------DQKEGMVILNSELWD-------------- ----------------------------RGMYS---------------------CLILTQ DSQIITH-RFWLDIAPPTDSDVD------------------------SNSAFQCGY---- ---------------------CRVRGKVVGGKVSNEGQSPWTALLWNT---NEGKPLCGG VLLNRRWVVTASHCFSLSG-LSIDEFEIRLGEHDIEAISDN--ERTFRAEQIIKHPNF-- NEQTYDSDIALIKLQQP-VTYTDYIIPLCLPS-ELRADELLKAETRGFVTGWGNTE---- EA-GDYSRYLRRVRLTIASMQDCGRSH-----IDIITNNMFCADGGRKADERDACQGDSG GPFVTKD----NNRWYLLGIVSWGVGCARPGYPGVYTRVHRFRQWIMDLVQQDMQTCEES SFELGEELRASVKESNNLRLLNQEQQHLIEYFQEELNRKDEEIFDLHERIETFDCPDGLP TSTSPPESTTPTMTNYPVITETRPVTTRAPIQEDALPCRHNMCWHVSNL---ARCHGGYC VCDSPDYSRVSCLPIVGSCRIYRNNSYALATATFRDDTRIADTFAC--EGNPESNVHIIS VYEGPVHTRPASPGDVHVRVTG-----GDQGPITIVFSSYEPVRWLVSVDEGIMINKFVL TGYYLDLSSVE-VVSLLHTNVTVVTVSRVPFGYGTDGDGVLHTAEFLKYVQNTYGDVGSF SGTYRADRWVLTVPGEAPIVDWMRLPLPIIPMARVESTLSRTGWTPFPFRYDGSFCACHG DQYVKLLGGSENELDYGVRYVGVVLCQTPSHYKIFLANDLEETFLNVGDGSGGGSDHCEF VGGHHENETLAQTSRDWLLMPAVSGYYRSVWGEPVSFGSIGGGYRTWTGKIIVSWYDCGI TIP >XP_006557877.1 serine proteinase stubble isoform X6 [Apis mellifera] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MNWLASLFLILFY---- ------------------------------------------------------------ ----------------IGFYCQAE------------------------------------ ------------------------------------------------------------ -----------------------------------------------------NRK---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------NDRYLKNFDLDTK---------- -------------------------------------------------KETAM------ ---------------ENVI-------------------DSKGQSRFF------------- ------------------------------------------------------------ -----DELGLIP-------QTCTYKGTT--FDCGLSISCVLGGGRPVDLCSG-------- ----------------------------GLIWS--------------CCVDDDDIPDKVP RPTIGL--LQ----------------------------------------NASCGEL--- ---------------------YTRSNRIVGGHSSSFGSHPWQAAIIKSGFLTK-KLSCGG ALLNNRWVVTAAHCVATT---PNGNLKVRLGEWDVRDASEQLLHEEFNVERKEVHPQY-- SPTDFRNDVALVKLSRT-VAFKQHIVPVCLPA-----KNLKISGRTATVAGWGRTR---- HGQSSAPTILQEVDVEVIPNERCQRWFRAAGRRETIHDVFLCA--GYKEGGRDSCQGDSG GPLTMSV----EGRHVLIGLVSWGIGCGREHLPGVYTNIQKFVPWIDKVMS--------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >NP_001097592.1 uncharacterized protein Dmel_CG10663, isoform B [Drosophila melanogaster] ------------------------------------------------------------ ---------------------------MKVVC---------------------------- -----------------------------------------WVLEFLTVVQLLIETQSGY VQEAKRE-----------IWDAMAHHRHRHH--------------------QHYHHG--- ----------------SSHWIDGRRVH--------------------------------- ------------R-----------------LRMPHPQRWS------------GRRRSL-- -------------------------------NQHQPFSRWSQWSPCDEECVRRRERFCKV KRK--CGHTKHVEQSKCSHCHPAPAIKWQPPLILDDSHIRERIQPLPQ------PQPQPP PPPPPSIII-NAAAAASSGPTVDYRY-----TEYKPPPNYASLYPSTHPPIYTPTYPAAH PPTQPPTYPPPTHPPTPPPTPPTNPDEVVRHLPKYPGKDIFSEEDVEDELEPEPDEDLIS S--DEQGDFFVLKHHRHRRRQ---NHRRPSHRKPPKEEDYDDSDFVDFGERKSLRHR--- ------------HLGEDSSVEGDVFQYEDFDLPDTMYADSQESEGEFRNITWMQPAKDGI ALRRRKVYSKWSRW-----------------------------------------TKCS- -----PKCTTRRY------KKCRIMDQC--GREVLREIAYCYT--EGSFCQQ-------- --------------------------WLQTQFQKTPAFE---TRPGSGSPANAMRRMQSE QPEVSMNDLNYIMTGKGYRGPE------------------------YTPLKLSCGI---- --------VRSGTG----RRSMSNMLKIIGGRAARKGEWPWQVAILNR---FK-EAFCGG TLIAPRWVLTAAHCVRKV-------LFVRIGEHNLNYEDGT--EIQLRVMKSYTHPNF-- DKRTVDSDVALLRLPKA-VNATTWIGYSCLPQ----PFQALPKNVDCTIIGWGKRR---- NRDATGTSVLHKATVPIIPMQNCRKVYY----DYTITKNMFCA--GHQKGHIDTCAGDSG GPLLCRDTTKPNHPWTIFGITSFGDGCAQRNKFGIYAKVPNYVDWVWSVVNCDGNCKMH- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] ------------------------------------------------------------ ---------------------------MR------------------------------- ------------------------------------------RIYFFHGICLVLFSFTSS FLSLSLS--------------------------------------------LSLSLS--- ----------------RSLFLSRFL----------------------------------- ------------------------------------------------------------ -------------------------------SLSS--------------SLRRRGR---- -------------------------------------HL--------------------- ------------------------------------------------------------ ---------------------------ISRGSHKYTASSNMSQVDHEGNIIPKRKQSGSS TVMCEHYSAWATWSHCSRRCE---QYR----------------------TRNCVEPR--- ------------YCGNTTIKD----------KRFCKRRNKQCSILSFKVITPLRRAKEVQ QIITNAFYNKWTAW---------------------------------------------- ----------SP---------CSR-------DCKQKRKRQCRSRWK-NVCGES------- ----------------------------YIQQT------------RKCRPVAGTCEKKYT LSVLVA--DEPAETKKGPTSNRHN----KAITNCT----------AELAMPDKCGTR--- ------------------PSGSQRNYRIVGGYEVRRHSWPWQVAILTR---AK-KQYCGG TLISPQWVLTAAHCVRKRG--RKRKVIVRMGEHDLHSRSGN--EITLELEKDFPHPKF-- DFHTISNDIALLKLKRP-VRRSFNVGFACLPT----ETNELHAGTICNIIGWGKVD---- GSHQDGAKILREAEVPVVDQGKCQKAF-----KYKITNNQICA--GFKGGGVDSCGGDSG GPLICANHPNRTTQWANRNAVSVLDA-DFSFSPSLFMH---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >NP_501379.2 Serine protease svh-1 [Caenorhabditis elegans] ------------------------------------------------------------ ---------------------------MYIVI---------------------------- --------------------------------------VTMRTILFFGIFFIFIFQCAKC IELKIFEDLLEVRSQSGLFFPLCSKSFHQKYGEQACASISSTFLSYSTVSLQQYTYSVGC TTSVCFTFLSSFCKTGVKVFCSPSLCASGTLQIGSKCLSISTVPVQGYSEANYYCNPATL ISSLKPTEIESIRDTILPTFADTRLFLTSGLRQGATWKWGNGDTVEQEVTGTGRCLALQA GNLVAIDCDSEAYVFCESGRECIARDKEYSGTANRTSDGKMCLMWNDPTVLFRRERDLEI LNHNFCRFVNDADGKK-----SATPVCYTKPNELSQCYI----PPCPESFNDVVPIESGD SCPIGSISCDNGSKCISEKFQCDYEVDCNDGSDEHNCEDYLQYYE------LIGAYRLAD NIIEVWTFIPHVQGC------------ARKCRESLLMCEAFSYEPKSQTCLLTDTSQTFS SLARKITSLYYRRRFSTKDVEFQVENKVLYATKSAKKGHVCDDNY----SREKLSSICRV LGFGDPIYTVESHQSESSLGP---LQPT---TLHPTNPSFDSPSSVSQM------RRTSP SATLAPRLPAWNLS---CL------------------------------------REPNC TSTVISTCEPIRCSH-CQQAACGD-GSCIRFDQLCNGQIDCQSGEDEDYCRANS----FR LTNGSDTSG-----------------YLEVLFR--SRWEPICADHLNGKISNSICDAMRL GEHGFIL-STNATISSGYNVNCDVDCSIRRSSSCTRHARISCISQNGMSSASQCGLRY-- --------VEVNAR----DAAKSRIARVVGGFETVPGAFPWTAALRNK---ATKAHHCGA SILDKTHLITAAHCFEEDE--RVSSYEVVVGDWDNNQTDGN--EQIFYLQRIHFYPLY-- -KDIFSHDIAILEIPYPGIEFNEYAQPICLPS----KDFVYTPGRQCVVSGWGSMG---- ---LRYAERLQAALIPIINRFDCVNSSQI---YSSMSRSAFCA--GYLEGGIDSCQGDSG GPFACRR---EDGAFVLAGVISWGDGCAQKKQPGIYTMVAPYLSWISAIINGQ------- -----------------------------------------------------------P V----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_008770240.3 vitamin K-dependent protein C isoform X1 [Rattus norvegicus] M-----------------------------LRAI-------------------------- ---------------------------LKAGTPLLSSTCSLRWNINSGNQQR-------- ----------------------------------QRTGVSSSRMWQFRIFLLFASTWG-I SGVSAHP----------------------------------------------------- ----------------DPVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------GAHQ--------------VLRVR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEEVRAGSL---------- -------------------------------------------------ERECM------ ---------------EEIC-------------------DFEEAQEIFQN----------- ---VEDTLAFWIKY-----------------------------------------FDG-- -----DQCSTPPLDHQCDSPCCGH-GTC--IDGLGGFSCSCDKGWEGRFCQQ-------- ----------------------------EMGFQ-------------DCRVKNGGCYHYCL EETRG----RRCACAPGYELADD-------HMHC------------RPTVNFPCGKLW-K RTDKKRKNFKRDID-PE-DEELELGPRIVNGTLTKQGDSPWQAILLDS---KK-KLACGG VLIHTSWVLTAAHCLESS-----KKLTVRLGEYDLRRRDPW--ELDLDIKEVLVHPNY-- TRSNSDNDIALLRLSQP-ATLSKTIVPICLPNSGLAQ-ELSQAGQETVVTGWGYQSDKVK DGRRNRTFILTFIRIPLAARNDCMQVM-----NNVVSENMLCA--GIIGDTRDACDGDSG GPMVVFF----RGTWFLVGLVSWGEGCGHLNNYGVYTKVGSYLKWIHSYIGERDVSLKSP KL---------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_024854240.1 vitamin K-dependent protein C isoform X1 [Bos taurus] ------------------------------------------------------------ ---------------------------MAAGG----QPCSFSAAHPKPDKAEIQFSHPFY KRGDGGAVRGLAQQPCPGAGIRSDLVTRPL----NQTGGCSFRMWQLTSLLLFVTIWG-I SSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGNV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------EFEEAREIFQN----------- ---TEDTMAFWSKY-----------------------------------------SDG-- -----DQCEDRPSGSPCDLPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLH-------- ----------------------------EVRFS-------------NCSAENGGCAHYCM EEEGR----RHCSCAPGYRLEDD-------HQLC------------VSKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-DQKDQLDPRIVDGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHVSWVLTVAHCLDSR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAKP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- ETKRNRTFVLSFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDPRDACEGDSG GPMVTFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAQEAPLESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_015132295.2 vitamin K-dependent protein C isoform X1 [Gallus gallus] ------------------------------------------------------------ ---------------------------MARGGAGVDRECSGRAA---------------- -------------------------------------GDFCCSMWKLITIG-VLLAA--- CSSPVCH----------------------------------------------------- ----------------ASIFYSYK------------------------------------ ------------------------------------------------------------ -------------------------------DANQ--------------VLKIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELKPGSV---------- -------------------------------------------------ERECN------ ---------------EERC-------------------NFEEASEIFET----------- ---KEATLEFWSKY-----------------------------------------VDG-- -----DQCAQKP---------CSN-GAC--KDNIGSYSCICDKGWEGAQCNY-------- ----------------------------EVKYN-------------NCSVDNGGCQHFCK EDPAKQ--CRYCSCASGYQLTND-------HNMC------------TPVVEFPCGR---- --------VKMD---YT-EGKAEFNIRLIGGNSGGRGFSPWQVMLQNL---KG-KFLCGG VLIHPSWVLTAAHCVETG-----ETLKVRLGKYHRLRIENS--EQTIRVDKYVRHENY-- TKLTSDNDIAMLHLAEP-VMYNKYALPICLPTRDLAEHELTTKGRQMLVTGWGSTS---- DEMRNYSALLSYIEIPIVPKNECAQVM-----TNTISDNMLCA--GSLGDRKDSCSGDSG GPMATKY----KDTWFLVGLVSWGEGCGKKEKFGVYTKVSQYLEWIQHHINKKSGSWRG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_020930330.1 vitamin K-dependent protein C isoform X1 [Sus scrofa] ------------------------------------------------------------ ---------------------------MAVRG----QPCSFSAAHS-------------- -------------------------------------SGSNSRMWQLASLLLLLIIWA-V SSTPVPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------MLR-SKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPSSL---------- -------------------------------------------------ERECK------ ---------------EETC-------------------DFEEAREIFQN----------- ---TENTMAFWSKYHGECTPDPWPRCPCSSGSLGHCGYGEGRDPAAPVTPSSPHVADG-- -----DQCAVSPPEHLCDSPCCGR-GTC--IDGLGGFRCDCAQGWEGRFCLH-------- ----------------------------EVRFS-------------NCSTENGGCAHYCL EEEGG----RRCRCAPGYRLGDD-------HLQC------------EPKVKFPCGRLG-N RMEKKRKSLKRDTD-QVDKKEDQIDPRLVNGKQSPWGESPWQVILLDS---KK-KLACGA VLIHVSWVLTAAHCLDDY-----KKLTVRLGEYDLRRREKW--EVDLDIKEFLVHPNY-- TRSTSDNDIALLRLAEP-ATFSQTIVPICLPDSGLSERELTRVGQETVVTGWGYRS---- EAKTNRSFILNFIKVPVAPHNECVQAM-----HNKISENMLCA--GILGDSRDACEGDSG GPMVASF----RGTWFLVGLVSWGEGCGRLHNYGVYTKVSRYLDWIHGHIRMEEAFHKNQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_009441514.3 vitamin K-dependent protein C isoform X1 [Pan troglodytes] MRPHLSRVLPSPPSPLDGILGGQRWASGRPSRAELGPGVLVPLFVYGEGGLSAEGQANIC GYGLTRTPGCHGGRTANLQYLHNPPLQSSSGG----RHCPELRSPPQ------------- ------------------------------------TGASASRMWQLTSLLLFVATWG-I SGTPAPL----------------------------------------------------- ----------------DSVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRHSSL---------- -------------------------------------------------ERECI------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAFWSKH-----------------------------------------VDG-- -----DQCLVLPLEHPCASLCCGH-GTC--IDGIGSFSCDCRSGWEGRFCQRGEGESGAL AGGGA-GLGPGWGRGTSTSCPR-PPLPAEVSFL-------------NCSLDNGGCTHYCL EEVGW----RRCSCAPGYKLGDD-------LLQC------------QPAVKFPCGRPW-K RMEKKRSHLKRDTE----DQEDQVDPRLIDGKMTRRGDSPWQVVLLDS---KK-KLACGA VLIHPSWVLTAAHCMDES-----KKLLVRLGEYDLRRWEKW--ELDLDIKEVFVHPNY-- SKSTTDNDIALLHLAQP-ATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCA--GILGDRQDACEGDSG GPMVASF----HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_038281494.1 vitamin K-dependent protein C isoform X1 [Canis lupus familiaris] ------------------------------------------------------------ ---------------------------MAVGQ----QPSTFFPAHPSSRQNRSWW----- -----GCWK---------------------LRSPPQTGVSNSRMWQLASLSLLLTICG-T CSTAAPP----------------------------------------------------- ----------------GSVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------SAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEEIRAGSL---------- -------------------------------------------------ERECM------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAYWSKY-----------------------------------------VDG-- -----DQCAALPPEHACDSPCCGH-GSC--IDGIGAFHCDCGRGWEGRFCQHGEGGAAGR GGGGQEGGGGGSAVPPALLLLL-PPIHPEVSYI-------------NCSLDNGGCSHYCL EEEGG----RHCSCAPGYRLGDD-------HLQC------------QPAVKFPCGRPG-K QMEKKRKHLKRDTN-QT----DQIDPRLVNGKVTRRGESPWQVVLLDS---KK-KLACGA VLIHTSWVLTAAHCMEDS-----KKLIVRLGEYDLRRWEKG--EMDVDIKEVLIHPNY-- SKSTTDNDIALLHLAQP-AIFSQTIVPICLPDSGLAERELTQVGQETVVTGWGYRS---- ETKRNRTFVLNFINIPVAPHNECIQAM-----YNMISENMLCA--GILGDSRDACEGDSG GPMVTSF----RGTWFLVGLVSWGEGCGRLHNYGIYTKVSRYLDWIHSHIRGEEASLENQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_008256638.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Oryctolagus cuniculus] ------------------------------------------------------------ ---------------------------MAAGR----RTCGFSRAHP-------------- -------------------------------------CASNSRMWQLAGLLLFVATWG-T SSTPAPP----------------------------------------------------- ----------------DSVFTSRE------------------------------------ ------------------------------------------------------------ -------------------------------HAHH--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPSSL---------- -------------------------------------------------ERECV------ ---------------EEVC-------------------DLEEAKEIFQS----------- ---VDDTLAFWYKY-----------------------------------------VDG-- -----DQCAALPSEHPCSSQCCGH-GTC--ADSIGGFSCQCHGGWEGSFCQY-------- ----------------------------EVRFS-------------NCSVDNGGCAHYCL EEEAG----RSCSCAPGYELADD-------HLQC------------EPAVRFPCGRLGWK RIEKKRGNVKRDLE-QV-DEMDEVDPRLIDGKLTRRGDSPWQVILLDS---KK-KLACGA VLIHVSWVLTAAHCMEEP-----KKLFVRLGEYDLRRKERW--ELDLNIQEVLIHPNY-- SRSTTDNDIALLRLAQP-ATLSQTIVPICLPDNGLAERELMQAGQETVVTGWGYHSSREK EAKRNRTFILNFITVPVAPQNECEQVM-----SNIISENMLCA--GILGDRRDACDGDSG GPMVASF----RGTWFLVGLVSWGEGCGDLNNYGVYTKVSRYLDWIHSHIEEKEAAPESP A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_024099270.1 vitamin K-dependent protein C isoform X1 [Pongo abelii] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MWRLTSLLLFVATWG-I SGTPAPL----------------------------------------------------- ----------------DSVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPSSL---------- -------------------------------------------------ERECI------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAFWSKH-----------------------------------------VDG-- -----DQCLVLPLEHPCASPCCGH-GTC--IDGIGSFSCDCRSGWEGRFCQRGEGERGAR AGGGA-GLGQGWGRGTSASCPR-PPLPAEVSFL-------------NCSLDNGGCTHYCL EEVGW----RRCSCAPGYKLGDD-------LLQC------------QPAVKFPCGRPW-K RMEKKRSHLKRDTE----DQEDQVDPRLIDGKMTRRGDSPWQVVLLDS---KK-KLACGA VLIHPSWVLTAAHCMDES-----KKLLVRLGEYDLRRWEKW--ELDLDIEEVFVHPNY-- SKSTTDNDIALLRLAQP-ATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCA--GILGDRQDACEGDSG GPMVASF----HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWVHGHIRAKEAPRKSW A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_034810124.1 vitamin K-dependent protein C isoform X1 [Pan paniscus] ------------------------------------------------------------ ---------------------------MAAGR----RTCSISTTRPC------------- ------------------------------------RAAAGVGTARSSEVLL-------- RQVPAPP----------------------------------------------------- ----------------ECGSSQASCCS--------------------------------- --------------------------------------WPPGE----------------- ------------------------------FPVHQLL-----------LVLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRHSSL---------- -------------------------------------------------ERECI------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAFWSKH-----------------------------------------VDG-- -----DQCLVLPLEHPCASLCCGH-GTC--IDGIGSFSCDCRSGWEGRFCQRGEGESGAL AGGGA-GLGPGWGRGTSTSCPR-PPLPAEVSFL-------------NCSLDNGGCTHYCL EEVGW----RRCSCAPGYKLGDD-------LLQC------------QPAVKFPCGRPW-K RMEKKRSHLKRDTE----DQEDQIDPRLIDGKMTRRGDSPWQVVLLDS---KK-KLACGA VLIHPSWVLTAAHCMDES-----KKLLVRLGEYDLRRWEKW--ELDLDIKEVFVHPNY-- SKSTTDNDIALLHLAQP-ATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCA--GILGDRQDACEGDSG GPMVASF----HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSW A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_023114975.1 vitamin K-dependent protein C isoform X1 [Felis catus] ------------------------------------------------------------ ---------------------------MAAGR----RPCNFSLAHP-------------- -------------------------------------SVSNFRMWQLSSLFLLVTIWG-T SATPAPPD-----SDAFLSWPL-----HQPL--------RPLFLTSLT---WSFHPS--C PQQTPLRALE-----TDSVFSSRE------------------------------------ ------------------------------------------------------------ -------------------------------LSHR--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANTFLEELRAGSL---------- -------------------------------------------------ERECV------ ---------------EEIC-------------------DLEEAQEIFQN----------- ---VDDTLAFWAKY-----------------------------------------IDE-- -----DQCAAPPPDHPCDSPCCGH-GNC--IDGISAFRCDCDPGWEGRFCLY-------- ----------------------------EVSFS-------------NCSLDNGGCAHYCL EEEGG----RRCSCAPGYKLGDD-------HLQC------------EPTVKFPCGRPG-R RMEKKRKTVKRDTS-QA----DQIDPRLVNGKLSGWGESPWQVILLDS---KK-KLACGA VLIHTSWVLTAAHCMEDS-----KKLMVRLGEYDLRRREKW--ELDLDIKEVLMHPNY-- SRSTSDNDIALLRLAQP-AILSQTIVPICLPDSGLAERELTQAGQETVVTGWGHRS---- EAKRNRTFVLNFIKVPVVPQNECINAM-----HNMISENMLCA--GILGDSQDACEGDSG GPMVASF----RGTSFLVGLVSWGEGCGRLHNYGVYTKVSRYLDWIHSHIRAEEASLEGQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_018878397.1 vitamin K-dependent protein C isoform X1 [Gorilla gorilla gorilla] ------------------------------------------------------------ ---------------------------MAAGR----RTCSISTTRP-------------- -------------------------------------CASASRMWRLTSLLLFVATWG-I SGTPAPL----------------------------------------------------- ----------------DSVFSSSE------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRHSSL---------- -------------------------------------------------ERECI------ ---------------EEIC-------------------DFEEAKEIFQN----------- ---VDDTLAFWSKH-----------------------------------------VDG-- -----DQCLVLPLEHPCASLCCGH-GTC--IDGIGSFSCDCRSGWEGRFCQRGEGERGAR AGGGA-GLGPGWGRGTSASCPR-PPLPAEVSFL-------------NCSLDNGGCTHYCL EEVGW----RRCSCAPGYKLGDD-------LLQC------------QPAVKFPCGRPW-K RMEKKRSHLKRDTE----DQEDQVDPRLIDGKMTRRGDSPWQVVLLDS---KK-KLACGA VLIHPSWVLTAAHCMDES-----KKLLVRLGEYDLRRWEKW--ELDLDIKEVFVHPNY-- SKSTTDNDIALLHLAQP-ATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREK EAKRNRTFVLNFIKIPVVPHNECSEVM-----SNMVSENMLCA--GILGDRQDACEGDSG GPMVASF----HGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPRKSW A----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_004078808.1 vitamin K-dependent protein C [Oryzias latipes] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSRLVLCLIVCVTL--- WSASVVS----------------------------------------------------- ----------------LSVFSDAP------------------------------------ ------------------------------------------------------------ -------------------------------QAHM--------------LLRSR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEEMKPPSK---------- -------------------------------------------------ERECI------ ---------------EEKC-------------------DFEEAREIFLT----------- ---REATLEFWTVY-----------------------------------------TDG-- -----NQCQSNL---------CVH-GEC--VDLFQDYACRCNPGYEGKYCEY-------- ----------------------------NVTAT-------------NCSVNNGDCDHDCI EGEDGQ--WRKCSCLNGYNLDKN-------NRKC------------LPQGTTSCGQ---- --------LLISRSEYS-EPLVGLLPWMLGGEVGKKGESPWQVVVLNA---RG-NFHCGG VLINRNWVLTAAHCLENN-----LQFAVRLGDYELLRKEGT--EVMLKVAKAFKHPNY-- NRETVDNDIALLRLVTP-APFNSYIAPICLPGRAMAERVLHLNGTTTVVTGWGKDD---- SG--KYSSALNVIKVPLVSHSVCAQQML----PYTISENVLCA--GILGQRIDACEGDSG GPMVTLY----HGTWFLVGLVSWGEGCGQIDRLGIYTKVSNYNDWIKQVQEEWDRTNNLQ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_005512774.1 vitamin K-dependent protein C [Columba livia] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MWKFVTVG-VLLAA--- CSSRLCS----------------------------------------------------- ----------------TSIFYNNK------------------------------------ ------------------------------------------------------------ -------------------------------DANQ--------------VLKIQKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELKPGSL---------- -------------------------------------------------ERECN------ ---------------EELC-------------------DFEEASEIFET----------- ---REATRDFWSKY-----------------------------------------VDG-- -----DQCEPQP---------CSN-GIC--KDNIGKFSCICNKGWEGLLCNY-------- ----------------------------EVKYT-------------NCSVNNGGCDHFCR DDPANQ--CRYCSCASGYQLMND-------HTMC------------KPVVEFPCGR---- --------VKMD---YI-EGKAEFNIRLIEGKVGRRGISPWQIMLQNS---KG-KFLCGG VLIHPSWVLTAAHCTEAE-----EGLKVRAGKFHRLRTEAE--EQTIWVDKYVIHENY-- TKETSDNDIAMLHLAEP-VMYNKYVLPICLPTRDLAEQELTRNRRQMVVTGWGSTS---- DVNNNYSTFLSYIEIPMVPRNECAQAM-----RFAISDNMLCA--GSLGDKKDSCSGDSG GPMITKY----RDTWFLVGLVSWGEGCGRKEKFGVYTKVSQYLEWIQHHIDEMSASWKG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_017921293.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Capra hircus] ------------------------------------------------------------ ---------------------------MAAGG----QPCSFSVAHPNSGHVTLAL----Y READ-GTVTG-DPDPSSRPGDQHTHTQRRLVHSAPTTGGCGFRMWQLSSLLLFVTVWG-I FSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------EFEEAREIFQN----------- ---TEDTMAFWSKY-----------------------------------------SDG-- -----DQCEQRPSGSPCDLPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLH-------- ----------------------------EVRFT-------------NCSAENGGCAHYCL EEAGR----RHCSCAPGYRLQDD-------HQLC------------ESKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-DQEDQLDPRIVSGQEARWGDSPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENH-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIVHPNY-- TKSTSDNDIALLHLAKP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- ETKKNRTSILNFIKIPVVSYNACVHAM-----ENKVSENMLCA--GILGNSRDACEGDSG GPMVTFF----RGTWFLVGLVSWGEGCGRLYNYGIYTKVSRYLDWIYGHIKA-EAALESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_025065251.1 vitamin K-dependent protein C isoform X1 [Alligator sinensis] ------------------------------------------------------------ ---------------------------MLFTL-----------S---------------- -------------------------------------GVTSCTMWRFMTFSWTLLAA--- CSFCLLE----------------------------------------------------- ----------------ASVFYSRE------------------------------------ ------------------------------------------------------------ -------------------------------DANK--------------VLKIQKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ENSFLEELKAGSL---------- -------------------------------------------------ERECN------ ---------------EESC-------------------DLEEAMEIFES----------- ---REATLSFWTKY-----------------------------------------IDG-- -----DQCEKQP---------CNN-GTC--LDAIGGFNCICNRGWEGLLCQH-------- ----------------------------EVLYT-------------NCSICNGGCDHYCK EDPGNQ--RRYCSCALGYKLMED-------YSQC------------LPDVEFPCGK---- --------VKVN----V-ESKKDIHIRLINGKIGRKGDSPWQVMLSDG---RG-KFKCGG VLIHTAWVLTAAHCVEDD-----RRYKVKLGKYHRLRDEET--EQIILVDKVVIHENY-- TKADSDNDIAMLHLAKP-MVFNKNALPICLPTKELAEQELTRSGKKMVVTGWGSKT---- EKTMNFSNVLNYIEIPLVPRNECVQVM-----RHDISENMLCA--GIIGDQQDACGGDSG GPMITTF----KNTSFLVGLVSWGEGCGKSEKFGVYTKVSQYLQWIQRQMKASENTSNN- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_042099536.1 LOW QUALITY PROTEIN: vitamin K-dependent protein C [Ovis aries] ------------------------------------------------------------ ---------------------------MAAGG----QACSFSVAHP-------------- -------------------------------------SGCGFRMWQLSSLLLFVTVWG-I FSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------EFEEAREIFQN----------- ---TEDTMAFWSKY-----------------------------------------SDG-- -----DQCEQRPSGSPCDLPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLHGEGXGGGG AG-ASPGPGPAGRVEPRRPRGA-LRVCPEVRFT-------------NCSAENGGCAHYCL EEAGR----RHCSCAPGYRLQDD-------HQLC------------ESKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-DQEDQLDPRIVSGQEARWGDSPWQAVLLDS---KK-KLVCGA VLIHVSWVLTVAHCLESH-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIVHPNY-- TKSTSDNDIALLRLAKA-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- ETKKNRTSILNFIKIPVVPYNACVHAM-----ENKVSENMLCA--GILGNSRDACEGDSG GPMVTFF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKA-EAPLESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_006261873.1 PREDICTED: vitamin K-dependent protein C [Alligator mississippiensis] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MWRFMTFSWTLLVA--- CSFCLLE----------------------------------------------------- ----------------ASVFYSRE------------------------------------ ------------------------------------------------------------ -------------------------------DANK--------------VLKIQKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ENSFLEELKAGSL---------- -------------------------------------------------ERECN------ ---------------EESC-------------------DLEEAMEIFES----------- ---REATLSFWTKY-----------------------------------------IDG-- -----DQCEKQP---------CNN-GTC--LDAIGGFNCICNRGWEGLLCQH-------- ----------------------------EVLYT-------------NCSICNGGCDHYCK EDPGNQ--RRYCSCALGYKLMED-------YSRC------------LPDVEFPCGK---- --------VKVN----V-ESKKDIHIRLINGKIGRKGDSPWQVMLSDG---RG-KFKCGG VLIHTAWVLTAAHCVEDD-----RRYKVKLGKYHRLRDEET--EQIILVDKVVIHENY-- TKADSDNDIAMLHLAKP-MVFNKNALPICLPTKELAEQELTRSGKKMVVTGWGSKT---- EKTMNFSNVLNYIEIPLVPRNECVQVM-----RHDISENMLCA--GIIGDQQDACGGDSG GPMITTF----KNTSFLVGLVSWGEGCGKSEKFGVYTKVSQYLQWIQRQMKASENTSNN- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_015811969.1 PREDICTED: vitamin K-dependent protein C-like isoform X1 [Nothobranchius furzeri] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSRLMIFVCVCVAA--- WSALVIS----------------------------------------------------- ----------------QSVFSDAP------------------------------------ ------------------------------------------------------------ -------------------------------QAHM--------------LLRSR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELKPASM---------- -------------------------------------------------ERECV------ ---------------EEDC-------------------DFEEAREIFQT----------- ---REATLEFWTVY-----------------------------------------TDG-- -----NQCQSNM---------CVH-GEC--VDQYQDYACRCRPGYEGKYCQY-------- ----------------------------NITAT-------------NCSMNNGDCDHDCT ESENGL--SRICSCVTGYRLENN-------YRKC------------VPKGSSACGQ---- --------LLISRSEYA-NPQGGLMPWMLGGEVGKKGESPWQVLVLNA---RG-SFHCGG VLIDKNWVLTAAHCLQNN-----HRFSVRLGDYERLITEDT--EVKLEVSKAFKHPNY-- NSQTVDNDIALLRLRTP-APFSKYILPVCLPSRAMAERVLHQNGTVTVVTGWGRDD---- TG--KYSSALNVIKVPLVDHSNCSRQMF----PHQLSNNVLCA--GILGERIDACEGDSG GPMVTLY----QNTWFLVGLVSWGEGCGIKDKPGIYTKVSNYNRWISQVQEEWDRKHQPQ R----------------------------------------------------------A PTV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_020745839.1 vitamin K-dependent protein C isoform X1 [Odocoileus virginianus texanus] ------------------------------------------------------------ ---------------------------MAAGG----QPCSFSVAHS-------------- -------------------------------------SGCSFRMWQLTSLLLFMTVWG-I SSTPAPP----------------------------------------------------- ----------------DSVFSSSQ------------------------------------ ------------------------------------------------------------ -------------------------------RAHQ--------------VLRIRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELRPGSV---------- -------------------------------------------------ERECS------ ---------------EEVC-------------------DFEEAREIFQN----------- ---KEDTVAFWSKY-----------------------------------------SDG-- -----DQCEHRPSGSPCELPCCGR-GKC--IDGLGGFRCDCAEGWEGRFCLHGEGAWTGA VGRGPPGPEPAGRLEPPRPRGALLRVCPEVRFS-------------NCSADNGGCAHYCR EEEGR----RHCSCAPGYRLEDD-------HQLC------------EAKVTFPCGRLG-K RMEKKRKTLKRDTN-QV-EQKDQLGPRIVNGQEAGWGESPWQAVLLDS---KK-KLVCGA VLIHISWVLTVAHCLENR-----KKLIVRLGEYDMRRWESW--EVDLDIKEVIIHPNY-- TKSTSDNDIALLRLAQP-ATLSQTIVPICLPDSGLSERKLTQVGQETVVTGWGYRD---- EVKKNRTSVLNFIKVPVVPYNACVHAM-----ENKISENMLCA--GILGDSRDACDGDSG GPMVALF----RGTWFLVGLVSWGEGCGRLYNYGVYTKVSRYLDWIYGHIKAEEAPLESQ V----------------------------------------------------------P ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_030258505.1 vitamin K-dependent protein C [Sparus aurata] ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MSRLVLCVSVIVTL--- WSVSVLS----------------------------------------------------- ----------------LSVFSDPP------------------------------------ ------------------------------------------------------------ -------------------------------EAHM--------------LLRSR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANSFLEELKPASK---------- -------------------------------------------------ERECI------ ---------------EERC-------------------DFEEAREIFQT----------- ---REATLEFWTVY-----------------------------------------TDG-- -----NQCQSNM---------CVH-GAC--VDQYQSYVCRCNHGYEGRYCDQ-------- ----------------------------LQTAT-------------NCSEDNGGCDHDCT ESEDGL--TRSCSCVSGYKLHDD-------GRKC------------EAIGPSSCGQ---- --------LLIARSSYT-KQVEGPMPWTVGGEVGKKGESPWQVLLLNS---RG-TFHCGG VLIDESWVLTAAHCLEGN-----LRFSVRLGDYERIRIEDT--EVTLRVVETFRHPNYYN RRAVVDNDIALLRLEHP-APFSNYILPVCLPGHEMAERVLHLNGTRTVVTGWGKED---- PNKNRYSSALNVIKIPLVNHDVCSRQM-----SNNVSNNFLCA--GILGQRMDACEGDSG GPMVTLY----RDTWFLLGLVSWGEGCGRVDKLGIYTKVSNYYEWINKVREEWDRSHHPA E----------------------------------------------------------P QHV--------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >tr|A8KC28|A8KC28_DANRE Proc protein OS=Danio rerio OX=7955 GN=proca PE=2 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MRSLFFCALTLVVF--- CSDGALC----------------------------------------------------- ----------------KSVFSSSP------------------------------------ ------------------------------------------------------------ -------------------------------NAHM--------------LLRSR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANTFMEELKPASL---------- -------------------------------------------------ERECR------ ---------------EELC-------------------DFEEAREIFIT----------- ---REATLEFWTAY-----------------------------------------KDG-- -----NQCTTNP---------CVH-GKC--VDLLQDFSCTCDSGFEGKHCDL-------- ----------------------------RRTAT-------------NCSLNNGDCDHDCH ESKDGL--ARTCSCIKGYQLQDN-------SRKC------------APKNDASCGQ---- --------IRIPKSAYANKPKPVLQPWVMGGNVGKRGESPWQALILNH---LG-RFHCGG VLIDENWVLTAAHCLETS-----SKFSVRLGDYQRFRFEGS--EVTLPVKQHISHPQY-- NPITVDNDIALLRLEGP-VKFSTYILPACLPSLELAKRMLHRNGTVTVITGWGKNN---- QSATSYNSTLHYVELPIVDNKECSRHM-----MNNLSDNMLCA--GVLGQVKDACEGDSG GPMMTLF----HDTWFLVGLVSWGEGCGQRDKLGIYTKVASYLDWIDSVRQGWDKV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >tr|B8JLG2|B8JLG2_DANRE Protein C (inactivator of coagulation factors Va and VIIIa), a OS=Danio rerio OX=7955 GN=proca PE=4 SV=1 ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------MRSLFFCALTLVVF--- CSDGALC----------------------------------------------------- ----------------KSVFSSSP------------------------------------ ------------------------------------------------------------ -------------------------------NAHM--------------LLRSR-R---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANTFMEELKPASL---------- -------------------------------------------------ERECR------ ---------------EELC-------------------DFEEAREIFIT----------- ---REATLEFWTAY-----------------------------------------KDG-- -----NQCTTNP---------CVH-GKC--VDLLQDFSCTCDSGFEGKHCDL-------- ----------------------------RRTAT-------------NCSLNNGDCDHDCH ESKDGL--ARTCSCIKGYQLQDN-------SRKC------------TPKNDASCGQ---- --------IRIQKSAY-------LQPCGFAYRVGKRGKSPWQALILNN---LG-RFHCGG VLIDENWVLTAAHCLETS-----SKFSVRLGDYQRFRFEGS--EITLPVKQHISHPQY-- NPITVDNDIALLRLEVP-AKFSTYILPACLPSLELAERMLHRNGTVTVITGWGKDN---- QSATSYNSMLNYVELPIVDNKECSRHM-----MNNLSDNMLCA--GVLGQVKDACEVDSG GPMMTLF----HHTWFLVGLVSWGEGCGQRDKLGIYTKVASYLDWIDSVRQGWDKV---- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --- >XP_040204807.1 vitamin K-dependent protein C [Rana temporaria] ------------------------------------------------------------ ---------------------------MRYRF---------------------------- ----------------------------------------LCTMWWI--LLLSITSF--- TILPAYS----------------------------------------------------- ----------------STIFYNSQ------------------------------------ ------------------------------------------------------------ -------------------------------DANR--------------VLKVRKR---- ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------ANGFFEEMKPGSL---------- -------------------------------------------------ERECY------ ---------------EERC-------------------DLEEANEIFET----------- ---REETLNFWSKY-----------------------------------------FDG-- -----DQCLSNP---------CVN-AVC--KDGIGKFDCTCNGGWEGKFCAY-------- ----------------------------EVTHH-------------SCSLNNGGCTHFCT EIANDT--SRTCSCATGYQLQDD-------GRSC------------KPNGDFPCGR---- --------SKII--------DYDYSARLTGAKKGRKGDSPWQALLVHG----K-KFFCGG VLIHPYWVLTAAHCFKGAP--NDAKFYVRLGEYDRRILEDT--EQQIAVTKLFPHPKF-- DPAEVNNDIALMRLNQA-AVYNKYVLPICLPSYGLAERNLTLEGTETIVTGWGYQD---- QTYRNRTTILSYIQVPIVSQNNCSDVM-----RGRITGNMLCA--GTLGDSQDACSGDSG GPMVIRF----GDTWFLAGLVSWGEGCGRLDNFGVYTKVHYYLDWIDQTMANYETELKKV K----------------------------------------------------------P SHKKKTER---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---
BMGE Cleaned alignment of selected proteins >NP_000303.1 vitamin K-dependent protein C isoform 10 preproprotein [Homo sapiens] -----LLLFVDSVFSSSVLRIRKRANSFLEELRHSSLERECIDFEEAKEIFQNVDDTLAFWSKHLPLEHCASLCCGHIDGIGSFSCDCRSGWEGRFCQNCSLDNGGCTHYCLEEVRRCSCAPGYKLGDDKFPCGRPWLKRDTEDPRLIDGKTRRGDSPWQVVLLDSKLACGAVLIHPSWVLTAAHCMDKKLLVRLGEYDLRRWELDLDIKEVFVHPNYSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNAGQETLVTGWGYNRTFVLNFIKIPVVPHMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLYGVYTKVSRYLDWIHKEAPQK >NP_032960.3 vitamin K-dependent protein C isoform 1 [Mus musculus] MALPGFLLLMDPVFSSSVLRVR-RANSFLEEMRPGSLERECMDFEEAQEIFQNVEDTLAFWIKYPPLDHCDSPCCGHIDGIGSFSCSCDKGWEGKFCQDCRVNNGGCLHYCLEESRRCACAPGYELADDNFPCGKLGLKRDTDDPRIVNGTTKQGDSPWQAILLDSKLACGGVLIHTSWVLTAAHCVEKKLTVRLGEYDLRRRELDLDIKEILVHPNYSSSDNDIALLRLAQPATLSKTIVPICLPNNGLAQ-ELTAGQETVVTGWGYNRTFILTFIRIPLVARVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHYGIYTKVGSYLKWIHKGVSLK >XP_043316230.1 vitamin K-dependent protein C isoform X1 [Cervus canadensis] MASGGLLLFVDSVFSSSVLRIRKRANSFLEELRPGSVERECSDFEEAREIFQNKEDTVAFWSKYRPSGSCELPCCGRIDGLGGFRCDCAEGWEGRFCLNCSADNGGCAHYCREEERHCSCAPGYRLEDDTFPCGRLGLKRDTNGPRIVNGQAGWGESPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTFVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >KAB0362964.1 hypothetical protein FD754_007120 [Muntiacus muntjak] MAAGGLLLFVDSVFSSSVLRIRKRANSFLEELRPGSVERECSDFEEAREIFQNKEDTVAFWSKYRPPGSCELPCCGRIDGLGGFRCDCAEGWEGRFCLNCSADNGGCAHYCREEARHCSCAPGYRLEDDTFPCGRLGLKRDTNGPRIVNGQAGWGESPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRSSVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >KAB0379809.1 hypothetical protein FD755_007593 [Muntiacus reevesi] MAAGGLLLFMDSVFSSSVLRIRKRANSFLEELRPGSVERECSDFEEAREIFQNKEDTVAFWSKYRPPGSCELPCCGRIDGLGGFRCDCAEGWEGRFCLNCSADNGGCAHYCREEARHCSCAPGYRLEDDTFPCGRLGLKRDTNGPRIVNGQAGWGESPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRSSVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >KAF4026284.1 hypothetical protein G4228_018405 [Cervus hanglu yarkandensis] LTALDFIVWLDSVFSSSVLRIRKRANSFLEELRPGSVERECSDFEEAREIFQNKEDTVAFWSKYRPSGSCELPCCGRIDGLGGFRCDCAEGWEGRFCLNCSADNGGCAHYCREEERHCSCAPGYRLEDDTFPCGRLGLKRDTNGPRIVNGQAGWGESPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTFVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >NP_001080424.1 protein C, inactivator of coagulation factors Va and VIIIa S homeolog precursor [Xenopus laevis] MN---FHLILSPVFSSRVLKVRKRAFNFMEELKPGSLERECIDFEEAFEIFETKEDTLNFWAKYNP--------CVNKDGIGRFDCICNEGWEGRLCGNCSLNNGGCSHFCTQPMRVCSCATGYKLDEDEFPCGK--SKIV--NARLIGAKGRKGDTPWQAMLRY-KMKCGGVLIHPSWVLTAAHCVTGKYSVRLGEYDIRKLEQQFAVVKIIIHPEYDTNDNDIALLRLVQPVVYNKYILPICLPSLDLAENTLMNGTVVVVSGWGRNFSSVLSYIQIPVVSHRLSDNMLCAGRLGHIQDACYGDSGGPMVTKYGGSWFLLGLVSWGEGCGRFGVYTKVNRYLDWITEEARRL >OWJ99811.1 PROC [Cervus elaphus hippelaphus] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTFVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVAFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >XP_010726793.1 coagulation factor VII [Meleagris gallopavo] MVSRQFPLLVEAVFLKQIFQRHRRANSFFEEIKLGSLERECISFEEAREIYRDDERTKEFWHIYSP--------CQNDDQFQDYVCRCPPEYEGKSCEKCIYDNGGCEQYCADQQRVCFCAEGYTLASDKYPCGK--IPVLA-QGRIVGGVCPPGECPWQALIIQDKGKCGGSLLSPEWVVTAAHCLDKQLRVRLGEYSTKVDEQESGVSKVIRHEEYGQVNHDIALLKLETPVNLTDFVVPICLPEKRFAVYELSSIKFSTVSGWGRT-STFLMRVDLPRVKTNITENMFCAGDLTGKKDSCKGDSGGPHATKYKNTWFLTGIVSWGKGCAVYGVYTRVSRYIDWLK------ >XP_038049155.1 transmembrane protease serine 9-like isoform X3 [Patiria miniata] -----------------------R-------------------------------------------------------------------------------------------RVTRIARYVAVSHDPIECGV--------RGKIIGGKTEEGQAPWMALLWNTTHFCGGVLLNQRWVITAAHCFAEHMEVRLGEYDLFKEERILQVEQLIVNPEFDTYDSDIALLKLRQPVTYTDFIVPICLPS-EMRAMNLLARTRGFITGWGRTTTRYLRRVRLLVMDQVITNRMFCADDRPTARDSCFGDSGSPFAVRDNKRWFLIGLVSWGIGCARPGVYTRVHRYTHWITDTDTCA >XP_031567558.1 CUB and peptidase domain-containing protein 2-like [Actinia tenebrosa] -----ETLLLSCGFTQRSDHTTEREASGKKEGKKAVLERNVDRHVGKLNVYVGSNKVFSKTASQVS------LLGAN-KQMLKLEGIVGRGFLGDIAI--DVSVGLCNEEGTIPPATTPIVVLPTTMRPSGSCGI--------KTRIVGGTSQHGDWPWQAQLKSSSPFCGGSLIHPQWILTASHCVSIKTIVRLGAHRRSVKEQDFKIIKVITHPSYISYSNDIALLKLEKPAKLNRYVNLVCLPD----SVSLPDGTKCWITGWGRPSPDYLQQASVPIVSEXIHDSMMCAGLDRGGIDSCQGDSGGPMVCENGGRFYVQGATSWGNGCGRFGVYAKVKYQLDWIHG----- >XP_030830576.1 uncharacterized protein LOC100887833 [Strongylocentrotus purpuratus] MHFLDVLIIVVAQLIDP--------------------IRNITDGEALLISWNKDNDVVQITDAY--------------DQKEGMVILNSELWD-------------CLILTQDSQFWLDIAPPTDSDVDAFQCGY--------RGKVVGGKSNEGQSPWTALLWNTKPLCGGVLLNRRWVVTASHCFSDEFEIRLGEHDIEAIERTFRAEQIIKHPNFQTYDSDIALIKLQQPVTYTDYIIPLCLPS-ELRADELLAETRGFVTGWGNDYSRYLRRVRLTIASMIITNNMFCAGRKADERDACQGDSGGPFVTKDNNRWYLLGIVSWGVGCARPGVYTRVHRFRQWIMDMQTCE >XP_006557877.1 serine proteinase stubble isoform X6 [Apis mellifera] -----LFLILIGFYCQA----NRKNDRYLKNFDLDTKKETAMDSKGQSRFF-------------IP------QTCTYFDCGLSISCVLGGGRPVDLCS-CCVDDDDIPDKVPRPTQ-------------NASCGEL-------SNRIVGGHSSFGSHPWQAAIIKSKLSCGGALLNNRWVVTAAHCVAGNLKVRLGEWDVRDAHEEFNVERKEVHPQYTDFRNDVALVKLSRTVAFKQHIVPVCLPA-----KNLKSGRTATVAGWGRSAPTILQEVDVEVIPNTIHDVFLCAGYKEGGRDSCQGDSGGPLTMSVEGRHVLIGLVSWGIGCGRPGVYTNIQKFVPWID------ >NP_001097592.1 uncharacterized protein Dmel_CG10663, isoform B [Drosophila melanogaster] MKVVCVQLLISSHWIDGCVRRRERKDIFSEEDVEDELERKSLDSQESEGEFRNRRKVYSKWSRWRRY-----KKCRIGREVLREIAYCYT--EGSFCQSGSPANAMRRMQSEQPENYIMTGKGYRGPE-KLSCGI--VRSGTGMLKIIGGRARKGEWPWQVAILNREAFCGGTLIAPRWVLTAAHCVR--LFVRIGEHNLNYEEIQLRVMKSYTHPNFRTVDSDVALLRLPKAVNATTWIGYSCLPQ----PFQALKNVDCTIIGWGKTGTSVLHKATVPIIPMTITKNMFCAGHQKGHIDTCAGDSGGPLLCRDNHPWTIFGITSFGDGCAQFGIYAKVPNYVDWVWDGNCKM >CAE1324442.1 Plasminogen,Apolipoprotein(a),Chymotrypsinogen B2,Chymotrypsinogen A,Chymotrypsinogen 2,Chymotrypsinogen B [Sepia pharaonis] MR---ICLVLRSLFLSRSLRRRGRSSNMSQVDHEGNITRNCVNKQCSILSFKVTNAFYNKWTAWSP--------CSR-DCKQKRKRQCRSRWK-NVCGKCRPVAGTCEKKYTLSVEPAETKKGPTSNRHPDKCGTR-------NYRIVGGYVRRHSWPWQVAILTRKQYCGGTLISPQWVLTAAHCVRRKVIVRMGEHDLHSREITLELEKDFPHPKFHTISNDIALLKLKRPVRRSFNVGFACLPT----ETNELAGTICNIIGWGKDGAKILREAEVPVVDQKITNNQICAGFKGGGVDSCGGDSGGPLICANTTQWANRNAVSVLDA-DFPSLFMH--------------- >NP_501379.2 Serine protease svh-1 [Caenorhabditis elegans] MYIVIFFIFIVKVFCSPVLFRRERCEAFSYEPKSQTCSREKLSFDSPSSVSQMLAPRLPAWNLSIRCSHCQQAACGDFDQLCNGQIDCQSGEDEDYCRNGKISNSICDAMRLGEHTNATISSGYNVNCDASQCGLRYVEVNARIARVVGGFTVPGAFPWTAALRNKAHHCGASILDKTHLITAAHCFESSYEVVVGDWDNNQTEQIFYLQRIHFYPLYDIFSHDIAILEIPYPIEFNEYAQPICLPS----KDFVYPGRQCVVSGWGSRYAERLQAALIPIINRSMSRSAFCAGYLEGGIDSCQGDSGGPFACRRDGAFVLAGVISWGDGCAQPGIYTMVAPYLSWISQ----- >XP_008770240.3 vitamin K-dependent protein C isoform X1 [Rattus norvegicus] LKAGTFLLFADPVFSSSVLRVR-RANSFLEEVRAGSLERECMDFEEAQEIFQNVEDTLAFWIKYPPLDHCDSPCCGHIDGLGGFSCSCDKGWEGRFCQDCRVKNGGCYHYCLEETRRCACAPGYELADDNFPCGKLWFKRDIDGPRIVNGTTKQGDSPWQAILLDSKLACGGVLIHTSWVLTAAHCLEKKLTVRLGEYDLRRRELDLDIKEVLVHPNYSNSDNDIALLRLSQPATLSKTIVPICLPNSGLAQ-ELSAGQETVVTGWGYNRTFILTFIRIPLAARVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHYGVYTKVGSYLKWIHRDVSLK >XP_024854240.1 vitamin K-dependent protein C isoform X1 [Bos taurus] MAAGGLLLFVDSVFSSSVLRIRKRANSFLEELRPGNVERECSEFEEAREIFQNTEDTMAFWSKYRPSGSCDLPCCGRIDGLGGFRCDCAEGWEGRFCLNCSAENGGCAHYCMEEERHCSCAPGYRLEDDTFPCGRLGLKRDTNDPRIVDGQAGWGESPWQAVLLDSKLVCGAVLIHVSWVLTVAHCLDKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAKPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTFVLSFIKVPVVPYKISENMLCAGILGDPRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYQEAPLE >XP_015132295.2 vitamin K-dependent protein C isoform X1 [Gallus gallus] MARGGIG-VLASIFYSYVLKIRKRANSFLEELKPGSVERECNNFEEASEIFETKEATLEFWSKYKP--------CSNKDNIGSYSCICDKGWEGAQCNNCSVDNGGCQHFCKEDPRYCSCASGYQLTNDEFPCGR--VKMD--NIRLIGGNGGRGFSPWQVMLQNLKFLCGGVLIHPSWVLTAAHCVEETLKVRLGKYHRLRIEQTIRVDKYVRHENYLTSDNDIAMLHLAEPVMYNKYALPICLPTRDLAEHELTKGRQMLVTGWGSNYSALLSYIEIPIVPKTISDNMLCAGSLGDRKDSCSGDSGGPMATKYKDTWFLVGLVSWGEGCGKFGVYTKVSQYLEWIQKSGSWR >XP_020930330.1 vitamin K-dependent protein C isoform X1 [Sus scrofa] MAVRGLLLLLDSVFSSSMLR-SKRANSFLEELRPSSLERECKDFEEAREIFQNTENTMAFWSKYSPPEHCDSPCCGRIDGLGGFRCDCAQGWEGRFCLNCSTENGGCAHYCLEEERRCRCAPGYRLGDDKFPCGRLGLKRDTDDPRLVNGKSPWGESPWQVILLDSKLACGAVLIHVSWVLTAAHCLDKKLTVRLGEYDLRRREVDLDIKEFLVHPNYSTSDNDIALLRLAEPATFSQTIVPICLPDSGLSERELTVGQETVVTGWGYNRSFILNFIKVPVAPHKISENMLCAGILGDSRDACEGDSGGPMVASFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIHEEAFHK >XP_009441514.3 vitamin K-dependent protein C isoform X1 [Pan troglodytes] SSSGGLLLFVDSVFSSSVLRIRKRANSFLEELRHSSLERECIDFEEAKEIFQNVDDTLAFWSKHLPLEHCASLCCGHIDGIGSFSCDCRSGWEGRFCQNCSLDNGGCTHYCLEEVRRCSCAPGYKLGDDKFPCGRPWLKRDTEDPRLIDGKTRRGDSPWQVVLLDSKLACGAVLIHPSWVLTAAHCMDKKLLVRLGEYDLRRWELDLDIKEVFVHPNYSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNAGQETLVTGWGYNRTFVLNFIKIPVVPHMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLYGVYTKVSRYLDWIHKEAPQK >XP_038281494.1 vitamin K-dependent protein C isoform X1 [Canis lupus familiaris] MAVGQLSLLLGSVFSSSVLRIRKRANSFLEEIRAGSLERECMDFEEAKEIFQNVDDTLAYWSKYLPPEHCDSPCCGHIDGIGAFHCDCGRGWEGRFCQNCSLDNGGCSHYCLEEERHCSCAPGYRLGDDKFPCGRPGLKRDTNDPRLVNGKTRRGESPWQVVLLDSKLACGAVLIHTSWVLTAAHCMEKKLIVRLGEYDLRRWEMDVDIKEVLIHPNYSTTDNDIALLHLAQPAIFSQTIVPICLPDSGLAERELTVGQETVVTGWGYNRTFVLNFINIPVAPHMISENMLCAGILGDSRDACEGDSGGPMVTSFRGTWFLVGLVSWGEGCGRYGIYTKVSRYLDWIHEEASLE >XP_008256638.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Oryctolagus cuniculus] MAAGRLLLFVDSVFTSRVLRIRKRANSFLEELRPSSLERECVDLEEAKEIFQSVDDTLAFWYKYLPSEHCSSQCCGHADSIGGFSCQCHGGWEGSFCQNCSVDNGGCAHYCLEEERSCSCAPGYELADDRFPCGRLGVKRDLEDPRLIDGKTRRGDSPWQVILLDSKLACGAVLIHVSWVLTAAHCMEKKLFVRLGEYDLRRKELDLNIQEVLIHPNYSTTDNDIALLRLAQPATLSQTIVPICLPDNGLAERELMAGQETVVTGWGYNRTFILNFITVPVAPQIISENMLCAGILGDRRDACDGDSGGPMVASFRGTWFLVGLVSWGEGCGDYGVYTKVSRYLDWIHKEAAPE >XP_024099270.1 vitamin K-dependent protein C isoform X1 [Pongo abelii] -----LLLFVDSVFSSSVLRIRKRANSFLEELRPSSLERECIDFEEAKEIFQNVDDTLAFWSKHLPLEHCASPCCGHIDGIGSFSCDCRSGWEGRFCQNCSLDNGGCTHYCLEEVRRCSCAPGYKLGDDKFPCGRPWLKRDTEDPRLIDGKTRRGDSPWQVVLLDSKLACGAVLIHPSWVLTAAHCMDKKLLVRLGEYDLRRWELDLDIEEVFVHPNYSTTDNDIALLRLAQPATLSQTIVPICLPDSGLAERELNAGQETLVTGWGYNRTFVLNFIKIPVVPHMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLYGVYTKVSRYLDWVHKEAPRK >XP_034810124.1 vitamin K-dependent protein C isoform X1 [Pan paniscus] MAAGRVLL--ECGSSQAVLRIRKRANSFLEELRHSSLERECIDFEEAKEIFQNVDDTLAFWSKHLPLEHCASLCCGHIDGIGSFSCDCRSGWEGRFCQNCSLDNGGCTHYCLEEVRRCSCAPGYKLGDDKFPCGRPWLKRDTEDPRLIDGKTRRGDSPWQVVLLDSKLACGAVLIHPSWVLTAAHCMDKKLLVRLGEYDLRRWELDLDIKEVFVHPNYSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNAGQETLVTGWGYNRTFVLNFIKIPVVPHMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLYGVYTKVSRYLDWIHKEAPQK >XP_023114975.1 vitamin K-dependent protein C isoform X1 [Felis catus] MAAGRLFLLVDSVFSSRVLRIRKRANTFLEELRAGSLERECVDLEEAQEIFQNVDDTLAFWAKYPPPDHCDSPCCGHIDGISAFRCDCDPGWEGRFCLNCSLDNGGCAHYCLEEERRCSCAPGYKLGDDKFPCGRPGVKRDTSDPRLVNGKSGWGESPWQVILLDSKLACGAVLIHTSWVLTAAHCMEKKLMVRLGEYDLRRRELDLDIKEVLMHPNYSTSDNDIALLRLAQPAILSQTIVPICLPDSGLAERELTAGQETVVTGWGHNRTFVLNFIKVPVVPQMISENMLCAGILGDSQDACEGDSGGPMVASFRGTSFLVGLVSWGEGCGRYGVYTKVSRYLDWIHEEASLE >XP_018878397.1 vitamin K-dependent protein C isoform X1 [Gorilla gorilla gorilla] MAAGRLLLFVDSVFSSSVLRIRKRANSFLEELRHSSLERECIDFEEAKEIFQNVDDTLAFWSKHLPLEHCASLCCGHIDGIGSFSCDCRSGWEGRFCQNCSLDNGGCTHYCLEEVRRCSCAPGYKLGDDKFPCGRPWLKRDTEDPRLIDGKTRRGDSPWQVVLLDSKLACGAVLIHPSWVLTAAHCMDKKLLVRLGEYDLRRWELDLDIKEVFVHPNYSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNAGQETLVTGWGYNRTFVLNFIKIPVVPHMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLYGVYTKVSRYLDWIHKEAPRK >XP_004078808.1 vitamin K-dependent protein C [Oryzias latipes] -----CLIVCLSVFSDALLRSR-RANSFLEEMKPPSKERECIDFEEAREIFLTREATLEFWTVYNL--------CVHVDLFQDYACRCNPGYEGKYCENCSVNNGDCDHDCIEGERKCSCLNGYNLDKNTTSCGQ--LLISRSLPWMLGGEGKKGESPWQVVVLNANFHCGGVLINRNWVLTAAHCLELQFAVRLGDYELLRKEVMLKVAKAFKHPNYETVDNDIALLRLVTPAPFNSYIAPICLPGRAMAERVLHNGTTTVVTGWGKKYSSALNVIKVPLVSHTISENVLCAGILGQRIDACEGDSGGPMVTLYHGTWFLVGLVSWGEGCGQLGIYTKVSNYNDWIKWDRTNN >XP_005512774.1 vitamin K-dependent protein C [Columba livia] -----VG-VLTSIFYNNVLKIQKRANSFLEELKPGSLERECNDFEEASEIFETREATRDFWSKYQP--------CSNKDNIGKFSCICNKGWEGLLCNNCSVNNGGCDHFCRDDPRYCSCASGYQLMNDEFPCGR--VKMD--NIRLIEGKGRRGISPWQIMLQNSKFLCGGVLIHPSWVLTAAHCTEEGLKVRAGKFHRLRTEQTIWVDKYVIHENYETSDNDIAMLHLAEPVMYNKYVLPICLPTRDLAEQELTNRRQMVVTGWGSNYSTFLSYIEIPMVPRAISDNMLCAGSLGDKKDSCSGDSGGPMITKYRDTWFLVGLVSWGEGCGRFGVYTKVSQYLEWIQMSASWK >XP_017921293.1 PREDICTED: vitamin K-dependent protein C isoform X1 [Capra hircus] MAAGGLLLFVDSVFSSSVLRIRKRANSFLEELRPGSVERECSEFEEAREIFQNTEDTMAFWSKYRPSGSCDLPCCGRIDGLGGFRCDCAEGWEGRFCLNCSAENGGCAHYCLEEARHCSCAPGYRLQDDTFPCGRLGLKRDTNDPRIVSGQARWGDSPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIVHPNYSTSDNDIALLHLAKPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTSILNFIKIPVVSYKVSENMLCAGILGNSRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRYGIYTKVSRYLDWIY-EAALE >XP_025065251.1 vitamin K-dependent protein C isoform X1 [Alligator sinensis] MLFTLFSWTLASVFYSRVLKIQKRENSFLEELKAGSLERECNDLEEAMEIFESREATLSFWTKYQP--------CNNLDAIGGFNCICNRGWEGLLCQNCSICNGGCDHYCKEDPRYCSCALGYKLMEDEFPCGK--VKVN--HIRLINGKGRKGDSPWQVMLSDGKFKCGGVLIHTAWVLTAAHCVERRYKVKLGKYHRLRDEQIILVDKVVIHENYADSDNDIAMLHLAKPMVFNKNALPICLPTKELAEQELTSGKKMVVTGWGSNFSNVLNYIEIPLVPRDISENMLCAGIIGDQQDACGGDSGGPMITTFKNTSFLVGLVSWGEGCGKFGVYTKVSQYLQWIQSENTSN >XP_042099536.1 LOW QUALITY PROTEIN: vitamin K-dependent protein C [Ovis aries] MAAGGLLLFVDSVFSSSVLRIRKRANSFLEELRPGSVERECSEFEEAREIFQNTEDTMAFWSKYRPSGSCDLPCCGRIDGLGGFRCDCAEGWEGRFCLNCSAENGGCAHYCLEEARHCSCAPGYRLQDDTFPCGRLGLKRDTNDPRIVSGQARWGDSPWQAVLLDSKLVCGAVLIHVSWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIVHPNYSTSDNDIALLRLAKAATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTSILNFIKIPVVPYKVSENMLCAGILGNSRDACEGDSGGPMVTFFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIY-EAPLE >XP_006261873.1 PREDICTED: vitamin K-dependent protein C [Alligator mississippiensis] -----FSWTLASVFYSRVLKIQKRENSFLEELKAGSLERECNDLEEAMEIFESREATLSFWTKYQP--------CNNLDAIGGFNCICNRGWEGLLCQNCSICNGGCDHYCKEDPRYCSCALGYKLMEDEFPCGK--VKVN--HIRLINGKGRKGDSPWQVMLSDGKFKCGGVLIHTAWVLTAAHCVERRYKVKLGKYHRLRDEQIILVDKVVIHENYADSDNDIAMLHLAKPMVFNKNALPICLPTKELAEQELTSGKKMVVTGWGSNFSNVLNYIEIPLVPRDISENMLCAGIIGDQQDACGGDSGGPMITTFKNTSFLVGLVSWGEGCGKFGVYTKVSQYLQWIQSENTSN >XP_015811969.1 PREDICTED: vitamin K-dependent protein C-like isoform X1 [Nothobranchius furzeri] -----FVCVCQSVFSDALLRSR-RANSFLEELKPASMERECVDFEEAREIFQTREATLEFWTVYNM--------CVHVDQYQDYACRCRPGYEGKYCQNCSMNNGDCDHDCTESERICSCVTGYRLENNSSACGQ--LLISRSMPWMLGGEGKKGESPWQVLVLNASFHCGGVLIDKNWVLTAAHCLQHRFSVRLGDYERLITEVKLEVSKAFKHPNYQTVDNDIALLRLRTPAPFSKYILPVCLPSRAMAERVLHNGTVTVVTGWGRKYSSALNVIKVPLVDHQLSNNVLCAGILGERIDACEGDSGGPMVTLYQNTWFLVGLVSWGEGCGIPGIYTKVSNYNRWISWDRKHQ >XP_020745839.1 vitamin K-dependent protein C isoform X1 [Odocoileus virginianus texanus] MAAGGLLLFMDSVFSSSVLRIRKRANSFLEELRPGSVERECSDFEEAREIFQNKEDTVAFWSKYRPSGSCELPCCGRIDGLGGFRCDCAEGWEGRFCLNCSADNGGCAHYCREEERHCSCAPGYRLEDDTFPCGRLGLKRDTNGPRIVNGQAGWGESPWQAVLLDSKLVCGAVLIHISWVLTVAHCLEKKLIVRLGEYDMRRWEVDLDIKEVIIHPNYSTSDNDIALLRLAQPATLSQTIVPICLPDSGLSERKLTVGQETVVTGWGYNRTSVLNFIKVPVVPYKISENMLCAGILGDSRDACDGDSGGPMVALFRGTWFLVGLVSWGEGCGRYGVYTKVSRYLDWIYEEAPLE >XP_030258505.1 vitamin K-dependent protein C [Sparus aurata] -----CVSVILSVFSDPLLRSR-RANSFLEELKPASKERECIDFEEAREIFQTREATLEFWTVYNM--------CVHVDQYQSYVCRCNHGYEGRYCDNCSEDNGGCDHDCTESERSCSCVSGYKLHDDPSSCGQ--LLIARSMPWTVGGEGKKGESPWQVLLLNSTFHCGGVLIDESWVLTAAHCLELRFSVRLGDYERIRIEVTLRVVETFRHPNYAVVDNDIALLRLEHPAPFSNYILPVCLPGHEMAERVLHNGTRTVVTGWGKRYSSALNVIKIPLVNHNVSNNFLCAGILGQRMDACEGDSGGPMVTLYRDTWFLLGLVSWGEGCGRLGIYTKVSNYYEWINWDRSHH >tr|A8KC28|A8KC28_DANRE Proc protein OS=Danio rerio OX=7955 GN=proca PE=2 SV=1 -----CALTLKSVFSSSLLRSR-RANTFMEELKPASLERECRDFEEAREIFITREATLEFWTAYNP--------CVHVDLLQDFSCTCDSGFEGKHCDNCSLNNGDCDHDCHESKRTCSCIKGYQLQDNDASCGQ--IRIPKSQPWVMGGNGKRGESPWQALILNHRFHCGGVLIDENWVLTAAHCLESKFSVRLGDYQRFRFEVTLPVKQHISHPQYITVDNDIALLRLEGPVKFSTYILPACLPSLELAKRMLHNGTVTVITGWGKSYNSTLHYVELPIVDNNLSDNMLCAGVLGQVKDACEGDSGGPMMTLFHDTWFLVGLVSWGEGCGQLGIYTKVASYLDWIDWDKV-- >tr|B8JLG2|B8JLG2_DANRE Protein C (inactivator of coagulation factors Va and VIIIa), a OS=Danio rerio OX=7955 GN=proca PE=4 SV=1 -----CALTLKSVFSSSLLRSR-RANTFMEELKPASLERECRDFEEAREIFITREATLEFWTAYNP--------CVHVDLLQDFSCTCDSGFEGKHCDNCSLNNGDCDHDCHESKRTCSCIKGYQLQDNDASCGQ--IRIQKSQPCGFAYRGKRGKSPWQALILNNRFHCGGVLIDENWVLTAAHCLESKFSVRLGDYQRFRFEITLPVKQHISHPQYITVDNDIALLRLEVPAKFSTYILPACLPSLELAERMLHNGTVTVITGWGKSYNSMLNYVELPIVDNNLSDNMLCAGVLGQVKDACEVDSGGPMMTLFHHTWFLVGLVSWGEGCGQLGIYTKVASYLDWIDWDKV-- >XP_040204807.1 vitamin K-dependent protein C [Rana temporaria] MRYRFLLLSISTIFYNSVLKVRKRANGFFEEMKPGSLERECYDLEEANEIFETREETLNFWSKYNP--------CVNKDGIGKFDCTCNGGWEGKFCASCSLNNGGCTHFCTEIARTCSCATGYQLQDDDFPCGR--SKII--SARLTGAKGRKGDSPWQALLVHGKFFCGGVLIHPYWVLTAAHCFKAKFYVRLGEYDRRILEQQIAVTKLFPHPKFAEVNNDIALMRLNQAAVYNKYVLPICLPSYGLAERNLTEGTETIVTGWGYNRTTILSYIQVPIVSQRITGNMLCAGTLGDSQDACSGDSGGPMVIRFGDTWFLAGLVSWGEGCGRFGVYTKVHYYLDWIDYETELK
PhyML tree of selected proteins (XP_030830576_1_uncharacterized_protein_LOC100887833__Strongylocentrotus_purpuratus_:0.53060392,XP_038049155_1_transmembrane_protease_serine_9_like_isoform_X3__Patiria_miniata_:0.42702581,(XP_006557877_1_serine_proteinase_stubble_isoform_X6__Apis_mellifera_:1.8350405,((NP_501379_2_Serine_protease_svh_1__Caenorhabditis_elegans_:2.1113443,(XP_031567558_1_CUB_and_peptidase_domain_containing_protein_2_like__Actinia_tenebrosa_:1.77708898,(CAE1324442_1_Plasminogen_Apolipoprotein_a__Chymotrypsinogen_B2_Chymotrypsinogen_A_Chymotrypsinogen_2_Chymotrypsinogen_B__Sepia_pharaonis_:1.28065692,NP_001097592_1_uncharacterized_protein_Dmel_CG10663__isoform_B__Drosophila_melanogaster_:1.07437279):0.51436447):0.32281555):0.24080079,(XP_010726793_1_coagulation_factor_VII__Meleagris_gallopavo_:1.03239646,(((tr_B8JLG2_B8JLG2_DANRE_Protein_C__inactivator_of_coagulation_factors_Va_and_VIIIa___a_OS_Danio_rerio_OX_7955_GN_proca_PE_4_SV_1:0.04216578,tr_A8KC28_A8KC28_DANRE_Proc_protein_OS_Danio_rerio_OX_7955_GN_proca_PE_2_SV_1:0.01510998):0.24767492,(XP_030258505_1_vitamin_K_dependent_protein_C__Sparus_aurata_:0.13044807,(XP_004078808_1_vitamin_K_dependent_protein_C__Oryzias_latipes_:0.16114761,XP_015811969_1_PREDICTED__vitamin_K_dependent_protein_C_like_isoform_X1__Nothobranchius_furzeri_:0.10834037):0.07539618):0.1833607):0.36108361,((((XP_025065251_1_vitamin_K_dependent_protein_C_isoform_X1__Alligator_sinensis_:0.00000001,XP_006261873_1_PREDICTED__vitamin_K_dependent_protein_C__Alligator_mississippiensis_:0.00000001):0.31819982,(XP_005512774_1_vitamin_K_dependent_protein_C__Columba_livia_:0.0728627,XP_015132295_2_vitamin_K_dependent_protein_C_isoform_X1__Gallus_gallus_:0.13514374):0.09971019):0.25225338,(NP_001080424_1_protein_C__inactivator_of_coagulation_factors_Va_and_VIIIa_S_homeolog_precursor__Xenopus_laevis_:0.27726979,XP_040204807_1_vitamin_K_dependent_protein_C__Rana_temporaria_:0.34109938):0.13131822):0.0868323,((NP_032960_3_vitamin_K_dependent_protein_C_isoform_1__Mus_musculus_:0.02887747,XP_008770240_3_vitamin_K_dependent_protein_C_isoform_X1__Rattus_norvegicus_:0.06865507):0.17632769,((XP_038281494_1_vitamin_K_dependent_protein_C_isoform_X1__Canis_lupus_familiaris_:0.08799604,(XP_008256638_1_PREDICTED__vitamin_K_dependent_protein_C_isoform_X1__Oryctolagus_cuniculus_:0.14229192,(XP_024099270_1_vitamin_K_dependent_protein_C_isoform_X1__Pongo_abelii_:0.00603203,(XP_018878397_1_vitamin_K_dependent_protein_C_isoform_X1__Gorilla_gorilla_gorilla_:0.00000001,(XP_034810124_1_vitamin_K_dependent_protein_C_isoform_X1__Pan_paniscus_:0.02197649,(XP_009441514_3_vitamin_K_dependent_protein_C_isoform_X1__Pan_troglodytes_:0.00000001,NP_000303_1_vitamin_K_dependent_protein_C_isoform_10_preproprotein__Homo_sapiens_:0.00000001):0.01214839):0.00296863):0.00936999):0.07182952):0.04394322):0.01263196,(XP_023114975_1_vitamin_K_dependent_protein_C_isoform_X1__Felis_catus_:0.06746629,(XP_020930330_1_vitamin_K_dependent_protein_C_isoform_X1__Sus_scrofa_:0.08274192,((XP_024854240_1_vitamin_K_dependent_protein_C_isoform_X1__Bos_taurus_:0.01930787,(XP_042099536_1_LOW_QUALITY_PROTEIN__vitamin_K_dependent_protein_C__Ovis_aries_:0.00321693,XP_017921293_1_PREDICTED__vitamin_K_dependent_protein_C_isoform_X1__Capra_hircus_:0.01509575):0.03504281):0.01318393,(XP_043316230_1_vitamin_K_dependent_protein_C_isoform_X1__Cervus_canadensis_:0.00304571,((XP_020745839_1_vitamin_K_dependent_protein_C_isoform_X1__Odocoileus_virginianus_texanus_:0.00304487,(KAB0379809_1_hypothetical_protein_FD755_007593__Muntiacus_reevesi_:0.00000001,KAB0362964_1_hypothetical_protein_FD754_007120__Muntiacus_muntjak_:0.00308819):0.00923185):0.00442493,(OWJ99811_1_PROC__Cervus_elaphus_hippelaphus_:0.00000001,KAF4026284_1_hypothetical_protein_G4228_018405__Cervus_hanglu_yarkandensis_:0.00084308):0.02742386):0.00201167):0.02360834):0.09901676):0.06879962):0.02339486):0.04965961):0.37896344):0.0827924):0.24997884):0.36411644):0.06930464):0.95941886);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)