PB0034

DATABASE

Click here to access PB0034 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0034	P36980	Complement factor H-related protein 2	CFHR2	CFHL2, FHR2, HFL3	Homo_sapiens	Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

Domains	Gene Ontology
PF00084 (4_Sushi)	GO:0005515 (enables) protein binding GO:0042802 (enables) identical protein binding GO:0032091 (involved in) negative regulation of protein binding GO:0051838 (involved in) cytolysis by host of symbiont cells GO:0005576 (located in) extracellular region GO:0032991 (part of) protein-containing complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P36980|FHR2_HUMAN Complement factor H-related protein 2 OS=Homo sapiens OX=9606 GN=CFHR2 PE=1 SV=1 MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFV SPSKSFWTRITCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRL QNNENNISCVERGWSTPPKCRSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQN LYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFV CKSGYHPTKSHSFRAMCQNGKLVYPSCEEK >tr|E2FHP6|E2FHP6_DANRE Complement factor H-like 2 protein OS=Danio rerio OX=7955 GN=cfhl2 PE=2 SV=1 MNVPAKLLGFVVWLLCLNCGQCEDCLGTDINYENVEPVLEWSYPDGKTVRVTCQTGYTGM YRLRCEDGKWSENIARPCAKKRCSHPGEAANADFKLLDGTEYVFGTTVVYTCKKGYKMKS RINHRTCRSQGWDNAIPVCEAVTCELTSNYEVKRVVPEGKTIFRAGERLTITCTEKTWFR SKETIKTFACQDDGTWDSNPGCEGMCARPDIPNAKIIGDLRQSYSTNSTIRYKCNPGFEP EETVQITCDHQAQWTGLQQCTAKQEVCPDVHVKNGFSQPLNKTVIFYACNKGYKPFNGEW WSSVTCVKGSWSDVPLCIRKEECGAFPSVQNGKLKLKDQETAEIDCDPGFISSTPSIKCN NGTWETPTCNEGVRCGIPPYVDNSVIISKPEVVYIHGSSVTYTCRSPFVMIGKSTVFCSN GKWEETPTCEARCLRPLENYMSLANDKDTYQDKEILNYQCLKPYDKIPEGGWICENGKWT GDFVCTSDICPPPPYIENGSHFSRNPDDKMPTEVYYECQAYYVLSERKQYYRCENGRWRT PPKCLKPCQITQDILEAHNMRPDQQTGYIKHGDYVDYYCQHRLIVRTGHYKKATCSDGKL EIESCE
Selected proteins from model organisms >NP_005657.1 complement factor H-related protein 2 isoform 1 precursor [Homo sapiens] MWLLVSVILISRISSVGGEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRI TCAEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC RSTISAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVIS QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFRAMCQNGKLVYPSCEEK >XP_024206509.1 complement factor H-related protein 2 isoform X1 [Pan troglodytes] MWLMVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPPKSFWTRI TCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC RSTDASCVNPPTVQNAHILSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGYWTEPPQCKDSTGECGP PPPIDNGDITSFPLSVYAPASSVEYQCQNLYELEGNKRITCRNGQWSEPPKCLHPCVISREIMEKCNIAL RWTAKQKLYSRTGETVEFVCKHGYRLSPSSHTLRTTCWDGKLEYPTCVKR >XP_019677270.1 complement factor H-related protein 2-like isoform X1 [Felis catus] MLLLISVILTLWVSCAHGQGRTCGFPEIKHGNIYDEDRYKHNFPVALGKYFYYSCDHSFASPSQSLWTKITCTEEGWSPT PKCIRQCFFPWVENGHSASSGQTHQEGDTAKIVCDTDYRLLNNQSNITCTESGWSIPPKCSSTDPKRKCGPPPPIDNGDI TSFPLSTYAPGSLVEYQCQSFYELQGNKNIICSHGQWSEPPKCLDACVISEEAMDKHNIQLRWRHEKKFYSKTGDIIEFV CKSGYHKKTPHHTFRITCQEGKLEYPTCVKNNG >NP_001037692.1 complement factor H-related protein 1 precursor [Rattus norvegicus] MGFCRLLFLVNVLLTSWFSSAKGEGIHCDFPKIRHGIVYDEKKYEPFSPVPGGKILYYSCEYNFASPSSSFWNPIICTEA GWSPVPKCLRICFFPSVENGHSTSSGQTHKEGDIVQIVCNQGYSLQNNQSTITCGEEGWSIPPKCISPNSAGKCGPPPSI DNGDITSLSLPEYAPLSSVEYQCQNYFLLKGNKIITCRNGKWSDPPTCLHACVIPEDILEKHNIVLRWRENGRIYSQSGE NIEFMCKPGYRKLRGSPPFRSKCIDGHINYPTCL >KAB0344555.1 hypothetical protein FD754_021481 [Muntiacus muntjak] MSNKLLLLNVILTLWVCCAHGQGRMCDFPEIKHGSIYNENKYKKIFPADVGKYFYYTCDHSFVTPSQSLWTRINCTEGGW SPAPKCLRQCFFPWVENGQSTSSGQTHREGDIVHIVCDTGYSLPNGQSNITCGERGWSSPPECRRVYSQGRCGPPPPIDN GDTTSFPLPQYPPGSAVEYQCQAYYVLQGDRYIVCRNGEWSEPPKCLDPCVISEEMMKQHNIQLKWKNDKKIYTRTDDTI EFTCKRGYRPRTPNHTFRTTCQKGKLAYPHCE >XP_020771892.1 complement factor H-related protein 2-like [Odocoileus virginianus texanus] MNVPLRMSNKLLLRNVILTLWVCCAHGQGRTCDFPEIKHGSIYNENKYKKIFPADVGKYFYYTCDHSFVTPSQSLWTRIN CTERGWSPAPKCLRQCFFPWVENGQSTSSGQTHQEGDVVHIVCDTGYSLPNGQSNIACGEGGWSSPPECRRVYPQGRCGP PPPVDNGDTTSFPLSQYPPGSAVEYRCQAYYVLQGERHIVCRNGEWSEPPKCLDPCVISEEMMKQHNIQLKWRDDKKIYT RTDDTIEFMCKHGYRPRTPNHTFRTTCQKGILVYPHCE >KAB0377273.1 hypothetical protein FD755_011717 [Muntiacus reevesi] MSNKLLLLNVILTLWLCCAHGQGRMCDFPEIKHGSIYNENKYKKIFPADVGKYFYYTCDHSFVTPSQSLWTRINCTEGGW SPAPKCLRQCFFPWVENGQSTSSGQTHREGDIIHIVCDTGYSLPNGQSNITCGERGWSSPPECRRVYSQGRCGPPPPIDN GDTTSFPLPQYPPGSAVEYQCQAYYVLQGDRYIVCRNGEWSEPPKCLDPCVISEEMMKQHNIQLKWKNDKKIYTRTDDTI EFTCKRGYSPRTPNHTFRTTCQKGKLAYPHCE >XP_043341406.1 complement factor H-related protein 2-like [Cervus canadensis] MNVPLRMSNKLLLLNVILTLWVCCAHGQGRMCDFPEIKHGSIYNENKYKKIFPADVGKYFYYTCDHSFVTPSQSLWTRIN CTEGGWSPAPKCLRQCFFPWVENGQSTSSGQTHQEGDTVHIVCDAGYSLPNGQSNITCGERGWSSPPECRRVYPQGRCGP PPPVDNGDTTSFPLTQYPPGSAVEYQCQAYYVLQGDRYIVCRNGEWSEPPKCLDPCVISEEMMKQHNIQLKWRDDKKIYT RTDDTIEFTCKRGYRPRTPNHTFRTTCQKGKLVYPHCE >XP_020937508.1 complement factor H isoform X7 [Sus scrofa] MHVPLGIPNMLSLINVLHVLLSLWVSCAHGQGRTCDLPEIKHGRIYDENRYKQVFPVNVGQYFYYTCDHSFVSPSQLLWS RITCTDAGWSPTPKCLRQCFFPWVENGLSASSGQTHREGDTVQIACDPGYRLANNQSSITCAEGGWSSPPKCSPAYSQGK CGPPPPIDNGDTTSFPLPVYPPGTVVEYQCQSYYELEGSSSIKCENGQWSEPPKCLDACVVSEEMMRKHNIELKWTLGKK LYSRTDDTIEFRCRQGFYRRTPLHTFRVTCQQGKLAYPTCG >XP_004013976.1 complement factor H-related protein 2 [Ovis aries] MSNMLLLLNVILTLWVCCAHGQGRMCDFPEIKHGSIYNENRYKKFFPTDVGKYFYYTCEHSFVTPSQSLWTRINCTEEGW SPTPKCLRQCFFPWVENGQSTSSGQTHREGDIVHIVCNAGYSLPNGQSSIACGESGWSSPPVCRRVYPQGRCGPPPPIDN GDTVSLPLPQYPPESAVEYKCQAYYVLQGDKHIVCRNGEWSEPPKCLGACVISEEMMQQHNIQLKWRQDKKLYTRTDDSI EFTCKYGYRPTTPNHTFRTTCHEGKVVYPHCE >XP_005691103.1 PREDICTED: complement factor H-related protein 2 [Capra hircus] MNVPLRMSNMLLLLNVILTLWVCCAHGQGRTCDFPEIKHGSIYNENRYKKSFPADVGKYFYYTCEHSFVTPSQSLWTRIN CTEEGWSPTPKCLRQCFFPWVENGQSTSSGQTHREGDVVHIVCNAGYSPPNGQSSIACGESGWSSPPECRRVYPQGRCGP PPPIDNGDTVSLPLPQYPPESAVEYKCQAYYVLQGDKHIVCRNGEWSEPPKCLGACVISEEMMQQHNIQLKWRQDRKLYT RTDDNIEFTCKYGYRPTTPNHTFRTTCHEGKVVYPHCE >XP_002694314.1 complement factor H-related protein 2 [Bos taurus] MNLPLRMSNMLLLLNVILTLWVCCAHGRGKTCDFPEIKHGSIYNENRYKKIFPADVGKYFYYTCEHSFVTPSQSLWTRIN CTEEGWSPTPKCLRQCFFPWVENGQSTSSGQTHREGDIVHIVCDTGYSLPNGQSNITCGERGWSSPPECRHVYPRGRCGP PPPIDNGDTVSFPLSQYPPGSAVEYQCQAYYVLQGNRHIVCRNGEWSEPPKCLDACVISEEMMKQHNIQLKWRDDKKLYT RTDDTIEFTCKRGYRPTTPIRTFRTTCHEGKVVYPHCE >XP_008266942.1 PREDICTED: complement factor H isoform X10 [Oryctolagus cuniculus] MRLPAKVLWFVICTVCVAQDCKEPPPKKNIEILSGSWNEQTYPEGTQAVYKCRPGYRTLGTIVMTCRNGEWVAVNPARVC RKKPCGHPGDTPFGSFHLAVGNEFEFGAKVVYTCNEGYRMLGDIDYRECAVDGWTNDIPLCEVVKCLPVKEPENGKIISE LEPDQEYFFGQVIQFECNSGFKLDGDKQIHCSENGIWSGIKPQCVEISCNSPVITNGHSLSQKKIYKKNERFQYKCNPGF EYTERGDAVCTSSGWSPEPSCKEVTCNAPYIPNGSYLPKRIQHRTGDEIKYECKTGFYPATRGNTARCTGSGWVPGPRCS LKPCDFPQINHGRLYYEDRYRPYFPVAVGNYYSYHCNPNFVTPSNSYWDYIHCTKEGWSPKVPCLRKCTFSYVENGYRPS SERPYLQNESVKVDCYPGYSLPNEQTEITCTENGWSPLPKCIRVNSTGKCGPPPPIENGDITSLSLPVYTSGSSVEYQCQ SLYRLEGDKKIMCRNGKWGKPPKCLHACVISEEIMEKYNITLKWKERQKLYSQTGDTVEFICKYGYHPTTSQSFRKTCQD GKLEYPSCAKKAGRYYHY >XP_030839713.1 complement receptor type 2 [Strongylocentrotus purpuratus] MELEPYIIFVISTVVGMAWGQTCTINECSEESLPKPMGSGLSGYTPGGTGCYDDGTLVTYICTGSLLGPPTSQCSAGIWF PPVGPTCEAASGCFRPQLPPNGNVTEYKDEYALYDRITFYCDDGYSIIGPQEVVCDSGGIWDPSNIPTCEASCTAPSIQN GGPNGTYVNGEVITYTCDVNYTLIGVSSATCRDELWDPTNVPECLEQCLPPIVANSNFDTQQDLFDHGSSVIIDCDPGYS TGSSTSTTVNCNDGSLSMESPRCYENCSPLDTFLNGQVTGDTSPFYHTETVSFSCDTGFTLDGATSITCSDGAWDAPQPM CMDQCPVIVPEAYSAFYGSAPPFQHGDMVTFTCYSGYEIYNGSITSTCQNGQWSSDPPFCTEQTTTTQAASTMMDSITTK LPSTSMTTLQDTVTPSTSQSSDTSPEAASTDVVLQTDKDLNTSRVYRQVTFNQHDDYTRYNVAVYPNVNRSGIYRRPSNV FRDHYRSCHRNEDLNTRRVYRQFTFNQHEDCTRYNVTVYFPNFPNVNRSGIYRRPSNVESHHD >XP_038073060.1 low-density lipoprotein receptor-related protein 2-like [Patiria miniata] MDGTGGSRKRWCLQHFLLSVLLTTFRTAHAGDFALIADLNNGTIYAGSMGRSLVDLAPLPLSGIVRPVTVDFDPQERMIY WSDLRSQPSPKISRANLDGSNQMTIAENLRLPDGLALDVEARILYWTDGVLGHVGRASMNGTGNKEIIVENLDQPRTIVT DHSHGHIYWTDWGSSPRIERADLDGGNRTSVVDSDLHWPNGVTIDADYLYWCDAFLNKIERSDLSGQNRELVIDLNPYGD LHPYDLDVYRGDVYWTDWKVNTLIRVSLNGRGEGNFGPSTFQQPGGIHIEEEPDHCDSSPCDNGAPCEDVIGGFLCQCPP GLQGTTCSDATSCVLPPDPSDVLMVVSGQQAVYLPGDSVQYACPDGYQLSGSTTRICLSDLTWSGQQPTCSLTVVGCAPP TPDPSDVLMVVSGGQAVYHPGDSVQYACPDGYQLSGSATRICLSDFTWAGEAPVCQDELEPTPDVSGCTPPTPGPSDVLM VVSDQRAVYLPGDSVQYACPDGYQLSGSATRICRSDFTWAGEAPQCMEDDPATVSGCTPPTPDPSDVLMVVSDQRTVYQL GDSVQYACPDGYQLSGSATRRCRSDFTWTGQAPQCKKEDPISGKSTGAIPVAIIAGGSGGAVLFLVAVAIICVVAITVKR RRRRRFGGRVPISDIADRTCKEVFPKEYSTYVHYEKHIAEPLYSETLF >XP_031560273.1 CUB and sushi domain-containing protein 3-like isoform X2 [Actinia tenebrosa] MLFTKEKVLVLMVFVFALFKPKTDASTCSTLSIKLPLKARHVGSSTWFGAGDVLKFHCESSGATKPYYKLKGVIKIECQK DGTWSSKIPICAASACPAVGPSVPNAQLLTTIIPGGTNNFGNRINYRCNLGFKLGSSSSNKICQKNGYWEGNVTCVGIVC PLPSINYGNVTYSSLGYGSVANYTCDKGYAVNGQPIRICDKSGHWSGNTPLCLRLCPQLSAPTNGYIKNLVDYLASREVG ATIRFVCNPNYRMRGNKFRTCEANGRWSGQQPKCVINTCGSPGPFSNGVMTSSLPNYIIGTVVNFSCHSGYKLIGDVSRR TCMHDGHWTGIQNPTCKILFCEEPGNIFYGSHDKHSDKYSYGSSVSYSCDSRYYLWGNATLTCQAVSSGLTYWSGSIPSC LTLPRFEEKCVRLKGKFKVEHGRPICLFPATTATHLKGERKADRELDTLTIVTASAGSTLGALVILLSVMVFVRRFHRSR RFRNHSIRSRFYSDDDHVTLIATCREDVHFALPSYDEAMSQVQRDPPPFETVVQSNGVGPTNNNSPVLPITGVASNPEGR DDRDNPSAHAQNENSADQHINIVNNPMNENSSEGTSLLSQVANQGETPSEQPQESFVMNTLSSEESLVESDPTSSREGLN LSVSEDEQSINESQPLIISNT >EDL39525.1 mCG9172 [Mus musculus] MGFCRLLLLAIVLLTSWFSTAKGEVSLCDFPKIRHGILYDEKKNEPFSSVLSGKILYYSCEYNFASPSNSFWTRITCTES GWSPTPKCLRLCFFPFVENGNSTSSGQTHVEGDIVQVVCNQGYSLQNNQSTITCAEEGWSITPKCISTNPTGKCGPPPPI DNGDITSLSLPVYASLSSVEYQCQKYYLLKGNKTITCRNGKWSEPPTCIYPTGEMWAPSTY >XP_038526744.1 complement factor H-related protein 5 [Canis lupus familiaris] MLLINAILILWISTVGGQGPFHCNFPKINHGIIYGREDSEAFSPVPVGTIYYYSCEYNFASPSRSFWTRIMCTEEGWSPT PKCLRLCFFPSVENGYSASSGQTHLEGDIVQIICDVGYSLPYNDDTITCLENGWSPPPKCNSTNVECLLPVLEANVGVYP RRVRYKTGEVLQFSCEQGLTGVGPASVQCYYFGWSPSFPTCKGQVQSCGPPPQLLNGKIKEARKEEYGHREMVEYDCDPY FLMTGPKTIQCMDGQWTDLPTCTGQAKTCDYIPHFENGYAQFSIPPFRHGVSMKLNCRKTYTMIGNNVITCIDGMWTELP TCVATDQLKSCRRPVFSARILMYPHRNKFNHSTRVIYRCLGKPGYKQTVCINGQWHPELHCKRDMEQLCPPPPQIPNAQN MLTTVNYQDKEKVAILCKENYLLHGPRDIVCKNGQWQSLPRCIESTQYCGPPPPVSNGDITSFPLSVYPPGSRVQYRCQS FYELRGSTDIICINGQWSEPPKCIDACIIYEGNMNKNNIQLRGKNIRNLYVKTGDFVEFDCKQPYKAKTSMQSFRALCQE GKIEYPMCG >XP_019343938.1 PREDICTED: complement factor H-related protein 1 [Alligator mississippiensis] MCGGPPIVANANVVGKRNQRYQTGERVQYECQEHFEIMPSSYIVCANGEWSQPPVCKAMTCGPAPVIANGGIMGFGKQRY FPGERVRYRCHDGLSLIGLQIITCKDGIWSQPPECKEASGKCGTPPPIDNGDITSFLLKEYESDSQVEYKCQHFYVMEGN NILTCVLGQWTDPPICLEPCTVSEEEMEKNNIVLSGEKKLYSLAGEAIEFECKTGYKRDPTSPALRAQCFEGKLQYPRCK IGS >XP_014373981.1 complement factor H-like isoform X2 [Alligator sinensis] MSSIAGAGFIFWILRMTLLRYMFIQLLWAYSSQAEVQPCDYPQVENIELSGYYQSNRERAFPAKTGSSMYYRCAQGYVTA TEENWVLIRCTRDGWDPAPKCIKTCSFPRLENGRINYSSWRKFKEGETTSYSCYQGYSPENEQDRITCTKNGLSPTPRCI LDPTCHADHLENGRFLGNYWRTSYKINERMTYSCNSENDRENQQRTVTCTKNGWWPTPRCIPDKTCTRPNLENILLKTNK TVFSLGHDLIYECVVGYQTIHKITIDYTVCGRNGWIPEPQCLAIECEMLTLPNGEMSPRKGKYHNGDVVTFSCAKGYTRV GPDSAQCYYFGWSPAPPLCKDELRFCEQPPAIHNGSIISECQQQYPHGSTMEYRCNHRFKMIGSSKIECIDGAWSPLPSC TEAKKKCPPPPQVPGALKVTEMRNYESGEEIPFQCLENFEASAEVDKIMCKDGKWQSPPRCIEKYVCRSPRPLENGKLRQ EHQNLGMEQSGPITYPDGAVLEYTCNTGFVLNGRSEITCNMGTWTAAPTCDEMPCGKVPSVLHSLPRRGEKNHYEAGITV RYECKRGFKIHGEQNIICQAGNWTKPPTCEEFFGKCGPPPAIENGDITSFPLKQYEQDSRVEYKCQHLYVMEGSQFATCN VGEWTEPPTCIEPCTVSEEDLEKNNIKLKWTPVGKLYSASGDFIEFVCKEGYVKDPTSPPFRVQCLKGKLSYPQCRL >XP_025008854.1 complement factor H isoform X2 [Gallus gallus] MPFLGYAALLLCWMYCTAERACEQSPPRRVKEIPTETWDNPPYPHGTLVTYKCRPGYIKIGRIVVKCADGVWKQQGNTEC RSKPCGHPGDIEFGSFQLTAGNEFVFGARVEYRCNDGYRMLSQKNYRECLAEGWSNDIPHCEVAKCLPVKAPENGRIVLS GAFELNREYSFGEVMEFECNEHYRLVGSKAIHCSSNGKWDSDVPQCQDIICNVPSIPNGVVRSSQKTYRESEQLHYVCNK GYTYGERADAQCTESGWSPTPYCTEVVCFPPTFRNGNFRPQKDRYTEGATITIDCDLGYRYSTLTAKNVAKCTSSGWVPA PGCVEKPCDYPAVENIRLSGNWQQNYFPMRIGQTIYYRCREGYLTPSEEYWVHIVCSQGGWKPEPQCLKRCDVGPLENGY IQNNWKRYFKEGERTKYFCNKNYRTENEDGEITCSKNGWSPTPRCIRKETCQWVDLTNGYFMERRATFDIGETVSYSCYN DFVTPEKQKMGMIQCQKNGWSPPPKCIPIECKLPVLSHGQAHPSKNTYYNGDVVKFICVKNYIRVGPASSQCYYFGWFPS PPTCKVDPRDCGPPPEITNGNVIGGFLERYQHGNRMEYECDTPFTLVGSKEIECLDGQWSSLPSCIENKMPCGSPSSVLN VVLLQQDRAQFSHGDEVTYRCSQGSENATRMRTKCLNGEWKPSPLCNDPFHQCVTPEDIVIERTGSHRKAKETGLYLTYK CKPADRQFKQATCVSGKWTPEIQCTGESTCPLPPQLPNANKIPIGRNYKNGSKIAFSCLEGFHLIGANEIMCINGKWQSP PYCVEKPCSPPQPVEHADDVRLVNQSLKMEKEGKTVYLAGAVVKFTCHSGFELDGPSEISCSMGNWSSYPTCSEASCGSI PNVPNSAIEGRNKEAYEPGETIRYQCDEGFEAVGVPEIICRKGNWSTPPFCEDVSCEAPPEIHNAYITSPQQQRYLPGAR VQYECDSHFQITAVNYVTCSNGQWLQTPTCKDTRCGPPPEISGGKVQGFKKSRYLPGETAKYECWKGFRMTGASTVSCQN GTWTELPTCKGKSEKCGPPPDIENGDILSFPMPEYSQGETLKYKCPNLYILEGSQQITCINGQWTNPPVCLVACTAAEED MNNNNIELKWREESKLYSRPGDFIEFDCKIGNVEDPASSPFRVQCINGTFKYPRCNPGRDCRVLESEMDKNNIQLQWRMP HTYRSKERISFKCKWLYEPVSRPEKFKPRCLDGVIEYPQCAYRWK >XP_010713972.1 complement factor H [Meleagris gallopavo] MKIGRIVVKCADGEWKQQGNTECRSKPCGHPGDTEFGSFQLTAGKEFVFGARVEYRCNDGYRMLSQKNYRECLAEGWSND IPHCEVAKCLPVKAPENGRIVVSGAFELNREYSFGQVIEFECNEHYRLVGSKAIHCSSNGRWDSDVPQCQDIICSVPSIP NGNVRSSQKTYKESEQLHYVCNKGYTYGERANVQCTESGWYPTPYCTEVVCFPPTFRNGNFRPQKDRYIEGATITIDCDS GYRFSTLTAKNVAKCTSNGWVPAPGCIEKPCDYPAVDNIMLSRNWQQNYFPMRIGQTIYYGCRQGYLTPTEQYWIQIVCS PGGWKPEPQCLKICDVRYLENGVMQSNWRRYYKEGERAKYFCNTNYRTDSEDGEITCTKNGWSPTPRCIRKETCQYVDLT NGYFLKNKATFDIGETVTYRCYNDFVTPERQEIGEIQCQVAGWSPPPKCIQFCKTPQTRVLTDCTTRKIYLPGDTLEYAC HEQYHTADNMPTGTTMCGVNGEWKPAPQCVAIECELPELSNRVVHPAKSRYYNGDVVKFSCIDNHVRVGPASAQCYYFGW FPSPPTCKVNPRGCGPPPEVTNGNVTGSFLEWYPNGNRMEYECDTQFKLVGSKEIECLDGEWSSPPSCIEDKMPCGSPSS IPNIVLQQQYRVQFSHGEEVTYRCKQGSGNASRMRTKCLNGEWKPSPLCNAPSHQCVPPEDIVVVRTNSLRKAKETELYL TYKCKQADRQLKQATCVSGKWSPEIQCTGESTCPPPPQLPNANKIPVGRNYKNGSKIAFSCLEGFHLIGANEITCINGKW QSPPYCVEKPCSPPQLIENADDFRLVNQNLKMEKEGKTVYLAGAVVKFICHSGFELEGPSEINCSMGNWSSSPTCSEMSC GSIPNVHNSATEGRNKEVYEPGETIRYQCDEGFEAVGLPEIICRKGNWSTPPFCEDVTCEAPPEIHSANIISTQQQRYLP GARVQYECDSNFQITGVNYVTCTNGQWSQTPTCKDMRCGPPPEIAGGKVHGVKKSKYLPGETAKYACWEGFRMTGASTVG CQNGTWTELPTCRGKSGKCGPPPEIEYGDILSFPKAEYSQGETLKYKCPNLYILEGSQQIRCINGQWTNPPVCLVACTAA EEDMNNNNIELKWREEKKLYSKPGDFIEFDCKIGNVKDPASSPFRVQCINGTLKYPRCNPGRDCKVLHSEMDKNNIKLQL EERYIYRSNERISFTCKWFQKAVSRPEKFNPKCLDGVIEYPQCTRVIG >PKK27813.1 coagulation factor XIII B chain [Columba livia] MKMRFKSCFFFLVTMYSGKLFAEDKPCDLPHIENGKIAQYYYSFKSYYFPMHKEKKLSYSCMIGYTTESGTQDGRITCTA KGWSPVPRCYKKCSKPLLENGFFYGTETYFKIEEKLQYKCNPGYHTPSGGTEDTVQCQPEGWSSQPSCAKKIESCQVPNL HHGSYFTDRQELRLNETLLYRCDEGYHTAGGNTTEEAVCLTHGWSLPPNCTKITCSSLSAIAHGGFYPVKKIYEEGDVVH FFCEENYSVTVFDLIQCYYFGWYPDPPVCEGVKNKCPPPPLPPHAHIITVKRTYHNGDKARIQCQSTVETEIQCVEGKWS SPPICIGAMDKREPEAPPPLEAQAAVRTSKTYHDEDTKMQQNCTSPPVIKNGVLLGPLLTSYKNGSSVEYSCQRYHFLEG PSTVYCEQGNWTEQPMCLEPCTLNVTDLDSNNIELKWRQEELIFLHGDLVEFECKQGYNFLQTTVLSPGRTQCNHGRLKY PKCILQAPTEKCDSPPSIANGALTLPPLTQYDSGSSVQYSCSDYHFLQGSETIYCSEGQWTSPPVCIEPCTLSKDEMEKN NVLLQGFYGNQVYFYHGDYVGFYCKQNHFGAESGTTLFQVQCKRGQLTYPRCIESEADGPVARPVAFEELWMKHKNTCLE MALLSCTVVFLLWLGCTAHEGTACEDPPVIDFGEIISGNKSRYMERDRVQYMCNAGFTLSGSEWVTCHEKMWVPGPPQCL APCIITKQQLQVKNLLLSDGQRHSFLIQSGRWQKFMCVTGFKLTAFPIRQCFNGHIKLPSCVIERPCGSIPKVANAQIEG RNKASYEPGETVSYQCDEGFLIVGTPEIICREGNWTAPPFCEDVTCGTAPEIPNAHITSTQQERYLPGARVQYECESNFQ MMDINYVTCTNGQWSRAPTCRDVTCEPPPEIAGGKIEGVKKSRYLPGESARYQCWRGFQMTGSASVTCRTGNWTELPKCK GEGGKCGPPPVIKNGDLLSSPMQEYSPGTTLEYKCPSLYLLEGSQYITCTDGQWTSPPVCLVACTASEEDMSSNNIELKW VRGRKLYSTSGDFVEFKCRRGYVKDPASSPFRVQCVEGTLEYPRCKPGRNCILDKSTMEGNHIQLQSSKLSSMSTYRSGD YIDFECKWWHQKVSRAESFRAECLDGVIQYPTCEYVFG >XP_040215769.1 coagulation factor XIII B chain-like [Rana temporaria] MKCFRKREKNMGKFCFILLAFAESFFYPAEGNMCDLPKMENAVIAPYFYTFTKFYFPMKEGKTLSVACSAGHTFQSGMQE EKITCTPEGWDPPAVCFKKCIQPTLINGIVHNGKDSYKTSETAQYSCFEGYTTKGGHKSEQIQCSSGSWDPTPGCLQLSD RCVAPPLDNGIYTTTKRNFRIKEIIQYQCNTGYYTASGSTADWAECLRHGWSSTPHCAKSSCGKLANVENGGFHPVKASY ADRDVVQFSCKENYLTKGSELIQCYSYGWDPEPPTCEERRKRCPPPPRPAHSILLNNSALHHTGDIVHYECDDNYKLIGT EKIHCENGQWTTPPTCIELKEKIECGKPPPTDNGTAVIEREIYSSGDSIFYKCVDGYEIQGSNKIICRKGKWTEPPKCKA NNEDCGSPPKISQGELTGAALARYTTGSSVEYRCHSYHLMEGTKTVYCTRGTWLQLPKCLEPCTVSVLDMKERNVDLQWH FEINSKFLHGDMVEFKCMDGFDTSTHSELKGLCQNGHILYPSCSIKGTLKSCGTSPVVTHSTVNSSQKVYLSGSVVIYQC SEHYYLNGKSMVRCSNGLWEDPPICIEPCILSREEMSKNNIHLKWTLYSDYILHREFVDFLCMAGYENYETTLAFALRSE CRYGQLKYPKCVSRNR >XP_041446564.1 coagulation factor XIII B chain [Xenopus laevis] MSVYKFCILLLCHWFCFAQENGCDLPVVENGKIAQYYYVFKKFYFPMKEGKKLSLSCAAGYSTQSGKQEEQITCKGVAWE PASLCFKKCIKPSLNHGNVHNPKDSYKFLERAHYSCLEGYVTVSGNQTEEVQCLANGWSSQPECHQISDGCEAPRLYNGH YTTTKRAFHVKEILQYQCDEGYGTPSGRTADETECLLRGWSSVPQCTKQSCKELQPVQNGGFYPVKAMYVDRDVVQFFCT EGYILRDSELIQCYSFGWYPEPPSCEEKSNKCPPPPRPAHIILLTDPAVHRNGDSARYECDYNYMLIGSEEIYCENGRWT APPSCVELKEKLKCAPPPYVENGEVMLQAEVYYSGDRVNFQCAEGYEIQGSSEIICKMGKWPEPPKCKAKSDFCQIPPPL TNGELIDLPSLSYKNSESVEYRCKSYHLMEGPKTVNCTHGKWTELPTCLEPCTVSVDLMRQRNLELKWSFEMDTYFLHGD MIEFVCKDDLDMSEHPEGLKGMCQRGNIRYPTCSRKDKLNACGPPPLVKNGRVLAPQENYESGSSAVYMCSEHHFLNGSN TVQCSDGDWDHPPTCIEPCVLSKEEMERNQIRLRWSFDNKDYFYHGEYIEFLCIDGHENTSPTIMFSLRAQCSDGQIKYP KCVLRAR >XP_015826626.1 PREDICTED: complement factor H-like isoform X3 [Nothobranchius furzeri] MWRVSLFGVQGCEKTMFTIAKSVVLLLWTQTFIFVKCQDCTLEQFLKSPNYDVNFETSGLAATYGPGKQVRVPCKIGFMG FYKLICSEGRWVHRGSICEIKSCGHPGDAAFGDFRLEKKDDFVYGSQVVYECQRGYHMVSRSNIRRCQAEGWDGVVPVCE AIRCPSIPLPDGMQVVGDLDEATFGNVVQFSCRNNSHVLEGSRVLHCNENGEWQGTAPKCKEIKCNAPVIENGRVEGNRQ EYKKDEWLTFSCNDGFKKVYDFRPKCQKLGQHGNAEWAPTPACKKITCELSQPPPLGTAYSTQNSVFLPRQTVRVTCGER YSIINTKTTEAVVTCQVDGEWDTWRVCKEVTCSGHLPEDNLSWTTNRNTWGRNRLGDTVSYSCAWSYERTDGAQHATCTR DGWTPKPLCRATSAPCPHPDFENAVITYGGKDSYNRNDKVRYRCQTGNGETFTATCREGAWTESTGCAASCPPPDFQDAD IIHGAKYNYISDDQVQYRCKSGNRETFTAICKEGTWAEAKKCADQSGCGRPPSLTDGETVRFTKQQYENGDTVEYTCYNM YVLKGGRFKTCNNGVWTGEMRCMKPCIVNAEMMERHNIEFSRNDRDKYYAPHEDHLTFVCKHGTRLLHQEPMRKQCINGQ MDLPTCG >XP_030289713.1 complement factor H-related protein 1-like isoform X4 [Sparus aurata] MRLFHLLWLFILWLKMEKSLQSDEVLCDKPDIQDADIIHNEKESYSDKEQVQFECKNGLEKRFTVTCEQGNWIEIQSCAA ECQITGVPENVIITPNVQNNQLRSGQQLRFACRHPGHFLRGNAAVECLAHGQWSAPFPTCGDPLGCNNPPTLADGDIKES LQDHYSHNERVEYICQNFYQMEGEPYQTCINGEWFGKMRCLRPCTVDAEAMRRHNIAFKYRHADKLYAPHNDQIEFSCVR GKSSMRSRCIDGVMHLPTCF >XP_023820623.1 complement factor H-like isoform X1 [Oryzias latipes] MWILSFLLLTWFPAVLHAQGAAGSCARPELTHGFLVPDRQSYPENSVTYACDDGFKSAMESWWGTTTCQNGKWFPEPFCI DENSCVPPKISGGKCLTTSGWFEENDKLTVDCDPGYRLTKAFPQPTCIKGSWTSIPTCEKKKGACDRPPKISNATILHEA SQEVFAEGSKLQYECKTGHNTEDGKTQESITCRAGWWMTPLPCSRVSPACVMRQGQYTDFKLTKDELLMEGEIRSFNCGY PGYEKRARCINSEIFLTHCCHTSYVGSRDCHFVNRA >tr|E2FHP6|E2FHP6_DANRE Complement factor H-like 2 protein OS=Danio rerio OX=7955 GN=cfhl2 PE=2 SV=1 MNVPAKLLGFVVWLLCLNCGQCEDCLGTDINYENVEPVLEWSYPDGKTVRVTCQTGYTGM YRLRCEDGKWSENIARPCAKKRCSHPGEAANADFKLLDGTEYVFGTTVVYTCKKGYKMKS RINHRTCRSQGWDNAIPVCEAVTCELTSNYEVKRVVPEGKTIFRAGERLTITCTEKTWFR SKETIKTFACQDDGTWDSNPGCEGMCARPDIPNAKIIGDLRQSYSTNSTIRYKCNPGFEP EETVQITCDHQAQWTGLQQCTAKQEVCPDVHVKNGFSQPLNKTVIFYACNKGYKPFNGEW WSSVTCVKGSWSDVPLCIRKEECGAFPSVQNGKLKLKDQETAEIDCDPGFISSTPSIKCN NGTWETPTCNEGVRCGIPPYVDNSVIISKPEVVYIHGSSVTYTCRSPFVMIGKSTVFCSN GKWEETPTCEARCLRPLENYMSLANDKDTYQDKEILNYQCLKPYDKIPEGGWICENGKWT GDFVCTSDICPPPPYIENGSHFSRNPDDKMPTEVYYECQAYYVLSERKQYYRCENGRWRT PPKCLKPCQITQDILEAHNMRPDQQTGYIKHGDYVDYYCQHRLIVRTGHYKKATCSDGKL EIESCE >XP_018891362.2 complement factor H-related protein 2 [Gorilla gorilla gorilla] MWLIVSVILISWISSVGEEAMFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRI TCAEEGWSPTPKCLRLCFFPFVENGHSDENNISCVERGWSTPPKCRSTVSAEKCGPPPPINNGDITSFPL SVYAPGASVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGD IVEFVCKSEYHPTKSHSFRAMCQNGKLVYPSCEEK >XP_009238002.1 complement factor H-related protein 2 isoform X1 [Pongo abelii] MWLMVSVILISRISSVGGEATFCDFPKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRI TCTEEGWSPTPKCLRLCFFPFVENGHSESSGQTHLEGDTVQIICNTGYRLQNNENNISCVERGWSTPPKC RSTVSAEKCGPPPPIDNGDITSFPLSVYAPGSSVEYQCQNLYQLEGNNQITCRNGQWSEPPKCLHPCVIS QEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSAYYPTKSHSFRAVCQNGKLVYPSCEEK >XP_034798898.1 complement factor H-related protein 2 [Pan paniscus] MWLMVSVILISRISSVGGEVSAEKCGPPPPIDNGDITSFPLSVYAPGSSVEYQCQNLYQLEGNNQITCRN GQWSEPPKCLDPCVISQEIMEKYNIKLKWTNQQKLYSRTGDIVEFVCKSGYHPTKSHSFQAMCQNGKLVY PSCEEK
Mafft alignment of selected proteins >NP_005657.1 complement factor H-related protein 2 isoform 1 precursor [Homo sapiens] M--------------WLLVS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILI--SR---ISSVGGEAM-FCDFPKINHGILYD--EEK YKPFSQVPTGEVFYYSCEYNFVSPSKSFWT---RITCAEEG-WSPT--PKC-----LRLC FF--P-FVENGHSESS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HLEGDTVQIICN-TGYRLQNN-ENNISC-VERGW--STP PKCRST------------------------------------------------------ -----ISAEKCGPP-PPIDNGDIT-SFLLSVYAPGSSVEYQCQNLYQLEGNN---QITCR NG-----QWSEP---------------------------PKCLDPC--VIS---QEIMEK YNIKLKWTNQQKLYSRTGDIVE----------FVCKSGYHPT-KSHSFRAMCQNGKLVY- --PSCEEK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_024206509.1 complement factor H-related protein 2 isoform X1 [Pan troglodytes] M--------------WLMVS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILI--SR---ISSVGGEAT-FCDFPKINHGILYD--EEK YKPFSQVPTGEVFYYSCEYNFVSPPKSFWT---RITCTEEG-WSPT--PKC-----LRLC FF--P-FVENGHSESS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HLEGDTVQIICN-TGYRLQNN-ENNISC-VERGW--STP PKCRSTDASCVNPPTVQNAHILSRQMSKYPSGERVRYQCRSPYEMFGDEEVMCLNGYWTE PPQCKDSTGECGPP-PPIDNGDIT-SFPLSVYAPASSVEYQCQNLYELEGNK---RITCR NG-----QWSEP---------------------------PKCLHPC--VIS---REIMEK CNIALRWTAKQKLYSRTGETVE----------FVCKHGYRLSPSSHTLRTTCWDGKLEY- --PTCVKR---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_019677270.1 complement factor H-related protein 2-like isoform X1 [Felis catus] M--------------LLLIS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VSCAHGQGR-TCGFPEIKHGNIYD--EDR YKHNFPVALGKYFYYSCDHSFASPSQSLWT---KITCTEEG-WSPT--PKC-----IRQC FF--P-WVENGHSASS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HQEGDTAKIVCD-TDYRLLNN-QSNITC-TESGW--SIP PKCSST------------------------------------------------------ -----DPKRKCGPP-PPIDNGDIT-SFPLSTYAPGSLVEYQCQSFYELQGNK---NIICS HG-----QWSEP---------------------------PKCLDAC--VIS---EEAMDK HNIQLRWRHEKKFYSKTGDIIE----------FVCKSGYHKKTPHHTFRITCQEGKLEY- --PTCVKNNG-------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >NP_001037692.1 complement factor H-related protein 1 precursor [Rattus norvegicus] M---------GFCRLLFLVN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VLLT--SW---FSSAKGEGI-HCDFPKIRHGIVYD--EKK YEPFSPVPGGKILYYSCEYNFASPSSSFWN---PIICTEAG-WSPV--PKC-----LRIC FF--P-SVENGHSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HKEGDIVQIVCN-QGYSLQNN-QSTITC-GEEGW--SIP PKCISP------------------------------------------------------ -----NSAGKCGPP-PSIDNGDIT-SLSLPEYAPLSSVEYQCQNYFLLKGNK---IITCR NG-----KWSDP---------------------------PTCLHAC--VIP---EDILEK HNIVLRWRENGRIYSQSGENIE----------FMCKPGYRKLRGSPPFRSKCIDGHINY- --PTCL------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >KAB0344555.1 hypothetical protein FD754_021481 [Muntiacus muntjak] -----------MSNKLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGQGR-MCDFPEIKHGSIYN--ENK YKKIFPADVGKYFYYTCDHSFVTPSQSLWT---RINCTEGG-WSPA--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDIVHIVCD-TGYSLPNG-QSNITC-GERGW--SSP PECRRV------------------------------------------------------ -----YSQGRCGPP-PPIDNGDTT-SFPLPQYPPGSAVEYQCQAYYVLQGDR---YIVCR NG-----EWSEP---------------------------PKCLDPC--VIS---EEMMKQ HNIQLKWKNDKKIYTRTDDTIE----------FTCKRGYRPRTPNHTFRTTCQKGKLAY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_020771892.1 complement factor H-related protein 2-like [Odocoileus virginianus texanus] MNVP-----LRMSNKLLLRN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGQGR-TCDFPEIKHGSIYN--ENK YKKIFPADVGKYFYYTCDHSFVTPSQSLWT---RINCTERG-WSPA--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HQEGDVVHIVCD-TGYSLPNG-QSNIAC-GEGGW--SSP PECRRV------------------------------------------------------ -----YPQGRCGPP-PPVDNGDTT-SFPLSQYPPGSAVEYRCQAYYVLQGER---HIVCR NG-----EWSEP---------------------------PKCLDPC--VIS---EEMMKQ HNIQLKWRDDKKIYTRTDDTIE----------FMCKHGYRPRTPNHTFRTTCQKGILVY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >KAB0377273.1 hypothetical protein FD755_011717 [Muntiacus reevesi] -----------MSNKLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---LCCAHGQGR-MCDFPEIKHGSIYN--ENK YKKIFPADVGKYFYYTCDHSFVTPSQSLWT---RINCTEGG-WSPA--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDIIHIVCD-TGYSLPNG-QSNITC-GERGW--SSP PECRRV------------------------------------------------------ -----YSQGRCGPP-PPIDNGDTT-SFPLPQYPPGSAVEYQCQAYYVLQGDR---YIVCR NG-----EWSEP---------------------------PKCLDPC--VIS---EEMMKQ HNIQLKWKNDKKIYTRTDDTIE----------FTCKRGYSPRTPNHTFRTTCQKGKLAY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_043341406.1 complement factor H-related protein 2-like [Cervus canadensis] MNVP-----LRMSNKLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGQGR-MCDFPEIKHGSIYN--ENK YKKIFPADVGKYFYYTCDHSFVTPSQSLWT---RINCTEGG-WSPA--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HQEGDTVHIVCD-AGYSLPNG-QSNITC-GERGW--SSP PECRRV------------------------------------------------------ -----YPQGRCGPP-PPVDNGDTT-SFPLTQYPPGSAVEYQCQAYYVLQGDR---YIVCR NG-----EWSEP---------------------------PKCLDPC--VIS---EEMMKQ HNIQLKWRDDKKIYTRTDDTIE----------FTCKRGYRPRTPNHTFRTTCQKGKLVY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_020937508.1 complement factor H isoform X7 [Sus scrofa] MHVPLGI--PNMLSLINVLH---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VLLS--LW---VSCAHGQGR-TCDLPEIKHGRIYD--ENR YKQVFPVNVGQYFYYTCDHSFVSPSQLLWS---RITCTDAG-WSPT--PKC-----LRQC FF--P-WVENGLSASS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDTVQIACD-PGYRLANN-QSSITC-AEGGW--SSP PKCSPA------------------------------------------------------ -----YSQGKCGPP-PPIDNGDTT-SFPLPVYPPGTVVEYQCQSYYELEGSS---SIKCE NG-----QWSEP---------------------------PKCLDAC--VVS---EEMMRK HNIELKWTLGKKLYSRTDDTIE----------FRCRQGFYRRTPLHTFRVTCQQGKLAY- --PTCG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_004013976.1 complement factor H-related protein 2 [Ovis aries] -----------MSNMLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGQGR-MCDFPEIKHGSIYN--ENR YKKFFPTDVGKYFYYTCEHSFVTPSQSLWT---RINCTEEG-WSPT--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDIVHIVCN-AGYSLPNG-QSSIAC-GESGW--SSP PVCRRV------------------------------------------------------ -----YPQGRCGPP-PPIDNGDTV-SLPLPQYPPESAVEYKCQAYYVLQGDK---HIVCR NG-----EWSEP---------------------------PKCLGAC--VIS---EEMMQQ HNIQLKWRQDKKLYTRTDDSIE----------FTCKYGYRPTTPNHTFRTTCHEGKVVY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_005691103.1 PREDICTED: complement factor H-related protein 2 [Capra hircus] MNVP-----LRMSNMLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGQGR-TCDFPEIKHGSIYN--ENR YKKSFPADVGKYFYYTCEHSFVTPSQSLWT---RINCTEEG-WSPT--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDVVHIVCN-AGYSPPNG-QSSIAC-GESGW--SSP PECRRV------------------------------------------------------ -----YPQGRCGPP-PPIDNGDTV-SLPLPQYPPESAVEYKCQAYYVLQGDK---HIVCR NG-----EWSEP---------------------------PKCLGAC--VIS---EEMMQQ HNIQLKWRQDRKLYTRTDDNIE----------FTCKYGYRPTTPNHTFRTTCHEGKVVY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_002694314.1 complement factor H-related protein 2 [Bos taurus] MNLP-----LRMSNMLLLLN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILT--LW---VCCAHGRGK-TCDFPEIKHGSIYN--ENR YKKIFPADVGKYFYYTCEHSFVTPSQSLWT---RINCTEEG-WSPT--PKC-----LRQC FF--P-WVENGQSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HREGDIVHIVCD-TGYSLPNG-QSNITC-GERGW--SSP PECRHV------------------------------------------------------ -----YPRGRCGPP-PPIDNGDTV-SFPLSQYPPGSAVEYQCQAYYVLQGNR---HIVCR NG-----EWSEP---------------------------PKCLDAC--VIS---EEMMKQ HNIQLKWRDDKKLYTRTDDTIE----------FTCKRGYRPTTPIRTFRTTCHEGKVVY- --PHCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_008266942.1 PREDICTED: complement factor H isoform X10 [Oryctolagus cuniculus] MRLPAKV-------LWFVICTV-CVA-QDCKEPPPKKNIEILSGSWNEQTYPEGTQAVYK CRPGYRTLGTIVMTCRNGEWVAVNPARVCRKKPCGHPGDTPFGSFHLAVGNEFEFGAKVV YTCNEGYRMLGDIDYRECAVDGWTNDIPLCEVVKCLPVKEPENGKII--SELEPDQEYFF GQVIQFECNSGFKLDGDKQIHCSENGIWSGIKPQCVEISCNSPVITNGHSLSQKKIYKKN ERFQYKCNPGFEYTERGDAVCTSSGWSPEPSCKEVTCNAPYIPNGSYLPKRIQHRTGDEI KYECKTG--FYPATRGNTARCTGS--GW---VPGPRCSLK-PCDFPQINHGRLYY--EDR YRPYFPVAVGNYYSYHCNPNFVTPSNSYWD---YIHCTKEG-WSPK--VPC-----LRKC TF--S-YVENGYRPSS-------------ERP---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------YLQNESVKVDCY-PGYSLPNE-QTEITC-TENGW--SPL PKCIRV------------------------------------------------------ -----NSTGKCGPP-PPIENGDIT-SLSLPVYTSGSSVEYQCQSLYRLEGDK---KIMCR NG-----KWGKP---------------------------PKCLHAC--VIS---EEIMEK YNITLKWKERQKLYSQTGDTVE----------FICKYGYHPT-TSQSFRKTCQDGKLEY- --PSCAKKAG-------------------------------------------------- ------------------------------------------------------------ ------------------------RYYHY------------------------------- ----------------- >XP_030839713.1 complement receptor type 2 [Strongylocentrotus purpuratus] MELEPYI--------IFVIS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------TVVGM-AW-----GQTCTIN-ECSEESLPKPMGSGLSGYT PGGTGCYDDGTLVTYICTGSLLGPP--------TSQCSAGI-WFPPVGPTC---EAASGC FR--PQLPPNGNVTEY-------------KDEYALYDRITFYCD-----DGYSIIGPQE- --------------VVCDSGG--IWDP-SNIPTCEAS----------------------- ------------------------------------------------------------ -----------------------------------------------C-TAPSI-QNGGP NGT--------------------------------------------------------- ------------------YVNGEVITYTCDVNYTLIGVS----SATC-RDELWD----PT --NVPECL---------------------------------------------------- ------------------------------------------------------------ -------------------------------------------------------EQC-L PPIVANS-NFDTQQDL-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------FDHGSSVIIDCD-PGYSTGSSTSTTVNC-NDGSLS-MES PRCYEN------------------------------------------------------ ----------CSPL-DTFLNGQVT-GDTSPFY-HTETVSFSCDTGFTLDGAT---SITCS DG-----AWDAP--------------------------QPMCMDQCPVIVP---EAYSAF YGSAPPF--------QHGDMVT----------FTCYSGYEI--YNGSITSTCQNGQWSS- DPPFCTEQTTTTQAASTMMDSITTKLPSTSMTTLQDTVTPSTSQS--------------- SDTSPEAASTDVVLQTDKDLNTSRV----YRQVTFNQHDDYTRYNVAVYPNVNRSGIYRR PSNVFRDHYRSCHRNEDLNTRRVYRQFTFNQHEDCTRYNVTVYFPNFPNVNRSGIYRRPS NVES----------HHD >XP_038073060.1 low-density lipoprotein receptor-related protein 2-like [Patiria miniata] MDGTGGSR-KRWCLQHFLLS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VLLT--TF---RTAHAGD---FALIADLNNGTIYA----- ------GSMGRSLVDLAPLPLSG----------IVRPVTVD-FDPQ--ERMIYWSDLRSQ PS--P-KISRANLDGSNQMTIAENLRLPDGLALDVEARILYWTDGVLGHVGRASMNGTGN KEIIVENLDQPRTIVTDHSHGHIYWTDWGSSPRIERA----------------------- ---------------DLDGGNRTSVVDSDLH--W-------------------------- -------------------------------------------------------PNGVT IDA-DYLY----------------------------------W------CDAFLNKIERS DLSGQNRELVIDLNPYGDLHPYDLDVYRGDVYWTDWKVN---TLIRVSLNGRGEGNFGPS TFQQPGGIHI----E--------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------EEPDHCDS SPCDNGA-PCEDVIGGF---------LCQCPPGLQGTT-----------------CSDA- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------TSCVLPP DPSDVLMVVSGQQAVYLPGDSVQYACPDGYQLSGSTTRICLSDLTWSGQQPTCS-LTVVG CAPPTPDPSDVLMVVSGGQAVYHPGDSVQYACP-DGYQLSG--SATRICLSDFTWA-GEA PVCQDE---------------L-------------------------------------E PT---PDVSGCTPPTPGPSDVLMVVSDQRAVYLPGDSVQYACPDGYQLSGSA---TRICR SD----FTWAGE--------------------------APQCMEDDPATVSGCTPPTPDP SDVLMVVSDQRTVY-QLGDSVQ----------YACPDGYQL---SGSATRRCRSDFTWTG QAPQCKKEDPISGKSTGAIPVAIIAGGSGGAVLFLVAV---------------------- -------AIICVVAITVKRRRRRRFGGR-------VPISDIADRTC-------------- ---------KEVFPKE------YSTYVHYEKHIAEPLYSETLF----------------- ----------------- >XP_031560273.1 CUB and sushi domain-containing protein 3-like isoform X2 [Actinia tenebrosa] M--------------LFTKE---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------KVLVLM-VFVFALFKPKTDAS-TCSTLSIKLPLKAR----H VGSSTWFGAGDVLKFHCESSGATKPYYKLKGVIKIECQKDGTWSSKI-PIC----AASAC PAVGP-SVPNAQLLTT----------IIPGGTNNFGNRINYRCN-----LGFKLGSSSSN --------------KICQKNG--YWE---------------------------------- -----------------------------------GN-VTCV------------------ --------------------------------------------GIVC-PLPSI-NYGNV TYS-SLGY--GSVANYTCDKGYAVNGQPIRICDKSG-----HWSGNTPLC---LRLCPQL SAPTNGYIKNL-VDYLASREVGATIRFVCNPNYRMRGNK----FRTCEANGRWSG----- --QQPKCV---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------INTCGS PGPFSNG-VMTSSLPN-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------YIIGTVVNFSCH-SGYKLIGD-VSRRTCMHDGHWTGIQN PTCK-------------------------------------------------------- -------ILFCEEP-GNIFYGSH--DKHSDKYSYGSSVSYSCDSRYYLWGNA---TLTCQ AVSSGLTYWSGSIPSCLTLPRFEEKCVRLKGKFKVEHGRPICLFPA--TTA---THLKGE RKADRELDTLTIVTASAGSTLGALVILLSVMVFVRRFHRSRRFRNHSIRSRFYSDDDHVT LIATCREDVHFALPSYDEAMSQVQRDPPPFETVVQSNGVGPTN----------------- -NNSPVLPITGVASNPEGRDDRDNPSAHAQNENSADQHINIVNNPM----NENSS----E GTSLLS---QVANQGE---TPSEQPQESFVMNTLSSEESLVES---DPTSSREGLNLSVS EDEQSINESQPLIISNT >EDL39525.1 mCG9172 [Mus musculus] M---------GFCRLLLLAI---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VLLT--SW---FSTAKGEVS-LCDFPKIRHGILYD--EKK NEPFSSVLSGKILYYSCEYNFASPSNSFWT---RITCTESG-WSPT--PKC-----LRLC FF--P-FVENGNSTSS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HVEGDIVQVVCN-QGYSLQNN-QSTITC-AEEGW--SIT PKCIST------------------------------------------------------ -----NPTGKCGPP-PPIDNGDIT-SLSLPVYASLSSVEYQCQKYYLLKGNK---TITCR NG-----KWSEP---------------------------PTCIYPT-------------- -----------------GEMWA-------------------------------------- --PSTY------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_038526744.1 complement factor H-related protein 5 [Canis lupus familiaris] M---------------LLIN---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------AILI--LW---ISTVGGQGPFHCNFPKINHGIIYG--RED SEAFSPVPVGTIYYYSCEYNFASPSRSFWT---RIMCTEEG-WSPT--PKC-----LRLC FF--P-SVENGYSASS-------------GQTHLEGDIVQIICD-----VGYSLPYNDDT --------------ITCLENG---WS---PPPKCNST----------------------- ------------------------------------------------------------ --------------------------------------------NVEC-LLPVLEANVGV YPR-RVRYKTGEVLQFSCEQGLTGVGPASVQCYYFG------WSPSFPTCKGQVQSCGPP PQLLNGKIK---EARKEEYGHREMVEYDCDPYFLMTGPK----TIQC-MDGQWT------ --DLPTCT---------------------------------------------------- ------------------------------------------------------------ ----------------------------------------------------GQAKTCDY IPHFENG-YAQFSIPPF---RHGVSMKLNCRKTYTMIG-NNVITCIDGMWTELPTCVAT- ----DQLK------------------------SCRR------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P V-FSARILMYPHRNKFNHSTRVIYRCLGK---PGYKQTVC-INGQWH-PELHCKRDMEQL CPPPPQIPNAQNM-LTTVN--YQDKEKVAILCK-ENYLLHG--PRDIVC-KNGQW--QSL PRCIES------------------------------------------------------ -------TQYCGPP-PPVSNGDIT-SFPLSVYPPGSRVQYRCQSFYELRGST---DIICI NG-----QWSEP---------------------------PKCIDAC--IIY---EGNMNK NNIQLRGKNIRNLYVKTGDFVE----------FDCKQPYKAKTSMQSFRALCQEGKIEY- --PMCG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_019343938.1 PREDICTED: complement factor H-related protein 1 [Alligator mississippiensis] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------------------CGGPP I-VANANVVGKRNQRYQTGERVQYECQEHFEIMPSSYIVC-ANGEWS-QPPVCK---AMT CGPAPVIANGGIMGFGKQR--YFPGERVRYRCH-DGLSLIG--LQIITC-KDGIW--SQP PECKEA------------------------------------------------------ -------SGKCGTP-PPIDNGDIT-SFLLKEYESDSQVEYKCQHFYVMEGNN---ILTCV LG-----QWTDP---------------------------PICLEPC--TVS---EEEMEK NNIVLS--GEKKLYSLAGEAIE----------FECKTGYKRDPTSPALRAQCFEGKLQY- --PRCKIGS--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_014373981.1 complement factor H-like isoform X2 [Alligator sinensis] MSSIAGAGFIFWILRMTLLR---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------YMFIQLLW---AYSSQAEVQ-PCDYPQVENIELSGYYQSN RERAFPAKTGSSMYYRCAQGYVTATEENWV---LIRCTRDG-WDPA--PKC-----IKTC SF--P-RLENGRINYS------------SWRKFKEGETTSYSCY-----QGYSPENEQDR --------------ITCTKNG---LS---PTPRCILD-PTCHADHLENGRFLGNY-WRTS YKINERMTYSCNSENDRENQQRT--VTCTKNG-WWPT-PRCIPDKTCTRPNLENILLKTN KTVFSLGHDLIYECVVGYQTIHKITIDYTVCGRNG-WIPEPQCLAIEC-EMLTL-PNGEM SPR-KGKYHNGDVVTFSCAKGYTRVGPDSAQCYYFG------WSPAPPLCKDELRFCEQP PAIHNGSII---SECQQQYPHGSTMEYRCNHRFKMIGSS----KIEC-IDGAWS------ --PLPSCT------E--------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------AKKKCPP PPQVPGA-LKVTEMRNY---ESGEEIPFQCLENFEASAEVDKIMCKDGKWQSPPRCIEK- -------------------------------YVCRS-----------------------P RPLENGK--------------LRQEHQNLGM----------------EQSG--------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------------P I-------------TYPDGAVLEYTCNTGFVLNGRSEITC-NMGTWT-AAPTCD---EMP CGKVPSVLHSLPRRGEKNH--YEAGITVRYECK-RGFKIHG--EQNIIC-QAGNW--TKP PTCEEF------------------------------------------------------ -------FGKCGPP-PAIENGDIT-SFPLKQYEQDSRVEYKCQHLYVMEGSQ---FATCN VG-----EWTEP---------------------------PTCIEPC--TVS---EEDLEK NNIKLKWTPVGKLYSASGDFIE----------FVCKEGYVKDPTSPPFRVQCLKGKLSY- --PQCR------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------L >XP_025008854.1 complement factor H isoform X2 [Gallus gallus] M--------PFLGYAALLLCWMYCTAERACEQSPPRRVKEIPTETWDNPPYPHGTLVTYK CRPGYIKIGRIVVKCADGVWKQQGNTE-CRSKPCGHPGDIEFGSFQLTAGNEFVFGARVE YRCNDGYRMLSQKNYRECLAEGWSNDIPHCEVAKCLPVKAPENGRIVLSGAFELNREYSF GEVMEFECNEHYRLVGSKAIHCSSNGKWDSDVPQCQDIICNVPSIPNGVVRSSQKTYRES EQLHYVCNKGYTYGERADAQCTESGWSPTPYCTEVVCFPPTFRNGNFRPQKDRYTEGATI TIDCDLGYRYSTLTAKNVAKCTSS--GW---VPAPGCVEK-PCDYPAVENIRLSG---NW QQNYFPMRIGQTIYYRCREGYLTPSEEYWV---HIVCSQGG-WKPE--PQC-----LKRC DV--G-PLENGYIQNN------------WKRYFKEGERTKYFCN-----KNYRTENEDGE --------------ITCSKNG---WS---PTPRCIRK-ETCQWVDLTNGYFMER---RAT FDIGETVSYSCYNDFVTPEKQKMGMIQCQKNG-WSPP-PKCI------------------ --------------------------------------------PIEC-KLPVL-SHGQA HPS-KNTYYNGDVVKFICVKNYIRVGPASSQCYYFG------WFPSPPTCKVDPRDCGPP PEITNGNVI---GGFLERYQHGNRMEYECDTPFTLVGSK----EIEC-LDGQWS------ --SLPSCI------ENKMP-------------------------CGSPSSVLNVVLLQQD RAQFSHGDEVTYRCSQGSENATRMRTKCLNGEWKPSPLCNDPFHQCVTPEDIVIERTGSH RKAKETGLYL-----TYKCKPADRQFKQATCVSG----------KWTPEIQCTGESTCPL PPQLPNA-NKIPIGRNY---KNGSKIAFSCLEGFHLIG-ANEIMCINGKWQSPPYCVEK- --------------------------------PCSP-----------------------P QPVEHADD-------------VRLVNQSLKM----------------EKEG--------- ---------KTVYLAGAVVKFTCHSGFELDGPSEISC----------------------- -----------------SMGNWSSY-----------------------PTCS-EASCGSI PNVPNSAIEGRNKEAYEPGETIRYQCDEGFEAVGVPEIICRKGNWSTPPFCEDVSCEAPP E-IHNAYITSPQQQRYLPGARVQYECDSHFQITAVNYVTC-SNGQWL-QTPTCK---DTR CGPPPEISGGKVQGFKKSR--YLPGETAKYECW-KGFRMTG--ASTVSC-QNGTW--TEL PTCKGK------------------------------------------------------ -------SEKCGPP-PDIENGDIL-SFPMPEYSQGETLKYKCPNLYILEGSQ---QITCI NG-----QWTNP---------------------------PVCLVAC--TAA---EEDMNN NNIELKWREESKLYSRPGDFIE----------FDCKIGNVEDPASSPFRVQCINGTFKY- --PRCNPGRD-------------------------------------------------- ----------CRVLESEMDKNNIQLQ---WRMPHTYRSKERISFKC-------------- ---------KWLYEP-------VSRPEKF--KPRC-LDGVIEY----PQCAY-------- --------------RWK >XP_010713972.1 complement factor H [Meleagris gallopavo] M----------------------------------------------------------- ------KIGRIVVKCADGEWKQQGNTE-CRSKPCGHPGDTEFGSFQLTAGKEFVFGARVE YRCNDGYRMLSQKNYRECLAEGWSNDIPHCEVAKCLPVKAPENGRIVVSGAFELNREYSF GQVIEFECNEHYRLVGSKAIHCSSNGRWDSDVPQCQDIICSVPSIPNGNVRSSQKTYKES EQLHYVCNKGYTYGERANVQCTESGWYPTPYCTEVVCFPPTFRNGNFRPQKDRYIEGATI TIDCDSGYRFSTLTAKNVAKCTSN--GW---VPAPGCIEK-PCDYPAVDNIMLSR---NW QQNYFPMRIGQTIYYGCRQGYLTPTEQYWI---QIVCSPGG-WKPE--PQC-----LKIC DV--R-YLENGVMQSN------------WRRYYKEGERAKYFCN-----TNYRTDSEDGE --------------ITCTKNG---WS---PTPRCIRK-ETCQYVDLTNGYFLKN---KAT FDIGETVTYRCYNDFVTPERQEIGEIQCQVAG-WSPP-PKCI--QFCKTPQTRVLTDCTT RKIYLPGDTLEYACHEQYHTADNMPTGTTMCGVNGEWKPAPQCVAIEC-ELPEL-SNRVV HPA-KSRYYNGDVVKFSCIDNHVRVGPASAQCYYFG------WFPSPPTCKVNPRGCGPP PEVTNGNVT---GSFLEWYPNGNRMEYECDTQFKLVGSK----EIEC-LDGEWS------ --SPPSCI------EDKMP-------------------------CGSPSSIPNIVLQQQY RVQFSHGEEVTYRCKQGSGNASRMRTKCLNGEWKPSPLCNAPSHQCVPPEDIVVVRTNSL RKAKETELYL-----TYKCKQADRQLKQATCVSG----------KWSPEIQCTGESTCPP PPQLPNA-NKIPVGRNY---KNGSKIAFSCLEGFHLIG-ANEITCINGKWQSPPYCVEK- --------------------------------PCSP-----------------------P QLIENADD-------------FRLVNQNLKM----------------EKEG--------- ---------KTVYLAGAVVKFICHSGFELEGPSEINC----------------------- -----------------SMGNWSSS-----------------------PTCS-EMSCGSI PNVHNSATEGRNKEVYEPGETIRYQCDEGFEAVGLPEIICRKGNWSTPPFCEDVTCEAPP E-IHSANIISTQQQRYLPGARVQYECDSNFQITGVNYVTC-TNGQWS-QTPTCK---DMR CGPPPEIAGGKVHGVKKSK--YLPGETAKYACW-EGFRMTG--ASTVGC-QNGTW--TEL PTCRGK------------------------------------------------------ -------SGKCGPP-PEIEYGDIL-SFPKAEYSQGETLKYKCPNLYILEGSQ---QIRCI NG-----QWTNP---------------------------PVCLVAC--TAA---EEDMNN NNIELKWREEKKLYSKPGDFIE----------FDCKIGNVKDPASSPFRVQCINGTLKY- --PRCNPGRD-------------------------------------------------- ----------CKVLHSEMDKNNIKLQ---LEERYIYRSNERISFTC-------------- ---------KWFQKA-------VSRPEKF--NPKC-LDGVIEY----PQCTR-------- --------------VIG >PKK27813.1 coagulation factor XIII B chain [Columba livia] M------------KMRFKSC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------FFFLVTMY---SGKLFAEDK-PCDLPHIENGKIAQYYYSF KSYYFPMHKEKKLSYSCMIGYTTESGTQDG---RITCTAKG-WSPV--PRC-----YKKC SK--P-LLENGFFYGT-------------ETYFKIEEKLQYKCN-----PGYHTPSGGTE DT------------VQCQPEG---WS---SQPSCAKKIESCQVPNLHHGSYFTD---RQE LRLNETLLYRCDEGYHTAGGNTTEEAVCLTHG-WSLP-PNCT------------------ --------------------------------------------KITCSSLSAI-AHGGF YPV-KKIYEEGDVVHFFCEENYSVTVFDLIQCYYFG------WYPDPPVCEGVKNKCPPP PLPPHAHII----TVKRTYHNGDKARIQCQSTVET--------EIQC-VEGKWS------ --SPPICIGAMDKREPEAPPPLEAQAAVRTSKTYHDEDTKMQQNCTSPPVIKNGVLLGPL LTSYKNGSSVEYSCQRYHFLEGPSTVYCEQGNWTEQPMCLEPCTLNVTDLD---SNNIEL KWRQEELIFLHGDLVEFECKQG-YNFLQTTVLSPGRTQCNHGRLKYPKCILQAPTEKCDS PPSIANGALTLPPLTQY---DSGSSVQYSCSDYHFLQG-SETIYCSEGQWTSPPVCIEPC TLSKDEMEKNNVLLQGFYGNQVYFYHGDYVGFYCKQNHFGAESGTTLFQVQCKRGQLTYP RCIESEADGPVARPVAFEELWMKHKNTCLEMALLSCTVVFLLWLGCTAHEGTACEDPPVI DFGEIISGNKSRYMERDRVQYMCNAGFTLSGSEWVTCHEKMWVPGPPQCLAPCIITKQQL QVKNLLLSDGQRHSFLIQSGRWQKFMCVTGFKLTAFPIRQCFNGHIKLPSCVIERPCGSI PKVANAQIEGRNKASYEPGETVSYQCDEGFLIVGTPEIICREGNWTAPPFCEDVTCGTAP E-IPNAHITSTQQERYLPGARVQYECESNFQMMDINYVTC-TNGQWS-RAPTCR---DVT CEPPPEIAGGKIEGVKKSR--YLPGESARYQCW-RGFQMTG--SASVTC-RTGNW--TEL PKCKGE------------------------------------------------------ -------GGKCGPP-PVIKNGDLL-SSPMQEYSPGTTLEYKCPSLYLLEGSQ---YITCT DG-----QWTSP---------------------------PVCLVAC--TAS---EEDMSS NNIELKWVRGRKLYSTSGDFVE----------FKCRRGYVKDPASSPFRVQCVEGTLEY- --PRCKPGRN-------------------------------------------------- ----------CILDKSTMEGNHIQLQSSKLSSMSTYRSGDYIDFEC-------------- ---------KWWHQK-------VSRAESF--RAEC-LDGVIQY----PTCEY-------- --------------VFG >XP_040215769.1 coagulation factor XIII B chain-like [Rana temporaria] MKC-----FRKREKNMGKFC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------FILL--AFAE-SFFYPAEGN-MCDLPKMENAVIAPYFYTF TKFYFPMKEGKTLSVACSAGHTFQSGMQEE---KITCTPEG-WDPP--AVC-----FKKC IQ--P-TLINGIVHNG-------------KDSYKTSETAQYSCF-----EGYTTKGGHKS EQ------------IQCSSGS---WD---PTPGCLQLSDRCVAPPLDNGIYTTT---KRN FRIKEIIQYQCNTGYYTASGSTADWAECLRHG-WSST-PHCA------------------ --------------------------------------------KSSCGKLANV-ENGGF HPV-KASYADRDVVQFSCKENYLTKGSELIQCYSYG------WDPEPPTCEERRKRCPPP PRPAHSILL----NNSALHHTGDIVHYECDDNYKLIGTE----KIHC-ENGQWT------ --TPPTCI------E--------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------LKEKIECGK PPPTDNG-TAVIEREI-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------YSSGDSIFYKCV-DGYEIQG--SNKIIC-RKGKW--TEP PKCKAN------------------------------------------------------ -------NEDCGSP-PKISQGELT-GAALARYTTGSSVEYRCHSYHLMEGTK---TVYCT RG-----TWLQL---------------------------PKCLEPC--TVS---VLDMKE RNVDLQWHFEINSKFLHGDMVE----------FKCMDGFDTS-THSELKGLCQNGHILY- --PSCSIKGTLKSCGTSPVVTHSTVNSSQKVYLSGSVVIYQCSEHYYLNGKSMVRCSNGL WEDPPICIEPCILSREEMSKNNIHLKWT-L-YSDYILHREFVDFLC-------------- ---------MAGYEN-------YETTLAFALRSEC-RYGQLKY----PKCVS-------- --------------RNR >XP_041446564.1 coagulation factor XIII B chain [Xenopus laevis] M-------------SVYKFC---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------ILLLC-HW-----FCFAQEN-GCDLPVVENGKIAQYYYVF KKFYFPMKEGKKLSLSCAAGYSTQSGKQEE---QITCKGVA-WEPA--SLC-----FKKC IK--P-SLNHGNVHNP-------------KDSYKFLERAHYSCL-----EGYVTVSGNQT EE------------VQCLANG---WS---SQPECHQISDGCEAPRLYNGHYTTT---KRA FHVKEILQYQCDEGYGTPSGRTADETECLLRG-WSSV-PQCT------------------ --------------------------------------------KQSCKELQPV-QNGGF YPV-KAMYVDRDVVQFFCTEGYILRDSELIQCYSFG------WYPEPPSCEEKSNKCPPP PRPAHIILL----TDPAVHRNGDSARYECDYNYMLIGSE----EIYC-ENGRWT------ --APPSCV------E--------------------------------------------- ------------------------------------------------------------ ---------------------------------------------------LKEKLKCAP PPYVENG-EVMLQAEV-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------YYSGDRVNFQCA-EGYEIQG--SSEIIC-KMGKW--PEP PKCKAK------------------------------------------------------ -------SDFCQIP-PPLTNGELI-DLPSLSYKNSESVEYRCKSYHLMEGPK---TVNCT HG-----KWTEL---------------------------PTCLEPC--TVS---VDLMRQ RNLELKWSFEMDTYFLHGDMIE----------FVCKDDLDMSEHPEGLKGMCQRGNIRY- --PTCSRKDKLNACGPPPLVKNGRVLAPQENYESGSSAVYMCSEHHFLNGSNTVQCSDGD WDHPPTCIEPCVLSKEEMERNQIRLRWS-FDNKDYFYHGEYIEFLC-------------- ---------IDGHEN-------TSPTIMFSLRAQC-SDGQIKY----PKCVL-------- --------------RAR >XP_015826626.1 PREDICTED: complement factor H-like isoform X3 [Nothobranchius furzeri] MWRVSLFGVQGCEKTMFTIA---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------KSVVLL--LWTQTFIFVKCQ---DCTLEQFLKSPNYDVNFET SGLAATYGPGKQVRVPCKIGFMGFY--------KLICSEGR-WVHRG-SIC----EIKSC GH--PGDAAFGDFRLE------------KKDDFVYGSQVVYECQ-----RGYHMVSRSNI --------------RRCQAEG---WD--GVVPVCEAI--RCPSIPLPDGMQVVGDLDEAT F--GNVVQFSCRNNSHVLEGSRV--LHCNENGEWQGTAPKCK------------------ --------------------------------------------EIKC-NAPVI-ENGRV EGN-RQEYKKDEWLTFSCNDGFKKVYDFRPKCQKLGQHGNAEWAPT-PACKKITCELSQP PPLGTAY-----STQNSVFLPRQTVRVTCGERYSIINTKTTEAVVTCQVDGEWD------ --TWRVCK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------EVTCSG HLPEDNL-SWTTNRNTWGRNRLGDTVSYSCAWSYERTDGAQHATCTRDGWTPKPLCRAT- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------SAPCPHP D-FENAVITYGGKDSYNRNDKVRYRCQTGNG--ETFTATC-REGAWT-ESTGCA----AS C-PPPDFQDADIIHGAKYN--YISDDQVQYRCK-SGNRE----TFTAIC-KEGTW--AEA KKCADQ------------------------------------------------------ -------SG-CGRP-PSLTDGETV-RFTKQQYENGDTVEYTCYNMYVLKGGR---FKTCN NG-----VWTGE---------------------------MRCMKPC--IVN---AEMMER HNIEFSRNDRDKYYAPHEDHLT----------FVCKHGTRLL-HQEPMRKQCINGQMDL- --PTCG------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_030289713.1 complement factor H-related protein 1-like isoform X4 [Sparus aurata] M-------------RLFHLL---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------WLFI--LWLKMEKSLQSDEV-LCDKPDIQ----------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----DADIIHNEKESYSDKEQVQFECKNGLE--KRFTVTC-EQGNWI-EIQSCA----AE C-QITGVPENVIITPNVQNNQLRSGQQLRFACRHPGHFLRG--NAAVECLAHGQWS-APF PTCGDP------------------------------------------------------ -------LG-CNNP-PTLADGDIK-ESLQDHYSHNERVEYICQNFYQMEGEP---YQTCI NG-----EWFGK---------------------------MRCLRPC--TVD---AEAMRR HNIAFKYRHADKLYAPHNDQIE----------FSCVRG------KSSMRSRCIDGVMHL- --PTCF------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_023820623.1 complement factor H-like isoform X1 [Oryzias latipes] M---------------WILS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------FLLL--TWFPAVLHAQGAAG-SCARPELTHGFLV------ ------------------------------------------------------------ ----P------------------------------------------------------- --------D--------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----RQSYPENS------------------------------------------------ ------------------------VTYACDDGFKSAMESW-WGTTTC-QNGKWF------ --PEPFCI---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------DENSC-V PPKISGG-KCLTTSGW-------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------FEENDKLTVDCD-PGYRLTKA-FPQPTC-IKGSW--TSI PTCEKK------------------------------------------------------ -------KGACDRP-PKISNATILHEASQEVFAEGSKLQYECKTGHNTEDGKTQESITCR AG-----WWMTP---------------------------LPCSRVS--------PACVMR QGQYTDFKLTKDELLMEGEIRS----------FNCGY------PGYEKRARCINSEIFL- --THCCHTSYV------------------------------------------------- ------------------------------------------------------------ ----------------------GSRDCHFVNRA--------------------------- ----------------- >tr|E2FHP6|E2FHP6_DANRE Complement factor H-like 2 protein OS=Danio rerio OX=7955 GN=cfhl2 PE=2 SV=1 MNVPA------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------KLLGFVVWLLCLNCGQCE---DCLGTDINYENVEPV---- --LEWSYPDGKTVRVTCQTGYTGMY--------RLRCEDGK-WSENIARPC----AKKRC SH--PGEAANADFKLL------------DGTEYVFGTTVVYTCK-----KGYKMKSRINH --------------RTCRSQG---WD--NAIPVCEAV--TCELTSNYEVKRVVPE-GKTI FRAGERLTITCTEKTWFRSKETIKTFACQDDGTWDSN-PGC------------------- --------------------------------------------EGMC-ARPDI-PNAKI IGDLRQSYSTNSTIRYKCNPGFEPEETVQITCDHQA-----QWTGL-QQCTAKQEVCPDV HV----------KNGFSQPLNKTVIFYACNKGYKPFNGEW-WSSVTC-VKGSWS------ --DVPLCI---------------------------------------------------- ------------------------------------------------------------ -----------------------------------------------------RKEECGA FPSVQNG-KLKLKDQE--------TAEIDCDPGFISST--PSIKCNNGTWET-PTCNEG- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------------------------VRCGIPP Y-VDNSVIISKPEVVYIHGSSVTYTCRSPFVMIGKSTVFC-SNGKWE-ETPTCE----AR CLRP--LENYMSLANDKDT--YQDKEILNYQCL-KPYDKIP--EGGWIC-ENGKW--TGD FVCTSD---------------I-------------------------------------- ----------CPPP-PYIENGSHF-SRNPDDKMP-TEVYYECQAYYVLSERK--QYYRCE NG-----RWRTP---------------------------PKCLKPC--QIT---QDILEA HNMR---PDQQTGYIKHGDYVD----------YYCQHRLIVR-TGHYKKATCSDGKLEI- --ESCE------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_018891362.2 complement factor H-related protein 2 [Gorilla gorilla gorilla] M--------------WLIVS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILI--SW---ISSVGEEAM-FCDFPKINHGILYD--EEK YKPFSQVPTGEVFYYSCEYNFVSPSKSFWT---RITCAEEG-WSPT--PKC-----LRLC FF--P-FVENGHSD---------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------ENNISC-VERGW--STP PKCRST------------------------------------------------------ -----VSAEKCGPP-PPINNGDIT-SFPLSVYAPGASVEYQCQNLYQLEGNN---QITCR NG-----QWSEP---------------------------PKCLDPC--VIS---QEIMEK YNIKLKWTNQQKLYSRTGDIVE----------FVCKSEYHPT-KSHSFRAMCQNGKLVY- --PSCEEK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_009238002.1 complement factor H-related protein 2 isoform X1 [Pongo abelii] M--------------WLMVS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILI--SR---ISSVGGEAT-FCDFPKINHGILYD--EEK YKPFSQVPTGEVFYYSCEYNFVSPSKSFWT---RITCTEEG-WSPT--PKC-----LRLC FF--P-FVENGHSESS-------------GQT---------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------HLEGDTVQIICN-TGYRLQNN-ENNISC-VERGW--STP PKCRST------------------------------------------------------ -----VSAEKCGPP-PPIDNGDIT-SFPLSVYAPGSSVEYQCQNLYQLEGNN---QITCR NG-----QWSEP---------------------------PKCLHPC--VIS---QEIMEK YNIKLKWTNQQKLYSRTGDIVE----------FVCKSAYYPT-KSHSFRAVCQNGKLVY- --PSCEEK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ----------------- >XP_034798898.1 complement factor H-related protein 2 [Pan paniscus] M--------------WLMVS---------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------VILI--SR---ISSVGGE---------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----VSAEKCGPP-PPIDNGDIT-SFPLSVYAPGSSVEYQCQNLYQLEGNN---QITCR NG-----QWSEP---------------------------PKCLDPC--VIS---QEIMEK YNIKLKWTNQQKLYSRTGDIVE----------FVCKSGYHPT-KSHSFQAMCQNGKLVY- --PSCEEK---------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ -----------------
BMGE Cleaned alignment of selected proteins >NP_005657.1 complement factor H-related protein 2 isoform 1 precursor [Homo sapiens] -WLLVSFCDFPKINHGILYDTGEVFYYSCENFVSPSKSFWTRITCAEEGLRLCFFFVENGHHLEGDTVQTGYRLQNNVERGWPPKCRAEKCGPPPPIDNGDITSFLLSVYAPGSSVEYQCQNLYQLEGNTCRNGQWSEPPKCLDPCYNIKLKWTGDIVEFVCKSGYSFRAMCQNGKLV >XP_024206509.1 complement factor H-related protein 2 isoform X1 [Pan troglodytes] -WLMVSFCDFPKINHGILYDTGEVFYYSCENFVSPPKSFWTRITCTEEGLRLCFFFVENGHHLEGDTVQTGYRLQNNVERGWPPKCRTGECGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYELEGNTCRNGQWSEPPKCLHPCCNIALRWTGETVEFVCKHGYTLRTTCWDGKLE >XP_019677270.1 complement factor H-related protein 2-like isoform X1 [Felis catus] -LLLISTCGFPEIKHGNIYDLGKYFYYSCDSFASPSQSLWTKITCTEEGIRQCFFWVENGHHQEGDTAKTDYRLLNNTESGWPPKCSKRKCGPPPPIDNGDITSFPLSTYAPGSLVEYQCQSFYELQGNICSHGQWSEPPKCLDACHNIQLRWTGDIIEFVCKSGYTFRITCQEGKLE >NP_001037692.1 complement factor H-related protein 1 precursor [Rattus norvegicus] LLFLVNHCDFPKIRHGIVYDGGKILYYSCENFASPSSSFWNPIICTEAGLRICFFSVENGHHKEGDIVQQGYSLQNNGEEGWPPKCIAGKCGPPPSIDNGDITSLSLPEYAPLSSVEYQCQNYFLLKGNTCRNGKWSDPPTCLHACHNIVLRWSGENIEFMCKPGYPFRSKCIDGHIN >KAB0344555.1 hypothetical protein FD754_021481 [Muntiacus muntjak] KLLLLNMCDFPEIKHGSIYNVGKYFYYTCDSFVTPSQSLWTRINCTEGGLRQCFFWVENGQHREGDIVHTGYSLPNGGERGWPPECRQGRCGPPPPIDNGDTTSFPLPQYPPGSAVEYQCQAYYVLQGDVCRNGEWSEPPKCLDPCHNIQLKWTDDTIEFTCKRGYTFRTTCQKGKLA >XP_020771892.1 complement factor H-related protein 2-like [Odocoileus virginianus texanus] KLLLRNTCDFPEIKHGSIYNVGKYFYYTCDSFVTPSQSLWTRINCTERGLRQCFFWVENGQHQEGDVVHTGYSLPNGGEGGWPPECRQGRCGPPPPVDNGDTTSFPLSQYPPGSAVEYRCQAYYVLQGEVCRNGEWSEPPKCLDPCHNIQLKWTDDTIEFMCKHGYTFRTTCQKGILV >KAB0377273.1 hypothetical protein FD755_011717 [Muntiacus reevesi] KLLLLNMCDFPEIKHGSIYNVGKYFYYTCDSFVTPSQSLWTRINCTEGGLRQCFFWVENGQHREGDIIHTGYSLPNGGERGWPPECRQGRCGPPPPIDNGDTTSFPLPQYPPGSAVEYQCQAYYVLQGDVCRNGEWSEPPKCLDPCHNIQLKWTDDTIEFTCKRGYTFRTTCQKGKLA >XP_043341406.1 complement factor H-related protein 2-like [Cervus canadensis] KLLLLNMCDFPEIKHGSIYNVGKYFYYTCDSFVTPSQSLWTRINCTEGGLRQCFFWVENGQHQEGDTVHAGYSLPNGGERGWPPECRQGRCGPPPPVDNGDTTSFPLTQYPPGSAVEYQCQAYYVLQGDVCRNGEWSEPPKCLDPCHNIQLKWTDDTIEFTCKRGYTFRTTCQKGKLV >XP_020937508.1 complement factor H isoform X7 [Sus scrofa] LINVLHTCDLPEIKHGRIYDVGQYFYYTCDSFVSPSQLLWSRITCTDAGLRQCFFWVENGLHREGDTVQPGYRLANNAEGGWPPKCSQGKCGPPPPIDNGDTTSFPLPVYPPGTVVEYQCQSYYELEGSKCENGQWSEPPKCLDACHNIELKWTDDTIEFRCRQGFTFRVTCQQGKLA >XP_004013976.1 complement factor H-related protein 2 [Ovis aries] MLLLLNMCDFPEIKHGSIYNVGKYFYYTCESFVTPSQSLWTRINCTEEGLRQCFFWVENGQHREGDIVHAGYSLPNGGESGWPPVCRQGRCGPPPPIDNGDTVSLPLPQYPPESAVEYKCQAYYVLQGDVCRNGEWSEPPKCLGACHNIQLKWTDDSIEFTCKYGYTFRTTCHEGKVV >XP_005691103.1 PREDICTED: complement factor H-related protein 2 [Capra hircus] MLLLLNTCDFPEIKHGSIYNVGKYFYYTCESFVTPSQSLWTRINCTEEGLRQCFFWVENGQHREGDVVHAGYSPPNGGESGWPPECRQGRCGPPPPIDNGDTVSLPLPQYPPESAVEYKCQAYYVLQGDVCRNGEWSEPPKCLGACHNIQLKWTDDNIEFTCKYGYTFRTTCHEGKVV >XP_002694314.1 complement factor H-related protein 2 [Bos taurus] MLLLLNTCDFPEIKHGSIYNVGKYFYYTCESFVTPSQSLWTRINCTEEGLRQCFFWVENGQHREGDIVHTGYSLPNGGERGWPPECRRGRCGPPPPIDNGDTVSFPLSQYPPGSAVEYQCQAYYVLQGNVCRNGEWSEPPKCLDACHNIQLKWTDDTIEFTCKRGYTFRTTCHEGKVV >XP_008266942.1 PREDICTED: complement factor H isoform X10 [Oryctolagus cuniculus] LWFVICPCDFPQINHGRLYYVGNYYSYHCNNFVTPSNSYWDYIHCTKEGLRKCTFYVENGYYLQNESVKPGYSLPNETENGWLPKCITGKCGPPPPIENGDITSLSLPVYTSGSSVEYQCQSLYRLEGDMCRNGKWGKPPKCLHACYNITLKWTGDTVEFICKYGYSFRKTCQDGKLE >XP_030839713.1 complement receptor type 2 [Strongylocentrotus purpuratus] -IFVISECSEESLPKPMGSGDGTLVTYICTSLLGPP-----TSQCSAGIASGCFRLPPNGNFDHGSSVIPGYSTGSSNDGSLSPRCY---CSPLDTFLNGQVTGDTSPFY-HTETVSFSCDTGFTLDGATCSDGAWDAPPMCMDQCYGSAPPFHGDMVTFTCYSGYSITSTCQNGQWS >XP_038073060.1 low-density lipoprotein receptor-related protein 2-like [Patiria miniata] QHFLLSFALIADLNNGTIYAMGRSLVDLAPPLSG-------IVRPVTVDLRSQPSKISRANYHPGDSVQDGYQLSG-SDFTWAPVCQVSGCTPPPGPSDVLMVSDQRAVYLPGDSVQYACPDGYQLSGSICRSDTWAGEPQCMEDDSDVLMVVLGDSVQYACPDGYSATRRCRSDFTW >XP_031560273.1 CUB and sushi domain-containing protein 3-like isoform X2 [Actinia tenebrosa] -LFTKETCSTLSIKLPLKARAGDVLKFHCESGATKPYYKLKKIECQKDGASACPASVPNAQYIIGTVVNSGYKLIGDHDGHWNPTCKILFCEEPGNIFYGSH-DKHSDKYSYGSSVSYSCDSRYYLWGNTCQAVYWSGSPICLFPARKADRELAGSTLGFVRRFHRSIRSRFYSDDDH >EDL39525.1 mCG9172 [Mus musculus] LLLLAILCDFPKIRHGILYDSGKILYYSCENFASPSNSFWTRITCTESGLRLCFFFVENGNHVEGDIVQQGYSLQNNAEEGWTPKCITGKCGPPPPIDNGDITSLSLPVYASLSSVEYQCQKYYLLKGNTCRNGKWSEPPTCIYPT--------GEMWA------------------- >XP_038526744.1 complement factor H-related protein 5 [Canis lupus familiaris] --LLINHCNFPKINHGIIYGVGTIYYYSCENFASPSRSFWTRIMCTEEGLRLCFFSVENGYYQDKEKVAENYLLHG-KNGQWLPRCITQYCGPPPPVSNGDITSFPLSVYPPGSRVQYRCQSFYELRGSICINGQWSEPPKCIDACNNIQLRGTGDFVEFDCKQPYSFRALCQEGKIE >XP_019343938.1 PREDICTED: complement factor H-related protein 1 [Alligator mississippiensis] -------------------------------------------------------------YFPGERVRDGLSLIG-KDGIWPPECKSGKCGTPPPIDNGDITSFLLKEYESDSQVEYKCQHFYVMEGNTCVLGQWTDPPICLEPCNNIVLS-AGEAIEFECKTGYALRAQCFEGKLQ >XP_014373981.1 complement factor H-like isoform X2 [Alligator sinensis] RMTLLRPCDYPQVENIELSGTGSSMYYRCAGYVTATEENWVLIRCTRDGIKTCSFRLENGRYEAGITVRRGFKIHG-QAGNWPPTCEFGKCGPPPAIENGDITSFPLKQYEQDSRVEYKCQHLYVMEGSTCNVGEWTEPPTCIEPCNNIKLKWSGDFIEFVCKEGYPFRVQCLKGKLS >XP_025008854.1 complement factor H isoform X2 [Gallus gallus] AALLLCPCDYPAVENIRLSGIGQTIYYRCRGYLTPSEEYWVHIVCSQGGLKRCDVPLENGYYLPGETAKKGFRMTG-QNGTWLPTCKSEKCGPPPDIENGDILSFPMPEYSQGETLKYKCPNLYILEGSTCINGQWTNPPVCLVACNNIELKWPGDFIEFDCKIGNPFRVQCINGTFK >XP_010713972.1 complement factor H [Meleagris gallopavo] ------PCDYPAVDNIMLSRIGQTIYYGCRGYLTPTEQYWIQIVCSPGGLKICDVYLENGVYLPGETAKEGFRMTG-QNGTWLPTCRSGKCGPPPEIEYGDILSFPKAEYSQGETLKYKCPNLYILEGSRCINGQWTNPPVCLVACNNIELKWPGDFIEFDCKIGNPFRVQCINGTLK >PKK27813.1 coagulation factor XIII B chain [Columba livia] MRFKSCPCDLPHIENGKIAQKEKKLSYSCMGYTTESGTQDGRITCTAKGYKKCSKLLENGFYLPGESARRGFQMTG-RTGNWLPKCKGGKCGPPPVIKNGDLLSSPMQEYSPGTTLEYKCPSLYLLEGSTCTDGQWTSPPVCLVACNNIELKWSGDFVEFKCRRGYPFRVQCVEGTLE >XP_040215769.1 coagulation factor XIII B chain-like [Rana temporaria] NMGKFCMCDLPKMENAVIAPEGKTLSVACSGHTFQSGMQEEKITCTPEGFKKCIQTLINGIYSSGDSIFDGYEIQG-RKGKWPPKCKNEDCGSPPKISQGELTGAALARYTTGSSVEYRCHSYHLMEGTYCTRGTWLQLPKCLEPCRNVDLQWHGDMVEFKCMDGFELKGLCQNGHIL >XP_041446564.1 coagulation factor XIII B chain [Xenopus laevis] SVYKFCGCDLPVVENGKIAQEGKKLSLSCAGYSTQSGKQEEQITCKGVAFKKCIKSLNHGNYYSGDRVNEGYEIQG-KMGKWPPKCKSDFCQIPPPLTNGELIDLPSLSYKNSESVEYRCKSYHLMEGPNCTHGKWTELPTCLEPCRNLELKWHGDMIEFVCKDDLGLKGMCQRGNIR >XP_015826626.1 PREDICTED: complement factor H-like isoform X3 [Nothobranchius furzeri] TMFTIADCTLEQFLKSPNYDPGKQVRVPCKGFMGFY-----KLICSEGRIKSCGHDAAFGDYISDDQVQSGNRE---KEGTWAKKCASG-CGRPPSLTDGETVRFTKQQYENGDTVEYTCYNMYVLKGGTCNNGVWTGEMRCMKPCHNIEFSRHEDHLTFVCKHGTPMRKQCINGQMD >XP_030289713.1 complement factor H-related protein 1-like isoform X4 [Sparus aurata] RLFHLLLCDKPDIQ-----------------------------------------------LRSGQQLRPGHFLRG-AHGQWFPTCGLG-CNNPPTLADGDIKESLQDHYSHNERVEYICQNFYQMEGETCINGEWFGKMRCLRPCHNIAFKYHNDQIEFSCVRG-SMRSRCIDGVMH >XP_023820623.1 complement factor H-like isoform X1 [Oryzias latipes] --WILSSCARPELTHGFLV------------------------------------------FEENDKLTPGYRLTKAIKGSWIPTCEKGACDRPPKISNATILEASQEVFAEGSKLQYECKTGHNTEDGTCRAGWWMTPLPCSRVSQGQYTDFEGEIRSFNCGY--EKRARCINSEIF >tr|E2FHP6|E2FHP6_DANRE Complement factor H-like 2 protein OS=Danio rerio OX=7955 GN=cfhl2 PE=2 SV=1 ------DCLGTDINYENVEPDGKTVRVTCQGYTGMY-----RLRCEDGKKKRCSHEAANADYQDKEILNKPYDKIP-ENGKWDFVCT---CPPPPYIENGSHFSRNPDDKMP-TEVYYECQAYYVLSERRCENGRWRTPPKCLKPCHNMR---HGDYVDYYCQHRLYKKATCSDGKLE >XP_018891362.2 complement factor H-related protein 2 [Gorilla gorilla gorilla] -WLIVSFCDFPKINHGILYDTGEVFYYSCENFVSPSKSFWTRITCAEEGLRLCFFFVENGH----------------VERGWPPKCRAEKCGPPPPINNGDITSFPLSVYAPGASVEYQCQNLYQLEGNTCRNGQWSEPPKCLDPCYNIKLKWTGDIVEFVCKSEYSFRAMCQNGKLV >XP_009238002.1 complement factor H-related protein 2 isoform X1 [Pongo abelii] -WLMVSFCDFPKINHGILYDTGEVFYYSCENFVSPSKSFWTRITCTEEGLRLCFFFVENGHHLEGDTVQTGYRLQNNVERGWPPKCRAEKCGPPPPIDNGDITSFPLSVYAPGSSVEYQCQNLYQLEGNTCRNGQWSEPPKCLHPCYNIKLKWTGDIVEFVCKSAYSFRAVCQNGKLV >XP_034798898.1 complement factor H-related protein 2 [Pan paniscus] -WLMVS---------------------------------------------------------------------------------AEKCGPPPPIDNGDITSFPLSVYAPGSSVEYQCQNLYQLEGNTCRNGQWSEPPKCLDPCYNIKLKWTGDIVEFVCKSGYSFQAMCQNGKLV
PhyML tree of selected proteins (XP_010713972_1_complement_factor_H__Meleagris_gallopavo_:0.12340063,XP_025008854_1_complement_factor_H_isoform_X2__Gallus_gallus_:0.02699978,(PKK27813_1_coagulation_factor_XIII_B_chain__Columba_livia_:0.46181342,(((XP_040215769_1_coagulation_factor_XIII_B_chain_like__Rana_temporaria_:0.41488736,XP_041446564_1_coagulation_factor_XIII_B_chain__Xenopus_laevis_:0.40292228):0.86938932,(((tr_E2FHP6_E2FHP6_DANRE_Complement_factor_H_like_2_protein_OS_Danio_rerio_OX_7955_GN_cfhl2_PE_2_SV_1:1.89861797,(XP_023820623_1_complement_factor_H_like_isoform_X1__Oryzias_latipes_:2.45572452,(XP_015826626_1_PREDICTED__complement_factor_H_like_isoform_X3__Nothobranchius_furzeri_:0.91754977,XP_030289713_1_complement_factor_H_related_protein_1_like_isoform_X4__Sparus_aurata_:0.98273465):0.21852922):0.13266255):0.12991942,((XP_031560273_1_CUB_and_sushi_domain_containing_protein_3_like_isoform_X2__Actinia_tenebrosa_:2.35478832,XP_030839713_1_complement_receptor_type_2__Strongylocentrotus_purpuratus_:1.72711333):0.77357564,XP_038073060_1_low_density_lipoprotein_receptor_related_protein_2_like__Patiria_miniata_:2.90723428):0.00000001):0.33121455,(XP_008266942_1_PREDICTED__complement_factor_H_isoform_X10__Oryctolagus_cuniculus_:0.37221256,(((XP_038526744_1_complement_factor_H_related_protein_5__Canis_lupus_familiaris_:0.43647154,(XP_019677270_1_complement_factor_H_related_protein_2_like_isoform_X1__Felis_catus_:0.15069115,(XP_020937508_1_complement_factor_H_isoform_X7__Sus_scrofa_:0.1929166,((XP_002694314_1_complement_factor_H_related_protein_2__Bos_taurus_:0.01570032,(XP_005691103_1_PREDICTED__complement_factor_H_related_protein_2__Capra_hircus_:0.01684383,XP_004013976_1_complement_factor_H_related_protein_2__Ovis_aries_:0.01348496):0.05197852):0.02600209,((KAB0377273_1_hypothetical_protein_FD755_011717__Muntiacus_reevesi_:0.00595681,KAB0344555_1_hypothetical_protein_FD754_021481__Muntiacus_muntjak_:0.00000001):0.00387459,(XP_043341406_1_complement_factor_H_related_protein_2_like__Cervus_canadensis_:0.0132318,XP_020771892_1_complement_factor_H_related_protein_2_like__Odocoileus_virginianus_texanus_:0.06416681):0.02307517):0.03408483):0.15968026):0.08288336):0.11808202):0.07687362,(EDL39525_1_mCG9172__Mus_musculus_:0.11254215,NP_001037692_1_complement_factor_H_related_protein_1_precursor__Rattus_norvegicus_:0.17306993):0.22021633):0.04191094,(XP_024206509_1_complement_factor_H_related_protein_2_isoform_X1__Pan_troglodytes_:0.06583415,(XP_009238002_1_complement_factor_H_related_protein_2_isoform_X1__Pongo_abelii_:0.00781399,(XP_034798898_1_complement_factor_H_related_protein_2__Pan_paniscus_:0.01112207,(NP_005657_1_complement_factor_H_related_protein_2_isoform_1_precursor__Homo_sapiens_:0.01146866,XP_018891362_2_complement_factor_H_related_protein_2__Gorilla_gorilla_gorilla_:0.02593847):0.00000001):0.01577586):0.05660848):0.05019):0.14654878):0.27320571):0.1800057):0.12424753,(XP_014373981_1_complement_factor_H_like_isoform_X2__Alligator_sinensis_:0.37553923,XP_019343938_1_PREDICTED__complement_factor_H_related_protein_1__Alligator_mississippiensis_:0.44579921):0.13366317):0.21367933):0.30650063);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)