PB0033

DATABASE

Click here to access PB0033 phyletic profile

PBID	Uniprot	Name	Gene	Alternative	Organism	Uniprot Description
PB0033	P07355	Annexin A2	ANXA2	ANX2, ANX2L4, CAL1H, HEL-S-270, LIP2, LPC2, LPC2D, P36, PAP-IV	Homo_sapiens	Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9.

Domains

Gene Ontology

PF00191 (4_Annexin)

GO:0045121 (colocalizes with) membrane raft GO:0062023 (colocalizes with) collagen-containing extracellular matrix GO:0001786 (enables) phosphatidylserine binding GO:0002020 (enables) protease binding GO:0003723 (enables) RNA binding GO:0004859 (enables) phospholipase inhibitor activity GO:0004867 (enables) serine-type endopeptidase inhibitor activity GO:0005262 (enables) calcium channel activity GO:0005509 (enables) calcium ion binding GO:0005515 (enables) protein binding GO:0005544 (enables) calcium-dependent phospholipid binding GO:0005546 (enables) phosphatidylinositol-4,5-bisphosphate binding GO:0008092 (enables) cytoskeletal protein binding GO:0019834 (enables) phospholipase A2 inhibitor activity GO:0042802 (enables) identical protein binding GO:0044548 (enables) S100 protein binding GO:0046790 (enables) virion binding GO:0048306 (enables) calcium-dependent protein binding GO:0098641 (enables) cadherin binding involved in cell-cell adhesion GO:0001525 (involved in) angiogenesis GO:0001765 (involved in) membrane raft assembly GO:0001921 (involved in) positive regulation of receptor recycling GO:0006900 (involved in) vesicle budding from membrane GO:0010951 (involved in) negative regulation of endopeptidase activity GO:0031340 (involved in) positive regulation of vesicle fusion GO:0032804 (involved in) negative regulation of low-density lipoprotein particle receptor catabolic process GO:0036035 (involved in) osteoclast development GO:0043086 (involved in) negative regulation of catalytic activity GO:0044090 (involved in) positive regulation of vacuole organization GO:0070588 (involved in) calcium ion transmembrane transport GO:0098609 (involved in) cell-cell adhesion GO:1905581 (involved in) positive regulation of low-density lipoprotein particle clearance GO:1905597 (involved in) positive regulation of low-density lipoprotein particle receptor binding GO:1905599 (involved in) positive regulation of low-density lipoprotein receptor activity GO:1905602 (involved in) positive regulation of receptor-mediated endocytosis involved in cholesterol transport GO:0005576 (located in) extracellular region GO:0005604 (located in) basement membrane GO:0005615 (located in) extracellular space GO:0005634 (located in) nucleus GO:0005737 (located in) cytoplasm GO:0005765 (located in) lysosomal membrane GO:0005768 (located in) endosome GO:0005811 (located in) lipid droplet GO:0005886 (located in) plasma membrane GO:0005912 (located in) adherens junction GO:0009986 (located in) cell surface GO:0016020 (located in) membrane GO:0016323 (located in) basolateral plasma membrane GO:0030496 (located in) midbody GO:0031902 (located in) late endosome membrane GO:0031982 (located in) vesicle GO:0035578 (located in) azurophil granule lumen GO:0042470 (located in) melanosome GO:0070062 (located in) extracellular exosome GO:1990665 (part of) AnxA2-p11 complex GO:1990667 (part of) PCSK9-AnxA2 complex

External Links	Description
Intact	Open source database system and analysis tools for molecular interaction data.
Protein Atlas	An open access resource for human proteins
InterPro (new pfam)	InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites.

Seed proteins (Human and Zebrafish) >sp|P07355|ANXA2_HUMAN Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2 MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIL TNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRA EDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDM LESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDM LKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >tr|A8E5G1|A8E5G1_DANRE Annexin OS=Danio rerio OX=7955 GN=anxa2b PE=1 SV=1 MALVSEYLSKLTLSYGGEREPKCPTVVAAYDFNPEVDAAKIETAIKTKGVDEQTIIDILT RRSYLQRNDIAFEYEKRAKKDLVSALKGALSGSLEHLILGLMKSTPQYDAFELKASMKGL GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLALAQGKREE QSSVVDYEKIDNDARTLYETGVKRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIK ESIRMEVKGDLEKSFLTLVECLENKHLYFASRLNDAMKGKSVKDKIITRIIVSRCEVDLM KVRIEFKRNFGRSLHQTISEHTKGDYQRALLNLVGGDD
Selected proteins from model organisms >NP_004030.1 annexin A2 isoform 2 [Homo sapiens] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >KAF4020192.1 hypothetical protein G4228_012105 [Cervus hanglu yarkandensis] MAMVSEFLKQAWFIENEEQEYIKTVKGYKGGPGSAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQI KAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNREIREINRVYREEL KRDLAKDIASDTSGDYEKALLSLAKGDRSEELAVNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKY SKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYG ISLCQAILDETKGDYEKILVALCGGN >XP_030835585.1 annexin-B12 isoform X2 [Strongylocentrotus purpuratus] MSYPYPTGGAPYPQQGGGYPPQAGGYPQPGGYPQAPAPAGYPPQGGYPPAAGGYPPAAGGGYPPPAGAGGYPPAPAPAPG YPPAPGVGYPPQQPSYPPAPQPGYPPQQPGYGAPPQAGMPMPSDYGSMHGGGLPYGAQPNMGFAGAAMAATAFRPPPVQP APVIGGPGMPQPQAAYAGAASIPAQAPPAQAPPQQRPAPVAAPVVAKSSTPTQQMANMSLSAGAIVRGTGTVKPKANFNG QKEAEILRKAMKGMGCDETAVISIMTTCSAVQRRQIALDFKTMYGKDLEKNLKGELKGKLETIVLNLLYLPAEFDAHMLR KAMKGLGTDEATLVEVLCTRTNDEVQAIKVAYKKEFSRDLEKDVISETSGHFKRLLVSMLQGSRSQDQRVDVEKAKADAK ALVTAGEARWGTDESAFNAVLASRSYPQLRAIFNEYSKLVKYTMEQSIKREMSGDLEKGMLTIVQCVRNTPAYFAEKLYK SMKGLGTDDDTLMRVIISRVEIDMVEIKQEFQRAYNQSLGRFIKGDTSGDYKKILLALIGGE >CAE1230049.1 ANXA7_11 [Sepia pharaonis] MVVCHYHPRTPCGPFLFLTVDFMHGDSQVFMPDESILSKSANLFSAAAKVVTAAYIAFHLLGNMSYPYYGAGQNAPQNYP PNMGQQPNPSMGYPNFTGYDSTPNMQYSAQPSAGPGVIGFNIGMTNQGGYPNTQQGAYPPPAQQGAYPPPPQQGAYPPPA QQGSYPPPAQQGMYPPPQQQGAYPPTQRGMYPPPPQPGAYPPPPQQGSYPPVPGSSSPRPQHTAYPPQQQTVNPSQQEFY PASHQQQKGYFPSEQQTSHPIPSSRQNKPLKEEGTLKPYPGFNAETDAQILRKAMKGFGTDEKAIIDVLGSRSNEQRQDI VRMFKTIFGKDLIKELKSELSGNFETVVLGLLYTPSMYDATELKKAMQGLGTNEDVLIEIMCSRSNKEIMEISDCFKKIT GKSLENWLKSETSGHFCRLLVSLSTAGRSENQNVDLQSAEQDAKKLYEAGEKQWGTNESQFNAILASRSLPQLKAVFDAY KHLYNRDIEQVIASEMSGDLLSGMLSVVKVVKSKPCYFAERLYTSMKGAGTNDSTLIRVIISRCEIDMKQIKQEFQKMYG KTLDAMVKGDCSGDYCRILLRLLGNESY >XP_038060971.1 annexin A5-like [Patiria miniata] MSYGGYPPAPGGYPPAQGGYPPAPGGGGYPPAPGGGGYPPAAPGGGGYPGGGGYPSVPGGGGYPPAPAPGAGGYPPAPGG YPPAPGGGGYPPAPGGGGYPPAPAPGGYPPAMPQPGYPPAPQPAGYPTGAPVSMPSADYGASVGSAGLPYNPNPTSSMGF AGAAYAATAFRPPSASAFRQPAAPAPGGPPMPTPQYTPTPQYNPPPAQRAPAPQSAPGAQAPIVPTQQLASMSMAPKAVK RGTGTVKEKSNFDGHKEAEILRKAMKGIGTDEKAIIGVVTACSNAQRQRLLIDYKTMYGKDLVKNLKSELKSKLEEVVLD LMMTPALFDAHQLRKAMKGLGTDEAVLIEILCTRTNQEIVTIKEAYKKEFSRNLEKDVISETSGHFQRLLVSMTQGARRE DPTVDQAKAKADAKALWDAGEKKWGTDESQFNVILASRSFPQLRATFEEYSKLGKYSIEQSIKREMSGDLEKGMLTIVDC VRNTPKYFSDKLYKSMKGLGTDDDTLIRIIVSRCEIDMVEIKQEFHRDHKQTLGKFIAGDTSGDYKKILLELVGGES >XP_031556011.1 annexin-B12-like isoform X2 [Actinia tenebrosa] MSYGPPWNYGMPQPGAPPFPMQQGGAPPPLGFDHVLSSPSGPAGVGGMPMPMAQPSMPYQAMPTQSGPGMPLPGAMSYPT PGYGPAPPASPAPMGHYPNQNLTFGTTYYHEETSYSTQSTVASAPPLQTMASSVLCSSKPSSRGRPSVTAYSPFDGKKDA EVLRKAMKGLGCDNKAITYLLCSRTNAQRQRISIEYKTIYGRDLMKDLKSELGGHFEDTVIALMTPPEEYDATLIRKALK GLGTNEEILIEILSTRTNNELVAIKNAYQRLFERDMEKDIAGDTSGHFKKFLISLAQAYREETDQVDIHKARASAEALYK AGEGRWGTDEAKFNSVLASKSFPQLRAVFDEYSKICKYDIEESIRREMSGDLKDGMVSIVQVVRNAPGFFAQKLYKSMKG LGTDDKALIRVVVTRSEIDILDIKDEFAKQYGQSLAQFIADDTKGNYKRILLQLIGESA >XP_039270557.1 annexin A4-like isoform X2 [Styela clava] MSYGYPYQQGGAPPPGGGYPPQPQGYPPQGGYPPQQGGYPPQGGYPPAPGGPAYPPGPGGPGYPPAPGGAPGYPPAPGYP PAAGGYPQPGAPGAYPPPGQSSGLGFDALAGPPQPAAQSYGQPPGGYGYGAPPAPGGYPPAAGYPPQAQQAYGAQPAAGY HPPAGYGAPGPSHKMSNPQQLAAGMAAMTIATHGTVKAYPSFNAEEDAKILRKAMKGIGTDEKSIINVIGHRNNKQRQDI IIAYKQAYGKDLIKDLKSELSGNFESLVKAMFMKPRHYDVYCLERSMSGIGTDESALIEIFTSRSNAEIKEIKEIFKKER KKDLEKALKSETSGHFSRLLVSLCNASRNETTSVDQGKARADAQALYQAGEKKWGTDEATFNMIMCSRSIPQLRATFIEY HKIANRDISKSIEGEFSGDIEEGLKAVVETARSAPAYFAKRLYKSMSGAGTDDHTLIRIVVSRSEIDMVEIKQEFQRTYS KTLGSFIQGDTSGDYKNLLTTLVGP >XP_026296548.1 annexin B9 [Apis mellifera] MSQQQYYPFKCTPTVYPAEPFDANADAALLRKAMKGFGTDEKTIIDVLTRRGIVQRLEVAEAYKTLYGKDLISDLKSELT GKLEDVIIALMTPLPHYYAKELHDAVSGLGTDEEAIVEILCTLSNYGIRTIAAFYENLYGKSLESDLKGDTSGHFKRLLV SLVQANRDENQGIDQTQAIADAQALYEAGEKQWGTDESQFNAILVTRSYQQLRQTFIEYEKISGHDIEVAIKKEFSGNLE KGLLGIVKCVKSKVGFFAERLYASMHGIGTKDRTLIRIIVSRSEIDLGDIKKAFEERYGKSLESWIAGDTSGDYKKALLS LVST >NP_476615.1 annexin B10, isoform A [Drosophila melanogaster] MEYKPVPTVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDELGGKFEDV IVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPLAEQMCSETSGFFRRLLTLIVTGV RDGLDTPVDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHASFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMA IVECVQSPAAFFANRLYKAMNGAGTDDATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVAETSGDYKRALTALLGSA >NP_001022756.1 Annexin [Caenorhabditis elegans] MNSGGGYPNQQPSYGGYGQPPQQPGYGNGSYDPYGQPQQQPYPGGGGQPPYPGSNSNQGGGGYPGQGGAPYPGGSGGYPQ APQYGFSGGQGSAPQPNQGGYPPQQQQYPPQQGYQQGGQQQGGGGFFPNQGYGQPVMIGTPSVFPVQGFNSNADAEVLRK AMKGLGCNNSKVISILCQRTNWQRQEISKAFKVMYGKDLIKELKGELHGDFEDLILALMDAPAIYDAKQLHRAMEGLGTK ESVLIEIMTSRTNAQIQQVRDAYKMLFKKDLERDLIGETSGHFKRLLVSLCAGGRDESSQTDGLRANQDARRLLQAGEKR LGTDESTFNAILASQNFSQLRLVFEEYQKASNHSIEKAIEFEFSGDIRDGLLAVIAVIRNRPAYFAKLLHDSMKGLGTRD NDLIRLCVTRAEYDMGDIRNMFQSLYRTSLENMIKGDCSGAYKEGLIALVNGNRG >NP_031611.1 annexin A2 [Mus musculus] MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQD IAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_063970.1 annexin A2 [Rattus norvegicus] MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD >NP_777141.1 annexin A2 [Bos taurus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_990682.1 annexin A2 [Gallus gallus] MSTVHEILSKLSLEGDHSLPPSAYATVKAYSNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQD IAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQEL NEINRVYREMYKTELEKDIISDTSGDFRKLMVALAKGKRCEDTSVIDYELIDQDARELYDAGVKRKGTDV PKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKG KGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQRALLNLCGGED >NP_001002961.1 annexin A2 [Canis lupus familiaris] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001005726.1 annexin A2 [Sus scrofa] MSTVHEILCKLSLEGDHSTPASAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIXIMVSRSEVDMLKIRSEFKRKYGKSLYNYIQQDTKGDYQKALLYLCGGDD >XP_001155637.2 annexin A2 [Pan troglodytes] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001087257.1 annexin A2 [Ovis aries] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001126816.1 annexin A2 [Pongo abelii] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_017203467.1 PREDICTED: annexin A2 [Oryctolagus cuniculus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYGNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELPAALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYSYIQQDTKGDYQKALLYLCGGDD >XP_031411076.1 annexin A2 [Meleagris gallopavo] MKLNLARDVKNNKKVFYRYIDQKRWTKECVPPLLNENKELASTDTEKAEVLSLNMSQQGVLAAWKANGVL GSIRRGVGSRDRGHSLPPSAYATVKAYSNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAF AYQRRTKKELSAALKSALSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEI NRVYREMYKTELEKDIISDTSGDFRKLMVALAKGKRCEDTSVIDYELIDQDARELYDAGVKRKGTDVPKW INIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFINLVQCIQNKQLYFADRLYDSMKGKGT RDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQRALLNLCGGED >XP_003827964.1 annexin A2 [Pan paniscus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_003987117.1 annexin A2 [Felis catus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELTSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYCIQQDTKGDYQKALLYLCGGDD >XP_004056331.1 annexin A2 [Gorilla gorilla gorilla] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_017909777.1 PREDICTED: annexin A2 [Capra hircus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >KAB0341462.1 hypothetical protein FD754_018388 [Muntiacus muntjak] MSCMAESLCCVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYD AGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001081284.1 annexin A2-A [Xenopus laevis] MALIHEILGKLSLEGNQSCARQSALGTVKASTNFDAEKDAAAIETAIKTKGVDELTIINILTNRSNDQRQDIAFAYHRRT KKDLASALKGALSGNLETVMLGLIKTRPQYDASELKASMKGLGTDEDTLIEIICSRTNKELLDIQNAYRELYKTELEKDI VSDTSGDFRKLMVALAKGKRQEEGSVVDYEKIDQDARELYEAGVKRKGTDVGKWITIMTERSTPHLQKVFERYKSYSPYD MEESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYESMKGRGTKDKILIRTMVSRSELDMLKIRKEFKKKYGKSLHYFI GQDTKGDYQRALFNLCGGDD >OWK09220.1 ANXA2 [Cervus elaphus hippelaphus] MKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARD LYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDS MKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_015808682.1 PREDICTED: annexin A2-B-like [Nothobranchius furzeri] MALVSEFLGQLTLSYSGEEEPKYPTVVPVRDFDPVRDAARIDTAIKTKGVDEQTVIDILTRRSAQQRQEIAFEFERFSKK DLTSALKGALSGSLETLVLGLMKTTTQYDASELKASMKGLGTDEETLIELVCSRNDDELTEIKKVYREMFKKELDKDIAG DTSGDFAKLLLALVQTKRDEPSNVVDYQKIDDDARSLYEAGVKRKGTDVVTWISIMSQRSIPHLRKVFERYKSYSPYDMK ESIRKEVKGDLEKSFLTLVECFENKQLYFANRLYEAMKSKGAKEKVVTRIMVSRCEVDLMRIRTEFKRQYKKSLYQTIAE HTKGDYQKALLSLCGGDD >XP_030271470.1 annexin A2-like [Sparus aurata] MALVSEFLGQLTLSYGGEEEPAFPTVVPVHDFDPNKDAARIETAIKTKGVDEQTIIDILTRRSYEQRRQIAFEYERLAKK DLVTALKAALSGSLEALMLGLMKSTAQYDASELKASIKGLGTDEEALIEIVCSRNNEELVEIKRVYKEMFKKELEKDIAG DTSGDFAKLLLALFQTKRDEPSNVVDYEKIDEDARCLYEAGVKRKGTDVGTWISIMAKRSVPHLQKVFERYKSYSPYDMK ESIRKEVKGDLEKSFLTLVECFENRQLYFANRLSEAMKSKGAKEKVVTRIIVSRCEVDLMKIRTEFKRQHKRSLYQTIAE HTKGDYQKALLSLCGGDD >XP_023809545.1 annexin A2 [Oryzias latipes] MAMVSEFLGQLTLAYGGEPEPRCPTVVPVKDFDPTHDAARIDAAIKTKGVDEQTIIDILTRRSCQQRREIAFEYERMAKK DLSSALKGALSGSLEALMLGLMKSTAQFDASELRASMKGLGTDEEVLIEMLCSRSEEELMEIKKEYREMFKKEVEKDIAG DTSGNFAKLLLALVQTRRDEPSNVVDYQKIDEDARSLYEAGVKRKGTDVTTWISIMSQRSVPHLQKVFERYKSYSPYDIK ESIKKEVKGDLEKSFLTLVECFENRQLYFANRLNDAMKSKGAKEKVLTRIMVSRCEVDLMKIRTEFKKHHRRSLYQTIAE HTKGDYQKALLSLCGGDD >KAB0368712.1 hypothetical protein FD755_019746 [Muntiacus reevesi] MAMVSEFLKQAWFIENEEQEYIKTVKAYKGGPGSAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQI KAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNKEIREINRVYREEL KRDLAKDIASDTSGDYEKALLSLAKGDRSEELAVNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKY SKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNQPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYG ISLCQAILDETKGDYEKILVALCGGN >XP_043343301.1 annexin A1 [Cervus canadensis] MAMVSEFLKQAWFIENEEQEYIKTVKGYKGGPGSAVSPYPTFNPSSDVEALHKAITVRGVDEATIIEILTKRNNAQRQQI KAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNGEIREINRVYREEL KRDLAKDIASDTSGDYEKALLSLAKGDRSEELAVNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKY SKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYG ISLCQAILDETKGDYEKILVALCGGN >tr|A8E5G1|A8E5G1_DANRE Annexin OS=Danio rerio OX=7955 GN=anxa2b PE=1 SV=1 MALVSEYLSKLTLSYGGEREPKCPTVVAAYDFNPEVDAAKIETAIKTKGVDEQTIIDILT RRSYLQRNDIAFEYEKRAKKDLVSALKGALSGSLEHLILGLMKSTPQYDAFELKASMKGL GTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLALAQGKREE QSSVVDYEKIDNDARTLYETGVKRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIK ESIRMEVKGDLEKSFLTLVECLENKHLYFASRLNDAMKGKSVKDKIITRIIVSRCEVDLM KVRIEFKRNFGRSLHQTISEHTKGDYQRALLNLVGGDD >XP_025055252.1 annexin A2 [Alligator sinensis] MSTVHEILTKLSLEGDHSIPPSAYATVKAYSNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQEL AEINRVYKEMYKIELEKDIVSDTSGDFRKLMVALAKGRRSEDSSMVDYELIDQDARDLYDAGVKRKGTDV PKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKG >XP_006259442.1 PREDICTED: annexin A2 [Alligator mississippiensis] MSTVHEILTKLSLEGDHSLPPSAYATVKAYSNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQEL AEINRVYKEMYKIELEKDIVSDTSGDFRKLMVALAKGRRSEDSSMVDYELIDQDARDLYDAGVKRKGTDV PKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKGDYQKALLNLCGGED >XP_020749772.1 annexin A2 [Odocoileus virginianus texanus] MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQD IAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQEL QEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDV PKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKG KGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_040198909.1 annexin A2 [Rana temporaria] MATIHEILGKLKLEGNQSSTTQHALGTVRPSTNFDAEKDAAALETAIKTKGVDELTIISILTNRTNDQRQ DIAFAYQRRTKKDLPSALKGALSGHLETLILGLMKTRPQYDASELKSAMKGLGTDEDTLIEIICSRDNDE LHAIQAAYKELYKTELEKDIVSDTSGDFRKLMVALAKGKRQEDGSVVDYEKIDQDARELYEAGVKRKGTD VSKWITIMTERSICHLQKVFDRYKSYSPYDMQESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYESMK GKGTKDKILIRNMVSRCEVDLLKIKAEFKRKYNKSLSYFISQDTKGDYQRALLNLCAGDD
Mafft alignment of selected proteins >NP_004030.1 annexin A2 isoform 2 [Homo sapiens] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >KAF4020192.1 hypothetical protein G4228_012105 [Cervus hanglu yarkandensis] M----------------------------------------------------AMVSE-- --------------------------------------------------FLKQA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------WFIENEEQEY---IKTVKGYKGGPGSAVSPY PTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKA LVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNREIREINRVYREE LKRDLAKDIASDTSGDYEKALLSLAKGDRSE-ELA-VNDDLADSDARALYEAGERRKGTD VNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMF FAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEK ILVALCGGN-- >XP_030835585.1 annexin-B12 isoform X2 [Strongylocentrotus purpuratus] M----------------------------------------------------SY----- ---------------------------------PYPTGGAPYPQQ--GGGYPPQA----- -----GGYPQPGGYPQAPAPAGYPP-----QGGYPPAAGGYPPA-AGGGYPPPAGAGGYP PAPAPAPGYPPAPGVG-YPPQQPS-YPPAPQPGYPPQQPGYGAPPQAGMPMP-SDYG-SM HGGGLPYGAQP--NMGFAGAAMAATAFRPP-------PVQPAPVIGGPGMPQPQAAYAGA ASIPAQAPPAQAPP-QQRPAPVAAPVVAKSSTPTQQMAN---MSLSAGAIVRGTGTVKPK ANFNGQKEAEILRKAMKGMGCDETAVISIMTTCSAVQRRQIALDFKTMYGKDLEKNLKGE LKGKLETIVLNLLYLPAEFDAHMLRKAMKGLGTDEATLVEVLCTRTNDEVQAIKVAYKKE FSRDLEKDVISETSGHFKRLLVSMLQGSRSQ-DQR-VDVEKAKADAKALVTAGEARWGTD ESAFNAVLASRSYPQLRAIFNEYSKLVKYTMEQSIKREMSGDLEKGMLTIVQCVRNTPAY FAEKLYKSMKGLGTDDDTLMRVIISRVEIDMVEIKQEFQRAYNQSLGRFIKGDTSGDYKK ILLALIGGE-- >CAE1230049.1 ANXA7_11 [Sepia pharaonis] MVVCHYHPRTPCGPFLFLTVDFMHGDSQVFMPDESILSKSANLFSAAAKVVTAAYIAFHL LGNMSYPYYGAGQNAPQNYPPNMGQQPNPSMGYPNFTGYDSTP----NMQYSAQPSAGPG VIGFNIGMTNQGGYPN-TQQGAYPP---------PAQQGAYPPPPQQGAYPPPAQQGSYP P-PAQQGMYPPPQQQGAYPPTQRGMYPPPPQPG--------AYPPP-------PQQG--- ---------------SYP----------------------PVP---GSSSPRPQH---TA YPPQQQTVN---PS-QQEFYPASHQQ-QKGYFPSEQQTSHPIPSSRQNKPLKEEGTLKPY PGFNAETDAQILRKAMKGFGTDEKAIIDVLGSRSNEQRQDIVRMFKTIFGKDLIKELKSE LSGNFETVVLGLLYTPSMYDATELKKAMQGLGTNEDVLIEIMCSRSNKEIMEISDCFKKI TGKSLENWLKSETSGHFCRLLVSLSTAGRSE-NQN-VDLQSAEQDAKKLYEAGEKQWGTN ESQFNAILASRSLPQLKAVFDAYKHLYNRDIEQVIASEMSGDLLSGMLSVVKVVKSKPCY FAERLYTSMKGAGTNDSTLIRVIISRCEIDMKQIKQEFQKMYGKTLDAMVKGDCSGDYCR ILLRLLGNESY >XP_038060971.1 annexin A5-like [Patiria miniata] M----------------------------------------------------SYGGY-- ------------PPAPGGYPPAQG-------GYPPAPGGGGYPPAPGGGGYPPAAPGG-- -----GGYPGGGGYPSVPGGGGYPPAPAPGAGGYPPAPGGYPPAPGGGGYPPAPGGGGYP PAPAPG-GYPPA-------MPQPG-YPPAPQPA--------GYPTGAPVSMPSADYGASV GSAGLPYNPNPTSSMGFAGAAYAATAFRPPSASAFRQPAAPAP--GGPPMPTPQ-----Y TPTPQYNPP---PA-QRAPAPQSAPGAQAPIVPTQQLAS---MSMAPKAVKRGTGTVKEK SNFDGHKEAEILRKAMKGIGTDEKAIIGVVTACSNAQRQRLLIDYKTMYGKDLVKNLKSE LKSKLEEVVLDLMMTPALFDAHQLRKAMKGLGTDEAVLIEILCTRTNQEIVTIKEAYKKE FSRNLEKDVISETSGHFQRLLVSMTQGARRE-DPT-VDQAKAKADAKALWDAGEKKWGTD ESQFNVILASRSFPQLRATFEEYSKLGKYSIEQSIKREMSGDLEKGMLTIVDCVRNTPKY FSDKLYKSMKGLGTDDDTLIRIIVSRCEIDMVEIKQEFHRDHKQTLGKFIAGDTSGDYKK ILLELVGGES- >XP_031556011.1 annexin-B12-like isoform X2 [Actinia tenebrosa] M----------------------------------------------------SY----- -------------------------------GPPWNYG-------------MPQP----- ------GAPP---FP--MQQGGAPP------------PLGFDHVLSSPSGPAGVGGM--- PMPMAQPSMPYQAM-----PTQSGPGMPLPGAM--------SYPTP-------------- ---------------GYG----------------------PAP----PASPAPM----GH YPNQNLTFG---TTYYHEETSYSTQSTVASAPPLQTMASS--VLCSSKPSSRGRPSVTAY SPFDGKKDAEVLRKAMKGLGCDNKAITYLLCSRTNAQRQRISIEYKTIYGRDLMKDLKSE LGGHFEDTVIALMTPPEEYDATLIRKALKGLGTNEEILIEILSTRTNNELVAIKNAYQRL FERDMEKDIAGDTSGHFKKFLISLAQAYREE-TDQ-VDIHKARASAEALYKAGEGRWGTD EAKFNSVLASKSFPQLRAVFDEYSKICKYDIEESIRREMSGDLKDGMVSIVQVVRNAPGF FAQKLYKSMKGLGTDDKALIRVVVTRSEIDILDIKDEFAKQYGQSLAQFIADDTKGNYKR ILLQLIGESA- >XP_039270557.1 annexin A4-like isoform X2 [Styela clava] M----------------------------------------------------SY----- -------------------------------GYPYQQGGAPPP----GGGYPPQP----- -----QGYPPQGGYP--PQQGGYPP------------QGGYPPAPGGPAYPPGPGGPGYP PAPGGAPGYPPAPG---YPPAAGG-YPQPGAPG--------AYPPPGQS----SGLGFDA ----LAGPPQPA-AQSYG---------QPPGGYGYGAP--PAP---GGYPPAA-----GY PPQAQQAYGAQPAAGYHPPAGYGAPGPSHKMSNPQQLAA-----GMAAMTIATHGTVKAY PSFNAEEDAKILRKAMKGIGTDEKSIINVIGHRNNKQRQDIIIAYKQAYGKDLIKDLKSE LSGNFESLVKAMFMKPRHYDVYCLERSMSGIGTDESALIEIFTSRSNAEIKEIKEIFKKE RKKDLEKALKSETSGHFSRLLVSLCNASRNE-TTS-VDQGKARADAQALYQAGEKKWGTD EATFNMIMCSRSIPQLRATFIEYHKIANRDISKSIEGEFSGDIEEGLKAVVETARSAPAY FAKRLYKSMSGAGTDDHTLIRIVVSRSEIDMVEIKQEFQRTYSKTLGSFIQGDTSGDYKN LLTTLVGP--- >XP_026296548.1 annexin B9 [Apis mellifera] M----------------------------------------------------------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------------------------------SQQQYYPFKCTPTVYPA EPFDANADAALLRKAMKGFGTDEKTIIDVLTRRGIVQRLEVAEAYKTLYGKDLISDLKSE LTGKLEDVIIALMTPLPHYYAKELHDAVSGLGTDEEAIVEILCTLSNYGIRTIAAFYENL YGKSLESDLKGDTSGHFKRLLVSLVQANRDE-NQG-IDQTQAIADAQALYEAGEKQWGTD ESQFNAILVTRSYQQLRQTFIEYEKISGHDIEVAIKKEFSGNLEKGLLGIVKCVKSKVGF FAERLYASMHGIGTKDRTLIRIIVSRSEIDLGDIKKAFEERYGKSLESWIAGDTSGDYKK ALLSLVST--- >NP_476615.1 annexin B10, isoform A [Drosophila melanogaster] M----------------------------------------------------EY----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------------------------------KPVPTVKDA APFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDE LGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEER YQRPLAEQMCSETSGFFRRLLTLIVTGVRDGLDTP-VDVGQAKEQAAQLYSAGEAKLGTD EEVFNRIMSHASFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAF FANRLYKAMNGAGTDDATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVAETSGDYKR ALTALLGSA-- >NP_001022756.1 Annexin [Caenorhabditis elegans] M----------------------------------------------------NS----- -----------------------------------------------GGGYPNQQ----- --------PSYGGYGQPPQQPGY-------------GNGSYDPY-GQPQQQPYPGGGGQP PYPGSN----SNQGGGGY-PGQGG-APYPGGSG--------GYPQA-------PQYGFSG ---------------------------------------------GQGSAPQPNQ---GG YPPQQQQY----PP-QQGYQQGGQQQGGGGFFPNQ---------GYGQPVMIGTPSVFPV QGFNSNADAEVLRKAMKGLGCNNSKVISILCQRTNWQRQEISKAFKVMYGKDLIKELKGE LHGDFEDLILALMDAPAIYDAKQLHRAMEGLGTKESVLIEIMTSRTNAQIQQVRDAYKML FKKDLERDLIGETSGHFKRLLVSLCAGGRDE-SSQ-TDGLRANQDARRLLQAGEKRLGTD ESTFNAILASQNFSQLRLVFEEYQKASNHSIEKAIEFEFSGDIRDGLLAVIAVIRNRPAY FAKLLHDSMKGLGTRDNDLIRLCVTRAEYDMGDIRNMFQSLYRTSLENMIKGDCSGAYKE GLIALVNGNRG >NP_031611.1 annexin A2 [Mus musculus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKPY TNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARELYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_063970.1 annexin A2 [Rattus norvegicus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKPY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSA LSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGEFRKLLVALAKGKRAE-DGSVIDYELIDQDARELYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQK ALLYLCGGDD- >NP_777141.1 annexin A2 [Bos taurus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_990682.1 annexin A2 [Gallus gallus] M----------------------------------------------------STVHE-- --------------------------------------------------ILSKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSLPPSAYATVKAY SNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAFAYQRRTKKELSAALKSA LSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEINRVYREM YKTELEKDIISDTSGDFRKLMVALAKGKRCE-DTSVIDYELIDQDARELYDAGVKRKGTD VPKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKQLY FADRLYDSMKGKGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQR ALLNLCGGED- >NP_001002961.1 annexin A2 [Canis lupus familiaris] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_001005726.1 annexin A2 [Sus scrofa] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPASAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIXIMVSRSEVDMLKIRSEFKRKYGKSLYNYIQQDTKGDYQK ALLYLCGGDD- >XP_001155637.2 annexin A2 [Pan troglodytes] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_001087257.1 annexin A2 [Ovis aries] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_001126816.1 annexin A2 [Pongo abelii] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >XP_017203467.1 PREDICTED: annexin A2 [Oryctolagus cuniculus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY GNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPAALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYSYIQQDTKGDYQK ALLYLCGGDD- >XP_031411076.1 annexin A2 [Meleagris gallopavo] MKLNLARDVKNNKKVFYRYIDQKRWTKECVPP---LLNENKEL---------ASTDTEKA ----------------------------EVLSLNMSQQGVLAAWK--ANGVLGSI----- ------------------------------------------------------------ ---------------------RRG------------------------------------ ------------------------------------------------------------ ---------------------------------VGSRDR------GHSLPPSAYATVKAY SNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAFAYQRRTKKELSAALKSA LSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEINRVYREM YKTELEKDIISDTSGDFRKLMVALAKGKRCE-DTSVIDYELIDQDARELYDAGVKRKGTD VPKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFINLVQCIQNKQLY FADRLYDSMKGKGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQR ALLNLCGGED- >XP_003827964.1 annexin A2 [Pan paniscus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >XP_003987117.1 annexin A2 [Felis catus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELTSALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYCIQQDTKGDYQK ALLYLCGGDD- >XP_004056331.1 annexin A2 [Gorilla gorilla gorilla] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIISDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >XP_017909777.1 PREDICTED: annexin A2 [Capra hircus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >KAB0341462.1 hypothetical protein FD754_018388 [Muntiacus muntjak] M----------------------------------------------------SCMAE-- --------------------------------------------------SLC------- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -------------------CVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >NP_001081284.1 annexin A2-A [Xenopus laevis] M----------------------------------------------------ALIHE-- --------------------------------------------------ILGKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG-----NQSCARQSALGTVKAS TNFDAEKDAAAIETAIKTKGVDELTIINILTNRSNDQRQDIAFAYHRRTKKDLASALKGA LSGNLETVMLGLIKTRPQYDASELKASMKGLGTDEDTLIEIICSRTNKELLDIQNAYREL YKTELEKDIVSDTSGDFRKLMVALAKGKRQE-EGSVVDYEKIDQDARELYEAGVKRKGTD VGKWITIMTERSTPHLQKVFERYKSYSPYDMEESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYESMKGRGTKDKILIRTMVSRSELDMLKIRKEFKKKYGKSLHYFIGQDTKGDYQR ALFNLCGGDD- >OWK09220.1 ANXA2 [Cervus elaphus hippelaphus] ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ---------------------------MKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >XP_015808682.1 PREDICTED: annexin A2-B-like [Nothobranchius furzeri] M----------------------------------------------------ALVSE-- --------------------------------------------------FLGQL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TLSY-------SGEEEPKYPTVVPV RDFDPVRDAARIDTAIKTKGVDEQTVIDILTRRSAQQRQEIAFEFERFSKKDLTSALKGA LSGSLETLVLGLMKTTTQYDASELKASMKGLGTDEETLIELVCSRNDDELTEIKKVYREM FKKELDKDIAGDTSGDFAKLLLALVQTKRDE-PSNVVDYQKIDDDARSLYEAGVKRKGTD VVTWISIMSQRSIPHLRKVFERYKSYSPYDMKESIRKEVKGDLEKSFLTLVECFENKQLY FANRLYEAMKSKGAKEKVVTRIMVSRCEVDLMRIRTEFKRQYKKSLYQTIAEHTKGDYQK ALLSLCGGDD- >XP_030271470.1 annexin A2-like [Sparus aurata] M----------------------------------------------------ALVSE-- --------------------------------------------------FLGQL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TLSY-------GGEEEPAFPTVVPV HDFDPNKDAARIETAIKTKGVDEQTIIDILTRRSYEQRRQIAFEYERLAKKDLVTALKAA LSGSLEALMLGLMKSTAQYDASELKASIKGLGTDEEALIEIVCSRNNEELVEIKRVYKEM FKKELEKDIAGDTSGDFAKLLLALFQTKRDE-PSNVVDYEKIDEDARCLYEAGVKRKGTD VGTWISIMAKRSVPHLQKVFERYKSYSPYDMKESIRKEVKGDLEKSFLTLVECFENRQLY FANRLSEAMKSKGAKEKVVTRIIVSRCEVDLMKIRTEFKRQHKRSLYQTIAEHTKGDYQK ALLSLCGGDD- >XP_023809545.1 annexin A2 [Oryzias latipes] M----------------------------------------------------AMVSE-- --------------------------------------------------FLGQL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TLAY-------GGEPEPRCPTVVPV KDFDPTHDAARIDAAIKTKGVDEQTIIDILTRRSCQQRREIAFEYERMAKKDLSSALKGA LSGSLEALMLGLMKSTAQFDASELRASMKGLGTDEEVLIEMLCSRSEEELMEIKKEYREM FKKEVEKDIAGDTSGNFAKLLLALVQTRRDE-PSNVVDYQKIDEDARSLYEAGVKRKGTD VTTWISIMSQRSVPHLQKVFERYKSYSPYDIKESIKKEVKGDLEKSFLTLVECFENRQLY FANRLNDAMKSKGAKEKVLTRIMVSRCEVDLMKIRTEFKKHHRRSLYQTIAEHTKGDYQK ALLSLCGGDD- >KAB0368712.1 hypothetical protein FD755_019746 [Muntiacus reevesi] M----------------------------------------------------AMVSE-- --------------------------------------------------FLKQA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------WFIENEEQEY---IKTVKAYKGGPGSAVSPY PTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKA LVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNKEIREINRVYREE LKRDLAKDIASDTSGDYEKALLSLAKGDRSE-ELA-VNDDLADSDARALYEAGERRKGTD VNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNQPMF FAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEK ILVALCGGN-- >XP_043343301.1 annexin A1 [Cervus canadensis] M----------------------------------------------------AMVSE-- --------------------------------------------------FLKQA----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------WFIENEEQEY---IKTVKGYKGGPGSAVSPY PTFNPSSDVEALHKAITVRGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKA LVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNGEIREINRVYREE LKRDLAKDIASDTSGDYEKALLSLAKGDRSE-ELA-VNDDLADSDARALYEAGERRKGTD VNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMF FAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEK ILVALCGGN-- >tr|A8E5G1|A8E5G1_DANRE Annexin OS=Danio rerio OX=7955 GN=anxa2b PE=1 SV=1 M----------------------------------------------------ALVSE-- --------------------------------------------------YLSKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------TLSY-------GGEREPKCPTVVAA YDFNPEVDAAKIETAIKTKGVDEQTIIDILTRRSYLQRNDIAFEYEKRAKKDLVSALKGA LSGSLEHLILGLMKSTPQYDAFELKASMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEM FKKDLEKDISGDTSGDFAKLLLALAQGKREE-QSSVVDYEKIDNDARTLYETGVKRKGTD VVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTLVECLENKHLY FASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQR ALLNLVGGDD- >XP_025055252.1 annexin A2 [Alligator sinensis] M----------------------------------------------------STVHE-- --------------------------------------------------ILTKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSIPPSAYATVKAY SNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELSAALKSA LSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQELAEINRVYKEM YKIELEKDIVSDTSGDFRKLMVALAKGRRSE-DSSMVDYELIDQDARDLYDAGVKRKGTD VPKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKG---- ----------- >XP_006259442.1 PREDICTED: annexin A2 [Alligator mississippiensis] M----------------------------------------------------STVHE-- --------------------------------------------------ILTKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSLPPSAYATVKAY SNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELSAALKSA LSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQELAEINRVYKEM YKIELEKDIVSDTSGDFRKLMVALAKGRRSE-DSSMVDYELIDQDARDLYDAGVKRKGTD VPKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKGDYQK ALLNLCGGED- >XP_020749772.1 annexin A2 [Odocoileus virginianus texanus] M----------------------------------------------------STVHE-- --------------------------------------------------ILCKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------SLEG------DHSTPPSAYGSVKAY TNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSA LSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEM YKTDLEKDIVSDTSGDFRKLMVALAKGRRAE-DGSVIDYELIDQDARDLYDAGVKRKGTD VPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQK ALLYLCGGDD- >XP_040198909.1 annexin A2 [Rana temporaria] M----------------------------------------------------ATIHE-- --------------------------------------------------ILGKL----- ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ -----------------------------------KLEG-----NQSSTTQHALGTVRPS TNFDAEKDAAALETAIKTKGVDELTIISILTNRTNDQRQDIAFAYQRRTKKDLPSALKGA LSGHLETLILGLMKTRPQYDASELKSAMKGLGTDEDTLIEIICSRDNDELHAIQAAYKEL YKTELEKDIVSDTSGDFRKLMVALAKGKRQE-DGSVVDYEKIDQDARELYEAGVKRKGTD VSKWITIMTERSICHLQKVFDRYKSYSPYDMQESIKKEVKGDLENAFLNLVQCIQNKPLY FADRLYESMKGKGTKDKILIRNMVSRCEVDLLKIKAEFKRKYNKSLSYFISQDTKGDYQR ALLNLCAGDD-
BMGE Cleaned alignment of selected proteins >NP_004030.1 annexin A2 isoform 2 [Homo sapiens] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >KAF4020192.1 hypothetical protein G4228_012105 [Cervus hanglu yarkandensis] AMVSEFLKQAGSAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNREIREINRVYREELKRDLAKDIASDTSGDYEKALLSLAKGDRSEELA-VNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGGN- >XP_030835585.1 annexin-B12 isoform X2 [Strongylocentrotus purpuratus] SY---YPPQATGTVKPKANFNGQKEAEILRKAMKGMGCDETAVISIMTTCSAVQRRQIALDFKTMYGKDLEKNLKGELKGKLETIVLNLLYLPAEFDAHMLRKAMKGLGTDEATLVEVLCTRTNDEVQAIKVAYKKEFSRDLEKDVISETSGHFKRLLVSMLQGSRSQDQR-VDVEKAKADAKALVTAGEARWGTDESAFNAVLASRSYPQLRAIFNEYSKLVKYTMEQSIKREMSGDLEKGMLTIVQCVRNTPAYFAEKLYKSMKGLGTDDDTLMRVIISRVEIDMVEIKQEFQRAYNQSLGRFIKGDTSGDYKKILLALIGGE- >CAE1230049.1 ANXA7_11 [Sepia pharaonis] AYIAFYSAQPEGTLKPYPGFNAETDAQILRKAMKGFGTDEKAIIDVLGSRSNEQRQDIVRMFKTIFGKDLIKELKSELSGNFETVVLGLLYTPSMYDATELKKAMQGLGTNEDVLIEIMCSRSNKEIMEISDCFKKITGKSLENWLKSETSGHFCRLLVSLSTAGRSENQN-VDLQSAEQDAKKLYEAGEKQWGTNESQFNAILASRSLPQLKAVFDAYKHLYNRDIEQVIASEMSGDLLSGMLSVVKVVKSKPCYFAERLYTSMKGAGTNDSTLIRVIISRCEIDMKQIKQEFQKMYGKTLDAMVKGDCSGDYCRILLRLLGNES >XP_038060971.1 annexin A5-like [Patiria miniata] SYGGYYPPAATGTVKEKSNFDGHKEAEILRKAMKGIGTDEKAIIGVVTACSNAQRQRLLIDYKTMYGKDLVKNLKSELKSKLEEVVLDLMMTPALFDAHQLRKAMKGLGTDEAVLIEILCTRTNQEIVTIKEAYKKEFSRNLEKDVISETSGHFQRLLVSMTQGARREDPT-VDQAKAKADAKALWDAGEKKWGTDESQFNVILASRSFPQLRATFEEYSKLGKYSIEQSIKREMSGDLEKGMLTIVDCVRNTPKYFSDKLYKSMKGLGTDDDTLIRIIVSRCEIDMVEIKQEFHRDHKQTLGKFIAGDTSGDYKKILLELVGGES >XP_031556011.1 annexin-B12-like isoform X2 [Actinia tenebrosa] SY----MPQPRPSVTAYSPFDGKKDAEVLRKAMKGLGCDNKAITYLLCSRTNAQRQRISIEYKTIYGRDLMKDLKSELGGHFEDTVIALMTPPEEYDATLIRKALKGLGTNEEILIEILSTRTNNELVAIKNAYQRLFERDMEKDIAGDTSGHFKKFLISLAQAYREETDQ-VDIHKARASAEALYKAGEGRWGTDEAKFNSVLASKSFPQLRAVFDEYSKICKYDIEESIRREMSGDLKDGMVSIVQVVRNAPGFFAQKLYKSMKGLGTDDKALIRVVVTRSEIDILDIKDEFAKQYGQSLAQFIADDTKGNYKRILLQLIGESA >XP_039270557.1 annexin A4-like isoform X2 [Styela clava] SY---YPPQPHGTVKAYPSFNAEEDAKILRKAMKGIGTDEKSIINVIGHRNNKQRQDIIIAYKQAYGKDLIKDLKSELSGNFESLVKAMFMKPRHYDVYCLERSMSGIGTDESALIEIFTSRSNAEIKEIKEIFKKERKKDLEKALKSETSGHFSRLLVSLCNASRNETTS-VDQGKARADAQALYQAGEKKWGTDEATFNMIMCSRSIPQLRATFIEYHKIANRDISKSIEGEFSGDIEEGLKAVVETARSAPAYFAKRLYKSMSGAGTDDHTLIRIVVSRSEIDMVEIKQEFQRTYSKTLGSFIQGDTSGDYKNLLTTLVGP-- >XP_026296548.1 annexin B9 [Apis mellifera] ----------TPTVYPAEPFDANADAALLRKAMKGFGTDEKTIIDVLTRRGIVQRLEVAEAYKTLYGKDLISDLKSELTGKLEDVIIALMTPLPHYYAKELHDAVSGLGTDEEAIVEILCTLSNYGIRTIAAFYENLYGKSLESDLKGDTSGHFKRLLVSLVQANRDENQG-IDQTQAIADAQALYEAGEKQWGTDESQFNAILVTRSYQQLRQTFIEYEKISGHDIEVAIKKEFSGNLEKGLLGIVKCVKSKVGFFAERLYASMHGIGTKDRTLIRIIVSRSEIDLGDIKKAFEERYGKSLESWIAGDTSGDYKKALLSLVST-- >NP_476615.1 annexin B10, isoform A [Drosophila melanogaster] EY--------VPTVKDAAPFDASQDAQVLRAAMKGFGTDEQEIIDVLVGRSNQQRQTIKAVYEAEFERDLVDDLKDELGGKFEDVIVGLMMPPVEYLCKQLHAAMAGIGTEEATLVEILCTKTNEEMAQIVAVYEERYQRPLAEQMCSETSGFFRRLLTLIVTGVRDGDTP-VDVGQAKEQAAQLYSAGEAKLGTDEEVFNRIMSHASFPQLRLVFEEYKVLSGQTIEQAIKHEMSDELHEAMMAIVECVQSPAAFFANRLYKAMNGAGTDDATLIRIIVSRSEIDLETIKQEFERIYNRTLHSAVVAETSGDYKRALTALLGSA- >NP_001022756.1 Annexin [Caenorhabditis elegans] NS---YPNQQTPSVFPVQGFNSNADAEVLRKAMKGLGCNNSKVISILCQRTNWQRQEISKAFKVMYGKDLIKELKGELHGDFEDLILALMDAPAIYDAKQLHRAMEGLGTKESVLIEIMTSRTNAQIQQVRDAYKMLFKKDLERDLIGETSGHFKRLLVSLCAGGRDESSQ-TDGLRANQDARRLLQAGEKRLGTDESTFNAILASQNFSQLRLVFEEYQKASNHSIEKAIEFEFSGDIRDGLLAVIAVIRNRPAYFAKLLHDSMKGLGTRDNDLIRLCVTRAEYDMGDIRNMFQSLYRTSLENMIKGDCSGAYKEGLIALVNGNR >NP_031611.1 annexin A2 [Mus musculus] STVHEILCKLYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_063970.1 annexin A2 [Rattus norvegicus] STVHEILCKLYGSVKPYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPSAMKSALSGHLETVMLGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGEFRKLLVALAKGKRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYFIQQDTKGDYQKALLYLCGGDD >NP_777141.1 annexin A2 [Bos taurus] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_990682.1 annexin A2 [Gallus gallus] STVHEILSKLYATVKAYSNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEINRVYREMYKTELEKDIISDTSGDFRKLMVALAKGKRCEDTSVIDYELIDQDARELYDAGVKRKGTDVPKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKGKGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQRALLNLCGGED >NP_001002961.1 annexin A2 [Canis lupus familiaris] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001005726.1 annexin A2 [Sus scrofa] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIXIMVSRSEVDMLKIRSEFKRKYGKSLYNYIQQDTKGDYQKALLYLCGGDD >XP_001155637.2 annexin A2 [Pan troglodytes] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001087257.1 annexin A2 [Ovis aries] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001126816.1 annexin A2 [Pongo abelii] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_017203467.1 PREDICTED: annexin A2 [Oryctolagus cuniculus] STVHEILCKLYGSVKAYGNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELPAALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYSYIQQDTKGDYQKALLYLCGGDD >XP_031411076.1 annexin A2 [Meleagris gallopavo] STDTEVLGSIYATVKAYSNFDADRDAAALEAAIKTKGVDEVTIINILTNRSNEQRQDIAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPSQYDASELKAAMKGLGTDEDTLIEIICSRTNQELNEINRVYREMYKTELEKDIISDTSGDFRKLMVALAKGKRCEDTSVIDYELIDQDARELYDAGVKRKGTDVPKWINIMTERSVPHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFINLVQCIQNKQLYFADRLYDSMKGKGTRDKVLIRIMVSRCEVDMLKIKSEFKRKYGKSLYYFIQQDTKGDYQRALLNLCGGED >XP_003827964.1 annexin A2 [Pan paniscus] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_003987117.1 annexin A2 [Felis catus] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELTSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFDRYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYCIQQDTKGDYQKALLYLCGGDD >XP_004056331.1 annexin A2 [Gorilla gorilla gorilla] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNAQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_017909777.1 PREDICTED: annexin A2 [Capra hircus] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >KAB0341462.1 hypothetical protein FD754_018388 [Muntiacus muntjak] SCMAESLC----------------------------CVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >NP_001081284.1 annexin A2-A [Xenopus laevis] ALIHEILGKLLGTVKASTNFDAEKDAAAIETAIKTKGVDELTIINILTNRSNDQRQDIAFAYHRRTKKDLASALKGALSGNLETVMLGLIKTRPQYDASELKASMKGLGTDEDTLIEIICSRTNKELLDIQNAYRELYKTELEKDIVSDTSGDFRKLMVALAKGKRQEEGSVVDYEKIDQDARELYEAGVKRKGTDVGKWITIMTERSTPHLQKVFERYKSYSPYDMEESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYESMKGRGTKDKILIRTMVSRSELDMLKIRKEFKKKYGKSLHYFIGQDTKGDYQRALFNLCGGDD >OWK09220.1 ANXA2 [Cervus elaphus hippelaphus] --------------------------------------------------------------------------------------------------------MKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_015808682.1 PREDICTED: annexin A2-B-like [Nothobranchius furzeri] ALVSEFLGQLYPTVVPVRDFDPVRDAARIDTAIKTKGVDEQTVIDILTRRSAQQRQEIAFEFERFSKKDLTSALKGALSGSLETLVLGLMKTTTQYDASELKASMKGLGTDEETLIELVCSRNDDELTEIKKVYREMFKKELDKDIAGDTSGDFAKLLLALVQTKRDEPSNVVDYQKIDDDARSLYEAGVKRKGTDVVTWISIMSQRSIPHLRKVFERYKSYSPYDMKESIRKEVKGDLEKSFLTLVECFENKQLYFANRLYEAMKSKGAKEKVVTRIMVSRCEVDLMRIRTEFKRQYKKSLYQTIAEHTKGDYQKALLSLCGGDD >XP_030271470.1 annexin A2-like [Sparus aurata] ALVSEFLGQLFPTVVPVHDFDPNKDAARIETAIKTKGVDEQTIIDILTRRSYEQRRQIAFEYERLAKKDLVTALKAALSGSLEALMLGLMKSTAQYDASELKASIKGLGTDEEALIEIVCSRNNEELVEIKRVYKEMFKKELEKDIAGDTSGDFAKLLLALFQTKRDEPSNVVDYEKIDEDARCLYEAGVKRKGTDVGTWISIMAKRSVPHLQKVFERYKSYSPYDMKESIRKEVKGDLEKSFLTLVECFENRQLYFANRLSEAMKSKGAKEKVVTRIIVSRCEVDLMKIRTEFKRQHKRSLYQTIAEHTKGDYQKALLSLCGGDD >XP_023809545.1 annexin A2 [Oryzias latipes] AMVSEFLGQLCPTVVPVKDFDPTHDAARIDAAIKTKGVDEQTIIDILTRRSCQQRREIAFEYERMAKKDLSSALKGALSGSLEALMLGLMKSTAQFDASELRASMKGLGTDEEVLIEMLCSRSEEELMEIKKEYREMFKKEVEKDIAGDTSGNFAKLLLALVQTRRDEPSNVVDYQKIDEDARSLYEAGVKRKGTDVTTWISIMSQRSVPHLQKVFERYKSYSPYDIKESIKKEVKGDLEKSFLTLVECFENRQLYFANRLNDAMKSKGAKEKVLTRIMVSRCEVDLMKIRTEFKKHHRRSLYQTIAEHTKGDYQKALLSLCGGDD >KAB0368712.1 hypothetical protein FD755_019746 [Muntiacus reevesi] AMVSEFLKQAGSAVSPYPTFNPSSDVEALHKAITVKGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNKEIREINRVYREELKRDLAKDIASDTSGDYEKALLSLAKGDRSEELA-VNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNQPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGGN- >XP_043343301.1 annexin A1 [Cervus canadensis] AMVSEFLKQAGSAVSPYPTFNPSSDVEALHKAITVRGVDEATIIEILTKRNNAQRQQIKAAYLQEKGKPLDEVLKKALVGHLEEVVLALLKTPAQFDAEELRAAMKGLGTDEDTLNEILASRTNGEIREINRVYREELKRDLAKDIASDTSGDYEKALLSLAKGDRSEELA-VNDDLADSDARALYEAGERRKGTDVNVFTTILTTRSYPHLRRVFQKYSKYSKHDMNKVLDLELKGDIEKCLTVIVKCATNKPMFFAEKLHQAMKGIGTRHKTLIRIMVSRSEIDMNDIKACYQKLYGISLCQAILDETKGDYEKILVALCGGN- >tr|A8E5G1|A8E5G1_DANRE Annexin OS=Danio rerio OX=7955 GN=anxa2b PE=1 SV=1 ALVSEYLSKLCPTVVAAYDFNPEVDAAKIETAIKTKGVDEQTIIDILTRRSYLQRNDIAFEYEKRAKKDLVSALKGALSGSLEHLILGLMKSTPQYDAFELKASMKGLGTDEESLIEMVCSRNKEELAEIKKVYKEMFKKDLEKDISGDTSGDFAKLLLALAQGKREEQSSVVDYEKIDNDARTLYETGVKRKGTDVVTWISIFSERSVSHLQKVFERYKRYSPYDIKESIRMEVKGDLEKSFLTLVECLENKHLYFASRLNDAMKGKSVKDKIITRIIVSRCEVDLMKVRIEFKRNFGRSLHQTISEHTKGDYQRALLNLVGGDD >XP_025055252.1 annexin A2 [Alligator sinensis] STVHEILTKLYATVKAYSNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQELAEINRVYKEMYKIELEKDIVSDTSGDFRKLMVALAKGRRSEDSSMVDYELIDQDARDLYDAGVKRKGTDVPKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKG-------------- >XP_006259442.1 PREDICTED: annexin A2 [Alligator mississippiensis] STVHEILTKLYATVKAYSNFDADRDAAALETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELSAALKSALSGHLEAVILGLLKTPAQYDASELKGAMKGLGTDEDTLIEIICSRTNQELAEINRVYKEMYKIELEKDIVSDTSGDFRKLMVALAKGRRSEDSSMVDYELIDQDARDLYDAGVKRKGTDVPKWINIMTERSIPHLQKVFERYKSYSPYDMLESIRKEVKGDLENAFLNLVQCIQNKQLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKVKSEFKRKYGKSLYYFIQQDTKGDYQKALLNLCGGED >XP_020749772.1 annexin A2 [Odocoileus virginianus texanus] STVHEILCKLYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNILTNRSNEQRQDIAFAYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIVSDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARDLYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKKKYGKSLYYYIQQDTKGDYQKALLYLCGGDD >XP_040198909.1 annexin A2 [Rana temporaria] ATIHEILGKLLGTVRPSTNFDAEKDAAALETAIKTKGVDELTIISILTNRTNDQRQDIAFAYQRRTKKDLPSALKGALSGHLETLILGLMKTRPQYDASELKSAMKGLGTDEDTLIEIICSRDNDELHAIQAAYKELYKTELEKDIVSDTSGDFRKLMVALAKGKRQEDGSVVDYEKIDQDARELYEAGVKRKGTDVSKWITIMTERSICHLQKVFDRYKSYSPYDMQESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYESMKGKGTKDKILIRNMVSRCEVDLLKIKAEFKRKYNKSLSYFISQDTKGDYQRALLNLCAGDD
PhyML tree of selected proteins (((XP_031411076_1_annexin_A2__Meleagris_gallopavo_:0.022751,NP_990682_1_annexin_A2__Gallus_gallus_:0.00000001):0.03157773,((((XP_017909777_1_PREDICTED__annexin_A2__Capra_hircus_:0.00000001,(NP_001087257_1_annexin_A2__Ovis_aries_:0.00000001,(NP_777141_1_annexin_A2__Bos_taurus_:0.00000001,XP_020749772_1_annexin_A2__Odocoileus_virginianus_texanus_:0.00000001):0.00000001):0.00000001):0.00000001,(OWK09220_1_ANXA2__Cervus_elaphus_hippelaphus_:0.00000001,KAB0341462_1_hypothetical_protein_FD754_018388__Muntiacus_muntjak_:0.00000001):0.01839863):0.00411829,((XP_003987117_1_annexin_A2__Felis_catus_:0.00638402,((XP_003827964_1_annexin_A2__Pan_paniscus_:0.00000001,(NP_001126816_1_annexin_A2__Pongo_abelii_:0.00000001,(XP_001155637_2_annexin_A2__Pan_troglodytes_:0.00000001,(NP_004030_1_annexin_A2_isoform_2__Homo_sapiens_:0.00000001,XP_004056331_1_annexin_A2__Gorilla_gorilla_gorilla_:0.00000001):0.00000001):0.00000001):0.00000001):0.00650011,(XP_017203467_1_PREDICTED__annexin_A2__Oryctolagus_cuniculus_:0.01324697,(NP_031611_1_annexin_A2__Mus_musculus_:0.0064122,NP_063970_1_annexin_A2__Rattus_norvegicus_:0.02256951):0.00955183):0.00318415):0.00318256):0.00312628,(NP_001005726_1_annexin_A2__Sus_scrofa_:0.00316264,NP_001002961_1_annexin_A2__Canis_lupus_familiaris_:0):0):0.00220023):0.04472951,((((KAF4020192_1_hypothetical_protein_G4228_012105__Cervus_hanglu_yarkandensis_:0,(KAB0368712_1_hypothetical_protein_FD755_019746__Muntiacus_reevesi_:0.00633239,XP_043343301_1_annexin_A1__Cervus_canadensis_:0.00636098):0):0.55878217,(((NP_476615_1_annexin_B10__isoform_A__Drosophila_melanogaster_:0.71018806,XP_026296548_1_annexin_B9__Apis_mellifera_:0.4551606):0.14850878,(XP_039270557_1_annexin_A4_like_isoform_X2__Styela_clava_:0.40722269,CAE1230049_1_ANXA7_11__Sepia_pharaonis_:0.39781116):0.09954351):0.08086975,((NP_001022756_1_Annexin__Caenorhabditis_elegans_:0.71315445,XP_031556011_1_annexin_B12_like_isoform_X2__Actinia_tenebrosa_:0.42275338):0.1114434,(XP_038060971_1_annexin_A5_like__Patiria_miniata_:0.15650145,XP_030835585_1_annexin_B12_isoform_X2__Strongylocentrotus_purpuratus_:0.2063947):0.16331101):0.02838452):0.44171803):0.32779314,(tr_A8E5G1_A8E5G1_DANRE_Annexin_OS_Danio_rerio_OX_7955_GN_anxa2b_PE_1_SV_1:0.1482838,(XP_030271470_1_annexin_A2_like__Sparus_aurata_:0.06230253,(XP_023809545_1_annexin_A2__Oryzias_latipes_:0.08575722,XP_015808682_1_PREDICTED__annexin_A2_B_like__Nothobranchius_furzeri_:0.08047286):0.02928125):0.08390876):0.24224131):0.07686274,(XP_040198909_1_annexin_A2__Rana_temporaria_:0.07813703,NP_001081284_1_annexin_A2_A__Xenopus_laevis_:0.07484987):0.05371955):0.07583413):0.04322172):0.03573798,XP_006259442_1_PREDICTED__annexin_A2__Alligator_mississippiensis_:0.00000001,XP_025055252_1_annexin_A2__Alligator_sinensis_:0.00000001);
BLAST to find more sequences

Created by Puigbo and Nakamura @ University of Turku (2022)